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Baltimore Ravens vs. Cleveland Bengals Week 6 game discussion
Join the discussion about the Ravens’ Week 7 matchup with the Bengals!
Game Time Thread: Juventus vs. Lecce
MATCH INFO When: Sunday, Oct. 25, 2026. Where: Stadio Via del Mare, Lecce, Italy. Official kickoff time: 6 p.m. local time in Italy and across Europe, 8 p.m. in the United Kingdom, 1 p.m. Eastern time, 12 p.m. Central time, 10 a.m. Pacific time. (Please note that the fall time change in Italy goes into effect on Sunday, […]
Cost of employer-sponsored health insurance rises again, survey finds
WASHINGTON — The cost of employer-sponsored health insurance increased again this year, as did the deductibles many people must pay before their plans begin covering most health care expenses, according
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Their friend died of cervical cancer in 2020. Now, they advocate for women’s health in N.S.
Following the death of their close friend from cervical cancer in 2020, two women in Nova Scotia were left wondering how things might have been different had she been diagnosed earlier. Six years later, they have raised over $4 million to improve technology and infrastructure for women's health.
Seattle Mariners Rumors: Zach Neto Gaining Traction as Possible Target
The M's certainly have a need for what Neto can provide.
Stateliner Pride on Display: Phillipsburg Band and Alumni Unite at Halftime
Phillipsburg’s Stateliner band and alumni joined for a halftime performance celebrating school tradition, pride and community at Friday’s football game.
GO Health asks families to be lead-aware
BATAVIA — Area health departments are encouraging families to get the facts and get their children and homes tested for National Lead Poisoning Prevention Week.
AI-generated video heats up suburban Texas political clash
Fort Bend County has seen plenty of controversy at its highest levels.
Evaluating DJ Herz After Bouncing Back from Injury with Nationals
After making his first MLB appearance in nearly two years, what should the Washington Nationals expect from DJ Herz in his third season with the organization?
What Chelsea Did Wrong vs Tottenham
After a stellar run following the international break, things came crashing down for Chelsea as they lost 2-0 to Tottenham Hotspur at the weekend. This marked an extremely rare defeat at Stamford Bridge to the Lilywhites, a crack in a strong record of home wins that has left fans reeling. In this, we will be …
Scientists Find Chronic Back Pain Activates a Brain Network Linked to Personal Identity
A new UC San Diego brain imaging study involving 114 adults suggests that chronic back pain flare-ups affect brain networks involved in self-reflection and personal memories. The findings may help exp...
Aaron Rodgers passes Peyton Manning on all-time touchdowns list
Aaron Rodgers surpasses Peyton Manning in all-time touchdown passes.
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign
Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.
World's Fastest Lawnmower Company Is Officially Going Out Of Business
Dixie Chopper made the world's raddest lawnmowers for almost half a century, but its story is now coming to an end.
Grading Iowa Football's Loss To Minnesota
This may have been Iowa's worst quarterback performance since the dreadful 2023 season.
Mavericks 'Very, Very Confident' in Rookie PG Behind Kyrie Irving
Spanish sensation Sergio de Larrea shined with 21 points against San Antonio, proving he can anchor the rotation while Dallas carefully manages Kyrie Irving’s heavy workload.
10 Thoughts From Watching Others Sweat It Out
Back during the very lean years of the Ray Goff era in Athens, a certain revered columnist for the Macon Telegraph joked in a weekly prediction column that Georgia would lose to “Open” during its upcoming bye week. Thankfully, those years have passed by, and the outlook for Georgia during open weeks for what is […]
NFL Trade Deadline Could Dramatically Change The AFC South Landscape
With top stars from the Titans, Colts, and Jaguars hitting the trade block, Houston’s rivals could strip their rosters of veteran talent to fuel a mid-season rebuild.
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say
A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…
Michigan's Jason Beck promised change, but numbers tell another story
Michigan football vowed to fix its perimeter run game or stop it, but the team continues to struggle on the edge.
Opinion - How Trump learned to stop worrying and love space science
He recognizes a cool thing when he sees it.
