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New nonprofit health center opening in Philadelphia, with a goal to help the formerly incarcerated
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Mar 27 • 9:50 AM EDT • Health • cbsnews.com
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Does Saka Deserve More Empathy?

First of all, I should clarify that I have always viewed Bukayo Saka as overrated. A good player, but not world-class, as some Gooners would have you believe. Certainly, he is young enough to develop ...

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Mar 27 • 9:30 AM EDT • Sports • sports.yahoo.com
“Night and day”: Adventuring through childhood with newfound immune systems

This article discusses the significant impact of an accelerated FDA-approved gene therapy on children with severe leukocyte adhesion deficiency-I. Families share how their lives have transformed from chronic hospital visits to thriving, healthy lifestyles following the treatment at UCLA.

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Mar 27 • 8:00 AM EDT • Health • uclahealth.org
As Trump feels pressure to end war, allies fear what Iran may do next

Iran has demonstrated it can inflict significant damage on the world’s economy, even while outgunned. That creates a dilemma for President Trump.

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Mar 27 • 5:00 AM EDT • Politics • washingtonpost.com
Long Island Science Center faces renewed eminent domain threat from Riverhead

Town board members, exasperated at the lack of progress on renovations to the science center's Main Street facility, said they would give its leaders one more chance to make their pitch.

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Mar 27 • 5:00 AM EDT • Science • newsday.com
Anderson Cooper reacts to Trump shaming those with dyslexia
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Mar 26 • 10:47 PM EDT • Politics • cnn.com
Where is money from Sonoma County’s voter-approved tax for mental health, drug addiction, homeless services going?

Sonoma County’s Measure O, which funds mental health, drug abuse and homeless services, generated $33 million in fiscal year 2024-25, according to latest annual report.

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Mar 26 • 8:00 PM EDT • Health • pressdemocrat.com
Amy Mistler Celebrated as Top Business Advisor in St. Louis

Spencer Fane is pleased to announce attorney and St. Louis Office Managing Partner Amy Mistler as a 2026 St. Louis Small Business Monthly Top Business

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Mar 26 • 3:11 PM EDT • Business • spencerfane.com
Trump says it’s up to Iran to convince US to end the war
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Mar 26 • 1:46 PM EDT • Politics • cnn.com
2025 American Association for the Advancement of Science (AAAS) Fellow

Department Chair, Professor Alexander Spokoyny has been selected as a 2025 Fellow of the American Association for the Advancement of Science (AAAS) in recognition of his distinguished contributions in main group and organometallic chemistry and academic community engagement and leadership. AAAS is the world’s largest general-scientific society and publisher of the journal Science. Spokoyny is among the 449 scientists, engineers, and innovators spanning 24 scientific disciplines who are being recognized for their scientifically and socially distinguished achievements. Four of the new fellows are UCLA faculty members. The new Fellows will be celebrated in Washington, D.C., in late May 2026. Read more about the new AAAS Fellows here. AAAS Fellows in the UCLA Department of Chemistry & Biochemistry are Professors Kendall Houk (1988), Paul Weiss (1999), Richard Kaner (2000), David Eisenberg and Todd Yeates (2001), Juli Feigon (2002), Miguel Garcia-Garibay and Steven Clarke (2007), Heather Maynard, Carla Koehler, Xiangfeng Duan and Neil Garg (2018), Paula Diaconescu and Thomas Mason (2019), Joseph Loo (2021), and Yi Tang (2022). Penny Jennings, UCLA Department of Chemistry & Biochemistry, penjen@g.ucla.edu.

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Mar 26 • 11:05 AM EDT • Science • chemistry.ucla.edu
Women’s Hockey viewership sees major boost after Olympic success
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Mar 26 • 10:26 AM EDT • Sports • cnn.com
WhatsApp can now draft AI-generated responses based on your conversations

The Meta-owned messaging platform is also launching a way to free up space, the ability to touch up photos with Meta AI, and more.

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Mar 26 • 9:00 AM EDT • Technology • techcrunch.com
Mike Pence To Speak At UChicago’s Institute Of Politics In April

Pence will participate in a student-moderated panel and is expected to speak about the role of the executive branch, populism and more.

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Mar 26 • 8:10 AM EDT • Politics • blockclubchicago.org
Patrons celebrates Science Central’s planetarium grand opening

Science Central celebrated the grand opening of its planetarium on Wednesday: a project years in the making.

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Mar 25 • 6:15 PM EDT • Science • 21alivenews.com
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High-stakes Senate race in Texas sees proliferation of AI-generated attack ads

Campaigns are beginning to use phony AI-generated images in television ads to sharpen their attacks and, critics say, mislead voters.

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Mar 25 • 5:00 PM EDT • Politics • spectrumlocalnews.com
Augmenting citizen science with computer vision for fish monitoring

Monitoring river herring migration is essential for conservation and fisheries management. Researchers have now demonstrated a method using video and computer vision to supplement traditional methods and volunteer-based programs.

