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How Brunson's clutch scoring can lead the Knicks to a repeat title + does Giannis to the Heat make any sense?
Dodgers notes: Shohei Ohtani, Justin Wrobleski, Kyle Tucker
Tuesday was as low scoring of an affair as one could as for, as the Dodgers came away with their second 1-0 win since June 5. In what has been an unbelievable offensive stretch since May 12, Shohei Ohtani kept it going as he provided the only offense for either side, blasting a solo home […]
Latvia pilots citizen engagement in research grant evaluations
Latvia has introduced an element of citizen engagement to the evaluation of nationally funded research grants. The aim is to both create more connections between science and society, and to improve the quality of its evaluations. The move comes as research funders across Europe are experimenting with ways to improve evaluation processes in the face of a sharpened focus on science’s impact on society. Evaluators of grant applications submitted to Latvia’s Fundamental and Applied Research Programme (FLPP), the country’s main research funder, will this year have the option of consulting citizen feedback on challenges the public thinks science should focus on to inform their decisions. “In recent years, both public discussions and policy-level debates in Latvia have highlighted the importance of demonstrating how publicly funded research contributes to society, the economy and the resolution of real-world challenges,” said a source at the Latvian Council of Science (LCS), which manages the FLPP. “At the same time, research institutions themselves expressed interest in improving the project evaluation framework while continuing to ensure that funding is awarded to the highest-quality projects,” the source added. The citizen input comes from a survey that was conducted between 25 February and 16 March 2025, to which 1,737 people responded. It gathered information on what the public views as problem areas for Latvia, and the role of science and technology in providing solutions to these problems. A summary of these responses has been included as an annex to the FLPP 2026 call for proposals that evaluators can refer to, purely in an advisory manner, when judging proposals. Results from the survey show that the main problem areas identified by the public were in healthcare and public health, followed by the development of new treatment methods and medicines, and then digital technology, data security and cyber security. At the bottom of the list was research aimed at acquiring new knowledge about the universe, matter and the laws of nature. Further analysis looked at the public view of the possible role of science in solving these problems. The survey charted 4,167 individual responses based on open-ended questions that were derived from the participants’ answers. The analysis again found that medical and health sciences topped the scoring, with 788 responses referring to the field. Humanities and the arts were bottom of the list, with 625. Digging further into the details, the survey suggests citizens are aware of and concerned about a number of research areas. This includes technologies and innovation to improve the environment or reduce pollution, the development of modern military technologies and cybersecurity tools, and the development and application of artificial intelligence, among others. “We hope this initiative will help strengthen public trust in science and create a more meaningful dialogue between researchers and society,” the LCS source said, adding that it offers benefits to researchers, evaluators and to the general public. More space for citizen engagement in evaluationsThere is a gradual but increasing use of citizen engagement in research evaluation processes around Europe, especially in healthcare, but it remains relatively rare, said Henry Sauermann, a professor at the European School of Management and Technology in Berlin and an expert in citizen science.“Given that we are at a point where citizen involvement is extremely limited, there is presumably space for more, but it's not that we should do it just because we want to do it,” he told Science|Business. He said some research lends itself better to having citizen input, and this usually tends to be on the applied end of the science spectrum where the public can offer useful feedback based on their experiences. He added that advising scientists on certain topics to study is also a useful approach, in the way that Latvia is doing. “The public does fund a lot of science, there's a lot of tax money going into this. We of course do want to preserve academic freedom, but it's also not unreasonable to incorporate more feedback or input from citizens where possible,” he said. Related articlesCitizen science: where, when, and how to let the public contribute to researchHow can Europe cope with a flood of AI-assisted research grant proposals?Data Corner: Horizon Europe’s AI, digital and data call success rate is 5.2%There are several ways of involving citizens in science funding. The most minimal way is having a few representatives on a panel, such as members of a patient group or union. The most direct way is crowdsourcing funding for specific projects. There is an increasing number of online platforms that allow the