SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " omb " 4,526 found 🔀 AI-powered Shuffle
Bill Self says coaching future at Kansas to be determined
Longtime Kansas coach Bill Self said after Sunday's season-ending loss to St. John's that he has not yet made a decision about his coaching future, later adding that any decision will be based solely on his health.
Carrie Anne Fleming, 'Supernatural' and 'iZombie' actress, dies at 51
Carrie Anne Fleming, who appeared on 3 episodes of 'Supernatural' as Bobby's wife Karen, has died. She was 51.
Wisconsin edges Ohio St., wins another title at Frozen Four
Claire Enright scored the go-ahead goal in the third period Sunday, Ava McNaughton had 34 saves, and No. 2 seed Wisconsin beat top-seeded Ohio State 3-2 at the Frozen Four to win its second consecutive national championship.
Notre Dame men join women in winning inaugural three-weapon title
Notre Dame's Ahmed Hesham won the men's saber Sunday, and the Fighting Irish men joined the women in winning the inaugural three-weapon national championship at the Joyce Center.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Trump mocks 'discombobulated' Schumer over Democrats' near gaffe on funding ICE
President Donald Trump mocked Chuck Schumer after the Senate minority leader accidentally said "We must fund ICE" on the Senate floor amid the DHS funding shutdown fight.
iPad 12 With A18 Chip for Apple Intelligence is 'Still Coming This Year'
Apple has updated a wide range of products and accessories this month, but there is still no entry-level iPad 12 with Apple Intelligence support. Fortunately, Bloomberg's Mark Gurman today said an iPad with an A18 chip for Apple Intelligence is "ready to go" and "still coming this year". An earlier report from Macworld claimed that the iPad 12 will actually have an A19 chip.
New Apple TV and HomePod Mini Remain 'Ready' to Launch
Apple has unveiled nine new products this month, but the wait continues for the next-generation Apple TV 4K and HomePod mini models. In his Power On newsletter today, Bloomberg's Mark Gurman said new versions of the Apple TV and HomePod mini have been "ready" since last year, but he reiterated that Apple has held off on releasing them until the more personalized version of Siri and other Apple Intelligence upgrades are released later this year.
Sebastian Kehl exits role as Borussia Dortmund sporting director
Borussia Dortmund sporting director Sebastian Kehl is leaving the team with immediate effect as the club undergoes a major shakeup after what will be a trophyless season.
Acuff scores 36 as Arkansas holds off No. 12 seed High Point 94-88
Two of the highest-scoring teams in the nation combined on a back-and-forth affair that featured 15 lead changes and six ties.
Get ready to vote in the next Detroit Community Choice Awards
The awards program seeks to shine a light on outstanding businesses in Wayne, Oakland and Macomb counties.
In the Fight to Defend the Amazon, This Indigenous Community’s Secret Weapon Is Science
In the copper-rich mountains of southeastern Ecuador, Shuar people are combining ancestral knowledge and modern science to protect their forest from a Canadian mining giant.
Edgecombe's double-double helps 76ers down Jazz 126-116
SALT LAKE CITY (AP) VJ Edgecombe had 22 points and 13 rebounds and Quentin Grimes scored 26 points to lead the Philadelphia 76ers to a 126-116 victory over the Utah Jazz on Saturday night.
Curzan lifts Virginia women to sixth straight NCAA swim title
Claire Curzan finished off a sweep in the backstroke on Saturday to help lead the Virginia women to their sixth straight NCAA swimming and diving championship on Saturday.
Donald Trump Is Nothing Like Robert Mueller
The absurdity of a man who avoided Vietnam due to “bone spurs” dancing on the grave of a decorated combat veteran
Reddit is weighing identity verification methods to combat its bot problem
Steve Huffman, Reddit's CEO, said that using biometrics is the "most lightweight way" to verify that it's a human.
