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From Shells to Science

If you were a fifth grade student at Manatee Elementary School, coming to school on a Thursday after Spring Break might not seem very exciting at first.

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Mar 26 • 12:00 AM EDT • Science • coastalbreezenews.com
Tulsa students advance to state science fair with research on health and technology

Three Tulsa students are heading to the Oklahoma State Science and Engineering Fair after earning top honors at regionals, presenting research on medication safety and hearing loss among young people.

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Mar 25 • 6:33 PM EDT • Science • newson6.com
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Artemis Moon Tree Dedicated in Honor of Mary W. Jackson

On March 18, 2026, students, staff, and members of NASA’s Langley Research Center gathered at Mary W. Jackson Elementary School in Hampton to celebrate the

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Mar 25 • 5:19 PM EDT • Science • science.nasa.gov
Hastings College professor, students present research at political science conference

A Hastings College professor and four students recently traveled to the University of Missouri–Kansas City to present original research at the Great Plains

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Mar 25 • 3:57 PM EDT • Politics • hastings.edu
Hastings College professor, students present research at political science conference

A Hastings College professor and four students recently traveled to the University of Missouri–Kansas City to present original research at the Great Plains

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Mar 25 • 3:57 PM EDT • Science • hastings.edu
Grad students earn awards for national energy research

For MSU graduate students Ethan Fletcher, Bill Good and Brandon Kristy, the program supports their thesis research in collaboration with host scientists at U.S. National Laboratories.

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Mar 25 • 3:56 PM EDT • Science • msutoday.msu.edu
Student-led business hooks customers across the country

Stay up to date with the latest news, stories, and achievements from the Susquehanna University community.

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Mar 25 • 3:49 PM EDT • Business • susqu.edu
Students ‘Surge’ with fun at local entertainment center

Have you ever wanted to visit an arcade, a restaurant and a bowling alley all in one place? Surge Entertainment by Drew Brees combines all three in same building, along with more activities including laser tag and sports simulators. While the venue offers variety, its attempt to do everything at once leaves certain areas underdeveloped,...

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Mar 25 • 3:01 PM EDT • Entertainment • ulmhawkeyeonline.com
High school students pitch business ideas during competition at Lincoln Financial Field

The group of students was selected from over 30 submissions.

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Mar 25 • 12:26 PM EDT • Business • 6abc.com
Winter sports teams earn scholastic honors - Fayetteville-Manlius CSD

All 10 of the Fayetteville-Manlius School District Winter 2025-26 varsity sports earned Scholar-Athlete status from the New York State Public High School Athletic Association (NYSPHSAA) Section III. This accomplishment is earned by 75% or more of the varsity roster having an average grade point average (GPA) of 90% or above; 171 student-athletes earned that accomplishment.

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Mar 25 • 12:02 PM EDT • Sports • fmschools.org
Business Titan Awarded Student Employee Scholarship

Business administration student Trisha Tran Truong was selected as the fall 2025 recipient of the Auxiliary Services Student Employee Scholarship, which recognizes a student employee who demonstrates academic dedication, leadership and a strong commitment to serving the campus community. Truong has been a member of the campus dining team since 2022, working at the on-campus […]

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Mar 25 • 12:00 PM EDT • Business • news.fullerton.edu
KCCI Investigates: What one science teacher taught students about water quality

First- through fifth-grade students at Bergman Academy in Des Moines took on one of Iowa's biggest environmental issues at the school's first science fair: water quality.

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Mar 25 • 11:55 AM EDT • Science • kcci.com
Criminology, political science student turns resilience into leadership

Through mentorship, leadership in the Liberal Arts Chaiken Center, and service to her Pittsburgh community, Trinidy Manison, a Penn State College of the Liberal Arts student, has committed to uplifting others while preparing for a future in law.

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Mar 25 • 11:40 AM EDT • Science • psu.edu
Professor motivates students to nurture their inner entrepreneur

Mercer University professor Dr. Briana Stenard approaches teaching with a spirit that demonstrates that the best learning prioritizes confidence and ingenuity.

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Mar 25 • 8:30 AM EDT • Business • den.mercer.edu
Examining government-business relationships in Chile - College of Arts and Sciences

Graduate student Jaime Lindh studies the relationships between local governments and business communities in his native country of Chile.

