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The Beauty Of Settled Science
Commenters convinced me I made a subtle mis-step in my framing of Psychology Research Is Mostly Fine. My framing emphasized that social priming studies had failed to replicate, but that many other subfields of psychology hadn’t. This naturally led commenters to point to failed replications in other subfields. Although none of these were as bad as social priming, few or none were entirely problem-free. Instead of emphasizing the difference between social priming and other subfields, I should have emphasized the difference between settled science and novel research. Here are some of my favorite psychology findings: The brain is sculpted by reinforcement learning, and a key driver of this learning is a prediction-error-based algorithm located in the nucleus accumbens and implemented through dopamine. Psychedelic drugs exert their effects through 5-HT2A receptors, pointing to a role for these receptors in some sort of construct like the balance between priors and new evidence. Certain cognitive functions are localized to certain brain areas (for example, impulse control to the frontal lobes; linguistic structure to Broca’s area, linguistic meaning to Wernicke’s area. But injure one of these areas, or render a certain function useless (eg a blind person having no more use for their visual cortex), and these mappings can gradually shift - suggesting that neurons are general-purpose compute whose specialization is a contingent fact about convenience and efficiency rather than a necessity. Most personality traits and general capabilities are about 50% genetic and 50% random, with little role for family environment or childhood history, with a few notable exceptions like partisan preference. Recent research complicates this story, but the further you go from this basic picture, the gnarlier the chains of indirect causation you require. Neurons fire together in “brain waves”, whose exact frequency corresponds with the character of consciousness; These divide neurons into natural subpopulations and linked graphs. The gamma rhythm corresponds surprisingly well to items in conscious awareness. GABA receptors seem to be involved in something like relaxation. By hitting different GABA receptors in different ways, you can modulate the exact type of relaxation you produce. Hitting GABA-A directly is too powerful and can cause dangerous levels of sedation, but allosteric modulation of GABA is an incredibly fruitful strategy that underlies drugs from benzos to barbituates to alcohol. If you know your GABA-A subunits, you can target specific subtypes of relaxation; for example, Ambien hits GABA-A1 and induces sleep. Memory divides somewhat fuzzily into bins of immediate-sensory, short-term, and long-term, with separate retrieval and storage functions, and separate systems for declarative vs. procedural learning. These can be harmed selectively, usually by hippocampal injury, so that some patients can remember their life stories but not form new long-term memories, or learn new skills like bike-riding but not new facts. The exact substrate of memory is unclear but seems to involve new synaptic connections between neurons in at least some way. The ability of modern psychology and psychiatry to treat mental illness is real but limited. SSRIs work for half or slightly fewer than half of patients; antipsychotics work with extreme side effects; benzodiazpines work but produce addiction and tolerance in many (not all) people. Most supplements are stuck in Poor Quality Study Replication Crisis Hell, but melatonin and l-theanine stand out as especially promising. Psychotherapy works with moderate effect size, but (with a few exceptions) seems to be more about the relationship with the provider than the details of the therapy itself. Mental hospitalization can sometimes defuse immediate crises but work less well than mental hospitals would like, with some studies showing overall negative effects. Schizophrenia is mostly genetic, but risk also increases with prenatal infection (especially rubella) and obstetric complications; there is suggestive evidence for roles of social stress and drug use (with psychedelics and marijuana making things worse, and nicotine if anything making things better). Bipolar and schizophrenia are so closely linked on a pathophysiological level that it seems like they might be the same disease; on the clinical level, they do seem to follow two separate courses/prognoses but can sometimes surprise clinicians by eg someone who seemed condemned to permanent schizophrenia unexpectedly recovering. The brain’s native reinforcement learning algorithms cash out in the phenomena of classical and operant conditioning; different reinforcement schedules reinforce at different levels, which can be exploited by bad actors to make especially compelling products (eg slot machines). None of these are immune to doubt. A few are speculative; one or two are genuinely unorthodox. But they’re all a step above one p = 0.049 paper that might not replicate. If they get overturned, they’ll be overturned by the same sort of genuine scientific shift that replaced Ptolemy with Copernicus or Lamarck with Darwin, not some sort of sordid discovery about someone entering random numbers into a spreadsheet. In 2008, Eliezer Yudkowsky wrote about The Beauty Of Settled Science: If you only care about scientific issues that are controversial, you will end up with a head stuffed full of garbage. The media thinks that only the cutting edge of science is worth reporting on. How often do you see headlines like “General Relativity still governing planetary orbits” or “Phlogiston theory remains false”? So, by the time anything is solid science, it is no longer a breaking headline. “Newsworthy” science is often based on the thinnest of evidence and wrong half the time—if it were not on the uttermost fringes of the scientific frontier, it would not be