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Mar 25 • 5:00 PM EDT • Science • news.mit.edu
READY, SET, IMPLEMENT! Lifelines in Crisis: Prioritizing Women’s, Children’s, and Adolescents’ Health in Humanitarian, Conflict and Climate-affected Settings

This dialogue is part of PMNCH’s Ready, Set, Influence series, bringing together policymakers, humanitarian leaders, donors, and grassroots experts. The webinar will focus on accelerating the implementation of health commitments within humanitarian affairs, specifically focusing on the need for integrated, rights-based health services that remain resilient in the face of conflict, disaster and climate events.

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Mar 25 • 11:13 AM EDT • Health • pmnch.who.int
Glyphosate: A story of science, risk, and nuance

In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe

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Mar 25 • 10:25 AM EDT • Science • yourlocalepidemiologist.substack.com
Cardinal Health (CAH) Emerged as a Key Contributor on Pharmaceutical Strength and Margin Expansion

Renaissance Investment Management, an investment management company, released its Q4 2025 “Large Cap Growth Strategy” investor letter. A copy of the letter can be downloaded here. The strategy faced a difficult fourth quarter of 2025, underperforming both the S&P 500, which gained 2.7%, and the Russell 1000 Growth Index as market leadership remained concentrated in […]

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Mar 25 • 7:42 AM EDT • Health • finance.yahoo.com
Pitch deck: StoReel startup raised $34M to build AI micro dramas

StoReel describes how it uses AI and a user-generated platform to make micro dramas at a fraction of the cost paid by established players.

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Mar 25 • 7:00 AM EDT • Business • businessinsider.com
Sports Illustrated Stadium to host fan events during FIFA World Cup

Sports Illustrated Stadium will host fan events — unaffiliated with the 2026 FIFA World Cup — during the world's largest sporting event.

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Mar 25 • 4:31 AM EDT • Sports • northjersey.com
Sonic Frontiers "Definitive Edition" Has Been Rated In Korea

Super Sonic news

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Mar 25 • 1:30 AM EDT • Technology • nintendolife.com
Sonic Frontiers Definitive Edition rated in Korea

The Game Rating and Administration Committee of Korea has rated the unannounced Sonic Frontiers Definitive Edition.

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Mar 25 • 1:23 AM EDT • Technology • gematsu.com
Fix the process before reauthorizing state PUC

What needs to be fixed before reauthorizing the Public Utilities Commission? The answer is simple: the process. The last time the commission was reauthorized in 2021, lawmakers expanded its role in meaningful ways — particularly as Colorado accelerated its clean energy transition. The PUC was asked to do more, to carry more and to implement […]

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Mar 25 • 12:47 AM EDT • Politics • coloradopolitics.com
Epic flurry: How Trump’s words on Iran have yo-yoed over three weeks of war

He has dubiously claimed Iran posed an “imminent” threat to the US, months after declaring the US had “obliterated” Iran’s nuclear capabilities. He’s given a multitude of reasons for launching a war in the first place. He has declared victory scores of times, only to qualify those claims later on. Over the course of nearly a month, President Donald Trump has yo-yoed from demanding “unconditional surrender” to teasing a possible detente.

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Mar 25 • 12:00 AM EDT • Politics • cnn.com
8 new emojis arrive in Apple iOS 26.4 update for iPhone users

Along with eight new emojis, the latest Apple iPhone and iPad software update includes new Apple Music features such as AI-generated playlists.

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Mar 24 • 9:36 PM EDT • Technology • usatoday.com
Rochester Road construction has business owners livid, drivers frustrated
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Mar 24 • 7:54 PM EDT • Business • yahoo.com
'Sports Illustrated Swimsuit' Teases Sexy New Photo Shoots with Bethenny Frankel, Ilona Maher and More

'Sports Illustrated Swimsuit' teased its forthcoming 2026 issue featuring a mix of newcomers, as well as fan-favorite veterans.

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Mar 24 • 2:50 PM EDT • Sports • people.com
Marathon has sold 1.2M copies across Steam, PS5, and Xbox

Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]

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Mar 24 • 2:06 PM EDT • Technology • alineaanalytics.substack.com
Crowds fill 14th Annual St. Joseph’s Day Festival

The 14th Annual St. Joseph’s Day Festival hosted by the Ocean City (Md.) Sons & Daughters of Italy Lodge is in the books with another success, as demonstrated by the

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Mar 24 • 1:45 PM EDT • Entertainment • coastalpoint.com
Mouse study shows repeated cloning causes grave genetic mutations

1,206 cloned laboratory mice were generated by the scientists from a single female donor mouse from 2005 to 2025 in research conducted in Japan.

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Mar 24 • 12:22 PM EDT • Science • detroitnews.com
Apple takes aim at Google Workspace and Microsoft 365 with new hosted business email

The new Apple Business platform is expanding beyond device management. It now includes fully integrated email, calendar, and directory services for business domain.

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Mar 24 • 11:00 AM EDT • Technology • 9to5mac.com
Johannes Høsflot Klæbo on becoming the greatest Winter Olympian
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Mar 24 • 9:30 AM EDT • Sports • cnn.com
Alliant Private Client Strengthens Entertainment Practice with Addition of Michelle Quintero

IRVINE, Calif., March 24, 2026--Michelle Quintero has joined Alliant Insurance Services as Executive Vice President with Alliant Private Client. Based on the West Coast and recognized by Risk & Insurance® as a 2026 Entertainment, Hospitality & Gaming Power Broker®, Quintero brings more than 25 years of technical acumen and delivers tailored solutions to high-profile and celebrated individuals in music, film, and live events.