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Mar 25 • 8:29 AM EDT • Business • college.unc.edu
From idea to publication: How RISE Ambassadors are impacting science education

When Sara Brownell began the RISE Ambassadors program three years ago as part of her Charter Professorship, she hoped to make a positive impact on STEM learning environments by empowering undergraduate students to have greater agency in both the research conducted and its translation into meaningful change.

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Mar 25 • 8:00 AM EDT • Science • news.asu.edu
STUDENT ORG SPOTLIGHT

Colorado Law is home to nearly 50 active student organizations. These organizations empower law students to increase their knowledge, gain leadership

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Mar 25 • 8:00 AM EDT • Health • colorado.edu
RPI Athletics Celebrates 50 Years of Women's Sports

Rensselaer Polytechnic Institute proudly celebrates 50 years of women's varsity athletics—a milestone that reflects decades of progress, achievement, and opportunity for generations of student-athletes. What began as a commitment to expanding access in intercollegiate athletics has grown into a vibrant and competitive tradition that continues to shape the RPI community today.

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Mar 25 • 8:00 AM EDT • Sports • rpiathletics.com
Two-Time National Champion Boxer, Business Student Aidan Jubb: ‘When the Final Bell Rings…You’re Like, ‘Is It Already Over?’’’

'Winning is great, and that's when the hard work pays off'

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Mar 25 • 7:30 AM EDT • Business • today.uconn.edu
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How this Indiana teacher makes her AP personal finance class click for students

With over two decades of teaching under her belt, Kristin Lidstrom is piloting the AP class for Fishers students. “By the time students are making real financial decisions, they should already feel confident navigating them, not encountering the concepts for the first time,” she said.

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Mar 25 • 7:00 AM EDT • Business • chalkbeat.org
Charles County Science Fair Winners Announced Following Annual Expo

WALDORF, Md. – Charles County Public Schools (CCPS) held the 10th annual History, Industry, Technology and Science Expo, also known as HITS, on March 21 at St. Charles High School. Each year the Expo features student history and science fair projects on display for judging. Science fair project categories included behavioral/medicine and health science, chemistry, […]

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Mar 25 • 6:00 AM EDT • Science • thebaynet.com
Should computer science be compulsory in Ohio schools?

Currently, twelve states in the US are phasing in requirements for students to complete a computer science course before graduating high school. Should Ohio become the 13th state? That is what a pair of bills in the Ohio Statehouse are proposing to do.

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Mar 25 • 3:30 AM EDT • Science • ohiocapitaljournal.com
New business program to train students for competitive industries

Rice’s Virani Undergraduate School of Business announced the Moody Business Scholars Program on March 12. The program will introduce a new initiative to prepare students for careers in competitive industries.

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Mar 25 • 1:28 AM EDT • Business • ricethresher.org
IPS Students Showcase Data Science Skills with Pascal Siakam at Arsenal Tech

Pascal Siakam of the Indiana Pacers will visit Indianapolis Public Schools (IPS) on Thursdaay, March 26 to celebrate student achievements in the ‘Data Dunkers’ program. Driven by a partnership between the PS43 Foundation and Dell Technologies, this initiative leverages basketball to teach foundational STEM and data analysis skills. During the event, Siakam will meet with… Read More »IPS Students Showcase Data Science Skills with Pascal Siakam at Arsenal Tech

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Mar 25 • 1:03 AM EDT • Science • myips.org
The Student Entertainment Board to host their third drag show on March 27

SEB hosts various events throughout the school year, from all night parties and haunted houses to daily movie nights and more. As spring approaches and the clocks move forward, SEB shifts its focus to one of campuses most anticipated and vibrant events of the season: an Up All Night Drag Show. This year, the drag...

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Mar 24 • 10:07 PM EDT • Entertainment • dailyevergreen.com
Cordova students will compete in Alaska Science Olympiad

Students will be traveling from Cordova, Keni, Minto, Nome, Palmer, Seldovia and Utqiagvik to compete with counterparts in the Fairbanks North Star Borough.

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Mar 24 • 9:03 PM EDT • Science • thecordovatimes.com
Ten Pieces of Non-Technical Career Advice for Engineering and Computer Science Students

At a new event focused on student success and career readiness at the Jacobs School of Engineering, alumni and faculty shared non-technical career advice with current students.

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Mar 24 • 8:00 PM EDT • Science • today.ucsd.edu
Midland ISD CTE Animal Science Program: Career Success for Students

MIDLAND, Texas (KMID/KPEJ)- Midland ISD Career and Technical Education is opening doors for students to become career-ready. Animal Science is one of the four-year plan programs within CTE that high s...