breaking news. Scientific controversies are problems so difficult that even people who’ve spent years mastering the field can still fool themselves. That’s what makes for the heated arguments that attract all the media attention. Worse, if you aren’t in the field and part of the game, controversies aren’t even fun. Don’t be embarrassed to read elementary science textbooks, either. If you want to pretend to be sophisticated, go find a play to sneer at. If you just want to have fun, remember that simplicity is at the core of scientific beauty [...] A steady diet of science news is bad for you: You are what you eat, and if you eat only science reporting on fluid situations, without a solid textbook now and then, your brain will turn to liquid. Psychology isn’t centrally the new paper in Annals Of Recently-Breaking News saying that an n=5 study showing that large portion sizes increase support for terrorism. Psychology is centrally ideas like brain waves, GABA receptors, reinforcement learning, twin studies, and connectionism. People who think differently are worrying too much about BREAKING NEWS!!!, and should stop. The key distinction isn’t “recent research in social psychology” vs. “recent research in cognitive/bio/behavioral psychology”, as my essay last week unfortunately implied. It’s recent research in general vs. the deposit of settled science, battle-tested hypotheses, and carefully-earmarked speculation. And part of the reason social priming in particular was such a disaster was that it defied that heuristic, building itself up over hundreds of studies until it approached or even entered the pantheon of settled science - before collapsing (5-HTTLPR was also sort of like this). This isn’t a claim that settled science is always right - Freud was “settled science” for a long time - just that there’s an intuitive distinction between the level of credence you should have in the existence of power posing vs. the existence of Broca’s Area. (I compounded this error by calling the last post “Psychology Research Is Mostly Fine”, which suggested I was talking about the new research rather than the settled science. I actually meant to distinguish between research-psychology-the-field vs. clinical-psychology-aka-therapy, but this framing unintentionally pushed against the point I wanted to make) Some commenters on the previous article understood this point, but challenged its weight. It’s very cool, they said, to know how many neurons are in which brain lobe, but the main way that Psychology affected their lives was through bad clickbait studies used to buttress dumb policies; some p = 0.049 study says that exposure to microaggressions makes minorities’ brains shrivel into raisins, and now their company has to implement punitive DEI or be sued for hazardous work conditions. I won’t dispute this as an accurate description of how the sausage gets made, but it’s worth examining the trains of thought that connect this observation to a campaign against psychology in general: The dumb woke psychology was wrong and bad, and I don’t have good heuristics for distinguishing dumb woke psychology from other psychology, so I’m going to assume it’s all wrong and bad. The dumb woke psychology was wrong and bad; it seems useful to punish/discredit psychology as a whole to assist my campaign against it, so for propaganda purposes I will try to discredit psychology as a whole. To people in the first camp, my response is: come on, your heuristics aren’t that bad. “Microaggressions makes minorities’ brains shrivel up like raisins” is in the woke category; “the hippocampal theta rhythm seems to be associated with both memory and pathfinding, suggesting an unexpected yet surprisingly compelling relationship between the two” is in the not-woke category, don’t play dumb here. To people in the second camp, my response is: deliberately exaggerated propaganda campaigns are bad and this is a confession, not an excuse. Inability to view science through anything but a political lens was what got us into this problem; doubling down on it is a temporary solution but a recipe for permanent disaster. If you pronounce entire fields of science to be acceptable collateral damage in your campaign against bad political actors, you will alienate not just scientists but patients, clinicians, and general lovers of truth. Instead, you can say the thing you mean - that woke partisans shouldn’t try to occupy and exploit the otherwise-noble science of psychology for their own political gain - and wage the same campaign with a halo rather than a comic-book-villain goatee. From the font of oracular wisdom that is Weird Sun Twitter: [ Vessel Of Spirit@VesselOfSpirit i love you all conditionally but i love the good part of you unconditionally. even if it becomes a very small part 2:11 AM · Jan 22, 2015 1 Reply · 5 Reposts · 29 Likes ](https://x.com/VesselOfSpirit/status/558084551772471298) This is how I feel about psychology1, too, but with a touch more optimism. The good part of psychology is enormous, a hoard of endless treasures. You just have to look past the headlines! 1 To play devil’s advocate - should one always be so magnamious? Astrology? Phrenology? These seem different in that their entire orientation was flawed from the start; they didn’t simply fail to find the correct constellation-personality connections, the whole project of searching for connections between constellations and personality was doomed from the start. More difficult might be asking the same question about education research, which is notoriously bad. I don’t know enough about education research to know if there’s some settled science of correct and enlightening results lurking in the background beyond the day-to-day froth of poorly-conducted and politically-motivated studies. I think if it’s 90% bad, 10% good, it’s correct to call it bad as a compact way of communicating a useful truth; I think psychology is better than that, but admit it’s a tough judgment call.
