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America split from monarchy 250 years ago. Trump's presidency is testing how far it's come
America is getting ready to celebrate the 250th anniversary since it split from Britain's monarchy and embarked on its experiment in democracy.
The Politics of the Instagram Story
Drive yourself crazy for the low price of $3.99 a month!
Israel missing out on global life sciences recovery
IATI's annual report for 2025 portrays general stagnation in the Israeli industry. with one or two bright spots.
What is extra time in the World Cup knockout stage? Complete rules explained
When a match ends in a draw in the single-elimination phase of a soccer tournament, an additional 30 minutes of play are required
NH's Business: Projected nursing shortages
Fred Kocher sits down with Chuck Lloyd with the Community College System of NH and Kimberly Perrotta with Manchester Community College to talk about working to combat a projected nursing shortage.
Inside country legend Alan Jackson's triumphant finale concert
Country music legend Alan Jackson has ended his touring career.
📝 2026 World Cup, overnight round-up
Every morning, OneFootball will bring you a full recap of the night at the World Cup. The can't-miss story of the nightThat's it, the group stage of this World Cup is now officially over, and the hea...
4 Takeaways From A Dramatic Ending Between Austria And Algeria In The Group J Finale
In what was the most dramatic ending to a group-stage match at the 2026 FIFA World Cup, Austria and Algeria played to a wild 3-3 draw at Kansas City Stadium on Saturday night.
Messi Becomes First Player To Score In Seven Straight World Cup Matches
Lionel Messi has become the first player to score in seven consecutive World Cup games while extending his all-time scoring record with his 19th goal in Argentina’s group stage finale against Jordan.
LGBTQ+ Pride parades set for Sunday in NYC and San Francisco
Pride Month celebrations are peaking with big parades in New York, San Francisco and some other cities on Sunday.
Severe storms cause disruptions to businesses, events in Nashville
From weather delays to power outages, severe storms moving through Nashville caused several disruptions.
Caminero to the moon: Rays 4, D-Backs 2
Before you could grab your hot dog, popcorn, and preferred pilsner beverage, the Diamondbacks took a 1-0 lead on a Geraldo Perdomo double, Corbin Carroll single, and a whiff of a tag from catcher Hunter Feduccia. In the bottom half of the first, Junior Caminero hit a thunderous, sky-scraping blast for his sixth homer in […]
Esports means business for new generation of fans
Valhallan, a youth esports training organization, hosted a grand reopening of its second Long Island storefront in Wantagh on Saturday.
BET Awards: Druski to make history as youngest host as show honors Lauryn Hill and Teyana Taylor
Druski will make history as the youngest host of the BET Awards on Sunday.
BET Awards: Druski to make history as youngest host as show honors Lauryn Hill and Teyana Taylor
Druski will make history as the youngest host of the BET Awards on Sunday.
FIFA World Cup: England is coming to Atlanta
As the Group Stage concludes, Atlanta has more world-class soccer and excitement to look forward to.
San Antonio Pride festival celebrates LGBTQ+ community, raises money for local nonprofits
Thousands of people were expected at Crockett Park on Saturday for the Pride Bigger Than Texas Festival, an eight-hour celebration of LGBTQ+ history, resilience and community support.
Scotland's elimination from World Cup confirmed
Scotland are out of the 2026 World Cup as they are unable to finish the group stage as one of the eight best third-placed teams.
ABC7 reporter goes viral after declaring she doesn’t want to know anything about Bosnia
An ABC7 Los Angeles reporter has gone viral ahead of the United States’ World Cup round of 32 matchup with Bosnia and Herzegovina next Wednesday in Santa Clara, and not for the right reasons Reporter Abigail Velez, wrapping a live shot from Long Beach following the UMSNT’s group-stage loss to Türkiye, announced proudly that she…
Open 2026 World Cup Watch Thread: Day 17
It’s the final day of the group stage, and there’s another six games on the schedule.
Citing construction, downtown Noblesville business will close
The Velvet Plum Vintage & Consignment, a home decor and furniture consignment shop at 894 Logan St. in Noblesville, has announced it will close July 15, citing Embrace Downtown construction as the driving factor. The Embrace Downtown project began earlier this year to provide infrastructure a
Citing construction, downtown Noblesville business will close
The Velvet Plum Vintage & Consignment, a home decor and furniture consignment shop at 894 Logan St. in Noblesville, has announced it will close July 15, citing Embrace Downtown construction as the driving factor. The Embrace Downtown project began earlier this year to provide infrastructure a
Beloved Brookline restaurant closes after over 60 years in business
A well-known Brookline restaurant announced on Instagram that it officially closed for good after over 60 years in business.
