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KC has no answers for Jaxon Smith-Njigba on SNF
Jaxon Smith-Njigba led all players in targets, receptions, and total yards as part of a dominant effort versus the Kansas City Chiefs in Week 7.
Cris Collinsworth Turns Heads With Unusual Praise of Patrick Mahomes
Announcer Cris Collinsworth was criticized after he praised Chiefs quarterback Patrick Mahomes for recovering a fumble. The post Cris Collinsworth Turns Heads With Unusual Praise of Patrick Mahomes appeared first on HEAVY.
Chiefs Announce Historic Travis Kelce News During Seahawks Game
Kansas City Chiefs tight end Travis Kelce can’t stop making NFL history.With his third reception in the fourth quarter against the Seattle Seahawks on Sunday night, Kelce has passed Hall of Famer Tony Gonzalez for the most receiving yards by a tight end ever, including the postseason, with 13,342.Kansas City Chiefs’ Travis Kelce is Most […] The post Chiefs Announce Historic Travis Kelce News During Seahawks Game appeared first on HEAVY.
China’s political elite gather for talks on Communist Party discipline
The four-day meeting is being watched closely for clues as to the country's direction and future leadership.
Younha ends C9 Entertainment contract over unpaid earnings
Youngha's exclusive contract with C9 Entertainment was terminated on Sept. 14. The singer has also filed a lawsuit to recover her unpaid earnings and intends to resolve the remaining issues through legal proceedings.
iPhone Duo vs. Samsung Galaxy Z Fold 8: Which foldable is the best?
Can't decide between iPhone Duo and the Samsung Galaxy Z Fold 8? Here's our verdict
Franciscan Health receives stuffed animals for pediatric patients across Northwest Indiana
NORTHWEST INDIANA — Pediatric patients in Franciscan Health emergency rooms, pediatric inpatient units and outpatient surgery centers in Michigan City, Chesterton, LaPorte, Dyer and Munster will now have stuffed animals to help make their hospital experience a little more comfortable, thanks to a donation by The Eva Martin Project. Representatives from The Eva Martin Project recently donated more than 1,400 new stuffed animals to the nonprofit Catholic healthcare system during a drop-off at Franciscan Health Michigan City. Each item has a tag with the organization’s logo and a QR code with a personal message on the back. The nonprofit organization
Derrick Harriott shaped and preserved our music
Minister of Culture, Gender, Entertainment and Sport Olivia Grange has said that, with the death of Derrick Clifton Harriott, Jamaica, sadly, has lost another of the icons who helped to shape the trajectory and reach of the country’s musical genres. Derrick Harriott was a producer, singer, and record distributor who contributed to the development of the ska, rocksteady and reggae genres. He died Saturday morning. He was 87 years old.
Lorna Goodison wins 2026 Derek Walcott Prize for Poetry
Celebrated Jamaican poet Lorna Goodison has added another prestigious international honour to an already distinguished literary career, winning the 2026 Derek Walcott Prize for Poetry for her ground-breaking new translation of the 14th-century classic, Dante’s Inferno. Goodison, Jamaica’s first female Poet Laureate, serving from 2017 to 2020, receives the US$2,000 prize for a work that boldly transports Dante’s epic journey into a Caribbean landscape, drawing deeply on Jamaican language, culture, history and identity.
