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Team's prediction task compares GPT-4o with classic machine learning
Large language models have been functionally opaque. Seeking transparency, a team undertook a comparison with traditional machine learning.
City Hall visit, packed entertainment slate highlight 2026 HBCU Swingman Classic schedule
Major League Baseball today announced the pregame and philanthropic details for the 2026 HBCU Swingman Classic presented by USA Baseball, highlighted by a team visit to City Hall, Philadelphia Mayor Cherelle L. Parker’s first pitch, uniform patches honoring HBCU legend Roger Cador and pregame entertainment by Grammy-Award winner Durand Bernarr
In another 250 years, what will be considered an American classic?
NEW YORK – What makes a Great American Novel? Which books deserve to be called classics? You may think of the books you read in school, like F.
Lil Wayne a no-show for concert that was supposed to kick off his tour
The performance in Bangor, Maine, was set to be the first of his 20 Years of Carter Classics shows.
Discover the Entertainment at Le Mans Classic Legend 2026
Le Mans Classic Legend (2–5 July 2026) transforms the 24 Hours of Le Mans circuit into a world where heritage, music, cinema, the French art of living and the a
Sony will cease production of discs for new PlayStation games in 2028
New games sold for PlayStation consoles will only be available digitally and won’t be sold on discs effective January 2028, Sony has announced. The move applies to all PlayStation games released from that point on, including those made by Sony and those released by third parties. The PlayStation group calls the change “a natural direction for Sony Interactive Entertainment to adapt to consumer trends as the general preference for digital media significantly outpaces physical discs,” according to a PlayStation blog post reviewed by Game File in advance of its publication. As movies, TV and music have shifted from physical media to an age of downloads and streaming, Sony’s move could speed the demise of physical media in a gaming. The industry has offered consumers games via cartridges, cassettes, floppy discs, CDs, DVDs and Blu-Rays across a 50-year stretch. Sony has been reporting to investors in recent years that PlayStation games have been increasingly purchased as downloads, not as discs. The most recent figures show nearly four in five purchases of full games for PlayStation 4 and PlayStation 5 were purchased digitally in the past year. Stats like that may cause today’s news to carry an air of the inevitable. But Sony’s declaration for 2028 is still likely to produce a shock, as the biggest gaming platform on the planet that uses game discs leaves them behind. Discs going away, but the fate of game boxes is unknown Sony is committing to still selling games in physical retailers even after they drop discs in 2028. Just how those games will be sold—in boxes with codes inside, as cards marked with digital redemption codes—is unclear. Digital games will also continue to be sold in the online PlayStation Store. New games released for PlayStation consoles prior to January 2028 will be unaffected by the policy change, Sony says. That means the PS5 games of 2027, be they a new Madden, a new God of War, a new Call of Duty, a new Sly Cooper (one can dream?), would still potentially be offered on disc. PlayStation 6 implications Sony’s timeline for a transition to a no-disc era will also spin up more speculation about the timing and configuration of Sony’s next-generation console, the probable PlayStation 6. “This pretty much guarantees that PS6 won’t arrive until 2028 at the earliest,” Piers Harding-Rolls, senior games research analyst at Ampere Analysis tells Game File. Harding-Rolls also concludes from today’s news that “the base version of a PS6 will not include a physical media drive,” as Sony looks to keep costs down on the device. Sony itself is saying nothing about the PS6 today: not its timing, nor how it might or might not support internal or external disc drives in order to run disc-based PS4 and PS5 games, should the console be backwards compatible. The many signs this was coming Industry support for games being released on physical media has been waning. As has consumer interest in them. PC games effectively went all-digital years ago, thanks to the popularity of playing games through Steam and other digital storefronts. The Covid-19 pandemic and the lockdowns that kept much of the global population home helped shift shopping patterns toward downloads. Sony’s own data shows PlayStation game downloads being an uncommon consumer choice a decade ago and now becoming the norm. On consoles, physical media has been in such decline that Sony and Microsoft both launched their current gen Xbox Series and PS5 consoles in 2020 with cheaper versions that lacked disc drives. In early 2024, Phil Spencer, then head of Xbox, told me that ““[w]e ship games physically and digitally, and we’re really just following what the customers are doing.” He added that the game industry had become an outlier in still supporting disc-based entertainment, even as movies and TV have bailed on discs in favor of downloads and steaming: “Gaming