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Liverpool primed for business: Bezos, Bhatia and the next steps at Anfield
Fenway Sports Group looks to be locked in talks with a consortium led by the son-in-law of Lakshmi Mittal while the Amazon founder has now been linked
GOP blocks Schumer's effort to ground taxpayer funding for Trump's Qatari Air Force One
Senate Republicans blocked Chuck Schumer's bill to halt taxpayer funding for the new Air Force One Boeing 747-8 retrofit over nuclear concerns.
AMC Entertainment CEO says one long-running entertainment debate is finally over
For six years, the entertainment industry has been locked in a debate that touched everything from studio strategy to real estate valuations to the future of a 106-year-old American institution. The question was simple and existential: did streaming permanently replace movie theaters? July 20, AMC ...
Sophie Cunningham sparks social media meltdown by speaking out to protect women's sports
Sophie Cunningham told ESPN she wants to protect young girls in locker rooms and sports from competing against biological men, sparking debate.
Dolphins, Jordyn Brooks agree to extension
The Dolphins locked up another core piece as they continue their roster rebuild.
China’s Chang’e-6 reveals why solar wind hits the Moon’s two sides differently
China’s Chang’e-6 samples have uncovered a surprising difference between the Moon’s two hemispheres. Solar wind particles penetrated deeper into the far-side soil because Earth’s magnetosphere slows the particles that reach the near side. Noble gases locked inside the lunar regolith preserved evidence of this uneven bombardment. These gases may even help scientists reconstruct the ancient history of Earth’s magnetic shield.
Texas football’s new indoor practice facility near completion
Texas football has a lot to look forward to. Not only does the program have one to two additional years of Arch Manning working under center, head coach Steve Sarkisian is also locked in for the long-haul thanks to a contract that likely keeps him at Texas until at least 2031. And for the next […]
Phoenix Suns' Devin Booker Receives Hefty Praise From New Teammate
Rookie Koa Peat reveals his commitment to supporting Devin Booker’s legendary playstyle, signaling a unified locker room as the face of the franchise reshapes Phoenix’s culture.
Platner ally Troy Jackson locks down delegates as top rivals for Democratic Senate nomination drop out
Troy Jackson locked up delegates after rivals Shenna Bellows and Nirav Shah dropped out of the race to replace Graham Platner against Susan Collins.
UCF’s Preston Cushman Focused on Going 1-0 Every Week
The veteran offensive lineman ignores outside noise to anchor a disciplined culture, eyeing a Big 12 resurgence and a chance to become UCF’s first drafted blocker since 2011.
Gordon Monson: Utah Jazz announcer David Locke grew a quiet, solitary idea into a loud, burgeoning network
Ten years in, David Locke's Locked On Podcast Network has become the country's largest — one team-obsessed show at a time
Meet JPMorgan wealth planner in your college team's locker room
Mikael Lemieux didn't talk about finances a lot when he was playing hockey. He's now helping JPMorgan get in with athletes when they're young.
Orioles sign Kyle Bradish to five-year extension
The Orioles have locked down Bradish through the 2031 season
Former NFL player arrested in connection to business fire, according to West Melbourne Police
A former NFL player is facing serious charges in connection with a fire at a West Melbourne landscaping business. Police say the suspect set fire to multiple company vehicles at Tropic Care of Florida after breaking into the property and taking a can of gas from an unlocked work vehicle Wednesday morning.
“Heartstopper” stars still haven’t seen “Heated Rivalry”: ‘We probably have very similar experiences’
Kit Connor and Joe Locke know it’s “terrible” that they haven’t seen the spicy hockey romance.
Fortnite's Skimpy New Poison Ivy and Harley Quinn Swimwear Skins Are Locked to Modes Rated 13+
Fortnite has released DC characters Poison Ivy and Harley Quinn in skimpy swimwear, and locked their use to modes rated T for Teen, or ages 13+.
Buffalo Bills quarterback is considered 'greatest of his generation'
Three names are locked into the Bills QB Mount Rushmore: Jim Kelly, Josh Allen and Joe Ferguson. This Bills backup should be the fourth.
