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King Charles' speech ‘unified’ both sides of the ‘political aisle:’ Former Margaret Thatcher aide
Former foreign policy advisor to Margaret Thatcher Nile Gardiner reacts to King Charles III's address to Congress on ‘The Story.’
Denuvo Responds to Day-Zero DRM Hypervisor Crack: "We're Already Working on Updated Security Versions"
A Hypervisor bypass recently appeared giving game crackers an alternative way to circumvent protections like Denuvo DRM. The bypass is so effective that popular game repacker, FitGirl, has declared that "all single-player/non-VR Denuvo games are now cracked/bypassed." The announcement comes after fo...
Todd Bridges reveals shocking sexual encounter with Dana Plato on 'Diff'rent Strokes' set: 'How would a 12-year-old girl know about that?'
On the latest episode of 'Hollywood Demons,' Todd Bridges opened up about the troubled life of his 'Diff'rent Strokes' costar Dana Plato, including a shocking sexual encounter on set.
'Dances With Wolves' actor Nathan Chasing Horse gets life sentence for sexual assault
Nathan Chasing Horse, best known for 'Dances With Wolves,' gets life in prison a month after he was convicted of sexually assaulting Indigenous women and girls.
How HGTV Star Alison Victoria’s Boyfriend Has Helped Her Through Menopause
The 'Sin City Rehab' star opened up about her menopause ups and downs.
Opinion | Assassination Attempts Have Unforeseen Political Consequences
Assassination attempts against sitting presidents have tended to compound their political problems and isolate them from the public.
Politics & Power: Rising tariffs, gas prices squeeze small business margins across the South
Florida State University business analyst Wayne Hochwarter joins News4JAX anchor Bruce Hamilton on this week's episode of Politics & Power to discuss whether tariffs should be adjusted to shield small importers; what short‑term relief (tax credits, grants, fuel support) would help Main Street; and how state budgets should adapt to tourism and construction slowdowns.
Politics & Power: Rising tariffs, gas prices squeeze small business margins across the South
Florida State University business analyst Wayne Hochwarter joins News4JAX anchor Bruce Hamilton on this week's episode of Politics & Power to discuss whether tariffs should be adjusted to shield small importers; what short‑term relief (tax credits, grants, fuel support) would help Main Street; and how state budgets should adapt to tourism and construction slowdowns.
Dane Arts’ fifth business conference centers community, healing
Director Mark Fraire shifted focus of this Madison event to connection, noting that many artists “aren’t trying to be businesses first.”
He Died in a Florida Jail. The Company in Charge Should Have Sent Him to the Hospital, Experts Say.
Most of the state’s jails have stopped contracting with Armor Health companies, which have been sued repeatedly for subpar care. Only one jail, where Brian Tracey died, still uses a company affiliated with Armor.
To Lower Health Care Costs, ‘We Have to Address Prices’
Health care spending in the United States continues to climb, with price growth playing a significant role, according to health policy researchers in a recent episode of NCSL’s “Our American...
‘A String Of Erratic Decisions’: National Science Foundation Advisory Board Abruptly Dismissed
The White House firing of all 24 members of the National Science Board (NSB), the group that advises the National Science Foundation (NSF), is yet another
Box to launch Box Automate service to expedite enterprise business processes, CEO says
Box is launching a service built for artificial intelligence to expedite tedious work like processing invoices and pulling key data from corporate documents, CEO Aaron Levie told Reuters on Monday. In an interview at Reuters' Momentum AI summit in New York, Levie said the company would launch the service, called Box Automate, within 24 hours. It builds on other AI programs that Box developed to put enterprises' vast and disorganized data to use.
DOJ charges suspect in White House Correspondents’ Dinner shooting
The Justice Department has charged 31-year-old Cole Allen with trying to assassinate President Trump during the White House Correspondents’ Association dinner Saturday. We discuss what we know about Allen and how Trump responded to Saturday’s shooting.This episode: voting correspondent Miles Parks, justice correspondent Ryan Lucas, and senior political editor and correspondent Domenico Montanaro.This podcast was produced by Casey Morell and Bria Suggs, and edited by Rachel Baye.Our executive producer is Muthoni Muturi.Listen to every episode of the NPR Politics Podcast sponsor-free, unlock access to bonus episodes with more from the NPR Politics team, and support public media when you sign up for The NPR Politics Podcast+ at plus.npr.org/politics.
