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BGI Genomics Launches "Digital Life Twin" Framework to Power Proactive Health

Commemorating BGI Group's 27th anniversary, BGI Genomics today introduced its Digital Life Twin framework alongside an advanced multi-omics diagnostic portfolio at the 2026 Global New Product Launch Event. Grounded in over two decades of population-scale genetic discoveries, the launch marks a decisive transition from traditional, reactive diagnostics to continuous, predictive health management across the entire human lifecycle.

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Sep 9 • 9:45 AM EDT • Health • finance.yahoo.com
Barcelona vs Feyenoord, Champions League: TV & Streaming, Live Thread

Join us for the first Barcelona European adventure of the season!

sports.yahoo.com logo
Sep 9 • 9:45 AM EDT • Sports • sports.yahoo.com
Luma locks down 15-year, $410M fund for life science investments

Luma Group today announced the final close of its inaugural life sciences venture capital fund, totaling $410 million. The New York-based investment firm has had a grip on life sciences since its founding in 2023. The funds unveiled today, dubbed LumaBio Fund I, include investments that have already been made into more than 10 biotechs. They include the likes of eye disease-focused Character Biosciences, rebranded Belgian biotech Coultreon Biopharma and cellular rejuvenation company Altos Labs. The fund saw early success when one of the companies it co-founded, called Vaccine Company, was picked up by Eli Lilly earlier this year for up to $1.55 billion. The acquisition of the in vivo nanoparticle technology-focused biotech formed part of a trio of vaccine buys for the Big Pharma, which has itself been on a prolonged spending spree in 2026. Luma's fund is structured as a 15-year investment with plans to support groundbreaking science and support companies through key milestones from discovery to commercialization, Luma explained in the release. "We founded Luma Group on the belief that extraordinary science, supported by patient, long-term capital, has the power to improve millions of lives," Joshua Fink, founder and managing member of Luma Group, said in the release. "This fund represents more than capital—it is a commitment to partnering with extraordinary innovators as they translate visionary science into life-changing medicines."

fiercebiotech.com logo
Sep 9 • 9:43 AM EDT • Science • fiercebiotech.com
Heyde Center entertainment

Todd Oliver and Irving The Talking Dog will be on stage at the Heyde Center For The Arts Sunday, Sept. 13, at 2 p.m. A nationally-recognized Ventriloquist and comedian, Oliver

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Sep 9 • 9:38 AM EDT • Entertainment • news-shield.com
NCMC expands mental health support with 988 Awareness Day events and weekly talks
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Sep 9 • 9:29 AM EDT • Health • upnorthlive.com
Zwift announces updated Ride V2 indoor smart bike, plus new in-game roads, bikes, events and cross-platform integrations

Everything coming this season on Zwift

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Sep 9 • 9:00 AM EDT • Technology • bikeradar.com
The Cost of Cutting American Science: How Federal Cuts Diminish Public Health Capacity