A Clover Health Director Sold Over 67,000 Company Shares. Here's a Closer Look at the Transaction.
This healthcare technology firm, focused on Medicare Advantage plans, reported a notable insider sale amid muted stock performance.
WWE Files To Trademark 'Bakusai' - Fightful | WWE News, AEW News, Pro Wrestling Backstage News
On June 26, 2026, WWE filed a new trademark for 'Bakusai.' Fans can click the article to read more about this.
How to Watch the World Cup Today: Schedule, Times, TV, Streaming for Argentina, England, Portugal, More
Argentina, England, Portugal and more close out group stage play today at the 2026 FIFA World Cup. All 6 matches air on FOX and FS1.
Saturday Sports: The World Cup enters knockout stage; Serena returns to Wimbledon
NPR's Scott Simon and sportswriter Howard Bryant have a World Cup knockout stage preview and discuss Serena Williams' return to Wimbledon.
Country Star Releases New Album for the First Time in Nearly Three Years
Cody Johnson returns with his first studio album in nearly three years, featuring 16 tracks and deeply personal stories inspired by his Texas roots.
Fallout from USMNT loss to Turkey and previewing the Mbappe-Haaland clash
On today’s show, we look back at the United States’ final group stage match against Turkey and evaluate their readiness for the Round of 32. Manchester City insider Sam Lee joins us to preview the tournament’s first true superstar heavyweight clash as Kylian Mbappe and France square off against Erling Haaland and Norway in a battle for Group I supremacy. Plus, The Athletic’s Jay Harris is back in the studio to break down the latest bracketology, advancement percentages, and qualification permutations for Groups G, H, and I using The Athletic’s World Cup Tracker.
Colombia vs. Portugal scenarios, explained: How final Group K game will impact 2026 World Cup bracket
Colombia and Portugal clash in one of the most intriguing games in the final round of group-stage matches at the World Cup.
That advancing to the knockout stage feeling 🇨🇻
That advancing to the knockout stage feeling 🇨🇻
States seek to lower drug prices by targeting the companies that manage them for health plans
Legislators across the U.S. are trying to lower prescription costs by reining in big companies that handle drug coverage for health insurers.
Baylor teen health clinics provide free medical care, mental health services
According to the latest U.S. Census data, Texas leads the nation in the number of uninsured residents.
Muslera blunders, sets unwanted Cup record, and socials pounce
In Guadalajara, Mexico, Spain is leading Uruguay 1-0 this Friday (26), in the third round of the group stage of the 2026 FIFA World Cup.La Celeste’s partial defeat, in fact, is securing Cape Verde��...
Trump news at a glance: president tests out a new ‘red scare’ ahead of midterms
Republican strategists believe rise of Mamdani could present opportunity to tag Democrats with most extreme views of the left – key US politics stories from Friday 26 June
Return of the Rushing King, Alvin Kamara
Kamara is one of the most beloved Saints players, but what will this season be for him and the fans
Caitlin Clark Fans Staging Boycott For Saturday's Fever Game
This Saturday's showdown between the Indiana Fever and Los Angeles Sparks has unfortunately lost some of its appeal due to Caitlin Clark's latest injury. Clark suffered a back injury during Wednesday's loss to the Phoenix Mercury. To make matters worse, she was on the receiving end of a cheap shot ...
We almost had a smartphone in the 90s. Why did it fail?
In the early 90’s, a company called General Magic began working on a portable device that would allow people to check email, make phone calls, even play games. It was basically a smartphone. But it never caught on.On today’s show, a theory about why this device failed. General Magic had generous investors, world-class talent and creative freedom. But is it possible what they needed was constraints?Support:Planet Money+Read: Our book: Planet Money: A Guide to the Economic Forces That Shape Your Life Our weekly longform Planet Money newsletterOur weekly Indicator round-up newsletterFollow: InstagramTikTokYouTubeFacebookThis episode was hosted by Erika Beras and Emma Peaslee. It was produced by Emma Peaslee with help from Sam Yellowhorse Kesler and James Sneed. It was edited by Marianne McCune and fact-checked by Charlotte Isidore. It was engineered by Jimmy Keeley with help from Cena Loffredo. Alex Goldmark is Planet Money’s executive producer.
