SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " e9 " 27,080 found 🔀 AI-powered Shuffle
Packers Lose Defensive Captain Just Before Massive Showdown With Lions
Green Bay Packers defensive captain Zaire Franklin has been ruled out against the Detroit Lions, leaving Green Bay without both starting linebackers.
How Nathan Fielder's cringe-comedy career led him to Elizabeth Holmes
Spoiler alert! We're discussing the themes and structure of the Elizabeth Holmes documentary "You Can See Everything" and touching on a surprising aspect of its second half, so turn away if you want to go in completely cold.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Who can buy California's voter rolls and why?
Chris Micheli, an adjunct professor at McGeorge School of Law and longtime lobbyist, explained who is able to buy the voter rolls and why in an interview on California Politics 360.
South Texas Health System (@stxhealthsystem)
1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".
Cam Skattebo Update: Will Giants Star RB Play Against Texans?
New York Giants share news on RB Cam Skattebo after benching in Week 6. The post Cam Skattebo Update: Will Giants Star RB Play Against Texans? appeared first on HEAVY.
Robinson, Baker have tough talk about the offense
Robinson, Baker have tough talk about the offense
Seattle Mariners Rumors: Zach Neto Gaining Traction as Possible Target
The M's certainly have a need for what Neto can provide.
Babcock Singles Out Oiler After Ugly Loss To Maple Leafs.
Mike Babcock called out one player in particular after a 7 - 2 thrashing against the Leafs.
Preview
The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...
After long, strange trip, Compass CEO nears launch of psilocybin pill
Compass Pathways is on the cusp of FDA approval for a proprietary version of psilocybin — the active drug in magic mushrooms.
Silicon Valley software engineer pay ranked against other US cities
Bay Area software engineers retain a 53% pay premium after adjusting for local prices, Levels.fyi found. Taxes aren't included.
Opinion - How Trump learned to stop worrying and love space science
He recognizes a cool thing when he sees it.
Inside California Politics: State Senate candidate John Erickson
(Inside California Politics) — California’s top-two primary system often leads to same-party general election races, often between two Democrats, and this year is no exception. Two weeks ago on Inside...
Manchester United vs Bournemouth: Live updates from Old Trafford
Under-fire Manchester United manager Michael Carrick is under enormous pressure heading into today’s Premier League clash with Bournemouth on the back of a seven-game run without a win.The boss has ...
"Jakucionis, he's family. He's an incredible player," …
"Jakucionis, he's family. He's an incredible player," …
Maliek Collins agrees to terms on contract extension
Maliek Collins to remain in Cleveland for two additional years
Health board still paying for research despite criticism over patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
Saints vs. Steelers in Paris: Week 7 game chat
The Saints face the Steelers in this Week 7 matchup. Join us here for the game!
NH's Business: Healthcare affordability for NH residents
Fred Kocher sits down with Maria Proulx with Anthem Blue Cross, Blue Shield to talk about healthcare affordability for NH residents.
Open Thread, Sunday, October 25: How we doing today, folks?
Your daily source for off topic chatter with the MMA Mania faithful.
Full injury report for Sunday's Clippers vs. Thunder matchup
Full injury report for Sunday's LA Clippers vs. Oklahoma City Thunder matchup.
Guardians Middle Infielder is a Prime Trade Candidate
The Cleveland Guardians, fresh off an ALCS appearance, will be facing several tough decisions next season regarding their lineup. The 85-win team won their division and looks poised to repeat next year, but they face an enviable dilemma. What do they do with their influx of top, young talent, and how do they find them …
Pair of CBs Lead Steelers Inactives vs. Saints
Terell Smith will have to wait to make his Pittsburgh Steelers debut for at least another week. The fourth-year cornerback, […]
Pat Surtain II unlikely to play
Pat Surtain has good chance to suit up in Week 8 due to ankle injury
2026 Vanderbilt Football Mailbag #9: Call For Submissions
Post VANDERBILT Football and/or SEC Football questions in the comments here. It’s becoming more and more obvious we’re highly unlikely to win another game this season. Our defensive calls make no sense, we’ve got an uber-talented but uber-raw QB learning on the jerb, and Barton Simmons’ decision to staff our O-Line exclusively with matadors has […]
McMillan backs Coombes after groin grab allegation
Munster head coach Clayton McMillan backs Gavin Coombes after the back row alleged he had been grabbed in the groin in Saturday's defeat by Leinster.
🚨 Barça's squad to face Real Madrid
Barcelona have just announced Hansi Flick's squad for tonight's Clásico against Real Madrid at the Spotify Camp Nou. Midfielder Orian Goren is the standout inclusion in Flick's 23-man squad. Reserve-...