Among the federal government’s many responsibilities is the work it does to protect public health. Federal agencies monitor our food supply to ensure safety, conduct research to better understand emerging health threats, provide funding for public health programs in communities and work to detect and respond to disease outbreaks. Americans rely on these efforts every day—in a 2024 online survey, 74% of respondents said that “if the federal government issued safety guidance about food you eat regularly,” they would follow it. Changes to Federal Public Health Capacity The Trump administration’s efforts to reshape the federal government have resulted in significant impacts on our nation’s public health capacity over the past 20 months, affecting the response to health concerns such as measles, Ebola and cyclosporiasis. Agencies with core public health, food safety and disease prevention responsibilities experienced large workforce decreases during the first year of the administration. At the Centers for Disease Control and Prevention, for instance, the workforce in February 2026 was 26.7% smaller than in September 2024 before the start of the Trump administration. The Food and Drug Administration saw a similarly steep decline of 21.6%. Agencies such as the National Institutes of Health, Substance Abuse and Mental Health Services Administration and Food Safety and Inspection Service also experienced large workforce decreases. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); Changes can also be seen in crucial public health occupations. The number of federal food inspectors, for example, decreased by more than half between September 2024 and February 2026, going from 1,035 to 473. This is the lowest number of food inspectors employed by the federal government since at least 2005. By February 2026, there were also 33.3% fewer federal public health program specialists, whose work includes advising federal funding recipients on public health activities and analyzing the effectiveness of public health programs. Government’s capacity is diminished as employees with specialized knowledge and experience in protecting the public and responding to health risks depart, leaving agencies less prepared to carry out their public health missions. There also have been vacancies in critical high-level leadership positions at public health agencies, most notably at the CDC, which had a permanent Senate-confirmed director for less than a month between January 2025 and early August 2026. Although the CDC has previously been led by acting directors at the start of an administration, the nearly yearlong gap since the departure of the administration’s first permanent director in August 2025 is without precedent. As of August 2026, the FDA is also currently without a Senate-confirmed commissioner following the previous commissioner’s resignation in May 2026. Additionally, public health agencies are experiencing increased politicization of their leadership ranks. In agencies such as the CDC and Food Safety and Inspection Service, the number of individuals in the Senior Executive Service—the most senior career leaders in government—has declined significantly, while at the same time the number of political appointees has reached record levels. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); At the CDC, for example, the number of career SES decreased 42.9% between December 2024 and February 2026, while the number of non-Senate confirmed political appointees at the agency was six times larger than the agency’s historical average from 2009 and 2024. Knowledgeable career leaders are integral to the ability of public health agencies to carry out their work with scientific integrity and professional judgment, and rapid leadership turnover and increased politicization threaten agencies’ ability to make evidence-based decisions to protect our health. The upheaval and politicization in public health agencies have also negatively affected employee engagement. Strong employee engagement is crucial to the ability of agencies to carry out their mission and successfully provide essential services to the public. In the 2025 Public Service Viewpoint Survey conducted by the Partnership for Public Service, the Department of Health and Human Services—which encompasses major public health agencies such as the CDC and FDA—had an employee engagement and satisfaction score of 20.4 out of 100, one of the lowest among large agencies. Only 2.8% of HHS employees indicated trust in their political leaders and only 8.7% reported confidence that they could report a suspected violation of law or regulation without retaliation. Employees at HHS also reported that the agency’s ability to provide services to the public had suffered. Nearly half of employees at HHS, 47.5%, said their work unit was worse at delivering quality services compared to its performance in 2024. In addition, 57.8% said their work unit was performing worse at fulfilling stakeholder needs. In addition to the work done within federal agencies, the federal government also distributes significant funding for public health and disease prevention work to state and local governments, nonprofits and small businesses—funding which has been significantly disrupted. At the CDC, for example, there was a 71.9% decrease in the amount of project grant funding issued in fiscal year 2025 compared to fiscal year 2024. The FDA also issued far less funding in fiscal year 2025—a 21.3% decrease from its fiscal year 2024 funding. Changes in federal funding include the ending of grants to community organizations that worked on HIV prevention and the cancellation of funding for research into improvements to patient safety and healthcare quality. These changes go beyond federal agencies to impact the broader public health ecosystem, including the state and local health departments responsible for much of the on-the-ground public health work in their communities. About 80% of the CDC’s domestic funding is directed towards state and local partners—meaning that cuts to CDC funding can ultimately result in cuts to state and local public health capacity. Federal agencies also provide expertise and assistance to state and local health agencies as they deal with particular health challenges, but workforce cuts have resulted in fewer federal employees available to help. The Impact of Changes to Public Health Capacity These changes to federal public health capacity are not abstract concerns. Disrupted programs, reduced funding and lost expertise at public health agencies across all levels of government threaten the public’s physical well-being and safety. In some cases, this has already led to harm. The most immediate impacts of federal cuts were seen in interruptions to ongoing public health programs and crisis responses. In one instance, when CDC grants were canceled during the 2025 Texas measles outbreak—the most severe measles outbreak in 25 years—public health officials in Lubbock, Texas were forced to pause parts of their measles response work supported by the frozen funding. Lubbock’s director of public health further said that a lack of available CDC experts to reach out to for advice “definitely” impacted the department’s response to the measles crisis. Cuts to federal funding also forced Dallas County Health and Human Services to cut staff and cancel 50 community vaccination clinics during the outbreak. Public health work outside of major outbreak responses was also disrupted. For example, in April 2025, the Milwaukee Public Health Department was unexpectedly unable to reach experts on lead poisoning due to firings at the CDC when responding to concerns about lead contamination in Milwaukee public schools. Due to federal workforce cuts, several programs at the CDC, including Alzheimer’s and epilepsy programs, have also become trapped in limbo—existing on paper, but without the staff necessary to operate. More recent crises reveal how federal cuts have weakened the public health infrastructure needed to prevent and respond to dangerous new outbreaks. Internationally, cuts at the U.S. Agency for International Development eliminated funding for disease testing and contact tracing abroad, which delayed detection of and responses to the 2026 Ebola outbreak in the Democratic Republic of Congo. While international outbreaks may seem far removed, the unchecked spread of disease in any country can quickly pose a danger to economic well-being, security and health around the world. Within the United States, public health cuts inhibited responses to the summer 2026 outbreak of the food-borne parasite cyclospora. At the federal level, cuts to funding for lab equipment and for CDC staff with expertise in parasitic infections—including 9 out of 11 staff members at the lab responsible for identifying parasitic outbreaks in 2025— contributed to the largest reporting delay in outbreak cases at the CDC in 15 years. Conflicting communications from the FDA about the source of the outbreak, which followed cuts to the agency’s communications department, additionally led to confusion among the public about how to best avoid infection. At the same time, cuts to HHS funding and support for local and state public health slowed some health departments’ responses to the crisis. The exact costs of these delays, constraints and confusion in public health responses are difficult to estimate. However, their message is clear: federal cuts have already made containing threats to public health even more of a challenge. Conclusion Protecting public health—from food safety to disease prevention—is one of the federal government’s most important missions. Dramatic and haphazard cuts to federal agencies and funding have already disrupted the public health system, impacting the response to challenges such as measles, lead poisoning and cyclosporiasis. The U.S. public health system needed improvement before these disruptions. Since 2022, federal leadership and coordination in response to public health outbreaks has been on the Government Accountability Office’s High-Risk List of areas in need of attention to improve government effectiveness and efficiency. Recent cuts only compound these concerns. The chaotic dismantling of government and resulting disruptions to crucial functions like public health and disease prevention highlight the need for meaningful reform and concrete policy proposals to reimagine how government can better serve the public and be more effective, responsive and accountable. To learn more about the impact of federal cuts to public health and science more broadly, visit The Cost of Cutting American Science. Learn more For more information on the Partnership for Public Service’s government reform initiative, visit Government for a New Era. View here In line with The Cost of Cutting American Science, federal workforce data in this brief is as of February 2026

ourpublicservice.org logo
Sep 9 • 9:00 AM EDT • Science • ourpublicservice.org
The Cost of Cutting American Science: How Federal Cuts Diminish Public Health Capacity

