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Hospital sued after drug addict nurse allegedly causes death of two patients
An emergency department nurse at Heritage Valley Sewickley Hospital is accused of stealing drugs and neglecting patients, causing at least two fatalities. A lawsuit filed by two whistleblowers further alleges that hospital leadership covered for the drug-dependent nurse.
5 things to know about an emerging drug-resistant fungus now putting hospitals at risk of outbreaks
Memo to health execs: If your hospital hasn’t had a C. auris scare yet, odds are quite high that it soon will.
Children’s Hospital Los Angeles’ 2026 TSRI Science Day Highlights Advances in Cancer Biology
June 17 saw more than 400 scientists, clinicians, research staff, and other Children’s Hospital Los Angeles team members come together for The Saban Research Institute’s (TSRI) yearly symposium and poster session—Science Day 2026.
Can GLP-1 medications improve health in people with Type 2 diabetes and PAD?
Research Highlights: GLP-1RA (glucagon-like peptide-1 receptor agonist) medications, which are prescribed to treat Type 2 diabetes and to help with weight loss, were found to reduce the number of deaths, amputations and hospitalizations among people...
North Dakota opens wellness equipment funding opportunity for rural hospitals | Health and Human Services North Dakota
From fitness and recovery equipment to mindfulness tools and wellness spaces that help reduce burnout, North Dakota Health and Human Services (HHS) is investing in the health and well-being of rural healthcare workers through a new funding opportunity for rural hospitals.Applications are now open for the Hospital Wellness Equipment funding opportunity through the North Dakota Rural Health Transformation Program (RHTP), providing resources to help rural North Dakota hospitals create healthier workplaces and support the physical, mental and emotional well-being of their workforce.
Wilmington Small Business Coalition: Building Momentum in 2026 by Heather McWhorter
This article was contributed by Lydia Thomas, UNCW CIE Program Manager. North Carolina continues to be one of the best states to start a business and in 2025, Wilmington, North Carolina earned a spot on the GoDaddy list of the top 10 most entrepreneurial cities in the U.S. While many know Wilmington as small beach town with exceptional food, lots of coffee shops, and fun, vibrant summer activities, a closer look reveals a thriving innovation economy. You’ll find startups emerging across industries including software, healthtech, bluetech, and fintech. At the core of this entrepreneurial ecosystem is the Wilmington Small Business Coalition, with small business advocates and entrepreneur support organizations (ESOs) dedicated to helping founders grow, thrive, and succeed. “No Wrong Door” Established in 2016, the Coalition was designed to make it easier for individuals and small businesses to access resources most suited to their particular needs. The Coalition is designed to have a “no wrong door” entryway into the regional startup ecosystem. Whether you are exploring a new idea sketched on the back of a napkin or leading a more established, growth-stage company, Coalition members can help connect you with the programs, funding opportunities, mentors, and resources best suited to your needs. No matter where you are in your entrepreneurial journey, any Coalition organization can help point you in the right direction. Coalition Members and Leadership Coalition members include the UNCW Center for Innovation and Entrepreneurship (UNCW CIE), AARP, Brunswick Community College Small Business Center, Cape Fear Community College Small Business Center, Cape Fear Region SCORE, Genesis Block Foundation, Network for Entrepreneurs in Wilmington (NEW), Small Business & Technology Development Center (SBTDC), Greater Wilmington Chamber of Commerce, YWCA Living the Dream Center for Entrepreneurship, Carolina Community Impact Fund (CCI Fund), Partner Community Capital, 717mkt Office Collaborative, NC Biotech, and Institute NC. In May 2026, the Coalition held its leadership elections, resulting in the selection of a new executive team. The following officers were elected to serve two-year terms: Chair: Lydia Thomas, UNCW CIE Vice Chair: Diane Lantz, CCI Fund Secretary: Aariene Hansley, Genesis Block Foundation Treasurer: Gloria Monroe, SBTDC Vision for the Wilmington Small Business Coalition In 2026, the Wilmington Small Business Coalition continues its work as a collaborative network of organizations. By connecting programs, expertise, and services across partner organizations, entrepreneurs can more easily find the right support at the right time. Rather than operating in silos, the Coalition aims to function as a unified, cohesive system of support for small businesses and entrepreneurs, ensuring that resources and expertise across partner organizations are visible and accessible. Through stronger collaboration and shared pathways, entrepreneurs can move more seamlessly from idea to startup to growth. Looking to dive into the Wilmington entrepreneurial ecosystem? Connect with any of the Coalition partners to get started! Connect with CIE To learn more about CIE and our services, programs, and events, join the CIE newsletter. You can also follow us on social media: Instagram, Facebook, LinkedIn, TikTok, or YouTube. CIE’s website is uncw.edu/cie. Heather McWhorter is the director of the UNCW Center for Innovation and Entrepreneurship (CIE). CIE supports innovation-forward start-ups and helps to build a vibrant innovation economy for all in southeast NC.
