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TENNESSEE LADY VOLS SOCCER: Time to recover after two losses

Just five regular season matches remain for the Tennessee soccer team in the 2026 season as the Lady Vols head to the Palmetto State to face No. 11 South Carolina on Friday night. Kickoff from Eugene E. Stone III is set for 7 p.m. ET.

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Oct 8 • 12:27 PM EDT • Sports • sports.yahoo.com
Nvidia Commits $1B To US Science As CEO Jensen Huang Backs Trump’s Genesis Mission

Nvidia commitment will be dispersed over five years with the aim of advancing U.S. scientific research and computing capabilities.

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Oct 8 • 11:55 AM EDT • Science • finance.yahoo.com
Nvidia commits $1 billion to US science over five years

“Putting advanced Super Intelligence in the hands of America’s scientists,” says Jensen Huang as Nvidia commits $1 billion.

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Oct 8 • 11:02 AM EDT • Science • thenextweb.com
NVIDIA Announces Five-Year Commitment to U.S. Science Research

NVIDIA on October 8, 2026, announced commitments valued at $1 billion to build out U.S. capacity for super intelligence research and development over the next five years, in fields the company described as critical for U...

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Oct 8 • 10:59 AM EDT • Science • unite.ai
NVIDIA Announces $1 Billion Commitment to Advance U.S. Science, Quantum Computing and Super Intelligence Research

NVIDIA commits $1 billion to enhance U.S. scientific research and leadership in super intelligence and quantum computing over five years.Quiver AI SummaryNVIDIA has announced a $1 billion commitment over the next five years to advance super intelligence research and development in the U.S., focusing on key areas like quantum computing, healthcare, and energy security. This announcement was made during the Science: A New Golden Age event in Washin

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Oct 8 • 10:40 AM EDT • Science • quiverquant.com
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What We’ve Learned From Penn State’s First Five Games

Penn State's 2026 season isn't off to the start many fans had hoped for. New head coach Matt Campbell had his team at 3-0 after a weak non-conference schedule against Marshall, Temple, and Buffalo, but the Nittany Lions are now 0-2 in Big Ten play. The weaknesses of this Penn State team have been exposed …

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Oct 8 • 10:00 AM EDT • Sports • sports.yahoo.com
2026 Heisman Poll Week Five

Welcome to the 2026 Heisman Poll Week Five. Alabama's Keelon Russell has entered the poll after a big win over Mississippi State. The same game also saw poll favorite Kamario Taylor get injured. We are getting deeper into the season, and the stakes keep climbing. To see all the movement from last week, check out …

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Oct 8 • 9:00 AM EDT • Sports • sports.yahoo.com
Health officials report 74 new measles cases in Pennsylvania

Five people have died in the state.

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Oct 8 • 8:00 AM EDT • Health • abcnews.com
5 Main Street Iowa businesses win $75,000 in state grants

Five small businesses from Main Street Iowa districts were awarded a combined $75,000 in state grants Monday after pitching their expansion ideas in the final round of the 2026 Open 4 Business contest. Open 4 Business is a Main Street Iowa program housed within the Iowa Economic Development Authority’s Downtown Resource Center. The live pitch…

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Oct 8 • 8:00 AM EDT • Business • businessrecord.com
Television Q&A: When will 'The Rookie' be back on patrol?

You have questions. I have some answers. Q: Is “The Rookie” coming back? I think it's been on TV for four or five years, and I can’t find anything about

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Oct 8 • 6:00 AM EDT • Entertainment • recorderonline.com
Covid, Brexit and Liz Truss mini-budget led to lasting decline in mental health, study finds

Researchers found five events, including Russia’s invasion of Ukraine, caused serious damage to mental wellbeing across UK

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Oct 8 • 5:00 AM EDT • Health • theguardian.com
How our reporting team exposed an often deadly toll from a mental health crisis in SC jails

Five-part investigative report exposes a growing mental health crisis in South Carolina’s jails, including more than 100 deaths, with with inmates cycling in and out of custody without getting adequate treatment.

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Oct 8 • 5:00 AM EDT • Health • postandcourier.com
The California colleges where popular majors deliver top pay

These are the five most popular majors at California colleges: business administration, psychology, sociology, communications and registered nursing. And where you go to college to pursue those majors can make

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Oct 8 • 4:15 AM EDT • Entertainment • thederrick.com
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5 steps for CEOs to improve mental health in the workplace

As we mark World Mental Day, a CEO toolkit outlines five actions that C-suite leaders can take to improve workplace mental health, for the benefit of all.

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Oct 8 • 4:00 AM EDT • Health • weforum.org
Kilgore Tec expands its distribution, workforce

Kilgore Tec Products Inc. is expanding its distribution territory and plans to grow its Spokane Valley workforce by about 40% as the building-envelope contractor targets 100% sales growth over the next five years.

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Oct 8 • 3:00 AM EDT • Business • spokanejournal.com
Catching up with: Vestis Manufacturing Inc.

Thirteen years ago, Vestis Manufacturing Inc. was a five-person operation producing and installing fabric awnings for homes and businesses within 100 miles of Spokane. Today, Vestis focuses on manufacturing aluminum canopies, louvered sunshades, and bolt-on balconies for commercial clients…

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Oct 8 • 3:00 AM EDT • Business • spokanejournal.com
Arcadia marks five years as local entertainment option in Burley

Arcadia has been a destination for nostalgia in Burley for the past five years.

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Oct 8 • 12:00 AM EDT • Entertainment • kmvt.com
Debra Messing backs GOP NY gov candidate in political shift

‘The Five’ co-hosts discuss ‘Will & Grace’ star Debra Messing’s surprising political shift after a long period of support for Democrats.