public to chip in to support scientific proposals.Sauermann studied this in a recent paper and found that it can have its uses, but it still is not clear if there are benefits to it. There are various assumptions linked to citizen engagement, for example that it increases public trust in science, or that it provides a representative view of what the public thinks about science. These are not necessarily true, Sauermann found. People who participate in engagement activities tend to already be very trusting of science, and, on the whole, it is generally the well-off and well educated who contribute, giving a narrow view of public opinion. On whether citizen input can help manage the increasing number of proposals that are being submitted due to assistance from AI, Sauermann is more sceptical. “The obvious answer to the flood of AI-written proposals is AI-driven evaluation,” he said, adding that it doesn’t mean citizen engagement shouldn’t be a part of evaluations in a well thought-out manner. Southern Denmark’s successful approachOne successful example of citizen engagement in science evaluations was implemented in southern Denmark. Between 2019 and 2025, citizens in the region were invited to vote to fund one of five pre-selected projects in the field of healthcare. The project, called A Healthier Southern Denmark, was a collaboration between regional authorities, the University of Southern Denmark, and two media partners. Over the seven years, there were 75,000 votes and significant public engagement online and on social media. “It was a bit of a wild project, we’d never done something like that before and we were a bit nervous about what would be said in the media about it. But actually, people were very positive,” said Anne Kathrine Overgaard, one of the main organisers of the project from the University of Southern Denmark. The university and its researchers have learned a lot from the experience, particularly about engaging with society and shaping their research to match real-world needs. This is important with Europe’s increasing focus on competitiveness and bringing innovations to market faster, Overgaard said. She hopes to see more citizen engagement in evaluation processes and in science more broadly. “For many years, citizen engagement has been a bit of an add-on to proposals, just to check a box. But I think things are changing,” she said. It’s less about citizens just gathering data and more “about the dialogue between the public and the scientists,” she said. The initiative ended last year as the team wanted to regroup to find fresh momentum. The development of AI and AI-written proposals has made Overgaard reflect on how the project could be reworked to help evaluators. She hopes to bring it back in the future. “It could be a good idea to try this initiative again in a slightly re-worked format,” she said.
'Clarke to drop Shankland for Christie or McLean'
If we rewind 36 years to 16 June 1990 and the Italian city of Genoa, Stuart McCall was busy scoring to help Scotland secure a 2-1 win over Sweden. The former midfielder jokes that he "was always deadly from a yard out" and ultimately that victory wasn't enough to ensure Scotland progressed to the knock-out stage, but up until this weekend, it was their last win at a World Cup finals. Now the 62 year-old is assistant to Paul Heckingbottom at Preston North End, but he's also enjoying absorbing all the action from the United States, Canada and Mexico.
Dana White denounces Josh Hokit’s derogatory remarks toward Michelle Obama
Josh Hokit is making waves in the UFC’s heavyweight division, but some of his recent post-fight remarks aren’t scoring him any points with promotion officials.
Arkansas' newest pledge Davion Thompson has elite ability
Arkansas basketball point guard commitment Davion Thompson has elite scoring ability that should serve him well as a Razorback.
Birmingham restaurant reopens after failing health inspection with 53
Hotspot on Dennison Avenue SW in Birmingham temporarily closed after scoring a 53 on its health inspection due to mold, expired milk and temperature violations, but has since reopened after scoring a 97 on its fourth inspection.
Paige Bueckers scores season-high 31 and the Wings beat the Mercury 85-70
The 30-point performance was the third of Buecker's career and first since setting the rookie scoring record last August.
South African pundits stunned silent after team’s performance against Mexico
The World Cup did not get off to a hot start for South Africa on Thursday. The 2010 World Cup host faced off against one of this year’s host nations, Mexico, to kick off the 2026 World Cup, and it was never a contest. From the jump, the Mexican team looked dominant, scoring in the…
Stanley Cup final one for the ages
High-scoring, history-making, lead-blowing hockey is on full display in the Stanley Cup Final between the Vegas Golden Knights and Carolina Hurricanes. But is it among the greatest finals ever played? “Everyone that texts me is saying it’s the best hockey they’ve ever watched,” Hurricanes defenseman Jaccob Slavin said. “It’s been fun to play. There’s a […]
A $1,500 foundation model that rivals larger LLMs
Sapient researchers trained a 1B reasoning model on just 40B tokens — scoring competitively with 2B-7B models at a fraction of typical pretraining cost.
