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Daniel Perez, Hinge Health CEO: A Fortt Knox Update
Hinge Health CEO Dan Perez told Jon Fortt the company is launching a Migraine Care Program today, built around its FDA-cleared Enso wearable, now indicated for migraine via trigeminal-nerve neuromodulation. In trials, 56% of users dropped from moderate/severe pain to mild or no pain. The pitch: 1 in 6 adults, $78B in employer cost, only ~700 US specialists. 125 enterprise customers signed; ~2M American adults get day-one access. Earnings Tuesday.
Neuroinfectious Diseases Research Workshop: Advancing Translational Science and Clinical Innovation
The Neuroinfectious Diseases Research Workshop will be a two-day scientific meeting designed to accelerate research, foster collaboration, and build capacity in the field of neurological infections. Hosted at the NIH Neuroscience Center (NSC, Executive Boulevard), this meeting will bring together clinician-scientists, laboratory investigators, translational researchers, government partners, and trainees committed to advancing understanding of neuroinfectious
MIT scientists turn chaotic laser light into powerful brain imaging tool
Scientists at MIT discovered that chaotic laser light can spontaneously form a highly focused beam instead of scattering—if the conditions are just right. This “pencil beam” enabled them to image the blood-brain barrier in 3D at speeds 25 times faster than existing techniques. The method also lets researchers watch how drugs move into brain cells in real time. It could dramatically accelerate the development of treatments for neurological diseases.
Mayim Bialik brings message of mental health, resilience to Sacramento Speakers Series
The Sacramento Speakers Series is wrapping up its season with actor, neuroscientist and mental health advocate Mayim Bialik.
Zap in a cap: How one neurotech startup is using a hat to treat depression
FDA approved a request from Motif Neurotech, to start an initial feasibility trial to test a brain implant to treat depression.
Harvard scientists link gut bacteria to depression through hidden inflammation trigger
A gut bacterium may be quietly fueling depression through an unexpected chemical twist. Researchers found that when Morganella morganii interacts with a common pollutant, it produces a molecule that triggers inflammation—something strongly linked to depression. This finding helps explain how gut microbes can influence brain health at a molecular level. It also raises the possibility of new treatments that target the immune system rather than just the brain.
Science news this week: Atlantic current edges closer to collapse, scientists make artificial-neuron breakthrough, and a copy of the "Iliad" is found inside an Egyptian mummy
April 25, 2026: Our weekly roundup of the latest science in the news, as well as a few fascinating articles to keep you entertained over the weekend
A New Type of Neuroplasticity Rewires the Brain After a Single Experience
“Neurons that fire together, wire together” is not the full story. A novel mechanism explains how the brain can learn across longer timescales.
FSU neuroscientist earns national award for research on taste and eating behavior
A Florida State University neuroscientist has earned a national award for research on gustation, the scientific term for the sense of taste, and how it
Scientists invent artificial neurons that 'talk' to real brain cells, paving way to better brain implants
Engineers have found a way to fine-tune tiny artificial neurons to fire like real brain cells.
For the first time, scientists pinpoint the brain cells behind depression
Scientists have identified two specific types of brain cells that behave differently in people with depression, offering a clearer picture of what is happening inside the brain. By analyzing donated brain tissue with advanced genetic tools, the researchers found changes in neurons linked to mood and stress, as well as in immune-related microglia cells. These differences point to disruptions in key brain systems and reinforce that depression is rooted in biology, not just emotions.
This new brain-like chip could slash AI energy use by 70%
A breakthrough in brain-inspired computing could make today’s energy-hungry AI systems far more efficient. Researchers have engineered a new nanoelectronic device using a modified form of hafnium oxide that mimics how neurons process and store information at the same time. Unlike conventional chips that waste energy moving data back and forth, this device operates with ultra-low power—potentially slashing energy use by up to 70%.
WATCH: Pennsylvanians Impacted by Neurodegenerative Diseases
WATCH: Pennsylvanians Impacted by Neurodegenerative Diseases
On the frontlines of speech science with Liberty Hamilton and Alex
Last summer, UC Berkeley hired not one but two computational neuroscientists, Liberty Hamilton and Alex Huth, who study how the brain processes language. The pair has a lot more in common. Both
Got wearable data? Your doctor can help you connect the dots
The American Academy of Neurology issued guidance on using wearable data devices, like smart watches or Oura rings, to track key health metrics that can help flag serious conditions.
