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Khalid Robinson takes next step as Warriors' head coach for NBA Summer League
As he enters his 11th season with the Warriors, Khalid Robinson is about to step into a new role as Golden State's NBA Summer League head coach
Old Home Week Parade rolls through Punxsy
PUNXSUTAWNEY — One of the highlights of the summer, the Punxsutawney Old Home Week Parade on Mahoning Street in downtown Punxsutawney, was held on Saturday afternoon under partly sunny skies
Why the Sixers Will Do Business Before Free Agency Begins
No, it's not flashy. But it will be the final table-setting business for them to handle before they can engage in this summer's free agency sweepstakes.
Laredo Public Health issues summer food, pool safety reminders
Laredo Public Health is reminding residents of food and pool safety steps as warmer weather increases the risk of foodborne illness.
Arkansas Department of Health urges caution during extreme heat
Now that it is officially summer, state health officials want to make sure you're on guard against the extreme heat.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Yan Diomande chooses PSG as next destination if he leaves RB Leipzig
Diomande registered 12 goals and nine assists for Leipzig, who he only joined last summer from Spanish side Leganes.
🚨 BREAKING: Robert Lewandowski agrees multi-year deal with Chicago Fire
Major League Soccer looks set to add another iconic veteran presence to its ranks this summer, with Polish legend Robert Lewandowski reportedly primed for a move to Chicago Fire.Per The Athletic, the ...
Panthers rookie WR shares his offseason work in highlight tape
Panthers rookie WR Chris Brazzell II impressed at spring workouts, and he hasn't slowed down during his summer break. Check out his highlights . . .
Executive Summary: Slowing down, listening a part of Gehrig’s leadership
Editor’s note: The Fort Smith Metro Daily News Executive Summary series is focused on looking under the title, so to speak, of a business, government, and non-profit executive in the...
Business briefs: Free summer health series in Schererville
News and events around the area
Business briefs: Free summer health series in Schererville
News and events around the area
Long Beach reports first West Nile case
The city of Long Beach has reported California's first human case of West Nile virus this summer, according to health officials.
Summer Blockbuster Entertainment
“It’s summertime and the living is easy,” those words sung by Ella Fitzgerald in the 1960s might not ring as true in 2026, but summertime should still be the time […]
3 Traps Health Systems Fall Into When Trying to Improve Their Culture
Cultivating a positive culture is a priority for hospital leaders, but many are making avoidable mistakes. Myra Gregorian, Seattle Children's chief people and transformation officer, outlined some of these common blunders — such as not involving frontline staff in decision making and assuming that simple communication methods are sufficient.
Pharr grocery store to close after nearly 100 years in business
After nearly 100 years in business, the historic M Rivas Supermarket in Pharr is closing its doors, marking the end of a multi-generational Rio Grande Valley legacy.
Grease is the word at Sutter Street
FOLSOM — Sutter Street Theatre will transport audiences back to the halls of Rydell High this summer with its production of “Grease: School Version,” running through July 26.
Popular 9-season sitcom losing its streaming home at end of the summer
The Emmy-award winning series is regarded as as one of the most iconic shows in television history.
‘Odyssey’ fever grips the Classics world
Fans of the ancient world are seizing their moment with the release of this summer’s blockbuster.
Alzheimer’s research headlines 2026 brain health summit
The summit, hosted by the University of Hawaii John A. Burns School of Medicine, highlighted the latest advances in Alzheimer’s research.
Bernstein Says Life Science Sector is Improving, Resumes Thermo Fisher Scientific (TMO) Coverage
Thermo Fisher Scientific Inc. (NYSE:TMO) is included among Billionaire Steven Cohen’s Top 11 Dividend Stock Picks. On June 26, Bernstein resumed coverage of Thermo Fisher Scientific Inc. (NYSE:TMO) with a Market Perform rating. It also set a $520 price target after the analyst returned from maternity leave. In a research note, the firm said “Many […]
Alzheimer’s research headlines 2026 brain health summit
The event featured presentations on recent Alzheimer’s advancements.
