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GameSquare Enters Definitive Contribution Agreement to Acquire Sports, Music and Entertainment IP Assets from FanEngine
("FanEngine"), a technology and media asset consolidator that collectively enables sports, music and entertainment IP owners to build direct relationships with fans and monetize those relationships through gamification, brand integration, events, content, commerce, and experiences.The Transaction is expected to be immediately accretive to profitability and represents the next step in GameSquare's strategy to build a differentiated, end-to-end platform spanning audience analytics, creators, agenc
GameSquare Enters Definitive Contribution Agreement to Acquire Sports, Music and Entertainment IP Assets from FanEngine
Highly profitable transaction expected to be immediately accretive to earnings and support multiple recurring revenue opportunitiesFanEngine's assets add well-known global IP assets Peaky Blinders, Simon's Cat, The Two Robbies and Friends, 4Cast Media Platform featuring Former England Captain Ben S…
iPhone 18 Pro Details Purportedly Leaked By Verizon's AI Assistant
A series of screenshots shared with MacRumors today seemingly show Verizon's AI chat assistant answering detailed questions about the iPhone 18 Pro and iPhone 18 Pro Max, just hours before Apple's announcement event. The screenshots were shared privately with MacRumors by X user "mehrtosh," who says the responses came from the "Ask Verizon" AI assistant built into the carrier's app.
Arbeloa needs 'positive support' but defence is 'comical'
Rohan: I feel as though Arbeloa has completely underestimated the physicality of the Premier League. Without signing another centre-back as a partner for Calvin Bassey, he has allowed other players to breach the right of our defence easily. Arbeloa needs to find a way to counter this so we can start picking up points.
Eberl reveals Bayern explored move for Barcola before Liverpool switch
Bayern Munich were linked with a move for Bradley Barcola in the past, when he was still playing for Paris Saint-Germain, but ultimately chose not to pursue their interest.In an interview with Sport B...
Military Toxic Exposures Appear to Affect Both Mental and Physical Health in Veterans
Environmental hazards encountered during military service, such as Agent Orange and toxins from open-air burn pits, are known to be linked to adverse physical health outcomes. The VA recognizes them as presumptively service related under the Agent Orange Act of 1991 and the Promise to Address Comprehensive Toxics Act of 2022.
Foldable iPhone Duo to Come With Apple Pencil Support
Apple's foldable iPhone Duo will come with Apple Pencil support, reports Bloomberg's Mark Gurman. Gurman previously claimed that Apple had prototyped a dedicated Apple Pencil for its foldable iPhone that was "stubbier than the versions for iPads" and "designed to magnetically attach and charge on the side of the device," but he said it was unlikely that the accessory would be released.
First on CNN: Routine blood testing may hold hidden clues to colorectal cancer before age 45
When you have your blood drawn in a routine doctor’s visit, some of the markers in your blood that get tested could hold unexpected clues to how likely you are to develop colorectal cancer at a young age, new research suggests.
14 of Science’s Biggest Mysteries We’re Still Trying to Figure Out
There’s a lot we know today that humanity didn’t know hundreds of years ago, and there will likely be a lot people will learn in the coming years that we can’t possibly know right now. Among these que...
Apple expected to unveil first folding phone, with new CEO Ternus in command
Apple is widely expected to unveil a pricey folding iPhone at a launch event on Wednesday at its Cupertino, California, headquarters.
The wildest sport you’ve never heard of has some unlikely stars: American cowboys
Nine American cowboys joined thousands of global athletes in Kyrgyzstan for the World Nomad Games, competing in Kok-Boru — Central Asia’s ancient, brutal sport of equestrian goat-grabbing.