Josh Naylor's grand slam powers Mariners past Orioles, 6-3
Josh Naylor hit a grand slam during a five-run fifth inning and the Seattle Mariners beat the Baltimore Orioles 6-3 on Monday night. Randy Arozarena had three hits for the AL West-leading Mariners, who have won 10 of their last 13 games. Baltimore, which was 1 for 9 with runners in scoring position, has lost three in a row for the first time since getting swept May 18-20 at Tampa Bay.
Win over Knicks puts Spurs back in it
NEW YORK — Victor Wembanyama shook off his miss at the buzzer in Game 2 by taking over Game 3 of the NBA Finals and preventing the San Antonio Spurs from getting pushed to the brink of elimination. Wembanyama made the first two shots he attempted on Monday night on the way to scoring 32 […]
Report: U.S. Business Travel Now Accounts for More Than 2% of Economy
Business travel within and to the United States continues to be a major engine powering the nation’s economy and growth, generating $623.8 billion in total gros | Findings reveal business travel supports 6.7 million U.S. jobs and accounts for 2.1% of GDP, underscoring its role as a critical driver of economic growth nationwide.
NASA to wear Prada as luxury group pushes into space industry
Italian fashion house Prada 1913.F unveiled on Sunday the inner-layer garment set to be worn by NASA astronauts heading into space, underscoring the brand's push to be the first major luxury player to make inroads in the space industry.
Another Arsenal forward scores in pre-World Cup friendly
Leandro Trossard helped Belgium to extend their unbeaten run by scoring the opening goal in their friendly win over Tunisia on Saturday, their final pre-World Cup fixture.Photo by Emmanuele Ciancaglin...
Lynx win 7th straight, improving WNBA's best record with Natasha Howard scoring 27 points
Not worth the wait; Royals fall to Twins
Another frustrating loss chock full of missed scoring opportunities.
Dodgers on Deck: Friday, June 5 vs. Angels
The Dodgers are back home ever so briefly, with a single-series homestand this weekend against the Angels at Dodger Stadium in Los Angeles. Back in Anaheim from May 15-17, the Dodgers had their way with the Angels in a three-game sweep, outscoring the Halos 31-3. The Angels come to Los Angeles having lost 29 of […]
Popular weight-loss diet shows surprising impact on serious mental health condition
New UC San Diego research suggests the keto diet may help reduce anorexia nervosa symptoms, with 72% of participants scoring in the recovered or normal range.
Golden State Warriors 2025-26 player grades: Stephen Curry
Despite maintaining his scoring average, Steph Curry saw a noticeable decline in rebounds and assists during his 17th NBA season with the Warriors.
How to evaluate risk when TAVR patients require surgery later in life
Robert Hawkins, MD, discussed an updated risk calculator—and the latest data on SAVR after TAVR—for a new video interview with Cardiovascular Business.
Detroit Tigers takeaways: Why Jackson Jobe arrived at Tropicana Field
The Detroit Tigers beat the Rays, 8-0, in the second of three games in the series at Tropicana Field, scoring 18 runs through two games in June.
New Microsoft tool lets devs spin up AI behavior tests using text descriptions
Microsoft on Tuesday took the wraps off Adaptive Spec-driven Scoring for Evaluation and Regression Testing, an open-source framework for spinning up AI evaluations.
Everton leading the race to sign Middlesbrough’s Hayden Hackney
Everton have emerged as frontrunners to sign Middlesbrough midfielder Hayden Hackney. The 23-year-old deep-lying playmaker enjoyed a superb 2025–26 campaign, scoring five goals and providing eight a...