MINNEAPOLIMEDIA PRESENTS | This Weekend in the Twin Cities – Entertainment Guide: June 26 ~ June 28, 2026 Edition
Twin Cities Pride, Breakaway, Broadway, concerts, festivals and family fun headline one of summer's biggest weekends across Minneapolis and Saint Paul.
NH businesses feel impact of low summer hiring rates
A new report from the New Hampshire Fiscal Policy Institute shows summer hiring rates are lower than previous years in the Granite State, and two businesses on Hampton Beach are feeling the effects.
Soccer meets nature at Vancouver mountaintop watch party
The match between England and Panama was shown on a big screen atop Grouse Mountain, a 4,100-foot mountain that's part of the Pacific Ranges with a sweeping view of British Columbia. When Jude Bellingham scored England's breakthrough goal in the second half, the fans roared. Both Toronto and Vancouver are hosting matches during the tournament.
Scientists Challenge a Fundamental Assumption About Consciousness
A new philosophical study challenges the idea that consciousness requires human-like biology.
14 unique ways to celebrate America’s 250th birthday
Fireworks, hotdogs and summer blockbuster movies are Independence Day staples. But this year brings a flurry of unique and alternative events where Americans can come together, put aside our differences,
Timberwolves Re-Sign Jaylen Clark to Three-Year Contract
Minnesota brings back its defensive specialist on a team-friendly deal during a summer full of roster turnover.
States seek to lower drug prices by targeting the companies that manage them for health plans
TOPEKA, Kan. — As consumers worry about medication costs, states are trying to lower drug prices by reining in big companies that oversee prescription coverage for health insurers. Some of those companies, called pharmacy benefit managers, also own pharmacies, and one of them, CVS, has spent millions of dollars fighting
Report: Crystal Palace Eye Smart Move for Experienced Arsenal Midfielder
Crystal Palace Eye Christian Norgaard as Arsenal Exit Route OpensPalace Consider Midfield ExperienceCrystal Palace appear ready to offer Christian Norgaard a route out of Arsenal this summer, with Spo...
Harker Heights library places focus on games, science and literacy this week
Enrich your summer with a visit to the Stewart C. Meyer Harker Heights Public Library. The library offers activities and programs for patrons of all ages.
Los Alamos Faith and Science Forum launches 2026 Summer Series - Lutheran Alliance for Faith, Science and Technology
The Los Alamos Faith and Science Forum's 2026 summer season is on, offering weekly presentations on humanity’s most enduring scientific and spiritual questions.
ChaosCollage
Already teaming up for the Chaos Spreads challenge? Submit a screenshot of you and your friends in Minecraft via Gleam.io for a chance to feature in our end-of-summer chaos collage! Find out more in this article
Scratching that bug bite might feel good at first but science explains why it's a bad idea
For the summer itchiness of bug bites and poison ivy, dermatologists recommend hydrocortisone cream, calamine lotion or oatmeal baths.
Sky Sports: Everton are in the race to sign Serie A midfielder
Everton Transfer News: Mandela Keita Emerges as Midfield TargetEverton continue to search for midfield reinforcements this summer, with Sky Sports reporting that Parma’s Mandela Keita has emerged as...
What’s Happening: RI Small business shopping village
This summer, local entrepreneurs and small businesses will have their work on display at Providence Place.
The NHL's Obsession With No-Trade Clauses: Why Hockey Is The Outlier In North American Sports
No-trade and no-move clauses have become so commonplace in the NHL that many fans assume they are simply part of the business of sports. They aren’t.
Marseille look to retain three players
Get French Football News understands that every player at Olympique de Marseille – bar none – is available for the right price this summer. The club overspent under Roberto De Zerbi and the purse...
I tested my workout at Gatorade's sports lab: My 3 hydration mistakes
A sweat test at Gatorade's sports science lab for elite athletes revealed I wasn't consuming enough water, electrolytes, or carbs during workouts.
Hopewell's James Armstrong is the first sophomore to win Post-Gazette Athlete of the Year
James Armstrong is a teenager who doesn’t do well with downtime. Armstrong has a summer job as a maintenance worker at schools in the Ambridge Area...