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Oct 7 • 10:40 PM EDT • Politics • foxnews.com
US grants Aurora exemption for self-driving trucks safety feature

The U.S. Transportation Department said late ​Wednesday it approved a five-year ‌exemption for Aurora and other self-driving trucking companies from ​rules that require ​drivers to place warning devices ⁠around a stopped truck.

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Oct 7 • 9:39 PM EDT • Business • reuters.com
Who Won August and September: Original Films or Franchises?

(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) I just heard someone say that if you’re reading a pundit or data analyst, and they don’t tell you that they got anything wrong, they’re not a pundit but an “influencer”. I agree with that. You have to tell your audience when you get things wrong, or they won’t (or shouldn’t) trust you as much. Today, we’ve got another edition of “What I Got Right, What I Got Wrong”. In general, I’m patting myself on the back (and patting very hard) about a few things like IP at the box office, LIV golf, horror films, crowdfunding movies, superheroes, and old people going to the theaters. That said, I also made a couple of data mistakes on the streaming bubble popping and HBO’s datecdotes, so I’m not perfect. But first, I need your feedback... Subscribe Follow-Ups: What Should We Call Mid-Budget Movies Which Aren’t Cinematic Enough for Theaters But Are Too Expensive to Make Money on Streaming? After I asked for feedback on what we should call straight-to-streaming films that are too big to pencil out on streaming but not really big enough to resonate in theaters, I got some great suggestions from you all, including... “Moldilocks” from John Aboud “Little Big Indie” from Travis Frick1 “Midflicks” from Jonathan Funke. “Extra-Medium” from Jona Nwuke. (Read the explanation in the footnote.) Between these and Brandon Katz—who suggested “Bermuda Budget Triangle”, “The Platform Gap” and “The Distribution Deadzone”—we’ve got some excellent suggestions. And they’re better than my suggestion, the “Streaming Budget Dead Zone”, so let’s take a poll! The winning entry becomes the new term. Loading... RIGHT: LIV Golf is Fully Bankrupt…Is Anyone Else Next? A few years ago, I was always a bit perplexed at all the articles I’d read praising LIV Golf and their strategy to disrupt the PGA. LIV Golf, a brand new professional golf league, offered PGA stars ten times what they made on the PGA Tour to join their new league. And folks praised this strategy for its initial “success” in that a lot of big names did indeed leave the PGA. Yeah, of course the players came over. LIV Golf paid them so, so, so much more! But LIV Golf hadn’t discovered a way to increase potential revenue. So think about this in basic business terms… They paid much more in costs… …but had no real way to increase revenue. That’s not a strategy! That’s deficit financing. It won’t work unless you bankrupt the competition (and then turn around and pay those same golfers much, much less). It’s not a sustainable strategy and only lasts as long as the company/person/nation backing it decides they’re cool with losing money. For LIV Golf, that meant Middle East oil wealth, in particular Saudi Arabian money. Clearly, the current Iran War has hurt Middle East finances, so they need to trim their more exorbitant spending. And LIV Golf was part of that trimming. This should be a major warning for others. TGL’s parent company, TMRW Sports, just got a $1 billion valuation, despite TGL’s (the indoor golf league) horrible TV viewership of less than half a million viewers per match. Unrivaled, the women’s basketball league, just secured a $650 valuation, despite its horrible TV viewership and a new rival (Project B) entering the scene next year. To relate this to streaming, Hollywood should ask which streamers may have wealthy patrons funding their losses. (Let’s be clear: Google, Amazon and Apple.) Could those patrons lose their appetite? For Amazon, probably not. But Apple has a new boss, so maybe! WRONG: My Analysis of the Streaming Bubble Was Missing a Week I’m going to be congratulating myself a lot today, but I make mistakes too, like this data goof. When I last compiled the data on the decline in TV shows, I was missing one week at the end of June. If you look at the first image, you can see that one week was mislabelled as “July”. Mainly, this image got updated to show a 27% decline, not 29%: This change doesn’t really impact the overall analysis, but it is two percent better. By the way, through the third quarter, the decline increased and it’s now a 30% decrease since 2022. (I’ll write/visualize this in an upcoming article.) But I want you to trust me and my data. Especially these days, when many people are using LLMs that I know are inserting faulty data into their charts, I want to keep earning my audience’s faith. So that’s the accurate data. RIGHT: IP Remains Very, Very Popular In July, I wrote a giant (and I mean giant) article on Backrooms, Obsession, and the box office, going over what we know, what we don’t know about what works in theaters, looking at YouTubers, IP, the horror genre, comic book movies, and a whole lot more. The month of August really tested a lot of my theses and, being honest, mostly supported my arguments. Let’s start with IP. Looking at 8-Aug (the weekend after Spider-Man: Brand New Day came out) to 18-Sep (the weekend that Resident Evil came out, which I think provides a nice bookend to this time period), there were seven films based on pre-existing IP: Resident Evil (2026) ($126 million) Practical Magic 2 ($65 million) _Insidious: Out of the Furthe_r ($65 million) Coyote Vs. Acme ($59 million) Paw Patrol: The Dino Movie ($53 million) Tony ($15 million) Super Troopers 3 ($7 million) Compare those to the notable original films from the past month—I actually could have included more movies, but here are just thirteen, bringing us to an even twenty films—including.... The End of Oak Street ($54 million) Buddy ($26 million) Mutiny ($15 million) By Any Means ($15 million) The Dog Stars ($14 million) Runner ($14 million) One Night Only ($11 million) Hope ($8 million) Spa Weekend ($7 million) The Uprising ($6 million) Teenage Sex and Death at Camp Miasma ($6 million) Onslaught ($3 million) Eli Roth’s Ice Cream Man ($2.8 million) Here’s that in chart form: Five of the top six films in this time period were all based on IP. I made a big chart of films that grossed over $200 million at the box office before Spider-Man: Brand New Day and The Odyssey hit theaters. Let’s update that chart! By the way, if you want to see how I categorized each film—so another bar chart—here it is: I know that many of my fellow critics/pundits/analysts dislike films based on IP and how Hollywood is making so many of them. And I’m sympathetic to this point of view. As I’ve written many, many times before, you need a balance between existing franchises, new IP, and original films. And Hollywood clearly needs to make more films like Resident Evil (a well-made film from a visionary director) and fewer Practical Magic 2’s (which didn’t get critical or customer buzz). But at some point, critics and pundits need to contend with what audiences are telling them: Movie-goers aren’t showing up to original films. Audiences are speaking with their dollars, telling you they want more IP and franchises. You can try to convince studio heads to make fewer IP-based films and franchises, but the data and numbers aren’t there. Instead, critics need to work harder to convince audiences to show up for original films. Aim your ire/concern at the average person, not studio heads.2 Because they’re just making the films that audiences are telling them to make. WRONG: Original Horror Films Didn’t Break Out I’ll be honest, even though I wrote an article casting some skepticism on the horror genre in July, if you asked me to make a prediction, I would have predicted that, in August, a new, original horror film would have blown up. No, seriously, I just assumed that Obsession and Backrooms presaged a change in audience behavior. But none of the buzzy new original horror