Scientists finally solved how a common gut bacterium triggers colon cancer
Researchers solved a long-standing mystery behind how a bacterial toxin associated with colorectal cancer damages the colon. The toxin first binds to a receptor called claudin-4, giving it access to attack the cells' protective barrier. After identifying this weak point, the team designed a decoy protein that successfully blocked the toxin in mice. The discovery could pave the way for new therapies to prevent inflammation and colon tumors.
Sunscreen gets an upgrade | Investors Lab
There are hundreds of brands of sunscreen available in the United States, but not one of them contains an ingredient we all need. Bemotrizinol, a highly effective, broad-spectrum chemical ultraviolet ray blocker, has been available in Europe for decades but absent from U.S. shelves. The regulatory bottleneck was driven by a 2011 U.S. Food and Drug Administration policy classifying sunscreens as drugs. While the classification remains, consumers and innovators can welcome the news that the FDA has officially approved bemotrizinol, effective August 9, 2026. Science News's Meghan Rosen provides the coverage.
Carrier-financed iPhones in the US now get locked to that carrier
Previously, you could buy an iPhone from Apple using carrier financing and you would get an unlocked unit. There is still a way to get unlocked units, though.
Apple just closed a popular workaround for buying an unlocked iPhone
Apple has closed a workaround that let you buy an unlocked iPhone with carrier financing. Here's what changed, and what it means for you
Capitals sign 2026 1st-rounder to entry-level contract
Washington's top pick from this year's draft is already locked up, even before he steps foot in the NHL.
Apple Makes A Big Change To Carrier-Financed Device Purchases
Apple has changed their policy regarding device purchases via carrier installment. No longer will your financed device be unlocked.
47 revelatory hours with Assassin’s Creed Black Flag Resynced
To review this month’s supposed remake of 2013’s Assassin’s Creed IV: Black Flag, I must first correct the record. Assassin’s Creed Black Flag Resynced isn’t a game about pirates (and assassins) in the 18th century Caribbean. Sure, sure, that’s what the trailers would have you believe. They’ve go their clips of Edward Kenway swinging his swords and steering his pirate ship into cannon-blasting combat against British frigates. Is Resynced truly a pirate game? Of the 47 hours I spent playing Resynced over the past few weeks, I will admit I spent maybe 44 (?) of them collecting plunder with Blackbeard, drinking rum with Anne Bonny and debating the pros and cons of the lawless pirate-run settlement Nassau with Benjamin Hornigold. I may in fact have spent dozens of hours sailing to remote islands, reading treasure maps, opening messages left in bottles, sinking the odd Man o’ War with a well-timed broadside, collecting sea shanties for my crew, befriending a pet monkey, and hunting whales. I am nevertheless neither so Gullible nor so Narrow-Minded as to call the magnificent Resynced a “pirate remake.” Oh no. Forget any reviews of Assassin’s Creed Black Flag Resynced you may have read. Forget what you yourself may have played, if you’ve spent any time with the game since its launch. What Assassin’s Creed Black Flag Resynced is really about I’m here to give you the scoop (spoilers for Resynced’s Animus menu lore, which many players are probably not going to see): Assassin’s Creed Black Flag Resynced, the new game whose development was led by Ubisoft Singapore, is set in the year 2096. It’s about a societal split, about revolution, about an old Assassin’s Creed adventure repurposed in the series’ distant future as propaganda or samizdat. It’s about the overheated future of 2096, essentially conquered by the series’ well-established nefarious Templar-run company Abstergo. (In this future, Abstergo is, among other things, remaking a 2013 pirate movie called Devils of the Caribbean, but this time in VR. The VR version will be backed by a marketing plan that involves AI influencers, a 10,000-avatar “metaverse premiere event” and that manufacturing of memes aimed at “50 million VR nodes.” See what I mean about Abstergo being evil?) Resynced is about a late 21st-century population mollified by the widespread use of Abstergo’s Animus devices which let people experience the lives of historical figures culled from “genetic memories.” It’s about an insurgent faction of Assassins. And it’s about a plan to wake the population into revolutionary fervor by showing them the memories of 18th century pirate Edward Kenway, who—as depicted in the original Black Flag and again in Resynced—gradually comes to an understanding about the Assassins of his day and their centuries old fight for freedom. Resynced is also about an AI developed within the late 21st-century Animus, called Ego. It has found a way to alter genetic