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Miley — Bass Persuades: Live at the Hollywood Bowl: Where and when to buy tickets to see Miley Cyrus
Here's how to get tickets to see Miley Cyrus in concert.
State health officials highlight importance of newborn screenings
State health officials are reminding new and expecting parents that a simple test can flag hidden health problems in babies before they become serious.
How to watch the 2026 Emmys: Start time, where to stream, full nominee list and more
Are you ready for the 78th Primetime Emmy Awards?
'Practical Magic 2' review: Sequel honors the original by being a similarly dopey mess
The original "Practical Magic" wasn't a great film — but its fans might appreciate this similarly muddled sequel more than our film critic did.
Scientists find a huge 10-sided pattern in the clouds over Saturn's south pole
Scientists have discovered an enormous 10-sided wave pattern in the icy ammonia clouds over Saturn's south pole
Live Results: Rhode Island midterm primaries
Rhode Island Gov. Dan McKee faces a tough Democratic primary challenge Wednesday in his bid for a second full term.
Live Results: New Hampshire midterm primaries
The race to replace retiring three-term Democratic Sen. Jeanne Shaheen is one of a handful across the country that could determine control of the U.S. Senate for the second half of President Donald Trump’s final term.
North Dakota Today - North Dakota Small Business Development Center
recurring recording of North Dakota Today on KVLY
Moment of Science: Abundant oxygen not enough to explain massive ancient insects, new study suggests
Unlocking answers about giant ancient insects! Here's why an abundance of oxygen 300 million years ago may not explain why some animals got so gigantic after all.
Never watched 'Widow's Bay'? How the creepy comedy became an Emmy favorite.
Matthew Rhys stars in the Apple TV hit that took nearly 20 years to make.
Hidden camera found inside bathroom leads to arrest of Volusia County man, deputies say
He faces 10 counts of digital voyeurism and 11 counts of video voyeurism of a child.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
New Hampshire voters pick midterm nominees as Sen. Shaheen's exit sparks scramble for key seats
New Hampshire primary voters are choosing candidates for Congress, governor and the 424-seat state Legislature on Tuesday, and incumbents aren’t the only familiar names on the ballot.
Kamin Science Center using multi-day closure to refresh exhibits on all floors
Officials say the museum is using the mid-week closure to refresh and maintain exhibits and visitor experience across all five floors.
The Latest: Canada strikes back with tariffs on about $20 billion worth of US goods
Canada struck back at U.S. President Donald Trump on Tuesday with tariffs on about $20 billion worth of U.S. goods, in response to his latest round of tariffs on Canada.
Apple’s new CEO John Ternus expected to debut foldable iPhone at event Wednesday
Apple will kick off a new era on Wednesday when CEO John Ternus takes the stage for the first time for the company’s annual iPhone launch event.
Honda brings Mamadou Diallo back to lead its U.S. auto business
Honda brings Mamadou Diallo back to lead its U.S. auto business, giving dealers a familiar executive with deep Honda and Acura experience.
Ashley St. Clair and Alex Gibney on AI and the dangers of Elon Musk
A new documentary about Elon Musk uses an AI avatar to simulate an interview with him, using real quotes.
Parakeet Health lands major AI partnership with national dermatology group Qualderm
Parakeet Health landed a major partnership with Qualderm, one of the nation's largest dermatology organizations, as the company looks to apply agentic artificial intelligence to a growing specialty | Parakeet Health landed a major partnership with Qualderm, one of the nation's largest dermatology organizations, as the company looks to apply agentic artificial intelligence to a growing specialty care access problem.
Immune Cells’ Role as Quality Control Boosts Tissue Health
Macrophages maintain the function of certain organs by eliminating waste products. Studying this process could lead to clues for healthier aging.
Joliet Chamber: The value of being connected and why business relationships still matter
With busy schedules and countless demands competing for their attention, simply putting a networking event on the calendar isn’t always enough. People want to know that their time will be well spent.
Rosanne Cash postpones shows over health emergency
Rosanne Cash postpones shows due to health. Discover her musical journey and Johnny Cash's influence.
Rosanne Cash postpones shows over health emergency
Rosanne Cash postpones shows due to health. Discover her musical journey and Johnny Cash's influence.
Rosanne Cash postpones shows over health emergency
Rosanne Cash postpones shows due to health. Discover her musical journey and Johnny Cash's influence.
Ancient Roman fresco and mosaic featuring maritime city unveiled at newly restored Baths of Trajan
Authorities in Rome have unveiled what is believed to be the largest fresco and mosaic complex of ancient Rome.
Accenture and Google Cloud Deepen Partnership with Formation of New Accenture Gemini Enterprise Business Group
Accenture and Google Cloud today launched the Accenture Gemini Enterprise Business Group, a global group designed to help clients scale Gemini Enterprise outcomes in the agentic AI era.
