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Politics complicate push for year-round E15, Iowa Farm Bureau president says
Questions loom over the status of E15 legislation in the U.S. Senate. “Mixed signals is very accurate.” Iowa Farm Bureau president Brent Johnson says he’s heard members of Congress say E15 can’t pass on its own, while others say it can. “So when you look at the makeup of the Senate, I do think we […]
CEO says his fund is investing in Netflix, sees ‘risky business’ in chips
Infrastructure Capital Management CEO Jay Hatfield says Netflix is showing good growth despite being ‘double hammered’ on ‘The Claman Countdown.’
Sports Audio Report: Female Fans
The latest report, Sports Audio Report: Female Fans with Edison Research, SiriusXM Media, and GroupM explores the unique audio listening habits of U.S. female sports fans and shows how they interact with sports beyond the field. Sports audio plays an integral role in female sports fandom – 57% of female sports fans “frequently” or “occasionally” listened to sports audio content in...
20 companies moving forward in Fort Worth Business Plan Competition
The field has narrowed in the 2026 Fort Worth Business Plan Competition, with 20 competitors moving on to participate in several weeks of business
Maryland-Bred Big Cuddle Joins Haskell Lineup
Pocket 3's Racing’s Big Cuddle will face his stiffest test yet in the $1 million, Grade 1 Haskell Stakes at Monmouth Park on July 18, the Daily Racing Form reports. The Haskell field is expected to draw Preakness winner Napoleon Solo and runner-up Iron Honor, as well as G3 Tampa Bay Derby ...
Queen Letizia of Spain Gives Espadrilles a Business-casual Turn
Queen Letizia visited the Zarzuela Palace to speak with professionals working in the field of eating disorders on Wednesday wearing espadrilles.
Landlocked Colorado’s sea-change primary
Colorado’s primary elections held in the doldrums of early summer tend to be routine affairs, most often predictable and by the book. Tuesday’s battlefield was anything but. It is no exaggeration to call it a sea change. Its ripples will shape our state’s politics for many years to come. Writing on this morning after, let’s […]
A Wildlife Regulator’s Family Business Had a Permit to Renew. She Stepped In.
Jenifer Chatfield, a top official at the Interior Department, faces scrutiny from ethics experts for actions that could help her family’s business.
ASU scientists unveil new methods to extract reliable truth from imperfect data
Scientists at Arizona State University are advancing how they interpret complex, imperfect data — challenging long-standing assumptions in fields ranging from imaging to cellular biology. In two papers published in Nature Communications and Proceedings of the National Academy of Sciences, the team introduces fundamentally new approaches to solving “inverse problems,” where researchers work backward from noisy observations to uncover the underlying reality.
Fire breaks out at Springfield business Wednesday morning
Crews are battling a fire at a Springfield business.
People moves: Lucy Fato departs from Seaport Entertainment Group
Seaport Entertainment Group has confirmed that Lucy Fato, its EVP, general counsel and corporate secretary, h
Liverpool transfer news: Jeremy Jacquet officially completes £60m move to Anfield from Rennes
Cleveland Guardians’ Rookie Kahlil Watson Flashing Major League Tools
Cleveland Guardians rookie outfielder Kahlil Watson has shown power, speed, a good hit tool, and solid defense after his graduation to the major league club
Photos: Chicago Cubs 9, San Diego Padres 7
Photos from the Chicago Cubs’ 9-7 win over the San Diego Padres at Wrigley Field on Tuesday, June 30, 2026. ©2026 Chicago Tribune. Visit chicagotribune.com. Distributed by Tribune Content Agency, LLC.
Magic find out group pairings for upcoming NBA Cup
The Magic on Tuesday night drew a compelling group for Group Play of the NBA Cup, the league’s fourth-ever in-season tournament. Orlando was placed in East Group A alongside Detroit, Toronto, Milwaukee and Brooklyn. The tournament — which will consist of two stages including Group Play and the Knockout Rounds — starts Oct. 30 and will end with the title game (Dec. 11) at Hinkle Fieldhouse ...