Evan Mobley on Jarrett Allen: “The team loves it. …
Evan Mobley on Jarrett Allen: “The team loves it. …
Investment driving growth at NWS Crane
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Crystal Palace v Chelsea
Follow live text commentary, score updates and match stats from Crystal Palace vs Chelsea in the Women's Super League
Clemson HC Dabo Swinney Waving White Flag on Season
Following a humbling loss to Virginia Tech, Dabo Swinney is recalibrating expectations as the Tigers abandon playoff dreams and fight to salvage a disappointing, sub-par season.
Liverpool host Brighton; Man Utd take on Bournemouth in PL
2026-10-25T13:33:41ZA rundown of today's games...2pm kick-offs:Liverpool vs BrightonManchester United vs BournemouthHull City vs BrentfordCrystal Palace vs Newcastle4:30pm kick-off:Sunderland vs Leeds...
Health board still paying for research despite criticism over patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
Health board still paying for research with 'unclear' patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
Ranking Ohio State’s remaining games from easiest to hardest
With Julian Sayin out indefinitely, Ohio State’s final five games will define their playoff hopes. Here’s how those opponents rank, from easiest to toughest
NFL Week 7 expert picks, score predictions: Packers at Lions
Green Bay Packers vs. Detroit Lions NFL Week 7 expert picks from the Pride of Detroit staff.
Saints vs. Steelers in Paris: Week 7 game chat
The Saints face the Steelers in this Week 7 matchup. Join us here for the game!
r/opensource just banned AI, non-English speakers and more
The opensource subreddit’s new rules against AI have sparked a revolt.
Week 7 Early Games Open Thread
The only games I’m really keyed in on are the Steelers and Texans both losing to the NFC team and then decided which team between the Bengals and Ravens are the bigger threat to Denver’s future playoff seeding arrangement. Here are the games we have to watch today before the Denver Broncos take on the […]
NFL Week 7 Game Discussion and Open Thread
Talk about all the Week 7 NFL games with us here!
Taylor Dayne Trades L.A. for Coastal Sanctuary After Health Battle
The pop icon has traded the hustle of Los Angeles for a new life in Santa Barbara after recovering from a harrowing battle with colon cancer.
Colts vs. Vikings
Here is how the ColtsRoundtable staff sees the Week 7 matchup between the Indianapolis Colts and Minnesota Vikings unfolding.
Indiana football should be better. It also could be worse
On one hand, Indiana hasn’t played its best football in weeks. On the other, neither has anyone else, really.
Open Thread, Sunday, October 25: How we doing today, folks?
Your daily source for off topic chatter with the MMA Mania faithful.
Iowa Football Was Never Truly A CFP-Caliber Team. The Loss To Minnesota Proved It
The Hawkeyes had plenty of momentum after the Washington game, but there's just too much inconsistency right now. Everything fell apart against Minnesota.
Arkansas basketball displays true toughness against Gonzaga
The big story of the win over Gonzaga: These Hogs play defense
Will the Brewers lose again this year?
Milwaukee is cooking, y’all. After winning 103 regular season games, they blew through the Padres in the Division Series, swept the Dodgers in 4 games in the Championship Series and currently have a 2-0 lead in the World Series. They’re 5-1 in one-run games, so they’re not exactly blowing teams out. But with their bullpen […]
Adolph Reed on What It Will Take to Defeat Trumpism
Donald Trump’s popularity may be waning, but the political-economic conditions that gave rise to Trumpism remain, Adolph Reed argues. To defeat the Right, the Left needs to rebuild durable working-cla...
Clay Walker Christmas coming to NPAC Nov. 29
GREENEVILLE — Rumor has it … it’s shaping up to be A Clay Walker Family Christmas.
At Issue: Oct. 25 focuses on political advertisements, Rep. John McGuire candidate profile
In less than two weeks, the votes will be in and you will know who will represent your hometown in Congress. But until then, the political advertisements will target you on every device and platform.