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Mar 24 • 8:05 AM EDT • Entertainment • finance.yahoo.com
Scientists found a rhino in the Arctic and it changes everything

Scientists have uncovered a new species of rhinoceros in the Canadian High Arctic, revealing that rhinos once lived far farther north than expected. The fossil, dating back 23 million years, is unusually complete and has helped reshape ideas about how these animals migrated between continents. Evidence suggests rhinos crossed from Europe to North America more recently than scientists once thought.

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Mar 23 • 8:00 PM EDT • Science • sciencedaily.com
Segment: Financing Action on Extreme Heat and Maternal and Newborn Health: The Way Forward

The segment “Financing Action on Extreme Heat and Maternal and Newborn Health: The Way Forward” will examine how innovative and better-aligned financing approaches can respond to these growing risks. Discussions will highlight country experiences in mobilizing domestic resources, opportunities to unlock and scale climate finance, and the role of heat-smart innovations in building resilient health systems. Particular attention will be given to low- and middle-income countries, where exposure and vulnerability remain highest, and where integrated solutions can deliver the greatest impact.

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Mar 23 • 8:00 PM EDT • Health • pmnch.who.int
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Scientists Connect “Time Crystals” to the Outside World in Groundbreaking Experiment

A newly demonstrated link between a time crystal and a mechanical system opens a door scientists once thought closed.

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Mar 23 • 4:46 PM EDT • Science • scitechdaily.com
'Players' of an MMORPG for AI Agents Spontaneously Generated Their Own Religion

SpaceMolt is a new destination for vaguely portentous word salad.

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Mar 23 • 4:35 PM EDT • Technology • gizmodo.com
Roger Bennett of the Men in Blazers discusses the agony and the ecstasy of watching a penalty shootout
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Mar 23 • 10:01 AM EDT • Sports • cnn.com
AI-generated attack ads are already slopping up Mass. races

AI attack ads are already showing up in Massachusetts races — and the 2026 cycle is just getting started.

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Mar 23 • 6:20 AM EDT • Politics • axios.com
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Noah Hiles: What I’m hearing on Pirates, Konnor Griffin extension talks

BRADENTON, Fla. — The Pirates reassigned Konnor Griffin to minor league camp Saturday, ending any hope that the game’s top-rated prospect would...

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Mar 23 • 5:38 AM EDT • Sports • post-gazette.com
Mum on his own replacement, Bennet disrespects voters

U.S. Sen. Michael Bennet is playing an arrogant game of hide-and-seek with Colorado voters as he seeks to abandon his Senate seat to become governor. Bennet insists that if he is elected governor in November, he will wait until he is inaugurated in January 2027 before he resigns from the Senate so he can unilaterally […]

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Mar 23 • 3:00 AM EDT • Politics • coloradopolitics.com
BUSINESS MONDAY: Spotlight on Sarah's Cheesecakes & Cafe in Pittsfield

The small family-owned and -operated operation is celebrating its 20th anniversary—and looking forward to many more years to come.

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Mar 23 • 12:07 AM EDT • Business • theberkshireedge.com
Crimson Desert developer apologizes and promises to replace AI-generated art

Pearl Abyss announced a comprehensive audit of its in-game assets and will replace any AI-generated content.

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Mar 22 • 2:37 PM EDT • Technology • engadget.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
3 restaurants open in Pittsburgh’s East Carson business district

Pittsburgh city leaders celebrated the opening of three new restaurants in the city’s East Carson business district on Friday.

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Mar 22 • 11:35 AM EDT • Business • wpxi.com
Homan says ‘more conversations need to be had’ to end standoff over ICE, DHS funding
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Bash: Trump celebrating Mueller’s death ‘not a surprise, but that doesn’t make it okay’
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Maine progressive Senate candidate Graham Platner responds to Gov. Janet Mills’ attack on his online past
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New Apple TV and HomePod Mini Remain 'Ready' to Launch

Apple has unveiled nine new products this month, but the wait continues for the next-generation Apple TV 4K and HomePod mini models. In his Power On newsletter today, Bloomberg's Mark Gurman said new versions of the Apple TV and HomePod mini have been "ready" since last year, but he reiterated that Apple has held off on releasing them until the more personalized version of Siri and other Apple Intelligence upgrades are released later this year.

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Mar 22 • 9:33 AM EDT • Technology • macrumors.com
AI-generated ads are trickling into political campaigns, sparking big worries

AI usage in political ads is largely regulated at the state level, but there remain concerns about how they can mislead voters.

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Mar 22 • 6:00 AM EDT • Politics • nbcnews.com
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Chuck Norris's Second Highest-Rated Movie Is One He Spent About 30 Seconds In

The second highest-rated movie associated with Chuck Norris is one he didn't even have a starring role in.

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Mar 21 • 10:16 PM EDT • Entertainment • mensjournal.com
Trump’s Reaction to Mueller’s Death: ‘Good, I’m Glad.’