NYU Langone Health neurologists present latest clinical findings and research at AAN 2026
This year’s meeting features more than 80 presentations from Department of Neurology faculty. Here are notable highlights: practical strategies to counter harmful medical myths and misinformation, phase 3 clinical results for a novel epilepsy medication, and the barriers patients with disabilities face while navigating outpatient facilities.
IMG Academy, Neuro Challenge Foundation host Parkinson’s wellness event focused on movement and brain health
A unique event at IMG Academy is helping people with Parkinson’s disease stay active while raising awareness about the importance of movement and community support.
Paul Gosar's rally appearance reignites health speculation
Arizona Congressman Paul Gosar's appearance at a Turning Point USA rally has renewed public speculation about his health, with observers citing slurred speech, unsteady posture, and difficulty completing sentences. Social media users suggested, without evidence, possible neurological conditions, echoing similar concerns raised in past years. Gosar has consistently denied such rumours, attributing symptoms to arthritis, spinal issues, and past surgeries.
In memoriam: Pavithra Sundaresh, senior, College of Science
Sundaresh, a senior in the School of Neuroscience, passed away on March 30. She was 20 years old.
Two scientists to receive 2026 Ralph L. Sacco Scholarships for Brain Health
DALLAS and MINNEAPOLIS, April 17, 2026 — The American Academy of Neurology and the American Heart Association have awarded the 2026 Ralph L. Sacco Scholarships for Brain Health to two neuroscientists, Sarah Kettlety, Ph.D., of Baltimore, Maryland, and...
The subtle science behind safer brain implants
In a recent publication appearing in Advanced Science, researchers at the Netherlands Institute for Neuroscience challenge the assumptions surrounding the design and materials used for brain implants. ...
The surprising reason you’re so productive one day and not the next
Feeling mentally “on” isn’t just in your head—it can significantly boost what you accomplish. Researchers found that sharper thinking on a given day leads people to set bigger goals and actually follow through. That edge can equal up to 40 extra minutes of productivity. But push too hard for too long, and the effect reverses.
A new approach to brain health, one neuron at a time
Neuroscientist Paul Nuyujukian likens the brain to a stadium full of people. To eavesdrop on the crowd you could put a microphone in the middle of the stadium. But to understand the conversations you need to record individual people. He thinks about the brain the same way. To understand brain disease, he studies neurons—one at a time. And his insights are shedding light on a big global issue—stroke. The World Health Organization predicts one in four adults will have a stroke in their lifetime. Strokes can cause death, or lead to paralysis or speech problems. But there’s still a lot researchers don’t know about how the brain recovers from an event like a stroke. Nuyujukian directs a lab at Stanford University that studies how the brain controls movement, including after neurological events like stroke. We get into how he does this, and why he hopes his research could eventually help people who’ve been paralyzed. Email us your questions about the brain – or anything else to do with science at shortwave@npr.org. We may turn it into an episode in the future!Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.
Indian American Neurologist Pria Anand wins literary science writing award
Boston-based physician earns PEN/E.O. Wilson prize for exploring the brain, the mind, and the soul.
STAR Seminar- Reimagining Youth Sport as a Brain-Based Environment for Mental Health
Youth mental health challenges are rising globally, yet one of the most accessible youth-serving systems — sport— remains underutilized as a public health strategy. This Stress, Trauma, and Resilience (STAR) Seminar explores how insights from developmental neuroscience, trauma research, and sport-based youth development can transform everyday sport experiences into environments that promote regulation, connection, and resilience.
Eye on the Y: BYU neuroscience student advances science of seizure intervention, Elder Ulisses Soares to speak at April 2026 commencement and Grantwell program gives students opportunities to work with nonprofit organizations
Melissa Blotter: Advancing the science of seizure intervention
Scientists Grow Electronics Inside the Brains of Living Mice
The technology harnesses the brain's own blood chemistry to assemble soft, light-controlled electrodes around neurons.
Scholarships support rising stars of science
Two UVA students – a neuroscience major and a materials engineering major – received Goldwater Scholarships.
Sam Wang, Politician-in-Training
The neuroscientist went from analyzing elections to running for Congress. But can this rookie win over New Jersey locals—and Trump voters?
Universities Allied for Essential Medicines advocates for affordable health care
While a vial of insulin takes as little as $2 to manufacture, it can cost consumers $250 in the United States. Universities Allied for Essential Medicines, an international advocacy organization that has chapters at universities including UCLA, raised awareness about medication unaffordability during its annual North American conference at the Neuroscience Research Building from April 3 to 5.
