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White Sox Minor League Update: September 8, 2026
Three teams, two walk-offs, one perfect night
Allegheny County Council proposes bill that could regulate AI use in political campaign materials
Members of Allegheny County Council on Tuesday introduced a bill that would require political candidates to disclose their use of artificial intelligence in campaign materials, an effort aimed at preventing voters from being misled by AI-generative content. If passed, the ordinance would establish disclosure requirements for AI-generated campaign content used
ESPN insider reveals receive shocking, Warriors’ Jimmy Butler health update
The NBA season is rapidly approaching as teams are expected to report to training camp at the end of the month.
From climate change to the economy to healthcare, NH voters seek solutions with their ballots
Scott Thompson, a retired mechanic from Epsom, usually doesn’t vote in midterm elections, but after a GOP candidate for state representative showed up at his door he decided to make plans to vote on Tuesday.
Detroit Lions Receive Several Major Updates Ahead of Week 1
The Detroit Lions received several major updates ahead of Week 1, including encouraging injury news, a key roster decision, and an intriguing offensive line battle.
New Apple CEO to face first test with foldable iPhone launch
Apple is expected to unveil a slew of new and updated devices, including a long-rumored foldable iPhone, when it holds its annual late-summer hardware event on Wednesday in Cupertino, California.The tech giant is expected to finally reveal a long-awaited foldable iPhone, currently rumored to be called the iPhone Ultra, which will start at $2,000, according to reports.
Persona 6 and Persona 4 Revival Steam achievements surface [Update: More games leaked]
Steam Achievement lists for Persona 6 and Persona 4 Revival have surfaced on Exophase, a site that specializes in trophy and achievement tracking.
Man accused of assault, inducing panic at Dr. Amy Acton event pleads not guilty
The armed Ohio man investigators said set off a security scare involving Democratic gubernatorial candidate Dr. Amy Acton pleaded not guilty in court Tuesday.
49ers catching early breaks — including avoiding Rams’ Aaron Donald
Kyle Shanahan went out of his way to avoid providing injury updates after the 49ers’ first practice in Australia, cleverly pointing out that they were a full day ahead of...
Halo composer Marty O’Donnell takes Nevada race to RNC stage
Nevada congressional candidate and “Halo” composer Marty O’Donnell will speak at the RNC’s Dallas midterm convention as he challenges Rep. Susie Lee.
COVID-19 infections rise across California as health officials urge vaccinations
California health officials are encouraging residents to stay up to date on COVID-19 vaccinations as infections increase statewide.
US Open results 2026: Quarterfinal scores and semifinal bracket updates
US Open results and bracket updates for the 2026 men’s and women’s draws.
Dodgers replace Shohei Ohtani with Freddie Freeman for Reds game
The Los Angeles Dodgers changed Freddie Freeman's role after an update on Shohei Ohtani.
Should political candidates have more security?
COLUMBUS, Ohio (WCMH) — The man accused of trying to attack Ohio gubernatorial candidate Dr. Amy Acton appeared in court for the first time Tuesday. Patrick Havas, 38 of Canfield, faces assau…
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Alaska review finds potential financial disclosure issues involving 91 candidates
A preliminary Alaska Department of Law review found potential financial disclosure discrepancies involving 91 candidates, but did not determine whether any laws were violated.
Michigan rabbis lay out demands for El-Sayed and state Democrats to earn their votes
As the candidate seeks Jewish voters, an open letter describes Jewish sovereignty in Israel and Jewish safety as “nonnegotiables.”
Patriots RB TreVeyon Henderson Receives Disappointing Week 1 Update
The New England Patriots have released an injury update for running back TreVeyon Henderson ahead of Week 1.
Reflecting on Josh Allen’s career to date against the Texans
Houston has not been kind to Josh Allen
Pritzker-backed PAC plans to bankroll anti-Trump candidates nationwide
The committee, called “Ready for the Fight” in reference to a line from Pritzker campaign speeches, launched today.
Rosanne Cash postpones tour dates following medical emergency
Singer-songwriter Rosanne Cash has postponed upcoming concert dates in Wyoming and Montana following a medical emergency under doctor's orders.
Democratic socialist candidates stirred the primary election pot. But can they win in November?
An MSU Denver political expert discusses what’s behind their emergence, what they stand for and whether they can achieve lasting impact.