The Venezuela Earthquakes Hit a Health System Already in Crisis
Firefighters are using cellphone lights because of a flashlight shortage, and an overwhelmed hospital in the disaster zone is operating without running water, one doctor said.
Iran's Pride Match is about visibility, not politics
Iran’s World Cup match against Egypt has become a test not only of FIFA’s approach to inclusion but also of whether LGBTQ+ Iranians can claim visibility on one of the world’s biggest sporting stages.
Moderna highlights expanding mRNA platform at Science Day
Moderna's Horizon programme contains a variety of mRNA assets in varying stages of development, including a preclinical in vivo candidate.
From The Sports Desk: The U.S. lost, but also saw return of star Christian Pulisic
The Americans may have lost their final group stage. But Pulisic, who had been nursing a calf injury, returned to action. He’s back just in time for the start of the knockout round.
TLC stage musical “CrazySexyCool” reveals exclusive first look images of T-Boz, Left Eye, and Chilli
The 1990s girl group gets their story told on stage.
Music Legend Axes Shows After Onstage Health Scare
Lionel Richie was hospitalized on the opening night of his tour with Earth, Wind & Fire after feeling dizzy on-stage.
How Brad Pitt appears in “Jackass: Best and Last”: 'It was wild,' says Steve-O
The "Inglourious Basterds" actor shows up in the latest "Jackass" movie via archival footage from 2001.
Newsom urges a national 'billionaires' tax' while fighting one in California
California Gov. Gavin Newsom is calling for a national “billionaires' tax” and suggests the U.S. government should own a stake in AI companies.
NASA's canceled Artemis hardware contracts reached $5.9 billion, audit finds
NASA was on track to pay nearly half a billion dollars for a stage adapter. A stage adapter should not cost half a billion dollars.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Remembering Victory Stadium: How Roanoke’s lost landmark changed sports and civil rights
It’s been 20 years since Victory Stadium was demolished, but the memories and legacy remain alive in Roanoke.
Smart voices in business react to Apple and Xbox price hikes
After Apple and Microsoft's Xbox raised prices due to a shortage of memory chips, tech observers are not optimistic about future prices.
World Cup 2026: USMNT stunned by Türkiye in stoppage time, losing perfect group stage run
Hollywood gets into the microdrama race as mobile-first storytelling draws stars and major studios
Mobile-first serialized storytelling is rapidly becoming one of entertainment's fastest-growing businesses.
4 Takeaways From USA's Last-Second World Cup Loss To Türkiye
So much for a perfect group stage. But the USA can now turn its attention toward the knockout stages.
UFC Baku early weigh ins results
Ultimate Fighting Championship (UFC) will stage its early and official weigh ins at 9 a.m. local time for this weekend’s UFC Baku mixed martial arts (MMA) event on Paramount+. Unfortunately for stateside fight fans, Baku is eight hours ahead of Eastern Standard Time, so most of us will be asleep by the time the first […]
Twin City Entertainment collaboration to host the Carol Burrnett Show in West Monroe June 27th
WEST MONROE, La. (KTVE/KARD) — Residents in the West Monroe area will have the chance to enjoy a night of laughter later this week as a live stage production inspired by The Carol Burnett Sho…
Clinicians are making more money despite stagnant reimbursement. Guess how?
Compensation for healthcare providers rose some 4.3% in 2025. The sobering news is that the gain owes more to heavier daily workloads than to bigger per-patient billings.
‘Turf Tank’ robot elevates Oregon sports fields
The Oregon Youth Soccer Association is taking advantage of some new technology to keep its fields game day ready.
World Cup 2026: Christian Pulisic won't start for USMNT's group stage finale against Türkiye
Lionel Richie postpones concerts after falling ill during tour opener
Lionel Richie is pausing his return to the stage after abruptly falling ill during the opening of his new tour.
All the songs on Ariana Grande's Eternal Sunshine Tour
OAKLAND, Calif. – It's been six years since Ariana Grande’s last tour, and her yellow brick road has led her back to the stage.
Monkey Business: Wild rhesus macaque spotted at Mount Dora hotel
A wild rhesus macaque was spotted at the historic Lakeside Inn in Mount Dora, Florida, spending about 45 minutes roaming the property and attracting attention from guests and staff. The hotel and local businesses responded with humorous, monkey-themed social media content, engaging the community. Wildlife officials cautioned the public not to approach or feed wild monkeys due to potential health risks and encouraged reporting sightings to authorities. The monkey has not returned to the hotel but has been seen elsewhere in downtown Mount Dora.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Ormond Beach businesses push drivers to slow down on Granada Boulevard
Downtown Ormond Beach businesses are taking matters into their own hands after drivers continue to ignore a reduced speed limit on Granada Boulevard — nearly a year after the change took effect.
