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Lincoln County billboard falls during storm, lands on business
A billboard that was knocked down during a storm Friday night ended up landing on American Family Home Sales in Lincoln County.
Points threat will not knock us
West Bromwich Albion head coach James Morrison has banned talk of a potential points penalty.
Stephen Curry praises Al Horford after clutch shooting vs. Clippers
19-year NBA veteran Al Horford came up big for the Warriors in Wednesday's win versus the Clippers, knocking down four three-pointers in the fourth.
NBA Playoffs 2026: NBA reviewing 'dangerous' LaMelo Ball trip of Bam Adebayo that knocked Heat center out of play-in loss
NBA play-in: Heat upset LaMelo Ball wasn't ejected for tripping Bam Adebayo on 'dangerous' play that knocked Miami center out of game
Mamdani Embraces Socialist ‘Pothole Politics’ in Knockdown Center Barn Burner
The mayor marked his first 100 days on the job in an event aimed at celebrating city workers while extending the energy of his successful campaign — with a surprise appearance by Sen. Benie Sanders.
Judges keep knocking down weak DC gun cases brought by Jeanine Pirro’s office
The Trump White House touted its surge of National Guard members to Washington, DC, last summer as the way to put more dangerous perpetrators in the nation’s capital behind bars. But in nearly a dozen criminal cases since the surge began, people who were found to be carrying weapons and charged in federal court have walked free.
Goldman warns of 'very painful' gas shock if disruptions persist
Qatar, which accounts for roughly one-fifth of global liquefied natural gas supply, has seen its infrastructure knocked offline following recent attacks.
Warburton 'knocking on door' for World title shot
Gerome Warburton stunned former British champion Nathan Heaney with an unanimous win to secure the WBA Continental Middleweight title in March.
Sporting v Arsenal: Champions League quarter-final first leg
Minute-by-minute report: Can Arsenal put their recent knockout woes behind them with a result in Lisbon? Find out with Yara El-Shaboury
Dricus Du Plessis reveals his favorite fighters
Everyone has favorite fighters they like to watch, or that they relate to for whatever reason. Former UFC middleweight champion Dricus Du Plessis is no different. During a recent fan question and answer session, Du Plessis was asked which fighters he admired and why. "Stillknocks" listed mostly ...
Arteta on key fitness news, doubters and hunger
Arsenal boss Mikel Arteta has been speaking to the media before Tuesday's Champions League game against Sporting CP at Estadio Jose Alvalade (kick-off 20:00 BST). On the latest team news, Arteta confirmed defender Gabriel is fit after coming off with a knock in the defeat to Southampton in the FA Cup.
Sharon Stone Reveals Surprising Actor as ‘Best Kisser in the Business’
Stone admitted that the A-list actor 'knocked me out' with his smooching skills.
UConn completes comeback on a prayer 3 to knock off Duke, head to Final Four
UConn overcame a 19-point deficit to knock off Duke in the Elite 8 and advance to the Final Four as Braylon Mullins' last-second deep 3 won the game.
