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If Trump Attends Oral Arguments, It Would Be a Presidential First
The president previously mused about attending the Supreme Court’s arguments over his sweeping tariffs, but ultimately did not make an appearance.
Odell Beckham Jr., Giants appear to share mutual interest: How sides can make reunion happen
The New York Giants and Odell Beckham Jr. have a chance to reunite under John Harbaugh.
Surprising study shows Alzheimer's may start in the body instead of the brain, a discovery that turns medical science upside down
Alzheimer’s disease may begin outside the brain, with inflammation in organs like the skin, lungs, and gut decades before symptoms appear.
Title X funding for reproductive health care could lapse due to Trump admin delays
Some clinics that rely on Title X grants to provide birth control, cancer screenings and STI testing are making contingency plans as the government appears likely to miss its deadline.
Wikipedia founder and GBBO star to appear at Cheltenham Science Festival
Wikipedia founder Jimmy Wales and Great British Bake Off finalist Josh Smalley will be appearing.
Oracle cuts staff, including from its health business
Rumored for weeks, a reduction in force across Oracle business units, including Oracle Health and AI employees, appears to be hitting health IT developers in Kansas City and others worldwide.
Oracle cuts staff, including from its health business
Rumored for weeks, a reduction in force across Oracle business units, including Oracle Health and AI employees, appears to be hitting health IT developers in Kansas City and others worldwide.
Oracle cuts staff, including from its health busines
Rumored for weeks, a reduction in force across Oracle business units, including Oracle Health and AI employees, appears to be hitting health IT developers in Kansas City and others worldwide.
Dallas Cowboys 2026 NFL Draft Preview
The Dallas Cowboys in 2025 turned out to be quite a talented team, but only on one side of the field. The offense ranked among the best in the NFL. However, the team scored as many points as it gave up. Pick any defensive stat, and the Cowboys likely ranked in the bottom five in […] The post Dallas Cowboys 2026 NFL Draft Preview appeared first on The Lead.
Apple Intelligence rolling out now in China, per user reports
Apple Intelligence launched in 2024, but now after a nearly 18-month wait, Apple’s first AI features appear to be rolling out in China too.
Mark Sanford makes a last-minute bid to return to Congress in South Carolina
Sanford once built his career in the district, then won the governor’s office. His time as governor was defined by his disappearance and trip to Argentina to see his lover.
Bluesky Users Respond With Overwhelming Disgust to Platform’s New AI
Bluesky's latest foray into AI isn't exactly sitting well with what appears to be the vast majority of the platform's user base.
‘Tap to Share’ gesture for Quick Share leaks in Samsung’s Android 17 update
Google appears to be working on a new tap-based gesture for Quick Share that utilizes NFC to trigger file sharing,...
Monster black holes are silencing star formation across the universe
A blazing supermassive black hole can influence far more than its own galaxy. Scientists found that quasars emit radiation strong enough to shut down star formation in nearby galaxies millions of light-years away. This could explain why some galaxies near early quasars appear faint or missing. The finding suggests galaxies grow and evolve together, not in isolation.
Scientists stretched a liquid and it snapped like a solid
Scientists have discovered something that seems almost impossible: under the right conditions, ordinary liquids can snap apart like solid objects. In experiments, researchers found that when certain liquids are stretched with enough force, they don’t just thin and flow—they suddenly fracture with a sharp break, much like metal under stress. This surprising behavior appears to be tied to viscosity, not elasticity, challenging long-held assumptions about how liquids behave.
‘Blue Bloods’ Actor & Comedian Alex Duong Dies at 42
He also appeared in 'Everybody Hates Chris,' 'The Young and the Restless,' and more.