films from August—Teenage Sex and Death at Camp Miasma, Onslaught (not an action film in spite of the ads), The End of Oak Street, Eli Roth’s Ice Cream Man, or _Buddy—_broke out. To be clear, exactly one of those films (Buddy) had good “ROI”, but again—I try to be specific in my language—none were “popular” in any broad sense of the word. None of them will be “saving” movies theaters like Backrooms or _Obsession_helped save the summer. The new Insidious film and Resident Evil, both based on IP, were far and away the biggest horror films since July. (We’ll see if this changes in October/Halloween season.) RIGHT: Stay Skeptical about Crowdfunding... I’ve long been skeptical about crowd-investing platforms as one of Hollywood’s saviors, mainly because there’s so much hype/buzz. People need to stay more skeptical about more things, explaining both the potential upside but also the downsides. In particular, the media often hypes crowdfunding at the start and never checks in on the actual results after they’ve come in later. And August gave us our first update! _Ice Cream Man—_directed by Eli Roth—grossed $6 million off of a $5.5 million budget. This is a production of The Horror Section, which was one of the first “crowd investing” studios with 2,400 investors, which means that 2,400 investors probably lost money. They certainly aren’t getting as great of returns as if they had just invested their dollars in the stock market. Hopefully Stiletto (Tagline: “Someone’s Going to Make it Rain Blood!”) does better next month. WRONG: Another Data Goof Here’s another data error. When the first episode of House of the Dragon came out, HBO put out that it had 21.5 million viewers in the first three days, and I read that to mean in the US…but no, it was global. So my US-only datecdotes charts shouldn’t have included it. We never got US-only numbers for the first episode, but for the final episode, HBO put out that it had 11 million US viewers. (And that global dropped to 21 million viewers.) Here’s the updated chart (which I’ve since used in the Streaming Ratings Report): Still, this show is absolutely huge. RIGHT: Superhero Films Remain Very, Very Popular After Supergirl flopped, I read a few takes that “comic book movies are going the way of the Western”. Post-Spider-Man: Brand New Day, that take didn’t age well. To be fair, I have a very nuanced take on the superhero genre right now; it’s down right now, for a lot of reasons. But it’s not “dead”. Maybe _Spider-_Man is just a really popular character? I saw that take, and it’s a fair counter-argument. (But pundits arguing that superhero movies were dead should have mentioned this $1.5 billion counter-argument…) But is it just Spider-Man? The next Avengers film already has $50 million in pre-sales (and I was skeptical that that film would do well) and the Avengers: End Game re-release topped the box office two weekends ago (over three original films). And I wouldn’t bet against Batman or Superman. So maybe it’s just Spider-Man, Batman, Superman and the Avengers. Oh, and Deadpool, of course. And Black Panther. And Wolverine. And probably the X-Men. Plus a well-made Wonder Woman or the Hulk film could break out. But that’s it! It’s just those ten characters/teams. Oh, what’s that? Lanterns is also doing well on HBO? (See previous section…) To be fair, I’m actually pretty sympathetic to the argument that more popular characters—like Spider-Man and Batman—anchor more popular films. In fact, I made that exact argument three years ago when I first wrote about the “Marvel-cession”. In many ways, you can blame The Guardians of the Galaxy for fooling Marvel Studios (and the rest of us) into believing that any character could pop. It turns out, the list of iconic characters is probably smaller than most people think. But it’s probably too early to say that superhero films and comic book movies are dead unless “death” means a slight decline over a longtime. RIGHT: Who Killed Theaters? Old People I get frustrated whenever I see headlines or analysis about how young people are “returning” to theaters. As I’ve detailed(for years), young people have always powered the US box office, despite narratives about “kids these days” and their “phones”. Really, what’s changed post-2020/pandemic is that old people aren’t going to the movies nearly as much. This summer, I saw a movie (from an older director) in a theater near a retirement community, and multiple older people at the theater were talking about how this was their first time seeing a movie in years. I dislike personal anecdotes, so YouGov can fill in the data, best summarized by this headline: “Who killed movie theaters? Not the youths”. According to them, 64% of people aged 18-29 have seen a movie in the last year, but only 30% of 65-and-older. 20% of 18-29 have seen a movie in theaters in the last week and 42% in the last month. Here’s the polling data: Most concerning? Many Americans (17%) think theaters are a worse or much worse experience than watching films at home. Slight WRONG: Hadestown Opens Big A live theater capture of the Broadway musical, Hadestown, made $20 million at the US box office, which begs the question: was I wrong to be skeptical about musicals a few years ago? Yes and no. On the one hand, $20 million is a far cry from being “popular”, so yeah, the genre isn’t that popular overall and Hadestown is one of the more popular musicals from recent years (i.e. the “Taylor Swift Data Fallacy” in action). On the other, I doubt filming this cost all that much, and I don’t think that they spent much on marketing, so this is a good source of ancillary revenue. Smaller Updates WRONG: As I mentioned in a Streaming Ratings Report, I underestimated the budget for Enola Holmes 3. It probably cost more like $50 million, if not more. But... I’m not sure that it really matters? At sub-10 million hours, prices have to come down to make this work. WRONG: Netflix is giving Ink a 27-day in theaters! To quote the kids/YouTubers these days, let’s go! Now I might actually have a chance to see Danny Boyle’s latest in theaters. I’d complained about this in a “Coming Soon” section, but I was heartened to read that Netflix is giving multiple films longer theatrical windows this year. RIGHT: Netflix is sending 4-5 films per year to theaters. Netflix is slowly but surely sending more and more films to theaters, as I cautiously predicted earlier this year. For now, it’s just three big films and a number of awards contenders, but still, this is great news. And they’ll be releasing box office grosses! Just this week, Ted Sarandos confirmed that KPop Demon Hunters 2 will come to theaters (and my guess is it performs in the box office top ten at a minimum). WRONG: Angel has 3 million subscribers! How do I know this? Well, they told Deadline, who reported it. I marked this as “wrong”, since they’ve doubled their subscribers in one year but, you know, they don’t really have a hit film to speak of and they’re still losing money. WRONG: Furious was only renewed for one more season. I accidentally wrote “two more seasons” in my latest “Renewals, Cancellations, Un-Orders and Removals Update”. RIGHT: House of David is ending with its third season. In July, Prime Video renewed House of David for a third season, as I just wrote in my latest “Renewals and Cancellations” report. Well, now it’s ending after that third season. Why? As I’ve been writing, its viewership wasn’t great. I got feedback that this show didn’t cost very much, but it cost enough that its limited viewership didn’t save it. WRONG: Adults was a Hulu original! So I missed Adults when it first came out last year; I saw that it aired on FX and just assumed that it was a linear-first program. Turns out, it aired three episodes on FX, but binge-released the rest of its episodes the next day on Hulu. Huh. So I should have covered it last year! But I just wrote about it. 1 “When I was a kid in the 90s, if you wore a t-shirt to school that wasn’t too big and also wasn’t too small, but somehow didn’t quite fit, we’d say you were wearing an “extra-medium” shirt.” 2 As always, a huge exception is Disney, which barely makes anything original anymore.