Highlights! Itauma Erases Franklin With Vicious Uppercut
Rising boxing sensation Moses Itauma was back in action earlier today (Sat., March 28, 2026), as the undefeated (14-0) Heavyweight knockout artist took on Jermaine Franklin inside Co-Op Live in Manchester, England. Known for finishing his foes early — with 12 of his knockouts coming in under three rounds, eight in the first — it […]
Canadian business stalls over US trade deal jitters
STORY: The Canadian manufacturing hub of Windsor is home to thousands of small and specialized part makers and caters primarily to car companies and equipment manufacturers. The city thrives on close integration with Detroit, America's automotive capital, just across the river.That means it's also on the frontline of tariff and trade uncertainty with Canada's largest trading partner. JACKIE RAYMOND: "Even if we don't directly work with the automotive industry, we indirectly do."Jackie Raymond is co-owner of FASTSIGNS, a Canadian company that designs and installs custom business signs and graphics.The company is coming off its toughest year since the pandemic. Orders from its core automotive clients dried up.And while a new project brought some relief, the company says customers are placing smaller orders, demanding longer payment terms, and bargaining harder on prices.:: FileIt all points to uncertainty tied to the United States-Mexico-Canada Agreement, which is up for review this year. It's a deal U.S. President Donald Trump has repeatedly said he could scrap.:: Washington, D.C. / December 2, 2025TRUMP: "...and we'll either let it expire or we'll maybe work out another deal with Mexico and Canada...":: FileThe agreement - known as CUSMA north of the border - exempts most Canadian goods from U.S. levies.While Mexico has started formal negotiations with the U.S. over the deal's renewal, Canada has so far only held informal talks.RAYMOND: "I think the CUSMA is very, very important because it trickles down to every little business right down to your barber shop and your nail shop, which will affect all of our customers."The situation in Windsor reflects a broader unease facing Canada's economy, which contracted 0.6% in the fourth quarter. About 90% of the city's exports cross the border, often multiple times during production.Manufacturing accounts for nearly a quarter of employment in the Windsor-Essex region.Its chamber of commerce, which represents about 750 businesses, says companies paused investments, delayed production, and cut jobs at the height of the tariff uncertainty last year. :: FileWindsor partly regained its footing as Trump exempted USMCA-compliant exports from Canada from tariffs in March last year.But uncertainty still drags on business confidence and Windsor's unemployment level remains one of the highest among major cities in Canada.Local shops complain of lower traffic and restaurants report thinner crowds.And builders say the housing market – often among the first sectors to show strain from the knock-on effects of tariff uncertainties – is near a standstill.Brent Klundert of BK Cornerstone, a local real estate builder, said he laid off 13 of his 21 staff as sales and prices slumped last year. "And you know, when people are going to make the biggest investment of their life, they really want confidence in their job, in the longevity of their job in the economy itself. And people lost that due to the tariffs.” // “If we can get through CUSMA, if we can get through our trade agreements with the US, I think that that will add a lot of confidence into the marketplace that we've been lacking.”Since January Klundert has rehired 10 of his employees, hoping homebuyers would start coming back.So far, only a few have.
Byfield to keep knocking the door for black bosses
Walsall head coach Darren Byfield says he will keep "banging the drum" for there to be more black managers in football.
Lindenwood knocks off Mizzou for first time ever
The Tigers dropped a midweek game to in-state foe Lindenwood on Wednesday in St. Charles. But the real bad news was how poorly the Tigers executed in virtually every category.
"The Hall of Fame Knocks: Class of 2026" nominated for Sports Emmy | Pro Football Hall of Fame
“The Hall of Fame Knocks: Class of 2026” has been nominated in the Outstanding Edited Sports Special category as part of the 2026 Sports Emmy Awards.
From The Sports Desk: Cinderella’s rough weekend
Iowa knocked off the defending champions, Florida, in a rare upset over the weekend in the NCAA tournament.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
March Madness upsets: Tracking broken NCAA tournament brackets as High Point stuns Wisconsin, VCU knocks off North Carolina in OT
The rise of the AI knock-off McKinsey consultant
Developers are building AI agents modeled on the work of consultants. We asked a former McKinsey consultant to test it out.
86 days to the World Cup: Why going undefeated doesn't guarantee a knockout-round appearance
Trump threatens to ‘knock the hell out of’ Iran's Kharg Island in impromptu phone call with PBS News
The comments came during a three-minute phone call Monday morning with PBS News' Liz Landers, while the president was attending what he described as a “very important meeting” on the Iran war.
AP analysis: Two weeks into war with Iran, Trump has been knocked back on his political heels
President Donald Trump has grown more agitated with news coverage and has failed to explain the Iran war — or how it will end — in a way that resonates with the American public.
As Iran war knocks Trump back on his political heels, he lashes out a news coverage while taking flak from top MAGA figures
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Two weeks into war with Iran, Trump has been knocked back on his political heels
WEST PALM BEACH, Fla. (AP) — In the two weeks since the U.S. and Israel launched strikes on Iran, President Donald Trump increasingly has been knocked on his political heels. He'
Two weeks into war with Iran, Trump has been knocked back on his political heels
WEST PALM BEACH, Fla. (AP) — In the two weeks since the U.S. and Israel launched strikes on Iran, President Donald Trump increasingly has been knocked on his political heels.
Two weeks into war with Iran, Trump has been knocked back on his political heels
Two weeks of war in Iran has President Donald Trump increasingly knocked back on his political heels
How mixed messaging on Iran may have Trump reeling politically
Two weeks of war in Iran has President Donald Trump increasingly knocked back on his political heels.