memories, to create and show Animus users false ones. The game is about Ego’s efforts to tell the people experiencing Edward Kenway’s memories that Kenway was wrong, that fighting against order is folly, that we should crave a world where “compliance is rewarded with power.” Who are we in this game? We’re an unnamed Animus user in 2096 who experiences Kenway’s journey virtually. At four moments during Kenway’s exploits in the Caribbean our virtual jaunt can be interrupted for 10-15 minutes, as we explore Animus “rifts” where Ego explicitly tries to tell us how wrong Kenway was. None of this is what 2013’s Assassin’s Creed IV: Black Flag was about, of course. That was a different game, even if you also spent dozens of hours pirating as Kenway in that game, across missions and a map that’s been faithfully reintroduced and rebuilt for Resynced. The 2013 Black Flag was about you playing as an unnamed researcher newly hired in 2013 by Abstergo Entertainment, the video game development wing of the Templars’ evil-corp. In that game, you were assigned to use the Animus to dive into the genetic memories of Desmond Miles, a man who died in Assassin’s Creed III and who was descended from a long line of Assassins (and at least one Templar) whose adventures were featured across the prior AC games. In 2013’s Black Flag, your mission was to plumb the Edward Kenway experience for material that Abstergo could use in productions such as the motion picture Devils of the Caribbean, though the Templars had some ulterior motives for the assignment. Resynced is therefore not a remake of 2013’s Black Flag. It’s a sequel. It is a new game about a new exploration of Edward Kenway’s pirate/assassin journey, set 83 years after the framing sequences of the original game. Resynced provides a new narrative framework that, thanks to the concept of an AI that wants to alter historical memories, arrives with creative justification to tweak a now-classic 13-year old game. That makes Resynced, already a hot seller, a tantalizing hint of where Ubisoft could go with a line of Assassin’s Creed remakes. They could remake the first game, the Ezio games, even the recent ones set in ancient Egypt and Greece. And for each, they could not just modernize the graphics and controls but expand and alter their sequences of events to use them as reference points for a conflict set in the late 21st century, as rival factions try to weaponize historical memories. Game File is a reader-supported publication. To receive new posts and support my work, even when that work consists of ravings about Assassin’s Creed’s modern day plot, please consider becoming a free or paid subscriber. Subscribe A story most players will probably miss If you didn’t know any of this, I’m not surprised. If you played the game and still didn’t catch it, I’m not a bit shocked. If Ubisoft has no plans to do more of this, I won’t fall down. Almost all of what I’ve described is optional and missable in Black Flag Resynced. I nearly missed it myself, as I planned for a breezy playthrough of an old Assassin’s Creed favorite. Instead, I found myself in a 40+ hour hunt for the “real” story, buried deeper in Resynced than any gold-filled chest. The story of 2096 is Resynced’s meta-story, told in two remote pockets of the game: 1) four optional playable “rifts” that players may find as they proceed through Resynced’s pirate fantasy , 2) in dozens of text files tucked three menus deep in the game’s barely-interactive Animus hub. Assassin’s Creed games have almost always had a meta-story about people in the 21st century (usually matching the game’s release year) and their connections to the main history portions you play. Those meta-stories have always been squeezed into the margins, though seldom as severely and as, uh, graphiaclly simple, as in recent games. Back in 2013, the modern-day exploits of you as an Abstergo Entertainment employee were prominent. They were portrayed via first-person portions that occasionally interrupted the third-person Kenway experience and could be explored for hours, complete with their own missions, side quests and puzzles. Resynced’s 2096 story—of Assassin “Watchers” vs. Abstergo/Tempar goons, of rogue AIs, of panicking scientists, of a woman wondering why her Animus-addicted husband is muttering about Mary Read (“What does he mean by Assassins?”), of a fight for the population’s hearts and minds via varying interpretations of Edward Kenway’s life choices—is mostly told through unlockable text files. The files are interesting. Offered via diary entries, intercepted chats and news reports, they present varied perspectives of a world in crisis. One set works as a narrative puzzle as it reveals the Rashomonic interpretations of a massacre, or was that a successful Assassin hit? Another favorite reveals the rising bitterness of a person who, through Edward Kenway’s journey, now shakes at the ignored evil around him. One surmises that Ubisoft