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Oct 7 • 6:41 PM EDT • Entertainment • entertainment.substack.com
Kyle Larson Is Putting Together Historic NASCAR Chase Run

Current points leader Kyle Larson’s numbers have been ridiculous halfway through NASCAR’s Chase for the Cup. Larson drove the No. 5 Chevy to a second-place finish at Las Vegas last Sunday, extending his points lead and clocking in his fifth straight top-five finish in the Chase. After finishing 31st in the regular-season finale at Daytona, Larson has […] The post Kyle Larson Is Putting Together Historic NASCAR Chase Run appeared first on HEAVY.

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Oct 7 • 6:30 PM EDT • Sports • sports.yahoo.com
Emery Theater earns awards for historic preservation

The Emery Theater earned five awards after its recent renovations, which transformed the landmark into a permanent home for The Children’s Theatre of Cincinnati.

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Oct 7 • 5:26 PM EDT • Entertainment • spectrumnews1.com
Apple Watch Series 12, Ultra 4 Owners Report Skin Irritation

Some Apple Watch Series 12 and Ultra 4 owners have experienced unexpected skin irritation with the new models, according to reports on the MacRumors forums and Reddit. Affected users complain of a burning sensation and redness under the sensor area. The Apple Watch Series 12 and Ultra 4 measure heart rate every five seconds, and some people have wondered if that's the cause of the skin irritation.

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Oct 7 • 3:02 PM EDT • Technology • macrumors.com
University of Delaware leads $21M program exploring AI in health care

A five-year program centered at the University of Delaware will explore how AI could help medical experts improve physical rehabilitation.

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Oct 7 • 2:53 PM EDT • Health • nbcphiladelphia.com
Forecasting the Next Five Years of Business Jet Deliveries – Part 2

Image: Bombardier Global 7500/8000 Factory Part 1 (https://lnkd.in/ebQSmHXb) laid out the raw material behind this forecast: a six-OEM market where 1Q26 backlog growth ranges from 43% at Bombardier to roughly …

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Oct 7 • 2:49 PM EDT • Business • flightplan.forecastinternational.com
Five Brothers Sushi: From college start-up to lasting business

About ten years ago, Jacob and Ammon Chung saw a need in the community — a spot for late-night eats that wasn't pizza or fast food. That's when sushi came into play.

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Oct 7 • 2:38 PM EDT • Business • universe.byu.edu
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Stacy’s Streamers: Five Players to Start in Week 5

Stacy Perez highlights at least one player at each position who is worth streaming in Week 5.