Two Weeks Into War With Iran, Trump Has Been Knocked Back on His Political Heels
WEST PALM BEACH, Fla. (AP) — In the two weeks since the U.S. and Israel launched strikes on Iran, President Donald Trump increasingly has been knocked on his political heels. He's grown more agitated with news coverage and has failed to find a way to explain why he started the war — or how he will ...
Warriors' tailspin continues as injuries knock out 4 more players during loss to T'Wolves: 'We're going through it'
100 firefighters knock down flames at downtown LA business
Mavericks Share Klay Thompson Injury News in 15th NBA Season
Klay Thompson has been on a heater for the Dallas Mavericks of late. The 35-year-old has played four straight games for Dallas, averaging 17.3 points on 47.1% shooting in 23.3 minutes off the bench. The five-time All-Star has also knocked down 4.5 triples per contest on a highly efficient 43.9% clip.
Power outage stalls business at Mass. State House
A State House electrical outage ended around noon Thursday after the Legislature’s website and internet connectivity within the building were knocked out of commission Wednesday evening. Legislative Information Services sent an email to legislative members and staff on Wednesday around 9 p.m., stating that an electrical outage in the State House caused a service disruption. Portions of the building were running…
World Baseball Classic: United States sneaks into quarterfinals with Italy's dominant win over Mexico
The United States will reach the knockout stage after all.
Iranian Officials Knock Down Rumors Over Supreme Leader Mojtaba Khamenei's Health
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Quentin Tarantino rips Rosanna Arquette for criticizing his use of N-word in films
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Hims & Hers Health and Novo Nordisk End Lawsuit Over Weight Loss Medications, Enter Collaboration
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NASA successfully kicks asteroid off course in Earth defence test
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California whiz kid’s science experiment draws FBI probe: ‘Surprising situation’
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Jacobs' 21 help Southern knock off Alabama State 71-64
MONTGOMERY, Ala. (AP) Michael Jacobs had 21 points in Southern's 71-64 victory over Alabama State on Tuesday night.
John Cornyn and Ken Paxton Head to Runoff in Senate Republican Primary
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Sutton's predictions: Everton v Burnley
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Trump tells CNN the ‘big wave’ is yet to come in war with Iran
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UC San Diego knocks off Cal Poly 80-64
SAN DIEGO (AP) Alex Chaikin scored 17 points as UCSD beat Cal Poly 80-64 on Saturday night.
Pakistan knocked out as New Zealand reach semis
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Bland scores 14, Saint Peter's knocks off Manhattan 75-65
JERSEY CITY, N.J. (AP) Brent Bland and Bryce Eaton each scored 14 points as Saint Peter's beat Manhattan 75-65 on Friday night.
Sparks' 19 help Fairfield knock off Siena 72-58
FAIRFIELD, Conn. (AP) Braden Sparks scored 19 points as Fairfield beat Siena 72-58 on Friday night.
Connor McDavid, Leon Draisaitl lead Oilers' 8-1 rout of struggling Kings
Connor McDavid secured his ninth 100-point season with a goal and an assist, Leon Draisaitl had a goal and three assists, and the Edmonton Oilers snapped their four-game skid with an 8-1 victory over the Los Angeles Kings on Thursday night. McDavid scored his 35th goal and Draisaitl got his 30th during his fourth four-point game of the season as the Oilers again routed the opponent they've knocked out of the first round of the Stanley Cup playoffs in each of the past four seasons.
Johnson scores 25, Kennesaw State knocks off Liberty 74-65
KENNESAW, Ga. (AP) RJ Johnson scored 25 points as Kennesaw State beat Liberty 74-65 on Thursday night.
Standout Stats
The Juventus Men's First Team was knocked out of the Champions League by Galatasaray in the play-off stage, despite winning the second leg at the Allianz Stadium 3-2.Let's take a look at some of the n...
Grand Canyon knocks off UNLV 80-67
PHOENIX (AP) Jaden Henley had 28 points and 11 rebounds as Grand Canyon beat UNLV 80-67 on Wednesday night.