consoles themselves have kind of become the last consumer electronic device that has a drive. And this is a real issue, just in terms of the number of manufacturers that are actually building drives and the cost associated with those. And when you think about cogs that we’re going to go put in a console—and as you have fewer suppliers and fewer buyers—the cost of the drive does have an impact.” Last year, the Nintendo’s Switch 2, which uses cartridges rather than discs, introduced the concept of game-key cards, which are physical media that contain no game, just a prompt for a download. Even disc-based games aren’t what they once were, now frequently containing just stubs of games rather than the whole thing. The website Does It Play has tested over 3000 games and found that, for example, that the disc version of this year’s hit 007: First Light, only contained the game’s first mission, with the rest needing to be downloaded. Beyond all that, last week brought the news that Grand Theft Auto VI, likely the biggest game launch this decade, will debut for PS5 and Xbox Series without a disc-based version. Today’s big news comes to you for free. Game File is a reader-supported publication. To receive new posts and ensure more of my work is possible, please consider becoming a free or paid subscriber. Subscribe Discs helped define PlayStation However the trends in entertainment may be going, it is still remarkable to see PlayStation ditch discs given their importance in PlayStation history: In the late 1990s, the first PlayStation’s support for games on relatively cheap CD-ROMs instead of traditional game cartridges allowed the upstart console to outmaneuver cartridge-based systems from Nintendo and Sega, as it drove down game prices down in the process. (The cheaper disc format even prompted Final Fantasy VII maker Square to taunt Nintendo in a magazine ad, saying that if the game was “available on cartridge, it’d retail for around $1200.”) PlayStation devices often doubled as machines for watching movies and TV on the latest disc-based formats. In the late 2000s, for example, Sony’s pricy PS3 gained traction as a go-to device for playing then-novel Blu-Ray discs. In 2013, Sony effectively roasted the digital game-sharing restrictions proposed by rival Microsoft for its upcoming Xbox One console by showing how games could be shared for the then-upcoming PS4. In a 21-second clip that has over 20 million views on YouTube, one PlayStation executive simply handed a game box—presumably with disc inside—to another, who said “thanks.” Sony’s possible motivations The PlayStation announcement today cites “consumer preferences” and a shift away from discs among “the broader entertainment industry,” but does not delve into the decision-making process that brought Sony to this point. Sony is not discussing the economics of this move (I asked!), but there are a number of potential factors: Abandoning discs will spare Sony the cost of manufacturing and shipping them, which analysts and industry veterans I spoke to said could account for $1 or so of a game’s retail price. For first-party games, that’s direct savings for Sony, though the amount is limited by the winnowing percentage of people who were even buying the disc-based versions. For third-party games, Sony could pass the savings on to partners or just retain the better profit margin for themselves. As the 2024 comments from Phil Spencer alluded to, leaving discs behind could mean leaving disc-drives behind, allowing Sony to produce consoles more cheaply. Switching to digital-only for games could diminish the risks of copies of new games leaking. It would also seemingly make second-hand sales of used games impossible, pushing more people to buy their own copies of games. These economic benefits for Sony could be boons for the games industry overall, Ampere analyst Piers Harding-Rolls tells Game File. Among other things, it could free publishers and retailers from having to worry about securing an inventory of game discs when trying to sell games, he noted. “If there is a way to streamline the business of games retail, I generally think it’s a good thing for the industry as it removes unnecessary costs,” Harding-Rolls said. “This will help offset pressure on margins from other directions – development and staffing costs for example.” Should the industry shift from game boxes that contain discs to smaller, cheaper game cards, Harding-Rolls said, that reduces pressure on publishers and retailers. “The advantage of everything going digital for the industry is that sales can be tracked much more easily and there is less commercial risk for publishers wanting to continue selling via retail,” he said. The shift to no discs will also likely impact game development timelines, as developers will no longer face the same urgency to have a build ready to submit to PlayStation for the production of a disc, as industry experts noted around GTA VI’s no-disc news last week. Instead, projects may gain weeks of development time, in the event delivery deadlines for platform approval move closer to release date. Preservationists’ likely worries While millions of gamers have shifted to digital, there are still people who associate game discs—and