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How Is Warner Bros. Discovery's Stock Performance Compared to Other Entertainment Stocks
Warner Bros. Discovery has rallied other entertainment stocks, yet analysts remain skeptical about the stock’s outlook.
Clark calls for more discipline from Hartlepool
Hartlepool United are on a run of five losses in six league games, and have had players sent off in three of those defeats.
Survey: CT businesses remain profitable, but rising costs cloud economic outlook
CT businesses remain profitable, but rising healthcare, energy and labor costs are weighing on their economic outlook.
How Is Live Nation Entertainment’s Stock Performance Compared to Other Entertainment Stocks
Live Nation Entertainment has considerably outperformed its sector peers recently, and analysts remain highly optimistic about the stock’s prospects.
Henderson 'gets the best out of us'
Crystal Palace midfielder Adam Wharton has said goalkeeper Dean Henderson signing a new deal is "great news for the club". Henderson, 29, has made 119 appearances since arriving at Selhurst Park from Manchester United in August 2023 and signed a new deal with the club until 2030 on Wednesday. Wharton has won the FA Cup, Conference League and Community Shield alongside his fellow England international since his own arrival in the winter of 2024, and has praised the Palace captain's presence in the dressing room.
Team effort puts Galo trio top of the scoring charts
Galo has three of its main attacking players at the top of the scoring charts this season. And on the night Atlético needed its forwards the most, Cuello, Reinier, and Bernard stepped up to score the...
What Does the Science of Climate Change Really Look Like?
Editor’s Note: This is the second in a three-part series on how the Right should think about environmental and climate policy. Read Chris Barnard on Reclaiming Environmental Policy from the Left. More than a decade ago, the world’s governments negotiated and signed the Paris Climate Agreement, committing to hold global warming well below 2 degrees Celsius. In the following years, climate had immense cultural power. Greta Thunberg emerged. Fortune 500 companies established net-zero plans. The U.S. got the Inflation Reduction Act. Then the pendulum swung back. President Donald Trump returned to the Oval Office, speaking of green energy as a “scam” and carbon footprints as a “hoax” and on all matters of international policy emphasizing bilateral engagement and power over globalism and cooperation. The technology companies that had been at the forefront of net-zero pledges and green leadership discovered the importance of all-of-the-above power to their visions for artificial intelligence and began quietly postponing or removing their targets. On the left side of the political spectrum, rising concerns about inflation and cost pushed climate lower down in the stated priorities of voters and stump speeches of politicians. The moment is ripe for a reset on the politics of climate change and for conservatives especially to chart a course that acknowledges and addresses the real challenges in plausible ways. So what should we think about climate change as we enter a post-peak climate era? If it is neither an apocalypse nor a hoax, what will hold up as a durable view of climate change? And how does it project onto the concerns and priorities of the right-of-center’s emerging coalition? New to Commonplace_? Subscribe below to get the magazine in your inbox._ Subscribe A Solid Foundation As the politics and economics of climate careened over the past ten years, the physics carried on regardless. In 2015, the year the Paris Climate Agreement was adopted, the world emitted 41.2 gigatonnes of carbon dioxide. By 2025, emissions had risen only 2.4%, to 42.2 gigatonnes, because falling emissions from land use offset increasing emissions from fossil fuels. But slow growth in annual emissions is not rapid decline, let alone net-zero, so carbon dioxide kept accumulating in the atmosphere, going from 399 to 426 parts per million. Global temperature kept rising too, from about 1.1 degrees Celsius above the 1850–1900 average in 2015, to 1.4 degrees above it in 2025. None of this should surprise anyone. Even most prominent skeptics, like the authors of the 2025 report commissioned by the Trump administration’s Department of Energy, accept the basic physics. Carbon dioxide added to the atmosphere at industrial volumes accumulates and traps heat that would otherwise escape to space. That heat warms the upper ocean and increases temperatures at the surface. Increased ocean heat and melting of land ice cause sea levels to rise. Changes in the climate become noticeable to us as subtle shifts in temperature and precipitation, seasons arriving early or late, changes in the surrounding ecosystem, and weather extremes. The much more meaningful debate is not about whether these things are happening, but about what it all means for human societies. (While it is a proxy measure of overall risk, no one experiences global surface temperature.) This debate invokes at least three interesting questions: how much today’s warming is showing up in regional climate trends, how much more warming we should anticipate, and how extreme weather events can be understood in the context of climate change. Recent scientific advances give us new insights into each of these, but there is still much to learn. This is the context in which the next generation of conservative leaders will be the first to deal with significant climate change as a fact, not a forecast. It will be with them for their entire careers. Our evolving scientific picture of climate change will come from weather and climate records stretching further into the past, new kinds of observations in the present, better modeling tools for the future, and simply more time to observe the emergence of climate signals and their tangible effects on ecosystems and communities in the United States and around the world. The policy landscape will be shaped by not only the impacts of changes in the climate, but also by the ways in which societies respond and by the emergence of new technologies for both altering the trajectory of emissions and adapting to new climate realities. Global climate records now show the fingerprints of warming in different phenomena around much of the world. The IPCC, in its most recent assessment report, documents warming trends over all land regions, even as natural variability adds substantial variance to local trends. And the highest temperature extremes have become more intense and frequent, almost everywhere, since the 1950s. Scientists are highly confident that these changes are attributable to human influence. But confidence in detecting trends and attributing them to human influence degrades across heavy precipitation events; drought trends are heterogeneous and not attributable to human activity with great confidence. For hurricanes, tornadoes, and other severe storms there is even less confidence in trends or their relationship to climate change. In general, a fair summary of the evidence is that for well-observed phenomena, like surface temperature or heavy rainfall, with a clear relationship to warming, our multidecadal observations are consistent with human influence overcoming natural variability over long time periods and extremes increasing. For regions that are sampled more sparsely, or phenomena with a higher noise-to-signal ratio, we will need to observe them longer to understand the magnitude of the climate signal or improve dynamical understanding using models and observations together. But for Climate For those who can’t wait, we also have new techniques that attempt to understand the role climate change has in influencing particular extreme events. When the climate is changing and disaster strikes, it is natural to ask whether that disaster was somehow “caused” by climate change. For scientists and policymakers acting in good faith, answering that question helps develop a more accurate picture of the problem, how it may be getting worse, and what preparations we should be making to respond to it. It may, at some point, give some weight to how liability is assigned by courts or adaptation funding is distributed by society. But how we ask this question is extremely important. It is easy to get the analysis wrong by discounting the role that meteorology plays. As meteorologist Theodore Shepherd explained in a clear 2016 review of climate attribution methods, “if a weather or climate event is truly extreme in the present climate, then perforce it requires unusual meteorological conditions, which means that climate change is at most a contributing factor.” Share Scientists have two ways to probe climate as a contributing factor, both of which have entered media coverage of extreme weather events. One asks a probabilistic question: How much more likely is a particular event (e.g., a temperature record over a particular area) amid global warming? The answer involves using historical records and computer simulations to estimate the likelihood of such an event in both a changed and a preindustrial climate. The findings are less about the specific event, and more about events of that nature. The other question is: How has the changed climate affected the specific event in question? Here, scientists try to understand what a similar event would have looked like in the preindustrial climate. This is sometimes called the storyline approach, where the story is the specific meteorological details of the event. These methods offer ways to test the intuition of scientists about real weather extremes. In late June and early July of 2021, a persistent high-pressure ridge, or heat dome, set up over the Pacific Northwest and an extraordinary heat wave affected the area from Oregon to British Columbia. For six days, it shattered temperature records across the region and hundreds died from heat-related causes, in an area where such high, and persistently high, temperatures were well outside of experience and many live without air conditioning. Scientists have studied its