Manipulating Science, Manipulating Us
Four decades ago, I and Gerald Markowitz published an article in the American Journal of Public Health that attracted a fair amount of attention. The article was about the history of the introduction of tetraethyl lead into gasoline in the 1920s. The article detailed the controversy over putting lead, even then a known industrial poison and neurotoxin, into the gasoline that was powering the new automobile, particularly those that were produced by the General Motors Company.
Neuroscientist To Lead Engineering-Driven Brain Health Research
Dr. Matthew Walker joined UT Dallas in January to build the future of sleep science. His research spans fundamental neuroscience and the development of innovative engineering tools to improve the quality of life. Dr. Matthew Walker is helping to transform sleep research from an observational field into one in which engineered solutions can measure and […]
Neuroscientist To Lead Engineering-Driven Brain Health Research
Dr. Matthew Walker joined UT Dallas in January to build the future of sleep science. His research spans fundamental neuroscience and the development of innovative engineering tools to improve the quality of life. Dr. Matthew Walker is helping to transform sleep research from an observational field into one in which engineered solutions can measure and […]
3L Rachel Sadler Charts Path in Brain Health, Technology, and Policy Through UC Law SF’s Health Law Concentration - UC Law San Francisco (Formerly UC Hastings)
3L Rachel Sadler studies health law and policy at UC Law SF while researching the legal implications of neurotechnology and other emerging tools that may affect human cognition. 3L student Rachel Sadler shares how UC Law SF’s Health Law Concentration prepared her for a career focused on the intersection of brain health, government policy, and technology. Gained a detailed understanding of how U.S. health care is regulated and where policy reform is needed through coursework and research. Interned with state and federal agencies that regulate health care services and worked with a major health care provider’s bioethics department. Plans to pursue a career focused on protecting cognitive liberty and mental privacy as new technologies reshape healthcare. 3L Rachel Sadler: The Health Law Concentration has given me fluency in one of the most complex regulated industries and the tools to become an effective advocate for better health policy. Before coming to law school, I spent a decade teaching and working with teachers and administrators on high school programming for multilingual learners. Healthcare kept emerging as the most powerful driver of student outcomes. I wanted to understand how to make effective policy change in this area and how to use existing law to defend people’s health rights in California. Through the concentration’s coursework, I gained a sophisticated understanding of how U.S. healthcare is regulated. I also learned where the pressure points for reform exist. The courses gave me space to develop what became my central research interest: how law and policy can be built to protect human cognition and healthy brain development, particularly regarding new technologies such as generative AI and neurotechnology. The health law faculty were instrumental in that process, genuinely invested in helping me and other students define and pursue our own intellectual vision. During law school, I interned at the General Counsel’s Office for Region IX of the U.S. Department of Health and Human Services. I also externed at the California Department of Justice’s Health, Education and Welfare Division. Additionally, I externed at Kaiser Permanente Northern California’s Bioethics Department. Alongside those placements, I conducted extensive independent research on mental privacy and emerging neurotechnology, working closely with Professors Emily Murphy and George Horvath. That research became the throughline of my law school experience and the foundation of my current policy focus. I must also credit Nicole Ozer of the Center for Constitutional Democracy (CCD), whose deep knowledge of California privacy law and the public-interest privacy landscape deeply informed my work. I currently serve a research assistant with the CCD, where I spearhead the development of K-12 educational resources in partnership with law faculty and students. I’ve found UC Law SF to be an ideal place for second-career, nontraditional students. There is a tremendous diversity of life and career experience here, and I felt fully welcomed into the community, despite returning as a student at a different stage of life. I came to law school wanting to promote equity in California’s healthcare system. I am leaving with a sharper and more specific ambition: to build a policy career focused on protecting cognitive liberty and mental privacy from technological intrusion. This is both an urgent and underserved area of law, and I want to be part of defining this landscape going forward. Whether as a practicing attorney or a policy advisor, I plan to work on these issues after law school. I strongly recommend UC Law SF and the Health Law Concentration. When I arrived in law school, I worried the concentration would be narrow and that my non-clinical background would be a disadvantage. The opposite was true. The health law faculty thinks about health expansively, encompassing social determinants of health, structural inequity, and emerging technologies alongside the regulatory mechanics of the industry. The faculty are accessible, intellectually generous, and genuinely invested in students’ development. I found my research vision here, and I deeply appreciate the concentration’s role in this. The Evidence of Success series highlights UC Law SF students as they share how the College’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.