How to Manage Symptoms of Heart Failure
(Feature Impact) Americans are facing a growing health challenge, with 1 in 4 adults at risk of heart failure, according to the Heart Failure Society of America. Additionally, approximately 6.7 million U.S. adults who are 20 years old or older are currently living with heart failure, and that number is projected to reach 8.7 million by 2030. googletag.cmd.push(function() { googletag.display('JGFI_Article_300x250'); }); Managing heart failure is a significant expense to the U.S. healthcare system, costing the nation approximately $40 billion in 2020 and expected to increase to approximately $142 billion a year by 2050.If you (or a loved one) are living with the condition, consider these tips to help manage it.Adhere to the Treatment and Follow-Up PlanOngoing outpatient care is important when managing heart failure. Understand the treatment plan provided by your healthcare team, make diet and lifestyle changes, take medications as directed and keep recommended follow-up appointments.Pay attention to changes in symptoms and communicate with your healthcare provider if treatment does not seem to be working as expected. If their conditions are left unmanaged, patients can experience a range of heart-failure-related symptoms such as shortness of breath, fatigue, buildup of fluid and more.Understand Challenges with Diuretic TreatmentDiuretics help the body remove excess fluid and are commonly used to treat swelling, or edema, associated with heart failure. Your provider may try different diuretics, sometimes referred to as “water pills,” to manage your heart failure symptoms. However, intravenous (IV) diuretic therapy may be required for some patients if symptoms continue.Ask About Treatment Options Before IV Care Is NeededFor some adults, a healthcare provider may consider recommending an at-home, non-oral diuretic option prior to escalating to IV therapy.For example, ENBUMYST™ (bumetanide nasal spray) is a prescription diuretic used in adults to treat edema associated with congestive heart failure. It’s administered as a nasal spray for short-term use to manage excess fluid with the goal of transitioning to oral diuretic therapy when appropriate.Talk with your healthcare provider to learn more and visit enbumyst.com. Read the full Prescribing Information and Patient Information.Photo courtesy of Shutterstock googletag.cmd.push(function() { googletag.display('JGFI_Article2_300x250'); }); Important Safety InformationWhat is ENBUMYST?ENBUMYST is a prescription medicine used in adults to treat swelling caused by excess fluid in the body (edema) from congestive heart failure, liver disease, and kidney disease.What is the most important information I should know about ENBUMYST?ENBUMYST is a diuretic that helps your body remove fluid. Losing too much fluid can cause dehydration, low blood volume, and increase the risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The risk of these abnormalities is higher in elderly people, those using higher doses, or those who do not get enough electrolytes by mouth.You should not use ENBUMYST if you have severe electrolyte loss. Tell your healthcare provider if you experience unusual thirst; dizziness or lightheadedness; weakness or tiredness; fast heart rate; dry mouth or tongue; sudden pain; redness or swelling in your joints; pain, swelling, redness, or warmth in your leg; shortness of breath or fast breathing; high blood sugar; dark urine; pale, tight, cool or clammy skin; muscle cramps; confusion.Do not use ENBUMYST if you have low or no urine production or are allergic to bumetanide or to any of the ingredients in ENBUMYST.Before using ENBUMYST, tell your healthcare provider if you have low electrolytes, are on a low-salt diet, have diarrhea, diabetes, nasal problems such as a runny or stuffy nose or polyps, a history of nasal injury or surgery, are or plan to become pregnant, are or plan to breastfeed.Tell your healthcare provider about all the medicines you take, including prescriptions, over-the-counter medicines, vitamins, and herbal supplements.ENBUMYST may cause serious side effects, such as worsening kidney function and ringing in the ears or hearing loss.The most common side effects of ENBUMYST include dehydration, headache, muscle cramps, dizziness, low blood pressure, nausea, and abnormal brain functioning with certain liver problems.These are not all the possible side effects of ENBUMYST. Talk to your healthcare provider for more information.Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.US-ENBU-2600110 googletag.cmd.push(function() { googletag.display('JGFI_Article3_300x250'); });
Updated cast makes ‘The Social Reckoning’ shine
On Oct. 9, “The Social Reckoning” came out in theaters, which is a follow-up to the 2010 film “The Social Network.” Both films catalog events in the life of Facebook,
‘Resident Evil’ film resurrects horror game franchise
The first “Resident Evil” game came out in 1996, and since then, the franchise has been working to bring zombies, creatures and deadly outbreaks to life. For the newest piece,
The Rise of Independent Voters Is Reshaping American Politics
In this Fulcrum Roundtable discussion, Jeremy Gruber of Open Primaries explains why voters are leaving the major parties, how closed primaries limit participation, and what reforms could expand representation for nearly half the country.
LLMs Recommend Far More Care Than Doctors
Sometimes a serendipitous study is just what the doctor ordered, especially when you need evidence to support your case on AI alignment.