Killing off the Regional Transportation District
This column is appearing the same day state Sen. Matt Ball (D) of Denver and his legislative co-sponsors unveil legislation implementing many of the recommendations advanced by last summer’s RTD Accountability Committee. Although it isn’t readily apparent, they have allowed themselves to be enlisted in a plot that will likely lead to the bankruptcy and […]
Kylie Minogue Locked In To Headline 2026 AFL Grand Final Entertainment
“As a Melburnian, I’m so excited to be coming home for the biggest day in the Aussie sporting calendar." The post Kylie Minogue Locked In To Headline 2026 AFL Grand Final Entertainment appeared first ...
JD Vance warns that extraterrestrials are demons: 'I'm going to get to the bottom of this'
JD Vance does not believe that 'celestial beings' who 'fly around and do things to people' are aliens. 'I think they're demons,' the vice president said on a recent podcast appearance, vowing to 'get to the bottom of this.'
Scientists Solve Decades-Long Mystery About Why Saturn Appears To Change Its Spin
Researchers at Northumbria University have used the most powerful space telescope ever built to answer one of the longest-standing puzzles in planetary science – why does Saturn appear to spin at a...
Entertainment Bill on Move in State Legislature
A House bill being considered to allow for the designations of entertainment districts in Osage Beach and Chesterfield appears to be on the move in the state Senate. Sponsored by the 123rd district…
Yet another injury issue has struck a Manchester City defender
John Stones has once again endured an injury-ravaged season for Manchester City. The silky centre-back has only made 15 appearances for Pep Guardiola’s side in all competitions. Injuries have destro...
Millions of boomer small business owners will soon retire. Will their companies just disappear?
It’s likely, but it also could be a boon for a new generation of entrepreneurs willing to take over established operations
Coca-Cola’s yellow caps are back — what they mean and why they’re compared to Mexican Coke
Coca-Cola bottles with yellow caps are appearing on shelves across the U.S., as they do every spring around Passover, and social media is taking notice.
Floyd Mayweather vs. Manny Pacquiao fight could be in jeopardy
Floyd Mayweather still has plans to spend time in the ring in the coming months, but whether it will be with Manny Pacquiao appears questionable.
Utilities, health care costs top Westmoreland County residents’ affordability concerns, survey finds
Utilities and health care are the two expenses Westmoreland County residents worry about the most, a nonprofit community organization’s recent survey on affordability found. With those results in hand, Voice of Westmoreland is organizing residents to appear before the county commissioners in April and share their stories, in hopes of
What would happen to Earth if the sun suddenly vanished?
Earth is habitable due to warmth from the sun. So what would happen if the sun disappeared?
Polar bears are struggling in every aspect of their lives, but scientists are hoping to prevent extinction through genetic management
Polar bears are struggling to survive as Arctic ice disappears, limiting food, reducing habitat, and pushing their ability to adapt.
Stroke triggers a hidden brain change that looks like rejuvenation
After a stroke, the brain may do something surprisingly hopeful—it can “refresh” parts of itself. Researchers analyzing brain scans from over 500 stroke survivors found that while the damaged side of the brain appears to age faster, the opposite, unaffected side can actually look younger. This unexpected shift seems to reflect the brain’s effort to rewire itself, strengthening healthy regions to compensate for lost function.
Phil Weiser wins top spot in Colorado’s Democratic gubernatorial primary at party’s state assembly
Attorney General Phil Weiser’s name will appear first on Colorado’s Democratic gubernatorial primary ballot after his overwhelming win Saturday at the party’s state assembly in Pueblo. Weiser joins U.S. Sen. Michael Bennet in the June 30 primary for the office held by term-limited Gov. Jared Polis. Bennet, who successfully petitioned onto the ballot, didn’t participate […]
Green Bay Packers 2026 NFL Draft Preview
The Green Bay Packers failed to meet the high expectations of their fan base in 2025. The addition of star pass rusher Micah Parsons offered zero relief from a tradition of painful playoff losses. The Packers closed out their 2025 season with a crushing loss to their division rival, the Chicago Bears, following a fourth-quarter […] The post Green Bay Packers 2026 NFL Draft Preview appeared first on The Lead.