Mainieri out as South Carolina's baseball coach in 2nd season
Paul Mainieri is out as South Carolina's baseball coach midway through his second season after he couldn't approach the level of success he had produced at LSU.
Wisconsin's Caroline Harvey wins Kazmaier Award as top player
Wisconsin defender Caroline Harvey voted as the winner of the Patty Kazaier Memorial Award for college women's hockey's top player.
One All-in-One AI Platform, Endless Business Possibilities for Just $85
1min.AI combines writing, images, and video.
Combating youth suicide tilts increasingly toward early intervention
A suicidal child or teenager may never talk of taking their life. Parents, peers and teachers might not even know they’re living with mental illness. Despite younger generations showing greater openness to discussing mental health struggles, fears of punishment or social exclusion remain, experts say. Even at medical appointments, minors
Alabama's Tyler Fay pitches no-hitter against Florida
Tyler Fay pitched Alabama's first nine-inning, complete-game no-hitter in 84 years, striking out 13 in a 6-0 victory over Florida on Friday night.
Cori Close hails Lauren Betts's 'courageous vulnerability' on mental health
A day after UCLA's Lauren Betts opened up about her mental health journey, head coach Cori Close said she couldn't be "more impressed and inspired" by Betts' "courageous vulnerability."
Mark Robinson admits ‘I lied’ about CNN story
Former North Carolina Lt. Gov. Mark Robinson admitted he lied about a bombshell CNN KFile investigation during the final months of his 2024 gubernatorial campaign, uncovering his extensive history of posting inflammatory and racist comments on a pornography website.
How to watch 2026 NCAA swimming and diving championships
It's time for the 2026 NCAA swimming and diving championships! Here's how to catch the action on ESPN+.
Tilman Fertitta Bid Puts Caesars Entertainment Value And Future In Focus
Tilman Fertitta is reportedly in advanced talks to acquire Caesars Entertainment, ahead of a rival bid from investor Carl Icahn. The potential deal would combine Fertitta's Golden Nugget casino interests and sports assets with Caesars Entertainment's Las Vegas Strip footprint. This development is attracting attention from shareholders as a possible turning point for NasdaqGS:CZR. Caesars Entertainment, trading as NasdaqGS:CZR, last closed at $27.44. The share price return is up 44.8% over...
Claimants drop lawsuit against Gerry Adams over IRA bombings
Three people were suing ex-Sinn Féin leader for liability over IRA bombings in UK which left them injured
New Spider Mimics ‘The Last of Us’ Zombie Fungus Cordyceps
A newly discovered species of spider in the Ecuadorean Amazon mimics a pathogen, known as a zombie fungus, to protect itself.
This Infamous Radioactive 'Tomb' Is Leaking, And Experts Are Worried
"The integrity of the dome could be in jeopardy."
Unilever in talks to combine food business with McCormick, WSJ reports
Unilever is in talks to separate its food business and combine it with spice maker McCormick in an all-stock deal which could come within weeks, the Wall Street Journal reported on Thursday, citing sources.
Unilever in Talks to Combine Food Business With McCormick, Report Says
Unilever Plc, the maker of Hellmann’s mayonnaise, is in talks to combine its food business with McCormick & Co., according to a report in the Wall Street Journal citing people familiar with the matter.
Exclusive | Unilever in Talks to Separate Food Business and Combine It With McCormick
The remaining Unilever company would focus on beauty, personal-care products and home.
High-speed combat drone production starts at new US Anduril plant in days
Anduril Industries will begin building its new FURY, "loyal wingman," high-speed combat drones in the coming days at a new facility in Ohio, as the U.S. military's interest in unmanned aircraft surges following battlefield successes in Ukraine and Iran.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Trump faces his most difficult Iran war decision: Will he deploy U.S. troops to seize uranium?
The president has been circumspect about how far he's willing to go to follow through on his pledge to destroy Iran's weapons program once and for all, including seizing or destroying the near-bomb-grade nuclear material that Iran possesses.