connection to climate change using multiple approaches. This specific event was created by a rare combination of meteorological factors, a strong high-pressure ridge created the conditions for extreme heat, which occurred on top of higher average temperatures in the region from global warming. Probabilistic analyses showed that climate change increased the likelihood of such an event by at least 8-fold to more than 100-fold. One standout example found that such an event had effectively zero probability of occurring in the preindustrial climate. The enormous range in these assessments reflects how hard it is to estimate probabilities of events at the tail of the historical record. Estimates of the effect on the temperature of the event are more clustered. A recent review paper documents how multiple methodologies have found a positive influence, roughly 1-2 degrees Celsius of an anomaly that exceeded 15 degrees, of climate change on the temperature magnitude of the event. Multiple studies have investigated and found some positive influence of climate change in other extreme events. Attribution studies found climate likely increased the heavy rainfall that accompanied Hurricane Helene in North Carolina and surrounding regions in 2024. The extensive fires that struck Los Angeles in 2025 illustrate how the causal chain can become messy, though. Studies do detect a positive influence of climate on the event’s likelihood, but while climate change likely contributed to underlying aridity, it would not have played a role in the heavy winds or land practices that preceded disaster. These event attribution studies will become more common for extreme, or damaging, weather events. They can be produced quickly, and often are reported before peer review. As the Pacific Northwest heatwave example shows, when multiple methods converge on a positive attribution, the finding should probably carry some weight even if you have to be careful about accepting the results from a single study. I expect that as climate change proceeds and the climate thus departs further from a preindustrial counterfactual, the influence will become more detectable across a variety of extreme events and more easily identified. This will be used to cast blame, but can also be used to inform how communities and society adapt to ongoing change. We May Still Be Surprised One positive development, insofar as less climate change is better, has been that our central estimates for future climate change should probably be revised downward. Mostly, that is because the high-end warmings that scientists regularly analyzed about ten to 20 years ago, driven by high emissions throughout the twenty-first century, now appear to be somewhere between unlikely and impossible. At one time, the upper end of mainstream climate projections extended well into 4 to 6 degrees Celsius of warming by the end of this century, which, models suggest, would have wrought enormous real-world damage. Current energy and policy trends now point toward 2.5 or 3 degrees. Damages and risks are commonly modeled as increasing steeply with more warming, so this is already a better-than-previously-expected outcome for the climate (which is independent of the physical response to emissions). But we should maintain a wide range for plausible outcomes and prepare for the possibility of being surprised. Emissions trajectories are subject to deep uncertainty, the physical climate response is still developing, and whatever change occurs in the climate will then be mediated through unpredictable economic, social, and political institutions. Over the past decade, the pace of warming surprised some keen observers and appeared to accelerate, though not yet outside the range of expectation provided by climate models. The reasons for that apparent acceleration are being actively studied (as was the apparent pause in warming from 1998 to 2012), but no single driver has emerged. Some blame it on the El Niño, variability which would have no bearing on climate. Some think it is a result of factories in East Asia and global shipping fleets cutting aerosol emissions, which in the strongest version of the argument would indicate higher climate sensitivity to carbon-dioxide emissions. Others are more measured, not yet ready to draw solid conclusions as to whether climate projections require revision. We will have to see. Long-Term Thinking Climate change asks us to think over long time scales. But the pace of human-driven warming is compressing a large global change into a century. Changing weather patterns and extreme events are already causing adjustment costs and damages and will do more. Adaptation will help, but it is not free. For some communities, these costs will erode livelihoods and well-being, and may force migration. Are we prepared for large-scale managed retreats in the United States? Thankfully, American wealth, geographical diversity, and moderate climates may leave us better prepared than many around the world. But wealthy countries can still suffer serious disruption from narrowly concentrated costs, even if they appear entirely manageable in aggregate. Readers of Commonplace are familiar with the challenges of rapidly adapting to economic forces. The displacement that came from the China Shock is barely perceptible in aggregate GDP and employment data, but it affected millions of people and those people were far less mobile than economic models tended to assume. Deindustrialization rippled through the nation with enormous effects for not only our economic vitality, but also our national security. The forces surrounding climate change may not be so different; the world gets richer and must accept some diffuse costs. Those may be modest overall, but cause all manner of unpredictable effects with which policymakers must cope. In the case of the China Shock, our faith in a growing pie served us poorly. We’ll need to do better on climate. Leave a comment
Vikings place RB Jordan Mason on IR with fractured thumb
Mason is listed as a co-starter on Minnesota’s depth chart and splits backfield duties Aaron Jones. He led the Vikings with 15 carries for 59 yards in Sunday’s win over the Green Bay Packers.
Fake MyChart messages target seniors’ personal, financial information
Keep your audience informed about the MyChart scam that targets seniors with fake Medicare offers and phishing attempts.
Oracle Health extends clinical AI agent to inpatient nurses
Oracle Health is building out its generative AI capabilities for inpatient nursing workflows. The company announced the U.S. | The clinical AI agent, embedded directly within the Oracle Health Foundation EHR, combines voice-driven chart navigation and search, acute nursing summaries and voice-enabled discrete charting.
Disney's Live Action 'Moana' Bows No. 1 on Weekly U.K. Home Entertainment Sales Chart Through Sept. 16
Disney’s live-action Moana debuted No. 1 on the Official Chart, the U.K.’s weekly home entertainment sales chart through Sept. 16. Starring Dwayne Johnson and Catherine Laga’aia, the movie generated $321.9 million at the global box office before hitting digital retail channels on Sept. 8. The title supplanted the three-week No. 1 run for Disney’s Toy … Continue reading "Disney’s Live Action ‘Moana’ Bows No. 1 on Weekly U.K. Home Entertainment Sales Chart Through Sept. 16"
From PA charter student named Doctor of Medical Science program director
Campbell University’s College of Pharmacy & Health Sciences has named Ashley Nordan, DMSc, MHPE, MSCR, PA-C, program director of its… More on this post
Stamford industrial manufacturer to acquire water pump business for $240M
Stamford-based Crane Co. plans a $240 million water pump acquisition, adding a business expected to generate $115 million in 2026 revenue.
70-82: Chart
Mariners 1, Anaheim 2 A tisket, a tasket: The bullpen, +0.07 I lost my yellow basket: Cole Young, -0.23 WPA Game Thread Comment of the Day
Eagles Make Head-Scratching Decision Behind Saquon Barkley
All offseason long, the Philadelphia Eagles have generated a ton of hype for their second-string running back, Tank Bigsby. Although Saquon Barkley is the clear-cut No. 1 back on the depth chart, the expectation was that Bigsby would get some more work this season, which would help Barkley save some miles. After seeing Week 1 […] The post Eagles Make Head-Scratching Decision Behind Saquon Barkley appeared first on HEAVY.
Maryland football’s Malik Washington shrugs off Virginia Tech criticism
COLLEGE PARK — Malik Washington refused to take the victory lap. After an uneven showing in Maryland’s season-opening 62-0 pasting of Hampton on Sept. 5, the sophomore quarterback reminded fans and opponents of what he is capable of by passing for 347 yards and two touchdowns in Saturday’s 38-14 victory over UConn at Rentschler Field in East Hartford, Connecticut. That performance was a ...
Jaffrey couple cut energy costs with NHSaves
Evan Clements and Precia Harthcock of Jaffrey love their 1926 home, but they acknowledge the drawbacks of houses built in that era. The room that is now their sitting room, for example, was once a porch that had been enclosed and is noticeably colder than other parts of the house. The second floor was much hotter than the first floor, and their kitchen was drafty.
Tuesday Scaling the Rockies: Hartford Yard Goats begin playoffs tonight
Colorado Rockies news and links for Tuesday, September 15, 2026
Halloween: The Game scores one of the biggest Xbox launches of 2026 so far
Halloween: The Game debuted at #24 on the Xbox Top 40 Chart, making this online multiplayer horror game one of the biggest premium Xbox launch titles of 2026.
Local entrepreneur bets on New Orleans, opens new bank amid a wave of consolidations
He's spent his career running McDonald's locations and now he's opening the first new bank charter in New Orleans in 16 years. Here's how it happened.
Evaluating DeVonta Smith as WR1
Though he has been a number one receiver before in his career, this past Sunday was DeVonta Smith's debut as the top receiver on the depth chart in the
Will Netflix’s Latest Horror Film Save Its Summer? And Introducing a New Data Source...