These Churches Are Putting Family Before Politics
Close to 70 percent of Black children in America are born to unmarried parents. Nearly half live with a single mother. Both figures are significantly higher than the national average and reflect the steep decline in marriage among African Americans since the 1960s.
This Week in Jacksonville: Business Edition - Tim Cost reflects on 14 years leading Jacksonville University
As Jacksonville University prepares to welcome new leadership, outgoing President Tim Cost says his focus remains on the institution’s future rather than his own legacy.
SBA’s Proposed Update to the 8(a) Business Development Program: A New Approach to Social Disadvantage
On June 11, 2026, the Small Business Administration (“SBA”) published a proposed rule that would fundamentally alter how individuals qualify as “socially
Steam Summer Sale 2026 is live
The great big sale event of the hot season has landed, the Steam Summer Sale 2026 is live now with masses of games featuring big discounts.
Lionel Richie takes ill, cuts opening concert of tour short
The Rock & Roll Hall of Famer, who is 77, told his 10,000 fans he was feeling dizzy but performed for nearly an hour before leaving the stage.
Xbox prices spike another $100 or more
Xbox blames the memory shortage for the price hike.
'Avengers: Endgame' rerelease confirms new title, footage, and end tag
'Avengers: Endgame' rerelease gets a new title and confirms fresh footage and a special end tag.
Lionel Richie reportedly hospitalized after medical incident forced concert to end early
Lionel Richie has reportedly been hospitalized after a medical incident on stage forced him to sit down to sing a song on the opening night of his tour with Earth, Wind & Fire.
Embodying the Moment: Paloma Elsesser On Beauty, Bodies and Business
The model and muse explained her supermodel origin story and her plans for her next act onstage at The Business of Beauty Global Forum.
Rush CEO to step down, take health equity mission to national stage
Dr. Omar Lateef said he is handing off a health system at the top of its game and expects healthcare leaders from around the nation will be clamoring to fill the role.
Windcrest welcomes new restaurants, businesses as city works to close revenue gap left by Rackspace
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How should European scientists respond to the US AI kill switch?
Earlier in June, Europe’s worst fears of technological dependence were confirmed when the White House ordered the AI firm Anthropic to stop non-US citizens using its leading models. This kill-switch moment crystalised anxieties in Brussels that the continent, lagging the US on the creation of leading-edge AI models, is now a technological of vassal of Washington. The shock has specific implications for European scientists and universities. Some governments are now worried that with AI being integrated into labs, Donald Trump now has his finger hovering over an off switch for European science. “Having restrictions on this tool, it can have an impact on our own research,” said France’s research minister, Philippe Baptiste, at the VivaTech conference in Paris on June 18.Baptiste, himself a former academic, said that colleagues in mathematics had recently warned him they were now cut off from leading-edge US models, risking their work. “This model is not available anymore now because of the US restriction, and for the first time this had an impact on mathematics,” a field where large language models (LLMs) are making a significant contribution, said Baptiste. So, should European scientists avoid relying on US models in the future? Or would this be a self-harming overreaction? And how is AI being used in science, anyway? What happened?On June 12, it emerged that Washington, citing cybersecurity concerns, had ordered Anthropic to stop non-US citizens using two models: Claude Mythos 5, and Claude Fable 5, a version of Mythos but with guardrails to prevent abuse. Anthropic said Washington’s concerns were overblown. But forced to follow the order, yet with no way to check who was using the models, the company suddenly shut down access for everyone, US citizens included. There’s still no agreement on how to restore broad access. But last week, Bloomberg reported that select US companies, and the US government, still had access to Mythos despite the ban, but the EU’s cybersecurity agency Enisa had been shut out. Class division of researchersIn the longer term, access outside the US should be restored, said Marcel Salathé, co-director of the AI centre at the Federal Polytechnic School of Lausanne (EPFL), because a permanent restriction would be financially ruinous to US AI firms. “Even Trump will eventually budge to economic pressure,” he said.However, US AI firms might end up operating rather like banks, doing due diligence on users of their leading-edge AI models, he went on.European scientists are unlikely to fall foul of such checks, he said. But having a Chinese postgraduate in their lab, or doing a type of research the US disapproved of, could potentially result in access being denied. “It will create a sort of class division of researchers,” he said. More than frontier modelsHowever, successfully deploying AI in science is about far more than just having access to leading LLMs such as Mythos.Instead, many science-specific tools, most