Pair of CBs Lead Steelers Inactives vs. Saints
Terell Smith will have to wait to make his Pittsburgh Steelers debut for at least another week. The fourth-year cornerback, […]
Mark Allen 'completely overwhelmed' after opening up about mental health
The snooker player has given fresh hope that he may return to competition
2026 Vanderbilt Football Mailbag #9: Call For Submissions
Post VANDERBILT Football and/or SEC Football questions in the comments here. It’s becoming more and more obvious we’re highly unlikely to win another game this season. Our defensive calls make no sense, we’ve got an uber-talented but uber-raw QB learning on the jerb, and Barton Simmons’ decision to staff our O-Line exclusively with matadors has […]
After win over Ole Miss, Texas QB Arch Manning says that he 'kind of likes being disregarded'
Iain Armitage says “Young Sheldon” cast drove each other ‘crazy’ while shooting season 3 opening credits
The ensemble would ‘drive each other nuts.’
Iain Armitage says “Young Sheldon” cast drove each other ‘crazy’ while shooting season 3 opening credits
The ensemble would ‘drive each other nuts.’
Detroit Lions updated depth chart: Week 7 vs. Packers
An updated look at the 2026 Detroit Lions’ depth chart ahead of their Week 7 game vs. the Green Bay Packers.
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day | Newsradio 1140 WRVA
AI in policing risks deepening discrimination, research warns
AI tools learn from biased records and may deepen discrimination against minorities without oversight, researchers say.
Political analysis favors Mendoza over Ciscomani
The Cook Political Report has switched its assessment of the congressional race for the House seat from a “toss-up” ranking to “Leans Democratic.”
Week 7 inactives for Saints
New Orleans declares seven players inactive versus Pittsburgh
What analysts are watching in the Texas Senate race, CBS News political experts weigh in
The top 25 classic golf courses in Canada, ranked
We rank the best courses built in Canada before 1960.
Utah Jazz Must Let Darryn Peterson Feel the Pressure
Shielding Utah’s prized rookie from high-stakes moments only stunts his growth. To secure their future, the Jazz must force Darryn Peterson to embrace the game-deciding pressure now.
Texas A&M Defense Folds Again As Alabama Exposes Aggies In Late Collapse
Texas A&M's defense surrendered 311 passing yards and two fourth-quarter touchdowns in a 31-20 loss to Alabama, raising more questions about Mike Elko's Aggies.
Scientists reveal the hidden danger of missing blood pressure medication
Missing blood pressure medication could mean losing much of its protection against heart attacks and strokes, according to an analysis of more than 91,000 people. Patients who consistently took their medication experienced an 11% reduction in major cardiovascular events, while those who missed too many doses saw little or no measurable benefit.
Scientists Trapped an Antimatter Particle for Months to Study Its Secrets
These elusive and reactive particles have been challenging to hold on to and even more challenging to study, but a new method paves the way for tests on the differences between matter and antimatter.
This Week in Purple: Around The World (Series)
Colorado Rockies news and links for Sunday, October 25th, 2026
Patriots rooting guide for NFL Week 7
Rooting information, kickoff times, TV schedule and more for NFL Week 7.
Giants at Texans: How to watch, TV schedule, and more
Wanna watch a Texans game? We can help you with that.
Memorial Health dietitian highlights importance of blood sugar management
Zeff encourages people to schedule regular medical appointments and get their blood sugar tested, particularly those with a family history of diabetes.
Game status update for Browns CB Denzel Ward against Titans
Cleveland gets an update on the status of their top cornerback.
Browns Week 7 fantasy start-sit: Boston, Judkins, Fannin, Concepcion
Tennessee has allowed the 10th-most half-PPR points to receivers, while Dylan Sampson’s return from injured reserve threatens Quinshon Judkins’ receiving work.
'Multwoh' becomes highest-grossing film of CinePanalo
'Multwoh,' a queer romance-horror film, has become the highest-grossing film to emerge from the Puregold CinePanalo Film Festival, the film’s team said Sunday.