The 1st 'Alien: Isolation 2' teaser is here, and the setting looks eerily familiar
We finally get our first look at the follow-up to 2014's Alien: Isolation, with a trailer teasing a shift planetside for the sci-fi horror sequel.
Oprah Winfrey strikes multiyear podcast, content deal with Amazon
Beginning this summer, Winfrey will produce twice-weekly video podcast episodes that will stream across Amazon platforms including Prime Video, Amazon Music, Audible and Fire TV Channels.
What’s the true risk for eating disorders with GLP-1s?
The state of Covid-19 in 2026, a hat to treat depression, and other health news from Morning Rounds
AI Tool May Spot ADHD Years Before Children Are Diagnosed
DURHAM, N.C. — Attention-deficit/hyperactivity disorder (ADHD) affects millions of children, yet many go years without a diagnosis, missing the chance for early support that can change long-term outcomes even when early signs are present.
Prison or treatment? Thousands participate in mental health courts. Half graduate — and millions are left out
This story is a collaboration between Illinois Answers and the Chicago bureau of MindSite News; sign up to receive their newsletter here. Bloomington native Shayla Woodworth had struggled with mental illness and […]
WELF sets up DFSA-regulated wealth advisory business
WELF has introduced a regulated wealth advisory business in the UAE, aimed at professional and institutional clients involved in cross-border wealth and capital movements.
Magical Abilities Removed From Upcoming Assassin's Creed Hexe, Leak Suggests
Fresh leaks point to a major change for the upcoming witchcraft-themed Assassin's Creed Hexe, and expectation of an Assassin's Creed 1 remake.
Benoit Richer, Assassin's Creed Codename Hexe game director, leaves Ubisoft
In-development title loses third major team member as Richer becomes game director at new studio Servo Games
Sega and Creative Assembly share surprise Alien: Isolation sequel teaser for Alien Day 2026
Publisher Sega and developer Creative Assembly have shared the first teaser for the upcoming Alien: Isolation sequel, and it has a new setting.
‘Shakespeare Live’ creates beauty for eyes to behold
In the halls of the Valparaiso University Center for the Arts (VUCA), you may have heard peals of laughter echoing through the halls. No, that’s not fairies, but instead, the
Assassin's Creed 1 Remake To Follow Black Flag Resynced
With Assassin's Creed: Black Flag Resynced now officially confirmed and virtually around the corner, a new leak from @xjØnathan on X, Ubisoft is also working on a remake of Assassin's Creed 1. The leak allegedly stems from someone within Ubisoft, although not much else is known about the AC1 remake....
L'Oreal chairman says Coty lacks business model
The chairman of French cosmetics group L'Oreal dismissed any comparison with struggling beauty group Coty on Friday, adding that the smaller company had no business model at all.
'Euphoria' new episode hits major character with shockingly gory surprise
'Euphoria' season 3, episode 3 just hit Jacob Elordi's Nate with a shockingly gory surprise after the character's wedding to Sydney Sweeney's Cassie.
Early attention deficit hyperactivity disorder prediction from longitudinal electronic health records
Nature Mental Health - Using electronic health records from over 140,000 children, the authors developed a neural network model that predicts attention deficit hyperactivity disorder diagnosis...
Entire NSF science advisory board fired by Trump administration
Members of the National Science Board, which the US Congress founded in 1950, were given no explanation for their termination
Pirates Drop Finale; One Mistake Opens Floodgates, Brewers’ Harrison Dominates
Pittsburgh Pirates starter Carmen Mlodzinski was rolling through three innings but ran into trouble in the fourth after a costly […] The post Pirates Drop Finale; One Mistake Opens Floodgates, Brewers’ Harrison Dominates appeared first on Pittsburgh Baseball Now.
How to Watch Watson Season 2, Episode 19
Watch Watson live with TV channel, start time and streaming info. Stream Season 2, Episode 19 on Fubo — no cable required, free trial available.
How to Watch Bob's Burgers Season 16, Episode 11
Watch Bob's Burgers live with TV channel, start time and streaming info. Stream Season 16, Episode 11 on Fubo — no cable required, free trial available.
How to Watch American Dad! Season 20, Episode 6
Watch American Dad! live with TV channel, start time and streaming info. Stream Season 20, Episode 6 on Fubo — no cable required, free trial available.