famously Alphafold, which predicts protein folding structures, require “far less” computing power to train than frontier models, well within the capabilities of European supercomputers, according to a recent analysis by the Arq Foundation, a Brussel-based AI think tank. Instead, tools such as Alphafold are possible because certain fields, like protein folding, weather prediction or astronomy, have large, clean, standardised datasets that can be used to train predictive models. Rather than compute, “data is the central constraint for AI for science,” the report says. For example, a less powerful physics model trained on CERN’s data “will be more valuable than the best model without certain data,” said Bengüsu Özcan, author of the report. European advantage?Europe could therefore steal a march by using its scientific data and infrastructure to create models US digital giants cannot. “They might actually match or go even beyond what these big [US] companies are doing,” said Özcan.Indeed, some European start-ups hope to create automated testing labs to create the kind of standardised data that could speed up the discovery of new materials. Materials scientists say there’s currently too little data to train models. AI scientistsHowever, even if the bottleneck for AI in science is often data, rather than compute, being at the mercy of the US for LLM access could still become a problem for European scientists. A new class of “AI scientists” based on leading LLMs is also emerging, Özcan’s report says.Unlike domain-specific tools like Alphafold, these try to automate day-to-day scientific work, by providing an overarching tool that coordinates specific models to synthesise existing literature, generate hypotheses or run analysis of data. The problem for Europe, however, is that these tools are sometimes based on US leading models. Google Deepmind’s AI Co-Scientist, for example, is built on Google’s Gemini LLM. Systematic failureThese scientific automation tools are still in their early stages, and still exhibit “systematic failures on scientific tasks,” Özcan’s report says. One of the problems is that the messy, day-to-day process of scientific discovery is largely not documented, meaning LLMs don’t have a good source of data to learn how scientists actually work. Meanwhile, some tasks, such as literature synthesis, don’t typically require access to leading edge models.However, the performance of AI scientific assistants could improve as companies such as Google pour resources into developing them. Rely on US“Unfortunately, for scientific assistants, there is not much we can do right now except rely on US frontier AI,” said Antoine Bosselut, a natural language processing expert based at EPFL. Chinese-built open models, which can run on local computers, lessening the risk of a shutdown, are touted as one alternative to US dependence. There’s also Mistral, once seen as Europe’s main AI hope, but the Paris-based company has seen its recent models fall behind in performance. But the Chinese alternatives are generally not as capable as US frontier AI models, said Bosselut, unless paired with fiddly, custom tools that allows them to act as independent agents. “Most scientists do not have the time,” he said. Don’t jump ship yetAlthough the kill switch moment is seen a warning shot for European scientists, it doesn’t mean labs should abandon US AI tools immediately. “I do not think the right response is simply to abandon US-based models and systems under the banner of sovereignty or independence,” said Mattias Björnmalm, secretary general of the Cesaer university association. “That would be an overreaction.”Related articlesEuropean sovereignty in AI requires ‘ugly trade-offs,’ say experts Robotic lab start-up makes case for €500M EU-funded materials testing facilityAI in science: is it useful? Instead, European researchers need to ask themselves whether they’re becoming dependent on technology that could be turned off in Washington, said Özcan. “They might not see this today, but they should really start asking this question,” she said. European researchers need a plan B, said Salathé. “I would recommend to every researcher, very proactively explore alternatives.”Own toolsIn addition, Björnmalm and others want European research institutions to develop their own scientific AI tools.Instead of signing AI deals with US digital giants, European universities should be using this money to create their own models, which may end up being superior for research, said Sabine Leonelli, an expert on the use of AI in science at the Technical University of Munich. “Universities in Europe seem to be happy to sign commercial contracts with US companies on the assumption [their AI tools] are better,” she said. But US frontier LLMs are typically opaque, and have been developed without independent scientific input, she said. “This is not good enough for science.”Last year, Swiss researchers released Apertus, an LLM designed to be completely transparent, from its development methods to its training data. The idea is that this makes scientific tools built on top of the model far more reproducible than with closed, commercial alternatives.“Europe needs more of this: serious capacity-building that gives researchers, universities and companies credible options,” said Björnmalm.
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