Maven Securities LTD Makes New $2.28 Million Investment in Live Nation Entertainment, Inc. $LYV
Maven Securities LTD acquired a new stake in Live Nation Entertainment, Inc. (NYSE:LYV - Free Report) during the second quarter, according to its most recent disclosure with the SEC. The institutional investor acquired 12,470 shares of the company's stock, valued at approximately $2,283,000. Other
Epic v. Health Gorilla: “Working as Designed”
We’ve been on a bit of a legal bender since just before Labor Day, so let’s keep a good thing going! As predicted, Epic does not want its case against Health Gorilla consolidated with the data breach cases, so it filed a motion to vacate the conditional transfer. And because they had to explain to the Panel why this case is different, they put a good chunk of previously unseen Epic v. Health Gorilla discovery record on the public docket! Roll the tape! The Case Against Consolidation Before we get to the fun stuff, let’s do the housekeeping. Epic's motion boils down to three arguments (sorted in ascending order of how well they land): A judge has already decided this. Judge Olguin declined to relate the fraud action to another ELU case (Patterson v. UVA Health), holding that the two do not call for determination of substantially similar questions of law or fact. Epic asks the Panel to treat that (a Rule 42 ruling) as law of the case. The overlap is thin. The three common questions Health Gorilla and the Panel identified are neither numerous nor complex (the qualities the Panel looks for before centralizing). Moreover, they are outnumbered by the questions unique to each side: The breach cases turn on security architecture, notification timing, and patient-level access. The fraud action turns on false treatment attestations and breaches of the framework agreements. Consolidation costs more than it saves. 17 of 21 parties in the fraud action do not appear in a breach case. The cases are also at very different stages: Olguin has a scheduling order running through a January 2028 trial while the breach actions are much more nascent. I like the last two more than the first because they attack the basic economics of an MDL: there just may not be enough shared discovery here to justify dragging all the defendants and a relatively mature fraud case all the way to Florida. On the other hand (while I know exceedingly little about MDL and Rule 42), I have a hard time seeing why a district judge's decision about his own docket would control what the Panel does with the separate § 1407 question. I might be reading between the lines too much, but I sorta think Epic's own brief half-concedes this, framing the two provisions as "two sides of the same coin" but then adding "respectfully submit" (which is often lawyer speak for “we know this is a reach”). The Ladder Gets More Rungs Anyway, the arguments are not why you're here (aside from the lawyers, maybe). Back in June, we discussed how Epic was using the smaller defendants to build an evidentiary ladder toward Health Gorilla and Unit 387. Turns out discovery has been adding a few rungs of its own.
Toulouse confirm impending Mark McKenzie exit
Toulouse FC president Olivier Cloarec has confirmed that Mark McKenzie (27) is highly likely to leave the club in January and return to his native USA.It was reported by The Athletic during the transf...
8 events in Lancaster County this weekend, from a whoopie pie festival to an herb fest
There's a lively weekend on tap for Lancaster County.
New outpatient clinic focused on suicide prevention opens in Burlington
University of Vermont Health held an open house last week to celebrate the opening of the Asha Clinic, which it describes as the only program in the region focused exclusively on suicide care. The clinic's work is led by Craig Bryan, an expert in suicide treatment and research.
A rare thing in American politics may happen in Rhode Island on Wednesday
Gov. Dan McKee barely beat Helena Foulkes in 2022. For Wednesday’s rematch, the former CVS executive has outraised him and appears well positioned to win.
Did New Film Unit Just Shift AMC Stock’s Investment Narrative?
AMC Entertainment Holdings recently launched Leawood Films, a film distribution unit based in Los Angeles and Leawood, Kansas, aiming to bring more small and mid-sized movies into theatres worldwide while relying on fully financed projects to limit production risk. The new distributor uses AMC’s excess screen capacity and past concert-film marketing experience to secure theatrical placement for filmmakers who might otherwise struggle to find backing, while leaving most downstream revenue and...
Oui Entertainment’s new eight-member boy band to debut in 2026
The agency behind WEi plans to debut its new multinational group, tentatively called Ouiboys, by the end of 2026.