Tokyo Joshi Pro Wrestling celebrates idols and combat at SXSW
The women of Tokyo Joshi Pro Wrestling, making their first-ever stop in Austin during SXSW, put on an unforgettable show.
Bloomberg: Google begins testing dedicated Gemini app for Mac
Mac users who prefer Gemini for their AI interactions might not have to wait much longer for a dedicated app....
Mullin addresses temper, ‘secret’ trip at DHS hearing
The confirmation hearing became combative between Mullin and Sen. Rand Paul
Xiaomi releases new lightweight laptop with Intel Panther Lake and 120 Hz OLED display
Xiaomi has released a new 14-inch laptop featuring Intel's Panther Lake platform. Available with up to 32 GB of RAM, the Book Pro 14 combines a 120 Hz OLED display with 72 Wh battery inside a housing that tips the scales at barely over a kilo.
MLB reaches agreements with Polymarket, federal commission
MLB has named Polymarket as the league's official prediction market exchange and announced an information sharing agreement with the CFTC, the federal body that oversees the growing industry.
Interventional radiology breakthrough in portal vein thrombosis treatment
A UCLA Health interventional radiologist has successfully performed the first pediatric percutaneous spleno-renal shunt procedure to treat severe portal hypertension in a 6-year-old patient. This minimally invasive procedure aims to relieve complications associated with portal vein thrombosis, showing promising long-term outcomes.
3M to create a leading fire and safety business; acquires Madison Fire & Rescue and combines with Scott Safety
/PRNewswire/ -- 3M (NYSE: MMM) announced today that it has entered into a definitive agreement to acquire Madison Fire & Rescue, in partnership with Bain...
This heart-healthy diet may also lower the risk of dementia
Two studies have found the DASH diet — either alone or combined with the Mediterranean diet — is a winner in terms of brain health.
Tanvi, Ayush, Anmol in action at Orleans Masters; SC Delhi face Jamshedpur in ISL: Indian Sports LIVE, March 19
Here are all the updates from Indian sports on March 19, 2026.
HSBC mulls job cuts that could impact around 20,000 roles, Bloomberg News reports
HSBC Holdings Plc is weighing a wave of deep job cuts over the coming years that could ultimately impact around 20,000 roles, or about 10% of its total workforce, Bloomberg News reported on Wednesday, citing people familiar with the matter.
Alumna supports students through sports
Alumna Chrystal Starling has built a dynamic career combining sports, education, and youth development. From Hokie student athlete to professional basketball player to assistant principal at a New York charter school, Starling credits writing and the influence of Nikki Giovanni for helping her find her voice and her purpose.
2026 NCAA women's Frozen Four ice hockey: How to watch on ESPN
The NCAA Frozen Four action will unfold Friday at Penn State's Pegula Ice Arena in University Park, Pennsylvania.
Video: Business Report Hall of Fame honoree Bob Greer
A respected figure in the insurance and banking industries, Robert Stephenson “Bob” Greer Jr. made an indelible impact on Baton Rouge, combining an abiding love for his hometown with ambitious ideas on how to make it better. Greer was recently named a 2026 Hall of Fame laureate (posthumous) by Business Report. Watch the video of Bob […]
Colleges struggle to keep up with growing mental health problems
Depression and suicidal ideation are stubbornly high among college students despite increased efforts by universities to combat the long-growing problem. While nearly all four-…
Anti-Fraud Practices Your Bank Should Teach Every Small Business Customer
Payments fraud against businesses is skyrocketing, but banks and customers can combat it together.
Observations after Sixers start trip with lopsided loss to Nuggets
The Sixers trailed by 33 points during the second quarter of their loss Tuesday night to the Nuggets.
Bangladesh sports minister to consult ICC on future of BCB
Sports minister Aminul Haque said on Tuesday that once the five-member committee submits its report within 15 working days, he will discuss the matter with the ICC | ESPN.com
Srikanth, Ayush in action at Orleans Masters: Indian Sports LIVE, March 18
Here are all the updates from Indian sports on March 18, 2026.