How Lula beat Bolsonaro, broke records and halted the right-wing wave aligning Latin America with Trump in 20 days
Luiz Inácio Lula da Silva made history on Sunday, setting a record for Brazil and the rest of Latin America by becoming the first president to win a fourth term – and he did so days before turning 81, an age when many other leaders decide to leave politics behind.
China's Rise in Science as a Source of Strategic Power
China is on course to lead the world in research and development, a shift with direct consequences for technological competition and the balance of global power. That is the conclusion of a news feature by Xiaoying You in Nature, published on October 14, 2026. The scale of the change is striking. In 1978, researchers in […]
Following the Science
Robert Royal: True science and faith complement each other by recognizing higher orders of reality.
US has plans for major Iran strikes if Trump chooses
US forces in the Middle East are prepared to launch new, potentially major, military operations against Iran “within 96 hours of receiving” an order from President Donald Trump, according to two US officials.
Jaylen Waddle totals four receptions in Week 7
Denver Broncos wide receiver Jaylen Waddle posted four receptions for 48 yards on a team-high seven targets in Week 7
Trey McBride piles up 10 receptions in loss to Denver
Arizona Cardinals TE Trey McBride busy in Week 7 loss to Broncos
Amynta completes agribusiness push with Southern States acquisition
The deal adds a more than 70-year-old MGU and an exclusive reciprocal distribution arrangement to Amynta’s growing specialty platform
Rashid Shaheed leaves Week 7 with knee injury
Seattle Seahawks wide receiver Rashid Shaheed posted two receptions for just one yard on three targets in Week 7
Three new members join Endowment for Health’s board of direc...
Zach Palmer, Alex Mason and Julia Williams joined the Endowment for Health board Oct. 1, bringing banking, community development and health care leadership expe...
Three new members join Endowment for Health’s board of direc...
Zach Palmer, Alex Mason and Julia Williams joined the Endowment for Health board Oct. 1, bringing banking, community development and health care leadership expe...
Ashton Jeanty catches TD in Week 7 loss
Las Vegas Raiders RB Ashton Jeanty has busy day as a receiver against Rams in Week 7
World-First Cancer Vaccine Cuts Melanoma Recurrence or Death Risk by 42% in Landmark Trial
"This has not been achieved before in the history of cancer drug development."
Arkansan visits Washington, supports push to improve female veterans’ healthcare
WASHINGTON -- An Arkansas veteran was part of a recent push urging Congress to consider legislation to improve healthcare for women veterans.
Jaylin Noel dealing with turf toe injury
Houston Texans wide receiver Jaylin Noel suffered a turf toe injury in the Week 7
Tucker Kraft scores TD in Week 7 vs. Lions
Green Bay Packers tight end Tucker Kraft finished with four receptions for 48 yards and a touchdown on six targets in Week 7
Celtics’ Joe Mazzulla Addresses Growing Tatum-Brown Tension
For years, Boston Celtics fans have wondered whether Jayson Tatum and Jaylen Brown were friends off the basketball court. Following Brown’s recent comments to the media, it’s become clear that even if they were, that isn’t the case anymore.On Sunday, October 25, Celtics’ head coach Joe Mazzulla was asked about Brown’s recent comments regarding Tatum […] The post Celtics’ Joe Mazzulla Addresses Growing Tatum-Brown Tension appeared first on HEAVY.
Georgia lands son of music star in notable recruitment win
Georgia football secured a notable win during its bye week Sunday. And in the process, coach Kirby Smart and company win over fans of country star Luke Bryan. That’s because his son Bo Bryan is joining the 2027 recruiting class. The three-star quarterback chose the Bulldogs officially, becoming the newest College Football Recruiting win for […] The post Georgia lands son of music star in notable recruitment win appeared first on ClutchPoints.
Luka Doncic 50-Bomb Keeps Lakers’ Perfect Start Intact
Los Angeles Lakers guard Luka Doncic recorded a 52-point double-double in the Lakers' 132-123 win over the Utah Jazz on Sunday. The post Luka Doncic 50-Bomb Keeps Lakers’ Perfect Start Intact appeared first on LA Sports Report.