Post From Community: ThriveOn King Small Business Loan Program returns for fourth round
The Greater Milwaukee Foundation is mobilizing another round of affordable loans to Milwaukee neighborhoods, with preference for disadvantaged businesses facing economic challenges due to rising costs and limited access to capital.
Portfolio manager says Amex is en route to a huge chunk of business from travelers
Advisors Capital senior portfolio manager Gus Scacco discusses the Dow’s record close and some under the radar stocks on ‘The Claman Countdown.’
South Fulton leaders hopeful new investment will address crucial healthcare gap on Atlanta's south side
For decades, residents and officials alike have raised the issue regarding limited access to hospitals and specialty care in South Fulton. Now, county leaders and health officials are earmarking funds to address the situation.
Politics: High Cost Of Healthcare And The Political Fallout
Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Politics: High Cost Of Healthcare And The Political Fallout
Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Mayor Mamdani, NYC Health + Hospitals break ground on $255M River Commons, bringing 328 affordable affordable homes to the South Bronx
The city has broken ground on River Commons, a mixed-use development in Morrisania that will bring 328 affordable and supportive apartments, an expanded
NYC Health + Hospitals/Metropolitan and MetroPlusHealth Support New Mother of Triplets
New York, NY – NYC Health + Hospitals/Metropolitan, in partnership with MetroPlusHealth, today shared the story of Doris A. Lucio Lucio, an immigrant
Lionel Richie's ex-wife shares update on singer's condition after hospitalization
Lionel Richie's ex-wife, Brenda Harvey Richie, shared news on her former husband's health after a medical incident led to a concert stoppage and hospitalization.
Tom Kean Finally Reveals Cause of Absence from D.C.
The New Jersey representative, who has been absent from D.C. since March, revealed in a floor speech that he was hospitalized for depression.
Iowa Business Council projects positive six-month economic outlook
The Iowa Business Council has released its second-quarter Economic Outlook Survey for 2026, showing member expectations for sales, capital spending and employment remain positive for the next six months despite a slight overall decline from the previous quarter. The survey’s overall economic outlook index sits at 64.81 points for the second quarter, a decrease of […]
Maine high court to hear appeal ballot initiative case
Oral arguments are set for 10 a.m. Wednesday at the Capital Judicial Center in Augusta.
Premier Lacrosse League lands $100 million to chase Olympic moment
The funding comes at a crucial period of preparation for PLL, as it looks to capitalize on lacrosse being a part of the 2028 Summer Olympics.
Venezuela health system strained after earthquakes, WHO says
Venezuela's healthcare system is under significant strain, the World Health Organization said on Tuesday, with some hospitals damaged and others missing staff after deadly twin earthquakes last week.
Venezuela Health System Strained After Earthquakes, WHO Says
By Emma Farge GENEVA, June 30 (Reuters) - Venezuela's healthcare system is under significant strain, the World Health Organization said on Tuesday, with some hospitals damaged and others missing staff after deadly twin earthquakes last week. More than 1,700 people have been killed and 5,000 ...
AI cuts hospital system's MRI wait times by more than 50%
The health network, which operates 37 hospitals in California, drastically reduced scheduling delays after integrating an FDA-cleared algorithm designed to speed up imaging acquisition times.
Rafael Nadal talks tennis prize money, his hotels, and what sports taught him about business
Rafael Nadal opened his fourth Zel hotel as he expands into hospitality, education and sports after retiring from tennis.