Study Hall: Mizzou 73, Tennessee 69
Mizzou and Tennessee in a knock-down, drag-out, close game? Who could have predicted?
Cy Young winner Tarik Skubal plans to make 1 start for USA in World Baseball Classic; Paul Skenes available for multiple starts, knockout round
Men's basketball AP poll: Duke jumps to No. 1 after knocking off Michigan in upset weekend
The top two teams in last week's poll both lost on Saturday, something that hadn't happened in more than a year.
Analysis: Trump won’t blink on tariffs — because he can’t
It was always unthinkable that President Donald Trump would choose a new “most beautiful word” in the dictionary after the Supreme Court knocked back his emergency tariff powers.
Duke Knocks Off Top-Ranked Michigan In Neutral-Site Showdown
Duke handed No. 1 Michigan its second loss of the season in Washington D.C. on Saturday.
Saturday Pre-orders – Knock knock, it’s time to give up the bone-tithe
Check out all of today’s new pre-orders.
Olympics news, live updates: USA vs. Slovakia in men's semis; curling reaches the knockout round
Mensik upsets Sinner to reach Qatar semi-finals
Jakub Mensik prevents Jannik Sinner from reaching another final as he knocks the world number two out of the Qatar Open quarter-finals, while Carlos Alcaraz reaches semis.
Candelino scores 17, Lipscomb knocks off Bellarmine 75-72
LOUISVILLE, Ky. (AP) Ross Candelino scored 17 points as Lipscomb beat Bellarmine 75-72 on Wednesday.
Ohio State upends No. 24 Wisconsin 86-69
COLUMBUS, Ohio (AP) Bruce Thornton scored 27 points and Devin Royal added 25 for Ohio State as the Buckeyes knocked off No. 24 Wisconsin 86-69 Tuesday night.
Lewis, Villanova defeat Xavier 92-89 in OT
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Benfica vs Real Madrid delayed for 10 minutes after Vinicius Jr incident with Gianluca Prestianni
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Wardley vs. Dubois Title Fight Set For May 9
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U.S. stays unbeaten, is No. 2 seed for knockouts
Auston Matthews scored twice and set up Zach Werenski's goal with a textbook pass, Connor Hellebuyck stopped 23 of the 24 shots he faced and the U.S. defeated Germany 5-1 on Sunday night to finish group play at the Olympics unbeaten.
Olympics news, live updates: Ilia Malinin goes for gold, while Team USA women's hockey enters knockout round
Booth's 25 help Samford knock off Wofford 97-80
BIRMINGHAM, Ala. (AP) Jadin Booth had 25 points in Samford's 97-80 victory over Wofford on Wednesday.
Spring Training open thread: February 11
Well, nobody went on the 60-Day IL today so I’d consider that a success! The night is still young so I’m definitely knocking on wood here but hopefully we’re past the bad injury luck for the time being. That clubhouse needs it and the fanbase needs it as well. Phew. Anyways, here’s a random clip. […]
Archer Music Hall to offer different kind of entertainment, and hopes for a knockout
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Hims & Hers responds to FDA pressure, pulls knockoff Wegovy drug launch after regulatory threats
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Rudovskii scores 16, Bryant knocks off Maine 73-67
SMITHFIELD, R.I. (AP) Timofei Rudovskii scored 16 points as Bryant beat Maine 73-67 on Saturday.
Highlights! Figueroa Knocks Out Ball In Final Round!
Nick Ball and Brandon Figueroa went to war earlier today (Sat., Feb. 8, 2026) in Liverpool, England for Ball’s WBA Featherweight title in what was an absolute back-and-forth affair. Going into the twelfth and final round, the scores were very tight and it was anyone’s fight to win at that point. But just five seconds […]
Health Agency Refers Knockoff GLP-1 Provider Hims & Hers to Justice Department
The FDA said it would take “decisive steps” to restrict nonapproved drugs that use GLP-1 active pharmaceutical ingredients.
Edmead scores 23 as Hofstra knocks off Northeastern 80-63
HEMPSTEAD, N.Y. (AP) Preston Edmead had 23 points in Hofstra's 80-63 victory against Northeastern on Thursday.
Dorries' 21, Spadone's game-winner lead Bucknell over American
WASHINGTON (AP) — Amon Dorries scored 21 points to lead Bucknell and Achile Spadone knocked down the game-winning 3-pointer with one second remaining as the Bison took down American 60-59 on Wednesday.