Man completes 12,000-mile walk across America’s four corners in Lubec for mental health awareness
Kyndal Ray Edwards, a mental health coach from Jacksonville, Florida, crossed the finish line at West Quoddy Head Lighthouse in Lubec on Sunday afternoon after visiting all four corners of the contiguous United States. Along the way, he raised funds for the nonprofit Never Alone Recovery.
Vandalia Health recognized for digital health achievement
Vandalia Health earned Level 9 recognition in both acute and ambulatory care in the 2026 Digital Health Most Wired Survey.
Arizona business opens doors for employees with criminal records
An Arizona-based luxury door manufacturer is prioritizing hiring formerly incarcerated individuals to help them successfully re-enter society.
Windows 11’s new “better performance” toggle shows up, but your current PC will never be able to use it
Windows 11's recent preview builds include a new toggle called "Advanced Performance Extensions," aka "APX," and on supported hardware.
Johnson County Focus on Youth Fund promotes access to children’s mental health resources
This is an installment of a series exploring youth mental health. The Daily Iowan has received a grant and is partnering with the Solutions Journalism Network to explore the topic. The Johnson County Focus on Youth Fund has been promoting access to children’s mental health resources by providing funding for families who can’t afford services....
Te Whatu Ora seeks digital tool to redirect ED patients
This comes as a new industry report warns of a crisis in New Zealand's emergency care system.
Local business expert recommends reporting scams via BBB scam tracker
The Better Business Bureau warned the public about phishing scams and advised consumers to regularly check their bank and credit card statements to identify fraudulent activity.
Local business expert recommends reporting scams via BBB scam tracker
The Better Business Bureau warned the public about phishing scams and advised consumers to regularly check their bank and credit card statements to identify fraudulent activity.
Wan'Dale Robinson held to seven yards in Week 7
Tennessee Titans wide receiver Wan'Dale Robinson posted four receptions for just seven yards in Week 7
Phantom Blade Zero review: dark wuxia martial arts masters with an apprentice's execution
S-Game's Unreal Engine 5 'kungfupunk' debut can't help but get tangled in frustrating design choices.
Jenna Ortega ‘almost fell on’ her face after shooting ‘Iron Man 3’ film debut (exclusive)
Jenna Ortega recalls ‘limping’ home and nearly falling on her face after shooting her film debut in ‘Iron Man 3.’
Teddy Roosevelt Erred on Neanderthals
Just recently, paleontologists have found Neanderthal wooden tools (62-40 kya) preserved in stone.
Health network adding helicopter in rapid Pennsylvania expansion
WESTMORELAND COUNTY, Pa. (WHTM) — Not long after they acquired five Pennsylvania hospitals, a health system will soon launch an air medical helicopter in the Keystone State. WVU Health System recently...
Denzel Boston quiet in Week 7 road win vs. Titans
Cleveland Browns wide receiver Denzel Boston registered three receptions for 27 yards on eight targets in Week 7
Edmonds Serves spotlight: Verdant Health Commission
The City of Edmonds is shining the spotlight on those recognized through Edmonds Serves, an initiative honoring all those who serve our community. This week it’s Deana Knutsen of the […]
Xbox console users will receive 50 games from October 26 to 31.
From October 26th to 31st, the Xbox ecosystem and Xbox PC service will receive a major expansion of their catalog, including the release of 50 new games for...
Isaiah Likely disappoints in Week 7 vs. Texans
New York Giants tight end Isaiah Likely limited to two receptions for 12 yards on four targets in Week 7
Sunday Sports: Section 3 football matchups announced and more
Here’s a recap of your North Country sports this Sunday.
TMSM Weekly Recap: Star Wars Super Bowl, Cap Lifts Thor's Hammer, Halloweentown 5 and More
Missed anything? Here are the biggest Disney stories from October 18 to 24, from Star Wars Funday Football and Avengers: Doomsday to Halloweentown 5 and Gideon's new trading cards.
Matthew Stafford breaks Rams franchise record for touchdown passes
LAS VEGAS (AP) — Matthew Stafford added another milestone to his NFL career on Sunday, throwing his 155th touchdown pass for the Los Angeles Rams to break the franchise record.Stafford surpassed Roman Gabriel, who threw 154 TD passes for the Rams from 1962-72.