What we know about the new 'cicada' COVID-19 variant
Its official name is BA.3.2, but it’s earned the nickname "cicada" because, analogous to the insect’s pattern, it first appeared back in 2024, went dormant for a while, and resurfaced in the U.S. late last year.
Colorado Politics Calendar Mar. 30-Apr. 5
CoPo’s weekly political calendar will help you find political and public-policy events throughout Colorado. It includes candidate and issue campaign events, public policy meetings, court hearings, state and local party conventions, assemblies, debates, rallies, parades, speaking engagements, traveling dignitary appearances, water meetings, book signings, county commission hearings, city council meetings and more. As a subscriber, […]
Scientists discover why your appetite suddenly disappears when you’re sick
Scientists have uncovered how your body actually tells your brain to stop eating when you’re sick. In a new study, researchers found that specialized cells in the gut detect parasites and send signals that ultimately trigger the brain to suppress appetite. This process builds over time, explaining why you may feel fine at first but then suddenly lose interest in food as an infection takes hold.
Impossible Science Live! with World Champion of Magic Jason Latimer
Impossible Science Live! with World Champion of Magic Jason Latimer From bending light with physics, to shaping water with chemistry and walking through solid glass with engineering, World Champion of Magic Jason Latimer’s mind-blowing live show delivers an inspiring message of how “The right question changes everything.” Impossible Science LIVE! expands on Jason Latimer’s inspiring TED Talk “ Seeing Beyond the Illusion of Knowledge ” with family-friendly, mind-blowing illusion entertainment. Uniting his favorite illusions from his illustrious career, Latimer reveals the secret to his magic is not special powers but simply a pursuit of challenging the impossible with curiosity. During your museum visit from April 7-11, 2026, drop into the auditorium for one of Latimer’s shows throughout the day. Shows are included with your Spring Break admission and FREE for museum members. Add a membership to your cart for free Spring Break admission! Available showtimes: 10:30 a.m., 11:30 a.m., 1 p.m., 2 p.m. daily, with a 3:30 p.m. show on Saturday, April 11. Open seating; first come, first seated. About Jason Latimer: Jason Latimer has been featured on television around the world as both a scientist and magician. While Latimer is both a curator of the iconic Fleet Museum in San Diego, CA, and a World Champion Magician his network specials, TV series, and appearances span the globe. Jason has been featured as a science host on the Science Channel, Roku, Amazon, and as a magician on the Syfy Channel, History, BBC ONE, and Japan’s NHK. In 2021, SONY partnered with Latimer to bring his unique blend of science and magic to online and to PBS to assist with distance learning. Impossible Science’s growth has been exponential ever since, garnering over a hundred million views and multiple streaming awards as an educational series.
Pokémon GO Datamine Reveals Explorer Gadget, a Virtual Auto-Catching Item
Trainers, a new in-game item that could fundamentally change we Trainers play Pokémon GO has been spotted in the game’s code. According to a recent datamine by the ever-watching PokeMiners, Scopely is working on an item called the Explorer Gadget, which appears to replicate the functionality of physical auto-catching devices like the GO Plus and […]
Planned Parenthood, groups launch campaign against transgender ballot measures in Colorado
Planned Parenthood and other groups have launched a coalition to oppose two ballot measures that would ban transgender surgeries among children and require student athletes to only join sports teams that correspond to their biological sex. The two measures will appear in this year’s November ballot, setting the stage for a statewide debate over sports, […]
Pro-Iranian group claims credit for hack of FBI director's personal account
The group Handala posted online what appear to be years-old photographs of Patel, along with a work resume and other personal documents
Apple Now Sending Critical Security Alerts to iPhones Running iOS 17 and Earlier
Apple has begun pushing Lock Screen notifications to iPhones and iPads running older versions of iOS and iPadOS, warning users of active web-based attacks. The alerts, which appear as a "Critical Software" notification from the Settings app, warn that Apple "is aware of attacks targeting out-of-date iOS software, including the version on your iPhone," and urge users to install a critical update to protect their device.