Michael Patrick of 'Game of Thrones' Dies at 35. Motor Neuron Disease, Explained
The actor passed away on April 7 following a three-year-long health battle.
Scientists Have Found a New Neurodevelopmental Disorder Hidden in Our Genes
And it may be relatively prevalent.
Immunic COO highlights the importance of science-led innovation to mark World Health Day
Immunic Inc (NASDAQ:IMUX, FRA:10VA) chief operating officer Jason Tardio talked with Proactive's Stephen Gunnion about the importance of science-led innovation in tackling neurological diseases, particularly multiple sclerosis, on World Health Day 2026. Tardio highlighted that the biotech industry is fundamentally grounded in scientific research and data, noting that “everything we do is rooted in science.” He explained that Immunic is focused on developing innovative therapies designed to improve patient outcomes and address significant unmet medical needs. The discussion centred on multiple sclerosis (MS), a complex neurological disease that continues to present challenges despite decades of progress. Tardio pointed out that while advancements have been made, “the disease is not solved for,” with many patients still experiencing disability progression and requiring safer, more tolerable treatments. He emphasised the urgent need for innovation, particularly in progressive forms of MS where treatment options remain extremely limited. Immunic’s lead asset, vidofludimus calcium, is being developed as a novel approach aimed at addressing the full spectrum of the disease. Tardio also reinforced the broader mission of the healthcare and biotech sectors, stating that the ultimate goal is to help individuals “live a better quality of life” and “a healthier life longer.” Watch the full interview to learn more about Immunic’s approach to advancing MS treatment through science. For more videos like this, visit Proactive's YouTube channel, like this video, subscribe to the channel, and enable notifications so you never miss an update. #Immunic #MultipleSclerosis #BiotechInnovation #Healthcare #MSResearch #DrugDevelopment #ClinicalTrials #Neurology #WorldHealthDay #ScienceDriven #VidofludimusCalcium #PharmaNews #BiotechNews
Scientists map the brain’s hidden wiring using RNA barcodes in major breakthrough
Researchers have developed a cutting-edge technique that uses RNA “barcodes” to map how neurons connect, capturing thousands of links with single-synapse precision. The method transforms brain mapping into a sequencing task, making it faster and more scalable than traditional approaches. In mice, it revealed surprising new connections between brain cells that were previously unknown. This could open the door to earlier detection and targeted treatment of neurological diseases.
4 NYU faculty honored for STEM research by American Association for the Advancement of Science
Four NYU faculty members were recognized for their research in areas of biology, neuroscience and chemical and biomolecular engineering as fellows of the American Association for the Advancement of Science. The AAAS — which aims to shape science policy and build a community for STEM researchers — elected 449 researchers across the United States for...
SK Life Science, Inc. to Present New Data and Epilepsy Insights at the 2026 American Academy of Neurology Annual Meeting
Key Facts: SK Life Science, Inc. will present multiple posters at the American Academy of Neurology (AAN) Annual Meeting (April 18–22, 2026, Chicago, Illinois)...
Scientists discover hidden brain switch that tells you to stop eating
Your brain’s “stop eating” signal may come from an unexpected source. Researchers found that astrocytes—once thought to just support neurons—actually play a key role in controlling appetite. After a meal, glucose triggers tanycytes, which send signals to astrocytes that then activate fullness neurons. This newly discovered pathway could lead to innovative treatments for obesity and eating disorders.
The brain might not create consciousness after all
Is consciousness something the brain produces, or is it woven into the fabric of reality itself? Renowned neuroscientist Christof Koch is challenging long-held scientific assumptions by confronting the “hard problem” of consciousness — why and how subjective experience exists at all. He highlights growing tensions between neuroscience, physics, and unexplained phenomena like near-death experiences and sudden moments of clarity before death.
These overlooked brain cells may control fear and PTSD
Astrocytes, once thought to be mere brain “support cells,” are now revealed to be key players in fear memory. Researchers found they actively help form, recall, and weaken fear responses by interacting with neurons in real time. Changing astrocyte activity directly altered how strong fear memories became. This breakthrough could lead to entirely new treatments for anxiety-related disorders.