Jaylin Noel goes backward in Week 7 vs. Giants
Houston Texans wide receiver Jaylin Noel posted two receptions for minus-3 yards on two targets in Week 7
The Next FRIDAY THE 13TH Movie Can Finally Fix An Infamous Mistake
We don’t know precisely when, but a new Friday the 13th movie is coming. After a 17-year drought, the franchise has come back to life, most recently with the release of Crystal Lake on Peacock, a show...
Marvin Harrison Jr. scores TD vs. Giants in Week 7
Houston Texans wide receiver Marvin Harrison Jr. posted a single 6-yard reception for a touchdown on four targets in Week 7
Nico Collins disappoints in Week 7 vs. Giants
Houston Texans wide receiver Nico Collins posted two receptions for six yards on five targets in Week 7
Dalton Schultz totals five receptions in Week 7
Houston Texans tight end Dalton Schultz posted team highs with five receptions, 45 yards and six targets in Week 7
Aleksandar Vucic: Serbia's veteran ruler felled by student-led movement
The dominant force in Serbian politics for over 14 years, Aleksandar Vucic, who conceded defeat in a snap parliamentary poll on Sunday, rose from the wreckage of strongman Slobodan Milosevic's cabinet...
Cooper Health launches new mobile addiction and recovery program
The program will focus on high-need areas in the city and respond elsewhere when called, helping to connect people to addiction support services. | KYW Newsradio
Chuba Hubbard has decent outing in Week 7
Panthers RB Chuba Hubbard finishes with 33 rushing yards and 27 receiving yards
T.J. Hockenson finds end zone in Week 7 vs. Colts
Minnesota Vikings tight end T.J. Hockenson posted four receptions for 35 yards and a touchdown on five targets in Week 7
Presidential race in Bulgaria heads to runoff due to record low turnout
In a surprisingly strong performance, the candidate of the pro-Western reformist opposition, Andrey Gyurov, will face the incumbent leftist president, Iliana Yotova, setting clear lines of division regarding the country’s future relationships with other nations.
Justin Jefferson limited to 44 yards in Week 7
Minnesota Vikings wide receiver Justin Jefferson had four receptions for a team-high 44 yards on seven targets in Week 7
Four receptions for Chris Godwin Jr.
Buccaneers WR Chris Godwin Jr. leads team with four receptions in Week 7 win
Cleveland Browns rookie WR hits historic mark against Titans
KC Concepcion’s 129 receiving yards places him in the Top 10 for a single game by a rookie in franchise history.
When will Myles Garrett return to the Rams?
Here's the latest on Myles Garrett as he continues recovering from early-season knee surgery.
Bayern beat Freiburg to reclaim top spot after Kompany illness
Bayern Munich reclaimed top spot in the Bundesliga with a 3-1 win at Freiburg on Sunday, days after coach Vincent Kompany was hospitalised when he collapsed at training.With coach Kompany still in hospital after collapsing on Friday, Englishman Danks was in the dugout.
NZ’s hidden chronic health burden is even bigger than we thought
New research reveals a major gap in how chronic illness is measured, with implications for planning and funding healthcare in New Zealand.
Puka Nacua active for Week 7 vs. Raiders
Los Angeles Rams wide receiver Puka Nacua is active for the Week 7 game
Supercurrent enables the reading of quantum information without destroying it
One of the fundamental challenges of quantum computing is obtaining information from a quantum bit, or qubit. Unlike a conventional bit, which can be read repeatedly without altering its content, direct ...
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center
The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.
Defender turns striker and scores in Bayern win
Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...
Windows 11 is apparently so bad that XBOX would rather cancel hardware than be forced to use the OS
A reported clash between Microsoft's XBOX and Windows teams suggests Windows 11's desktop may no longer be the foundation for Project Helix.
Trump on high gas prices: 'We're making a freaking fortune"
Americans, meanwhile, are paying record prices at the pump, according to AAA.