Real Madrid rocked by Thibaut Courtois INJURY BLOW just hours before El Clasico showdown with Barcelona
Real Madrid have suffered a major setback ahead of their crucial Clasico showdown against Barcelona after goalkeeper Thibaut Courtois was ruled out through illness. His late withdrawal forces the club to rely on deputy Andriy Lunin for the vital Liga fixture at Camp Nou.
NFL Week 7 expert picks, predictions: Moneyline, against the spread
A look at our expert picks for Week 7 of the 2026 NFL season.
Sunday Night Football: How to watch the Kansas City Chiefs vs. Seattle Seahawks game tonight
WSL: Crystal Palace host Chelsea in first of five games
Follow live coverage of Crystal Palace host Chelsea in the first of five Women's Super League games on Sunday.
Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links
Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links New York City, USA, Oct. 25, 2026 (GLOBE NEWSWIRE) -- Founded by Rollo Unden and Oliver Fish, Unfair Links builds local backlinks matched to a business's Google Business Profile, country and language, and is now taking sign-ups for its beta waitlist. Unfair Links, a new link building
'Leaky gut' isn’t a medical diagnosis. Here’s what it really means
Here’s what can happen when your intestinal lining becomes inflamed or injured.
NFL.com Experts Rolling With Broncos In Week 7
Fresh off a gritty win, Denver faces an injury-riddled Arizona squad as analysts eye a potential breakout performance for Bo Nix against the struggling Cardi...
New York Giants' Never-Ending Nightmare Might Get Even Worse
Things just keep getting worse for the New York Giants.
Phillies news: Alec Bohm, Justin Crawford, Cal Ripken, Jr.
Why do I like one and not the other?
Turnovers continue to plague the Cavs in the fourth quarter
“There’s no excuses, but we are working on it,”
Selected Shots Sunday: Women’s Sports & Margo Mania!
This week’s photos feature soccer, volleyball and softball— EVERYONE WATCHES WOMEN’S SPORTS
How to Watch: Arizona Cardinals vs. Denver Broncos
Everything you need to know about the Arizona Cardinals game against the Denver Broncos.
How to watch Lions vs. Packers: TV, streaming, radio, more
TV, online streaming, announcer, and kickoff time information for Detroit Lions vs. Green Bay Packers.
Today on Pinstripe Alley
Heading into the final week with baseball in 2026.
What we learned about our politics in the 2026 Texas elections
From the governor's race to local offices, the culture wars gave way to public education and property taxes.
BREAKING: Courtois out against Barcelona
Real Madrid have announced that goalkeeper Thibaut Courtois will not play against FC Barcelona tonight. Per Realmadrid.comCourtois is a last-minute drop due to a flu process for tonight’s match between Real Madrid and Barcelona, corresponding to the tenth round of the League. Illia Voloshyn enters the squad list in his place. This is devastating news […]
Colts Make Roster Moves Ahead of Sunday's Matchup
The Indianapolis Colts made roster moves ahead of Sunday's matchup against the Minnesota Vikings.
YouTube Gold: Highlights From Louisville’s Trip To Kansas
Kansas lost Wednesday, but the Jayhawks are not exactly pushovers
‘Talking to every single person matters’: ‘prairie populists’ canvass the rural US heartland to win in midterms
Democratic and independent candidates stump the US midwest and prairie states, hoping to win over Republican strongholds
When a teen posts a selfie, how much filter is 'too much' filter?
The recent Meta settlement includes a clause banning "cosmetic procedure filters" for teens. But defining what constitutes an extreme makeover isn't easy.
UCLA’s perfect start has one glaring flaw it must fix soon
Bob Chesney has made UCLA the second-half darlings of college football, but the Bruins must address their slow starts if they hope to reach the playoff.
Islanders Gameday News: Starting in Dallas; Hellebuyck moves next door
The Islanders have touched down in Dallas for a Sunday night encounter, where Pete DeBoer will be the story as he faces his most recent former team. The Stars are in their 1980s Capitals era (or more generously, 1980s Flyers), perennially fielding really good teams but finding different reasons and divine interventions to prevent their […]
The Political Upstarts That May Decide Israel’s Election
The upcoming Israeli election may be decided by two small parties that didn’t even exist a few months ago.