is averse to putting the Assassin’s Creed’s meta-story in the way of more marketable pirate playgrounds and ninja/samurai epics. Instead, we get a better-than-nothing text-in-menus approach introduced in 2025’s Assassin’s Creed Shadows. In Shadows, players unlocked the meta-story text files largely via time-gated missions that called on the user to kill X number of enemy type Y, clear three enemy castles, re-win a three-phase fighting tournament, and other grinds. Time restrictions on accessing these missions and unlocking the files meant it could take players months to access the full story in-game. But even in the most hardcore Assassin’s Creed hangouts, the fanbase instead seemed to throw up their hands rather than grind to keep up. In Resynced, Ubisoft has shown some mercy, diminishing the amount of new text files that are tied to timed grinds. Now, most of the text-based 2096 lore are associated with “data file” collectibles that players can find in the world. That includes a batch of written entries that explain a historical link between the feudal Japan era in Shadows and the piracy adventures in Black Flag. Players who explore a lot will find dozens of data files, though the game does not appear to offer any in-game tracker for finding each one. You just need to keep looking for them. As of this writing, I have most of them, but not all. I can’t find any full guide for them online. And even Ubisoft’s optional $5 microtransaction that reveals lots of items in-game does not appear to reveal the locations of the text files (at least the official description omits them from its collectibles list). That’s not a huge bother, because tracking the data files down compelled me to re-explore the waves and islands of Black Flag. That was a thoroughly pleasant task to do for the first time in a dozen years. I expect many players, though, will be content to wait for the files to be reproduced in an online AC wiki somewhere, the easier to read on a web page. It may not seem enticing to play a video game in order to gradually unlock pages of text to read. Why not, you may ask, just read a book, where they put the pages in order? For one, they’ve not tucked this latest installment of Assassin’s Creed’s meta saga in a book. I also enjoy the unordered delivery, the dawning comprehension of a story about 2096’s desperate people and questionable tech, which I glimpsed first at its middle, then the end, then the front, then other moments in between1. I am also enamored with the idea of the Assassin’s Creed games I’ve previously played, including Black Flag, being repurposed for an information war. The ideas in Resynced’s meta-story, which builds off characters and ideas in Shadows’ chunks of text, are strong. The potential of where they could go with it is exciting. As for the pirate stuff? Looks great, controls pretty well, is fun to play and oh so speedy in terms of how much of a good time you can have with each sit-down. It never gets old to chase a new shanty page across a rooftop, bombard a fort with upgraded mortars or use a diving bell to explore sunken wrecks (hats off to the team at Ubisoft Barcelona that worked on the underwater portions in Resynced; that team is now facing layoffs, such is the misery of modern gaming and oft-troubled Ubisoft). New pirate missions in Resynced involving new ally characters are brief, dramatic and add more to Edward’s story, even if the gameplay perks they provide barely enhance the gameplay. A new denouement for high-class pirate Stede Bonnet is affecting; a new hunt for Blackbeard’s treasure is a welcome extra moment. A new epilogue to hunt down a pirate killer, on the other hand, over-complicates Kenway’s character. The ending credits remain my favorite of any game I’ve ever played. Black Flag provides great source material. The revisit is well-made and a great sign of what could be. It is offered in a different wrapper that hints at an opportunity for more interesting remakes to come, should Ubisoft choose to pursue such treasures—and as we brace to resist or comply with an Abstergo future. 1 The messages that Edward Kenway finds in bottles tell another out-of-order story, one about a man reckoning with the strange memories and voices he’s heard in his head since he was a boy. That tale was also in the 2013 game and develops into one of Black Flag’s most compelling character arcs. In Resynced, it has lost its climax, because the bottle story previously paid off in the halls of the first-person Abstergo Entertainment, which is exclusive to the older game. An altered resolution, written by the 2013 game’s lead writer is fine, doesn’t invalidate the 2013 version, but makes for an inferior final note.
James Cook Highlights "New Energy" In Buffalo Bills Locker Room
As Joe Brady takes the reins, star running back James Cook details the revitalized atmosphere fueling Buffalo's high-stakes pursuit of a Super Bowl title following major coaching changes.