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Mar 24 • 7:34 PM EDT • Science • yahoo.com
Opinion | Is the Madness of Sports Betting Here to Stay?

Students discuss the expansion of online gambling across the U.S.

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Mar 24 • 6:07 PM EDT • Sports • wsj.com
Kansas Legislature's negotiators on education bills drop sports ban tied to Christian calendar

Senate and House negotiators removed from a bill a mandate to dramatically expand periods in which schools could schedule sports activities for students.

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Mar 24 • 4:58 PM EDT • Sports • kansasreflector.com
MIT hosts its first High School Regional Science Bowl

High school teams competed in the 2026 MIT Science Bowl Invitational. The volunteer-run event is an opportunity for top students from across the country and current MIT students to connect.

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Mar 24 • 4:40 PM EDT • Science • news.mit.edu
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Students compete at Central Nebraska science fair in Kearney

Organizers said the regional competition featured 40 projects from schools across central Nebraska.

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Mar 24 • 4:25 PM EDT • Science • ksnblocal4.com
Advancing Science, Students Provide Fun and Free STEM Programs for Low-Income Youth

Alyssa Huang seriously loves science and math. And she’s on a mission to make every kid feel the same way.

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Mar 24 • 4:12 PM EDT • Science • pacificsun.com
Nancy Bostock lands support from majority of Pinellas legislative delegation

'Our students and parents deserve leaders at every level of government who will work together to put them first.'

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Mar 24 • 3:50 PM EDT • Politics • floridapolitics.com
UMaine sports management students enjoy networking trip to Indiana

Westfield’s Droplight Grand Park Sports Campus, more Indianapolis-based experiences

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Mar 24 • 2:55 PM EDT • Sports • wabi.tv
Nine Brody School of Medicine students match to ECU Health for residency training

Fourth-year medical students from the Brody School of Medicine learned where they will take on residency during Match Day.

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Mar 24 • 12:26 PM EDT • Health • ecuhealth.org
CCPS students place in 2026 science fair

Charles County Public Schools (CCPS) held the 10th annual History, Industry, Technology and Science Expo, also known as HITS, on March 21 at St. Charles High School. ​​​​​​​

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Mar 24 • 12:26 PM EDT • Science • ccboe.com
Commentary: Morristown youth sports need more coaches—here’s how to help

A student aims to match experienced athletes with youth leagues in need of coaches.

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Mar 24 • 12:06 PM EDT • Sports • morristowngreen.com
Brookdale Student Leana Vitale Turns Passion for Science into Research Success

Leana Vitale is proving that curiosity, determination, and hard work can open remarkable doors. A Brookdale student graduating this spring with two associate degrees in biology and chemistry, she has already distinguished herself as an

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Mar 24 • 10:47 AM EDT • Science • brookdalecc.edu
Inside the DOCS Community Health Leadership Conference at the Miller School of Medicine

Medical students at the Miller School lead the DOCS Community Health Leadership Conference, showcasing student‑run projects.

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Mar 24 • 10:17 AM EDT • Health • news.med.miami.edu
Why going to an HBCU might be better for Black students’ health

A study found correlation between the environment and long-term wellness in sample of 1,978 who attended college between 1940-80

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Mar 24 • 10:00 AM EDT • Health • theguardian.com
Partnership Brings Nursing Students to Front Lines of Community Health in South DeKalb

A new partnership between nursing students at Georgia State University’s Perimeter College and New Life Community Alliance creates opportunities for students to gain hands-on experience.

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Mar 24 • 9:00 AM EDT • Health • news.gsu.edu
Lessons from China—Questrom Class Took BU Students on Memorable Business Trip

Over spring break, 25 Boston University students joined Professor, Greg Stoller to see what Chinese companies could teach them

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Mar 24 • 8:47 AM EDT • Business • bu.edu
UW-Oshkosh nursing students among first to try new electronic health record platform from Epic

Thanks to a partnership with Epic, UW-Oshkosh nursing students are early adopters—among the very first to try a new electronic health record platform called Lyceum.

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Mar 24 • 8:41 AM EDT • Health • uwosh.edu
What's for Lunch? 25 Years of Inspired Science in Schools

The Sisters in Science student organization has quietly shaped young learners in Kalamazoo by presenting hands-on experiences in schools.