The president has consistently celebrated the deaths of political foes. His response to Mr. Mueller’s death drew criticism from Republicans and Democrats.

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Mar 21 • 9:41 PM EDT • Politics • nytimes.com
Health Literacy as a Modifiable Clinical Risk Factor: Operationalizing an Underrecognized Determinant of Outcomes

Health literacy has been considered a social determinant of health and has never been extensively incorporated in the general practice of clinical care. Systematic reviews and cohort studies sho...

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Mar 21 • 8:00 PM EDT • Health • cureus.com
Donald Trump Is Nothing Like Robert Mueller

The absurdity of a man who avoided Vietnam due to “bone spurs” dancing on the grave of a decorated combat veteran

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Mar 21 • 5:15 PM EDT • Politics • theatlantic.com
47th annual Utica University science fair shows area students are smarter than ever

Four dozen science projects from 60 students from eight area schools competed for the top prizes at the Donohue Concourse underneath the Frank Gannett Library. Some of the topics may have changed over the years — there were no baking soda volcanoes — but the students still displayed their projects on decorated posterboard for staff, family and the judges to see. The projects were split between the junior division — 7th and 8th grades — and the senior division — 9th through 12th grades.

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Mar 21 • 5:00 PM EDT • Science • romesentinel.com
Robert Mueller, former special counsel who led Trump-Russia probe, dies

A decorated Marine and longtime law enforcement leader, Mueller served as FBI director before taking on the high-profile investigation in 2017.

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Mar 21 • 2:19 PM EDT • Politics • nbcnews.com
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My twins separated for the first time at 19

After doing everything together their entire lives, my twin sons separated for six weeks and hardly checked in. It was good for their relationship.

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Mar 21 • 10:42 AM EDT • Business • businessinsider.com
TAMIU planetarium reopens after major renovations

TAMIU celebrated the reopening of its renovated planetarium, now featuring advanced technology and a new immersive learning experience for students and visitors.

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The Joe Kent saga lays bare the real Trump derangement syndrome

Washington's Kent resigning from the nation's security team seemed like an accountability moment. Instead, it demonstrated how President Trump isn't held responsible for anything.

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Mar 21 • 9:00 AM EDT • Politics • seattletimes.com
Ancient DNA reveals a farming shift that pushed a society to the brink

A new study reveals that farming in Argentina’s Uspallata Valley was adopted by local hunter-gatherers rather than introduced by outside populations. Centuries later, a stressed group of maize-heavy farmers migrated into the region, facing climate instability, disease, and declining numbers. Despite these pressures, there’s no sign of violence—instead, families stayed connected across generations, using kinship networks to survive. The research shows how cooperation, not conflict, helped communities navigate crisis.

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'They most definitely misled me' | Macon business owner frustrated after Bibb leaders deny alcohol license
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'They most definitely misled me' | Macon business owner frustrated after Bibb leaders deny alcohol license
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Mar 20 • 11:31 PM EDT • Business • yahoo.com
Scientists turn probiotic bacteria into tumor-hunting cancer killers

Scientists have engineered probiotic bacteria to act as tumor-seeking drug factories. In mice, these bacteria infiltrated tumors and produced a cancer-fighting drug right where it was needed. This targeted approach could make treatments more effective and reduce side effects. More research is needed before it can be tested in people.

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Mar 20 • 8:00 PM EDT • Science • sciencedaily.com
WordPress.com now lets AI agents write and publish posts, and more

New AI agents on WordPress.com could lower barriers to publishing while increasing machine-generated content across the web.

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Mar 20 • 12:43 PM EDT • Technology • techcrunch.com
“Loyal Slaves” and Campfire Entertainment in Frank Vizetelly’s Confederate Camp

Frank Vizetelly’s illustration titled “Night Amusements in the Confederate Camp” appeared in the Illustrated London News on January 10, 1863. It was one among a number of wartime scenes that Vizetelly captured for the newspaper. Subscribe Following the war, the illustration appeared in a number of books, including John O. Casler’s Four Years in the Stonewall Brigade (1893) and Campfires of the Confederacy (1898) by Ben La Bree. The scene depicts a Confederate camp at night with an enslaved man, most likely a camp servant, performing a dance around a fire with the music provided by a soldier playing a banjo. Another enslaved man looks on at the right. Vizetelly likely witnessed the scene—one that would have been common throughout the war. It’s a wonderful example of the way in which Confederates—slaveowners and nonslaveowners alike—experienced the presence of slave labor in the army. Vizetelly was deeply sympathetic to the Confederate cause. His depiction of the enslaved man as more than happy to entertain the very people who were fighting to keep him enslaved was precisely the kind of image designed to reassure a British audience that slavery was benign, and by implication, that Britain need not feel morally troubled about recognizing or supporting the Confederacy. Share Just as importantly, the sight of a dancing slave reassured Confederates themselves that the institution of slavery remained secure even after President Lincoln signed the Emancipation Proclamation. I’ve come across this illustration many times before and I plan on using it in my next book project on the role of enslaved labor in the Confederate army during the Gettysburg Campaign, but this is not the reason I am sharing it with you today. It has to do with where I recently found it, which came as a complete surprise and is incredibly revealing. Let’s take a look.