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Handover of Health Commodities
Joint Handover of Health Commodities Speech of Chargé d’Affaires Steve Bremner (…) Thank you for joining us. I am here today to demonstrate how U.S. foreign assistance under President Trump’s America First Global Health Strategy and our bilateral health MOU makes America safer and stronger while helping Madagascar build a more self-reliant health system. Through our bilateral Global Health Memorandum of Understanding (MOU) signed in December 2025 with the Ministry of Public Health, our two governments outlined shared priorities and responsibilities, including a strong focus on infectious disease threats and Madagascar’s increasing ownership and co-investment in its own health system. The MOU outlines the structure and terms of U.S. support to Madagascar’s health sector from 2026 through 2030, with a total commitment of $134,305,000 from the U.S. government and $41,216,252 from the Government of Madagascar to work jointly to address malaria, maternal and child health, polio and global health security issues. Stronger health systems help prevent instability and reduce the risk that infectious diseases reach the United States, making both our countries safer. America First foreign assistance is clear and disciplined: It is a tool of strategic engagement, not global charity. Every U.S. taxpayer dollar must show measurable results, reduce long-term dependence on U.S. taxpayer resources, and support greater self-reliance in recipient countries. Support must be efficient and targeted, with zero tolerance for fraud, waste, or abuse. This year, through the U.S.-funded Global Health Supply Chain Program – Procurement and Supply Management project, we are distributing: 989,250 long-lasting insecticide-treated nets, worth $2,000,000 to 63 districts and 1,661 Community Health Centers across Madagascar, with the third and final delivery of these nets having arrived in late June. Through the U.S.-funded Momentum Country and Global Leadership (MCGL) project, we are funding: The full cost of Starlink internet connectivity equipment procurement, installation, and one-year subscription for 31 priority District and Regional Health Offices. Through the U.S.-funded Strengthening Infectious Disease Detection Systems project, we are supplying: 908,523 pieces of critical medical equipment and a modernized digital surveillance system to the Ministry of Public Health. These materials will strengthen health systems, improve response capabilities, and help those most in need of protection from mosquito-borne diseases — particularly malaria, which continues to claim the lives of children and women at an unacceptable rate. Deployed effectively, they will contribute to reducing maternal and newborn mortality in rural and hard-to-reach communities where the need is greatest. In these same underserved areas, Starlink connectivity will play a critical role in enabling the rapid transmission of health data and information to central levels, ensuring that decision-makers receive timely, actionable intelligence and can mount swift, coordinated responses to protect populations. For Americans, this support delivers concrete benefits. Stronger health systems in Madagascar help detect and contain infectious diseases before they spread across borders, protecting American and Malagasy families. More stable, healthier countries can expand trade and economic cooperation with the United States. Our goal is not permanent support; it is temporary, targeted assistance that helps Madagascar save lives while achieving greater self-reliance and independence from foreign assistance. To the health workers and community health agents here that will use the products we’re delivering today: your dedication and skills save lives. Your work exemplifies the kind of local ownership that will enable Madagascar to reduce dependence on foreign assistance and manage the country’s health challenges. This targeted support delivers results today while helping Madagascar build toward a future where it can sustain and expand those health gains independently, ensuring that today’s U.S. support leads to Madagascar’s self-sufficiency. Thank you, Misaotra.