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Mar 24 • 8:37 AM EDT • Science • kzoo.edu
Salamander Migration Has New Citizen Science Component

Each spring, blue-spotted salamanders emerge from their underground burrows at Presque Isle Park in Marquette and venture across the road to lay their eggs. Northern Michigan University students have been involved in conservation, data collection and public education efforts for this annual event, but this year, the general public is invited to play a more active role in salamander migration research. Northern Michigan University Biology Department Head Jill Leonard encourages community members to participate in the Marquette Citizen Science Project.

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Mar 24 • 8:00 AM EDT • Science • news.nmu.edu
UGA student turns mahjong passion into growing business: Marejong

University of Georgia student Mary Dalton Dowdy started her own business, Marejong, teaching mahjong lessons in Athens, Jefferson, Watkinsville and Wrens, Georgia. She found a unique market, becoming one of

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Mar 24 • 5:00 AM EDT • Business • redandblack.com
How can you explore careers worldwide? Binghamton student founds club to find out

Binghamton University School of Management student Liam Foley discovers how connecting with diverse cultures creates new pathways for success after founding an international business club.

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Mar 23 • 8:00 PM EDT • Business • binghamton.edu
Why are the Virginia Cavaliers sports teams also called the Wahoos?

The term “Wahoos” or “Hoos” are almost exclusively used by Virginia students when referring to their athletes and fans.

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Mar 23 • 6:51 PM EDT • Sports • usatoday.com
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I was on the Air Canada flight that crashed at LaGuardia

A 22-year-old student was on an Air Canada flight that crashed at LaGuardia Airport. He described the moment of the collision and the aftermath.

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Mar 23 • 5:37 PM EDT • Business • businessinsider.com
NASA Data Hackathon Inspires Community Action

On Jan. 31, students, library staff, researchers, and community members gathered at the University of Florida’s (UF) Marston Science Library for the

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Mar 23 • 5:30 PM EDT • Science • science.nasa.gov
Chemistry student develops clear polish that turns your fingernail into a touch-screen stylus

Researchers have developed a prototype nail polish to help more people access electrically-charged touch screens.

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Mar 23 • 4:25 PM EDT • Technology • livescience.com
Babson and Microsoft Team Up to Help Small Businesses with AI  · Babson Thought & Action

Students from The Generator, Babson’s interdisciplinary AI lab, worked with small business owners to give feedback on a Microsoft AI tool.

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Mar 23 • 3:52 PM EDT • Business • entrepreneurship.babson.edu
STC HVACR student turns childhood lessons into vision for future business

Currently pursuing an associate degree in Heating, Ventilation, AC and Refrigeration (HVACR) at South Texas College, Cesar Bernal III said he was just 12 years old when he began watching his father turn determination and hard work into a small but thriving air-conditioning business in Weslaco.

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Mar 23 • 10:19 AM EDT • Business • news.southtexascollege.edu
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Bridging science and music - College of Arts and Sciences

Graduate student Briana Nave studies music's use and interactions with modern scientific medicine in the early 20th century.

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Mar 23 • 9:23 AM EDT • Science • college.unc.edu
Free sports physicals return for public school students in Flagler and Volusia counties

Thousands of middle and high school students in public schools across Volusia and Flagler counties can receive free sports physicals this spring as AdventHealth helps young athletes prepare safely for the upcoming season.

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Mar 23 • 8:00 AM EDT • Sports • adventhealth.com
Benjamin Logan students shine at Regional Science Day competition

Benjamin Logan students had a strong showing at the Ohio Academy of Science Regional Science Day at Ohio Northern University. Competing against top students from […]

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Mar 23 • 7:04 AM EDT • Science • peakofohio.com
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Rising job opportunities in sports management attract students

Kaleb Tkacs became involved in sports management from the moment he stepped foot on Duquesne University’s campus in August 2023. Tkacs, of Scottdale, joined as a volunteer film crew member with the Duquesne football team that fall. In 2024, he was elevated as a student assistant, overseeing the film crew,

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Mar 23 • 4:01 AM EDT • Sports • triblive.com
Scholar Athlete of the Week: Andra Stokes, Stevens High School

KSAT 12 Sports and CHRISTUS Children’s shine a spotlight on a local senior student athlete

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Mar 22 • 11:49 PM EDT • Sports • ksat.com
Students Learn the Science of Tree Felling at Treehaven

Click here to view this video from wjfw.com.