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) All month, I’ve been polling you, my readers, on how we think the summer’s biggest blockbusters will do when they eventually land on streaming, and I wanted to share the results. First up, how readers think The Odyssey will perform when it comes to Peacock... People are pretty bullish that The Odyssey will smash it for Peacock. I don’t know that it will have as much rewatchability as Wicked did for kids, but we’ll see. It is now Universal’s highest-grossing film of all time. One note: almost half of Christopher Nolan’s films weren’t available for streaming the week The Odyssey came to theaters, including some of his biggest films like Inception, Dunkirk, Tenet, Oppenheimer and Insomnia. If you did want to watch the others, Prime Video had Memento and The Dark Knight trilogy, HBO Max only had The Dark Knight trilogy (even though Warner Bros. produced most of Nolan’s films), Hulu had The Prestige and Interstellar, and Paramount+ had Interstellar. So you needed at least two streaming subscriptions to catch the rest. Warner Bros. whiffed right here. I know they have long term licensing deals, but they should have tried to get as many Nolan films on HBO Max for launch as possible. Here are the results for Spider-Man: Brand New Day: The audience is a bit more mixed on this one, with everyone agreeing Spider-Man will swing to a big opening, but not necessarily elite or best all time. On to this week’s issue. Netflix continues searching for a hit straight-to-streaming summer film and Lioness and Ted Lasso allow me to look at the difference between a “hit” and a ‘hit for them”. All that, plus new YA/teen melodramas on Prime Video and Netflix, the House of the Dragon finale, USA Network claims a big opening, more big NFL ratings, all the flops, bombs and misses, and a whole lot more. But we start with a fun new data announcement. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of August 3rd to August 9th, 2026. You can find a link to my terminology here.) Subscribe A New Data Source: Reelgood’s Data on Content Libraries Here’s a fun new treat for you. Reelgood—an online service and app that lets users track where shows or films are streaming—is providing data every month for the Streaming Ratings Report on the size of each streamer’s catalogue, along with the new shows and films for each streamer. Yay! Previously, I had pulled “new shows on streamers premiering on the first of the month”: While I liked that data cut, it was a big wonky since it didn’t show all of the new shows or movies that came to a streamer each month. Instead, I would have preferred something like this from Reelgood’s annual report: And now we have it! I’m going to feature Reelgood’s data monthly, showing both total catalogue size and new shows and films appearing on the charts. That’s going to make these two cool new charts. First, here’s the size of various streamers’ film catalogues… (By the way, Reelgood offered to make the charts for me, but I like doing that task by hand to understand the data better.) They also provided data back to last year. Here’s the number of films timeline: And here are the new films on each streamer for the month prior to Aug: As I get used to this data, I plan to keep tinkering with how I display it, but I’m excited to feature it monthly. Today, I’m sharing the film charts; next issue, I’m going to feature TV shows by streamer. Now, in full disclosure, Reelgood is a sponsor of this little-newsletter-that-could. But in my constant quest to figure out what streamer various shows and films are on, I was already a Reelgood user before this sponsorship. I go to their website all the time, and their data is very accurate on where shows are (or have been). Plus, I’ve been sharing their weekly top ten lists for years now, pre-sponsorship. For me, this is a great win-win, since I get to amplify a service I love, and I get a cool new data source to play with. Now, normally folks don’t usually mention their sponsors directly, but as I wrote before, as I start featuring ads in my newsletter, I plan to be extremely open about who is sponsoring my writing so you can trust what I write. Television - Two Big Returning Shows Look Set to Take Over The Charts One key question when it comes to judging streaming shows is whether a show is a “hit” or a “hit for them”. To be clear, the former means a show that’s one of the top shows on streaming, no questions asked. The latter means a show is one of the biggest, for a given streamer. That distinction makes a big difference! It’s really good to be one of the biggest shows on a streamer; it’s much better to be the biggest on streaming, despite the size of a streamer. Because, as we’ve seen now, nearly every streamer—while lacking the number of subscribers or usage of Netflix—can make hit TV shows: Paramount released Landman, whose first and second seasons were among the top two TV shows the year they came out. HBO Max’s The Pitt’s second season is the biggest show of the year so far. Love Island USA was the top show in 2025 for Peacock. And, crucially for today’s discussion: Wayyyyyyyyyyyyyyyyyyyyyyyyyy back in 2023, Ted Lasso was actually the top streaming show of the year according to Nielsen! So even Apple TV (formerly +) can make hit shows. It just doesn’t make them that often. And looking at the Nielsen charts this week, we have two prime candidates for this discussion: That’s right: Ted Lasso returned to Apple TV for its fourth season. Did it return in all its expected glory? Sure, though right now it’s still just a “hit for Apple TV”, but we’ll see how long it lasts on the charts. Its ten episodes are coming out weekly. (Smart choice, Apple!) Ted Lasso started out strong, actually making the Nielsen charts the week before new episodes dropped, which is a rare feat. (Shows like Stranger Things or Bridgerton have pulled that off. That’s terrific company to join!) On Nielsen, it opened to 14.4 million hours in its first week, and 16.6 million the week of 10-Aug. Here’s how that compares to previous seasons: Apple put out that this is their biggest TV launch through two days ever, and looking at the chart and Apple TV’s viewership history, I’d believe it. Here’s Apple’s top shows for season two and beyond: Other data tells a (mostly) similar story. Ted Lasso made Samba TV and it has elite IMDb scores, an insane 8.7 on 465K reviews. The only outlier is Luminate, where the latest season only had 7.4 million hours, and no other seasons made the top ten. As you’ll see below, that’s well below some other solid, but not spectacular shows like Sterling Point, Ride or Die or Furious. I’d be surprised if Ted Lasso isn’t bigger than those other shows, but it’s fine for different data sources to occasionally disagree. And while it’s sucky to bring this up, given that Warner Bros. produced this show, I do wonder how the streaming wars may have been different if Ted Lasso landed on HBO Max initially instead of Apple. I don’t think one show can make or break a streamer, but given HBO’s brand, it could have helped bring people to that streamer much earlier in its lifespan. (Though yeah, I don’t love calling out executives for passing on hit shows, since that’s just the nature of the job. Even the absolute best execs will pass on lots of successful shows. The key is not greenlighting the under-performers/misses.) The other show I’m thinking about in the “hit or hit for them” category is Lioness from Paramount+. Like Ted Lasso, its first season missed the charts, but it’s grown its audience since then. Here’s how season three opened: We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How Lioness did on streaming... Two new melodramas for Netflix and Prime Video... Whether Netflix’s latest horror film saved its summer... Hulu’s Furious and Prime Video’s Ride or Die continuing their strong runs... The latest high profile showrunner to flop on streaming... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. Next week, we’ve got a double issue—since the week of 17-Aug had very few notable new shows or films—so I’ll look at HBO’s Lanterns, Prime Video’s Reacher, Netflix’s Tires, Outer Banks (which posted up huge numbers four years ago), an Aussie romance, and another baseball event (that didn’t resonate). And a bunch of movies like the latest dramedy from an Adam Sandler daughter, Don’t Say Good Luck, Camp Rock 3 on Disney Channel and Disney+, Michael on Starz, and more. Later this month, we’ve got a ton of shows and films to analyze! Movies will be the big story, featuring a box office bomb (Supergirl on HBO Max) and an “underperformer” (The Mandalorian and Grogu on Disney+) contending with a bunch of star-studded straight-to-streaming films like Netflix’s The Whisper Man (Adam Scott, Michelle Monaghan and De Niro!), Mayday on Apple TV+ (Ryan Reynolds and Kenneth Branagh!), The Runner (Gal Gadot) and The Last Sunrise (Eva Longoria and Maia Reficco) on Prime Video. Plus, a ton of TV shows have sophomore seasons coming out. Will The Gentleman put up big numbers on Netflix or suffer from a sophomore slump? Leanne and Beauty in Black on Netflix seem small, but they both might be bigger than you think. Hulu has a bunch of shows: a new season of The Secret Lives of Mormon Wives (the first after all the controversy last year) and the second season of Chad Powers (from Peyton Manning’s production company and starring Glen Powell). This one flopped last year; can it score a touchdown this year? Same goes for FX’s Adults, which I didn’t track last year; will it hit this year? Peacock’s The Office spinoff, The Paper and Apple TV’s Dark Matter also return for second seasons. And Netflix has more Untold specials featuring Vince Young, Raygun (that horrible breakdancer) and Mr. T. Long term, Paramount+ is rebooting yet another franchise, Clueless, and I’m somewhat bullish on this new show. The talent attached (Alicia Silverstone) and creative Josh Schwartz and Stephanie Savage (of The O.C. and Gossip Girl) also feel solid...if they make it funny like the original.
Marcus Freeman Pleased With The Development Of Notre Dame Underclassman
Freshman standout Jonaz Walton and a wave of emerging underclassmen are seizing their opportunities, blending elite speed with refined technique to bolster the Irish depth chart.
Wardogs Is a Massive Hit on Steam, and It’s Already on Sale for $33
Wardogs is a new online first-person shooter that has been riding high on the Steam charts since it came out on September 10. You can get it for $33 right now at Fanatical.