Lane Kiffin and Livvy Dunne Just Made LSU Cool Again
I’m not saying Lane Kiffin is the most entertaining hire LSU has made in years. I’m just saying Livvy Dunne is suddenly back around LSU football. Coincidence? Absolutely. But let me have my fun. Dunne returned to Baton Rouge for LSU’s season opener against Clemson, watched the Tigers absolutely demolish the Tigers 51-10 and showed…
We Need to Have a Conversation About Angel Reese
Angel Reese gets treated like a superstar. But are we sure she actually is one? Nobody can deny the rebounding. Nobody can deny the production. Reese is averaging 16.1 points and 12.4 rebounds this season, which is objectively impressive. But the WNBA is becoming increasingly loaded with elite players, and the bar for being called…
'I cannot take my eyes off Bouaddi
Ayyoub Bouaddi belied his age with a mature Champions League performance on his first Manchester City start to showcase why the club were so intent on signing the 18-year-old. Erling Haaland will take the plaudits for his two goals, but it was Bouaddi who caught the eye with a tidy and assured performance in the middle of the park, signalling early signs that Rodri may not be too sorely missed after his departure. "His age, his game – he looks absolutely born to do it," former Chelsea winger Pat Nevin said on BBC Radio 5 Live during the game.
From moving people to managing them
Transportation policy used to have a fairly uncomplicated purpose: move people safely, efficiently and reliably. Build roads where people drive. Maintain bridges before they fail. Add capacity where growth overwhelms the system. Provide transit where it makes sense. Infrastructure was supposed to accommodate human behavior. Colorado increasingly prefers the opposite arrangement. Today, transportation policy is […]
Google warns of new Chrome zero-day bug exploited in attacks
Google has patched 230 vulnerabilities on Tuesday, including another actively exploited Chrome zero-day bug, the seventh such vulnerability patched since the start of the year.
MidCap Business Credit Closes $10MM Asset-Based Credit Facility for Paper Converter
MidCap Business Credit closed a $10 million asset-based credit facility for a privately held paper converter specializing in custom paper products for
49ers defensive lineman Alfred Collins' injury latest blow to largely unproven unit
San Francisco 49ers second-year defensive lineman Alfred Collins tore his patellar tendon at the team's second practice in Melbourne and will be out for the season, coach Kyle Shanahan said.
Explore the universe
Within a relatively short drive, there are opportunities to explore the universe.
Baker Mayfield Agrees to Extension After ‘Disrespectful’ Buccaneers Offer
Baker Mayfield walked off the field in Jacksonville last month after a scoreless preseason finale, hardly the tune-up a quarterback wants heading into a contract year. Weeks earlier, the Tampa Bay Buccaneers passer had called the team’s opening offer ‘disrespectful’ and shut down extension talks completely. That standoff loomed over training camp all summer. Now, […] The post Baker Mayfield Agrees to Extension After ‘Disrespectful’ Buccaneers Offer appeared first on Gridiron Heroics.
Guess Whose Back!? Dbacks 5, Royals 3. F/11
On Tuesday the Dbacks were able to get to a season high 10 games over .500 as they beat the Kansas City Royals in 11 innings. The story of the game was Corbin Burnes’ return to the team, but the guys that stole the show at the end were of an unlikely variety as there […]
Detmers dominates deficient Red Sox in 6-1 Angels win
Tomorrow marks the end of a stretch in which the Red Sox play 54 games in 56 days (dating back to July 17th), and I’m kind of thrilled about that because I’m extremely over these half baked games. Tonight in particular was just a bad combination of events. Reid Detmers, who has been outstanding since […]
Vikings Projected to Likely Strike NFL QB Deal Before Deadline
Bleacher Report's Alex Kay named Minnesota Vikings quarterback J.J. McCarthy the most likely signal-caller to be traded during the 2026 NFL season. The post Vikings Projected to Likely Strike NFL QB Deal Before Deadline appeared first on HEAVY.
Braves outshined by Rays’ stars in series-opening loss
Kicking off a critical late-season homestand Tuesday night against the Tampa Bay Rays, a breakthrough performance from AJ Smith-Shawver on the mound or a strong performance from its star hitters could have been enough to deliver the Atlanta Braves a tone-setting win. Unfortunately for them, they got neither of those. An early exit from Smith-Shawver […]
West Virginia State Police cadets to begin mental health crisis training September 9
West Virginia State Police cadets will begin Keystone Model crisis training Sept. 9. Classroom lessons and realistic simulations will teach them to recognize behavioral health emergencies, communicate effectively and safely de-escalate encounters.