Among the federal government’s many responsibilities is the work it does to protect public health. Federal agencies monitor our food supply to ensure safety, conduct research to better understand emerging health threats, provide funding for public health programs in communities and work to detect and respond to disease outbreaks. Americans rely on these efforts every day—in a 2024 online survey, 74% of respondents said that “if the federal government issued safety guidance about food you eat regularly,” they would follow it. Changes to Federal Public Health Capacity The Trump administration’s efforts to reshape the federal government have resulted in significant impacts on our nation’s public health capacity over the past 20 months, affecting the response to health concerns such as measles, Ebola and cyclosporiasis. Agencies with core public health, food safety and disease prevention responsibilities experienced large workforce decreases during the first year of the administration. At the Centers for Disease Control and Prevention, for instance, the workforce in February 2026 was 26.7% smaller than in September 2024 before the start of the Trump administration. The Food and Drug Administration saw a similarly steep decline of 21.6%. Agencies such as the National Institutes of Health, Substance Abuse and Mental Health Services Administration and Food Safety and Inspection Service also experienced large workforce decreases. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); Changes can also be seen in crucial public health occupations. The number of federal food inspectors, for example, decreased by more than half between September 2024 and February 2026, going from 1,035 to 473. This is the lowest number of food inspectors employed by the federal government since at least 2005. By February 2026, there were also 33.3% fewer federal public health program specialists, whose work includes advising federal funding recipients on public health activities and analyzing the effectiveness of public health programs. Government’s capacity is diminished as employees with specialized knowledge and experience in protecting the public and responding to health risks depart, leaving agencies less prepared to carry out their public health missions. There also have been vacancies in critical high-level leadership positions at public health agencies, most notably at the CDC, which had a permanent Senate-confirmed director for less than a month between January 2025 and early August 2026. Although the CDC has previously been led by acting directors at the start of an administration, the nearly yearlong gap since the departure of the administration’s first permanent director in August 2025 is without precedent. As of August 2026, the FDA is also currently without a Senate-confirmed commissioner following the previous commissioner’s resignation in May 2026. Additionally, public health agencies are experiencing increased politicization of their leadership ranks. In agencies such as the CDC and Food Safety and Inspection Service, the number of individuals in the Senior Executive Service—the most senior career leaders in government—has declined significantly, while at the same time the number of political appointees has reached record levels. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); At the CDC, for example, the number of career SES decreased 42.9% between December 2024 and February 2026, while the number of non-Senate confirmed political appointees at the agency was six times larger than the agency’s historical average from 2009 and 2024. Knowledgeable career leaders are integral to the ability of public health agencies to carry out their work with scientific integrity and professional judgment, and rapid leadership turnover and increased politicization threaten agencies’ ability to make evidence-based decisions to protect our health. The upheaval and politicization in public health agencies have also negatively affected employee engagement. Strong employee engagement is crucial to the ability of agencies to carry out their mission and successfully provide essential services to the public. In the 2025 Public Service Viewpoint Survey conducted by the Partnership for Public Service, the Department of Health and Human Services—which encompasses major public health agencies such as the CDC and FDA—had an employee engagement and satisfaction score of 20.4 out of 100, one of the lowest among large agencies. Only 2.8% of HHS employees indicated trust in their political leaders and only 8.7% reported confidence that they could report a suspected violation of law or regulation without retaliation. Employees at HHS also reported that the agency’s ability to provide services to the public had suffered. Nearly half of employees at HHS, 47.5%, said their work unit was worse at delivering quality services compared to its performance in 2024. In addition, 57.8% said their work unit was performing worse at fulfilling stakeholder needs. In addition to the work done within federal agencies, the federal government also distributes significant funding for public health and disease prevention work to state and local governments, nonprofits and small businesses—funding which has been significantly disrupted. At the CDC, for example, there was a 71.9% decrease in the amount of project grant funding issued in fiscal year 2025 compared to fiscal year 2024. The FDA also issued far less funding in fiscal year 2025—a 21.3% decrease from its fiscal year 2024 funding. Changes in federal funding include the ending of grants to community organizations that worked on HIV prevention and the cancellation of funding for research into improvements to patient safety and healthcare quality. These changes go beyond federal agencies to impact the broader public health ecosystem, including the state and local health departments responsible for much of the on-the-ground public health work in their communities. About 80% of the CDC’s domestic funding is directed towards state and local partners—meaning that cuts to CDC funding can ultimately result in cuts to state and local public health capacity. Federal agencies also provide expertise and assistance to state and local health agencies as they deal with particular health challenges, but workforce cuts have resulted in fewer federal employees available to help. The Impact of Changes to Public Health Capacity These changes to federal public health capacity are not abstract concerns. Disrupted programs, reduced funding and lost expertise at public health agencies across all levels of government threaten the public’s physical well-being and safety. In some cases, this has already led to harm. The most immediate impacts of federal cuts were seen in interruptions to ongoing public health programs and crisis responses. In one instance, when CDC grants were canceled during the 2025 Texas measles outbreak—the most severe measles outbreak in 25 years—public health officials in Lubbock, Texas were forced to pause parts of their measles response work supported by the frozen funding. Lubbock’s director of public health further said that a lack of available CDC experts to reach out to for advice “definitely” impacted the department’s response to the measles crisis. Cuts to federal funding also forced Dallas County Health and Human Services to cut staff and cancel 50 community vaccination clinics during the outbreak. Public health work outside of major outbreak responses was also disrupted. For example, in April 2025, the Milwaukee Public Health Department was unexpectedly unable to reach experts on lead poisoning due to firings at the CDC when responding to concerns about lead contamination in Milwaukee public schools. Due to federal workforce cuts, several programs at the CDC, including Alzheimer’s and epilepsy programs, have also become trapped in limbo—existing on paper, but without the staff necessary to operate. More recent crises reveal how federal cuts have weakened the public health infrastructure needed to prevent and respond to dangerous new outbreaks. Internationally, cuts at the U.S. Agency for International Development eliminated funding for disease testing and contact tracing abroad, which delayed detection of and responses to the 2026 Ebola outbreak in the Democratic Republic of Congo. While international outbreaks may seem far removed, the unchecked spread of disease in any country can quickly pose a danger to economic well-being, security and health around the world. Within the United States, public health cuts inhibited responses to the summer 2026 outbreak of the food-borne parasite cyclospora. At the federal level, cuts to funding for lab equipment and for CDC staff with expertise in parasitic infections—including 9 out of 11 staff members at the lab responsible for identifying parasitic outbreaks in 2025— contributed to the largest reporting delay in outbreak cases at the CDC in 15 years. Conflicting communications from the FDA about the source of the outbreak, which followed cuts to the agency’s communications department, additionally led to confusion among the public about how to best avoid infection. At the same time, cuts to HHS funding and support for local and state public health slowed some health departments’ responses to the crisis. The exact costs of these delays, constraints and confusion in public health responses are difficult to estimate. However, their message is clear: federal cuts have already made containing threats to public health even more of a challenge. Conclusion Protecting public health—from food safety to disease prevention—is one of the federal government’s most important missions. Dramatic and haphazard cuts to federal agencies and funding have already disrupted the public health system, impacting the response to challenges such as measles, lead poisoning and cyclosporiasis. The U.S. public health system needed improvement before these disruptions. Since 2022, federal leadership and coordination in response to public health outbreaks has been on the Government Accountability Office’s High-Risk List of areas in need of attention to improve government effectiveness and efficiency. Recent cuts only compound these concerns. The chaotic dismantling of government and resulting disruptions to crucial functions like public health and disease prevention highlight the need for meaningful reform and concrete policy proposals to reimagine how government can better serve the public and be more effective, responsive and accountable. To learn more about the impact of federal cuts to public health and science more broadly, visit The Cost of Cutting American Science. Learn more For more information on the Partnership for Public Service’s government reform initiative, visit Government for a New Era. View here In line with The Cost of Cutting American Science, federal workforce data in this brief is as of February 2026