How to Watch Y: Marshals Season 1, Episode 9
Watch Y: Marshals live with TV channel, start time and streaming info. Stream Season 1, Episode 9 on Fubo — no cable required, free trial available.
Assassin’s Creed Hexe Game Director Benoit Richer Exits Ubisoft Just Months After Departure of Previous Creative Director
Ubisoft’s mysterious Assassin’s Creed Hexe project seems to be going through a rough patch, as game director Benoit Richer has announced his departure from Ubisoft.
CachyOS Introduces New Default GUI Package Manager, Kyber For NVMe I/O Scheduler
The April 2026 ISO refresh of the Arch Linux based CachyOS is now available with a variety of refinements, new hardware support, and other polishing.
The First Look at 'Alien: Isolation 2' Calls You Back for More
You'll probably be scared to death in 'Alien: Isolation 2,' but at least there'll be payphones for you to stop and catch your breath.
California Politics 360 Full Episode | CA's fight against fraud applauded by Trump administration
On California Politics 360, Ashley Zavala sits down with Patrick Penn, the USDA deputy under secretary for food, nutrition and consumer services.
Should you debloat Windows 11? The custom ISO scene is bigger than you think
"Debloating" Windows 11 addresses concerns about the user experience, but it can also introduce security flaws.
Life on the spectrum with Mason
1 in 31: That’s the number of kids identified as having autism spectrum disorder by age 8 in the US. Follow Mason, who’s on the spectrum, as he goes about his day.
Mali’s Defence Minister Sadio Camara killed amid coordinated attacks
Camara's house in the garrison town of Kati came under attack amid simultaneous attacks across the West African country.
Tri-state people in business: New hires, promotions, recognitions
Unison Solutions of Dubuque announced hiring Ethan Fessler and Parker Nelson as project managers.
‘Referendum on Sheriff Brown’: Politics and policy collide as supervisors split on jail authority bill
Disagreement comes amid a new county report showing controversial Sheriff’s Office overtime costs appear to be trending downward.
Digimon Story: Time Stranger Nintendo Switch 2 vs. Switch comparison, more frame rate and resolution details
Digimon Story: Time Stranger gets more details on Nintendo Switch 2 and Switch frame rate and resolution, plus here's a comparison.
Algeria eliminates trachoma as a public health problem
The World Health Organization (WHO) reports validating Algeria as having eliminated trachoma as a public health problem. This makes Algeria the 29th country globally to achieve this significant milestone. "Algeria’s elimination of trachoma is a historic triumph that connects the past, present, and future of public health, and is rooted in a century-long commitment," said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. "This milestone proves that with sustained political will and on-the-ground leadership from committed health professionals, we can eliminate neglected tropical diseases and build a healthier, more resilient future for all." For decades, Algeria implemented the WHO-recommended SAFE strategy to eliminate trachoma. These activities included provision of surgery to treat the late blinding stage of the disease (“trachomatous trichiasis”, TT), conducting mass administration of antibiotic treatment, carrying out public awareness campaigns to promote facial cleanliness and personal hygiene as well as improvement in access to water supply and sanitation. Trachoma is the first neglected tropical disease to be eliminated in Algeria. Trachoma is a disease of the eye caused by infection with the bacterium Chlamydia trachomatis. It is a public health problem in 30 countries and is responsible for the blindness or visual impairment of about 1.9 million people. Blindness from trachoma is difficult to reverse. Based on November 2025 data, 97 million people live in trachoma endemic areas and are at risk of trachoma blindness. Infection spreads through personal contact (via hands, clothes, bedding or hard surfaces) and by flies that have been in contact with discharge from the eyes or nose of an infected person. With repeated episodes of infection over many years, the eyelashes may be drawn in so that they rub on the surface of the eye. This causes pain and may permanently damage the cornea. In 2024, 87,349 people received surgical treatment for advanced stage of the disease, and 44.4 million people were treated with antibiotics. Global antibiotic coverage in 2024 was 39%. Outbreak News Today is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
Photos | TJ Parker & Davison Igbinosun Arrive at One Bills Drive
Scroll to see photos as Buffalo Bills 2026 second-round picks TJ Parker and Davison Igbinosun arrive for their first day at the Kaleida Health Performance Center.