Johnson scores win as conservative rebels end House floor blockade over voter ID bill
House conservatives blocked legislation to pressure Senate action on the SAVE America Act, but Speaker Mike Johnson proposed a deal to end the standoff.
Upcoming OLED iPad Mini Allegedly Uses 60Hz 8.4-Inch Display Panel
Apple is allegedly using a 60Hz 8.4-inch display panel in the upcoming OLED iPad mini, which is expected to be released later this year. The information comes courtesy of a hit-and-miss tipster running the account "yeux1122" on the Korean Naver blog. The leaker claims to have been told by a source in Apple's supply chain that the unreleased iPad mini is equipped with a low-temperature polycrystalline silicon (LTPS) backplane hybrid OLED panel clocked at 60Hz.
Timberwolves Reportedly Sign Former Duke Star to $9.3 Million Contract
Minnesota locked in second-round pick Isaiah Evans on a four-year deal.
Payback politics? Wu backs challengers to state senators who blocked her tax plan
In a highly unusual move in the insular world of Massachusetts politics, Wu is the first mayor in recent memory to openly campaign against state senators who have blocked her priorities.
Scientists strike invisible gold in the deep sea—locked inside fool's gold
Pyrite, an iron sulfide ore, is often known as fool's gold because its shiny metallic luster and pale brass-yellow color can easily fool the untrained eye into mistaking it for real gold. This time, however, ...
N.H. lawmaker clocked at 107 mph asserts ‘legislative privilege’
The state representative likened her situation to that of an EMT or police officer responding to an urgent call. What was her emergency? She hasn’t said.
Despite having an offline mode, Assassin's Creed Black Flag Resynced was unplayable when Ubisoft Connect went down
Assassin's Creed Black Flag Resynced players on PC were shocked to find that a Ubisoft Connect outage has locked them out of playing the game.
Europeans Have 'Changed' Their Opinion Of America During World Cup
It's official: Europeans have changed their opinion of America during the 2026 FIFA Men's World Cup. Thousands of Europeans, from countries like England, Norway, Switzerland, Spain, etc. flocked to North America for the 2026 FIFA Men's World Cup. While the United States, Mexico and Canada acted as ...
49ers 1st-Round Pick Flagged After ‘Subpar’ Rookie Season
PFF's Bradley Locker put "subpar" 49ers edge rusher and 2025 1st-round pick Mykel Williams on list of players under Year 2 pressure. The post 49ers 1st-Round Pick Flagged After ‘Subpar’ Rookie Season appeared first on HEAVY.
An American Politician is Blocked by Israeli Settlers in the West Bank
Representative Ro Khanna was barred from leaving for 90 minutes. Where past U.S. leaders toured the region to show support for Israel, today’s Democratic presidential aspirants are going to bolster their credentials as critics.
NVIDIA GPU Hotspot Temperature Has Been Unlocked Through Mods, & Shows Widespread Thermal Issues Affecting RTX 50 GPUs That Throttle Gaming Performance
Mods have unlocked NVIDIA's GPU Hotspot measurement, which can give you a clue why your latest card is running at lower performance.
Bucs Fare Better in New NFL Power Rankings
Bolstered by fresh talent and a weak division, Tampa Bay aims for a resurgence, yet looming locker room tensions and a coaching hot seat threaten its stability.
XBOX Gamer Wins Digital Library Lawsuit Against Microsoft
In Brazil, one gamer has won their lawsuit against Microsoft over a locked account and blocked digital games library.
“Survivor” winner Dee Valladares officially revealed as final “Big Brother” season 28 player
The reality TV champ was unveiled on “Big Brother: Unlocked”
Striking Mass General Brigham home health clinicians picket outside headquarters: "We're at our breaking point"
While 4,000 Brigham and Women's nurses are locked out of the Boston hospital following a one-day strike, 450 home health clinicians are on day 3 of their week-long work stoppage.
NYU Langone, Other NY Hospitals Blocked from Releasing Trans Youth Health Records
In May 2026, a federal grand jury in Fort Worth sent a subpoena to NYU Langone Hospitals, demanding that they turn over the identities and sensitive health information of any patient who had received medical treatment for gender dysphoria at the hospital while they were under 18 years old between January 2020 through May 2026.