Jena Griswold leads early returns in Colorado’s Democratic attorney general primary
Colorado Secretary of State Jena Griswold led the field of Democratic attorney general candidates by a wide margin in early returns posted minutes after polls closed Tuesday night. Four Democrats are running for the office held by term-limited Democratic Attorney General Weiser, who is running for governor. In addition to Griswold, who is serving her […]
Anthropic's New AI Workbench Mapped My Field For $26. Now Imagine It Aimed At The Rest Of Science
Anthropic's Claude Science is a capable AI research workbench built for molecular biology. The opportunities for the rest of science are enormous.
New to politics, Skovgard throws his hat in the race for U.S. Senate
CODY — In the Parable of the Sower, a sower throws seeds out in a field, and some are choked by thorns; others are eaten by birds; some fall onto
These NFL power couples dominate the field, entertainment world
Travis Kelce and Taylor Swift could be wed as soon as this week. Here are other partnerships between NFL and celebrity stars.
Contract extension marks 'fresh start' for Taylor
Midfielder Fraser Taylor is relishing a "fresh start" under new St Mirren boss Craig McLeish after signing a two-year contract extension. The 23-year-old academy graduate, whose deal now runs to summer 2028, made his first-team debut in 2022 and featured 13 times for the Buddies last season before joining Partick Thistle on loan in January. "I'm really pleased, since the new manager has come in, he spoke to me on the off-season, and his ideas really suit the way I like to play," said Taylor.
Viewpoint: We must support girls in outdoor science fields
Marilyn Marler writes, Studies show that girls start losing interest in science and math around middle school and, as a result, women are often underrepresented in these professional fields.
Tennessee transfer infielder Manny Marin commits to Arkansas
Tennessee transfer infielder Manny Marin has committed to Arkansas via the NCAA Transfer Portal. The former Volunteers star made the announcement via his Instagram page. — This story is developing and will be updated. Check back momentarily.
Milwaukee Brewers' Joey Ortiz Delivers Heroics in Late Innings
Facing roster pressure after a top prospect's arrival, the infielder silenced critics with a clutch eighth-inning blast to secure a vital victory and solidify his place with the Milwaukee Brewers.
What Botox, rat poison and venoms can teach students about science
New University of Nevada, Reno course builds scientific thinking skills for future science-related fields
The footballer swapping the pitch for the beach
Erin Bloomfield plays and coaches at Sherborne FC, but also represents England on the sand.
Andrew Benintendi sends message with Madeira Field of Dreams donation
Chicago White Sox outfielder and former Madeira High School standout Andrew Benintendi donated to the Madeira Field of Dreams project.
Andrew Benintendi sends message with Madeira Field of Dreams donation
Chicago White Sox outfielder and former Madeira High School standout Andrew Benintendi donated to the Madeira Field of Dreams project.
Brewers' win over the Reds featured 3 desperately needed performances
Three Brewers mired in deep funks came up big to help beat the Reds on June 29 at American Family Field.
Reds' Dane Myers carted off field after ridiculous catch, scary collision with wall in loss to Brewers
Dane Myers snagged a deep shot before slamming into the wall on Monday in Milwaukee.
Cara Delevingne confirms she and Amber Heard were romantically involved amid actress' Johnny Depp divorce
Model-actress Cara Delevingne confirms she and 'London Fields' costar Amber Heard were romantically involved amid actress' divorce from Johnny Depp.
Yankees Announce Updates on Giancarlo Stanton, Max Fried
Two of the Yankees' injured stars will be working together in their return to the field.
Yankees Promote Cody Bellinger’s All-Star Candidacy Before Tigers Game
The New York Yankees made a social media post concerning left fielder Cody Bellinger.