Where to find free summer entertainment in Boston
Our guide to free summer music, movies, and theater.
California is in for a summer of wild billionaire spending
OPINION: With competing tax measures on the ballot, California billionaires will be spending like... billionaires, political columnist Joe Garofoli writes.
Oklahoma City hosts Day of Sport ahead of hosting games during 2028 Summer Olympics
Oklahoma City welcomed 250 kids to Woodson Park for LA28's Day of Sport, offering them a chance to try Olympic and Paralympic sports ahead of the city hosting events in 2028.
But-For Causation and the Essential Business Hurdle: Analyzing the Summary Judgment in RAAM Construction
RAAM Construction Inc v. United States of America, Case No. 2:25-cv-04681-SPG-AJR, 2026 WL 18391 (C.D. Cal. June 23, 2026). The Employee Retention Credit (ERC) codified under Internal Revenue Code Section 3134 remains a significant source of controversy, audits, and high-stakes federal litigation.
Consumer-Directed Health Care: Promise or Pitfall
This panel will examine the evidence and policy outlook for consumer-directed health care as a federal solution to expanded coverage, with a focus on affordability, access, and health outcomes.
Prediction market Kalshi sues Illinois over its push to regulate sports bets
Article Summary Prediction market Kalshi sued Illinois on Tuesday, seeking to block new taxes and license requirements set to take
CDFW News | Monterey Bay Northern Anchovy and Pacific Sardine Commercial Take Restrictions and Recreational Advisory in Place Due to Public Health Hazard
State health agencies determined that northern anchovy and Pacific sardine recently sampled from Monterey Bay contained elevated levels of domoic acid and recommended a commercial fishery restriction and recreational health advisory in the bay for the take of anchovy and sardine for human consumption in the area.
Lorain flower shop celebrating 75 years as part of International Festival and Bazaar
Lorain has seen businesses come and go, but at least one has stood the test of time. Zelek Flower Shop celebrates 75 years this summer.
The Ship's Sailing on the Best Anker Deals for Headphones, Earbuds, Projectors, and More During Prime Day
One of our favorite brands is seeing huge discounts during Amazon's annual summer mega-sale event. But hurry, as the savings end today!
Canada Inc. Is Ready for a Blockbuster Summer: Five Stories to Watch
Also: What’s behind sky-high bank valuations
Steam Summer Sale Offers Discounts On Hundreds of VR Games
Steam's Summer Sale is offering massive discounts on hundreds of VR titles right now.
Nintendo’s Summer Sale Is Now Live and Not Only Includes Discounts on Digital Titles, but Also the Switch 2 Upgrade Pack for Breath of the Wild
Nintendo has launched a new Summer Sale until July 8. Save on select digital titles across Nintendo Switch and Switch 2, alongside a Switch 2 upgrade pack for Zelda: Breath of the Wild.
Summer Science Program
Explore information about the Summer Science Program at Arkansas Children's Hospital, a career readiness program for college students, including eligibility and how to apply.
Health experts keep Summerfest attendees healthy
On top of staying hydrated and wearing sunscreen, Aurora Health Care encourages wearing comfortable shoes and clothing.
Climbing gym planned in former Summerlin-area movie theater
The gym, which will fill the old Regal Theater on 9400 W. Sahara Ave. in Summerlin, is set to open later this year or early next.
Best Prime Day deals 2026: Amazon's summer sale ends today
We're into the final hours of Prime Day. Don't miss out on our deal highlights from our top-tested picks.
CT Summer Fair brings live entertainment, carnival rides, and more. ‘30,000 expected to celebrate
Suffield’s 6th Annual Summer Fair is running through Saturday, June 27, according to a statement.
Case Studies From Ireland: Making Sustainability Good Business
From Kinisla to Strong Roots, these food companies are making the business case for sustainable practices.
How to Keep Your Skin Healthy and Hydrated in Summer Months
From sunburns to heat rashes, board-certified Dr. Angela Lamb joins TODAY with solutions for common summer skin problems.