A gene mutation may trap the brain in the wrong reality in schizophrenia patients
A newly identified gene mutation may help explain why schizophrenia patients struggle to update their understanding of reality. The mutation disrupts a brain circuit involved in flexible decision-making, causing mice to stick with outdated choices even when conditions change. Researchers pinpointed the issue to a key thalamus–prefrontal cortex pathway. By reactivating this circuit, they were able to restore normal behavior—raising hope for future therapies.
UNM to host national leader in sports medicine for community lecture on concussions
The University of New Mexico Department of Neurology will host a community lecture featuring Dr. Brian Hainline on Tuesday, April 15 from 6 to 8 p.m., at the Physics and Astronomy Interdisciplinary Science (PAIS) Auditorium on the Albuquerque...
Women get Alzheimer’s more often than men: Five things the science tells us
Women develop Alzheimer’s disease at higher rates than men. Stanford Medicine neurologists explain what science knows about why and the many things it doesn’t yet know.
NIH awards $15.8 million to UC Davis Health for major Hispanic-Latino brain health study
The NIH has awarded neurologist and dementia expert Charles DeCarli a $15.85 million grant to support one of the nation’s most extensive studies on brain aging in Hispanic-Latino communities.
Memorial fund honors patient whose life was saved by Vanderbilt Health neurosurgeons
Charlotte Davis underwent groundbreaking brain mapping surgery at Vanderbilt Health in 1995 to treat a deep-seated brain tumor. The procedure preserved areas controlling speech and movement. She lived 30 more years after her surgery.
Who Gets to Do Science?
Who Gets to Do Science?: A neuroscientist who spent the last decade tearing down the class, race, and language barriers that keep people like him out of research
Céline Dion Announces Comeback Concerts After Health Struggles
Music icon Céline Dion shared a surprise video message on her 58th birthday that she’s returning to the stage with ten concerts planned in Paris. Fans are celebrating her long-awaited comeback after she stepped away from performing back in 2022 when she was diagnosed with a rare neurological condition called “stiff person syndrome” which can cause muscle rigidity and painful spasms. NBC’s Emilie Ikeda reports for TODAY.
Celine Dion announces her return to the stage. She always believed she could
Celine Dion was previously sidelined from performing due to a rare neurological disorder called stiff person syndrome. Now, she’s back.
The science behind Easter candy cravings — and when it becomes too much
Americans love Easter candy, spending more than $5 billion on it in 2024, with chocolate bunnies and eggs among the most popular treats, according to the National Confectioners Association. While having a candy or two on a holiday isn’t a problem, consistently eating too much sugar can have significant negative effects. According to Brenda Davy, a professor in the Department of Human Nutrition, Foods, and Exercise at Virginia Tech and a registered dietitian, added sugar consumption is
Lee Health: Parkinson program – Support, movement and connection
Parkinson’s disease is a progressive neurological condition that affects many systems of the body, but it is referred to as a “movement disorder.”
Mom, 36, Had Health Symptoms Dismissed for Years. Then, She Was Diagnosed with One of the World’s Rarest Cancers (Exclusive)
A woman was diagnosed with one of the world’s rarest cancers, neuroendocrine cancer, after her health issues were dismissed over the years by multiple different types of doctors. Ashleigh Smith, a mom of two, worked a second job as a food delivery driver to help raise funds amid rising costs tied to her cancer treatments, she tells PEOPLE exclusively.
What to Know About Caffeine and Brain Health
A neurologist explains a recent study which found that moderate caffeine consumption reduces the risk of dementia.
Emotions in Motion: How Movement May Signal Mental Health Issues
Biomedical engineering senior Ian Y. Kim wears a motion capture suit during an experiment in the Neuromuscular and Musculoskeletal Biomechanics Lab at UT Dallas. New University of Texas at Dallas research shows the potential for detecting mental health disorders by analyzing the way a person moves. Using 3D motion capture and machine-learning models, researchers were […]
Two Salk scientists elected as 2025 AAAS Fellows - Salk Institute for Biological Studies
Highlights Salk scientists Gerald Shadel and Tatyana Sharpee elected as American Association for the Advancement of Science (AAAS) 2025 Fellows AAAS Fellows are distinguished scientists, engineers, and innovators who have made significant contributions to their fields LA JOLLA—Salk molecular biologist Gerald Shadel, PhD, and neuroscientist Tatyana Sharpee, PhD, have been elected as American Association for the Advancement of Science (AAAS) 2025 Fellows. The honor recognizes scientists with distinguished scientific and social accomplishments, and AAAS Fellows become national and global science spokespersons for the rest of their lives.