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Mar 20 • 6:43 AM EDT • Entertainment • kevinmlevin.substack.com
March Madness scores, winners and losers: North Carolina, Wisconsin collapse, Nebraska makes history

The Cornhuskers celebrated a program first, while the Tar Heels and Badgers are in the news for all the worst reasons

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Mar 19 • 10:32 PM EDT • Sports • cbssports.com
Anthropic just shipped an OpenClaw killer called Claude Code Channels, letting you message it over Telegram and Discord

The consensus among early adopters is that Anthropic has successfully internalized the most desirable features of the open-source movement—multi-channel support and long-term memory

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Mar 19 • 9:51 PM EDT • Technology • venturebeat.com
Markiplier to Microdramas: The Ankler x NAB Show’s Future of Entertainment

Share Subscribe Vegas, baby! The Ankler is heading back to NAB Show for a second year in a row — and doubling down on conversations with the smartest people in the industry. From April 18–22, we’re partnering again with the industry’s biggest media and tech gathering to break down the Business of Media and Entertainment as it’s actually evolving: faster, riskier and increasingly driven by new formats, new audiences and new power players. This curated series will bring together top creators, executives and innovators to tackle the forces reshaping the industry — from the AI disruption of Hollywood’s creative ecosystem to the rise of the creator economy, shifting audience behavior and the changing economics of production. We’ll be rolling out more programming in the coming weeks — including top speakers from leading AI studios, prediction markets and beyond — so keep an eye on the Business of Media and Entertainment hub. But first up, we’re announcing two panels about what’s actually working in Hollywood: The Scary-Smart Business of Horror A good scare has become one of the entertainment economy’s most reliable engines. With disciplined budgets, built-in fandoms and global box office upside, horror consistently outperforms. From theatrical releases to streaming-first originals and creator-driven IP, the genre is artistically flexible and financially durable — and one of the last truly communal experiences for Gen Z and Gen Alpha audiences. Join YouTube creator Mark Fischbach, aka Markiplier, whose independent feature Iron Lung earned more than $50 million at the global box office, Atomic Monster president Michael Clear and screenwriter Akela Cooper (M3GAN, Malignant) for a conversation moderated by Like & Subscribe’s Natalie Jarvey about why horror travels so effectively across platforms and borders, how studios and independents are building sustainable genre pipelines and why the next wave of breakout franchises may emerge from unexpected sources. Inside the Microdrama Boom Short-form serialized storytelling is having a major moment. Microdramas, social-native series and creator-led narratives are capturing massive audiences with low-cost, rapid production cycles and direct-to-fan distribution. What was once dismissed as niche or experimental is now attracting major platform investment. Moderated by Jarvey, this panel of microdrama creators and executives — including one of the format’s top stars and producers, Kasey Esser, and Dhar Mann Studios’ head of vertical content, Erin McFarlane — examines how format innovation, fandom dynamics and algorithmic discovery are reshaping the economics of scripted storytelling and what traditional studios can learn from these agile models. For sponsorship opportunities, contact Lynne@theankler.com Share

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Mar 19 • 6:34 PM EDT • Entertainment • theankler.com
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AI-generated follow-up questions and answers

Appearing just below the summary bullets, these AI-generated follow-up questions and answers let readers quickly explore further context and angles.

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Mar 19 • 1:40 PM EDT • Business • businessinsider.com
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New ‘Perseus’ Android malware checks user notes for secrets

A new Android malware called Perseus is checking user-curated notes to steal sensitive information, like passwords, recovery phrases, or financial data.

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Mar 19 • 6:13 AM EDT • Technology • bleepingcomputer.com
Forum on harnessing Artificial Intelligence for health equity