Mark Stone’s Return Showed Why He’s Golden Knights’ Glue Guy
The return of Mark Stone put the Las Vegas Golden Knights in their fourth Stanley Cup Finals in their nine-year history. He’s one of the best right-wing players in the league. It’s his combination of clutch scoring and understanding smart routes in the defensive zones that makes him a tough player to deal with. Mark […] The post Mark Stone’s Return Showed Why He’s Golden Knights’ Glue Guy appeared first on The Lead.
Health workers face hidden exposure to cancer-linked hazards
A study reveals high exposure to cancer risk factors among health and social care workers in Europe, underscoring the need for enhanced protective measures.
Top-seeded UCLA eliminated from NCAA baseball tournament
Makoa Sniffen's run-scoring single in the 10th inning gave the Saint Mary's Gaels an improbable 6-5 victory over UCLA on Sunday in Los Angeles, eliminating the top-seeded Bruins, who were 51-6 headed into the weekend, from the NCAA baseball tournament.
Could Dejounte Murray Be Houston’s Next Point Guard?
Forget the flashy blockbusters. This former All-Star offers the steady playmaking and scoring punch Houston requires to stabilize their backcourt while navigating a high-stakes offseason pivot.
WHO Global Code of Practice on the International Recruitment of Health Personnel amended
WHO Member States adopted a resolution to amend the ‘WHO Global Code of Practice on the International Recruitment of Health Personnel’ (the Code) and strengthen its implementation, following Member State-led consultations in the lead up to the Seventy-ninth World Health Assembly. The resolution marks an important step towards the vision that everyone, everywhere can access competent and motivated health and care workers, as a foundation for both universal health coverage and global health security. Key additions to the Code focus on: inclusion of provisions on health personnel recruited internationally for employment as care workers; applicability of the Code recommendations during emergencies; and encouraging co-investment in health systems and health workforce to ensure international recruitment results in proportional benefits for source and destination countries.Since its adoption by the Sixty-third World Health Assembly in 2010, the Code has undergone three rounds of review of its relevance and effectiveness. “We welcome the resolution’s focus on sustainable and ethical mobility of health personnel,” explained Dr Yukiko Nakatani, WHO Assistant Director-General, Health Systems, Access and Data. “The Code’s adoption in 2010 was a landmark achievement. Following this update, we encourage all countries to enhance implementation, including by viewing co-investment as a win-win.” The additions were recommended by an Expert Advisory Group appointed by the WHO Director-General. The Expert Advisory Group’s final report noted the progress in health workforce data availability, provision of migrant health worker rights and the embedding of ethical recruitment principles in national policies. It also highlighted areas of possible improvement in the Code implementation, including support for the strengthening of health systems in source countries.The adoption of the resolution follows extensive consultations led by Member States, underscoring the continued relevance of the Code in a context of increasing international mobility of health workers and growing pressure on health systems resulting from global health emergencies and funding constraints.WHO is already taking forward actions called for in the resolution. An updated version of the ‘WHO health workforce support and safeguards list’, that guides ethical recruitment practices by identifying countries facing the most pressing health workforce challenges, will be published later in 2026. As recommended by the Expert Advisory Group, this will include additional flexibility enabling countries to indicate their willingness to allow active international recruitment, or for Member States not on the list to request tailored support and safeguards. This approach reflects a more nuanced, country-led framework that balances workforce mobility with the need to protect and strengthen health systems in vulnerable settings.“I thank the members of the Expert Advisory Group, the group of Member States who led the resolution, and all Member States for their constructive engagement,” added Dr Nakatani. “Let’s bring this spirit of collaboration to our collective efforts to implement the resolution, strengthen the health workforce and build resilient and equitable health systems.”
Anthony Gordon to Barcelona: Why forward is in such high demand after scoring just six Premier League goals last season
Attacks on Health
On the occasion of this tenth anniversary of Resolution 2286, we have compiled Human Rights Watch’s documentation of attacks on health in conflict over the past decade, highlighting the global nature of this crisis and underscoring the urgent need to heed its call to develop effective measures to prevent attacks on health in conflict and to ensure meaningful accountability.