Why The Narrative Around Madison Square Garden Entertainment (MSGE) Is Shifting With New Street Signals
Recent Street research around Madison Square Garden Entertainment has produced several price target moves, including individual increases of between US$2 and US$6, while the consolidated target shift sits at about US$2. Bullish initiations and fresh coverage from major firms such as JPMorgan highlight growing attention, even as the removal from Goldman Sachs' US Conviction List and more cautious targets show that opinions are still split. In the sections ahead, you will see how these...
Portland’s OMSI launches climate science exhibit
The Climate of Change/Clima de Cambio exhibit at the Nancy Stueber Natural Sciences Hall invites visitors to explore climate science through immersive displays and hands-on activities.
Brain-Gut Health Initiative supports AI-assisted diagnosis of psychiatric disorders
Psychiatric disorders affect millions worldwide, but their diagnosis still relies on clinical observation instead of standard biological tests.
Joint Budget advances school separation measure - Talk Business & Politics
The Joint Budget Committee Thursday (April 23) advanced an amendment to an appropriations bill that the sponsor said is needed for four isolated schools to detach from their existing districts....
Sheridan College to Host Lecture on Careers in Medical Science Liaison Field
Sheridan College will host a public lecture at 7 p.m. Wednesday, April 29, featuring Jenny McDonald, Ph.D., director and medical science liaison at Novartis Pharmaceuticals Corporation. The event is free and open to the public. The presentation, titled “From Bench to Industry: The Role of Medical Science Liaison,” will take place in Room 153 of […]
Best of Central Florida Community’s Choice Awards business spotlight: CPS Investment Advisors
Nominations for the Best of Central Florida Community's Choice Awards are rolling in! Don't miss your chance to recognize your favorite businesses.
4 Democratic candidates discuss race for 3rd Congressional District
In the latest episode of Battleground Politics, NBC10's Lauren Mayk spoke with the four Democratic candidates for the 3rd Congressional District.
What can lawmakers do about N.Y.'s executive budget process?
Blair Horner, senior policy advisor for NYPIRG, and John Kaehny, executive director of Reinvent Albany, spoke with Capital Tonight.
Scientists just found what keeps plant cells from growing out of control
Before seedlings can photosynthesize, they depend on fatty acids—and on peroxisomes to process them. Researchers discovered that the protein PEX11 not only helps these structures divide but also controls their size during early growth. When key genes were altered, peroxisomes grew abnormally large, suggesting internal vesicles normally keep them in balance. Remarkably, a yeast version of the protein fixed the problem, pointing to a deeply conserved mechanism across species.
Inclusive Sports Day at Edison High brings smiles to plenty of faces
The event brought more than 250 special education students from the Huntington Beach Union High School District together for a day of fun.
"The Cars That Made Us" Works as Education and Entertainment
Comic Jeff Dunham's "The Cars That Made Us" is a fun, entirely enjoyable portrait of a compelling car, one per episode.
Big Machine Records Names Allison Jones EVP of A&R
Big Machine Records/Nashville Harbor has named Allison Jones EVP of A&R. She has helped sign Thomas Rhett, Florida Georgia Line, Riley Green and more.
The ROC Podcast Episode 50: Second Chance Hiring As a Business Strategy in Idaho
In this episode, Right On Crime Idaho State Director Molly Lenty joins Britt Allen to explore the connection between reentry, employment, public safety, and why second chance hiring is becoming a key part of the conversation in business. From rising incarceration rates despite declining crime, to the real barriers people face when returning to rural
Driving systems-level change through health education - UNC Gillings School of Global Public Health
April 24, 2026 Second-year MPH student Claire Siebert's summer practicum gave her an opportunity make a systemic impact on the Federal Bureau of Prisons (BOP), where she designed a syphilis education program for incarcerated adults that is now woven into federal correctional facilities across the country.
Podcast: Call of Duty, Game Pass, and the Mario movie
It's Friday, so we have another episode of the pre-alpha GamesIndustry.biz Podcast. Once again I'm joined by Lewis Pack…
Madison Hetletved joins Essentia Health-Mid Dakota Bismarck Kirkwood Clinic to practice family medicine
The Essentia Health-Mid Dakota Bismarck Kirkwood Clinic is proud to welcome Madison Hetletved, an advanced practice registered nurse and certified nurse practitioner in family medicine.