Please Stop Conflating Sports Betting Handle With Spending On Entertainment
Editor’s note: The Cashout for paid subscribers will publish on Tuesday. Every September there’s a huge uptick in how much people bet on sports with the start of football season. Which means it’s time to get ahead of a ridiculous narrative before it picks up steam on social media or in mainstream media. Subscribe Every few months I see some version of this: [ Charlie Bilello@charliebilello Americans bet over $165 billion on sports last year, which is more than they spent on movies, books, concerts and sports tickets - combined. 1:00 PM · Jun 28, 2026 · 4.1M Views 258 Replies · 674 Reposts · 4.23K Likes ](https://x.com/charliebilello/status/2071217050328895935?s=20) Fortune published this in July. The headline and start of the story tell the same narrative (emphasis added): Gambling becomes America’s favorite pastime as Americans spend more on sports bets than movies, arts, museums, and music combined: The North American box office totaled $8.87 billion in 2025, which is still 22% below pre-pandemic levels. Recorded music revenue hit a record $11.5 billion. Live music like concerts and festivals brought in $18.51 billion. Meanwhile, book publishers tracked by the Association of American Publishers reported $14.6 billion for the year. And the U.S. museum industry generated an estimated $16.4 billion. Add it up and the total comes to roughly $70 billion, which is less than half what Americans wagered on sports. The story, to its credit, goes on to tell us why sports betting is entirely different, although people who only read headlines will miss that nuance. (The tweet above definitely skips over the nuance.) I will mostly be preaching to the choir here, but it’s worth saying out loud: Wagering money on sports is not the same thing as spending on entertainment from a financial perspective. When you spend money on a movie or concert ticket, that money is gone. You exchanged money for an experience. It’s a good trade! I get to have fun for “x” dollars. (Unless the movie sucks, I guess.) When you bet money on sports, the money is not necessarily gone every time you wager it. It could be gone, but sometimes it’s not and you actually get more money back! That’s not “spending” money or something you should try to compare directly to entertainment spend. A far better comp would be how much people lose at sports betting. That number was more like $17 billion in the US last year, at least for state-regulated sportsbooks. Why are we trying to equate handle and entertainment spending? I dunno. It makes for splashy headlines, I guess. Now, people should be betting for entertainment, and not because they expect to win in the long term; no doubt about it. Anyway, here’s hoping I don’t see people saying Americans “spent” hundreds of millions of dollars on sports betting this fall. Mindway AI and DraftKings Expand Responsible Gaming Drive with Launch of Gamalyze American Football In time for the NFL kickoff, Mindway AI has expanded its partnership with DraftKings to launch Gamalyze American Football the second title in the neuroscience-based Gamalyze Sports collection. Following the success of Gamalyze Football (soccer) during the FIFA World Cup, this gridiron-themed update replaces static questionnaires with immersive, stadium-inspired gameplay. Backed by 10+ years of Aarhus University research, Gamalyze evaluates real-time decision-making to deliver instant, unbiased player risk assessments. Integrated into DraftKings’ platform and nationwide activations, it engages fans when excitement peaks. Ready to upgrade your player protection? Contact Mindway AI to try Gamalyze Sports today. Gambling news roundup 🚨The important stuff 1st NFL Sunday of Season ‘Champagne-Popping Day for Bettors’ (Covers): “The first NFL Sunday of the season was a champagne-popping day for bettors, while the book was left cleaning up the corks,” Caesars’ head of football Joey Feazel said prior to the Sunday night game. “Caesars Sportsbook reported that Detroit’s Jahmyr Gibbs, Baltimore’s Derrick Henry, Indianapolis’ Jonathan Taylor, and Atlanta’s Bijan Robinson were among the top five most-bet players to reach the end zone, and all of them cashed tickets.” [ Ben Fawkes@BFawkes22 A @CaesarsSports oddsmaker on how Week 1 has gone so far: “The first NFL Sunday of the season was a champagne-popping day for bettors, while the book was left cleaning up the corks.” ➡️8 of 10 most popular anytime TD scorers cashed 1:31 AM · Sep 14, 2026 · 276K Views 16 Replies · 16 Reposts · 615 Likes ](https://x.com/BFawkes22/status/2099310001927995849?s=20) 🔍 Are we already getting a “customer-friendly results” narrative in Week 1? NFL Commissioner Roger Goodell spoke with CNBC about the prediction markets industry: “We think that there needs to be stronger regulations into the predictive markets,” Goodell said. “We want to see that to protect the integrity of our game. We want to make sure we’re protecting the consumers that are on those platforms for the NFL. So, we’re continuing to have conversations with them and talk to them about the things that we think they need to do to strengthen that so that they could be potential partners at some point in the future.” More on the NFL + PMs: [ Straight to the Point Quid Pro Quo The NFL has asked Kalshi and other prediction markets to remove certain easy to manipulate markets. Does a potential partnership hang in the balance… Read more 6 hours ago · 19 likes · Steve Ruddock ](https://straighttothepoint.substack.com/p/quid-pro-quo?utm_source=substack&utm_campaign=post_embed&utm_medium=web&embedding_publication_id=1472492) Kalshi was on my podcast?: Kalshi was on my podcast [ The Event Horizon Episode 32: Talking Prediction Market Enforcement With Kalshi’s Robert DeNault Kalshi? On my podcast? Yep… Listen now 5 hours ago · 6 likes · 1 comment · Dustin Gouker ](https://nexteventhorizon.substack.com/p/episode-32-talking-prediction-market-enforcement-kalshi?utm_source=substack&utm_campaign=post_embed&utm_medium=web&embedding_publication_id=1472492) DraftKings Enhances Responsible Engagement Efforts With New Customer Initiatives, Tools and Education (press release): DraftKings Inc. today announced a series of new initiatives designed to promote responsible engagement and increase awareness and use of the tools and resources to help customers make informed decisions and engage responsibly. The efforts include a new digital advertising campaign featuring Kevin Hart and Nick Jonas that promotes responsible engagement, a PGA TOUR sweepstakes that promotes customer engagement with responsible engagement features, the launch of Gamalyze American Football in collaboration with Mindway AI, and new custom cool-off options that give customers enhanced flexibility when choosing a cool-off period. The initiatives build on DraftKings’ commitment to making responsible engagement an integral part of the customer experience and providing players with accessible tools and resources that help them make informed choices about their gaming experience. “At DraftKings, responsible engagement is embedded in how we operate and is essential to building trust with our customers and our long-term sustainability,” said Lori Kalani, Chief Responsible Gaming Officer at DraftKings. “We’ve continued to invest in tools and resources that give customers enhanced access to information about their play and more choices for managing how they engage. From My Budget Builder and My Stat Sheet to player-set limits and new custom cool-offs, we’re continuing to evolve our approach while promoting awareness and use of the tools and resources available to help customers play responsibly.” … DraftKings is launching a new digital advertising campaign featuring Kevin Hart and Nick Jonas that continues the pair’s road trip and promotes responsible engagement and awareness of the tools and resources available to help customers make informed choices about their gaming experience and engage responsibly. The campaign was initially launched on Sep. 10th and will reach customers through digital channels, bringing responsible engagement messaging to fans in an engaging way. bet365 Launches “The Matchup,” a New Weekly Video Podcast Hosted by Super Bowl Champions Chris Harris Jr. and Emmanuel Sanders (press release): "bet365, a global leader in online sports betting and gaming, today announced the launch of “The Matchup,” a new weekly video podcast hosted by former Super Bowl Champions Chris Harris Jr. and Emmanuel Sanders. Featuring current and former NFL players, the original series marks a significant, intentional investment in football as bet365 works to become a go-to destination for U.S. bettors throughout the season. “The Matchup” premieres September 10, with new episodes released weekly in both video and audio formats. Full episodes will be available on YouTube, Apple Podcasts, Spotify and wherever podcasts are available, with clips and additional content rolling out across YouTube, X, Instagram, Facebook, Threads, and TikTok. The show is being produced by Last Row Digital Media. Each week, Harris and Sanders will be joined by guests from across the game to break down the biggest NFL matchups, unpack the latest league news and share perspectives that go beyond the box score. By bringing together two former players with distinct perspectives and firsthand experience, “The Matchup” will give audiences timely context and a deeper understanding of the teams, players and storylines shaping the week ahead. “Every great football conversation starts with a matchup—who has the edge, what everyone is overlooking and what could change the game,” said Chris Harris Jr. “Emmanuel and I have experienced the game from different perspectives, and we want the audience to feel like they are part of the conversation and leave every episode knowing more about the week ahead.” Today’s iGaming companies face new litigation threats as expansive consumer protection statutes spark lawsuits with sky’s-the-limit aspirations, sometimes backed by private funders. Clients of Ifrah Law have a staunch defender in Robert Ward – an agile litigator and case tactician who responds to the changing state of play with creative legal defenses and efficient case-closing strategies. Robert draws on federal clerkship experience and appellate defense work to advise iGaming clients on litigation exposure, white-collar risk, and regulatory defense across multiple jurisdictions. Read More: Robert Ward on Helping iGaming Clients Outmaneuver Lawsuit-Obsessed Adversaries 🔮 Prediction markets Update on legal action in Connecticut: [ Daniel Wallach@WALLACHLEGAL Connecticut says gaming service license holders which received subpoenas over sports prediction markets “are not under investigation” by the @CTDCP but may possess information that could assist the state “in evaluating the conduct of prediction market platforms.” 