Red Wings Call Up Postava on Emergency Basis
The post Red Wings Call Up Postava on Emergency Basis appeared first on Detroit Hockey Now. Cam Talbot’s injury prompted the Detroit Red Wings to call up Grand Rapids Griffins goalie Michael Postava on an emergency […] The post Red Wings Call Up Postava on Emergency Basis appeared first on Detroit Hockey Now.
Citrus County Chamber calls out 'optics' of Jeff Kottkamp's appearance with CFO
'Public statements suggesting mismanagement, without full context, risk undermining community trust'
Judge rejects Green Party candidate’s bid to appear on California governor ballots
California Green Party candidate Butch Ware failed to submit correct tax returns in time to appear on the June ballot for governor, a judge ruled Thursday.
Zendaya Reveals Why She’ll ‘Disappear’ For A 'Little Bit' After 2026
The actor made the confession amid rumors she secretly tied the knot with her fiancé, Tom Holland.
Trump's signature to appear on future currency, Treasury announces
The move breaks with longstanding precedent. For more than a century, US banknotes carried the signatures of Treasury officials, not the president.
Trump’s signature will soon appear on US dollar bills, a first for a sitting president
US paper currency will soon feature President Donald Trump’s signature going forward, the US Treasury Department announced Thursday, the latest of the president’s efforts to leave his mark across the federal government.
Trump’s Signature to Appear on U.S. Paper Currency
The Treasury Department said he was set to be the first sitting president to have his name on American money
Rep. Sheila Cherfilus-McCormick appears before House Ethics for rare public hearing
Democratic Rep. Sheila Cherfilus-McCormick appeared before the House Ethics Committee on Thursday in a rare public hearing to face allegations she stole millions in federal disaster funds and used it to bolster her 2021 campaign.
To assess AI in health care, study the human-machine team
AI health care tools appear to have a reliability problem, and experts suggest a new way of evaluating them.
Artificial Detective: Breaking Down the Gameplay Behind This Incredible Xbox Partner Preview Reveal
Artificial Detective puts you on the case of solving humanity’s disappearance. We spoke to its creators on how they're blending hacking, stealth, and companion abilities in this upcoming decopunk action-adventure.
Weekend Entertainment
Alex Rodriguez, a 14-time Major League Baseball All-Star, will make an appearance as part of YSU’s Thomas Colloquium lecture series.
Zendaya plans to ‘disappear’ for a 'little bit' after releasing 4 movies in 2026: ‘I’m going into hiding’
Once her jam-packed 2026 ends, Zendaya is ready to give audiences a break from her on the big screen. She stars in 'Spider-Man: Brand New Day' and 'Dune 3,' among others.
Savannah Guthrie fears her mom was targeted because of her
In her first interview since her mother's disappearance, Savannah Guthrie discussed her fears that her fame had something to do with the case.
Ahead of Atlanta visit, Cory Booker casts Georgia as key political battleground
U.S. Sen. Cory Booker heads to Atlanta on Friday to appear alongside U.S. Sen. Raphael Warnock at the First Baptist Church of Decatur.
Exclusive: Kamala Harris to appear at Democratic events through the South in April
As speculation continues about what Kamala Harris will do next, she has at least the first part of an answer: a swing through four Southern state Democratic Party events in April.
Orlov Offers Winning Wisdom Amidst Sharks’ Losing Streak (+)
ST. LOUIS — Dmitry Orlov has been an unappreciated leader in the San Jose Sharks’ surprising season. The veteran defenseman is also one of just four Sharks players who have won a Stanley Cup. Orlov hoisted the Cup in 2018 with the Washington Capitals. “It’s not easy. It’s a mind-set,” he said. “If you want […] The post Orlov Offers Winning Wisdom Amidst Sharks’ Losing Streak (+) appeared first on San Jose Hockey Now.
Why Vince Vaughn thinks late-night TV 'stopped being funny'
Vince Vaughn shared his hot take on the state of late-night television during an appearance on Theo Von's "This Past Weekend" podcast.