ourpublicservice.org logo
Sep 9 • 9:00 AM EDT • Health • ourpublicservice.org
Has Seattle become a bona fide EDM town?

As indie-centric summer festivals have faded in recent years, big-tent dance music events have flourished, fueling an EDM renaissance in a city that prides itself on its grungier legacy.

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Sep 9 • 9:00 AM EDT • Entertainment • yakimaherald.com
Southern Maryland nonprofit fills financial gaps for mental health resources

Over the last 25 years, Jennifer Voorhaar of Charlotte Hall has seen how financial barriers can prevent people from prioritizing their mental health.

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Sep 9 • 8:45 AM EDT • Health • somdnews.com
Rory McIlroy Headlines Star-Studded 2026 Irish Open at Doonbeg

Rory McIlroy defends his Irish Open title at Doonbeg against Jon Rahm, Shane Lowry, Brooks Koepka and one of the event’s strongest recent fields.

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Sep 9 • 8:00 AM EDT • Sports • sports.yahoo.com
GameSquare Enters Definitive Contribution Agreement to Acquire Sports, Music and Entertainment IP Assets from FanEngine

("FanEngine"), a technology and media asset consolidator that collectively enables sports, music and entertainment IP owners to build direct relationships with fans and monetize those relationships through gamification, brand integration, events, content, commerce, and experiences.The Transaction is expected to be immediately accretive to profitability and represents the next step in GameSquare's strategy to build a differentiated, end-to-end platform spanning audience analytics, creators, agenc

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Sep 9 • 8:00 AM EDT • Entertainment • finance.yahoo.com
Collins not heading to Dallas GOP convention

While speaking to reporters in Brewer on Tuesday, Collins said many of the Republicans facing tough races will not be in attendance.

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Sep 9 • 7:56 AM EDT • Politics • spectrumlocalnews.com
Wheeling pet care business halts van service after dog’s death

Waggles Pet Resort intends to “evaluate steps to help prevent a tragedy like this from ever happening again,” the company announced in a prepared statement.

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Sep 9 • 7:53 AM EDT • Business • chicagotribune.com
Dortmund football celebrates a duo that celebrates itself too

After Santiago Mourino’s equalizer for 1-1 (67'), the hoped-for home win against last season’s third-placed team from Spain briefly hung in the balance. Goalkeeper Gregor Kobel even prevented a po...

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Sep 9 • 7:41 AM EDT • Sports • sports.yahoo.com
iPhone 18 Pro Details Purportedly Leaked By Verizon's AI Assistant

A series of screenshots shared with MacRumors today seemingly show Verizon's AI chat assistant answering detailed questions about the iPhone 18 Pro and iPhone 18 Pro Max, just hours before Apple's announcement event. The screenshots were shared privately with MacRumors by X user "mehrtosh," who says the responses came from the "Ask Verizon" AI assistant built into the carrier's app.

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Sep 9 • 7:28 AM EDT • Technology • macrumors.com
Singapore’s Prime Minister Gets a Big Raise

Singapore’s prime minister, Lawrence Wong, got the bump as part of a longstanding policy to pay high salaries to public servants in order to attract top talent and prevent corruption.

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Sep 9 • 6:42 AM EDT • Politics • nytimes.com
Apple’s (AAPL) “Surprise and Shine” Event Tests Its Foldable iPhone Against Huawei and Xiaomi

Wall Street sees Apple Inc. (NASDAQ:AAPL) entering a significant hardware cycle ahead of its “Surprise and Shine” event streaming live on Wednesday, September 9, 2026. Bank of America, in particular, expects a broad slate of new Apple devices led by new iPhones and a Foldable iPhone. On September 8, BofA Securities analyst Wamsi Mohan reiterated a […]

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Sep 9 • 6:15 AM EDT • Technology • finance.yahoo.com
Peter Stanbury on the business case for sustainablity in drinks

As we count down to next month’s Sustainability in Drinks event in London (October 21), Dr Peter Stanbury, research director of the influential Sustainable Wine Roundtable , makes the case for why all drinks companies should be taking not just taking sustainability seriously but how increasingly it is being seen by banks and insurance houses as a vital part of running an effective and competent business and a prerequisite for their continued support.

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Sep 9 • 6:10 AM EDT • Business • the-buyer.net
Donald Trump Jr.'s venture capital firm rejects House Democrat's accusations of "insider political influence"

Rep. Jamie Raskin launched an investigation last month into the president's son's investment firm and its "almost clairvoyant" business moves.

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Sep 9 • 6:05 AM EDT • Politics • cbsnews.com
High-Signal Publisher
5 fun events happening in Madison this week, Sept. 10-16 🎤🧶🍺

This week around Madison, see SNL's Kam Patterson, check out the Great Wisconsin Quilt Show, celebrate Oktoberfest at Working Draft and more.