Scientists Develop a Clever New Way To Kill Cancer Cells From the Inside
Scientists have developed an experimental strategy that exploits a chemical byproduct of cancer cells to produce anticancer drugs directly inside them. Scientists in Japan have developed an experimental method that uses a chemical produced by cancer cells to manufacture anticancer drugs directly inside them. The approach relies on carbon monoxide, a toxic gas that certain
Three receptions for Germie Bernard
Steelers WR Germie Bernard catches three of his five targets in Week 7 win
Professor Katherine McNeill Inducted Into Massachusetts Science Educators Hall of Fame
Katherine L. McNeill was inducted into the Massachusetts Science Educators Hall of Fame on Friday in recognition of her two decades of work in science education.
Chris Olave targeted 10 times in Week 7
New Orleans wide receiver Chris Olave went for six receptions for 56 yards on 10 targets in Week 7
‘Clayface’ Ties ‘Obsession’ For A Rotten Tomatoes Audience Score Record
'Clayface' has a Rotten Tomatoes audience score that matches Obsession's a wild achievement for the comic book film.
Nico Williams publicly disavows his agent over Barcelona transfer claims
Barcelona’s long and drawn-out pursuit of Nico Williams has become one of the more familiar sagas of recent transfer windows.The Athletic Club winger ultimately opted to stay at San Mames, snubbing ...
Clatsop County health inspections for September
Clatsop County health inspectors recently completed a round of restaurant inspections that yielded overwhelmingly positive results for most local eateries. But one Seaside establishment received a temporary closure after receiving […]
Business People: Evereve names industry vet Sarah Clary to advise on creative
RETAIL Evereve, an Edina-based women’s fashion retailer, announced it has named Sarah Clary as advisory chief creative officer. Clary previously has led creative direction campaigns and brand strategy for Hill House Home, Veronica…
One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie
Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.
MTSU named among Billboard's Top Music Business Schools for 12th year in a row
Middle Tennessee State University has been named a top music business school by Billboard for the 12th year in a row.MTSU's Department of Recording Industry mad
Buccaneers vs. Panthers Week 7 inactives: Baker Mayfield returns
The Tampa Bay Buccaneers are set to take on the Carolina Panthers Sunday afternoon in a crucial NFC South matchup at Bank of America Stadium in Charlotte. Tampa Bay received some encouraging news ahead of kickoff as quarterback Baker Mayfield is officially active and will start after missing the previous three games with a dislocated […]
In West Maui, Democrat-turned-Republican defends House seat against Lahaina Strong organizer, local business advocate
Incumbent Rep. Elle Cochran, Green Party candidate Pā’ele Kiakona and Democratic nominee Sne Patel are battling to represent West Maui at a pivotal time in the fire recovery.
"It never was entertainment to us, ever. It was always something with a lot more importance and meaning." U2 reveal the unbroken promise that they made to one another as schoolboys in Ireland 50 years ago
"Music is not a matter of life and death, it’s something much more serious than that"
Political cartoons for October 25
Sunday's political cartoons include increasing costs, the White House briefing room, and more
Liverpool 2, Brighton 0 – Match Recap: That Was Actually Fun
A look back at the key moments in Liverpool's great victory over Brighton in Premier League action.
Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
Scientists Discover a Plant Compound That Could Help Stop Rheumatoid Arthritis Inflammation
Scientists have identified a plant compound that reduced joint swelling and inflammation in rats with experimental arthritis. The discovery offers a potential new direction for rheumatoid arthritis tr...
#ESMO26: Merck and Moderna's cancer vaccine data were 'a triumph of science.' And now, the work begins
Merck and Moderna’s intismeran cut melanoma recurrence risk 42% at ESMO; experts weigh other tumors, manufacturing and boosters.
Chair of 'submarine affair' committee probing Netanyahu resigns due to health concerns
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ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Senator, former California Secretary of State Alex Padilla weighs in on voter roll fight
With one week left before the midterm elections, California is facing a federal lawsuit alleging that non-citizens were registered to vote, received mail-in ballots, and, in some cases, voted.
Rumored Lucia Actress Goes Viral After Dodging Swarm of GTA 6 Comments During Livestream
Manni L. Perez, the actress long rumored to be playing Lucia in GTA 6, has gone viral after dodging a swarm of comments from Grand Theft Auto fans during a recent livestream.