Cuba says political prisoners not part of U.S. talks as tensions grow over reforms and pressure
BREAKING: Big Machine Records/Nashville Harbor Records & Entertainment Taps Allison Jones As EVP Of A&R
Big Machine Records/Nashville Harbor Records & Entertainment has tapped Allison Jones as EVP of [...]
'Outlander' recap: William and Jamie reunite as a new time traveler is revealed
On the latest episode of 'Outlander,' William and Jamie reunite — but Lord John's luck has run out. Read EW's recap of season 8, episode 8, titled 'In the Forest.'
Reed Hastings says entertainment industry will be least affected by AI
Netflix cofounder Reed Hastings shared his thoughts on how AI in the entertainment industry on an April 22nd episode of the "Possible" podcast.
Virginia Public Schools’ Mental Health Misstep
The harms of universal screenings for mental disorders far outweigh the benefits.
Waunakee Senior Center
333 South Madison Street, Waunakee
L'Oreal chairman says Coty lacks business model
The chairman of French cosmetics group L'Oreal dismissed any comparison with struggling beauty group Coty on Friday, adding that the smaller company had no business model at all.
Alabama Department of Corrections abruptly cancels $1 billion health care contract
Lawmakers told ADOC of the company's financial problems in 2023 before it awarded the contract to provide health care at its facilities.
Blind punk band frontman to run London Marathon
Phil Harrison, 69, will take on the challenge alongside his guide runner Dr Julia Tysoe.
Opinion | I’m One of Cuba’s Political Prisoners. When Will I Go Free?
Nearly five years in Cuban prison have taught me that the government won’t loosen its hold on power.
'Survivor' star Christian Hubicki confronts Jimmy Fallon after elimination over failed Fallon challenge
'Survivor 50' star Christian Hubicki got the chance to sit face to face with Jimmy Fallon, the man whose special appearance on the show directly led to Hubicki having to vote himself out in a shocking twist.
Ubisoft Confirms "Original" Assassin's Creed Black Flag Will Still Be Available
Resynced is a "2026 take on the original legend"
Ladies of London's Margo Stilley Says Her Panic Attack on the Show Led to Unexpected Health Discovery (Exclusive)
Ladies of London's Margo Stilley suffered a panic attack in the April 23 episode after insulting costar Mark-Francis Vandelli. In a new interview with PEOPLE, she explains that the panic attack led her to a health discovery she wasn't expecting.
New Jersey Politics (Episode 512)
On this episode of New Jersey Politics with Laura Jones: Princeton University students, led by the Whig-Cliosophic Society, NAACP Princeton Chapter, and
Trump Reposts Anti-Immigrant Tirade Calling China and India ‘Hellhole’ Places
The president touched off a furor with his post sharing a podcast episode in which the host referred to China and India as “hellhole” places.
Worms swam Earth’s oceans 525 million years ago, much earlier than scientists believed
New fossil discovery reveals 535 million-year-old worms, annelids, that were already crawling and swimming, reshaping early animal evolution.
Here’s what we know after Lake County sub experienced ‘mental health episode’ in class
Days after a Lake County substitute teacher was allegedly caught acting erratically in a high school classroom, News 6 is digging deeper into what exactly spurred the incident.
Critical Access Toolkit for Substance Use Disorder
The toolkit produced by PHI's Bridge program was developed by experts in addiction medicine. It provides educational videos and downloadable resources on need-to-know information about critical access to medications for opioid use disorder and overdose prevention tactics.
Assassin's Creed Black Flag Resynced Out July 9: Everything You Need to Know
Get all the details on Resynced including release date, PC specs, new content, the different editions available, and more.
‘Dame’ Sarah Day retires from American Players Theatre after 40 years
From ingenue to grand dame, the Madison native has played dozens of roles at the classical Spring Green repertory theater.