only game discs—with actual ownership of PlayStation games. That portion of the gaming community spoke up last week about wanting to buy a version of GTA VI that they could hold in their hands, could lend to a friend and could potentially pop into a well-preserved PS5 console three decades from now and still see it run. Such gamers didn’t want to worry that they’d merely purchased a digital copy that could lose access to the game if, say, the company behind the game someday turns of the servers that transmit downloadable copies. Digital copies of games are inherently less long-lasting, because consumers aren’t actually buying a game (on a disc), just buying access to the game. The fine print in online gaming shops notes this, as does a recent law that went on the books in California in 2025. That lasw requires game publishers doing business in the state to refrain from words like “sell” when offering digital copies of games, unless they explicitly tell consumers that what’s being sold isn’t the game itself but a potentially revocable license to access it. A Sony spokesperson noted to Game File that “[w]ith all digital content, including games, movies, and music, players are purchasing a personal license for non-commercial use.” Regarding the fears of PlayStation games being lost to time in an all-digital era, the rep also noted that Sony remains “committed to delivering experiences from past generations to the new platforms our players are using.” They noted that PlayStation has used emulation and remasters to keep offering its classic games to modern gamers. It’s true that many consumers have become accustomed to not having physical copies of new music albums or movies, but the relative precariousness of digital copies of games is in fact being highlighted today by…. Sony’s other big announcement: the upcoming closure of the PS3 and PS Vita online stores Sony said today that it will be closing the online marketplaces for its PlayStation 3 console and PS Vita handheld in most countries in July 2027 (sooner elsewhere: August 2026 for the PS3 store Mexico, Honduras and Nicaragua; late 2026 for PS3 in other Latin American countries and the Middle East). “We know this news may be disappointing to PS3 and PS Vita players who hold a special place in their hearts for this generation of gaming,” Sony said in its announcement, saying the move “was not an easy decision for us to make.” Sony said that PS3 and Vita marketplaces “are no longer able” to support modern commerce systems, prompting a “need” to close the shops and focus on more modern PlayStation platform stores. The news may spark some deja vu. Sony announced back in March 2021 that it planned to take the PS3, Vita and PlayStation Portable marketplaces offline that summer. The move would have caused some 2,000 digital-only games to become unavailable for new purchasers, according to a VGC analysis at the time. Fans complained loudly. By April 2021, Sony walked back the PS3 and Vita shop closures, with then PlayStation boss Jim Ryan saying “it’s clear that we made the wrong decision here.” This time around, Sony is giving a longer notice period in most regions. The closure of those stores is still likely to cut off access to new purchases of digital-only PS3 and Vita games. The current PlayStation 5 marketplace sells PS5 and PS4 games, as well as a selection of PS1 and PS2 games. It does not sell PS3 games, because games for that platform can’t run on the system (some are offered via a PlayStation Plus streaming option). Vita games also aren’t sold via PS5. Sony says digitally purchased PS3 and Vita games will be downloadable after the stores’ shutdowns “for the foreseeable future.” Sony’s move contrasts with Microsoft’s Xbox platform, which continues to sell and support games from all four Xbox console generations. But it puts it in line with Nintendo, which disabled purchases in the marketplace for its Wii console (a contemporary of the PS3) in 2019. Nintendo discontinued purchases in the online shop for its 3DS portable (a contemporary of the Vita) in 2023. The big questions about Sony’s 2028 post-disc era Will Microsoft follow suit, ending support for new disc-based games on Xbox platforms and therefore all game consoles, too? Whether Microsoft does or not, will third-parties that can no longer release games on discs for PlayStation, simply ditch the disc options across the board? Given the GTA VI no-disc experiment launching this November, will more game publishers decide to forgo disc-based offerings even in 2027? How will no-disc PS5/6 games be packaged and sold in brick-and-mortar retail stores? What becomes of game sharing in an all-digital era? Will Sony modify its current set-up, which currently allows some sharing of digital games across a pair of consoles, to allow more casual lending? (See for example, Nintendo’s year-old system of letting players lend a digital game to another player in a “family group” for up to 14 days.) Will there be a version of a PS6 with a disc drive? Or will a drive be offered as an add-on? And how will gamers who want to retain access to PS4/PS5 disc-based games react to whichever configurations Sony chooses to offer? What will the final disc-based PlayStation game be?