Developer addresses community concerns around Franklin youth sports complex project
The project, proposed by developer BLVD Capital, would transform Brownland Farm, a 233-acre property on Hillsboro Road just outside downtown Franklin, into “The Banks at Brownland.”
Yale New Haven Health System CEO steps down
Christopher O’Connor, chief executive of Yale New Haven Health System, is stepping down from his role, according to an announcement Monday.
CT health system reveals top CEO stepping down. Nationwide search to be done for replacement.
The CEO of Yale New Haven Health System is stepping down after 14 years in the post, according to the health system. CEO Christopher O’Connor joined YNHHS “after helping lead the Health System’s acquisition of the Hospital of Saint…
AI is rewriting the political competitive landscape
Artificial intelligence is rapidly becoming a central infrastructure layer in political campaigns, reshaping how elections are financed, contested and influenced, The New York Times reports. Campaigns and affiliated political groups are increasingly investing in AI-driven tools for voter targeting, message optimization and large-scale content generation, turning modern elections into capital-intensive, technology-enabled competition. This shift is […]
The most underrated business discipline is hospitality
How a hotel candle reminds this CEO that AI is important, but so is being human in the business environment.
5 takeaways from STAT’s investigation into microhospital operator Nutex Health
Read the takeaways from STAT's investigation into Nutex, which used the No Surprises Act to fuel a stunning financial turnaround.
Unredacted comments from California hospital lawsuits show stunning admissions and a 'forced' McKinsey collaboration
Who controls the Medicaid market, GLP-1 usage and pizza household costs, and more from Health Care Inc.
'They’re like my sisters now': Boutique comforts women post-surgery
While hospitals can feel very clinical, there's a shop that offers products for women post-surgery with kind, friendly faces to provide support.
About 3 million people have dropped Obamacare health coverage after subsidies expire and costs rise
The Department of Health and Human Services suggests the 13% drop is due to a federal crackdown on fraudulent enrollmentut, but health analysts believe it's more likely related to the Jan. 1 expiration of federal subsidies.
Few details known on Mitch McConnell’s health 2 weeks after hospitalization
Two weeks ago, Kentucky Sen. Mitch McConnell was admitted to the hospital. Few details about his condition are publicly known.
How six venture capital giants are reshaping startup financing
The venture capital landscape is becoming increasingly concentrated, with six megafirms— Andreessen Horowitz, Sequoia Capital, Thrive Capital, Lightspeed Venture Partners, Founders Fund and General Catalyst—now raising more capital than all other U.S. venture firms combined over the past two years, Inc. reports. Their growth has been fueled by the enormous capital requirements of AI startups, […]
DMC Sinai-Grace holds 2nd annual health fair with free screenings, food, entertainment
DMC Sinai-Grace Hospital is taking patient care beyond the hospital walls and into the heart of the Detroit community.
DMC Sinai-Grace holds 2nd annual health fair with free screenings, food, entertainment
DMC Sinai-Grace Hospital is taking patient care beyond the hospital walls and into the heart of the Detroit community.
Jackson fallout, Tuberville fight shape Alabama politics
Jackson Hospital, medical cannabis, Tuberville’s residency fight, tax reform and family farms reveal Alabama politics under pressure again this week.
4 Sectors Attracting Seed Funding in Digital Entertainment
Digital entertainment is navigating a paradox. Overall venture capital flowing into gaming dropped sharply through 2025 and into 2026, yet seed-stage deal activity has remained surprisingly resilient across a handful of focused verticals
CVC Capital Partners to Buy Ingredients Business Irca From Advent
Irca creates more than 7,000 products and serves customers in more than 100 countries and CVC said it would support the next phase of the company’s growth.
Central College to offer data science major this fall
Central College will offer a new data science major starting this fall, bringing together STEM, social sciences and humanities teaching.
Ahead of the MLB trade deadline, here’s where the Guardians stand
The Guardians are among the best teams in a weak American League. This is the time for them to capitalize on their situation.
Medicare pushes end-of-life discussions in hospitals
Questions about living wills and other "advanced directives" are often skipped — or become a box-check in the admissions process.