United States Delivers Life-Saving Health Supplies and equipment to Madagascar
United States Delivers Life-Saving Health Supplies and equipment to Madagascar U.S. Chargé d’Affaires Steve Bremner presided over a handover ceremony to the Government of Madagascar, represented by President of the Refoundation Col. Michaël Randrianirina, marking the delivery of nearly one million mosquito nets, over 900,000 pieces of critical laboratory equipment, and 33 internet connectivity systems. The assistance – valued at more than $2.2 million – is part of a broader U.S.-Madagascar health partnership, outlined in our bilateral Global Health Memorandum of Understanding (MOU) signed in December 2025, totaling $134 million from the U.S. government from 2026 through 2030. “This assistance is clear and disciplined – it is a tool of strategic engagement, not global charity,” said Chargé d’Affaires Steve Bremner. “Every U.S. taxpayer dollar must show measurable results, reduce long-term dependence on U.S. resources, and support greater self-reliance. Stronger health systems in Madagascar help detect and contain infectious diseases before they spread across borders, protecting American and Malagasy families alike.” The assistance includes: 989,250 long-lasting insecticide-treated mosquito nets - worth $2 million – will be distributed to 63 districts and 1,661 community health centers across Madagascar. Malaria remains one of the leading causes of death in the country, claiming the lives of children and women at an unacceptable rate. The third and final delivery of these nets arrived in late June and will be distributed starting this July until mid-October, ensuring that those most at risk of mosquito-borne disease now have access to this basic but life-saving protection. U.S.-funded Global Health Supply Chain Program – Procurement and Supply Management (GHSC-PSM) project will ensure the distribution. 908,523 pieces of critical medical and laboratory equipment – valued at $180,000 – including personal protective equipment, laboratory supplies, diagnostic tools, and cold chain equipment – along with a modernized digital surveillance system to Madagascar’s Ministry of Public Health. This support through the STRIDES (Strengthening Infectious Disease Detection Systems) program bolsters Madagascar’s ability to detect and respond to outbreaks of diseases such as monkeypox, plague, rabies, polio, and Ebola before they become regional or global threats. Over $30,000 of funding for the full procurement, installation, and first year of service for 33 Starlink satellite internet systems at priority districts and regional health offices across the country. These systems will allow health workers in remote and underserved communities to transmit health data quickly to central decision-makers – enabling faster, better-coordinated responses when disease outbreaks occur. U.S.-funded Momentum Country and Global Leadership (MCGL) will implement this project. As the country’s largest bilateral health donor, the United States remains committed to the principle that a stronger, healthier Madagascar makes for a stronger, safer world – and a stronger, safer America.
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AeroSafe Global turns sustainable healthcare logistics into a high-growth business
Rochester-based AeroSafe Global pioneers cold-chain-as-a-service, employing nearly 200 locally and operating in 80 countries with sustainable pharma logistics.
New research traces how ‘forever chemicals’ move through the Great Lakes and into people
The study used more than 40 years of data to map fluctuating PFAS levels across species in the region's food chain.
Fast-food chains face growing competition from grocery stores
Fast-food chains face new competition as grocery stores expand prepared-food options, challenging traditional drive-thru value meals.
International Business Machines (IBM) Joins Hands With Deloitte and Red Hat Against Automated Cyberattacks
International Business Machines Corp. (NYSE:IBM) is one of BlackRock’s 30 most important AI stocks right now. On June 26, International Business Machines Corp. (NYSE:IBM), together with Deloitte and Red Hat, formed a partnership to help provide businesses with greater protection against rapidly evolving, automated cyberattacks targeting the software supply chain. To increase the security of […]
FEATURE: Who will inherit Japan? Aging owners fuel new era of business succession
Like thousands of other Japanese business owners, Kisshokichi founder Kiyomi Akagi, who built one of the world's largest certified Kobe beef chains, faced the challenge of succession. To ensure his company's future, he sold a majority stake in the business.
Report: iPhone Ultra to have incredibly limited availability at launch, may ship slightly later
According to supply chain analyst Ming-Chi Kuo, Apple is likely to have very limited supply for iPhone Ultra at its...
‘All kinds of weird’: novelty store to open in midtown Sacramento
Ginger & Raven will operate on 1731 L St. selling novelty and accessory items such as keychains, compacts and Italian charm bracelets.
iPhone 18 With 9GB RAM Still Won't Support Two New iOS 27 Features
The lower-end iPhone 18 and iPhone 18e will be equipped with 9GB of RAM, up from 8GB in the iPhone 17 and iPhone 17e, according to supply chain analyst Ming-Chi Kuo. In a social media post, Kuo said the 1GB increase in RAM will ensure that Apple Intelligence features continue to run smoothly on the pair of devices. The higher-end iPhone 18 Pro, iPhone 18 Pro Max, and foldable "iPhone Ultra" will each have the same 12GB of RAM as the iPhone 17 Pro models, added Kuo.
Lil Wayne a no-show for concert that was supposed to kick off his tour
Rapper Lil Wayne was scheduled to perform Tuesday in Bangor, Maine. But the show ended after opening act 2 Chainz and a DJ performed.
Securitize Completes Business Combination with Cantor Equity Partners II
/PRNewswire/ -- Securitize Corp. ("Securitize"), the world's leading tokenization platform with over $4 billion in assets brought onchain, today announced the...