2026 John Deere Classic tee times, TV coverage, viewer's guide
Tee times, TV coverage and viewer's guide for the John Deere Classic at TPC Deere Run in Silvis, Ill.
New music festival hits Seattle Center this weekend
The first-ever Seattle Center Classical festival, a free, open-to-the-public classical music event, takes place Sunday.
Netflix and Superheroes Are Having a Rough Stretch on Streaming....
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) I have a quick prediction before we start today’s article: You might see this data in future news articles. Not my specific charts or analysis, but the core trend I’ve been monitoring—Netflix is having a lackluster Q2—will become inescapable. Often, folks want to know “What does the data say?” Well, that’s what it says. I haven’t seen this analysis hit the trades really yet, but I have a feeling some other outlets are going to start making this case soon. Remember, you read it here first. You probably have read about the problems facing superhero films at the box office this weekend. Well, this week, I explore whether superheroes are dying on TV as well! And the data says: definitely maybe! We have a lot to cover in today’s Streaming Ratings Report, which covers the two weeks of 18-May and 25-May. Today, I’m just looking at TV, like Netflix’s disappointing Q2, superhero shows underwhelming, a few TV shows dropping off the charts, The Pitt finally ending its epic run on the viewership charts (and whether “view counts” change its status as one of the biggest shows of all time), all the flops, bombs and misses, and a whole lot more. Tomorrow, I’ve got a great rundown of the film side of things. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, Showlabs, TV Time trend data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of May 18th to May 31st, 2026. You can find a link to my terminology here.) Subscribe Television - Netflix’s Q2 Slump Continues Having analyzed streaming ratings for going on half a decade, I have learned to trust my gut, but I’m always relieved when I can find actual data to back it up. For example, after a string of very popular shows like Stranger Things, Bridgerton, The Lincoln Lawyer and The Night Agent came out, week after week, in January and February, my gut wondered if Netflix had enough new and returning TV shows to sustain them throughout the year. Since then, Netflix’s post-March slate of shows has not impressed me. This week seemed to feature a potential new hit, but then, like a classic Duffer Bros. TV show, there was a twist. I speak of The Boroughs, Netflix’s latest (and last) Duffer Bros. produced show. The pitch is “Stranger Things with older actors”. And it topped the Nielsen charts: With just two weeks of viewership, The Boroughs would have been a top 25 debut show last year: But here’s the twist: Netflix has already cancelled The Boroughs! What happened? Likely a few things. First, the show didn’t do as well globally as it did in the US. As What’s on Netflix showed, it lagged behind several other shows that got cancelled. Second, its completion rate was likely low; after an initial burst of interest, it quickly dropped off on the Samba TV and Luminate charts. Third, the Duffer Bros. left Netflix for Paramount, and that may have factored into Netflix’s decision here. (Though I tend to believe that if a show is doing well, Netflix would have kept greenlighting seasons.) Still, just because I can explain why Netflix may have cancelled this show doesn’t mean I’m justifying it. In particular, as I’ve noted before, Netflix is losing a lot of their bigger shows as they reach their natural ends, and they need to replace those shows. This show had the hallmarks of a big new genre show, and it’s their biggest hit of the last few months (in the US at least), but now it’s done. Netflix’s other show this week—The Four Seasons, the second season of the “hit” show from last year—definitely disappointed. Its sophomore season had about half the viewership of the first, only 12.7 million hours. It also only had a two week run on Samba TV, and its numbers were all down on Luminate too. In other words, even with two successes, the Q2 slump for Netflix looks real: I could add to the list of disappointments: Both Lord of the Files and Man on Fire had short runs on the Nielsen charts. Running Point’s sophomore season also opened to about half its viewership, similar to The Four Seasons. A Good Girl’s Guide to Murder’s second season—see below—didn’t even make any of the three viewership charts I track, unlike the first season. Netflix is absolutely having a dismal second three months of 2026. If