States Brace for a Potential Supreme Court Ban on Late-Arriving Ballots
The court’s conservatives appear skeptical of laws allowing mail ballots to arrive after Election Day. A decision could come as late as June, potentially scrambling midterm elections.
Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Amazon Prime Day 'Big Spring Sale' Introduces Major Discounts on AirPods, iPads, AirTag, and Much More
Amazon this week is hosting a "Big Spring Sale," which includes deals and offers on everything from Apple devices to clothes, kitchen electronics, furniture, and much more. The new event is set to run through March 31, so you'll have a few days of discounts to shop, with new markdowns appearing every day. Note: MacRumors is an affiliate partner with some of these vendors. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
macOS Tahoe 26.4 Adds Slow Charger Indicator for MacBooks
macOS Tahoe 26.4 includes a new slow charger indicator that tells MacBook users when their charging setup isn't delivering full power. As described in an updated Apple support document, a "Slow Charger" label now appears in orange text in the battery status menu and above the Battery Level graph in Battery settings. The indicator is accompanied by an info button for more details.
Fox Sports Host weighs in on the Chiefs acquiring QB Justin Fields
During a recent media appearance, Fox Sports Host Nick Wright weighed in on the Kansas City Chiefs acquiring quarterback Justin Fields | @EdEastonJr
Long lines persist at some U.S. airports despite ICE arrival
The Trump administration’s deployment of ICE officers to more than a dozen U.S. airports appeared to have a limited effect on reducing security lines.
Defiant Democratic candidates in California governors race dig in
State Democratic Party leaders, including Gov. Gavin Newsom, appear unwilling to force lower-polling Democrats out of the race.
iOS 27 Siri Overhaul: Standalone App, New Design, Dynamic Island Integration and Ask Siri Button
Apple is testing a standalone Siri chatbot app for iOS 27, reports Bloomberg's Mark Gurman. Apple plans to debut a chatbot version of Siri that will compete with Claude and ChatGPT, and the new Siri could be accessible through a dedicated app. Gurman previously said that Apple was not going to develop a standalone Siri app, but it appears plans have changed.
Georgia: Opposition politician Elene Khoshtaria given politically motivated prison sentence for graffiti
In Elene Khoshtaria’s case, the severity of the punishment appears related not to material damage, but to her political opinions and the symbolic damage she has inflicted on the ruling party
Exclusive: Samsung Galaxy Z Fold 8 Official CAD Renders & Rumors
This is the Samsung Galaxy Z Fold 8. After a pretty huge upgrade last year, for the Galaxy Z Fold 7, Samsung doesn't appear to be making any massive
Scientists Sequenced the DNA of the ‘Last Neanderthal’—and It Alters Human History
Discover new clues about how our ancient relatives disappeared from time.
Switch 2 demand appears to be flagging as Nintendo reportedly lowers production
Nintendo's Switch 2 got off to a roaring start but demand has started to sag, particularly in the US. Where are the big games to reverse this?
BIW strike comes weeks after visit by U.S. Defense Secretary Pete Hegseth
The strike arrives several weeks after a morale-boosting appearance in which U.S. Defense Secretary Pete Hegseth touted the need to boost defense manufacturing.
The Supreme Court’s conservatives could significantly alter the 2026 election
The Supreme Court on Monday appeared ready to limit mail-in ballots, a move that would reinforce the justices’ pattern of shrinking voter protections and that has, at bottom, favored Republican interests and the Trump administration.
The View: Politicians Disappear From ABC Show After Trump FCC Threat
The ABC panel show hasn't had any political guests on since the FCC announced it was investigating it. That changed today as the network fights the feds ahead of the midterms.
Takeaways from arguments in the Supreme Court case that could end grace periods for mail-in ballots
The Supreme Court’s conservative majority appeared dubious of state laws that allow the counting of mail ballots that arrive at election offices after Election Day as justices heard oral arguments in a challenge to Mississippi’s five-day grace period for mail ballots.