Scottsdale Golf to host fan entertainment and retail hub in Birkdale during Open Week
Southport & Birkdale Sports Club to become free entry experience, combining golf, retail, entertainment and hospitality.
Rural Fosston moves forward in its quest to relinquish control of local hospital from Essentia Health
A northwestern Minnesota community is seeking to regain local control of its hospital, arguing Essentia Health has failed to meet local health care needs. A recent court ruling allows Fosston to take its case to arbitration.
PPDS Brings 'Limitless' TV Entertainment To Historic 5 Star Bellevue Syrene Hotel With Philips MediaSuite
PPDS, the exclusive global provider of Philips Professional Displays, has announced that its Philips MediaSuite TV range has been chosen to deliver seamless access to a virtually limitless world of | Delivering modern luxuries to the 18th century hotel in Sorrento, Philips MediaSuite TVs with cast built in are now bringing seamless access to millions of movies, TV shows, games, and streaming apps to guests at one of Italy's most prestigious and exquisite hospitality destinations.
South Korean tech giants to build a $518 billion chipmaking hub to serve soaring AI demand
South Korean tech giants Samsung Electronics and SK Hynix plan to invest a combined $518 billion in a new computer chip manufacturing hub, capitalizing on surging artificial intelligence-driven demand.
The ERs that can turn patients away
The hospital operator Nutex enriched itself by exploiting loopholes in laws meant to protect patients, STAT found.
Martin County residents keep pressing state officials for funding to reopen hospital
ECU Health has proposed converting Martin General into a Rural Emergency Hospital under a federal designation.
Al-Diriyah join race for Soule who remains unconvinced
Matias Soulé’s future seems far from Rome. Regardless of what happens by tomorrow, the Argentine winger is expected to leave the capital, as the Giallorossi have clear ideas about who will play in ...
John Oliver scores his dream job: A soap opera gig on 'General Hospital'
The host of HBO's "Last Week Tonight" will realize one of his big wishes in July with a guest spot on the ABC soap opera "General Hospital."
Suns trade Grayson Allen, Royce O'Neale for Miles Bridges
The Suns have agreed to trade two key rotation players and a 2033 first-round pick for Hornets forward Miles Bridges and future draft capital.
Rep. Jahana Hayes released from hospital after health scare
Representative Jahana Hayes has been released from the hospital after a health scare last week. In a video posted to Facebook on Sunday, she said she was leaving St. Mary’s Hospital where she was admitted for the last two days. “On Friday, I felt like I was dizzy while shopping, I was out getting phones at the mall and felt…
Q&A: Why humanitarian aid is crucial to stopping the Ebola outbreak
Health officials say the Ebola response cannot succeed without addressing the humanitarian crisis.
3 Traps Health Systems Fall Into When Trying to Improve Their Culture
Cultivating a positive culture is a priority for hospital leaders, but many are making avoidable mistakes. Myra Gregorian, Seattle Children's chief people and transformation officer, outlined some of these common blunders — such as not involving frontline staff in decision making and assuming that simple communication methods are sufficient.
Family visited Water Park Capital of the World; wouldn't do it again
Wisconsin Dells, "Water Park Capital of the World" had many family-friendly activities for our multigenerational travel group, but the cons added up.
Juventus hold exploratory talks for Soule’s return
Matias Soulé is among the candidates to leave Roma in the coming days and be sacrificed on the altar of capital gains. The Argentine winger isn’t pushing to leave; on the contrary, he’s stalling....
38,599 Shares in Caesars Entertainment, Inc. $CZR Bought by 1492 Capital Management LLC
1492 Capital Management LLC purchased a new stake in shares of Caesars Entertainment, Inc. (NASDAQ:CZR - Free Report) during the first quarter, according to the company in its most recent disclosure with the Securities & Exchange Commission. The institutional investor purchased 38,599 shares o
Valleywise Health acquires system to better treat premature and critically ill infants
Valleywise Health has a new system to better treat premature and critically ill infants, becoming the first Arizona hospital to implement it.
Ranked: America’s Best-Selling Albums Ever
Michael Jackson may be the king of pop, but in the U.S. he's been outsold by a rock band from Los Angeles.