Minnesota fires women's hockey coach Frost after 19 seasons
Minnesota dismissed women's hockey coach Brad Frost on Tuesday after 19 seasons, a decade since the program's last national championship.
A unique combo of two top diets slowed brain aging by over 2 years
A diet focused on the best foods for brain health slowed aging in key parts of the brain by over 2 years, a new study found.
Unilever considers separation of its food assets, Bloomberg News reports
Unilever is in the early stages of weighing a separation of its food assets as the consumer goods maker plans to streamline its business, Bloomberg News reported on Tuesday, citing people familiar with the matter.
Champions League live updates: Arsenal-Leverkusen, Man City-Real Madrid
Enjoy live updates from Tuesday's UEFA Champions League matches, including Arsenal vs. Leverkusen, Man City vs. Real Madrid and Chelsea vs. PSG.
Allina Health, California-based Sutter Health announce intent to combine companies
Trombone emoji designed by Maryland students headed to iPhones everywhere
The trombone emoji designed by a group of Maryland students is headed to iPhones everywhere.
UBS faced technology outage that impacted trading business, Bloomberg News reports
UBS Group has been working to fix a global technology outage that impacted some of its trading business, Bloomberg News reported on Tuesday. Some trading has been halted during the outage, the report said, citing people familiar with the matter. (Reporting by Akanksha Khushi in Bengaluru; Editing by Maju Samuel)
Allina Health to Join Sutter Health, Creating Bold Vision for Nonprofit Healthcare
United by a shared mission, trusted nonprofit health systems have a unique opportunity to advance innovations that strengthen quality and extend care to more patients NORTHERN CALIF. and MINNEAPOLIS — Sutter Health and Allina Health have signed a Letter of Intent (LOI) for Allina Health to join the California-based system, which would create a combined […]
Sutter Health to combine with Midwest provider Allina
The Northern California health giant aims to grow its footprint with a proposed deal bringing Allina’s hospitals in Minnesota and Wisconsin under its umbrella.
Sutter Health looks to combine with Minnesota hospital system
The Sacramento-based health system said it has signed a letter of intent to combine. Officials expect the deal to close by the end of 2026.
Manatt Recruits Nixon Peabody Entertainment Group Chief Heisler
Entertainment lawyers Ellie Heisler, Jessica Boardman, and Mike Lawhead joined Manatt, Phelps & Phillips as partners in Los Angeles, the firm announced Tuesday.
Microsoft combines Copilot teams and moves Mustafa Suleyman to focus on frontier AI models
It's the latest leadership change in a shakeup after a key Microsoft executive announced plans to retire.
Samsung to Discontinue Galaxy Z TriFold After Just Three Months
Samsung is set to discontinue the Galaxy Z TriFold globally after just three months on sale (via Bloomberg). The company will start by ceasing sales of the device in Korea, where it has been on sale since December. Samsung plans to discontinue the device in the United States once it clears its inventory. Samsung's website already lists the TriFold as "sold out," but customers are still able to buy the device at Samsung stores.
Hawks fans sport Magic City gear despite canceled promotion
Hawks fans showed up in Magic City gear Monday night even though the NBA shut down the team's short-lived promotion with the well-known adult entertainment club.
Fields now set for Maine June primaries
Gov. Janet Mills, combat veteran and oyster farmer Graham Platner and David Costello, a former senior level government official, are all competing for the right to face Sen. Susan Collins in the fall.
US race to counter Iranian drones echoes response to roadside bombs in Iraq and Afghanistan
Facing deadly Iranian drone attacks across the Middle East, the US military has been rushing defensive systems into the region while adjusting to a threat that has come to dominates modern battlefields and carries echoes of a weapon that haunted service members during the 20 years of the war on terror.