Tyson Cuts Outlook as U.S. Cattle Shortage Hammers Beef Business
Photo credit piter2121 - stock.adobe.comTyson Foods lowered its fiscal 2026 profit and sales forecasts Thursday as the historically tight U.S. cattle supply continues to pressure meatpackers. The company now expects adjusted operating income of $1.85 billion to
BOOK REVIEW: 'Charlie St. Cloud'
In the village of Marblehead, Mass., 28-year-old Charlie St. Cloud has spent his adult years taking care of the lawns and monuments of the cemetery where his younger brother, Sam,
Alabama Department of Mental Health highlights life-saving resources for Prevention, Recovery Months
This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.
Alabama Department of Mental Health highlights life-saving resources for Prevention, Recovery Months
This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.
Alabama Department of Mental Health highlights life-saving resources for Prevention, Recovery Months
This September, the Alabama Department of Mental Health and statewide partners are working to raise awareness, fight stigma, and share life-saving resources.
How to watch the 2026 Emmys: Start time, presenters, full nominee list and more
Are you ready for the 78th Primetime Emmy Awards?
The new tax changes every small business needs to know
Principal Tax Research Analyst at the Tax Institute at H&R Block, Carl Breedlove, breaks down what's new for 2026 filers, from higher reporting thresholds to new forms for crypto and digital asset transactions. If you run a small business, freelance, or trade digital assets, here's what you need to know.
Trump threatens Canadian jetmaker Bombardier, which has an extensive US footprint
U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the United States.
Trump threatens Canadian jetmaker Bombardier, which has an extensive US footprint
U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the United States.
Eureka Springs Police Chief creates unique system for enforcing the rules of the permanent entertainment district trial
KY3's Billie Brightman reports.
'The Pitt' led 2026 Emmy nominations. But another show is ahead after the early awards.
The biggest prizes are still ahead, but shows including "Widow's Bay" and "DTF St. Louis" have already made their mark.
MORNING BUSINESS REPORT: Record number of 401(K) millionaires, colleges facing enrollment cliff
Jane King has these stories and more for your Tuesday Morning Business Report from the New York Stock Exchange.
This creepy 'statue' that looks like a robed figure on Mars gives us the chills. Here's what's really going on | BBC Sky at Night Magazine
The creepy robed statue of a female figure on Mars was spotted by the Spirit rover on the Red Planet in 2007. Here's what it really is.
WATCH | Mobile speech therapy business ‘Speech on the Spot’ helps meet families needs
Stepping inside Speech on the Spot, a mobile therapy business, visitors are greeted by bus walls decorated with stickers of sunshine, clouds and the phrase "Imagination Blooms."
Healthwatch: Survey reveals how social media influences men’s health
A new Cleveland Clinic survey finds that while a majority of men never trust health information shared by influencers, they are still being influenced.
Asian shares and US futures are mixed, while oil prices creep higher
Asian shares and U.S. futures are mixed after U.S. markets were closed for the Labor Day holiday.
What Farage’s oyster etiquette says about his politics
When it comes to fish, Reform is across the mores
Phoenix family says call for mental health help ended in deadly police shooting
A Phoenix family says their call to police for help during their son’s mental health crisis ended with him being shot and killed by officers. Phoenix police say 20-year-old Jonathan Marquez Delgado was armed with a knife and ran toward officers. There are different accounts of what happened Sunday morning.
Phoenix family says call for mental health help ended in deadly police shooting
A Phoenix family says their call to police for help during their son’s mental health crisis ended with him being shot and killed by officers. Phoenix police say 20-year-old Jonathan Marquez Delgado was armed with a knife and ran toward officers. There are different accounts of what happened Sunday morning.
A men's health doctor says many men with low testosterone are getting misdiagnosed — and missing lab tests could be why
Sometimes men are treated for depression when low testosterone is the real cause. A men's health physician explains the signs, the tests, and what to do next.
Americans' satisfaction with schools is at a low point, new Gallup poll shows
A new poll shows that only 32% of Americans are satisfied with the quality of K-12 education in the country
Americans' satisfaction with schools is at a low point, new Gallup poll shows
A new poll shows that only 32% of Americans are satisfied with the quality of K-12 education in the country.
Trump wants voters to pretend he’s on the ballot. The Republican Party is going along for the ride
President Donald Trump may try to channel the role of cowboy as he heads to the first-ever off-year Republican convention in Dallas beginning Wednesday.
The GOP was confident about keeping its Senate majority. Now the fight for control is wide open
Control of the U.S. Senate is up for grabs with less than two months until Election Day.
Tencent Cloud Powers Bookme's Global Business Growth with Scalable Cloud Infrastructure
/PRNewswire/ -- Tencent Cloud, the cloud business of global technology company Tencent, today announced its collaboration with Bookme, which started in...
With Ohio’s governorship up for grabs, a toxic race turns violent
An alleged assailant forced his way Sunday toward Democratic candidate Amy Acton at a county fair, officials and witnesses said. Authorities said he was carrying two pistols and a Taser.