Dodgers Reinstate Teoscar Hernández from Injured List
The Los Angeles Dodgers brought back outfielder Teoscar Hernández from the injured list with a hamstring strain on Monday.
Who Wore It Best: 1
You’d think there’d be more demand from top players for the number 1 on the back of the jersey, especially since it was worn by some notable players. However, it has largely been the designation of contact first, defensively solid infielders over the years and the Jays are no exception. When the Yankees and Indians […]
Ravens Rookies Expected to Make Immediate Impact in ‘Projected Roles’
The Baltimore Ravens are known for drafting players who can make an immediate impact on the field. For example, look at Kyle Hamilton.Hamilton is already a three time All-Pro after being drafted by Baltimore in 2022. In this year’s draft class, Baltimore’s draft picks have the same potential to make an immediate impact as soon […] The post Ravens Rookies Expected to Make Immediate Impact in ‘Projected Roles’ appeared first on HEAVY.
Small business is about people helping people
Local Chamber president Mike Murphy says it means jobs for our community.
Resident Evil Veronica Finally Gives Claire Redfield Her Due – the Horror Series’ Most Ignored Character Deserves the Spotlight
Despite being in plenty of spin-offs and crossovers, Claire Redfield is in barely any of the mainline Resident Evil games. After a long time away, RE Veronica is finally set to give Claire her due.
Wa-Hi junior Lars Sandven selected for prestigious national science camp
The residential summer camp provides academic and leadership experience in STEAM fields.
A Salt Lake City school’s new sports complex features a huge turf field. Neighbors say it’s a heat island
One couple said they’re no longer able to enjoy their yard because it now reeks of hot rubber.
Passback finds new life for old sports equipment, equipping youth to take the field
Magdalen Sparrow grew up on St. Louis’ soccer fields chasing after stray balls and picking up lost water bottles to put in overflowing lost and found bins. Then known by her maiden name, Magdalen Pike, she went on to play D1 soccer at Southeast Missouri State University, accumulating a closet full of sports gear in […]
How Jude Bellingham SAVED England against Panama
England are through to the World Cup knockout rounds following a 2-0 win over Panama. But after another sluggish start, which looked for a while like it could be a repeat of the Ghana game, Jude Bellingham both scored and assisted to get England through. Adam Clery looks at how, without Declan Rice in the side, Bellingham played every single midfield role to drag Thomas Tuchel's side to a vital win.
Just hopes agent is 'busy' after World Cup impact
Elijah Just hopes his agent is "busy at the moment" as the New Zealand midfielder hinted at a possible summer exit from Motherwell after impressing at the World Cup. Just only joined Motherwell from Danish club Horsens a year ago and is under contract until next summer, with the Scottish Premiership club having an option of extending that by a further year. "The World Cup has given me added belief and also motivation to keep pushing," Just told the NZ Herald.
Russian 6th to 11th graders get 17 hours of basic military training
Russia is doubling the amount of military training time in high schools, with new lessons on drones and field exercises.
Baker Mayfield Drops Clear Message on Kyler Murray
As Kyler Murray seeks a fresh start in Minnesota, former teammate Baker Mayfield defends the polarizing quarterback, predicting a dominant resurgence fueled by a much-needed change of scenery.
New Mexico Sports Hall of Fame 2025 inductees honored at banquet
Anita Maxwell, John Fields, and Miles Watters -- 3 of the 5 members of the class of 2025 -- were at the celebration.
Buccaneers place two offensive leaders on CBS Sports Top 100 list
Tristan Wirfs and Baker Mayfield represented the Buccaneers on Pete Prisco’s CBS Sports Top 100 players list, highlighting Tampa Bay’s offensive core.
Huddersfield hold off Barrow fightback
Winless Barrow Raiders' late fightback is to no avail as Faye Barraclough's four tries help Huddersfield Giants to a 30-24 victory.