UFC 325 Highlights: Mauricio Ruffy Knocks Out Rafael Fiziev
Lightweights Mauricio Ruffy and Rafael Fiziev collided on Saturday's UFC 325 main card in Sydney, Australia and the bout didn't disappoint. Fiziev took the fight to Ruffy, pressuring the Brazilian and saw success in the opening round. Late in the second frame, Ruffy connected with a right hand that ...
Hinton scores 26 as Harvard knocks off Yale 67-65
NEW HAVEN, Conn. (AP) Robert Hinton had 26 points in Harvard's 67-65 victory against Yale on Saturday.
Whitlock leads Lehigh to 77-76 OT victory against Colgate
BETHLEHEM, Pa. (AP) Nasir Whitlock scored 32 points to lead Lehigh, including the game-winning jump shot with about a second remaining in overtime, and the Mountain Hawks knocked off Colgate 77-76 on Saturday.
Davis' 24 help Hofstra knock off Monmouth 73-57
WEST LONG BRANCH, N.J. (AP) Cruz Davis had 24 points in Hofstra's 73-57 victory against Monmouth on Saturday.
South Dakota knocks off Oral Roberts 77-69
VERMILLION, S.D. (AP) — Uzziah Buntyn had 26 points in South Dakota's 77-69 win over Oral Roberts on Thursday.
Williams has 21, Lindenwood knocks off Southern Indiana 73-60
EVANSVILLE, Ind. (AP) Dontrez Williams' 21 points helped Lindenwood defeat Southern Indiana 73-60 on Thursday night.
Mercyhurst knocks off New Haven 70-51
ERIE, Pa. (AP) Mykolas Ivanauskas' 14 points and nine rebounds helped Mercyhurst defeat New Haven 70-51 on Thursday night.
Dataminers claim Yakuza Kiwami 3's ending has been changed, with a considerable knock-on effect on the rest of the franchise
Dataminers believe they've found evidence that Ryu Ga Gotoku Studio has changed the ending to Yakuza 3 in the upcoming …
FYI BR: French cinema on LPB and 100 Strong Baton Rouge nonprofits
Knock Knock Children’s Museum’s I Have A Dream Day
No. 11 Illinois outlasts No. 4 Purdue, as Keaton Wagler sets program's freshman scoring record with 46 points
The first-year guard knocked down nine 3s, the most in single-game program history.
Keaton Wagler erupts for 46 points as No. 11 Illinois outlasts No. 4 Purdue
The freshman guard knocked down 9-of-11 attempts from beyond the arc.
Gittens scores 19, Sacred Heart knocks off Niagara 71-70
FAIRFIELD, Conn. (AP) Dashon Gittens' 19 points helped Sacred Heart defeat Niagara 71-70 on Saturday.
Lindenwood knocks off Tennessee Tech 89-68
SAINT CHARLES, Mo. (AP) Anias Futrell scored 25 points as Lindenwood beat Tennessee Tech 89-68 on Thursday night.
Free update for Mario Kart World lets you race as a team in Knockout Tour
Available now. Only for the Nintendo Switch 2 system.
Donovan Dent and Tyler Bilodeau lead UCLA to stunning upset of No. 4 Purdue
Donovan Dent played his best game as a Bruin and Tyler Bilodeau knocked down the game winner, helping UCLA upset No. 4 Purdue Tuesday night.
Champions League results: Bodø/Glimt shocks Manchester City; Arsenal secures knockout phase place
Millennial generation knocking early in Texas Senate race, trying to push out Boomers
Millennial Senate candidates giving up safe seats to challenge Boomers for higher office.
Away tie for Ospreys after loss to Montpellier
Ospreys will face an away tie in the Challenge Cup knockout stages in April after a 31-26 defeat by Montpellier in Bridgend.
4 Takeaways From the 49ers' Win Over the Eagles
The bruised-and-battered 49ers went on the road and knocked off the defending champions. Here are our takeaways.
FA Cup: Macclesfield make history on emotional day
Non-league Macclesfield made FA Cup history by knocking out holders Crystal Palace on a memorable but emotional day - their victory achieved against a backdrop of tragedy.