Eight L&S faculty members elected fellows of the American Association
Congratulations to the eleven UC Berkeley faculty members named AAAS Fellows. The newly elected Fellows include a tech pioneer, the author of a book on nature’s poisons and a neuroscientist who can
Eleven UC Berkeley faculty members elected fellows of the American Association for the Advancement of Science
The newly elected AAAS Fellows include a tech pioneer, the author of a book on nature’s poisons and a neuroscientist who can decode what you are seeing from your brain wave activity.
UCLA Health receives $2.4 million from Rose and Allen Nelson to establish a fellowship in translational and clinical neuroscience
The gift is being made in memory of their son Brandon, who received his bachelor’s in aerospace engineering from UCLA in 2014.
Scientists discover why this deadly lung cancer keeps coming back
Scientists have discovered that losing a key protein in small cell lung cancer triggers inflammation that actually helps tumors grow and spread. Even more surprising, it pushes cancer cells into a more aggressive, neuron-like state linked to relapse.
Addressing Concussion Risk and Recovery for Women in Sports
Heather P Adams, MPAS, PA-C, discusses why women in sports may face higher concussion risks and longer recovery times than men.
Q&A with Brain Health Expert Dr. James Galvin
The Miller School neurologist describes a new Brain Health Index that uses machine learning to measure brain health.
How the term ‘neurodivergent’ moved from activists to pop culture
Nick Minaj is one of the most recent Trump supporters to identify herself as “neurodivergent,” embracing a narrow definition of a once-niche term commonly associated with autism and ADHD.
Coeur d'Alene's science guy
Ahead of his retirement in May from the teaching staff at Arizona State University, behavioral neuroscientist Brian Smith has put his focus into making science more accessible to more people. “There's a lot of misunderstanding what science is,” Smith said.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Scientists discover surprising brain trigger behind high blood pressure
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Alto Neuroscience Reports Full Year 2025 Financial Results and Recent Business Highlights
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Minerva Neurosciences Reports Fourth Quarter and Fiscal Year 2025 Financial Results and Business Updates
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Mental health solutions for the digital age
Ask the digital natives of Gen Z about the source of their biggest mental health challenges, and most will say social media and AI.Several of the nearly 400 guests at the third annual Gen Z Wellness Summit, presented by the Friends of Semel Teen Advisory Council at UCLA on March 8, explicitly named the endless stream of content on their phones as serious stressors. “Everybody is addicted to (Tik Tok) as if they were addicted to substances,” said Jantin Asmar, 17, a senior at Virtual Academy in Antelope Valley. “We’re always chasing that dopamine. We’re expecting that dopamine rush and it’s really decaying our interactions with others.” High school student Jantin Asmar was among nearly 400 people who attended the third annual Gen Z Wellness Summit. (Photo by Sandy Cohen) Even young teens feel pressure to be on social media constantly, both to consume content and collect “likes,” said 13-year-olds Chloe and Sophia, both students at Brentwood School. “Everyone’s always on, and you miss stuff if you’re not on it,” Chloe said, adding that social media’s emphasis on appearances is leading to eating disorders: “That’s a big thing for our generation.”The incessant influx of images and updates creates expectations that “weigh teenagers down,” said Linda Kou, 16, a junior at San Gabriel High School.Even though digital spaces allow people to connect with others beyond their immediate surroundings, it doesn’t always translate to real-life community, said Kelah Morgan, 17, a senior at Animo South Los Angeles Charter High School. High school students Kelah Morgan, left, and Linda Kou, shared about the challenges presented by social media. (Photo by Sandy Cohen) “Even if you see people saying that they relate to you online, it might be hard to find people in your personal life who you see every day who you feel comfortable enough to say, ‘You see me online, but this is me in real life and what I’m actually going through,’” she said.Solutions for our digital timesThe Gen Z Wellness Summit was intentionally designed as a free, in-person gathering where young people interested in mental health from across the southland could meet in person. “Peer support is the most important element of maintaining our mental health in community,” said Helena Hansen, MD, PhD, director of UCLA’s Semel Institute for Neuroscience and Human Behavior.Keynote speakers at the summit addressed AI, social connection and self-empowerment, while breakout sessions included discussions about eating disorders, dating, substance use, phone detox and breathwork. Here are some of the day’s top takeaways:Beware of FOPO: Scott Barry Kaufman, PhD, a psychology professor at Columbia University, said that rather than FOMO, or fear of missing out, we ought to be more aware of FOPO: fear of people’s