Lille reveal Ayyoub Bouaddi stance amid Liverpool interest
Liverpool Face Patient Lille Stance Over Ayyoub Bouaddi TransferLiverpool’s interest in Ayyoub Bouaddi has moved into sharper focus, with AS reporting that Lille are prepared to take a patient appro...
Toronto Blue Jays Infielder Delivers Simple Message to Fans
Ernie Clement was named an All-Star Game starter earlier this week.
These tiny soil microbes could rescue crops from salty farmland
Researchers have discovered that beneficial soil bacteria give plants an unexpected survival advantage in salty soils. Instead of helping plants keep salt out, the microbes stimulate the production of lignin, a natural compound that strengthens roots and makes plants more resilient. Greenhouse and field tests showed healthier plants and higher yields in salty conditions. The findings could lead to bio-based treatments that help farmers grow crops on land once considered too salty for agriculture.
VIA Women’s Health Collective celebrates grand opening
By Megan Dial VIA Women’s Health Collective, 17300 Westfield Blvd., Suite 330, celebrated its grand opening June 18 with the Westfield mayor, Westfield Chamber of Commerce and other community supporters. Dr. Taylor Hahn said she founded VIA Women’s Health Collective to support women in every s
Kerry loss 'will take a while to get over'
Tyrone midfielder Conn Kilpatrick says the 2-25 to 0-27 All-Ireland SFC quarter-final defeat by Kerry will "take a while to get over".
‘AIDS is not over:’ Behind a local group’s awareness campaign for HIV funding
Walk through East Liberty, Bloomfield or other Pittsburgh neighborhoods and you might see flyers with black-and-pink block print and an urgent message:...
US Oilfield Business Activity Strengthens, Though Oil Price Uncertainty Remains
The Federal Reserve Bank of Dallas’ second-quarter energy survey reports improved business conditions, despite a mixed outlook on oil prices and input costs.
Dodgers getting stronger, planning to activate Teoscar Hernández
The Los Angeles outfielder has been on the IL since May 29 with a hamstring strain.
Game 84: Rockies at Twins
First Pitch: 6:10 pm CDTTV: Twins.TVRadio: TIBN / WCCO 830 / The Wolf 102.9 FM / Audacy One night after what many are already calling the dumbest game of all time, Target Field is playing host to the Battle of the Mikes. Mike check, one-two, one-two. Heh. Hilarious. For the Twins, it’s Mike Paredes, who has […]
Report: Crystal Palace Eye Smart Move for Experienced Arsenal Midfielder
Crystal Palace Eye Christian Norgaard as Arsenal Exit Route OpensPalace Consider Midfield ExperienceCrystal Palace appear ready to offer Christian Norgaard a route out of Arsenal this summer, with Spo...
New York Knicks Champion Mitchell Robinson Makes Heartfelt Post
Mitchell Robinson is coming off his eighth season in the NBA.The 28-year-old has become an extremely valuable player for the New York Knicks in that span.He is coming off a season where he averaged 5.7 points, 8.8 rebounds and 1.2 blocks per contest while shooting 72.3% from the field in 60 games.Knicks Champion Robinson Makes […] The post New York Knicks Champion Mitchell Robinson Makes Heartfelt Post appeared first on HEAVY.
Andy Burnham distanced himself from UK Prime Minister Starmer, but may be stuck with his policies
Burnham, the former mayor of Greater Manchester who was sworn into Parliament hours after Starmer announced his resignation on Monday, will be constrained by the platform the center-left Labour Party was elected on that decisively ended 14 years of Conservative rule in 2024.
Sky Sports: Everton are in the race to sign Serie A midfielder
Everton Transfer News: Mandela Keita Emerges as Midfield TargetEverton continue to search for midfield reinforcements this summer, with Sky Sports reporting that Parma’s Mandela Keita has emerged as...
Exit statement from midfielder baffles Real Madrid fans
Real Madrid confirmed what had been an open secret on Friday, that Dani Ceballos would be leaving. The 29-year-old has been a bit-part player for some time, but continued reports about his exit seemed...