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Oct 7 • 2:28 PM EDT • Sports • sports.yahoo.com
Cincinnati Children's, First Ladies for Health to host Family Health Day

The program will be held at five churches and a school on Sunday, Oct. 11

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Oct 7 • 1:21 PM EDT • Health • spectrumnews1.com
Newsom announces latest films awarded California tax credits

Thirty-five films were awarded credits

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Oct 7 • 11:51 AM EDT • Entertainment • spectrumnews1.com
Tecsys commits $5M to new Prisma behavioral health hospital

The gift will be spread out over the next five years and will help support operations at the new hospital, which is expected to open in March.

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Oct 7 • 11:30 AM EDT • Health • greenvillejournal.com
Nomination committee appointed ahead of 2027 Annual General Meeting of G5 Entertainment AB (publ)

In accordance with the resolution of the Annual General Meeting 2026, a Nomination Committee has been appointed consisting of representatives of the five largest shareholders at the end of August 2026.The Nomination Committee consists of the following members:The members of the Nomination Committee…

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Oct 7 • 11:15 AM EDT • Entertainment • tradingview.com
Martha Stewart Makes Eyebrow-Raising Admission About Her Business Education

Media mogul Martha Stewart reflected on her five-decade-long business career and shared one piece of advice she still follows. Stewart, 85, also admitted that she did not have much formal business edu...

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Oct 7 • 10:38 AM EDT • Business • yahoo.com
Main Street Iowa businesses win $75k in Open 4 Business pitch contest

Five small businesses located in Main Street Iowa districts – including two in Eastern Iowa – have won a combined $75,000 in state grants after successfully pitching their business expansion ideas Monday night, Oct. 5, in the finals of the 2026 Open 4 Business Competition. The annual contest, housed within the Iowa Economic Development Authority’s […]

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Oct 7 • 8:48 AM EDT • Business • quadcitiesbusiness.com
Award-Winning QB Ashton Daniels's Season Needs Re-Evaluation

Davey O'Brien National QB of the Week Ashton Daniels willed the Florida State Seminoles to victory last Saturday against Virginia, setting a school record with five rushing touchdowns in a 38-7 win. With two losses to ranked teams, the blame for the team's misfortune hardly belongs to Daniels alone.

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Oct 7 • 8:00 AM EDT • Sports • sports.yahoo.com
News | Biggest retail property in Chicago's Loop business district finds new owner

Edwards Realty Group buys five-level Block 37 mall from CIM Group for $30 million

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Oct 7 • 8:00 AM EDT • Business • costar.com
Colts Sign Former Super Bowl Receiver to Practice Squad

The Indianapolis Colts have signed wide receiver Quez Watkins to the practice squad. They also worked out five other free agents.

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Oct 7 • 6:48 AM EDT • Sports • sports.yahoo.com
Silicon Couloir's 15th Pitch Day showcases next generation of Wyoming entrepreneurs

At Silicon Couloir’s 15th annual Pitch Day, five Wyoming entrepreneurs took to the stage at the Center for the Arts in front of hundreds of people and made the case

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Oct 7 • 6:30 AM EDT • Business • jhnewsandguide.com
5 Central Florida restaurants shut down after health inspections last week

The Department of Business and Professional Regulation shut down five Central Florida restaurants during the week from Sept. 28-Oct. 4 after conducting health inspections.

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Oct 7 • 6:00 AM EDT • Health • orlandosentinel.com
Cleveland Browns make five roster moves with their practice squad

Cleveland added two and released five on Tuesday

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Oct 7 • 5:55 AM EDT • Sports • sports.yahoo.com
Ranking Lane Johnson’s five most dominant seasons with the Eagles

Ranking Lane Johnson’s five most dominant seasons, including two championship runs and his remarkable 2022 performance

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Oct 7 • 5:25 AM EDT • Sports • sports.yahoo.com
Melco Resorts & Entertainment Limited (NASDAQ:MLCO) Stock Rated "Moderate Buy" by Wall Street Brokerages

Melco Resorts & Entertainment Limited (NASDAQ:MLCO - Get Free Report) has earned an average rating of "Moderate Buy" from the ten research firms that are covering the firm, MarketBeat reports. Two investment analysts have rated the stock with a sell rating, two have issued a hold rating, five have g

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Oct 7 • 4:29 AM EDT • Entertainment • marketbeat.com
WHO releases first global guidelines on child obesity as cases surge

Child and adolescent obesity has quadrupled since 1990, rising from two per cent to around eight per cent of youngsters in the five-to-19 age group, according to the UN’s World Health Organization (WHO).

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Oct 7 • 3:00 AM EDT • Health • news.un.org
Braves’ Ronald Acuna Jr. Under Fire During NLDS vs. Dodgers

The Atlanta Braves entered Tuesday night in a tied best-of-five series in the NLDS against the back-to-back World Series champion Los Angeles Dodgers. And they’ve been able to hang around despite a continued struggle for superstar Ronald Acuna Jr., whose lack of production at the plate continued into Game 3. Acuna Jr. Struggles in Game […] The post Braves’ Ronald Acuna Jr. Under Fire During NLDS vs. Dodgers appeared first on HEAVY.

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Oct 6 • 11:51 PM EDT • Sports • sports.yahoo.com
Plessinger Signs With Triumph For Supercross And Motocross

Photos by Triumph Racing. Aaron Plessinger is heading to Triumph, inking a two-year agreement to campaign the TF 450-X for 5.11 Triumph Factory Racing in AMA Supercross and Pro Motocross. He takes on an important role in Triumph's 450 development program for the 2027 SuperMotocross World Championship. [cuttext][/cuttext] The move ends Plessinger's five-season run with Red Bull KTM Factory Racing. For Triumph, the signing adds a proven race-winner to a program still establishing itself at the spo

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Oct 6 • 9:40 PM EDT • Sports • sports.yahoo.com
Carlos Alcaraz Wins Japan Open, Sets Sights on Shanghai

Carlos Alcaraz won his third title of the year, and his first since returning from a right wrist injury that sidelined him for five months. He defeated #16 Jiri Lehecka 7-6 (4) 6-4. The victory was Alcaraz's 10th ATP title, moving him past Andy Murray's nine. Only the Big 3 now sit ahead of him: …

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Oct 6 • 7:45 PM EDT • Sports • sports.yahoo.com
Carteret County schools receives grant to expand mental health support

District to receive about $467,000 annually as part of five-year Project AWARE grant.