Ryman Hospitality Addresses Reports About Opry Entertainment Group
Ryman Hospitality Properties addressed recent media reports regarding its Opry Entertainment Group business.
Trump admin rule puts reproductive health care for 160K Pa. patients at risk, lawsuit says
A lawsuit says family planning and health organizations in Pennsylvania could face federal funding delays or denials due to a new Trump administration policy.
140 Kauai Coffee jobs saved through new land lease agreement
The lease agreement between Kauai Coffee’s parent company, Massimo Zanetti Beverage Group, and landowner Brue Baukol Capital Partners was finalized after nearly two years of negotiations
AI-assisted colonoscopy enhances polyp detection at UT Health San Antonio Multispecialty and Research Hospital
Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu Content provided by Kristen Zapata SAN ANTONIO, June 29, 2026 – A routine colonoscopy may last less than an hour. But what happens during that procedure can change, or even save, a life years before cancer ever has a chance to develop. Physicians at The University of Texas at San […]
$13 million in federal funding to be distributed across West Michigan clinics
More than $13 million in federal funding will be distributed across West Michigan hospital and clinic systems for research projects and healthcare infrastructure.
Civility advocates look for ways to restore 'Iowa Nice' to campaigns, public discourse
A group of former and current officeholders are looking to encourage civility by encouraging civic participation and civil interactions.
The Venezuela Earthquakes Hit a Health System Already in Crisis
Firefighters are using cellphone lights because of a flashlight shortage, and an overwhelmed hospital in the disaster zone is operating without running water, one doctor said.
Ryman Hospitality Addresses Possible Sale of Opry Entertainment Group
Corporation officials say they are exploring the possible sale of a 70 percent stake in the entertainment entity, but there are no agreements in place and ‘no assurances any transaction will occur.’
Summer Science Program
Explore information about the Summer Science Program at Arkansas Children's Hospital, a career readiness program for college students, including eligibility and how to apply.
NYC Health + Hospitals/Queens NICU Awarded Gold Beacon Award for Excellence
The Neonatal Intensive Care Unit (NICU) at NYC Health + Hospitals/Queens has been honored with the prestigious Gold Beacon Award for Excellence from the
Music Legend Axes Shows After Onstage Health Scare
Lionel Richie was hospitalized on the opening night of his tour with Earth, Wind & Fire after feeling dizzy on-stage.
Lionel Richie is 'heartbroken' to postpones concerts after reported hospitalization
Lionel Richie is postponing two shows after cutting his St. Paul, Minn., concert short and a reported hospitalization.
Chairman Guthrie, Health Vice Chair Harshbarger, Congresswoman Miller-Meeks Lead Site Visit to Iowa Hospitals to Highlight Benefits of the Rural Health Transformation Program
The Committee on Energy and Commerce is the oldest standing legislative committee in the U.S. House of Representatives and is vested with the broadest jurisdiction of any congressional authorizing committee.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Big Ten women’s sports are having a moment. What is the league doing to capitalize?
In the two years since Caitlin Clark left for the WNBA, the Big Ten has worked to keep its momentum.
How Outward Intelligence founders bootstrapped to seven-figure revenue
Three friends with résumés spanning Google, Palantir, and Harris Poll skipped venture capital and bootstrapped their startup instead.
Gay Street businesses cope with Capital Line construction
The Capital Line is meant to be transformative for Downtown. But right now it's presenting challenges for businesses.
Ohio Black-owned businesses, payroll has increased, bringing bigger share of economy to group
According to analysis of national census data, black-owned businesses in Ohio continue to increase payroll, and drive jobs and income in the state.
Hall of Fame GM Expresses Concerns About Extending Vita Vea
As a lucrative "hold-in" intensifies, Bill Polian warns that committing massive capital to an aging nose tackle could backfire for a Tampa Bay roster already in transition.
California unions, hospitals strike deal — but billionaire tax heads to ballot
Two healthcare ballot measures are gone. One very contentious wealth tax isn't.
The Week in Business: D'Amico Hospitality's Next Chapter
This week’s top stories from Twin Cities Business.
Granger family pledges largest gift in history of UM-Health Sparrow
The Granger family has pledged the largest gift in University of Michigan Health-Sparrow history for a new behavioral health hospital.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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