Newsom urges a national 'billionaires' tax' while fighting one in California
California Gov. Gavin Newsom is calling for a national “billionaires' tax” and suggests the U.S. government should own a stake in AI companies.
Past participants are now the leaders of MIT’s dynaMIT Club
The MIT student club dynaMIT teaches STEM principles to local middle school students for free every summer. They use fun, innovative experiments to inspire the next generation of scientists and engineers.
2026 SEC football predictions: Game-by-game picks, projecting every team's final win-loss record
Continuing our early-summer projection series for all 16 teams in the SEC and where they'll end up in the postseason
Sam Fuld, player-turned-business exec, is a new Wharton grad. Up next: The Phillies’ future.
Last month, Fuld graduated from Penn's Wharton School and formally assumed his new role as the Phillies' president of business operations.
How Outward Intelligence founders bootstrapped to seven-figure revenue
Three friends with résumés spanning Google, Palantir, and Harris Poll skipped venture capital and bootstrapped their startup instead.
'A heavy impact:' Schwebel's closure leaves a sense of community loss
It’s the small things that residents across the region will remember when Schwebel’s closes its doors at summer’s end. Everything from...
Real Madrid’s summer spending spree creates unexpected Champions League problem
Real Madrid have been one of the busiest clubs in the transfer market, but their impressive recruitment spree may have created a technical issue.Notably, Jose Mourinho has already welcomed four new si...
What could be next for Gakpo?
Following the departure of Mohamed Salah, at least one more attacking signing is expected at Anfield this summer. Liverpool have already signed Victor Munoz from Osasuna for £34.5m and the pursuit of Yan Diomande is heating up. Talented teenager Rio Ngumoha is also set to play a more prominent role, while Florian Wirtz played off the left for Liverpool at times last season and is featuring there for Germany in the World Cup.
Hollywood gets into the microdrama race as mobile-first storytelling draws stars and major studios
While much of Hollywood was consumed by the streaming wars, Issa Rae was studying a different mode of entertainment thousands of miles away: microdramas. No stranger to creating a successful online s...
Q1 Earnings Highlights: Sphere Entertainment (NYSE:SPHR) Vs The Rest Of The Consumer Discretionary - Leisure Facilities Stocks
Earnings results often indicate what direction a company will take in the months ahead. With Q1 behind us, let’s have a look at Sphere Entertainment (NYSE:SP...
Elliot Cadeau appears set to return to Michigan basketball roster
For the third and presumably final time this offseason, Elliot Cadeau appears to have confirmed he will stay with Michigan basketball.
It's Summer Sale Season, So I Tracked Down 25 Actually Good Gaming Deals Under $20
There's a million sales happening right now, so I sifted through them all to find 25 genuinely solid gaming deals that are each under $20.
It's Xbox's turn (again), as console prices keep going up
Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.
The Big Summer Preview – New Ork miniatures and codex are coming
Updated Trukk, Mek and Warboss are on the horizon.
The Big Summer Preview – Chaos Arrives in the Old World
New miniatures, rules, and more revealed for Warhammer: The Old World.
The Big Summer Preview
New jetbikes, grav vehicles and Dreadnoughts revealed for Warhammer 40,000 AND Warhammer: The Horus Heresy.
The Big Summer Preview
See the new edition of Necromunda revealed, including miniatures, rules, and more.
The Big Summer Preview – A New Animation: The Butcher’s Nails
Witness a World Eater in the grip of the Butcher’s Nails.
The Big Summer Preview – See all the reveals here
New reveals for Warhammer 40,000, Kill Team, Age of Sigmar, and more.
The Big Summer Preview – New Starter Sets and ready painted terrain
Dive into Warhammer 40,000, and fight on the battlefields of Armageddon with new terrain kits.
Health officials: State's first West Nile virus-positive mosquito of the year found in Berkshires
“With warmer weather and summer officially beginning this week, it is the time of year when we typically begin detecting West Nile virus in mosquito populations,” a public health official said.
Milly Alcock is Super
Last summer debuted a terrific new Superman. This one lets a Supergirl soar.