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Oct 6 • 6:58 PM EDT • Health • witn.com
Five Paddock Market businesses ordered to close over unlicensed activity

Several businesses inside Ocala’s Paddock Market have been ordered to close immediately due to unlicensed activity.

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Oct 6 • 4:12 PM EDT • Business • wcjb.com
Assessing How Phoenix Suns Starters Performed in Preseason Opener

From Devin Booker’s mid-range mastery to Dillon Brooks’ efficient breakout, discover how an aggressive starting five fueled an early lead before a narrow loss to Detroit.

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Oct 6 • 4:00 PM EDT • Sports • sports.yahoo.com
Mainers to walk 76 miles to protest Susan Collins

The walk from Biddeford to Augusta will take a group of at least 15 Mainers five days. The destination is Sen. Susan Collins’ office in Augusta, where protesters intend to demand she stop voting to fund ICE.

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Oct 6 • 3:17 PM EDT • Politics • spectrumlocalnews.com
ASU national security expert explains missteps since 9/11 attacks

The war against terror immediately after the 9/11 attacks had clear goals that were quickly accomplished, but has been followed by many missteps in the 25 years since, according to an Arizona State University national security expert.Peter Bergen, a professor of practice at ASU, recently released the book, “All the President’s Wars: Twenty-Five Years of America's War on Terror.”

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Oct 6 • 2:52 PM EDT • Politics • news.asu.edu
Our first five impressions of Googlebooks

Google’s new laptop OS shows lots of promise for Android phone owners, but there’s a long road ahead.

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Oct 6 • 1:31 PM EDT • Technology • theverge.com
Amazon Prime’s 10 ‘free’ games for October include Five Nights at Freddy’s: Into the Pit and Doom 2016

Amazon Prime subscribers can claim the games to keep via its Luna service…

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Oct 6 • 1:23 PM EDT • Technology • videogameschronicle.com
Extreme Heat Is Making Pregnancy More Dangerous For Mothers And Newborns

Nearly three in four maternal healthcare workers say extreme heat-related complications among pregnant women have increased over the past five years,

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Oct 6 • 12:49 PM EDT • Health • healthpolicy-watch.news
The 2026 Bluebird Banter Haiku Contest: Voting

Time to vote. I took all the haiku that had five or more recs. I had to put them into two polls because of an arbitrary limit that we have on Feed polls. 1: TCasserole Perfection and grace Gallant strides and vapour trails When Kirk steals second 2: Tom__M Walk, single, single Double play, strike […]

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Oct 6 • 12:30 PM EDT • Sports • sports.yahoo.com
Oak Park approves five-year public health plan focusing on equity

The new Illinois Project for Local Needs Assessment, or IPLAN, from the public health department aims to help fix health inequities in Oak Park.

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Oct 6 • 12:12 PM EDT • Health • oakpark.com
Colorado’s best future does not include gerrymandering and political cheating (Editorial)

Shame on Texas Republicans who engaged in one of the dirtiest political tricks America has ever seen — redistricting before the decennial census with the goal of giving Republicans a better chance of winning in five congressional…

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Oct 6 • 11:25 AM EDT • Politics • denverpost.com
Rangers Outfield Prospect Kling Has Massive Day in Fall League

Texas Rangers outfield prospect Paxton Kling went 4-for-5 with five RBI, including a walkoff, as the Saguaros took down the Desert Dogs 8-7.

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Oct 6 • 11:00 AM EDT • Sports • sports.yahoo.com
Northern Virginia business leaders grow more pessimistic about the national economy, survey finds

One in five respondents is based in Alexandria. A majority said data centers are good for the region's economy.

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Oct 6 • 9:42 AM EDT • Business • alexandriabrief.com
'Captaincy ends': Harmanpreet Kaur’s top five achievements as India captain

Harmanpreet Kaur has stepped down as India’s all-format captain after a landmark leadership stint. Her tenure featured India’s maiden ODI World Cup title in 2025, a record number of T20I wins as captain, four Asia Cup triumphs, the milestone of captaining 150 T20Is and a historic Test victory at Lord’s. She now returns to playing cricket.

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Oct 6 • 8:35 AM EDT • Sports • sports.yahoo.com
Burglars target 5 businesses on same block in Greater Grand Crossing

Burglars targeted at least five businesses on the same block in Chicago's Greater Grand Crossing neighborhood early Monday morning.

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Oct 6 • 6:52 AM EDT • Business • cbsnews.com
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Carragher: Manchester City should face three-to-five-year punishment

Manchester City should face a multi-year punishment for their financial misdemeanours, according to former Liverpool defender Jamie Carragher. An independent commission found City guilty of breaking Premier League rules in a strongly-worded report released last week, which the club have appealed against.

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Oct 6 • 6:03 AM EDT • Sports • sports.yahoo.com
Cramming for exams? Five science-backed ways to study better

Rereading and highlighting aren't enough for long-term learning. Experts share science-backed strategies to help students study smarter.

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Oct 6 • 6:00 AM EDT • Science • latimes.com
Bruins struggle with early mistakes, fall to Senators

The Senators have won four of the last five against the Bruins.