TRUE Community Credit Union Highlights Business Services
Airdate: September 8th, 2026 TRUE Community Credit Union Highlights Business ServicesSeptember 8, 2026Purple Rose Theatre to Present World Premiere by Devin ScillianSeptember 8, 2026Dr. Grant Brown on Autumn Vaccine RecommendationsSeptember 8, 2026Silver Maples of Chelsea Hosting Jackson Art Association Member ShowcaseSeptember 8, 2026Jackson County Genealogical Society Hosting Cemetery TourSeptember 8, 2026Otterbein SeniorLife Jackson Dedication &…
Apple Releases Firmware Update for 140W USB-C Power Adapter
Apple today released a firmware update (version 1.4.90) for its 140W USB-C Power Adapter. It is unclear what is included in the latest firmware, as Apple does not publish release notes for this. The update will be installed automatically over time when the power adapter is plugged in and connected to a Mac or other device. The update will be installed automatically over time when the power adapter is plugged in and connected to a Mac or other device.
Porto vs Manchester City Match: Champions League Live Updates
Porto hosts Manchester City at the Estádio do Dragão on Tuesday, September 8, in the opening round of the 2026-27 UEFA Champions League phase. Both teams enter the European opener in strong domestic form and will be looking to start their Champions League campaigns with a positive result. Kickoff is scheduled for 8 p.m. BST, […] The post Porto vs Manchester City Match: Champions League Live Updates appeared first on HEAVY.
Joe Biden shares health update after prostate cancer diagnosis while issuing warning to others
Joe Biden revealed his radiation treatment from last fall "worked as intended" as he urged men to discuss prostate cancer screening with their doctors.
Gymnastics, fitness and range of motion: See 4 health-focused business updates in Spring-Klein
There are several health-focused businesses that recently opened or plan to open in the Spring area.
Dario Russo's 'The Fox' Acquired By Aura Entertainment For Theaters
Aura Entertainment has acquired Dario Russo's 'The Fox,' starring Sam Neill, Olivia Colman & more with a theatrical release date set in December.
Mapping the Global Health Landscape: Analysis of Fourteen International Organizations
The global health architecture includes a number of diverse international organizations with different mandates, governance models, financing structures, and operational approaches. This KFF resource looks across a range of variables to provide a descriptive mapping of 14 key global health and related international institutions. It is intended to inform discussions about synergies and coordination, duplication, comparative advantage, shared challenges, and architectural reform.
Meet the Candidate: Ben Ivey seeks 120th District Judge seat
The El Paso Times sent questionnaires to candidates in the 2026 Nov. 3 General Election. Here are answers from 120th District Court judge candidate Ben Ivey.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Government land-grab agenda hits key Senate race as Dem backs property takeovers echoing Mamdani
Maine Senate candidate Troy Jackson suggested the state should take over mobile home parks, echoing NYC Mayor Zohran Mamdani's housing agenda.
Sonos just launched ‘Sonos 27’ app update, here’s what’s new
Last week Sonos unveiled several new features coming soon, and now the first of those upgrades are here in the ‘Sonos 27’ app update.
Berman campaign: “We’re going fishing” – ER nurse and Democrat Mitchell Berman launches first ad of general election in Wisconsin’s First District Congressional race
Spot features Berman fishing and focuses on ending corruption in Washington, contrasting Berman’s working class background and Republican Bryan Steil’s corporate special interests RAYMOND, Wis. — Today, Mitchell Berman, ER nurse and Democratic candidate for Wisconsin’s First Congressional District, launched...
Luke Fickell Updates Badgers' O-Line Health, Evaluates Week 1 Performance
Wisconsin's head coach provided health updates and an evaluation of his offensive front.
Israel to mandate Iodine in table salt amid widespread deficiency
Studies have found widespread iodine deficiency in Israel, particularly among pregnant women and children. The condition can cause thyroid problems and, in severe cases, developmental and neurological damage
Microsoft September 2026 Patch Tuesday fixes 966 flaws, 2 zero-days
Today is Microsoft's September 2026 Patch Tuesday, with security updates released for a record-breaking 966 flaws, including two actively exploited zero-day vulnerabilities.
Funding cuts are forcing dozens of health clinics in Sudan to close, aid groups warn
Aid groups say three dozen health facilities in Sudan are closing this year due to global aid cuts
After RFK visit, board members seek new policy to keep politics out of schools
Board members look to update rules about what level of politicking should be allowed in schools.