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Mar 22 • 11:25 PM EDT • Science • wjfw.com
UTA College of Business to connect students, professionals with networking, elevator pitch event

Students, business professionals and recruiters will mingle from 6 to 8 p.m. Monday at the UTA Center for Entrepreneurship and Technology Development.

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Mar 22 • 11:00 PM EDT • Business • theshorthorn.com
Column: Accessing mental health support shouldn’t require a walk across campus

"While well-intentioned universities have developed mental health support systems, they are poorly designed to meet students’ needs."

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Mar 22 • 9:40 PM EDT • Health • dailytarheel.com
Spring Health Fair delivers commitment to student wellness

The Student Wellness Advisory Committee hosted their annual Spring Health Fair on Friday afternoon where students were able to gain free tote bags, learn from live simulations and gain insight on new clubs and organizations centered on wellness.

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Mar 22 • 8:00 PM EDT • Health • ndsmcobserver.com
Politics, protests and popular culture: The University of Minnesota community responds to ICE impact through memes and music

Outside Coffman Union on March 3, The University of Minnesota’s Students for a Democratic Society protested Immigration and Customs Enforcement’s presence in Minnesota and on campus, despite reports that Operation...

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Mar 22 • 6:52 PM EDT • Politics • mndaily.com
Students compete in Virginia Science Olympiad State Tournament at UVA

The tournament’s events ranged from knowledge tests to building robots.

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Mar 22 • 6:22 PM EDT • Science • 29news.com
Students compete in Virginia Science Olympiad State Tournament at UVA

The tournament’s events ranged from knowledge tests to building robots.

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Mar 22 • 6:22 PM EDT • Science • whsv.com
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Student researchers bring Kentucky State University science to Posters-at-the-Capitol

With lawmakers just steps away, three Kentucky State University undergraduates presented research on cattle health, soil amendments and food safety at the Capitol Annex on March 5, bringing student-led agricultural […]

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Mar 22 • 3:00 PM EDT • Science • state-journal.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Immigration crackdown impact on local Latino-owned businesses

Latino business owners told WRAL News that fear and uncertainty following a nationwide crackdown in immigration enforcement are keeping some families out of public spaces, leaving small businesses struggling to survive. This story was written by Oriana Torre, a senior graduating journalism student at the University of Florida, participating in the CBC-UNC News Media Multiplatform Fellowship.

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Mar 22 • 1:39 PM EDT • Business • wral.com
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Oscar-Winning Alumnus Returns to Pasadena’s ArtCenter for Entertainment Design Expo

One week after winning the Academy Award for Best Animated Feature, KPop Demon Hunters co-director Chris Appelhans returns today to ArtCenter College of Design, the Pasadena campus where he studied illustration, for the college’s third annual Entertainment Design Expo. The expo, known as ENTX, opens the Hillside Campus to the public for a full day of gallery exhibitions, game playtesting, animation screenings and interactive experiences featuring work from more than 200 ArtCenter students and alumni. General admission is free with advance registration. Two industry panels — including Appelhans’s talk — require $15 tickets. Appelhans, who graduated from ArtCenter with a bachelor of fine arts in 2002, co-directed KPop Demon Hunters with Maggie Kang. The animated film, produced by Sony Pictures Animation and released on Netflix, became the streaming platform’s most-watched film in history, according to Netflix, and swept awards season with wins at the Golden Globes, the Annie Awards and the Grammys before taking the Oscar on March 15. His talk and audience Q&A is scheduled from noon to 1 p.m. in the Ahmanson Auditorium. Doors open at 11:30 a.m. The film’s ArtCenter ties extend beyond its co-director. Art director Angela Sung, cinematographer Gary H. Lee, visual development artist Celine Kim and painter Simon Baek are all ArtCenter graduates who worked on the production, according to the college. The free portions of ENTX include a concept design showcase, a production design gallery, a model gallery, a stop motion studio preview, an alumni gallery and a KPop Demon Hunters fan art gallery. Visitors can also playtest games designed by ArtCenter students. An Animation Shorts Showcase runs from 2 to 3 p.m. and includes “Boy, I’m Scared,” a capstone short by ArtCenter graduate Lindsey Tenaglia that was named a semifinalist for the 2025 Student Academy Awards in the animation category. Also screening

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Mar 22 • 8:30 AM EDT • Entertainment • pasadenanow.com
UF students celebrate ‘women supporting women’ through new mental health group

According to the Healthy Minds Network’s data interface, a little more than one in three female college students suffered from anxiety in 2025, compared to a little under one in four male students.