Sources: Leeds hit by new hurdle in Nicolo Tresoldi race
Daniel Farke in a press conference with Leeds, with Paraag Marathe at Elland Road
What analysts are watching in the Texas Senate race, CBS News political experts weigh in
The top 25 classic golf courses in Canada, ranked
We rank the best courses built in Canada before 1960.
Seamus Power, Austin Smotherman Share Lead In Windy Bermuda Showdown
Seamus Power and Austin Smotherman share the Bermuda Championship lead at 16 under, with fierce winds and PGA Tour playing privileges adding drama to Sunday's finale.
Utah Jazz Must Let Darryn Peterson Feel the Pressure
Shielding Utah’s prized rookie from high-stakes moments only stunts his growth. To secure their future, the Jazz must force Darryn Peterson to embrace the game-deciding pressure now.
Texas A&M Defense Folds Again As Alabama Exposes Aggies In Late Collapse
Texas A&M's defense surrendered 311 passing yards and two fourth-quarter touchdowns in a 31-20 loss to Alabama, raising more questions about Mike Elko's Aggies.
Scientists Trapped an Antimatter Particle for Months to Study Its Secrets
These elusive and reactive particles have been challenging to hold on to and even more challenging to study, but a new method paves the way for tests on the differences between matter and antimatter.
This Week in Purple: Around The World (Series)
Colorado Rockies news and links for Sunday, October 25th, 2026
Patriots rooting guide for NFL Week 7
Rooting information, kickoff times, TV schedule and more for NFL Week 7.
Five new businesses coming to Hunt Valley Exchange, including Dunkin’ and indoor golf simulator
Five businesses are coming to Hunt Valley Exchange in northern Baltimore County, including a Dunkin’, indoor golf simulator studio, Indian restaurant and wine and spirits store.
Game status update for Browns CB Denzel Ward against Titans
Cleveland gets an update on the status of their top cornerback.
Browns Week 7 fantasy start-sit: Boston, Judkins, Fannin, Concepcion
Tennessee has allowed the 10th-most half-PPR points to receivers, while Dylan Sampson’s return from injured reserve threatens Quinshon Judkins’ receiving work.
Knoebels’ Hallo-Fun brings Halloween rides, treats and entertainment
FOX56 WOLF TV carries news, sports, weather and coverage of local events in the Wilkes-Barre, Pennsylvania area, including Mountain Top, Plymouth, Nanticoke, Kingston, Back Mountain, Scranton, Moosic, Pittston, Avoca, Edwardsville, Hilldale, Wyoming, Laflin, Yatesville, Pittston, Dupont, Sugar Notch, Korn Krest, Warrior Run and Larksville.
'Multwoh' becomes highest-grossing film of CinePanalo
'Multwoh,' a queer romance-horror film, has become the highest-grossing film to emerge from the Puregold CinePanalo Film Festival, the film’s team said Sunday.
Women's FA Cup clash against Rotherham United postponed
Following a pitch inspection at the BD Community Stadium, this afternoon's First Round Women's FA Cup clash between Leeds United Women and Rotherham United Women has been postponed.An update on the re...
NFL Week 7 expert picks, predictions: Moneyline, against the spread
A look at our expert picks for Week 7 of the 2026 NFL season.
Amorim eyes raid on Manchester United for £52m defender
Ruben Amorim is keen on a reunion with Manchester United defender Leny Yoro at AC Milan.The Serie A side are weighing up a move for the 20-year-old at the end of the season, according to reports in It...
WSL: Crystal Palace host Chelsea in first of five games
Follow live coverage of Crystal Palace host Chelsea in the first of five Women's Super League games on Sunday.
Takeaways from Colorado's disastrous 57-24 loss to Oklahoma State
Oklahoma State fell to Colorado after an abysmal second-half collapse. Here are five takeaways from the Buffaloes' fifth straight loss.
Updated SEC football conference standings following Week 8 upsets
The SEC's Week 8 slate produced a number of notable results. Here is how those results impacted the conference standings entering Week 9.
CBS News political experts weigh in on Texas Senate race halfway through early voting
The latest CBS News poll showed Talarico leading 51% to 49%, well within the margin for error.
Marcos Leonardo Opens Up On A Difficult Start At Ajax
Following Ajax's win against Atalanta, Marcos Leonardo spoke about a difficult start at Ajax.
Skeleton Festival returns with ghosts, superheroes and family fun
Downtown Harrisonburg was covered with fantasy creatures like dragons, superheroes and princesses Saturday afternoon during the annual Skeleton Festival.