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Sep 9 • 6:05 AM EDT • Entertainment • captimes.com
Republicans tie midterm hopes to Trump at Dallas convention despite political risks

Many Republicans in competitive House and Senate races are skipping the convention.

reuters.com logo
Sep 9 • 6:03 AM EDT • Politics • reuters.com
Apple expected to unveil first folding phone, with new CEO Ternus in command

Apple is widely ‌expected to unveil a pricey folding iPhone at a launch event on Wednesday at its Cupertino, California, headquarters.

reuters.com logo
Sep 9 • 6:02 AM EDT • Technology • reuters.com
GOP's first midterm convention kicks off Wednesday, putting Dallas at center of national politics

The Republican Party's first-ever midterm convention begins in Dallas as Trump and GOP leaders rally voters, while Democrats prepare their own counterprogramming ahead of November.

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Sep 9 • 6:01 AM EDT • Politics • keranews.org
California voters can fix a flaw in the state's recall system

Proposition 5 on the November ballot would prevent a governor's replacement from taking office by winning just marginal support. It's the first step toward a badly needed overhaul.

latimes.com logo
Sep 9 • 6:00 AM EDT • Politics • latimes.com
Calendar of events

Ongoing

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Sep 9 • 5:45 AM EDT • Entertainment • valleybreeze.com
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Spalletti target immediate return for two Juventus stars

With injuries ravaging his midfield, Luciano Spalletti is set to be forced into recalling players who had been expected to spend more time building their fitness before becoming heavily involved in fi...

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Sep 9 • 5:35 AM EDT • Sports • sports.yahoo.com
Will Trump’s Midterm Convention Help or Hurt Republicans? 5 Things to Watch.

At an unusual gathering in Dallas, some of the party’s top candidates will be forced to decide just how tightly to tether themselves to an unpopular president.

nytimes.com logo
Sep 9 • 5:06 AM EDT • Politics • nytimes.com
These are the best things to do in Brevard this weekend, Sept. 11-17

Find your weekend adventure! Zoo days, live music and theater auditions top our list of Brevard's best things to do.

floridatoday.com logo
Sep 9 • 5:00 AM EDT • Entertainment • floridatoday.com
The Republicans staying away from the ‘Trump-a-palooza’ convention

(CNN) — Republicans will gather in Dallas this week for a midterm convention that’s a version of the type normally held in presidential election years.

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Sep 9 • 5:00 AM EDT • Politics • kten.com
After a decade as GOP’s main character, Trump gets one more starring role at midterm convention

For a decade, President Donald Trump has made himself his party’s main character — a singular force around whom its rallies, conventions and political identity have revolved.

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Sep 9 • 5:00 AM EDT • Politics • cnn.com
8 events in Lancaster County this weekend, from a whoopie pie festival to an herb fest

There's a lively weekend on tap for Lancaster County.

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Sep 9 • 5:00 AM EDT • Entertainment • lancasteronline.com
New outpatient clinic focused on suicide prevention opens in Burlington

University of Vermont Health held an open house last week to celebrate the opening of the Asha Clinic, which it describes as the only program in the region focused exclusively on suicide care. The clinic's work is led by Craig Bryan, an expert in suicide treatment and research.

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Sep 9 • 5:00 AM EDT • Health • vermontpublic.org
Republicans kick off a 'Trumpapalooza' of a midterm convention Wednesday in Texas

Republicans have never held a midterm convention before. But there's also never been a president like Donald Trump. Billed as a "Trumpapalooza," the unprecedented event kicks of in Dallas Wednesday.

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Sep 9 • 5:00 AM EDT • Politics • npr.org
High-Signal Publisher
Texas, Florida housing markets lead the Sun Belt real estate rebound

Home prices and inventory are starting to stabilize in parts of Texas and Florida, raising hopes that the Sun Belt housing bust is nearing a bottom.

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Sep 9 • 4:24 AM EDT • Business • businessinsider.com
Today’s Papers – Big Inter gifts, Juventus in trouble

La Gazzetta dello SportJuve, you need to get yourself blessed.Locatelli returns in 2027; stop for BogaAfter Yildiz and Thuram, the captain underwent surgery too (could be out for six months)Inter’s ...

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Sep 9 • 3:55 AM EDT • Sports • sports.yahoo.com
Slime Molds and a double Ig Nobel Prize winner and a big, great science adventure

” ‘This is dangerous’: slime moulds and the bitter debate over the nature of intelligence — Scientists are battling over whether supposedly simple organisms should be considered ‘intelligent’…

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Sep 9 • 3:24 AM EDT • Science • improbable.com
Healthwatch: Should kids have mental health days?

Every school year, children eventually need to take a sick day – but what about a mental health day?

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Sep 9 • 3:24 AM EDT • Health • wsls.com
Google warns of new Chrome zero-day bug exploited in attacks

Google has patched 230 vulnerabilities on Tuesday, including another actively exploited Chrome zero-day bug, the seventh such vulnerability patched since the start of the year.

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Sep 9 • 2:25 AM EDT • Technology • bleepingcomputer.com
La Porte County Business Expo Brings Local Business Together September 17

Michigan City, IN – Businesses and community members from throughout La Porte County are invited to connect, discover local products and services, and build new contacts at the La Porte County Business Expo on Thursday, September 17, from 4:30 to 6:30 p.m. at Purdue Northwest – Westville campus. The collaborative event is hosted by the Michigan City Chamber, Westville Area Chamber, and La Porte Economic Advancement Partnership (LEAP) and will showcase businesses from across La Porte County and beyond. Attendees will have the opportunity to meet the people behind local businesses, learn about the products and services available and make

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Sep 9 • 1:25 AM EDT • Business • wimsradio.com
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Amazon Cargo Jet Pilots Appeared to Try Aborting Landing, N.T.S.B. Investigation Indicates

The sequence of events detailed by National Transportation Safety Board investigators showed that the pilots lost crucial seconds before the plane ran off the runway in Miami.

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Sep 9 • 12:44 AM EDT • Politics • nytimes.com
Apple to unveil latest iPhone lineup

Apple is unveiling its latest generation of iPhones on Wednesday at an event headlined by new CEO John Ternus, who took over from Tim Cook on Sept. 1.