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Mar 22 • 8:00 AM EDT • Health • alligator.org
See what students from New Hampstead High wore for their 2026 prom

Students from New Hampstead celebrate their 2026 high school prom at Red Gate Farms.

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Mar 22 • 5:29 AM EDT • Entertainment • savannahnow.com
‘The best course I've taught’: Duquesne business students, faculty volunteer to help with taxes

After hearing in 2018 about a way to help low- to middle-income individuals and families with preparing their tax returns, Amy Yurko, now an associate...

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Mar 22 • 4:00 AM EDT • Business • post-gazette.com
Urban Entertainment Society crowns this year’s Beat Battle champion

The Urban Entertainment Society hosted its annual Beat Battle at the Chris Young Cafe on Friday, highlighting talented students across every major.

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Mar 21 • 7:47 PM EDT • Entertainment • mtsusidelines.com
47th annual Utica University science fair shows area students are smarter than ever

Four dozen science projects from 60 students from eight area schools competed for the top prizes at the Donohue Concourse underneath the Frank Gannett Library. Some of the topics may have changed over the years — there were no baking soda volcanoes — but the students still displayed their projects on decorated posterboard for staff, family and the judges to see. The projects were split between the junior division — 7th and 8th grades — and the senior division — 9th through 12th grades.

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Mar 21 • 5:00 PM EDT • Science • romesentinel.com
'American people long for civility,' former VP Pence tells University of Tennessee students

In a frank discussion about America's future. Pence says \

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Mar 21 • 4:58 PM EDT • Politics • knoxnews.com
Scientists Recruit Undergrad to Step Into Room Filled With Ravenous Mosquitoes for “Full-Body Massacre”

Researchers at Georgia Tech used undergraduate student Chris Zuo as bait in trials to study mosquito flight behaviors.

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Mar 21 • 2:00 PM EDT • Science • futurism.com
Local Business Spotlight: Educational Foundation of AACPS

The Education Foundation of Anne Arundel County Public Schools is helping bridge gaps, support innovation, and create new opportunities for students and educators throughout the county. In this wee…

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Mar 21 • 12:00 PM EDT • Business • eyeonannapolis.net
TAMIU planetarium reopens after major renovations

TAMIU celebrated the reopening of its renovated planetarium, now featuring advanced technology and a new immersive learning experience for students and visitors.

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Mar 21 • 9:02 AM EDT • Science • lmtonline.com
How the US Is Squandering Its Science and Technology Advantage

The Trump administration’s cuts to research and development (R&D) and opposition to international student visas will have disastrous effects on US technological competition with China.

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Mar 21 • 3:05 AM EDT • Science • nationalinterest.org
College student asks Trump’s UN Ambassador: How is a war half a world away, funded by my taxes, helping
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Mar 20 • 10:44 PM EDT • Politics • cnn.com
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California Health Sciences University medical student celebrates full-circle moment on Match Day

Friday was a big day for medical students across the country. It's Match Day.

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Mar 20 • 9:30 PM EDT • Health • abc30.com
Charleston Waterkeeper opens Community Science Lab for researching water quality, monitoring microplastics

CHARLESTON, S.C. (WBCD) — Charleston Waterkeeper has opened a first-of-its-kind Community Science Lab, inviting residents, students, and volunteers to take a hands-on role in monitoring Lowcountry wat...

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Mar 20 • 2:13 PM EDT • Science • yahoo.com
Apple Announces New Mac Sales Record Following MacBook Neo Launch

Apple's CEO Tim Cook today said the Mac just had its "best launch week ever for first-time Mac customers," which suggests that the new MacBook Neo has been a hit with customers buying their first laptops or switching from Windows. Apple released the MacBook Neo last Wednesday, March 11. In the U.S., pricing starts at just $599 for the general public and an even lower $499 for college students.

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Mar 20 • 9:14 AM EDT • Technology • macrumors.com
A clarinetist, a high school student, and some climate deniers write a science paper

With the help of AI, misinformation purveyors are up to new tricks.