2:31 PM · Sep 13, 2026 · 844 Views 5 Likes ](https://x.com/WALLACHLEGAL/status/2099143914271670576?s=20) American Gaming Association Opposes CFTC Bid to Block New York Prediction-Market Enforcement (DeFi Rate): “The brief points to the Ninth Circuit’s Aug. 28 decision in KalshiEX LLC v. Assad, which the AGA says supports New York’s authority to regulate sports contracts as gambling. It also cites Kalshi advertising, product comparisons and reporting on Kalshi’s sports volume to argue that the economic product resembles a sportsbook wager more than a conventional financial hedge.” [ Daniel Wallach@WALLACHLEGAL AGA intervenes in CFTC v. NY case to oppose CFTC request for preliminary injunction, says the CFTC’s arguments “obfuscate a simple truth: prediction markets offer sports betting.” Highlights CA9 decision, @DustinGouker (6x), and $1.32 billion in OSB taxes for NY (0 from PMs). Daniel Wallach @WALLACHLEGAL High stakes hearing on Monday in CFTC v. New York State. If SDNY judge Lorna Schofield denies the CFTC’s motion for preliminary injunction, the New York AG would have a clearer path for securing a state court geofencing order against Kalshi, Coinbase, and Gemini Titan. 2:08 AM · Sep 13, 2026 · 4.78K Views 1 Reply · 2 Reposts · 8 Likes ](https://x.com/WALLACHLEGAL/status/2098957043474280584?s=20) Gaming Commission remains member of gambling council after questions raised over ties to Kalshi (Mass Live): “The Massachusetts Gaming Commission will not follow the leads of gaming regulators in Ohio and Michigan and drop ties with the National Council on Problem Gambling over its new association with Kalshi.” Sponsor’s messageTrusted Voices: Conversations About Betting is designed to equip adults, including parents and coaches, with tools and resources to talk to young people about gambling, including information on warning signs, risks and proxy betting. The program is led by retired professional basketball player Randy Livingston and his wife, basketball agent Anita Smith, who share their personal stories related to problem gambling, with the hope of preventing others from experiencing similar harms. Learn more and join the conversation here. 📣 Industry news Gaming M&A: Latest Mergers, Acquisitions and Deals (SBC Americas): “But what else is happening in the world of gaming mergers, acquisitions, investments, and partnerships? Here, we round up some of the news you might have missed.” BetMGM Named Official Sports Betting and Online Casino Partner of the Minnesota Vikings in Canada (press release): BetMGM, a leading iGaming and sports betting operator, announced a multi-year partnership with the Minnesota Vikings, naming it the Official Sports Betting Partner and Online Casino Partner of the team in Canada. The agreement gives BetMGM rights to use Vikings marks across approved sports betting, online casino and marketing activities in Canada. In addition, Vikings Big Kick LuckyTap™, a casino game by Design Works Gaming, is available now exclusively at BetMGM Casino in Alberta and Ontario. “Vikings fans bring a level of passion and loyalty that extends well beyond game day,” said Matt Prevost, Chief Revenue Officer at BetMGM. “As the home of one of the largest collections of sports-themed casino content in North America, BetMGM is uniquely positioned to combine sports fandom with iGaming. We are eager to start football season off strong with another fantastic partnership especially as we expand our reach in Canada to Alberta.” Martin Nance, Minnesota Vikings Chief Marketing Officer, said, “As we continue to deepen our connection with Vikings fans across Canada, we’re proud to welcome BetMGM as the team’s official sports betting and online casino partner in Canada. Their commitment to innovation and fan engagement aligns well with our organization, and we’re excited to create memorable experiences that celebrate Vikings football and connect with Canadian fans in new and meaningful ways.” Caesars Entertainment Launches Ball Rush Jackpots™ in New Jersey,the Latest Proprietary Online Title from Empire Creative™ (press release): Caesars Entertainment, Inc. (NASDAQ: CZR) (“Caesars”) today announced the launch of Ball Rush Jackpots™, a new ball-and-peg style online casino game developed by Empire Creative™, the Company’s in-house game development studio. Now live in New Jersey across Caesars Palace Online Casino, Caesars Sportsbook & Casino and Horseshoe Online Casino, Ball Rush Jackpots is expected to become available in additional jurisdictions where Caesars offers online casino gaming following regulatory approval. The title expands Caesars’ growing portfolio of proprietary online casino titles, following the successful launch of Ca$hline™ earlier this year and further diversifying the Company’s lineup beyond traditional slots and table games. Ball Rush Jackpots follows the traditional ball-drop gameplay experience where players drop a ball down a board filled with pegs to land in a prize slot. As balls navigate independently through a field of pegs, every drop creates new opportunities to collect feature symbols, unlock bonuses and pursue jackpots, delivering a different experience with every round. “Ball Rush Jackpots delivers a different kind of casino experience for our players, combining easy-to-understand gameplay with meaningful customization, exciting bonus opportunities and jackpot potential,” said Matthew Sunderland, Senior Vice President and Chief iGaming Officer at Caesars Digital. “As we continue expanding our proprietary content portfolio, we’re focused on creating games that are simple to pick up, rewarding to revisit and designed around the features players enjoy most.” Bally’s Corporation Secures New Financing to Support the Development of the Bally’s Bronx Project (press release): Bally’s Corporation (NYSE: BALY) (“Bally’s” or the “Company”) announced today that it secured new financing led by WhiteHawk Capital Partners, LP to fund further development of the Bally’s Bronx project and general corporate purposes. The new financing comprises closing date term loan commitments in an aggregate principal amount of $400 million and delayed draw term loan commitments in an aggregate principal amount of $160 million (together, the “Facilities”). … Bally’s Chairman of the Board, Soo Kim, commented, “This important financing allows us to progress the pre-construction planning process so that we are ready to complete the remainder of the capital raise and remain on schedule. Furthermore, the additional liquidity provides us greater flexibility for other capital opportunities.” WORLD JAI ALAI LEAGUE LAUNCHES CENTENNIAL SEASON AND ENTERS NEXT CHAPTER IN MIAMI (press release): The World Jai Alai League will open its 2026 fall season on Tuesday, September 15 at Miami’s JAM Arena, beginning a milestone season that marks 100 years since professional Jai Alai first arrived in Miami. Season X, the tenth season of the Battle Court team-based competition launched in 2022, will also be the first since entrepreneur and sports asset investor Rob Gough acquired the World Jai Alai League in August 2026. The acquisition marks the beginning of a new chapter for the league. World Jai Alai League will maintain the existing Battle Court competition and operating format, with Chief Operating Officer Scott Savin overseeing Season X. Gough and his team will use the coming months to listen to players and fans, evaluate opportunities across the league, and execute plans for a broader evolution of Jai Alai’s presentation, live experience, media, marketing and commercial strategy beginning in 2027. “This is a really unique moment for Jai Alai,” said Rob Gough, Owner of the World Jai Alai League. “We have a sport with more than 100 years of history in Miami, extraordinary athletes and incredible speed, but I also believe there is enormous untapped potential.” bet365 reveals most popular online slots in 3 US states in August (SBC Americas): “In its monthly Gaming Insights and Performance report, growing online casino operator bet365 tracks player trends and game performance in online slots across its North American online casino markets.” The Closing Line is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
Albany County asking voters to replace coroners with medical examiner's office
The charter change proposal will appear on the November ballot.
Major CT marketing agency launches healthcare specialty, taps leader from local firm
The agency says CK Health is designed to help healthcare organizations navigate a rapidly changing landscape and build stronger brands.