this Nielsen data is any indication, and I think it is, I think this will show up in Netflix’s engagement report, and maybe even their financial outcomes. And the rest of June doesn’t look much better. We have two hit shows coming back—Sweet Magnolias, one of their quietest big shows, and Avatar: The Last Airbender, a big hit for them in 2024—but the other big swings are limited series crime thrillers i.e. no future season potential. Like I said above, sometimes when I uncover a juicy nugget like this, other outlets end up writing very similar articles mimicking the data without credit. We’ll see if that happens this time! Share Television - The State of Superhero Shows on Streaming When I first heard the pitch for Spider-Noir—a Sony TV show on Prime Video that binge-released eight episodes first on MGM+ then on Prime Video two days later—I had my doubts. It’s a live-action Spider-Man show set in the 1930s, starring Nicholas Cage, based on a cameo of a character in Spider-Man: Into the Spider-Verse. No, seriously, that’s the pitch. That could either go terrifically well or horribly wrong. Great because, Spider-Man. He’s the biggest superhero we have. I’ve seen tracking numbers that put the new _Spider-Man: Brand New Da_y as the blockbuster of the year and initial pre-sales back that up. And yet this Spider-Noir pitch feels very esoteric. (Also, the eight-episode binge release feels very “Amazon copying Netflix” again.) So what’s the data say? And what does this say about the future of superhero shows?
Hollywood celebrates Mel Brooks' 100th birthday
Mel Brooks' 100th birthday is being celebrated by friends, fans, and the whole of Hollywood.
Retro Recap: All The Classic Gaming News From The Past Week (June 28th 2026)
Sonic pinball! Retroid Pocket Nova! Star Fox 64!
‘Odyssey’ fever grips the Classics world
Fans of the ancient world are seizing their moment with the release of this summer’s blockbuster.
‘Odyssey’ fever grips the Classics world
(CNN) — As fans of Christopher Nolan eagerly await the July 17 release of his take on “The Odyssey,” a different kind of enthusiast is also bristling with anticipation: scholars
Fidelio: Classical music meets politics
Vitali Alekseenok is passionate about classical music and politics. He is actively involved in Ukraine, advocates for a free Belarus, and conducts Beethoven's opera of freedom, 'Fidelio,' at the Deutsche Oper am Rhein.
Cool Desert Nights returns to Richland with classic car show, entertainment
RICHLAND, Wash. — One of Tri-Cities’ biggest events, Cool Desert Nights, returns to Richland with a weekend of classic cars, live entertainment, food and community events.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Entertainment this week: Paul Thorn, Hike for Hope and more
Friday, June 26 Annual Ian Casey Classic – Tahoe Donner Golf Course. Our most popular event of the year, a full field of 130+ golfers will team up in foursomes and hit the links to...
'Grease' star Didi Conn recalls the cast 'being horny' during production of the classic musical
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Revealed – Warhammer: The Old World Made to Order miniatures
Classic baby Dragons, Ogres, and more return to the World of Legend.
GTA 6 Ultimate Edition Pre-Order Details Confirm Major New Gameplay Features, Giving Players A First Look At Safehouses And Custom Vehicles
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Scientists catch classical space-time crystals moving like Majorana quasiparticles
A research team from Hiroshima University, the University of Colorado, and other collaborators have demonstrated that space-time crystals—exotic structures that, under external drive, loop endlessly through ...
Samsung Galaxy Watch Ultra 2 redesign leaked in high quality official press renders
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Sega Announces Two Sonic Game Collections For Switch
Including a "Modern" and "Classic" collection
Sonic Racing: CrossWorlds free character updates Classic Sonic, Axel, and Amigo announced
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"It's like lightning in a bottle" - Star Wars Galactic Racer devs spill the beans on why it's so hard to make a game as good as Burnout Paradise
Matt Webster and Kieran Crimmins recollect the creation of a racing classic, and how they're trying to strike gold twice.
Scientists create optical skyrmions using a two-century-old light phenomenon
Nanyang Technological University, Singapore (NTU Singapore) scientists have used a classic optical phenomenon known as the Poisson spot to create stable patterns of light called optical skyrmions, which ...