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Mar 20 • 7:00 AM EDT • Science • motherjones.com
Researcher: Addressing runaway college sports spending in Virginia

This whole college sports enterprise is business development that is being financed by student subsidies, and frequently ever higher student loan debt. As a society, do we do this for any other fo…

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Mar 20 • 4:00 AM EDT • Sports • cardinalnews.org
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Yale Surgery Launches Health Career Collaborative–New Haven to Mentor Local High School Students

The Department of Surgery has launched the Health Career Collaborative (HCC)–New Haven, a mentorship program connecting local high school students with surgeons

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Mar 20 • 12:00 AM EDT • Health • medicine.yale.edu
Treasury Department to take over some federal student loans, as Trump administration works to dismantle Education Department

The Treasury Department will begin to manage federal student loans in default, taking on a key function of the Education Department as the Trump administration further pushes to dismantle it.

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Mar 19 • 8:17 PM EDT • Politics • cnn.com
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New dispute emerges around Subnautica 2’s early access release

Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.

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Mar 19 • 5:28 PM EDT • Technology • gamefile.news
By studying muscle function, student aims to improve others’ physical health—and maybe his own | Harvard T.H. Chan School of Public Health

Sam Lapp, PhD ’26, delves deep into the biology of how muscles work.

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Mar 19 • 1:50 PM EDT • Health • hsph.harvard.edu
University of Montevallo’s Stephens College of Business Sales Team Earns Top Finish at National “Selling with the Bulls” Competition

The University of Montevallo’s Stephens College of Business Sales Team earned a fourth-place overall finish in Flight 2 at the prestigious Selling with the Bulls Intercollegiate Sales Competition, hosted by the University of South Florida Muma College of Business. Widely regarded as the “toughest test in sales education,” the competition featured 168 student competitors representing… Continue reading University of Montevallo’s Stephens College of Business Sales Team Earns Top Finish at National “Selling with the Bulls” Competition

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Mar 19 • 9:19 AM EDT • Business • montevallo.edu
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Science stars at special UChicago, Argonne screening of ‘Project Hail Mary’

Researchers and students marked the new film with a panel discussion, hands-on science demos and a shared love of discovery

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Mar 19 • 8:00 AM EDT • Science • news.uchicago.edu
Cycle Nova: Villanova students unite to honor a legacy and advance heart health

Villanova, Pa., March 17, 2026 — Beat for Good, Villanova University’s student‑run organization dedicated to supporting individuals and families affected by cardiovascular disease, hosted its inaugural cycling fundraiser, Cycle Nova, on Saturday, March...

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Mar 19 • 8:00 AM EDT • Health • newsroom.heart.org
High School Students Present Ideas to St. John’s Experts in Tobin Business Plan Competition

Area high school students brought their business visions to St.

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Mar 19 • 8:00 AM EDT • Business • stjohns.edu
A public health professor is bringing the National Bioethics Bowl to Pitt

The competition, organized this year by Cindy McCarthy, gives students a chance to consider challenging questions about health and technology.

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Mar 19 • 8:00 AM EDT • Health • pittwire.pitt.edu
A clarinetist, a high school student, and four climate deniers write a science paper, with a little help from AI…

Papers like this are like kindling for anyone 'just asking questions' about climate change, or 'doing their own research,' stoking the flames of climate denial.

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Mar 19 • 6:00 AM EDT • Science • thebulletin.org
Rats, gnats and Yik Yak. Queens University responds to dining health concerns

The university received a lackluster health inspection in January and an improved one in February before other student concerns emerged.

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Mar 19 • 5:00 AM EDT • Health • charlotteobserver.com
25 Years of Courage and Curiosity: Sally Ride Science at UC San Diego Division of Extended Studies

Celebrating 25 years, Sally Ride Science at UC San Diego inspires students, educators, and families with hands-on STEAM programs that spark curiosity and confidence.

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Mar 18 • 8:00 PM EDT • Science • today.ucsd.edu
Keweenaw Bay Ojibwa Community College students engage with science in new laboratory

Previously, students did not have a lab and had to take courses digitally.

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Mar 18 • 7:08 PM EDT • Science • uppermichiganssource.com
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Alumna supports students through sports

Alumna Chrystal Starling has built a dynamic career combining sports, education, and youth development. From Hokie student athlete to professional basketball player to assistant principal at a New York charter school, Starling credits writing and the influence of Nikki Giovanni for helping her find her voice and her purpose.

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Mar 18 • 7:02 PM EDT • Sports • news.vt.edu
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