Accused DC pipe bomber tells court Trump’s broad Jan. 6 pardon should apply to him
The Virginia man accused of planting two pipe bombs in Washington, DC, the night before the 2021 US Capitol riot asked a federal judge on Monday to dismiss his case, arguing that President Donald Trump’s expansive pardon of January 6 rioters applies to him.
Prannoy, Srikanth among Indians at Orleans Masters; Rajasthan United face Real Kashmir in IFL: Indian Sports LIVE, March 17
Here are all the updates from Indian sports on March 17, 2026.
APAC Buy-Side Firms Embrace AI, Automation To Optimize Business Processes | Insights
In this new survey of 50 buy-side firms across Asia-Pacific, Bloomberg and WatersTechnology reveal an industry that has moved decisively past experimentation and into live, production-grade adoption of AI and automation.
Trump said he spoke to a former president about bombing Iran. Four denials suggest otherwise.
Trump said twice Monday that he spoke to one of his predecessors about the Iran war and that the former president said he wished he had taken the action Trump did.
Oregon QB Dante Moore reveals struggles with mental health
Oregon quarterback Dante Moore has revealed he struggled with mental health issues associated with the pressures of major college football.
Merlin and Inflection Point Acquisition Corp. IV Announce Closing of Business Combination
Merlin's Cessna Caravan Merlin's aircraft flying overhead at the company's Quonset, RI hangar Merlin's Quonset, RI Hangar A C-130J flying overhead at Merlin’s Quonset, RI hangar Transaction provides more than $200M in gross proceeds to accelerate commercialization of AI-powered autonomous aviation Merlin to Begin Trading on March 17th on the NASDAQ Under Ticker Symbol “MRLN” BOSTON, March 16, 2026 (GLOBE NEWSWIRE) -- Merlin, Inc., an aerospace and defense technology company building the operatin
Bombshell judgment demands Krafton immediately reinstate ousted CEO and return his authority over Subnautica 2
In a bombshell ruling, a court has ordered Krafton to reinstate former Unknown World CEO Ted Gill, return control of th…
Judge delivers bombshell order for Krafton to reinstate fired Subnautica 2 devs and CEO, putting $250m bonus package back on the table
A judge has ruled that fired Subnautica 2 leads including the former Unknown Worlds CEO must be reinstated, with their $250m bonus package extended.
Oz Says California’s Not Fighting Health Care Fraud. Data Shows a Larger Battle
By Don Thompson | KFF Health News SACRAMENTO, Calif. — For weeks, Mehmet Oz has been waging a public feud with California leaders over health care fraud, accusing the blue state of failing to adequately combat such abuse. Oz, who heads the U.S. Centers for Medicare & Medicaid Services, alleged that
Reed Smith Hires Entertainment, Media Lawyer Malphettes in Paris
Agathe Malphettes joined Reed Smith as a partner in its entertainment and media industry group in Paris, the firm announced Monday.
Colombia’s Real Threat Is Not Political
Colombia’s primary elections left political junkies in ecstasy and economists uneasy.
2 of US' 3 mine-hunting ships for Middle East just seen in Asia
The Independence-class littoral combat ships were seen docked at Penang amid worries that Iran may mine the Strait of Hormuz.
FC Goa face Punjab FC in ISL: Indian Sports LIVE, March 16
Here are all the updates from Indian sports on March 16, 2026.
Cells can sense 10x farther than expected and it may explain cancer spread
Scientists have discovered that cells can sense far beyond the surfaces they touch. While individual cancer cells can probe about 10 microns ahead by tugging on surrounding collagen fibers, clusters of normal epithelial cells can combine forces to detect layers as far as 100 microns away. This long-range “depth sensing” helps cells decide where to migrate. Understanding how it works could reveal new targets to stop cancer from spreading.