DOOM: The Dark Ages Goes Supersonic With New DLC Chain Spear
DOOM: The Dark Ages | Revelations is its first major DLC, showcasing a versatile new Chain Spear. Read more inside to learn about the deep movement tech it adds to the game:
America 250 Is Rewriting the Business Case for Made in America
Naturepedic’s Arin Schultz examines why America’s 250th anniversary coincides with a fundamental shift in manufacturing strategy. Schultz argues that tariff uncertainty, supply-chain disruption and…
FDA staff recommendation undercuts RFK Jr.’s push to expand peptides
The chains of amino acids are increasingly marketed for antiaging and health benefits. However, medical experts say many of those claims have not yet been fully tested.
Beloved gas station pizza chain CEO reveals 400-store expansion plan as food business booms
Casey's General Stores plans to add at least 400 new locations over three years while expanding its prepared food menu with wings and fries.
These Michigan businesses are finding a silver lining with tariffs
Resale and salvage retailers are taking advantage of a circular, domestic supply chain as shoppers shift to bargain-hunting and buying local.
Science Helps Verify Cotton's Origin - AG INFORMATION NETWORK OF THE W
The U.S. Cotton Trust Protocol is adding forensic testing to strengthen confidence in cotton supply chains.
What’s Open, What’s Closed: Big changes for a few businesses, while chains add Denton County locations
Harvest House and Flowergarden118 find new ownership. The Chestnut Tree Tearoom & Bistro and Fiesta Eats Hub close. Target, Bath & Body Works and Panda Express open new locations in
Tariffs continue to add uncertainty to business climate: Top Workplaces 2026
Companies like Gardiner HVAC in Solon are navigating fluctuating prices and supply chain disruptions as tariff policy remains volatile more than a year after implementation.
Scientists finally explain why these wild boars stay more radioactive than Chernobyl's wolves - Futura-Sciences
What explains this surprising finding? The answer appears to be a complex mix of history, ecology, and diet. Bavaria’s wild boars mainly feed on underground fungi that absorbed radioactive fallout from both the notorious Chernobyl disaster and Cold War-era nuclear testing. Unlike wolves, which sit higher on the food chain...
Testing gives science-based data for Fairmont lakes
FAIRMONT— A partnership between the city of Fairmont and Minnesota State University-Mankato will result in comprehensive scientific data on the Fairmont Chain of Lakes. The $25,000 contract started on April 1 and will go through Dec. 31 of this year. Fairmont’s Water Resources Coordinator, Hannah Neusch, acknowledged that while the water treatment plant in Fairmont […]
Public health alert issued for chicken sold at popular grocery store in the Tri-State area
A public health alert was issued for chicken sold at a popular grocery store chain in the Tri-State area.
Colonial Market owner closes south Minneapolis location due to sharp drop in business following Metro Surge
Colonial Market owner Daniel Hernandez has closed the chain’s south Minneapolis location, which he said never recovered after the store’s employees and customers were targeted during Operation Metro Surge.
Merck KGaA to Acquire Bio-Techne for $11.3B, Expanding Life Science Tools Presence
Merck KGaA, Darmstadt, Germany, has agreed to acquire Bio-Techne for approximately $11.3 billion, the companies said today, in a deal designed to position the buyer as more of a leader across the life science value chain by expanding its presence in high-growth, next-generation life-sci markets with Bio-Techne’s tools, analytical technologies, and consumables.
Consumer Discretionary Stocks Drawing Institutional Rotation Into Live Entertainment Leaders
With the Federal Reserve hinting at a pause in rate hikes, stubborn inflation still in the background, and several large companies surprising on earnings, consumer discretionary stocks are back in focus for investors weighing risk and opportunity. This article looks at how that mix of easier policy signals, solid corporate reports, and ongoing geopolitical and supply chain issues could affect larger U.S. consumer-focused companies. It will walk through 3 stocks from a curated screener that...
Chick-fil-A gets into the home repair and services business
The popular chicken chain has brought its hospitality prowess to a new industry in metro Atlanta — home services.
New supply chain report claims the iPhone Ultra will be unveiled as scheduled
When it will actually be released is another matter. Last week, a report from Apple's supply chain indicated that the iPhone Ultra would be delayed. This...
Gwyneth Paltrow’s health-food restaurant coming to a second San Diego location this fall
The Goop Kitchen restaurant chain is part of Paltrow’s Goop business, which also sells beauty, wellness, clothing and lifestyle products.
I ordered the same meal at Olive Garden and Carrabba's; clear winner
I compared bread, salads, entrées, and desserts from Olive Garden and Carrabba's to see which Italian-American chain had the better dishes and deals.