Register to this forumOver the past decade, artificial intelligence (AI) has significantly evolved in complexity, performance, and utility. Its integration across a wide range of industrial sectors has accelerated, with healthcare emerging as one of the most transformative sectors. In this sector, AI has enabled high-impact applications – from enhancing the speed and accuracy of disease diagnosis and supporting clinical decision-making, to strengthening public health initiatives such as disease surveillance and workforce optimization. Moreover, AI holds immense potential to empower individuals, enabling them to take greater control of their personal health and well-being. Yet the central question remains: Who benefits, who is at risk, and do these innovations close or widen health inequities? While the potential of AI-enabled applications is substantial, many countries have approached their adoption with caution. This hesitancy stems from concerns about risks and benefits, including model bias, data breaches, privacy violations, and the erosion of professional skills due to over-reliance on AI. Additional barriers include inadequate data infrastructure and a lack of robust evidence on the most effective forms and interfaces of AI to enhance service delivery and system performance. Moreover, the rapid rise of Generative AI has introduced a heightened urgency for the development of comprehensive governance and ethical frameworks. The Asian Development Bank (ADB) Health Practice Team and Digital Sector, in collaboration with the World Health Organization (WHO) Regional Office for the Western Pacific, are convening the Forum on Harnessing AI for Health Equity on 25–26 March at ADB Headquarters. Senior health officials from 16 developing member countries (DMCs), alongside leading researchers, innovators, and policymakers from across Asia and the Pacific, will engage in discussions on how AI can be governed, financed, and scaled to deliver healthier lives for all. The forum is funded through the High-Level Technology Fund with support from the Government of Japan. Objectives The two-day forum aims to:Identify high-impact, evidence-based health AI use cases suitable for resource-constrained settings and map out a pipeline for potential supportIntroduce and validate the WHO's policy guidance on minimum necessary ecosystem for countries and institutions to self-assess readiness for AI adoptionObtain initial commitment from participating stakeholders to join a pilot regional initiative focused on data/model sharing for a priority health challengeEndorse a prioritized set of actionable policy recommendations focusing on governance, regulation, and sustainable financing necessary to scale high-impact health AI use cases in resource-constrained settings Target participants The forum will convene participants from 16 ADB DMCs including Bangladesh, Bhutan, Cambodia, Cook Islands, Fiji, Indonesia, Lao People's Democratic Republic, Mongolia, Nepal, Palau, Papua New Guinea, Philippines, Sri Lanka, Thailand, Uzbekistan, and Viet Nam. In addition, health system leaders and practitioners, private sector technologists, academic experts, representatives from civil society organizations, development partners, and philanthropic institutions engaged in AI for Health from Australia, the People’s Republic of China, Japan, Malaysia, New Zealand, Singapore, and the Republic of Korea will also be invited. SessionsDay 1 (25 March)Session 1: AI Use Cases for the Care Continuum: Improving Access and QualitySession 2: Adopting a risk-based approach for AI use case prioritizationSession 3: Establishing the Minimum Ecosystem for Implementation Risk ManagementSession 4: Future-Ready Health Workforce: Building Competency for Human-AI CollaborationDay 2 (26 March)Session 5: The Political Economy of AI in Health: Understanding Stakeholder Interests and their Impact on EquitySession 6: AI and Health Financing: Supporting Fair Coverage and ProtectionSession 7: AI Regulation and Oversight: Pathways for Different RealitiesSession 8: The Way Forward – Building Alliances and Regional Partnership How to registerThe forum will be held in a hybrid format. In-person attendance is by invitation only, while livestreaming of the forum will be available to the public. To register, please complete this form on or before 24 March 2026.Event organizers / partnersAsian Development Bank (ADB)WHO Regional Office for the Western Pacific High-Level Technology Fund (HLTF)ContactAkihito WatabeHealth Specialist, SD3-HSDawatabe@adb.org Jae Kyoun KimHealth Specialist, SD3-HSDjkkim@adb.org

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Mar 19 • 1:13 AM EDT • Health • who.int
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Frustrated Democrats walk out of tense Epstein briefing with Bondi and Blanche on Capitol Hill

When Attorney General Pam Bondi and Deputy Attorney General Todd Blanche arrived on Capitol Hill Wednesday afternoon, they hoped to boost members’ confidence on their handling of the Jeffrey Epstein investigation. Within half an hour, Democratic lawmakers had walked out.

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Mar 18 • 10:12 PM EDT • Politics • cnn.com
HHS announces first Rural Health Transformation Program funding opportunity to strengthen rural health care workforce | Health and Human Services North Dakota

North Dakota Health and Human Services (HHS) today announced the first Rural Health Transformation Program funding opportunity is now available to support the retention of health care professionals in North Dakota’s 37 critical access hospitals and their owned and operated clinics. The deadline to apply is 5 p.m. CT April 30.

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Mar 18 • 9:30 PM EDT • Health • hhs.nd.gov
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Track 15 celebrates 1 year of business

The Track 15 Food Hall celebrated one year of business on Wednesday.

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Mar 18 • 2:34 PM EDT • Business • turnto10.com
Mozilla to launch free built-in VPN in upcoming Firefox 149

Mozilla announced that Firefox version 149 will introduce a free browser-integrated VPN tier starting March 24, 2026.

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Mar 18 • 8:13 AM EDT • Technology • cyberinsider.com
I moved my company from Wall Street to Florida—wish I'd done it sooner

Webull's chief of staff and head of strategic partnerships explains the benefits of moving the company's headquarters to a less saturated market.

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Mar 18 • 5:11 AM EDT • Business • businessinsider.com
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Subnautica 2 publisher’s CEO used ChatGPT in failed bid to avoid paying US$250m bonus to own studio head, court hears

Court orders Krafton’s CEO to reinstate Unknown Worlds’ leadership after they were ousted using an AI-generated plan

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Mar 17 • 10:01 PM EDT • Technology • theguardian.com
Artists, vendors frustrated over payment issues from Colchester business

A number of artists and vendors are frustrated by late or missing payments from a Colchester business that sells their creations. They’re wondering what’s going on. For Kristy Hughes, creating beautiful art is a passion. “I do crystals and resin, and resin takes 24 hours to cure. So, each piece is days of work,” she said. Her business, Purple Goddess…

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Mar 17 • 9:48 PM EDT • Business • nbcconnecticut.com
Hundreds of health care workers from Washington, Oregon have immigrated to B.C. for jobs

More than 400 U.S.-trained health-care professionals have accepted jobs across British Columbia, nearly tripling the number reported in September 2025, provinci

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Mar 17 • 5:38 PM EDT • Health • komonews.com
Trump's security pick Mullin poised to inherit a DHS beset by challenges

Immigration enforcement is at a crossroads. Disaster-hit states and their lawmakers are angry at delayed federal assistance. Frustrated travelers face long airport security lines due to a monthlong funding battle in Congress.