Kawhi Leonard Seeks Extension – But Not With Current Team
Kawhi Leonard has one year left on his current contract with the Los Angeles Clippers. He’s eligible to sign an extension this summer, and sounds like he’s willing to do get that done. The one caveat: The Clippers aren’t necessarily the team he wants to sign with. Leonard, who turns 35 on June 29, ...
40+ Steam Summer Sale Games That Are Just $10 Or Less
You can get Dead Island 2, Devil May Cry 5, The Witcher 3, and Ghostwire Tokyo for just $20 right now on Steam
Kentucky State hosts students for agriculture and health science camp
Students from across the country are at Kentucky State University for a summer program focused on agriculture, health and environmental science.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Steam Summer Sale 2026 arrives: 10 hot video game deals
Do you like Star Wars? We have good news.
UToledo Business Camp Hosts Pitch Competition
Dr. Terribeth Gordon-Moore, senior associate dean at the Neff College of Business, discusses the RISE Into Business summer enrichment camp that culminated in teams of high school students pitching their T-shirt business ideas to a panel of judges.
Merck KGaA to Acquire Bio-Techne for $11.3B, Expanding Life Science Tools Presence
Merck KGaA, Darmstadt, Germany, has agreed to acquire Bio-Techne for approximately $11.3 billion, the companies said today, in a deal designed to position the buyer as more of a leader across the life science value chain by expanding its presence in high-growth, next-generation life-sci markets with Bio-Techne’s tools, analytical technologies, and consumables.
Consumer Discretionary Stocks Drawing Institutional Rotation Into Live Entertainment Leaders
With the Federal Reserve hinting at a pause in rate hikes, stubborn inflation still in the background, and several large companies surprising on earnings, consumer discretionary stocks are back in focus for investors weighing risk and opportunity. This article looks at how that mix of easier policy signals, solid corporate reports, and ongoing geopolitical and supply chain issues could affect larger U.S. consumer-focused companies. It will walk through 3 stocks from a curated screener that...
Steam Summer Sale 2026 is live
The great big sale event of the hot season has landed, the Steam Summer Sale 2026 is live now with masses of games featuring big discounts.
Waterloo's Grout Museum District to demolish its Bluedorn Science Imaginarium amid funding changes
This summer, the Grout Museum District is preparing to demolish its former science center, the Bluedorn Science Imaginarium. The decision was made in the face of funding uncertainty stemming from property tax reform in Waterloo.
Entertainment: Card Shows, Bike Races and More
Plus: Don't forget the second weekend of Summerfest.
Spring Sports Roundup
Colby's student-athletes enjoy a season of success and achievement Colby's student-athletes enjoy a season of success and achievement
Yoga, Vinyl & Family Fun: Free Summer Entertainment Returns to Hudson Yards
NEW YORK CITY (PIX11) — Hudson Yards Turns Into NYC’s Outdoor Playground This Summer.
Teen Entrepreneurs Develop, Pitch T-Shirt Businesses at Neff College of Business
The RISE Into Business summer enrichment camp brought teams of high school students to campus to explore marketing, finance, accounting and other core business skills.
'This is the next jump in technology': World's first sub-1nm chip keeps Moore's Law alive a little longer
IBM's NanoStack architecture has helped scientists cram 100 billion transistors onto a computer chip, delivering 50% better performance and consuming 70% less energy than the current generation.
US economy grew at 2.1% in first quarter
First-quarter GDP grew at 2.1%, above the expected 1.6%, as equipment investment in AI and computers along with consumer spending led growth.
NJ Legislators Push for End to Corporate Money in Politics
NJ Legislators Push for End to Corporate Money in Politics New Legislation Would Redefine “Corporation” Under State Law to Disallow Political Spending SUMMIT, N.J.—Assemblymembers Andrew Macurdy, Chigozie Onyema, and Maureen Rowan today announced a bill that would bring an end to corporate spending on politics in New Jersey. The bill alters the definition of “corporation”[...]
Summertime screen time health and safety reminders
There’s no magic number when it comes to screen time. It’s about safety, regulation, and long-term impacts.