CT launches $5M tax credit to help small businesses offer health insurance
Connecticut's ICHRA tax credit offers small businesses up to $1,000 per employee annually to help offset rising health insurance costs.
CT launches $5M tax credit to help small businesses offer health insurance
Connecticut's ICHRA tax credit offers small businesses up to $1,000 per employee annually to help offset rising health insurance costs.
CT Business Blend: Sept. 14, 2026
Hartford Business Journal’s Greg Bordonaro and WTIC’s Brian Shactman explore the people, companies and trends shaping Connecticut’s business scene every Monday at 8:30 a.m. on WTIC 1080 AM.
Middlesex Health Cancer Center receives $1M grant from Liberty Bank Foundation
Liberty Bank Foundation awarded $1M to Middlesex Health to support cancer screening, treatment technology and patient services.
NPF Selects Cerys Davies, Paighten Harkins to Attend Wharton Seminars for Business Journalists
Cerys Davies of the Los Angeles Times and Paighten Harkins of The Salt Lake Tribune won NPF's fellowships to the 2026 Wharton Seminars for Business Journalists.
Trump wants Bombardier out of U.S. market. In CT, the company employs hundreds
Trump’s Bombardier jet sales ban threat could affect the Canadian jet maker’s Connecticut workforce, aerospace partners and Bradley Airport operations.
UHart to cut $7M, boost faculty teaching loads as enrollment slides
The University of Hartford is cutting $7 million from its $187 million budget as declining undergraduate enrollment pressures revenue in West Hartford.
Physitrack Selected by US Metropolitan Healthcare System for Enterprise-Wide, Epic-Integrated Digital Rehabilitation
Three-year enterprise agreement with a total three year contract value of approximately US$78,000 (approximately EUR 67,000) in total, covering an enterprise-wide deployment and full Epic and MyChart integration.Physitrack PLC (Nasdaq First North Premier Growth Market: PTRK), a global provider of d…
70-80: Chart
A’s 8, Mariners 7 The first winds of fall: Randy Arozarena, +0.43 WPAFalling on your butt: Andrés Muñoz, -0.49 WPA Game Thread Comments of the Day Like every Mariners fan, I’ve been having a lot of feelings about Rizzs this season, but we’ll be in good hands. And a bonus GTCOD, a late entrant from […]
Eagles Shake Up Depth Chart With QB Decision
The Philadelphia Eagles shook up their depth chart with QB decision before Sunday's opener. The post Eagles Shake Up Depth Chart With QB Decision appeared first on HEAVY.
'Practical Magic 2' conjures a No. 1 box office debut with $30 million
LOS ANGELES (AP) — “Practical Magic 2" conjured a box-office victory this weekend, opening atop the North American charts nearly three decades after its predecessor grew from a modest theatrical performer into a cult favorite.
'Practical Magic 2' conjures a No. 1 box office debut with $30 million
“Practical Magic 2” conjures a box-office victory this weekend, topping the North American charts nearly three decades after its predecessor. The Warner Bros. sequel, starring Sandra Bullock and...
'Practical Magic 2' conjures a No. 1 box office debut with $30 million
“Practical Magic 2” conjures a box-office victory this weekend, topping the North American charts nearly three decades after its predecessor. The Warner Bros. sequel, starring Sandra Bullock and...
‘Practical Magic 2’ conjures a No. 1 box office debut with $30 million
“Practical Magic 2” conjures a box-office victory this weekend, topping the North American charts nearly three decades after its predecessor.
'Practical Magic 2' conjures a No. 1 box office debut with $30 million
“Practical Magic 2” conjures a box-office victory this weekend, topping the North American charts nearly three decades after its predecessor | KNX News 1070 AM
'Practical Magic 2' conjures a No. 1 box office debut with $30 million
“Practical Magic 2” conjures a box-office victory this weekend, topping the North American charts nearly three decades after its predecessor.
'Practical Magic 2' conjures a No. 1 box office debut with $30 million
“Practical Magic 2” conjures a box-office victory this weekend, topping the North American charts nearly three decades after its predecessor.
'Practical Magic 2' conjures a No. 1 box office debut with $30 million
“Practical Magic 2” conjures a box-office victory this weekend, topping the North American charts nearly three decades after its predecessor
'Practical Magic 2' conjures a No. 1 box office debut with $30 million
“Practical Magic 2” conjures a box-office victory this weekend, topping the North American charts nearly three decades after its predecessor.
'Practical Magic 2' conjures a No. 1 box office debut with $30 million
“Practical Magic 2” conjures a box-office victory this weekend, topping the North American charts nearly three decades after its predecessor.
Buffalo Bills Inactives Against Houston Texans Include Promising Rookies
Buffalo sidelines rookie receiver Skyler Bell while elevating Frank Gore Jr., reshuffling the depth chart as key injuries impact the roster for Sunday’s clash in Houston.
Arrowhead rallies to defeat Brookfield East
Arrowhead took on Brookfield East in a high school football game Friday, Sept. 11, in Hartland.
Today’s famous birthdays list for September 13, 2026 includes celebrities Tyler Perry, Lili Reinhart
Tyler Perry and Lili Reinhart share a birthday today. Check out our list of celebrities and other famous people with birthdays on September 13, 2026, see photos and find out a fun fact about each person.
Jaguars Add New QB for Week 1 vs. Browns
The Jacksonville Jaguars‘ roster on Sunday will include a quarterback who wasn’t on the active roster a few days ago. He’s a familiar face, though, as the Jags make sense of their depth chart behind Trevor Lawrence. The move was announced Saturday: QB Nick Mullens will be on the gameday roster. It’s the first of […] The post Jaguars Add New QB for Week 1 vs. Browns appeared first on HEAVY.
Borderlands 4 DLC Character and Free-to-Play Weekend Attract Resurgence on Steam
Borderlands 4 is climbing Steam charts as players fall head over heels for its new DLC character – a Vault Hunter named Loveless the Hacker.
Stars snuggle with adorable rescue puppies at the 2026 Toronto International Film Festival
Check out cute pics of Courteney Cox, Josh Hartnett, Sebastian Stan, and more!