Blacknut Levels Up: Select Activision Publishing and Blizzard Entertainment Games Now Streamable on Blacknut
Cloud gaming hits new heights with Diablo® III, Spyro® Reignited Trilogy, Crash Bandicoot® N. Sane Trilogy, Warcraft® I: Remastered, Call of Duty®: Modern Warfare® II, and more via Ubisoft+ Premium on Blacknut Activision-Blizzard Games Now Streaming on Blacknut Cloud gaming hits new heights with Diablo® III, Spyro® Reignited Trilogy, Crash Bandicoot® N. Sane Trilogy, Warcraft® I: Remastered, Call of Duty®: Modern Warfare® II, and more via Ubisoft+ Premium on Blacknut Paris, France, April 23, 202
Inside ‘General Hospital’s Epic Crossover With Broadway’s ‘Aladdin’
Giovanni Mazza and Braedyn Bruner reveal how the episode came about and what's in store for Gio and Emma in NYC, including a meetup with the Genie himself, Michael James
Latest iPhone 18 Pro Max Dummies Suggest Thicker Camera Plateau, More Protruding Lenses
Apple is expected to bring several camera enhancements to the iPhone 18 Pro models this year, but there have been no fixed rumors suggesting these upgrades will require measurable, visible changes to the device's rear camera plateau. And yet a new series of dummies suggests exactly that. iPhone 17 Pro dummy (left) vs.
Here's How the iPhone Ultra Compares to Other Apple Devices
With dummy models of Apple's rumored foldable iPhone now circulating, YouTube channel Max Tech's Vadim Yuryev has shared images and video of the book-style form factor compared to existing Apple devices, giving us a better idea of what to expect when it launches later this year. The foldable iPhone's inner display is said to have a 4:3 aspect ratio like an iPad, and it will have an iPad mini-sized OLED display when it's opened up.
Measles exposure reported at Boston Logan Airport
BOSTON — A person with measles traveled through Boston Logan Airport on April 13, the Boston Public Health Commission reported, warning exposed unvaccinated individuals to isolate and contact healthcare providers
Scientists trace latest interstellar comet's home to a cold, isolated corner of the Milky Way
A new study suggests that the comet that rambled past us from another star last year likely originated in a cold, isolated corner of the galaxy that had yet to gel into its own solar system.
Assassin's Creed Black Flag Resynced Has a $200 Collector's Edition
Ubisoft's pricing for Assassin's Creed Black Flag Resynced has leaked ahead of the game's official unveiling — and the game will also arrive with a $200 special edition.
Scientists trace latest interstellar comet’s home to a cold, isolated corner of the Milky Way
A new study suggests that the comet that rambled past us from another star last year likely originated in a cold, isolated corner of the galaxy that had yet to gel into its own solar system.
A looming crisis could limit some of your favorite AI tools
These aren't isolated incidents; they're warning signs that getting the AI fix users crave will become harder to come by.
Nexon announces dark fantasy MMORPG Embers of the Uncrowned, set to release for PC via Steam
Embers of the Uncrowned also features 'intense action from a vivid isometric perspective', a settlement progression system, and three different player classes.
Bass, Barger meets with Trump to push for L.A. fire recovery funds
The mayor and county supervisor said they had a "high-level discussion" with the president, sharing stories about what fire survivors are experiencing day to day.
Edison Park businesses see Bears potential stadium in Arlington Heights as boost
There are some business owners in Edison Park who see a potential new Chicago Bears stadium in Arlington Heights as an economic boost.
Is tit-for-tat political gerrymandering the future of US politics?
Virginia voters delivered a major win to Democrats on Tuesday.A narrow majority voted to allow lawmakers to bypass the state's bipartisan redistricting commission. That means the Democratic-led legislature will create a map that’s more favorable to them in the midterms.It's the latest chapter in a redistricting saga that President Trump started last year, but is the tit-for-tat redistricting battle the future of US electoral politics?We speak with Democratic Virginia governor Abigail Spanberger to hear her perspective.For sponsor-free episodes of Consider This, sign up for Consider This+ via Apple Podcasts or at plus.npr.org.Email us at considerthis@npr.org.This episode was produced by Tyler Bartlam and Matt Ozug. It was edited by Tinbete Ermyas. Our executive producer is Sami Yenigun.
Nominations Now Open for WMC’s Business Friend of the Environment Awards
MADISON – Wisconsin Manufacturers & Commerce (WMC) – the combined state chamber and manufacturers’ association – opened nominations for its annual
As Democrats Outraise Republican Candidates, the G.O.P. Has This $600 Million Edge
Even as the party faces a worrisome political environment and its candidates are outraised by Democratic ones, powerful Republican groups and super PACs have built a colossal advantage.