Mayer Brown secures six wins at China Business Law Awards 2026 | News
Hong Kong – Mayer Brown has won in six categories at China Business Law Journal 's China Business Law Awards 2026, underscoring the firm's
Death of doctor treating Ebola patients raises fears among Congo health workers
Doctors, relatives and Red Cross volunteers gathered in the eastern Congolese city of Bunia for the burial of a doctor who died after treating Ebola patients, underscoring growing fears among frontline health workers as the outbreak worsens.
NESN pulled Platner ad, but didn't stop it from scoring attention
A campaign ad Graham Platner booked to run on NESN may not have reached the baseball fans who tuned in to the cable network for a Red Sox game, but it might still have achieved its ultimate goal: getting the US Senate candidate attention.
Kylian Mbappé Matches Cristiano Ronaldo And Lionel Messi Goalscoring Feat
Kylian Mbappé secured a second straight Pichichi Trophy after scoring in Real Madrid's final-day win over Athletic Club.
Semiconductor decoupling. Powell's politics. Industrializing Ogaden. Free trade and the Magna Carta.
Thank you for opening your Chartbook email. Feliks Topolski, 1907-1989 8th Army’s Front, Italy 1944 Semiconductor decoupling Source: FT One thing that Jerome Powell deeply understood is that chairing the Fed under current conditions is a deeply political job. “Powell has successes and mistakes to his name. But he stands out as having thought more carefully about the Fed’s democratic legitimacy than any chair since Paul Volcker,” said Paul Tucker, a former deputy governor at the Bank of England, referring to the Fed chair who successfully fought the great inflation of the 1970s and early 1980s. … While Powell was at the Treasury in the early 1990s, he watched Alan Greenspan build relationships within the government. That convinced Powell he needed to follow the former Fed chair’s lead and spend more time in Congress than his predecessors Yellen and Bernanke. “The accountability for the Fed runs through Congress,” said Claudia Sahm, a former Fed official who is now chief economist at New Century Advisors. “That’s not just about having people on speed dial — it’s answering questions, explaining policy and getting feedback.” Source: FT Ethiopia’s PM Abiy and Nigerian business tycoon, with Chinese engineering, are driving industrialization in Ogaden/Somali region of Ethiopia. - Michael Masri’s reporting for Africa Report if fascinating. Ethiopia has launched a cluster of large industrial schemes in the Somali region, laying foundation stones for a urea plant and an oil refinery in Gode while opening the first two phases of the Ogaden LNG project. Abiy Ahmed framed the push as part of a broader strategy to link energy, agriculture and industry. “These projects embody more than industrial growth,” he said. “They represent our shared responsibility to harness opportunities, strengthen co-operation and promote peace.” The Gode urea plant, backed by Dangote Group and Ethiopian Investment Holdings (EIH), is designed for 3m tonnes a year. Dangote owns 60%, while EIH holds 40%. Officials say Dangote’s equity totals about $2.5bn, while the state provides land and implementation oversight. Gas from the Calub fields will be piped 108km to the site. Construction is slated for 40 months, with operations targeted for 2028. Ethiopia imports most of its fertiliser, spending more than $1.2bn a year for 1.5m–2m tonnes. Usage was roughly 1.7m tonnes in 2023, almost half of it urea, and demand for 2024–25 is put above 2.4m tonnes. If delivered on time, the Gode plant could cover domestic needs and allow exports to neighbours. Brook Taye, chief executive of EIH, called the venture “a significant milestone in the journey toward industrial self-sufficiency”. Dangote told the groundbreaking crowd that the complex would be integrated with gas supply and a polypropylene unit to support local inputs. He pointed to Ethiopia’s Grand Ethiopian Renaissance Dam (GERD), with a capacity of more than 5,000MW, and noted his group’s cement operations and expansion plans. The Gode refinery is being developed by Golden Concord Group of China. It is designed to process 3.5m tonnes a year of crude and condensate from the Hilala field, with associated storage. Backers say it will ease foreign-exchange pressure from fuel imports and anchor further industrial