CCHD: Dr. Chad Anderson Awarded With Emerging Health Leader Award
The Christian County Health Department’s (CCHD) Public Health Administrator, Dr. Chad Anderson, has been honored with quite the accomplishment, as he was recently nominated, and awarded with the Emerging Public Health Leader Award by the Illinois Public Health Association (IPHA). Hart Media Group recently […]
The politics and possibilities of ‘AI could kill us all’
I found myself fielding a lot of questions from folks who don’t usually talk much about AI this week. They were mostly along the lines of “do you think AI is going to kill us all?” or “how worried should I be about this human extinction stuff?” Motivating this wave of existential anxiety was the highly dramatic resignation of now-former Anthropic employee Jacob Coxon, who quit his job while publicly sharing his concerns about safety practices at the leading AI companies. More specifically, he declared that almost everyone at OpenAI and Anthropic, the leading AI labs, believes that there’s a decent chance the AI systems they’re producing could “kill us all” by the end of the decade, and the companies aren’t “acting responsibly.” Other AI safety researchers, including those still employed at Anthropic and OpenAI, all confirmed that yes, Coxon is correct, they’re all worried that their company’s products might prove fatal for the entire human race as well. Two more AI employees quit and joined the chorus. Now, the warning shot has been covered everywhere from the Wall Street Journal to Fox News to WIRED to the Guardian. I understand why all this sounds scary, but my response to those who have asked, has generally been: No, you don’t need to worry that AI will kill go rogue and kill us all. But that does not mean we shouldn’t worry, period. Far from it. The companies building AI products are now among the wealthiest and most powerful entities in the world. And they very much are building enormous engines of mass surveillance, extraction, and automation. They can and have allowed their AI systems to carry out felony hacks of other companies, provided the government with autonomously generated kill lists, and sold enterprise technology to firms around the world that is explicitly intended to replace jobs. But “AI” has done these things not because they have all-powerful minds of their own but, ultimately, because people have programmed, calibrated, and directed them to. In other words, it’s not AI we need to worry the most about. It’s the people and corporations working to profit from and gain power by deploying it. The technology is sophisticated, sure, and, especially in cybersecurity contexts, potentially disruptive to plenty of existing systems. But if we want to stop this predatory, profiteering, and extractive form of AI—and it’s worth noting that at this point, most people do—we absolutely can. A quick note/plea: I can only do all of this with the support of readers like you, so if you find value in independent, critical tech journalism and analysis, please consider becoming a paid subscriber. I want to keep as much of this un-paywalled as absolutely possible, and I need your support to do so. Many thanks to all who continue to chip in, it’s very much appreciated. Onward. Subscribe First, some context: AI industry folks like Coxon have been discussing the prospect that AI will destroy humanity for years. Even before the beginning of the AI boom, many working in the industry, from the executive staff to the rank and file researchers, have obsessed over ‘x-risk’, or the possibility that AI will become sentient or semi-sentient and move one way or another to exterminate humanity. This is ostensibly why Elon Musk bankrolled OpenAI in the first place, and is the grounds for his lawsuit alleging OpenAI betrayed its charter by abandoning its nonprofit status to become a commercial enterprise. Many AI engineers and startup founders have calculated their own personal p(doom), or the probability that the tech product they are working on will initiate an actual humanity-extinguishing apocalypse. 10-25% p(doom)s are pretty common. (I wrote about a long weekend I spent among these folks at one of their top conferences here, to give you an idea of their ideas and belief systems.) Sam Altman himself drove the narrative of the imminent rise of a super-powerful AI, or artificial general intelligence, to prominence by declaring that the technology he was building posed an existential risk to humanity. This idea is in other words baked into the DNA of modern AI companies and into the products they engineer. It’s also why the industry is routinely accused, by myself and others, of “doom marketing,” ie, using such proclamations and framings to impart the sheer power of the technology behind your product onto investors, partners, consumers, and the state. Some ambient understanding of this tendency may have helped prevent the press from repeating the claim every time one of the x-risk folks made it over the years, including when they quit their jobs at AI companies while doing so. Yet Coxon’s AI x-risk alarm has broken containment, as they say, and has exposed the idea to the mainstream media once again. This has happened, I think, for a number of reasons. First, when AI CEOs were going around saying AI might kill everyone in 2023, their companies were well-capitalized, but not nearly to the extent they are today. They were more easily dismissed as eccentric geeks of the sort that Silicon Valley is supposed to produce. Now, not only do their products have much greater market saturation, but people are more aware of a) the often unethical ways the executives and companies comport themselves b) the other adverse impacts of AI that have already arrived, and c) the physical cost of building these systems, particularly when it comes to data centers. Finally, toss in the constant stream of headlines in 2026 about AI models going rogue or potentially upending the world’s infrastructure. [ ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) [ With the backlash to data centers, Flock and AI glasses, a mass opposition to big tech is underway. Silicon Valley is in denial. ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) Brian Merchant · Aug 27 [ Read full story ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) As a result, general sentiment was already overwhelmingly skeptical of AI and its overlords, so the table was pretty well set for someone to come along and say ‘just a reminder, the companies that are building the product that promises to take your job and leave a data center in your neighborhood also think that it might exterminate the human race’ and get a strong reaction from the media and the public. The question is: Should we understand this stuff as hype, strategically fanned to feed already swelling valuations? Is it doom marketing? Genuine cause for alarm that the infrastructure that undergirds modern life is facing a novel threat vector? Or reason to be sincerely worried that AI companies are amassing too much power, and that their products are genuinely dangerous? The answer, I’m afraid, is “yes.” Let me try to untangle all of this a bit, because arguments over how to navigate this moment are extremely heated right now, as they are essentially arguments over how to approach the politics of AI at a moment where there may be a unique opening for action. Those sympathetic to AI alignment concerns and x risk arguments—which increasingly includes a faction on the left who want to shut down AI over safety concerns—argue that people who dismiss AI as all hype have their heads in the sand. Meanwhile, critics of the x-risk narrative—which I might note includes a cadre of investors and tech folks on the right, too—argue that it is hype and can be used to further inflate valuations or for pursuing regulatory capture. The challenge is that many feel that dismissing AI as just hype or purely marketing also diminishes the urgency of taking on the AI industry as the novel and threat to labor, civil society, and the public sphere it is; others that by accepting the industry’s own terms, we imbue it with undue power and enable it. But let’s be clear: Declarations that AI is so powerful it might end the world are a kind of marketing, and anyone who says otherwise is just as off base as those who say that’s all that it is. If you don’t think that these sub-trillion dollar companies have higher-ups who noticed that when their founders talked about super-powerful dangerous AI they got spikes in media interest and phone calls from investors, or that those founders didn’t notice that themselves, and lean into certain narratives to advantage their products, then I don’t know what to tell you. Not all marketing is a Pepsi ad campaign with a celebrity spokesperson. Yet confronting the AI industry should certainly be considered an urgent project. Do I share the x-riskers’ fear that out-of-control, super-intelligent AI agents might end the world? I do not. I’ve read a good deal of AI extinction literature over the last couple of years and I have not come across a credible, step-by-step documentation of how exactly AI might move from self-recursively improving AI to killing every single human on the planet. Most of what I’ve read seems predicated on a sort of reverse Ian Malcolmian logic: Eventually, it becomes smart enough and AI, uh, finds a way (to exterminate humanity). Are the AI companies also overstating and dramatizing what their products can do? Yes, pretty much all the time. They’re in a knife fight for market share and are trying to win customers and government contracts before their investors come knocking. And yet. They have concentrated enormous amounts of compute, have extensive data collection and surveillance capacities, have inserted themselves into the state in numerous capacities, including military kill chains, and they are being run by egomaniacal billionaires who are rushing to monopolize an entire new market. The way I think about their most recent frightening-seeming exploits is not as a “swarm of rogue AI agents building a new civilization” or whatever, but as corporations with a hitherto-unimaginable amount of compute at their disposal recklessly experimenting with automation programs, completely unafraid of any repercussions because we have been unwilling or unable to impose any on them. So I think we should welcome any newfound imperative to hold them accountable. I also think that ultimately, the AI critics, Pause AI folks, leftists, doomers, effective altruists, and, honestly, most of the public, want a lot of the same things: legitimate checks and limits on AI companies’ power, actual transparency into what the companies are doing, and for more of AI to be under public control. (Ultimately, a lot of what animates the x-risk fears are rooted in just that: a fear of losing control.) How we move towards all this, exactly, is the question of the day, and while there’s much to be argued over in terms of building a viable political platform to challenge the AI industry’s power, I do want to cast a vote against one particular approach. Not to pick on Chris here, as there are a lot of folks out there proposing stuff like this, and the policy ideas actually stem from AI safety groups. But not only would this be challenging to land politically (I can already hear the ‘China will beat us to AGI’ calls) and all but unworkable in practice, this approach is a) far too limiting, b) fails to address the current harms caused by AI and c) would likely only wind up serving Anthropic and OpenAI; it’s what regulatory capture looks like in action. Full model transparency is the floor for what should be on offer here. If these companies believe their products will kill us, the very least we deserve is to know how. It’s in the public interest. I would also argue we might get a lot of the way to stopping any currently envisioned robot apocalypse simply by forcing AI companies to assume liability, and to submit to the full brunt of the law. If Sam Altman were liable to be charged with a felony for approving the hack on Hugging Face1, if Google was forced to pay defamation fines each time it published a false and injurious AI Overviews, these companies might suddenly find cause to restrain their models’ output, and we might hear less about rogue AI. We would need to introduce new frameworks and available tools for tracking automated lawbreaking, to be sure, but I’d wager that little would frighten the AI companies more than actually being held accountable for what their products enable. To that end, Illinois has passed an AI liability law, which the industry fought tooth and nail, and Florida is considering one. The next steps would be towards moving AI under public control; again, it’s only reasonable, since everyone, not just AI insiders, should get a say over how a technology whose developers say might kill us is developed and deployed. Dismantling the whole industrial project as currently structured should be on the table, too, pending democratic input. But that’s for another post. For now, suffice to say that while I won’t be losing any sleep about an AI-enabled extinction event, Mr. Coxon and co. have given us an opportunity to underscore the urgency of the clear and present damage AI companies are doing, the extreme power they wield and the extent to which they hold themselves unaccountable, and the abundance of political capital there is out there for taking them on. Subscribe 1 Purely speculative! I do not know if he did or not.
Union Grove beats Elkhart at home
GILMER, Texas (KETK) — The Union Grove Lions took on the Elkhart Elks at home on Friday night to start their first run of the season. FINAL: Union Grove 30 – Elkhart 6 Union Grove will face Tenaha at Tenaha on Sept. 18 for their last non-district game of the season. Elkhart will face Winona […]
Watch: Benji Weis with a touchdown run for Pewaukee
Pewaukee's Benji Weis runs for an 11-yard touchdown against Wauwatosa East on Friday, Sept. 11, at Hart Park in Wauwatosa.