Apple Releases iOS 26.6.2
Apple today released iOS 26.6.2 with a fix for "an issue that prevents downloading a software update over a cellular connection". The minor software update is rolling out now for the iPhone 11 series and newer. To update your iPhone, open the Settings app and tap on General → Software Update. It might take a few minutes until the update is visible to everyone. iOS 26.6.2 arrives approximately three weeks after iOS 26.6.1, which delivered security fixes.
Strengthening Global Health Systems: Jeanna Holtz (’79), Nutrition & Exercise Physiology
When Jeanna Holtz, Nutrition and Exercise Physiology alum, updated her estate plans, she found herself returning to the place where her journey began: Washington State University.
Stevie Wonder announces fall tour
DETROIT — Motown icon Stevie Wonder has announced fall tour dates, including a pair of concerts at Detroit's Fox Theatre. The tour marks the 50th anniversary of his 18th studio
Apple releases iOS 26.6.2 for iPhone, here’s what’s new
On the eve of its big iPhone launch event, Apple has just released a new iOS 26.6.2 software update for...
Gov. Gavin Newsom's former chief of staff seeks to delay sentencing because of health issues
Dana Williamson, Newsom's onetime chief of staff, is seeking to delay her sentencing date for political corruption because of health issues, according to documents.
Is Trump’s midterm convention a flop before the doors even open?
Trump says he wants to energize Republican candidates before the midterms. Dozens are keeping their distance anyway.
Dan Campbell Gives Kerby Joseph Update Ahead of Week 1
Kerby Joseph has returned to the Detroit Lions facility as he continues recovering from the knee injury that ended his 2025 season.
Penn State HC Provides Two Injury Updates Before Temple Game
Penn State head coach Matt Campbell has revealed two injury updates ahead of Week 2.
Kansas City psychiatrist explores the science behind high emotional sensitivity
Dr. Sasha Hamdani's new book, "Too Sensitive," aims to provide a science-backed, empathetic framework for understanding why some people experience high emotional sensitivity. The Kansas City psychiatrist joined KCUR's Up To Date on Tuesday.
What to watch as Republicans gather in Dallas for Trump's unusual midterm convention
President Donald Trump and thousands are expected to arrive in Dallas this week. What to know about candidates, road closures and security
Liverpool’s hunt for a new sporting director: Julian Ward and the standout internal options
FSG president Mike Gordon is leading the search for Richard Hughes' replacement, with both internal and external candidates being considered
Sony is reportedly preparing a big update for the PS5 and PS5 Pro with improvements to PSSR 2.0 upscaling
Sony is reportedly getting ready to release a major new system update for the PS5, with firmware version 14.0 currently is beta.
Updated NFL Conference Championship odds entering 2026-27 season
Here's an updated AFC and NFC Championship odds entering the 2026 NFL season.
Chrome is now shipping updates every 2 weeks as AI changes the security landscape
Google is speeding up Chrome’s release schedule to ship security patches and new features faster.
‘Democrats Are Behind’: PAC Wants Party to Catch Up on A.I.
The group is starting with more than $10 million and says it intends to support midterm House candidates in swing states.
AMID POLITICAL AD BOMBARDMENT, SAUSAGE DECLARES ITS CANDIDACY… FOR DINNER
As political advertising floods screens, phones and mailboxes ahead of the 2026 midterm elections, Johnsonville is entering the race for Dinner 2026 with a candidate of its own: Sausage. Backed by new research commissioned by Johnsonville suggesting Americans are overwhelmed by both politics and meal planning, Sausage is running on a core promise to simplify dinner decisions.
Judge Rules Green Party Candidate Accused of Being GOP Plant Can Be Kicked Off Ballot in PA-07
A Commonwealth Court judge ruled Friday afternoon that Andrew Tupone, a hopeful Green Party candidate in the 7th Congressional District, can be removed from the ballot despite collecting sufficient signatures to appear on it. Tupone, however, said he plans to appeal. “The establishment parties are fighting to keep me off…
Kamin Science Center and Science of Speed shut down for four-day refresh in Pittsburgh
Planning a trip to the Kamin Science Center this week? The museum will be closed through Friday for exhibit maintenance and updates.
Kenya moves to regularize foreign businesses after president's remarks alarm immigrant communities
The Kenyan government on Tuesday gave foreigners running businesses in the country 90 days to obtain or update required documents, including work permits and business licenses. The move followed rema...