Browns Warned Over Deshaun Watson Decision
The Cleveland Browns can insist that their quarterback competition between Deshaun Watson and Shedeur Sanders will be decided on the field, but the decision will not be made in a vacuum. The post Browns Warned Over Deshaun Watson Decision appeared first on HEAVY.
Mo Salah moves closer to €80m contract deal
Following a poor campaign - both individually and collectively - the Egyptian King reached an agreement to rip up his £400k per week contract one year early.The 34-year-old is currently strutting his...
Seattle World Cup match brings fans, Pride weekend, and global politics together
The World Cup’s stop in Seattle has already delivered packed streets, record-setting business days and a surge of international energy around Lumen Field.
Good Sports: Former Bulldog track and field athlete aims to be flag football Olympian
Last June, Kaja Bins didn't know what flag football was. Kaja now has the potential to become an Olympian in a sport she learned a year ago.
Kern County Public Health reports first detection West Nile virus for 2026
Kern County health officials have confirmed the first mosquito sample of the year has tested positive for West Nile virus, a development that is prompting
Police seek help identifying suspect in California Avenue business break-in
The Bakersfield Police Department is asking for the community’s help in identifying a man accused of breaking into a business on California AvenuePolice said it
Tourism tax dollars to drive $25M makeover of John R. Jones Sports Complex in Pensacola
PENSACOLA, Fla. -- The John R. Jones Sports Complex will soon undergo a makeover. When it's complete, it is expected to be one of the premiere athletic fields i
Guardians score, lineups vs Seattle Mariners at Progressive FIeld
The short-handed Guardians look to find some offense against the Mariners at Progressive Field. Follow along here for live updates.
Kristen Stewart and Alia Shawkat are 'The Wrong Girls' in first look at new stoner comedy (exclusive)
EW has your exclusive first look at the stoner comedy 'The Wrong Girls' from writer-director Dylan Meyer, starring Kristen Stewart, Alia Shawkat, LaKeith Stanfield, Seth Rogen, and Kate McKinnon.
Kristen Stewart and Alia Shawkat are “The Wrong Girls” in first look at new stoner comedy (exclusive)
LaKeith Stanfield, Seth Rogen, Kate McKinnon, and Geena Davis also star in the Neon film.
Health fears as Brimpsfield water cut off on hottest days
Village residents criticise Thames Water after saying they have been left without water for 48 hours.
CT Summer Fair brings live entertainment, carnival rides, and more. ‘30,000 expected to celebrate
Suffield’s 6th Annual Summer Fair is running through Saturday, June 27, according to a statement.
How Science and Music Blurred Politics One Day Back Home
What to expect when you talk and play music to people you grew up with but have not seen for decades and have different political views from you. Turns out it was fabulous.
How Science and Music Blurred Politics One Day Back Home
What to expect when you talk and play music to people you grew up with but have not seen for decades and have different political views from you. Turns out it was fabulous.
Battlefield 6 is altering its long-range gunplay to feel more like Battlefield 4
In just a few short days, Battlefield 6's combat encounters could potentially play out a lot differently from the way they do today.
Memorial Health Championship in full swing in Springfield
Organizers are also offering additional attractions beyond golf, including food trucks, the Scheels Fan Zone and Family Fun Day on Saturday, which features a superhero theme for children and families.
Robot startup FieldAI achieves $100M milestone in revenue, contracts
FieldAI says it has crossed $100 million in revenue and contracts by building software for robots to work in mines, construction sites, and factories.
What could be next for Gakpo?
Following the departure of Mohamed Salah, at least one more attacking signing is expected at Anfield this summer. Liverpool have already signed Victor Munoz from Osasuna for £34.5m and the pursuit of Yan Diomande is heating up. Talented teenager Rio Ngumoha is also set to play a more prominent role, while Florian Wirtz played off the left for Liverpool at times last season and is featuring there for Germany in the World Cup.