Monroe hot sauce company ordered to stop sales over botulism risk: Health officials
HARTFORD, Conn. (WTNH) — The Connecticut Department of Consumer Protection (DCP) is urging the public to not consume hot sauces made by a Monroe company, saying they have a potential Botulism risk.…
Panthers DL Tershawn Wharton remains sidelined, restructures contract
The seven-year NFL veteran remains sidelined and agreed to help alleviate Carolina's tight salary cap.
CT regulators approve double-digit health insurance rate hikes for 2027
CT approved 2027 health insurance increases averaging 11.3% for individuals and 15.1% for small groups.
Bristol life sciences manufacturer delays plant closure, final layoffs until year-end
IDEX Health has delayed the final closure of its Bristol facility and layoffs of up to 15 remaining employees until Dec. 31.
The People on the Move 9/11/2026
Courtesy of Soroptimist International of Fresno Members of the newly chartered Soroptimist International of Fresno gather following the club’s formation in July. The organization launched with 18 members and is led by its first president,
DaVinci Academy of Arts and Science Featured on "All Access hosted by Andy Garcia"
/PRNewswire/ -- An upcoming Public Television broadcast highlights how dynamic charter frameworks and data-informed instruction eliminate achievement gaps in...
DaVinci Academy of Arts and Science Featured on "All Access hosted by Andy Garcia"
An upcoming Public Television broadcast highlights how dynamic charter frameworks and data-informed instruction eliminate achievement gaps in primary K-8 education.
Slack can now vibe-code interactive charts and reports inside chats
It’s even available for free users.
Richford man charged with swiping nearly $1,400 in merchandise from Church Street business
Burlington Police say Tanner Hart, 32, tried to run away from officers and resisted arrest.
Wardogs Surpasses 1 Million Copies Sold on Day One, Blows Past 300k Peak Concurrent Players on Steam
Wardogs has already surpassed a million copies sold and is lighting up Steam's concurrent player charts.
Buffalo River Aviation can fly under own authority
Bentonville-based Buffalo River Aviation Services LLC recently received its Federal Aviation Administration Part 135 air carrier certificate, enabling the company to operate on-demand private charter flights under its own authority....
Buffalo River Aviation can fly under own authority
Bentonville-based Buffalo River Aviation Services LLC recently received its Federal Aviation Administration Part 135 air carrier certificate, enabling the company to operate on-demand private charter flights under its own authority....
Jesus Garcia named new math and science principal at South Jamaica charter school
Jesus A. Garcia has been named the new principal of Advanced Math and Science IV at United Charter High Schools (UCHS) in South Jamaica, which is part of one
Optum Health CEO pulls back curtain on turnaround
As UnitedHealth Group continues to chart its turnaround from a challenging 2025, the company's top brass is pulling back the curtain on those efforts at its healthcare services unit, Optum Health.< | As UnitedHealth Group continues to chart a turnaround from a challenging 2025, the company's top brass is pulling back the curtain on those efforts at its healthcare services unit, Optum Health.
Expo links salmon, culture, science for Effie Kokrine Charter students
Effie Kokrine Charter middle school students received a hands-on immersion into the cultural and scientific relevance of salmon during an inaugural expo on Wednesday.
Scripps Oceanography and Ocean Science Trust Chart Path to Flood Resilience in California
A new OST and Scripps Institution of Oceanography report offers eight recommendations to improve catastrophe flood modeling and link mitigation efforts to insurance pricing, positioning California as a national leader in coastal flood resilience.
Broncos' projected depth chart with practice squad players included
Here's our projected depth chart for the Broncos, with practice squad players included.
When the call involves a mental health crisis, Bridgeport sends more than police
The fatal police shootings of two Hartford men during separate mental health emergencies earlier this year put a spotlight on how Connecticut law enforcement agencies respond to people in crisis and the role mental health professionals can play in those encounters.
See the highest-resolution footage of a black hole jet ever taken, thanks to AI and 27 years of observations
Researchers combined 100-plus images of a single black hole into an AI-powered video to chart the activity of a mighty blazar's jet.
J.K. Dobbins listed as RB1 for Broncos
J.K. Dobbins is atop the depth chart ahead of Week 1.
Major investor of Norwalk-based Xerox urges review of financial services business
Xerox shareholder STARTEEPO is urging Norwalk-based Xerox to review a sale of Xerox Financial Services, which it values at up to $1.5 billion.
Saints Sign Former Unclaimed Broncos Player From 4 Free Agents
With the opener right around the corner, New Orleans brought a handful of former vets in for a look on Tuesday, quietly trying to shore up the depth chart behind Chris Olave.It’s no secret that New Orleans is leaning heavily on young receiving corps behind Olave, making a late-week workout session with the free wideout […] The post Saints Sign Former Unclaimed Broncos Player From 4 Free Agents appeared first on HEAVY.
CBIA survey: Rising household costs add pressure to CT’s business economy
A new survey finds half of Connecticut respondents are financially worse off as rising household costs pressure the state economy.
'Toy Story 5' Secures Third Consecutive No.1 on Weekly U.K. Home Entertainment Sales Chart Through Sept. 9
Disney/Lucasfilm’s Toy Story 5 continues its winning streak on the Official Film Chart, securing a third consecutive week at No 1 on the weekly U.K. home entertainment sales chart through Sept. 9. There were no chart changes among the top six from the previous week. Universal’s Obsession remained at No. 2 in its 10th week … Continue reading "‘Toy Story 5’ Secures Third Consecutive No.1 on Weekly U.K. Home Entertainment Sales Chart Through Sept. 9"
Hartford HealthCare’s health equity summit aims to give clinicians practical lessons
HARTFORD, Conn. (WTNH) — Health equity is about listening, learning, and creating change. Today’s health equity summit aims to give clinicians practical lessons they can take back to th…
Hartford HealthCare, Backus Hospital launch state’s first Mobile Integrated Health program
Hartford HealthCare and American Ambulance launched Connecticut’s first state-designated mobile integrated health program.
Titans Unofficial Depth Chart Ahead of Season Opener vs. Jets
Cam Ward secures the starting quarterback role while Cedric Gray overcomes a concussion scare to lead the defense as Tennessee finalizes its lineup for the Week 1 clash.
This Founder Built a $220 Million Fitness Business. His Playbook Comes Down to 4 Decisions
Tony Hartl has grown Undefeated Tribe, his master franchise for Crunch Fitness, to 4,000 employees and systemwide revenues of $220 million. Here's how.
A path toward justice and public safety
Strangulation can be one of the most dangerous forms of assault; despite the lack of visible ailments it is accompanied by. Though strangulation leaves no broken bones, bruises or visible wounds, it is one of the strongest predictors of future homicides for domestic violence victims. Until this year, second-degree assault by strangulation was not classified […]
66-75: Chart
Mariners Pitchers 2023-2024: Lazaro Montes, +0.20Mariners Pitchers The Other Five Years This Decade: Eduard Bazardo -0.31 WPA, Bryce Miller -0.12 WPA, José Ferrer -0.12 Game Thread Comment(s) of the Day
SK hynix Charts Its Business and Technology Direction at the 2026 Future Forum—”Now Is the Golden Time to Leap Forward”
▲ SK hynix Vice President Jaewuk Ju, head of the Smart Manufacturing Technology/AX Advance department, delivering the first keynote presentation
Arizona Cardinals Week 1 depth chart vs. Los Angeles Chargers
A look at the Cardinals' first depth chart of the season as they get ready to play the Chargers.
SK hynix Charts Its Business and Technology Direction at the 2026 Future Forum—”Now Is the Golden Time to Leap Forward”
▲ A panoramic view of the 2026 SK hynix Future Forum venue On September 8, SK hynix held the 2026 SK hynix Future Forum (Future Forum) at the SUPEX Center on its Icheon Campus under the theme, “The Golden Time
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
What Stands Out About Buccaneers' Week One Depth Chart?
The Tampa Bay Buccaneers' official depth chart had some surprises on each side of the ball. See which players have moved into starting roles ahead of Week 1.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
How Is Hilton Worldwide's Stock Performance Compared to Other Leisure and Entertainment Stocks?
Hilton Worldwide has outperformed the Leisure and Entertainment industry over the past year, and analysts are cautiously optimistic about the stock’s prospects.