Wilder’s wit is timeless in marvelous ‘Matchmaker’ at APT
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Jon Stewart blames JD Vance's Iran negotiations failure on a nose-picking incident: 'Classic diplomatic faux pas'
'The Daily Show' host Jon Stewart blames the failure of Vice President JD Vance's Iran negotiations on a nose-picking incident seen in viral video: 'Classic diplomatic faux pas.'
‘The Craft, Art and Science of Classical Guitar’ at Buttonwoods
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22nd annual Car-B-Que classic cruise-in returns June 22 with food, entertainment, games, raffles and music
OGDENSBURG — The St. Lawrence County Chamber of Commerce will host its 22nd annual Car-B-Que, a classic cruise-in and family event featuring food, entertainment, games, raffles and music. The …
Yamashita tops Woad in playoff to win Meijer LPGA Classic
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Science Writer Takes Aim at Many Universes Theory
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5 Companies That Make Classic Car Bodies When The Automakers Won't
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Twins 16, Diamondbacks 8: The Beautiful Game
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Sunday Morning Showdown: Vacheron Constantin Overseas Self-Winding Vs. Girard-Perregaux Laureato Fifty 39mm
✓ Sunday Morning Showdown ✓ Vacheron Constantin's Overseas takes on Girard-Perregaux's Laureato Fifty ✓ Two stylish classics ✓ Vote here! ✓
Galaxy Watch 9 and Ultra 2 leaks reveal more changes, no Classic after all [Gallery]
Ahead of Samsung’s July event, new leaks are revealing a few more details about Galaxy Watch 9 and Galaxy Watch...
CT Culture Corner: Shepard Fairey exhibit, Somi concert this week
The artist responsible for Obama's "Hope" poster and the "Obey" graphic comes to New London Museum, Irish dance in Torrington and who wrote the classic "Danny Boy," anyway?
Doom Composer Bobby Prince Dies at 81
Robert Caskin 'Bobby' Prince III, the composer behind classic '90s games like Doom and Duke Nukem 3D, has died at 81.
Doom Composer Bobby Prince Has Died
Bobby Prince, composer for Doom and other classic shooters, has died.
Colman Domingo explains his 'wild' theory about Hitchcock classic 'Rear Window'
Colman Domingo doesn't play about his favorite films, but he does hold one playful theory about the best of his best — 'Rear Window,' which blew the mind of TCM host Ben Mankiewicz.
Colman Domingo explains his 'wild' theory about Hitchcock classic “Rear Window”
Plus, the "Disclosure Day" star tells TCM why he considers Jimmy Stewart his "North Star as an actor."
Arts and Entertainment Agenda, June 19-25
Food & Wine Classic in Aspen, June 19-21 Chefs, vintners and food lovers converge for the 2026 Food & Wine Classic in Aspen this weekend from June 19 to 21. The leading culinary event has...
Trying BLT sandwiches at Subway, Jimmy John's, Jersey Mike's; best
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Fed's Kevin Warsh signals change with new task forces
New Fed chair Kevin Warsh is using classic corporate strategies to guide monetary policy changes and signal a leadership shift.
Xbox is porting two classic Call of Duty games to PlayStation — and they're coming very, very soon
Call of Duty: Black Ops and Black Ops 2 will soon finally be playable on modern PlayStation systems.
San Diego County Fair brings classic treats, entertainment to Rady Children’s Hospital
The San Diego County Fair brought music, entertainment, and classic fair treats to patients and families at Rady Children’s Hospital, providing a sense of normalcy for those unable to attend …
FOX Sports' BIG NOON KICKOFF Heads Across the Pond for Inaugural Union Jack Classic From Wembley Stadium
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‘The Rocky Horror Picture Show’ Coming to Las Vegas’ Sphere
Sphere Entertainment will "enhance" the 1975 cult classic for the massive venue.
In 2018, Scientists Recorded An Orca Mimicking Human Speech For The First Time
Included in the repertoire are such human classics as "hello", "bye bye", and a long farting noise.