How to Watch: Arizona Cardinals vs. Denver Broncos
Everything you need to know about the Arizona Cardinals game against the Denver Broncos.
AP Exclusive: Trump’s border chief defends wall plans in Texas’ Big Bend despite a court setback
The Trump administration's top border official is defending plans to build a wall in Texas' Big Bend region. Customs and Border Protection Commissioner Rodney Scott argues the entire $46 billion
Los Angeles Rams vs. Las Vegas Raiders: How to watch the NFL Week 7 game, channel, streaming info and more
Is it rude to keep the airplane window shades open?
In this Sunday edition of Business Insider Today, we're breaking down the flight etiquette debate that's dividing the internet.
Udinese vs AC Milan – Match preview and team news
AC Milan will aim to get inside the top four of the Serie A league table by securing all three points when they meet Udinese on Sunday away from home in their next match.Udinese vs AC Milan – Match...
YouTube Gold: Highlights From Louisville’s Trip To Kansas
Kansas lost Wednesday, but the Jayhawks are not exactly pushovers
18 Once-Common Things That Quietly Vanished From Our Lives
"I texted one of those numbers on the TV to buy a ringtone back then. Good times. Then smartphones came around, and I've kept my phone on vibrate for over 13 years now."
Are the Bills playing today? NFL Week 7 schedule, next game, AFC East standings
The Buffalo Bills and star QB Josh Allen are off to a terrific start to the 2026 NFL season. Here's what's on deck for the team in Week 7.
That Ramaswamy ad is repugnant. And it will eventually be seen as a gift to Trump
If Ramaswamy goes down, Trump will spin it that Democrats and the corrupt media misrepresented the ad and lied about Ramaswamy.
New York Giants vs. Houston Texans: How to watch the NFL Week 7 game, channel, streaming info and more
Voters in 2 Democratic strongholds could ban transgender girls from girls school sports
Reliably Democratic Colorado and Washington have ballot measures that would bar transgender girls from some sports competitions
Swapping horses for ninja warriors: The Olympic sport undergoing massive change
Several Olympic sports have evolved over the years to keep up with an ever-changing landscape, but few have been as drastic as the Modern Pentathlon.
"If they are Nuggets fans, they should support us," …
"If they are Nuggets fans, they should support us," …
“I’m not making this game about the officials so …
“I’m not making this game about the officials so …
Norman Powell: "I feel like this is another …
Norman Powell: "I feel like this is another …
Inside Victoria's Secret's $6 billion business turnaround
Victoria's Secret is in the midst of a comeback, with sales surging and its stock on track to notch its best year ever.
Dana White Praises Merab Dvalishvili After UFC 333
UFC president Dana White praised bantamweight fighter Merab Dvalishvili following his fight against Petr Yan at UFC 333.In the trilogy championship bout between Yan and Dvalishvili, the two long-time rivals went the full 25 minutes and put on an absolute show as they went back and forth for five rounds before Yan ultimately edged out […] The post Dana White Praises Merab Dvalishvili After UFC 333 appeared first on HEAVY.
Liverpool committing to Barcelona model, massive change for club
Liverpool are committing to the Barcelona model. It's a massive change for the club - but will it pay off?Liverpool have a transfer strategy under Jurgen Klopp and it was a wildly successful one. They...
Bayern bosses offer differing assessments of Lennart Karl’s development
Bayern Munich honorary president and supervisory board member Uli Hoeneß has spoken strongly about Lennart Karl, insisting that the highly rated youngster is still far from being a superstar. In an i...
Vikings Handed Realistic Trade Idea for Colts’ Jonathan Taylor
The Minnesota Vikings are one of the potential trade destinations in the speculation conversation regarding Indianapolis Colts running back Jonathan Taylor. Moreover, the Vikings could push the Colts to become sellers if they defeat them in Week 7.If Minnesota does move to 6-0 and pushes the Colts to put up a “For Sale” sign on […] The post Vikings Handed Realistic Trade Idea for Colts’ Jonathan Taylor appeared first on HEAVY.
Where to watch Kansas vs. Duke basketball: Channel, live stream, time, TV schedule for men's exhibition game
It's a preseason matchup of blue bloods as Duke visits Kansas on Sunday. Here's when and where to tune in.
Everything’s the Best: Reason to Believe
With more than 10 matches in all competitions played, are we finally starting to see the promise of Isak and Wirtz?
Deion Sanders Forced to Turn to 5th Different QB Since Son Shedeur’s Exit as Colorado’s Offensive Struggles Hit All-Time Low
Deion Sanders traveled to Stillwater searching for answers under center. Instead, Colorado’s heavy 57-24 loss to Oklahoma State exposed a deeper crisis.