‘Turf Tank’ robot elevates Oregon sports fields
The Oregon Youth Soccer Association is taking advantage of some new technology to keep its fields game day ready.
The Big Summer Preview – New Starter Sets and ready painted terrain
Dive into Warhammer 40,000, and fight on the battlefields of Armageddon with new terrain kits.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Ohio politicians respond to Supreme Court TPS ruling for Haitians and Syrians
The decision impacts more than 350,000 Haitians and 6,000 Syrians across the country, including many in Ohio.
Edgefield County health fair offering free screenings, vendors, and entertainment
JOHNSTON, S.C. (WJBF) — A free community health fair is headed to Edgefield County. “Prevention Today for a Healthier Tomorrow,” set for Friday, June 26 from 10 to 1 at Strom Thurmond High School i…
Honoring the best in small business
Fifth Street Renaissance, Resource One, Cured Catering, and ChangeBridge Consulting are all honored.
REV Entertainment Announces Enhanced 2027 College Baseball Series Slate
REV Entertainment announces the 2027 College Baseball Series, featuring seven tournaments across five locations. Find full team fields, dates, and additional info here!
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How should European scientists respond to the US AI kill switch?
Earlier in June, Europe’s worst fears of technological dependence were confirmed when the White House ordered the AI firm Anthropic to stop non-US citizens using its leading models. This kill-switch moment crystalised anxieties in Brussels that the continent, lagging the US on the creation of leading-edge AI models, is now a technological of vassal of Washington. The shock has specific implications for European scientists and universities. Some governments are now worried that with AI being integrated into labs, Donald Trump now has his finger hovering over an off switch for European science. “Having restrictions on this tool, it can have an impact on our own research,” said France’s research minister, Philippe Baptiste, at the VivaTech conference in Paris on June 18.Baptiste, himself a former academic, said that colleagues in mathematics had recently warned him they were now cut off from leading-edge US models, risking their work. “This model is not available anymore now because of the US restriction, and for the first time this had an impact on mathematics,” a field where large language models (LLMs) are making a significant contribution, said Baptiste. So, should European scientists avoid relying on US models in the future? Or would this be a self-harming overreaction? And how is AI being used in science, anyway? What happened?On June 12, it emerged that Washington, citing cybersecurity concerns, had ordered Anthropic to stop non-US citizens using two models: Claude Mythos 5, and Claude Fable 5, a version of Mythos but with guardrails to prevent abuse. Anthropic said Washington’s concerns were overblown. But forced to follow the order, yet with no way to check who was using the models, the company suddenly shut down access for everyone, US citizens included. There’s still no agreement on how to restore broad access. But last week, Bloomberg reported that select US companies, and the US government, still had access to Mythos despite the ban, but the EU’s cybersecurity agency Enisa had been shut out. Class division of researchersIn the longer term, access outside the US should be restored, said Marcel Salathé, co-director of the AI centre at the Federal Polytechnic School of Lausanne (EPFL), because a permanent restriction would be financially ruinous to US AI firms. “Even Trump will eventually budge to economic pressure,” he said.However, US AI firms might end up operating rather like banks, doing due diligence on users of their leading-edge AI models, he went on.European scientists are unlikely to fall foul of such checks, he said. But having a Chinese postgraduate in their lab, or doing a type of research the US disapproved of, could potentially result in access being denied. “It will create a sort of class division of researchers,” he said. More than frontier modelsHowever, successfully deploying AI in science is about far more than just having access to leading LLMs such as Mythos.Instead, many science-specific tools, most famously Alphafold, which predicts protein folding structures, require “far less” computing power to train than frontier models, well within the capabilities of European supercomputers, according to a recent analysis by the Arq Foundation, a Brussel-based AI think tank. Instead, tools such as Alphafold are possible because certain fields, like protein folding, weather prediction or astronomy, have large, clean, standardised datasets that can be used to train predictive models. Rather than compute, “data is the central constraint