Scientists unlock a powerful new way to turn sunlight into fuel
Scientists have developed a powerful new computational method that could accelerate the search for next-generation materials capable of turning sunlight into useful chemical energy. The work focuses on polyheptazine imides, a promising class of carbon nitride materials that absorb visible light and can drive reactions such as hydrogen production, carbon dioxide conversion, and hydrogen peroxide synthesis. By analyzing how 53 different metal ions influence the structure and electronic behavior of these materials, researchers created a framework that predicts which combinations will perform best.
Deputies evacuate Destin Commons area after bomb threat called into business
OKALOOSA COUNTY, Fla. -- Deputies are urging people to avoid the Destin Commons area as deputies investigated a bomb threat called into a business.Deputies were
U.S. completes historic hockey sweep in Olympics, Paralympics
Three weeks after the United States beat Canada in the Olympic hockey finals, the Americans overcame their neighbors again to win Paralympic gold and complete the three-peat at Milan Cortina.
iOS 27 Will Reportedly Be Like Mac OS X Snow Leopard
In his Power On newsletter today, Bloomberg's Mark Gurman reiterated that iOS 27 will be similar to 2009's Mac OS X Snow Leopard, in the sense that one of Apple's biggest priorities is bug fixes for improved performance and stability. At WWDC 2008, Apple showed a presentation that said Mac OS X Snow Leopard had "0 new features," as it opted to focus on performance and stability improvements.
Sources: Atlantic 10 set to hire Dan Leibovitz as commissioner
The Atlantic 10 Conference is set to hire Big East senior associate commissioner Dan Leibovitz as its next commissioner, sources told ESPN.
MacBook Neo 2 With a Touch Screen Has Gone From Yes to Maybe to No
A second-generation MacBook Neo with a touch screen has gone from a yes to a maybe to a no. In his Power On newsletter today, Bloomberg's Mark Gurman said Apple has yet to decide whether to bring touch-screen support to any Macs beyond the next high-end MacBook Pro, which is expected to be released in late 2026 or early 2027. A touch screen would also slightly increase the cost of making the MacBook Neo, which is priced as low as $499, so the laptop will likely remain without one for years.
Living amid bombings in Iran: How fear impacts mental health
Bombs, government oppression, and fear are wearing down Iranians. How does trauma build up? And what can help people living with constant stress?
Arkansas men, Georgia women take home titles at NCAA indoors
Arkansas ran away with the men's team title while Georgia won the women's team crown at the NCAA Indoor Track Championships.
NorthEast United host Jamshedpur, Inter Kashi face Mumbai City in ISL: Indian Sports LIVE, March 15
Here are all the updates from Indian sports on March 15, 2026.
West Virginia repeats, wins program's 21st NCAA rifle title
West Virginia defended its NCAA rifle championship on Saturday, edging out TCU to claim the 21st national rifle title in program history.
Park City Main Street reopened following report of bomb inside local business
Businesses along Park City’s Main Street were evacuated Saturday afternoon following reports that a bomb had been planted inside the Egyptian Theater.Lt. Daniel
White House war promo videos marry action movies, sports and video games to real-life combat footage
Some critics, including an official with the U.S. Catholic Church, have accused the administration of trivializing a real-life conflict.
The US is the number 1 destination for this illegal gold
Gold's value surpassed record highs this year, fueling Colombia's illegal mining boom and drawing US markets deeper into a new criminal gold rush.
Trump says U.S. bombed Kharg Island, striking core of Iran’s oil economy
President Donald Trump on Friday night announced the United States had bombed Kharg Island, targeting Iran’s most critical oil terminal.
Trump says US ‘obliterated’ targets in strike on key Iranian oil hub
Trump said the U.S. bombed Iran’s Kharg Island, a key Iranian oil export hub, and warned against interference in the Strait of Hormuz.
2nd annual mental health summit focuses on support, resources for first responders
The mental health of first responders is getting special attention in western North Carolina during a three-day summit in Buncombe County.
Netanyahu sells regional change as hopes for Iran regime change fade
Israeli leaders are framing the bombing campaign as having transformed the Middle East in their favour as pressure to end the conflict builds.