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Sep 9 • 12:03 AM EDT • Technology • apnews.com
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Brendan Schaub Trashes UFC 332 Main Event

Former UFC heavyweight fighter Brendan Schaub trashed the upcoming UFC 332 main event between Natalia Silva and Wang Cong.With Valentina Shevchenko out for one year due to injury, she was forced to vacate the UFC women’s flyweight title, so Silva and Wang will now fight for the undisputed strap in the UFC 332 headliner.It’s a […] The post Brendan Schaub Trashes UFC 332 Main Event appeared first on HEAVY.

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Sep 8 • 11:50 PM EDT • Sports • sports.yahoo.com
Jessica Pegula rallies back into U.S. Open semifinals

BUFFALO, N.Y. (WIVB) — Jessica Pegula came back to win her U.S. Open quarterfinal match Tuesday night at Arthur Ashe Stadium, reaching the semifinals of the Grand Slam event for the third year in a row. Pegula, the 32-year-old Buffalonian ranked No. 3 in the world, defeated No. 26 seed Emma Navarro in the all-American […]

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Sep 8 • 11:10 PM EDT • Sports • sports.yahoo.com
Allegheny County Council proposes bill that could regulate AI use in political campaign materials

Members of Allegheny County Council on Tuesday introduced a bill that would require political candidates to disclose their use of artificial intelligence in campaign materials, an effort aimed at preventing voters from being misled by AI-generative content. If passed, the ordinance would establish disclosure requirements for AI-generated campaign content used

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Sep 8 • 11:07 PM EDT • Politics • triblive.com
Detmers dominates deficient Red Sox in 6-1 Angels win

Tomorrow marks the end of a stretch in which the Red Sox play 54 games in 56 days (dating back to July 17th), and I’m kind of thrilled about that because I’m extremely over these half baked games. Tonight in particular was just a bad combination of events. Reid Detmers, who has been outstanding since […]

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Sep 8 • 10:55 PM EDT • Sports • sports.yahoo.com
Can the 'best showman in politics' deliver again? GOP bets on Trump at historic midterm convention

Donald Trump headlines the first-ever GOP midterm convention in Dallas, aiming to energize low-propensity MAGA voters ahead of key 2026 races.

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Sep 8 • 10:43 PM EDT • Politics • foxnews.com
Republicans hold first-ever midterm convention in Dallas

Republicans are making political history this week with the first-ever midterm convention.

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Sep 8 • 10:43 PM EDT • Politics • winknews.com
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LSU finalizes roster, preventing the addition of two former NFL players
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Sep 8 • 10:21 PM EDT • Sports • sports.yahoo.com
Health-oriented Korean rice bowl restaurant opens on Whitney Avenue

BIBIM, a new venture from the owner of bb.q Chicken, aims to offer affordable, healthy Korean fare in a customizable form. In its opening week, the restaurant has sold 1,000 bowls, according to a manager.

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Sep 8 • 10:11 PM EDT • Health • yaledailynews.com
New Apple CEO to face first test with foldable iPhone launch

Apple is expected to unveil a slew of new and updated devices, including a long-rumored foldable iPhone, when it holds its annual late-summer hardware event on Wednesday in Cupertino, California.The tech giant is expected to finally reveal a long-awaited foldable iPhone, currently rumored to be called the iPhone Ultra, which will start at $2,000, according to reports.

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Sep 8 • 9:20 PM EDT • Technology • uk.finance.yahoo.com
Man accused of assault, inducing panic at Dr. Amy Acton event pleads not guilty

The armed Ohio man investigators said set off a security scare involving Democratic gubernatorial candidate Dr. Amy Acton pleaded not guilty in court Tuesday.

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Sep 8 • 9:13 PM EDT • Politics • news5cleveland.com
Revival of Hope returns to Winterville with national speakers, mental health workshops

The free, two-day community event will run Friday, Sept. 18, and Saturday, Sept. 19, under a large tent on East Fire Tower Road in Winterville.

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Sep 8 • 9:02 PM EDT • Health • witn.com
Halo composer Marty O’Donnell takes Nevada race to RNC stage

Nevada congressional candidate and “Halo” composer Marty O’Donnell will speak at the RNC’s Dallas midterm convention as he challenges Rep. Susie Lee.

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Sep 8 • 8:18 PM EDT • Politics • reviewjournal.com
What to watch as Republicans gather in Dallas for Trump's unusual midterm convention

Midterms are often difficult for the party in power in Washington, and Trump believes the event can juice enthusiasm for the party and boost turnout among his voters.

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Sep 8 • 7:49 PM EDT • Politics • pbs.org
Apple adds 37 hardware identifiers ahead of ‘Surprise and Shine’ event

Apple has added new hardware identifiers for iPhones, iPads, Macs, and other devices, some of which could be announced as soon as tomorrow.

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Sep 8 • 7:27 PM EDT • Technology • 9to5mac.com
Missouri's redistricting fight in turmoil as U.S. Supreme Court and federal rulings clash

U.S. District Judge Stephen Clark last-minute order temporarily prevents Secretary of State Denny Hoskins from using any map other than the one passed in 2025 – a move that will almost certainly be appealed.

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Sep 8 • 7:26 PM EDT • Politics • stlpr.org
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All North Carolina student IDs will have mental health resources printed on them as part of the Student Helpline Act

RALEIGH, N.C. (WNCN) — Today is 988 Day, a nationwide event dedicated to promoting mental health support and suicide prevention through the 988 Suicide & Crisis Lifeline, and now, in North Caro…

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Sep 8 • 7:11 PM EDT • Health • cbs17.com
Apple wanted the iPhone Ultra to cost $1,999, new report says

But the RAM apocalypse intervened. Apple is holding its big annual iPhone launch event on September 9, and it's widely expected to unveil the iPhone Ultra...

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Sep 8 • 7:02 PM EDT • Technology • gsmarena.com
Connect at Clyde event fosters networking opportunities with business leaders

It was all business today at Clyde Iron Works for a luncheon, to talk networking and opportunities.