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Mar 17 • 2:02 PM EDT • Politics • pbs.org
🙂 Positive (35%)
Newest cohort of top business scholars honored by Seneff, FSU president

James M. Seneff, a celebrated alumnus and major supporter of Florida State University, on Friday encouraged a cohort of elite students in the Herbert

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Mar 17 • 11:21 AM EDT • Business • news.fsu.edu
March Madness 2026 bracket: NCAA Tournament picks, predictions by top-rated college basketball model

SportsLine's model has nailed 25 first-round upsets by double-digit seeds and revealed its optimal NCAA Tournament bracket 2026

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Mar 17 • 10:45 AM EDT • Sports • cbssports.com
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The Promptory Launches First Curated AI Marketplace with Built-In AI Strategy Director for Small Business and Enterprises

FRISCO, Texas, March 17, 2026--The Promptory, a privately held technology company, today announced the official launch of its AI tools marketplace — the first curated platform built specifically to help small, medium, and enterprise businesses find, evaluate, and implement the right AI tools for their specific needs.

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Mar 17 • 9:30 AM EDT • Business • finance.yahoo.com
Chasing Olympic bobsleigh dreams in post-war Sarajevo
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Mar 17 • 7:54 AM EDT • Sports • cnn.com
Business partner of King’s cousin ‘scammed’ doctor out of £50k

A retired doctor lost £50,000 in a scam orchestrated by the business partner of one of the King’s cousins, it has been claimed.

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Mar 17 • 6:20 AM EDT • Business • yahoo.com
Strait of Hormuz: Trump needs a coalition. Here’s how to build one

The first two weeks of the Iran crisis have demonstrated military dominance by the US and Israel, with asymmetrical responses from Iran. How this plays out over the coming weeks will determine the outcome.

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Mar 17 • 12:00 AM EDT • Politics • cnn.com
The scientist who warned that profit, not science, decides which drugs reach patients

In a Genomic Press Interview published in Brain Medicine, Dr. Gabriella Gobbi, Professor of Psychiatry at McGill University, Canada Research Chair (Tier 1) in Therapeutics for Mental Health, and President-Elect of the Collegium Internationale of Neuropsychopharmacology (CINP), delivers a pointed warning: the greatest threat to drug discovery is not scientific failure but a financing system that abandons effective, affordable treatments whenever they cannot promise sufficient returns to investors. Across a career that began in central Italy and moved through Sardinia and Montreal, Dr. Gobbi has generated landmark research linking adolescent cannabis exposure to depression, identified novel melatonin receptor mechanisms in sleep and pain, and launched psychedelic neuroscience before it became fashionable. The interview reveals a scientist whose best questions have always begun at the bedside, and whose most urgent fears concern the structures that stand between discovery and patients.

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Mar 16 • 8:00 PM EDT • Science • eurekalert.org
‘Frustrated': Hollywood business owner says thieves targeted perfume store again

Surveillance cameras captured thieves smashing through the front door of a South Florida business, stealing thousands of dollars’ worth of perfume.

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Mar 16 • 6:26 PM EDT • Business • nbcmiami.com
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Top political moments from the Oscars

The film industry celebrated its biggest night of the year on Sunday amid global turmoil. At this year’s Academy Awards, actors Michael B. Jordan and Amy Madigan locked down wins for their pe…

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Mar 16 • 12:34 PM EDT • Politics • thehill.com
Integrated Crisis Stabilization Services supports individuals experiencing substance use and mental health crises at United Counseling Service’s Battelle House in Bennington, VT

As part of a State of Vermont request, United Counseling Service (UCS) created an Integrated Crisis Stabilization Program (ICSS) this year to expand its services for individuals experiencing mental health and substance use crises in Bennington County. ICSS provides therapeutic groups, skill-building, and a safe place to recover.

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Mar 16 • 11:54 AM EDT • Health • vtdigger.org
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Oregon's hospitals are highly consolidated, report shows

A Yale analysis finds about 72% of Oregon hospitals are concentrated under a few systems.

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Mar 16 • 9:18 AM EDT • Health • axios.com
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Tools to build a winning March Madness bracket
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Mar 16 • 8:59 AM EDT • Sports • cnn.com
NCAA Tournament 2026 bracket: Top-rated simulation predicts surprising upsets, March Madness picks, sleepers

When does the March Madness 2026 schedule start, and when are 2026 NCAA Tournament brackets due? The 2026 March Madness bracket begins on Thursday, March 19

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Mar 16 • 7:30 AM EDT • Sports • cbssports.com
Castlederg: Businesses say regeneration construction work impacting trade

Business owners in Castlederg say they are frustrated by the impact construction work is having on the town.

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Mar 16 • 4:33 AM EDT • Business • bbc.com
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Oscars 2026: The moments we’ll be talking about all year

From history-making wins to uplifting musical performances, the Oscars celebrated outstanding films in “very chaotic, frightening times.”