Campaign staffers keep trying to bet on races despite push to curb insider trading
Kalshi says it has blocked "dozens" of trades from campaign insiders, but experts say the company's approach leaves lots of potential loopholes. NPR has found at least one trade that slipped through.
iPhone Ultra Reportedly in Mass Production, No Delay Envisaged
Apple's foldable iPhone is on track to ship in September despite rumors of a delayed launch, reports Chinese financial outlet Cailian Press. The outlet says it spoke with several people within Apple's supply chain, who indicated that the device's design was locked in some time ago and that the foldable is now in mass production.
Slotkin, Ossoff Demand Answers After Hegseth Denied Military Officers’ Promotions for Political Reasons
WASHINGTON, D.C. — Today, U.S. Senator Elissa Slotkin (D-MI), Senator Jon Ossoff (D-GA), and colleagues are demanding answers after reports that Secretary Hegseth denied military officers’ promotions for political reasons. Secretary Hegseth reportedly blocked the promotion of eight Navy captains to be one-star admirals –– including the promotions of two female officers and two Black officers. “We write concerning reports […]
Gotham FC to move to NYCFC’s Etihad Park in Queens in 2028
Gotham will have its own locker room inside the MLS stadium.
NFL Analyst Claims Vikings’ Locker Room Could Get Ugly
The Minnesota Vikings will host a quarterback competition at training camp in three weeks, and for the most part, fans […]
Key Health Care Panel Is Again Blocked From Meeting Under RFK Jr.
The United States Preventive Services Task Force has been stymied under Health Secretary Robert F. Kennedy Jr.
Scientists solve a 30-year rye pollen mystery that could transform cancer research
Scientists have finally solved a nearly 30-year-old mystery surrounding two unusual molecules found in rye pollen that once showed an intriguing ability to help animals fight tumors. By determining their exact 3D structures, researchers have unlocked the blueprint needed to investigate how these natural compounds interact with the immune system and which parts may be responsible for their cancer-fighting effects.
Marvel Tokon Blocked in 132 Countries, and It Looks Like PSN Requirements Are to Blame
PlayStation and Arc System Works' Marvel Tokon: Fighting Souls has been blocked in 132 countries in what appears to be another example of Sony's PSN requirements barring players from access on Steam.
Marvel Tōkon: Fighting Souls is blocked in 132 countries due to Sony's controversial PSN linking requirement – but its Steam page is still visible
Marvel Tōkon: Fighting Souls is blocked in 132 countries, once again due to Sony's controversial PSN linking requirements.
These 10 Medications May Raise Your Risk of Heat-Related Illness
As summer temperatures climb, so do the risks of heat-related illnesses, particularly for those who take certain medications, such as GLP-1s, diuretics, antidepressants, and beta-blockers. Here's what you need to know to stay safe.
Scientists Just Unlocked an Endless Army of Cancer-Fighting Cells
The 'big eaters' are on the way.
Scientists Just Unlocked an Endless Army of Cancer-Fighting Cells
The 'big eaters' are on the way.
Sony's Marvel Tokon Blocked In Over 100 Countries On Steam
Unsurprisingly, these are the same 132 countries that were originally blocked from purchasing Helldivers 2 on Steam
32 dogs seized from Iowa breeder who allegedly blocked inspections of her business
Law enforcement officials have seized 32 dogs from an Iowa breeder facing civil charges related to inspections of her facility in Farmington.
Court Stops USDA From Enforcing Funding Conditions Tied to DEI, Women’s Sports
The U.S. District Court for the District of Massachusetts recently blocked the U.S. Department of Agriculture’s (USDA) efforts to withhold funding from states and grant recipients that have not confirmed their compliance with Trump administration policies on diversity, equity, and inclusion (DEI), “gender ideology,” women’s and girls’ sports, and immigration.
Federal judge blocks Postal Service from carrying out Trump mail-in ballot order
A federal judge blocked the U.S. Postal Service from implementing President Donald Trump's executive order on mail-in ballots nationwide, citing a 2020 agreement.