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Sep 8 • 6:42 PM EDT • Business • fox21online.com
Ohio cannabis store voluntarily closes as state investigates ‘serious health events’

Arizona-based Vext Science said late last week it had voluntarily shuttered a cannabis store in Jackson, Ohio amid a health investigation.

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Sep 8 • 6:21 PM EDT • Health • mjbizdaily.com
WATCH LIVE: 2026 Republican Midterm Convention
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Sep 8 • 6:04 PM EDT • Politics • pbs.org
Colts Part Ways With 29-Game Starter

Jaylon Jones did well to turn himself from a seventh-round pick into a consistent contributor the Indianapolis Colts. Those contributions didn’t end up being big enough, though. The Colts waived Jones on Tuesday. It was part of a three-pronged roster move that the Colts announced in an official press release like this: “The Indianapolis Colts […] The post Colts Part Ways With 29-Game Starter appeared first on HEAVY.

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Sep 8 • 5:33 PM EDT • Sports • sports.yahoo.com
Fashion, food and fun combine to make this event a success

arc THRIFT STORES Denver News: “Let’s Celebrate” was the theme for arc Thrift Stores’ annual fundraiser, and it’s not a stretch to say that’s exactly what everyone did at this Sept. 3 gathering held at Denver Botanic Gardens. The crowd that filled the gigantic tent overlooking the UMB Amphitheater launched the celebration with a social hour where good conversations, along […]

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Sep 8 • 5:28 PM EDT • Politics • coloradopolitics.com
Should Kids Have Mental Health Days?

With the school in session, some kids will eventually need to take a sick day. But what about a mental health day? A psychologist explains why those are important too.

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Sep 8 • 5:22 PM EDT • Health • newsroom.clevelandclinic.org
Justin Leventhal: A free market needs prices

Price transparency will not fix every distortion in healthcare, but without it, no serious market reform can work.

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Sep 8 • 5:15 PM EDT • Health • twincities.com
Savannah Square Pops celebrates 10 years with community event

Ten years, one local business: Savannah Square Pops is inviting the community to celebrate Thursday

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Sep 8 • 4:57 PM EDT • Business • wjcl.com
Colisée’s new owners pledge to ‘bring life back’ to Lewiston’s top entertainment, sports venue

The New York-based owners say the sale signifies a serious future investment in professional hockey in the city, as well as youth hockey, community events and more.

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Sep 8 • 4:44 PM EDT • Entertainment • sunjournal.com
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Fact-checking Trump's stories about his own 9/11 response

President Donald Trump recounted his response to the Sept. 11, 2001, attacks in an interview and event leading up to the 25th anniversary this week, repeating statements that lack evidence about aiding in the recovery.

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Sep 8 • 4:44 PM EDT • Politics • pbs.org
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Apple event expected to deliver foldable iPhone and debut of new CEO John Ternus
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Sep 8 • 4:25 PM EDT • Technology • cbsnews.com
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No-cost men’s health ‘Lunch and Learn’ coming to Monroe on Sept. 11

Ochsner LSU Health Monroe announced it is hosting a no-cost Men’s Health Lunch and Learn on Friday, Sept. 11, focusing on preventative care and wellness.

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Sep 8 • 4:03 PM EDT • Health • knoe.com
Trump Tells Weird Lie About Where He Was on 9/11

At an event honoring first responders, Trump claimed he was carried away from Ground Zero by firefighters, which didn’t happen.

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Sep 8 • 4:02 PM EDT • Politics • nymag.com
WATCH: Trump remembers 9/11 victims and heroes at Steel Across America anniversary event
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Sep 8 • 3:39 PM EDT • Politics • pbs.org
Kids are back in classrooms. Health misinformation could shape the school year.

Public health officials and medical experts worry that declining vaccination rates will lead to more children getting infected with preventable diseases.

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Sep 8 • 3:38 PM EDT • Health • 19thnews.org
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Cowboys trade rumor could lead to blockbuster in-season deal

The Dallas Cowboys could be in for an eventful start to the 2026-27 NFL season.

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Sep 8 • 3:20 PM EDT • Sports • sports.yahoo.com
Nurses throughout Jefferson Health System announce plan to unionize

More than 200 nurses throughout the Jefferson Health System plan to file to unionize, organizers said during an event on Tuesday.

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Sep 8 • 1:57 PM EDT • Health • nbcphiladelphia.com
AI for better food safety: How tech helps uncover emerging outbreaks

Food-safety expert Willette M. Crawford discusses AI's role in preventing outbreaks and calling for recalls. She said regulatory challenges remain.

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Sep 8 • 1:53 PM EDT • Business • businessinsider.com
Area high school girls flag football players join GN Sports to talk about event this weekend
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Sep 8 • 1:52 PM EDT • Sports • sports.yahoo.com
Apple Releases iOS 26.6.2

Apple today released iOS 26.6.2 with a fix for "an issue that prevents downloading a software update over a cellular connection". The minor software update is rolling out now for the iPhone 11 series and newer. To update your iPhone, open the Settings app and tap on General → Software Update. It might take a few minutes until the update is visible to everyone. iOS 26.6.2 arrives approximately three weeks after iOS 26.6.1, which delivered security fixes.

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Sep 8 • 1:47 PM EDT • Technology • macrumors.com
How to watch Apple's foldable iPhone announcement

Apple's annual iPhone event will stream live on September 9 at 10 AM PDT, and we're expecting big news.

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Sep 8 • 1:46 PM EDT • Technology • techcrunch.com
Apple releases iOS 26.6.2 for iPhone, here’s what’s new

On the eve of its big iPhone launch event, Apple has just released a new iOS 26.6.2 software update for...

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Sep 8 • 1:36 PM EDT • Technology • 9to5mac.com
Apple Event Tomorrow: iPhone 18 Pro and iPhone Ultra Cheat Sheet

Apple's biggest event of the year is almost here, and all eyes are on Cupertino. With the first foldable iPhone expected to headline Apple's "Surprise and Shine" event on Wednesday, September 9, at 10:00 a.m. Pacific Time, the rumor mill has been running full throttle, fuelled by the biggest single design change in the life of the iPhone.