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Mackenzie, Bresnahan, McCormick To Speak at "Trumpapalooza" in Dallas
Pennsylvania will be well represented at the podium as the Republican Party holds a midterm national convention in Dallas on Wednesday and Thursday. A pair of GOP congressmen - Reps. Ryan Mackenzie (R-07) and Rob Bresnahan (R-08) - and Sen. Dave McCormick will be among the 109 officials, candidates and…
New Hampshire voters pick midterm nominees as Sen. Shaheen's exit sparks scramble for key seats
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Florida IAM Members Focus on Political Mobilization at Fall Conference
The IAM's Florida State Council recently held its fall conference, bringing together union leaders and delegates to focus on political education, voter mobilization, and strengthening the voice of working families across the state. Led by President Mike Phillips, the conference emphasized the importance of supporting pro-labor candidates and increasing member participation in the political process.
Texas Sunset Review offers chance to address the mental health crisis-to-prison pipeline
Updates in policy for people with developmental disabilities and serious mental illness could reduce repeated cycling through the carceral system, advocates say
National GOP to feature Cunningham vs. Vasquez race at midterm convention
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Steve Flowers: Political reassurances and revelations in 2026
Faces and places and races change in politics, but one thing that stays the same is the candidate who has the most money for campaign advertising and vote gathering, nine times out of ten wins.
IPC Systems' Emissions Reduction Targets Validated by the Science Based Targets Initiative
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Does Klay Thompson Move Impact Mavs' Updated NBA Power Rankings?
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Want a solution to plastic pollution? Scientists urge UN to require global reporting
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Daniel Farke provides fitness update ahead of Chelsea clash
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List of DVD release dates for Sept. 8 and beyond
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They're accusing opponents of being in the pockets of drugmakers or health insurers.
‘Pawn Stars’ star Rick Harrison gets major health update after emergency heart surgery
It comes just days after he was rushed into surgery.
‘Pawn Stars’ star Rick Harrison gets major health update after emergency heart surgery
It comes just days after he was rushed into surgery.
What to Watch in Tuesday’s New Hampshire Primary Elections
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Former Knox County Trustee Justin Biggs' friends left office with him
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This House candidate wants you to know she helped imprison a fellow Democrat
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Atelier Karia: The Night Kingdom & the Guide of Memories launches on February 25, 2027
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Samsung monthly updates: September 2026 security patch gets detailed
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GenSight Biologics Provides September 2026 Business Updates
PARIS, September 08, 2026--Regulatory News: GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today provided business updates covering the summer of 2026 and confirmed the publication date for the Company’s financial statement covering the first half of 2026.
What’s Next for the MCU? Every Upcoming Phase 6 Movie and TV Show Release Date
With Phase Six of the Marvel Cinematic Universe set to wrap up in 2028 with Avengers: Secret Wars, fans are already looking to what lies beyond the horizon. Marvel Studios ...
Candidates offering healthcare slogans, not solutions: Dr. Ashish Jha
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New Hampshire voters pick nominees as Sen. Shaheen’s exit sparks a scramble for key seats
New Hampshire primary voters are choosing candidates for Congress, governor and the state Legislature, with the retirement of U.S. Sen. Jeanne Shaheen creating the most competitive races | K-DAWN
New Hampshire voters pick nominees as Sen. Shaheen’s exit sparks a scramble for key seats
New Hampshire primary voters are choosing candidates for Congress, governor and the state Legislature, with the retirement of U.S. Sen. Jeanne Shaheen creating the most competitive races | Talk Radio 1210 WPHT
New Hampshire voters pick nominees as Sen. Shaheen’s exit sparks a scramble for key seats
New Hampshire primary voters are choosing candidates for Congress, governor and the state Legislature, with the retirement of U.S. Sen. Jeanne Shaheen creating the most competitive races | WWL
Senate candidate Todd Achilles talks costs, health care at Twin Falls County Fair
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Phillies Handed Major Injury Update on Impact Left-Handed Pitcher
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Acton attack suspect not registered with political party, voted in 2016 GOP primary
Amy Acton was eating a sandwich, taking pictures and talking with people at the Canfield Fair when Tra Eley says she stopped at his food truck Sunday.For roughl
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With Ohio’s governorship up for grabs, a toxic race turns violent
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Politics on parade: Candidates join Buena Vista Labor Day celebration
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