Bonus 236: A Term of Self-Inflicted Wounds
Within minutes of the Supreme Court handing down the birthright citizenship ruling on Tuesday and rising for its summer recess, its defenders were pointing to that decision (alongside the late-arriving mail-in ballots ruling on Monday and the tariffs ruling from February) as decisive proof that the Court really is “above politics,” and that criticisms of the justices for behaving more like politicians in robes than like judges are thus unfair. For a particularly thoughtful version of this claim, see Professor Will Baude’s opening response to the latest New York Times written roundtable about the Court with Baude, Professor Kate Shaw, and me. In that roundtable, I already offered one of the two major arguments against this thesis—that it’s an assessment of the numerator without regard to the denominator, and that a full account of the Court’s behavior throughout OT2025 suggests that the Court behaved even more politically during the current term than during even the previous (highly politicized) one. Just to take one of many data points, last term (OT2024), there were six rulings in argued cases in which all six Republican-appointed justices were in the majority and all three of the Democratic appointees were in dissent (along with a slew of such rulings on the emergency docket). This term, there were … 13. (Along with two 6-3 summary reversals and 10 rulings on the emergency docket from which the three Democratic appointees all dissented.) Today’s bonus issue addresses the flip side of that coin. In particular, below the fold, I identify four different moments in which the justices could have acted in ways to specifically defuse charges of political behavior—and opted instead to lean all the way in. As much as end-of-term narratives focus on what the Court did, and on the takeaways from individual rulings, consider today’s post an attempt to identify opportunities that the Court missed, as well. At least in the examples discussed below, by opting for the outcome that made the Court look more transparently political, the Court inflicted a series of (unnecessary) credibility wounds on itself. For those who aren’t paid subscribers, we’ll be back Monday with our regular coverage of the Court. For those who are, please read on.
Landlocked Colorado’s sea-change primary
Colorado’s primary elections held in the doldrums of early summer tend to be routine affairs, most often predictable and by the book. Tuesday’s battlefield was anything but. It is no exaggeration to call it a sea change. Its ripples will shape our state’s politics for many years to come. Writing on this morning after, let’s […]
Victor Marx Won’t Say How Many People He’s Killed
Colorado’s Victor Marx, who is locked in a too-close-to-call race after Tuesday’s primary, has some unorthodox ideas.
Mario Kart World 1.7.0 update out now, new Knockout Tour routes added
Mario Kart World has just received a hefty 1.7.0 update. Nintendo Switch 2 users should be seeing the version roll out now. This update brings quite a lot to the table, with the headliner being two new routes in knockout tour. They have also added the ability to use unlocked stickers in photo mode, balance adjustments, and a whole lot...
The Lasting Consequences of Bad Climate Science
The retirement of flawed baseline emissions scenarios will initiate changes across energy policy, regulation, and law.
Exec blames malware threat for Amazon blocking sideloading on new Fire Sticks
New Fire Stick OS helps Amazon block third-party homepage launchers, ad blockers.
“Big Brother: Unlocked” announces hosting shakeup and new game twist
Taylor and Derrick are back, but with a new cohost.
Colorado Supreme Court: Redistricting plans for 2028 election cannot proceed under state constitution
The Colorado Supreme Court blocked all attempts at redrawing congressional district boundaries for the 2028 election from reaching the ballot on Monday, concluding each of the proposed ballot measures violated the constitutional single-subject requirement. The court considered five distinct, but related, ballot measures. Three proposals would have redrawn U.S. House of Representatives districts to give […]
Scientists discover an unexpected way to make pancreatic cancer cells self-destruct
Researchers tested experimental PCAI compounds against pancreatic cancer cells and found they had powerful anticancer effects. One leading compound blocked more than 90% of cancer cell migration, suggesting it could help prevent the spread of tumors. Rather than suppressing cancer signaling, the treatment hyperactivated key pathways until the cells essentially self-destructed.
The strangest transfer story of 2026 starts with a loophole
By entering the portal as a track athlete, he unlocked a path most football players never consider.
Lyles to take charge of Ultimate Championship entertainment
Noah Lyles has been announced as an Ultimate Star for the World Athletics Ultimate Championship, taking place from September 11-13 in Budapest, Hungary.Lyles, the dominant US sprinter who has won consecutive 200m golds at the past four World Championships, is locked in to compete at the inaugural edition of the new global championship. Lyles has earned automatic qualification into both the 100m and 200m by virtue of his podium-topping performances in those disciplines at the Paris 2024 Olympic Games and the World Athletics Championships Tokyo 25, respectively.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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