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Sep 8 • 1:24 PM EDT • Technology • macrumors.com
Growing girls sports in South Dakota

SIOUX FALLS, S.D. (KELO) — The visibility of volleyball and women’s basketball is only growing in South Dakota. South Dakota State hosted Sioux Falls native Bergen Reilly and volleyball powerhouse Nebraska on Sept. 2. It was the highest attended event in First Bank and Trust Arena’s history. The Sanford Pentagon sold out the state’s first […]

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Sep 8 • 1:15 PM EDT • Sports • sports.yahoo.com
Health: The Fight For The Health Of 9/11 First Responders

A quarter century after 9/11, the health of those who responded to the attacks continues to be affected.Some 3,000 people died across three locations that day. An estimated 400,000 people were exposed to toxic contaminants and risked physical injury in the hours and days that followed. That’s according to data from the Centers for Disease Control and Prevention.Since the dust and debris have settled, more than 96,000 have been diagnosed with physical and mental health conditions related to 9/11.In 2010, President Barack Obama signed the James Zadroga 9/11 Health and Compensation Act, establishing the World Trade Center Health Program and reopening the 9/11 Victims Compensation Fund. Today, more than 150,000 people are enrolled in the program.But that program wouldn’t exist without the advocacy of survivors and first responders who put their bodies and lives on the line following the attacks. How did that fight for care unfold?For more information about the Rutgers WTC Health Program, click here. And to learn more about applying, click here.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.

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Sep 8 • 1:07 PM EDT • Health • npr.org
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Apple Event 2026 Live: The First Foldable iPhone, iPhone 18 Pro, Apple Watch 12 and More

We're counting down to Apple's Sept. 9 unveiling of the foldable iPhone Ultra. It's the first keynote helmed by new Apple CEO John Ternus and expected to be Apple's biggest event in years.

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Sep 8 • 1:06 PM EDT • Technology • cnet.com
New law to force tech firms to prevent children from taking nude images

The government said it will legislate "as soon as they can" but may "reassess" its plans if firms make the desired changes sooner.

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Sep 8 • 12:48 PM EDT • Technology • bbc.com
Is Trump’s midterm convention a flop before the doors even open?

Trump says he wants to energize Republican candidates before the midterms. Dozens are keeping their distance anyway.

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Sep 8 • 12:39 PM EDT • Politics • theweek.com
Mercy health fair brings vital medical checkups and nutritional aid to Heartland families

The event is designed to provide critical medical screenings, vaccinations, and wellness resources to Heartland families.

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Sep 8 • 12:35 PM EDT • Health • kfvs12.com
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STHS Hosting Webinar on Prostate Health & Early Detection, Sept. 15th

Between busy work schedules, family obligations and other daily demands, many men prioritize the needs of others before their own, often postponing annual checkups and routine preventive screenin

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Sep 8 • 12:24 PM EDT • Health • megadoctornews.com
Chinese giants Xiaomi, Huawei race to get ahead of Apple’s rumored foldable iPhone

Xiaomi and Huawei launched new foldables ahead of Apple’s event, where the company is rumored to unveil its first foldable iPhone.

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Sep 8 • 12:11 PM EDT • Technology • cnbc.com
HHH fundraising dinner tickets now available

OSCODA – Huron Housing Hope (HHH) is inviting the community to attend a fundraising dinner on Sunday, Oct. 4, for which tickets are now available. The event will be held

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Sep 8 • 12:10 PM EDT • Entertainment • iosconews.com
Senior Health Fair set for Sept. 11 in Flower Mound - Cross Timbers Gazette | Southern Denton County | Flower Mound

Southern Denton County residents age 50 and older can connect with dozens of health and wellness resources during the 2026 Senior Health Fair this Friday, Sept. 11, in Flower Mound. The Flower Mound Seniors in Motion Auxiliary will host the annual event from 9 a.m. to noon at the Flower Mound Senior Center. Admission is […]

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Sep 8 • 12:08 PM EDT • Health • crosstimbersgazette.com
What to watch as Republicans gather in Dallas for Trump's unusual midterm convention

President Donald Trump and thousands are expected to arrive in Dallas this week. What to know about candidates, road closures and security

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Sep 8 • 12:01 PM EDT • Politics • nbcdfw.com
How 9/11 Shaped Public Health Preparedness

Hear from Meredith Allen, vice president of Health Security, as she reflects on the tragic event of 9/11, response efforts, and the impact on public health preparedness.

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Sep 8 • 12:00 PM EDT • Health • astho.org
Apple to Introduce All-New 'Readiness' App Tomorrow

Apple plans to announce an all-new "Readiness" app during its "Surprise and Shine" event this Wednesday, according to Bloomberg's Mark Gurman. In a social media post today, Gurman said the "Readiness" app will be a "variant" of the existing Vitals app on the Apple Watch. "The idea is to better compete with software from Whoop and Oura," he said.

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Sep 8 • 11:55 AM EDT • Technology • macrumors.com
Current events: Scientists keep close eye on Atlantic Ocean changes

The year is 2060. London shudders through months of Nordic winter freezes. Across northern Europe, oak and beech forests wither under severe frost and drought, while cereal yields collapse from temperatures ...

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Sep 8 • 11:40 AM EDT • Science • phys.org
Where on Earth is safest from global catastrophe?

Researchers have worked out the safest, most resilient country to be in during an apocalyptic event.

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Sep 8 • 11:39 AM EDT • Science • livescience.com
Best Bets: A quick guide to La Jolla entertainment and experiences

Local events and activities

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Sep 8 • 11:00 AM EDT • Entertainment • sandiegouniontribune.com
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.

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Sep 8 • 10:50 AM EDT • Science • fiercebiotech.com
Republicans descend on Dallas for midterm convention

Dallas is hosting the GOP midterm convention this week.

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Sep 8 • 10:49 AM EDT • Politics • spectrumlocalnews.com