Browns sign Maliek Collins to $30 million extension
The Cleveland Browns have secured one of their standout defensive players for the future before their next game against the Tennessee Titans . Cleveland defensive tackle Maliek Collins has agreed to a two-year contract extension worth $30 million. According to NFL insider Ian Rapoport, Collins’ agent, Drew Rosenhaus, confirmed the agreement to him […] The post Browns sign Maliek Collins to $30 million extension appeared first on ClutchPoints.
Argentina should host World Cup
SPAIN are a coming force in world rugby and I welcome their bid to host the World Cup. However I think Argentina should win the vote as they have been a true force on the world stage for a long time. It would be ground breaking to take the event to South America. Either bid […] The post Argentina should host World Cup appeared first on The Rugby Paper .
Inter Milan vs Fiorentina – Predicted lineup and team news
Inter Milan welcome Fiorentina to the San Siro on Sunday for their next Serie A game, aiming to climb to the summit of the table.The Nerazzurri arrive in outstanding domestic form, having avoided defe...
Health screening event held in honor of Colin Hill
A health screening was held Saturday at McCluer High School in honor of 14-year-old Colin Hill, who died from an undiagnosed heart condition.
Five takeaways from USC’s embarrassing 24-7 loss to Wisconsin
What did we learn from the Trojans’ pathetic performance in Madison Saturday evening?
Barcelona vs Real Madrid, La Liga: Preview
The biggest game in the game, with a whole lot at stake
READERS' CHOICE | Impact Realty Group makes its mark with Best Small Business win
A locally owned and operated real estate brokerage has been named Best Small Business in the 2026 Texarkana Gazette Readers' Choice Awards.
Bethune-Cookman scores wild upset victory over Jackson State
The 2026 football season has delivered upsets and stunning losses, but this one might be the most shocking. Over the past two seasons, Bethune-Cookman has gained momentum as a formidable SWAC East contender, but it needed a definitive win over one of the conference’s top teams to prove its worth . Today, that victory came. Bethune-Cookman secured a […] The post Bethune-Cookman scores wild upset victory over Jackson State appeared first on ClutchPoints.
Jacksonville Jaguars’ Major Offensive Issue After 4-2 Start Revealed
The Jacksonville Jaguars’ 4-2 start has been overshadowed by a recurring offensive problem, as penalties continue to erase scoring opportunities and disrupt drives. Costly infractions have prevented the team from maximizing its production, raising concerns about discipline as Jacksonville looks to remain competitive in the AFC. The Jaguars have already had three touchdowns wiped off […] The post Jacksonville Jaguars’ Major Offensive Issue After 4-2 Start Revealed appeared first on Gridiron Heroi
Vikings sign defender days after his release from the Giants
The Vikings brought back a familiar defender after the Giants released him.
Prediction For Buccaneers’ Must-Win Game Against Panthers
The Buccaneers must find a way to earn a win over the Panthers this week. Will they get it?
NO LOVE? South Florida Seemingly Shuns the Miami Marlins
It's a sad state of affairs when the city's MLB team might be the sixth-most popular team in their own hometown
Indiana high school girls soccer state championship schedule, semistate results
Here is the full schedule and pairings for the Indiana high school girls soccer state championship round on Saturday.
Bell County early voting reaches 42,964 ballots through Saturday
Bell County voters cast 7,523 ballots on Saturday, Oct. 24, pushing the cumulative early voting turnout to 42,964 through the first six days of voting.
Steph Curry's brother is already calling out Warriors center woes
The former Warrior couldn't help but point out the glaring roster issue.
Lamar dominates second half to end Houston Christian's winning streak
Lamar took control of a close game in the second half to deny Houston Christian its third consecutive win.
Should the Baltimore Orioles Target Steven Kwan?
The Baltimore Orioles could acquire Steven Kwan this offseason.
On the agenda: Chevron health risk findings, gun violence study and 23rd Street safety
The Richmond City Council meets Tuesday, October 27, to hear the Bay Area Air District's health risk assessment of the Chevron refinery, consider competing traffic safety proposals after two pedestrian deaths on 23rd Street, and hear a presentation about the city's Office of Neighborhood Safety. A special meeting
What We Learned About Gophers in Defensive Showdown vs Iowa
Floyd of Rosedale was on the line Saturday, and the Minnesota Gophers needed their defense to carry the load against Iowa.
Barack Obama rallies Michigan crowd for El-Sayed, saying he’s ‘fighting for real change’
Former president speaks to rapturous crowd of thousands in support of Democrat Abdul El-Sayed for US Senate