Veteran Sire Social Inclusion Returns To Pennsylvania In 2027
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Sally Field couldn’t understand this classic Hollywood actor on set: 'I don’t know if he was stoned or what'
Sally Field is revealing the classic Hollywood actor who she just couldn't understand at all whenever they interacted on set.
Haiti’s World Cup dream is bigger than sports
Official MLS highlights, classic matches, video series and features.
Microsoft's new Outlook takes 10 seconds to do what Outlook Classic does instantly on Windows
New Outlook takes 10 seconds to show an email after clicking a Windows 11 notification. Outlook Classic does it instantly. Here's why.
Samsung's iPhone Ultra rival reportedly more crease-free than the Galaxy Z Fold8 Ultra thanks to thicker UTG
An industry report from South Korea suggests a significant difference between the more compact and wider Galaxy Z Fold 8 on the one hand, and the "Ultra" version of the classic foldable form factor on the other. According to the report, the wider iPhone Ultra competitor from South Korea appears to be significantly less prone to creases than the Galaxy Z Fold 8 Ultra.
Tomb Raider's new star reveals her 'classic' and 'unapologetic' approach to Lara Croft
Alex Wilton Regan wants to bring out Lara Croft's confident side again
📸 This week’s kit news 👕
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Art, not politics, explains the achievement of ‘Death of a Salesman’
Liberals say Arthur Miller’s classic, thriving on Broadway, indicts capitalism. No, it captures human pathos.
Ohio lawmakers send math intervention bill to Gov. Mike DeWine with science of reading exemption
An academic intervention bill that would also exempt Ohio’s classical schools from teaching the science of reading curriculum is heading to Ohio Gov. Mike DeWine’s desk.
Principal Charity Classic: Agronomists use science to prepare greens at Wakonda Club
Agronomists play a crucial role in golf tournaments, using advanced tools and techniques to ensure greens are ready for competition at the Principal Charity Classic.
Kenan Thompson explains how sharing an office with Colin Jost for 8 years led to a classic 'SNL' sketch
'Saturday Night Live' star Kenan Thompson explained how a famous sketch came about because he shared an office with Colin Jost. They were 'office mates for like eight years.'
🏆 Y! Sports AM: Best Stanley Cup ever?
It's starting to feel like we might be witnessing an all-time classic.
“The Magic Mile” Happy Hour Show Returns to Headline Long List of Free Entertainment for Race Fans at New Hampshire Motor Speedway
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A classic brain test exposed AI's biggest weakness
Researchers gave top AI models a classic attention test used in psychology and found a major flaw. While the models could correctly name colors in short lists, their performance deteriorated sharply as the task became longer and more complex. Some leading systems fell from over 90% accuracy to nearly complete failure.
TST Best Bets: June 9, 2026
It’s been classic after classic through these Stanley Cup Finals, and if the Vegas Golden Knights come out of this series with their second ever world championship, then Game 3 will be immortalized forever as the night they survived the impossible. After squandering a 4-0 lead, Vegas pulled out a miraculous victory in double overtime to take a 2-1 lead in the series on their home ice. Now in Game 4, the Carolina Hurricanes face a do-or-die situation, as a loss would send them back home for Game
Movie Review: ‘Disclosure Day’ is classic Spielberg
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A journey between two worlds begins in TALES OF ETERNIA REMASTERED this October
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Final Fantasy Resonance Preview: Final Fantasy Goes HD-2D, and It's Glorious
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Ringo Starr talks new tour and why he still loves drumming
DENVER — Even at 85, Ringo Starr eagerly awaits each new tour with his All-Starr Band not just to play his own material, which includes Beatles classics such as “Yellow
The “Romy and Michele” sequel is finally happening
After years of talk, the long-awaited follow-up to the 1997 cult classic has begun filming.
Classic race planned in place of excluded sidecars
The Southern 100 Club says it plans to allow classic machines to race instead of modern sidecars.
New MkIV Space Marines deploy to the Horus Heresy
Classic power armour reborn with updated miniatures for Warhammer: The Horus Heresy.
Stealth classic Thief: The Dark Project is getting the remaster treatment from retro specialist Nightdive Studios
After successfully tackling System Shock and its sequel, retro specialist Nightdive is remastering another classic immersive sim.