activity, including a proposed steel smelting site in Dire Dawa. GCL’s chair, Zhu Gongshan, cast the project as “a key step in Ethiopia’s path to energy sovereignty”, underscoring the Beijing–Addis ties. Financing details are still being finalised, but the refinery is central to the government’s energy-security narrative. Source: The Africa Report Dangote’s Ethiopian vision: Dangote began with cement. His crown jewel, Dangote Cement, dominates Nigeria’s market and has 10 operations in other nations in Africa. The formula has been consistent: identify sectors with chronic shortages – cement, fertiliser, sugar – commit massive local investments, and scale up to serve regional demand. Ethiopia was a natural extension of that model. In 2015, Dangote launched the Mugher Cement Plant outside Addis Ababa at a cost of $600m, with an annual capacity of 2.5 million tonnes. The investment gave him a firm foothold in one of Africa’s fastest-growing construction markets. But success came with risks. In May 2018, violent unrest led to the killing of Dangote’s country manager and temporary shutdowns at Mugher. While other investors might have retreated, Dangote doubled down. Today, he is preparing to spend $400m to expand Mugher’s capacity to 5 million tonnes, alongside a new grinding unit near Addis Ababa. Cement is just one market Dangote is targeting. Ethiopia’s enormous state-controlled sugar industry, long plagued by inefficiency and debt, has struggled for years to reform. Its Omo Kuraz Sugar Development Project, touted as one of the continent’s largest initiatives, continues to face delays and mismanagement. … The most ambitious venture of all is the planned fertiliser production complex in Gode, Somali region. Publicised on 28 August 2025, the Dangote Group and Ethiopian Investment Holdings (EIH) deal plans one of the world’s largest single-site urea manufacturing plants. The project costs an estimated $2.5bn and has an estimated capacity of 3 million metric tonnes annually, a rate that would not only render Ethiopia independent, but even a net exporter of fertiliser. EIH, the state wealth fund of Ethiopia, will hold 40%, while 60% is held by Dangote Group. … For Dangote, Ethiopia is a trifecta: Cement demand is projected to grow by 10% annually, its sugar consumption is growing with rapid urbanisation, and fertiliser demand is all but insatiable, given that farming supports the livelihood of 70% of Ethiopians. Source: The Africa Report The stakes for Abiy are high: For Addis Ababa, the $4bn fertiliser project in Ethiopia’s Somali region is no longer simply a manufacturing investment. It is increasingly being framed as a strategic state project tied to food sovereignty, import substitution and the government’s broader attempt to build economic resilience under mounting fiscal pressure. “Becoming self-sufficient in food is our main agenda,” Abiy says during the visit. “Land is needed; we have it. Water is needed; we have it. Human resources are needed; we have it.” The scale is enormous even by African industrial standards. Once operational, the plant is expected to produce three million metric tonnes of urea annually, potentially making it one of the continent’s largest fertiliser complexes. Ethiopian officials say the project now includes a 110km gas pipeline, a 120MW power plant, a polypropylene packaging facility and a two-million-tonne NPK blending plant. For a government grappling with chronic foreign exchange shortages, ballooning import bills and pressure on agricultural productivity, the numbers matter politically as much as they do economically. The decision to anchor the project in Gode is deliberate. Long viewed as peripheral to Ethiopia’s industrial economy, the Somali region is now being repositioned by the federal government as a future irrigation and agro-industrial corridor. Officials argue that the area’s vast land reserves and access to water could eventually support large-scale commercial farming capable of reshaping Ethiopia’s food economy. The government is simultaneously building housing infrastructure for about 5,000 residents near the plant, while officials project broader industrial expansion along the corridor. Abiy goes further, comparing the long-term revenue potential of the Gode development zone with Ethiopia’s flagship state enterprise. “The investments we are making in this Gode area, combined, will generate high revenue for Ethiopia, at par with Ethiopian Airlines,” he says. Source: The Africa Report Feliks Topolski 1907-1982 Topolski’s Chronicle, ‘Nazi Revival’, Vol. 8, Is. 1-2, 1960 HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. Photo by Jakub Dziubak on Unsplash If you are persuaded to click, please consider the annual subscription of $50. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Grim vision of drone warfare by Sylvie Kaufmann For contributing subscribers only. Subscribe The state of the art in Colbert-studies. Jean-Baptiste Colbert was Louis XIV chief minister from 1661 to 1683 and traditionally seen as an architect of absolutism and mercantilism. Alexander Hamilton later cited him as an inspiration in 1782. Now his legacy is disputed. Daniel Dessert, the chief critic, sees Colbert as the orchestrator not so much of an absolutist state as of an elite cabal. Would be great to have a good English-language review of this important debate. Source: lhistoire Didn’t know that the Magna Carta included free trade provisions Fighting for the right to the beach in Oregon in 1967: Source: Research Gate RAF Station – British and Polish Flags, c. 1940-45, The Ingram Collection Feliks Topolski, 1907-1989 ink and wash If you’ve scrolled this far, you know you want to click: Subscribe
Pirates Surprisingly Remain One Of Baseball's Top Offenses This Season
The Pittsburgh Pirates' offense continues to perform at a high level this season after being one of the lowest-scoring teams in the league last season.
Carrick confident Bruno Fernandes will stay at Man Utd
Manchester United boss Michael Carrick is confident skipper Bruno Fernandes will remain at the club next season. Fernandes ended the campaign by claiming a Premier League record 21st assist of the season to start the scoring in United's 3-0 win at Brighton. The 31-year-old's contract is due to expire next summer, although United do have an option to extend it by another year.
Sunderland 2-1 Chelsea: What Le Bris said
Sunderland won 54 Premier League points this season, the most by a newly promoted side since Leeds United in 2020-21 (59 points), while their seventh place finish is the best by a newly promoted team since Wolves in 2018-19 (7th). The Black Cats are one of just three sides that didn't lose a single Premier League game when scoring first in 2025-26 (P13 W8 D5), alongside Manchester United and Nottingham Forest.
Dodgers had scoring chances vs. Brewers
Being down 4-0 after the first inning put a damper in the series opener on Friday night in Milwaukee, but the Dodgers offense at least nominally threatened for most of their 5-1 loss to the Brewers. The Dodgers batted 22 times with at least somebody on base on Friday, compared to 15 plate appearances with […]
Dodgers capitalize on gift to even series with Padres
The first two games this season between the teams with the two best records in the National League West have been close, hard-fought battles going down to the wire. After not scoring in the series opener, the Dodgers found just enough offense on Tuesday and capitalized on an absolute gift from the most dominant closer […]
Goldman Sachs, Moelis Say Business as Usual Amid Iran Conflict
Goldman Sachs Group Inc.’s international co-heads say the turbulent start to the year has done little to deter clients, underscoring Wall Street’s bullish outlook despite events like the Iran war.
Supreme Court ruling throws Alabama politics into turmoil
A renewed redistricting fight deepened uncertainty over election maps, voting rights and Republican divisions, underscoring Alabama’s outsized role in national political battles.
WHO declares Ebola outbreak an international public health emergency
The WHO said an Ebola outbreak first seen in the Democratic Republic of the Congo was an international public health emergency, underscoring the world's concerns.
Mizzou baseball collapses late, closing season with loss to Texas
Mizzou rallied in the eighth inning, scoring five runs, but it wasn't enough for a late comeback. A short start by Keyler Gonzalez and inconsistent performance from the bullpen set
Chicago Fire striker extends ridiculous MLS goalscoring streak 📈
Chicago Fire striker Hugo Cuypers is on an absolute tear in MLS this season. The Belgian is on pace for a historic season after bagging his 13th goal of the campaign this afternoon against CF Montré...