The Supreme Court seems alarmingly willing to trash thousands of ballots
At least four justices appear to be on board with a frivolous lawsuit attacking voting by mail.
SCOTUS conservatives signal readiness to curb late-arriving mail ballots
Conservative Supreme Court justices appeared skeptical during oral arguments of allowing states to continue counting late-arriving mail-in ballots. A decision is expected in June.
iPhone Air Said to Be Roughly Twice as Popular as iPhone 16 Plus
While it certainly has its critics, the iPhone Air appears to have validated Apple's decision to retire the iPhone Plus, if new results from an independent analysis are anything to go by. Crowdsourced Speedtest data published by Ookla suggests the iPhone Air captured 6.8 percent of iPhone 17 generation samples in the U.S. during the fourth quarter of 2025, up from the 2.9 percent share the iPhone 16 Plus managed in the same launch window a year earlier.
While Intel Skipped Core Ultra 9 290K Plus, It Appeared At Geekbench With A Staggering 17% Higher Single And Multi-Core Score Than Ultra 9 285K
Intel's Core Ultra 9 290K Plus scores 3747 single-core and 26117 multi-core in Geekbench, showing a 17% performance boost over the 285K.
Revolutionary Submarine Mysteriously Disappears Without a Trace – Scientists Are Now Preparing for a Bold Return
A pioneering robotic submarine that explored beneath Antarctica’s glaciers has been lost, but its discoveries are reshaping our understanding of ice melt as a more advanced successor is prepared to continue the mission.
Blue Jays extend manager John Schneider, GM Ross Atkins following World Series appearance
The Blue Jays are locking up two architects of the team's World Series run.
A promising fatty liver treatment may raise cancer risk
A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that without this enzyme, liver cells grow abnormally large and accumulate genetic damage, leading to inflammation, scarring, and eventually tumors, especially with age. While inhibiting Caspase-2 may offer short-term benefits, such as reducing fatty liver disease, the long-term consequences appear dangerous.
Carrie Anne Fleming, 'Supernatural' and 'iZombie' actress, dies at 51
Carrie Anne Fleming, who appeared on 3 episodes of 'Supernatural' as Bobby's wife Karen, has died. She was 51.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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Frank Vizetelly’s illustration titled “Night Amusements in the Confederate Camp” appeared in the Illustrated London News on January 10, 1863. It was one among a number of wartime scenes that Vizetelly captured for the newspaper. Subscribe Following the war, the illustration appeared in a number of books, including John O. Casler’s Four Years in the Stonewall Brigade (1893) and Campfires of the Confederacy (1898) by Ben La Bree. The scene depicts a Confederate camp at night with an enslaved man, most likely a camp servant, performing a dance around a fire with the music provided by a soldier playing a banjo. Another enslaved man looks on at the right. Vizetelly likely witnessed the scene—one that would have been common throughout the war. It’s a wonderful example of the way in which Confederates—slaveowners and nonslaveowners alike—experienced the presence of slave labor in the army. Vizetelly was deeply sympathetic to the Confederate cause. His depiction of the enslaved man as more than happy to entertain the very people who were fighting to keep him enslaved was precisely the kind of image designed to reassure a British audience that slavery was benign, and by implication, that Britain need not feel morally troubled about recognizing or supporting the Confederacy. Share Just as importantly, the sight of a dancing slave reassured Confederates themselves that the institution of slavery remained secure even after President Lincoln signed the Emancipation Proclamation. I’ve come across this illustration many times before and I plan on using it in my next book project on the role of enslaved labor in the Confederate army during the Gettysburg Campaign, but this is not the reason I am sharing it with you today. It has to do with where I recently found it, which came as a complete surprise and is incredibly revealing. Let’s take a look.
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New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. 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On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
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AI-generated follow-up questions and answers
Appearing just below the summary bullets, these AI-generated follow-up questions and answers let readers quickly explore further context and angles.
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