Thief: The Dark Project Remastered announced for PS5, Xbox Series, Switch 2, PS4, Switch, and PC
Publisher atari and developers Nightdive Studios and Eidos Montreal have announced Thief: The Dark Project Remastered, a modern revival of the 1998 classic from Looking Glass Studios. It will launc…
Nintendo Switch Owners Can Now Play Their Classic Wii And GameCube Games - Here's How
Classic GameCube and Wii games are now available on the Nintendo Switch. Find out how to easily access the games on your console for free or by subscription.
Crazy Taxi: World Tour Revives an Arcade Classic in 2027, But There's a Catch
Ya ya ya ya ya?
Golden Knights regain Finals lead despite late flair for the dramatics
The only word that could properly describe the 2026 Stanley Cup Final so far would be unhinged and Game 3 was easily the craziest game of a classic series.
Three Classic Hitman Games Are Getting Remastered For Xbox In 2027
"Three titles, one package"
HITMAN Classic Trilogy Remastered announced for PS5, Xbox Series, and PC
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Welcome Back, 47: HITMAN Classic Trilogy Remastered Revealed - Coming 2027
Saber Interactive has partnered with IOI for HITMAN Classic Trilogy Remastered, boasting enhanced visuals, improved performance, and new features, all while preserving the systems, tone, and freedom of the iconic original trilogy.
The Wolf Among Us Remastered, The Wolf Among Us 2 announced for Nintendo Switch 2 and Switch
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Sounds of music: Surry Barn to host summer concerts
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Mighty Cuphead Adventure announced, new Cuphead game on the way
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Black Ops 7's New Classic Mode Seems to Fix a Lot of Issues Players Have With the Game
Call of Duty: Black Ops 7 players are having a blast with the games new mode, Black Ops Classic.
Peabo Bryson dead: R&B singer known for Disney classics was 75
R&B singer Peabo Bryson died Tuesday in Marietta, Ga., after suffering a stroke over the weekend, according to his familiy.
PS Plus Extra Confirms Classic RPG Property for the First Time Ever on Consoles
RuneScape, anyone?
Rayman Legends Retold Launching October 1
The reimagined adventure of the beloved 2013 classic features stunning 3D visuals, a new story, thrilling dragon rides, new musical stages, and more.
Scientists discover inherited traits that break Mendel’s Laws of genetics
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Classic Monaco Grand Prix images through the years
A selection of the best images of the Monaco Grand Prix, starting with the first F1 championship season in 1950.
10 Indie Games From 2026 That Feel Like Cult Classics Already
As we approach the midway point of 2026, let's take a look at some under-the-radar indie gems that already feel like cult classic video games.
The Ferrari Luce backlash is making the brand's classics more valuable
The backlash to Ferrari's new EV, the Luce, has been good for one collector, stirring fan passion and driving up the value of classic Ferraris.
AC Cobra GT Coupe Puts a Fixed Roof on the Classic for the First Time
AC Cars has been around for 125 years, and it's been making Cobras for just over half that time. But it's never made one like this.
Urgent alert: a mysterious asteroid forces surprise action from astronomers - Futura-Sciences
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Duke Basketball's Opponent Set for 2026 Jimmy V Classic
The Blue Devils will play in the 2026 Jimmy V Classic.
A star Is born: João Fonseca outlasts Novak Djokovic in instant classic
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Key Chemistry Question Answered, No Quantum Computer Required
Do we need quantum computers to fully understand complex chemical reactions? A new result, decades in the making, shows the surprising power of ordinary “classical” machines.
Galaxy Watch 9 leak hints at three new models, plus a borrowed feature from Google
Samsung's Galaxy Watch 9 may get the Pixel Watch 4's best trick
Scientists Found a Black Hole That Breaks The Rules of Astrophysics
"It’s a paradigm shift, a total revisiting of the classical scenarios.”
Samsung Galaxy Watch 9 codenames suggest there will be a new Classic this year
Despite recent rumors to the contrary, it looks like we may get a Galaxy Watch 9 Classic this year, after all.
Cocktails you should order more often, according to bartenders
From gin 50/50 martinis to classic daiquiris, there are a number of cocktails that bartenders wish they saw people order more often.