DTU fights to keep union certification before Tuesday deadline
Duval Teachers United needs 498 more members by end of business Tuesday to meet the 60% membership threshold required by Florida Senate Bill 1296 or face a certification election.
US Open: Coco Gauff bests Iva Jovic in straight sets to return to quarterfinals
Gauff held off the surging American teenager to make her first appearance in the US Open quarterfinal since she won the tournament in 2023.
McHenry County Mental Health Board: Conversations that Matter Mental Health Summit is Sept. 11
The public is invited to attend a day of deep connection to move beyond surface-level interaction to engage in transformative communication at the McHenry County Mental Health Board Community Connections Summit on Sept. 11.
AI identifies 800 plant proteins for sustainable food emulsifiers
Scientists at the University of Leeds have developed an AI-driven process capable of rapidly identifying plant proteins with emulsifying properties, potentially replacing synthetic and animal-derived alternatives in food and cosmetic applications.
Man arrested after alleged attack on Amy Acton; candidates across Ohio denounce political violence
Patrick Havas, 38, faces charges after Canfield Fair incident as candidates across Ohio denounce political violence
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Longtime flea market announces closure after 47 years in business
Labor Day marks end of tourist season for local businesses
While crowds filled the Carolina Beach boardwalk for Labor Day, the holiday unofficially marks the end of the coastal tourist season, prompting local business owners to reflect on their summer success.
Labor Day marks end of tourist season for local businesses
While crowds filled the Carolina Beach boardwalk for Labor Day, the holiday unofficially marks the end of the coastal tourist season, prompting local business owners to reflect on their summer success.
2 Dolly Parton films in Upstate theaters as part of benefit screenings
Regal Global Entertainment announced that its celebration of Dolly Parton and her legacy has been extended with showings of two of her films coming to 35 states, including South Carolina.
City of Durango will move almost 30 employees to Axis Health building ahead of City Hall construction
Community Development and Engineering building faces demolition
Jackson County Behavioral Health to host presentations on youth safety, drug trends & digital world
Jackson County Behavioral Health to host presentations on youth safety, drug trends & digital world
CPS report details mental health concerns before Marlene Vidal was charged in children’s deaths
A newly released Child Protective Services fatality report offers new details about concerns involving Marlene Vidal’s mental health and stability in the year before she was charged with killing her two children and setting a car on fire with them inside.
EU seeks to reassure a Trump-rattled Greenland with promise of a new partnership and investment
The European Union is promising Greenland a stronger partnership and hundreds of millions of euros in investment, wanting to reassure Greenland after U.S. President Donald Trump's threats to take control of the island.
Midterm elections head into the home stretch as candidates attend Labor Day events
This year’s campaigns already have been combative, busy and expensive.
NIU STEAM CAFE to explore prairie restoration science
Northern Illinois University will partner with Wild Roots Nature Center to hold a STEAM Cafe for community members to learn about prairie restoration science as part of Wild Roots Nature Center “Nature on Tap Series.”
Every Toilet Flush Can Send a Cloud of Microbes into the Air That Can Reach Your Breathing Zone
The plume can reach breathing height, but the actual infection risk remains uncertain.
ADHA shifts My Health Record to multi-supplier ops as Accenture signs new 3-year contract
ADHA moves My Health Record to a multi-supplier model as Accenture renews for three years. GPT‑6 Astra and HIMSS cyber warnings raise new governance work for CI
A whiplash election year enters its final stretch as Trump holds wild cards
As the final midterm of Donald Trump's presidency rapidly approaches, the landscape is proving especially volatile, with Trump often stirring the tumult.
Extended interview: Vivek Ramaswamy condemns political violence after alleged attack of Amy Acton
An armed Canfield man was arrested Sunday at the Canfield Fair after lunging at Ohio gubernatorial candidate Dr. Amy Acton and injuring multiple people, according to campaign officials and sheriff’s deputies.
Trump keeps heralding an economic boom, but even a solid jobs report is causing problems for him
President Donald Trump has spent 20 months promising that America was on the cusp of an economic boom. But Friday's surprisingly positive jobs report ultimately provoked frustration from Trump.
Armed man charged toward Democratic candidate for Ohio governor at fair, law enforcement says
The Ohio State Highway Patrol says an armed assailant charged toward the Democratic candidate for Ohio governor, Amy Acton, during a campaign stop at the Canfield Fair, injuring several people before he was stopped by troopers.
VETERANS MOBILITY HEALTH EXPO
Team Adaptive Medical is hosting its **First Annual Veterans Mobility Health Expo** to help veterans, individuals with disabilities, caregivers and families connect with mobility resources, healthcare providers and local support organizations.
Midterm elections head into the home stretch as candidates hit Labor Day events
Candidates in several states with competitive House and Senate races are beginning the stretch run of election season with Labor Day events at festivals, union halls and parades.