Prep Sports Report: Brossart scoring machine takes team title in Class 1A girls region track meet
By Terry Boehmker NKyTribune sports reporter The Brossart girls track and field team was a scoring machine that produced points in nearly event during the Class 1A, Region 4 meet on Friday at Brossart. In 11 of the 18 events, Brossart picked up 10 points or more and finished with a 166 team total to...
Monaghan must take Armagh down the stretch
Monaghan legend and BBC pundit Conor McManus outlines what Monaghan must do to upset free-scoring Armagh in Sunday's Ulster SFC final at Clones.
Pistons pound Cavaliers to stay alive
Cade Cunningham scored 21 points as the Detroit Pistons staved off elimination from the NBA playoffs with a 115-94 victory over the Cleveland Cavaliers in their NBA Eastern Conference semifinal series on Friday.Cunningham was one of six Pistons players to finish in double figures, with Paul Reed adding 17 off the bench, and Duren and Daniss Jenkins scoring 15 points apiece.
Official: ‘Proud’ Italy starlet Inacio signs new Borussia Dortmund deal
Italian wonderkid Samuele Inacio has signed a contract extension with Borussia Dortmund until June 2029, just days after scoring his first senior goal with the Bundesliga side: ‘I want to celebrate ...
Atlanta Braves first team to reach 30 wins this season
The Braves improved MLB’s top record to 30-13 with another thrilling win Wednesday night, scoring three runs in the eighth inning to beat the Chicago Cubs 4-1.
Wembanyama leads Spurs to brink as Timberwolves routed
Victor Wembanyama scored 27 points as the San Antonio Spurs moved to within one win of the NBA Western Conference finals with an emphatic 126-97 victory over the Minnesota Timberwolves on Tuesday.San Antonio kept the points flowing in the fourth, outscoring Minnesota 35-24 to wrap up a deserved victory.
Roundup: Home resales sluggish / Restaurants squeezed / Beef imports
Barely budging: Sales of previously owned U.S. homes barely rose in April from a nine-month low, underscoring a sluggish housing market at the start of the spring selling season. Contract closings edged up 0.2% to a 4.02 million annualized rate, according to National Association of Realtors data out Monday. That was slightly slower than the […]
AHA Reframes Brain Health as a Lifelong Process
A new AHA scientific statement says sleep, mental health, pollution, and childhood adversity can shape cognitive aging and dementia risk, underscoring that brain health is built across a lifetime.
Nebraska baseball takes series against Iowa in high-scoring battle
Nebraska faced off against Iowa on Saturday. In front of their largest home crowd since 2008, the Huskers claimed the series in spectacular fashion.
Cavaliers earn must-win Game 3 victory at home, defeating Pistons 116-109 with Donovan Mitchell scoring 35 points
Cavaliers earn must-win Game 3 at home, defeating Pistons 116-109 with Donovan Mitchell scoring 35 points
Donovan Mitchell and James Harden combined for 54 points, giving Cleveland the star performances it needed.
AI lets chemists design molecules by simply describing them
Creating complex molecules usually requires years of experience and countless decisions, but a new AI system is changing that. Synthegy lets chemists guide synthesis and reaction planning using simple language, while powerful algorithms generate and evaluate possible solutions. The AI doesn’t just compute—it reasons, scoring pathways and explaining which ones make the most sense.
Hon Hai Sales Grow 30% With Expansion of AI Server Business
Key Nvidia Corp. partner Hon Hai Precision Industry Co. reported a 29.7% increase in April revenue, underscoring persistently strong spending on hardware essential for AI.
WTEN: Cowgirls Begin Play At UTR Sports NIT Championship Tuesday
LAKE CHARLES-- McNeese women's tennis, the 2026 Southland Conference regular season champions will make their second postseason appearance in program history on Tuesday, May 5 in the UTR Sports Women's Tennis NIT Championship in Rome, Georgia, at the Rome Tennis Center. The tournament runs through May 7. Live streaming will be available on PlaySight, and live scoring will be available via IOnCourt.
Barcelona’s insane scoring run puts history within reach
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We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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