for AI for science,” the report says. For example, a less powerful physics model trained on CERN’s data “will be more valuable than the best model without certain data,” said Bengüsu Özcan, author of the report. European advantage?Europe could therefore steal a march by using its scientific data and infrastructure to create models US digital giants cannot. “They might actually match or go even beyond what these big [US] companies are doing,” said Özcan.Indeed, some European start-ups hope to create automated testing labs to create the kind of standardised data that could speed up the discovery of new materials. Materials scientists say there’s currently too little data to train models. AI scientistsHowever, even if the bottleneck for AI in science is often data, rather than compute, being at the mercy of the US for LLM access could still become a problem for European scientists. A new class of “AI scientists” based on leading LLMs is also emerging, Özcan’s report says.Unlike domain-specific tools like Alphafold, these try to automate day-to-day scientific work, by providing an overarching tool that coordinates specific models to synthesise existing literature, generate hypotheses or run analysis of data. The problem for Europe, however, is that these tools are sometimes based on US leading models. Google Deepmind’s AI Co-Scientist, for example, is built on Google’s Gemini LLM. Systematic failureThese scientific automation tools are still in their early stages, and still exhibit “systematic failures on scientific tasks,” Özcan’s report says. One of the problems is that the messy, day-to-day process of scientific discovery is largely not documented, meaning LLMs don’t have a good source of data to learn how scientists actually work. Meanwhile, some tasks, such as literature synthesis, don’t typically require access to leading edge models.However, the performance of AI scientific assistants could improve as companies such as Google pour resources into developing them. Rely on US“Unfortunately, for scientific assistants, there is not much we can do right now except rely on US frontier AI,” said Antoine Bosselut, a natural language processing expert based at EPFL. Chinese-built open models, which can run on local computers, lessening the risk of a shutdown, are touted as one alternative to US dependence. There’s also Mistral, once seen as Europe’s main AI hope, but the Paris-based company has seen its recent models fall behind in performance. But the Chinese alternatives are generally not as capable as US frontier AI models, said Bosselut, unless paired with fiddly, custom tools that allows them to act as independent agents. “Most scientists do not have the time,” he said. Don’t jump ship yetAlthough the kill switch moment is seen a warning shot for European scientists, it doesn’t mean labs should abandon US AI tools immediately. “I do not think the right response is simply to abandon US-based models and systems under the banner of sovereignty or independence,” said Mattias Björnmalm, secretary general of the Cesaer university association. “That would be an overreaction.”Related articlesEuropean sovereignty in AI requires ‘ugly trade-offs,’ say experts Robotic lab start-up makes case for €500M EU-funded materials testing facilityAI in science: is it useful? Instead, European researchers need to ask themselves whether they’re becoming dependent on technology that could be turned off in Washington, said Özcan. “They might not see this today, but they should really start asking this question,” she said. European researchers need a plan B, said Salathé. “I would recommend to every researcher, very proactively explore alternatives.”Own toolsIn addition, Björnmalm and others want European research institutions to develop their own scientific AI tools.Instead of signing AI deals with US digital giants, European universities should be using this money to create their own models, which may end up being superior for research, said Sabine Leonelli, an expert on the use of AI in science at the Technical University of Munich. “Universities in Europe seem to be happy to sign commercial contracts with US companies on the assumption [their AI tools] are better,” she said. But US frontier LLMs are typically opaque, and have been developed without independent scientific input, she said. “This is not good enough for science.”Last year, Swiss researchers released Apertus, an LLM designed to be completely transparent, from its development methods to its training data. The idea is that this makes scientific tools built on top of the model far more reproducible than with closed, commercial alternatives.“Europe needs more of this: serious capacity-building that gives researchers, universities and companies credible options,” said Björnmalm.
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