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Oct 5 • 11:48 PM EDT • Sports • sports.yahoo.com
Big-Bank Strength, Local Business Insight

A government subcontractor had a chance to win its own contract — one that could increase revenue up to fivefold. A standard credit line based only on current revenue would […]

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Oct 5 • 11:42 PM EDT • Business • wbjournal.com
St. Louis Cardinals Biggest 2027 Challenge? Managing Expectations

I have been a St. Louis Cardinals fan for more than five decades and I have lived through many different eras of losing seasons, championships and everything in between. I can’t recall any of them being more unclear about what the expectations should be for an upcoming season than the one that will hopefully begin […]

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Oct 5 • 9:50 PM EDT • Sports • sports.yahoo.com
Pennsylvania passes 1,000 measles cases as PA health secretary says CDC is minimizing five measles associated deaths

Pennsylvania Health Secretary Dr. Debra Bogen visited a Pittsburgh pharmacy to raise awareness about respiratory illnesses, including COVID-19 and the flu, while addressing the state's rising measles cases.

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Oct 5 • 7:22 PM EDT • Health • wtae.com
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UW-led optoelectronic center receives second round of funding from the US National Science Foundation

A University of Washington-led center for optoelectronics — technologies that combine light and electronics — brings researchers from 14 universities across the U.S. together with the mission to develop new materials to transform information technology with light. Founded in 2021, NSF IMOD has received a second round of funding from the NSF to continue its work for the next five years.

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Oct 5 • 7:15 PM EDT • Science • newswise.com
Former ASU swimmer Grant House helped reshape college sports

Five years after becoming the lead plaintiff in House v. NCAA, former Arizona State swimmer Grant House reflects on the lawsuit that helped reshape college athletics, the leadership lessons he learned and his continued fight for athletes’ voices and collective bargaining with the Protect College Sports Act making its way through Congress.

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Oct 5 • 5:23 PM EDT • Sports • cronkitenews.azpbs.org
Legends Radio spotlights JB Berkow’s lifelong art passion

JB Berkow is the founder of Benzaiten Center for Creative Arts in Lake Worth Beach. LEGENDS RADIO / COURTESY PHOTO This week's Legends Radio Local Artist Spotlight shines on accomplished artist and passionate advocate for the arts, JB Berkow. For more than five decades, JB Berkow has dedicated her life not only to creating art but also to making sure art has a place to thrive. Her work has been exhibited throughout the country in galleries, museums, and universities, and is held in permanent collections, including the Vatican’s Contemporary Art Collection in Italy, Boston University, and Palm Beach International Airport. Her passion for supporting other artists began early. At age 26, Berkow founded Touchstone Gallery in Washington, D.C., which became a highly successful cooperative gallery. She later brought that same entrepreneurial spirit to South Florida, founding Frenchman’s Art Gallery and Studios in Juno Beach in 1995. She opened Rosetta Stone Fine Art Gallery in 2003. In 2015, JB took her commitment to arts education even further by founding the nonprofit Benzaiten Center for Creative Arts. The 15,000-square-foot facility in Lake Worth Beach is home to Florida’s largest publicly accessible glassblowing hot shop and offers instruction in glassblowing, fusing, flameworking, and glass casting. The center also provides free classes to approximately 1,000 underserved children and young adults with disabilities each year. Its “Fragments Reimagined” art therapy program for veterans with PTSD recently received a $100,000 Impact 100 grant. In addition to her work as an artist and advocate, Berkow has authored four books, including Shades of Love and What They Didn’t Teach You in Art School. For JB, art has always been about more than creating something beautiful. It’s about opening doors, inspiring others, and making creativity an important part of life.That is why JB Berkow is in this week’s Legends Radio Local Artist Spotlight.

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Oct 5 • 5:15 PM EDT • Entertainment • floridaweekly.com
Key Recruiting Target Visiting Duke Basketball on Monday

The Duke Blue Devils are getting a visit from a five-star recruit in the 2028 class on Monday.

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Oct 5 • 5:02 PM EDT • Sports • sports.yahoo.com
Pennsylvania's measles outbreak is the largest in decades in the U.S.

There have been 1,004 cases, including 198 hospitalizations and five deaths, Pennsylvania state officials said.

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Oct 5 • 4:43 PM EDT • Health • spectrumlocalnews.com
Pennsylvania's measles outbreak is the largest in decades in the U.S.

There have been 1,004 cases, including 198 hospitalizations and five deaths, Pennsylvania state officials said.

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Oct 5 • 4:43 PM EDT • Health • spectrumlocalnews.com
Five fall business updates for Liberty Hill

New businesses are moving into Liberty Hill, including Crazy Falafels, Cashmere Bar + Board, Gracie Barra, QuesaLab and Milano Nail Spa.

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Oct 5 • 4:23 PM EDT • Business • communityimpact.com
Edison's Entertainment Complex Female Athlete Of Month: Jess Sever Has Made Important Contributions To Edwardsville Girls Flag Football Team

Edwardsville sophomore Jess Sever has five touchdowns as the undefeated Tigers girls flag football team advances in the IHSA postseason.

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Oct 5 • 3:20 PM EDT • Entertainment • riverbender.com
5 faith-filled, family-friendly movies streaming this fall

For viewers looking for faith-filled and family-friendly entertainment as the weather cools down, here are five films making their way to streaming platforms, with stories of faith and courage

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Oct 5 • 3:13 PM EDT • Entertainment • christianpost.com
Waunakee School District nominates five businesses for WASB Business Honor Roll

The Waunakee School has nominated a handful of businesses for the 2026 Wisconsin Association of School Boards Business Honor Roll.