opinions. “Just think about how much your FOPO might be holding you back in your life,” Dr. Kaufman said. “And just that inner contemplation should be enough for you to change your life, because there’s so many things we don’t go after because we have debilitating FOPO.”We don’t need to feel like we’re the best – or what he called “narcissistic self-esteem” – but it’s helpful to acknowledge our own worth, recognize our good qualities and develop self-belief in the skills and talents we’ve cultivated. When we have that – dignity and self-respect, without needing everyone to like us – FOPO is less of a concern.Self-reflection is most effective in community: “When we try to self-reflect alone, we sometimes ruminate,” said Ira Bedzow, PhD, executive director of the Emory University Purpose Project. “But when we self-reflect with people that we trust … (it) allows us to hold ourselves accountable to different ways of seeing and different ways of hearing and different ways of being.”Opening up about our experiences and listening to others are skills we can develop, Dr. Bedzow said.He invited students to participate in what he called a “fishbowl exercise,” where four students sat in a small circle, surrounded by a dozen or so students forming a larger circle. Those in the inner circle answered such questions as: “What stops you from being you today?” and “What helps you feel most like you?”Within minutes, the group in the small circle (the fishbowl), were sharing intimately about their life challenges as those in the outer circle nodded in understanding.After the exercise, one participant said, “I felt like I wasn’t alone, that it wasn’t just me who feels that way.”Another remarked on how “personal” it felt to share face-to-face with others, even strangers.Don’t let AI crush your creativity: Theoretical neuroscientist Vivienne Ming, PhD, has been studying artificial intelligence for more than 20 years. And while she said “it’s reasonable to be concerned” about the fast-growing technology, it can also help humans become better problem-solvers when used strategically.“The smartest thing on the planet today are humans and machines working together creatively,” Dr. Ming said. “What gets more valuable in humans as machines get smarter? Our ability to explore the unknown.“Your unique voice is literally your value to the world … but most of us for most of our lives have been taught to not be unique,” she continued. “Be your own person. Celebrate being different. It is genuinely, measurably, truly valuable.”In a breakout session called “Phone Detox? IYKYK: Living Your Story IRL” led by Don Grant, PhD, students shared their frustrations with AI compromising academic work, art and creativity.“Art is a translation of human experience,” one participant said. “When people use AI, they diminish their own human experience.”Dr. Grant urged them, as “the last generation to remember a world before AI,” to remember the power of imagination and creativity – and to act on it.Remember that social media distorts perceptions: Stuart B. Murray, PhD, PsyD, who directs the Eating Disorders Program and Translational Research in Eating Disorders Program at UCLA, asked the students in his breakout session to take a spontaneous selfie and edit it to conform with society’s beauty standards. All 20 girls in the room immediately got to work, thickening their hair, slimming their faces, plumping their lips.“The pressure to look like what we present on social media can be crippling,” Dr. Murray said. “We now know that social media use is part of a causal pathway into an eating disorder.”Adolescents and young adults are most at risk of developing an eating disorder, he said, with one in three students on college campuses exhibiting clinically meaningful eating-disorder symptoms. More than 4 million people in California will have an eating disorder in their lifetime.Even for those who don’t develop anorexia or bulimia, the ubiquity of modified images online distorts what we consider normal, making us feel worse about ourselves. Remembering that, he and other speakers said, might inspire us to log off occasionally and spend time in the real world with people who love us as we are.
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Black Rain and Health Fears After Strikes on Iran Fuel Depots
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Human Brain Cells Run New Data Centers in Singapore, Melbourne
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Myomo and Elevance Health Agree to Contract for Multi-State Network Participation
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Scientists discover a brain signal that may trigger autism’s domino effect
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Bringing advanced neurological care to South Texas families - UT Health San Antonio
“We’re not only treating conditions — we’re caring for people across the full spectrum of brain health. When someone hears the words, “You have ALS,” or “This may be dementia,” life changes instantly. Questions come faster than answers, appointments multiply and the future feels uncertain. For patients and families navigating that uncertainty, UT Health San […]
Your Bird Isn’t Just Copying You — The Brain Science Behind How Birds Learn to Sing
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