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Mar 16 • 2:04 AM EDT • Entertainment • cnn.com
Deepfake Influencers Push Supplements Online

AI-generated figures are promoting wellness products to unsuspecting consumers

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Mar 15 • 9:39 PM EDT • Technology • newser.com
A strange new quantum state appears when atoms get “frustrated”

Physicists at UC Santa Barbara have uncovered a new way to manipulate unusual magnetic states by exploiting “frustration” inside a crystal’s atomic structure. The team discovered a rare system where two different kinds of frustration—magnetic and electronic bond frustration—coexist and interact. By coupling these competing effects, researchers may be able to control exotic quantum states, potentially unlocking new ways to manipulate entangled spins for future quantum technologies.

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Mar 15 • 8:00 PM EDT • Science • sciencedaily.com
Strengthening One Health Field Epidemiology Capacity in the WHO South-East Asia Region

Recent public health emergencies—including the COVID-19 pandemic, recurrent zoonotic disease outbreaks, and the high level of antimicrobial resistance—have underscored the urgent need for strong, multisectoral field epidemiology capacities. This reinforces the importance of a workforce equipped with One Health field epidemiology competencies. To address this need, WHO works with the Food and Agriculture Organization of the United Nations (FAO), the United Nations Environment Programme (UNEP), and the World Organisation for Animal Health (WOAH), as part of Quadripartite Alliance for One Health, to strengthen field epidemiology training programmes using a One Health approach.These efforts are aligned with WHO SEARO’s Strategic Framework for Action for Strengthening Surveillance, Risk Assessment and Field Epidemiology and the Regional Roadmap to Advance Field Epidemiology Capacities 2025–2029 emphasize workforce development, multisectoral collaboration, and enhanced preparedness for health emergencies. With funding from the Pandemic Fund, The Competency for One Health Field Epidemiology (COHFE) integration within Field Epidemiology Training Programmes (FETPs) or similar initiatives has been initiated in Bangladesh and India and is planned in Sri Lanka.BangladeshIn Bangladesh, COHFE is being adapted to strengthen the Field Epidemiology Training Programme, Bangladesh (FETP-B) Advanced programme. Initiated in July 2025 and led by the Institute of Epidemiology, Disease Control and Research (IEDCR), the process brought together stakeholders from human, animal, and environmental health sectors, academia, and laboratories.A Multisectoral Working Group (MWG) was established to guide implementation, conduct readiness assessments, and identify opportunities to institutionalize One Health collaboration. Through national multisectoral consultations and a competency prioritization workshop held in Dhaka in November 2025, stakeholders identified priority technical competencies for surveillance, outbreak investigation, data analysis, and risk assessment, alongside functional competencies related to leadership, coordination, and the laboratory–epidemiology interface. The process also surfaced systemic barriers—such as challenges in data sharing and limited joint investigations—enabling targeted recommendations. These outcomes are guiding curriculum revision, the introduction of One Health simulations and joint field exercises, and the development of a national multisectoral mentorship pool, with updated training materials expected to be implemented in the upcoming cohort.Figure 1. Competency prioritization involving multisectoral stakeholders“COHFE represents a significant step forward in operationalizing the One Health approach. The collaboration between national institutions and the Quadripartite partners is critical for building resilient systems to address complex health challenges in the region.”, Prof. (Dr) Tahmina Sirin, Director, Institute of Epidemiology, Disease Control and Research (IEDCR), Bangladesh.Aligning India’s One Health Training with COHFEIn India, the National Centre for Disease Control (NCDC) has strengthened One Health workforce development through its SectorConnect initiative. WHO supported a comprehensive competency mapping and curriculum review to align the Field Epidemiology Programme in One Health (FEP-OH) with all 14 COHFE domains. The review identified strong foundations while generating actionable recommendations to strengthen One Health learning outcomes, expand joint field-based learning, and enhance competency-based assessment. These improvements are informing programme refinement and phased scale-up across additional states.Figure 2. Strengthening learning outcomes for the SectorConnect FEP OH CurriculumThrough these efforts, WHO SEARO will continue to support countries to move from separate sector-based training toward an integrated, impact-driven One Health field epidemiology workforce capable of addressing complex health threats at human-animal-environment interface.ReferencesFood and Agriculture Organization of the United Nations, World Health Organization, & World Organisation for Animal Health. (2024). Competencies for One Health field epidemiology (COHFE) framework. https://www.who.int/publications/i/item/9789240080058World Health Organization. (2023). Strategic framework for action for strengthening surveillance, risk assessment and field epidemiology for health security threats in the WHO South-East Asia Region. WHO Regional Office for South-East Asia. https://www.who.int/publications/i/item/9789290210030World Health Organization. (2024). Regional roadmap to advance field epidemiology capacities in the WHO South-East Asia Region 2025–2029. WHO Regional Office for South-East Asia. https://www.who.int/publications/i/item/9789290229544

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Mar 15 • 8:00 PM EDT • Health • who.int
St. Patrick's Day celebrated at Jupiter Irish Fest in Abacoa

At downtown Abacoa in Jupiter, the two-day festival in its sixth year featured authentic food, drinks, culture, entertainment, and live music.

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Mar 15 • 7:37 PM EDT • Entertainment • palmbeachpost.com