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Oct 5 • 2:49 PM EDT • Business • hngnews.com
Five Plays: NC State First Quarter

Louisville lost another football game on Saturday. They also lost another game that they should have won. Penalties had been a major issue for this team, but they replaced that issue with turnovers this time around. But the biggest issue remains, and that issue is blown coverages by the secondary. For the second straight week, […]

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Oct 5 • 1:59 PM EDT • Sports • sports.yahoo.com
Best Entertainment Stocks To Watch Now

Warner Bros. Discovery, Autodesk, DraftKings, Verizon Communications, and Spotify Technology are the five Entertainment stocks to watch today, according to MarketBeat's stock screener tool. Entertainment stocks are shares of publicly traded companies involved in producing, distributing, or deliveri

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Oct 5 • 1:02 PM EDT • Entertainment • marketbeat.com
5 odd wellness trends people have sworn by

Bodog reports on five bizarre wellness trends, including the tapeworm diet and radium wellness, highlighting their high costs and health risks.

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Oct 5 • 12:00 PM EDT • Health • mesabitribune.com
iPhone 13 Pro vs. iPhone 18 Pro Buyer's Guide: Is It Worth Upgrading?

Apple released the iPhone 18 Pro and iPhone 18 Pro Max in September 2026, five years after the iPhone 13 Pro and iPhone 13 Pro Max. The 2021 models introduced ProMotion displays, macro photography, a 3x Telephoto camera, and substantially longer battery life than their predecessors. They remain capable phones and support iOS 27, but owners now have five generations of upgrades to consider.

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Oct 5 • 11:58 AM EDT • Technology • macrumors.com
Jaylen Waddle scores first TD

Denver Broncos WR Jaylen Waddle had five catches for 35 yards and a touchdown in Week 4.

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Oct 5 • 11:10 AM EDT • Sports • sports.yahoo.com
‘A five-alarm fire’ confronts President Trump in red-state October blitz

The midterm elections were just two days away the last time a sitting president visited Grand Island, the fourth-largest city in the middle of one of the nation’s most reliably Republican states.

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Oct 5 • 10:50 AM EDT • Politics • cnn.com
Anti-trans ballot measures are a political test run for the 2028 presidential election

LGBTQ+ movement leaders warn that anti-trans ballot measures in five states could become a testing ground for a broader political strategy in the 2028 presidential election.

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Oct 5 • 10:00 AM EDT • Politics • yahoo.com
Spurs' Harris questionable for regular-season opener after straining left calf

The 6-foot-8 power forward will be reevaluated following the team’s five-game preseason schedule.

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Oct 5 • 9:50 AM EDT • Sports • spectrumlocalnews.com
Giannis Antetokounmpo: 'I got five, six good years'

Giannis Antetokounmpo: 'I got five, six good years'

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Oct 5 • 9:44 AM EDT • Sports • sports.yahoo.com
PEN America: Nearly 12,000 school book bans in a year, a record high

A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | WBBM Newsradio 780 AM & 105.9 FM

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Oct 5 • 8:30 AM EDT • Entertainment • audacy.com
PEN America: Nearly 12,000 school book bans in a year, a record high

A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | Talk 1370

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Oct 5 • 8:30 AM EDT • Entertainment • audacy.com
PEN America: Nearly 12,000 school book bans in a year, a record high

A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | KNSS Radio

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Oct 5 • 8:30 AM EDT • Entertainment • audacy.com
PEN America: Nearly 12,000 school book bans in a year, a record high

A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | Talk Radio 1210 WPHT

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Oct 5 • 8:30 AM EDT • Entertainment • audacy.com
PEN America: Nearly 12,000 school book bans in a year, a record high

A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | 1010 WINS

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Oct 5 • 8:30 AM EDT • Entertainment • audacy.com
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PEN America: Nearly 12,000 school book bans in a year, a record high

A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago.

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Oct 5 • 8:30 AM EDT • Entertainment • news4jax.com
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Duke Recruiting: Crystal Balls For A Five-Star Target

Are things looking good for Asa Montgomery to Duke?

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Oct 5 • 8:22 AM EDT • Sports • sports.yahoo.com
Lexology Index Recognizes Five Hecker Fink Partners in 2026 Business Crime Defence Guide

Hecker Fink Partners Shawn Crowley, Jenna Dabbs, Mike Ferrara, Sean Hecker, and Amy Jeffress have been recognized in the Lexology Index guide for Business Crime Defence. The 2026 guide honors leading lawyers worldwide who “stand out among peers for their exceptional work representing companies, corporate officers, and individuals in criminal litigation arising from their business activities.”

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Oct 5 • 8:00 AM EDT • Business • heckerfink.com
London City gelling, Man City flying

After five frantic weeks, the Women's Super League takes a two-week break, offering the perfect chance to take stock of a thrilling start to the season.

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Oct 5 • 7:59 AM EDT • Sports • sports.yahoo.com
PFF ranks Michigan State's top five offensive players vs. Wisconsin

Check out who PFF ranked as Michigan State's top five offensive players against Wisconsin.

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Oct 5 • 7:25 AM EDT • Sports • sports.yahoo.com
Carlisle boss Elliot proud of squad after hard week

After a five-game winless streak, consecutive away wins have eased some of the pressure on Carlisle head coach Rob Elliot.

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Oct 5 • 7:19 AM EDT • Sports • sports.yahoo.com
THIS WEEK: “Sick of It! Fix Health Care Now” Bus Tour Kicks Off With Stops in Maine, New Hampshire, New York, Pennsylvania, New Jersey

Rep. Maggie Goodlander (D-NH-02), PA Lt. Gov. Austin Davis Will Headline “Sick of It! Fix Health Care Now” Events in Five States Watch All Bus Tour Stops Live Here. Washington,...

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Oct 5 • 7:00 AM EDT • Health • protectourcare.org
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth

Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine

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