Marlins' Brian Navarreto Finding Value Beyond Bat
Miami’s veteran backstop has endured a difficult offensive year while continuing to provide the Marlins with dependable work behind the plate and timely contributions.
Scientists in Chicago remotely controlled a wireless brain implant in South Korea over the internet
"The biggest challenge is demonstrating long-term safety and reliability in the human brain."
Trump transport chief blasts Ford’s business deals with Chinese firms
CEO Jim Farley hit back, saying the letter urging him to cut ties with firms like China’s CATL, Geely and BYD was ‘wrong-headed’.
Apple wanted the iPhone Ultra to cost $1,999, new report says
But the RAM apocalypse intervened. Apple is holding its big annual iPhone launch event on September 9, and it's widely expected to unveil the iPhone Ultra...
Why Kayshon Boutte could be immediately fantasy football relevant
Boutte will be making plays alongside Nico Collins
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Glendale Actress Finds Love of Science
A few years ago, Marilyn Heidecker was more likely to portray a criminalist on TV, film, or stage rather than work as an actual scientist who analyzes physical evidence in
Putin and Trump discuss Ukraine in 'extremely frank' call
Washington has been pushing for fresh face-to-face talks between Moscow and Kyiv to reach a peace deal
Monster Jam coming to Gwinnett this weekend
Long before she made a name for herself on the insanely popular Monster Jam circuit, Kayla Blood approached and cleared her share of hurdles.
Kaelen Culpepper Sets a Defensive Goal for Twins’ Final Month
Culpepper’s work at shortstop gives Minnesota another reason to watch his September closely, alongside an encouraging start at the plate.
Video: Opinion | The ‘Hyperpoliticization’ of American Politics
Anton Jäger argues on “The Ezra Klein Show” that we’re in a distinct era of “hyperpolitics” — where politics feels volatile, ubiquitous and intense, but is not securely attached to institutions and structures.
Jamison Battle’s Preparation Could Earn Him More Raptors Minutes
Toronto has a reserve shooter worth examining closely, especially when his limited opportunities arrive without much warning.
From Backyard Ziplines to Self-Driving Cars: UCLA Computer Science Student Develops Tools to Help Autonomous Vehicles Safely Share Information
One of the fondest childhood memories of Alexandra Markova was a weekend spent running around Home Depot with her father and three siblings.
Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk
The Kansas City Chiefs fans are still not completely certain whether Patrick Mahomes will be starting in the season’s opening Week 1 game. The team suffered heavily last season when the quarterback suffered an ACL injury that has kept him out for a long time. He has missed the entire offseason, including the preseason games. […] The post Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk appeared first on Gridiron Heroics.
3 Takeaways From the Latest PISA Test of Reading, Math, and Science
The results show reading performance dropping across the world—and one uniquely troubling U.S. trend.
Eye on Health: Couplet Care keeps families and babies closer during NICU stay
The NICU..or Neonatal Intensive Care Unit is designed for babies requiring special care immediately following birth. But not every NICU looks the same."The most
Florida high school football coach fired after just three games
Dan Nieboer was hired away from Jason Witten's Liberty Christian staff in Texas to lead Lely (FL). After an 0-3 start, he's been let go.
College Football Has Completely Lost Its Mind
College football has been back for one full week . That’s it. And somehow we already have a tweet perfectly summarizing just how ridiculous this season has become. LSU is dealing with a legal fight that has reached the point where SEC leaders could vote on whether to expel the school from the conference. Western…
Dunlap highlights high home heating oil prices in Maine
Dunlap, who faces former Republican Gov. Paul LePage on the Nov. 3 ballot, said Maine continues to be the state where more people rely on home heating oil than any other.
Texas’ Biggest Concern Going Into Saturday Is This
Texas has one of the most talented offenses in college football. But if the Longhorns want to finally beat Ohio State on Saturday night, they have to find a way to push the football down the field. That was a massive problem last year. Ohio State completely suffocated Texas’ passing game for most of its…
Northrop Grumman lands defense contracts worth $1.37B
Falls Church-based defense supplier Northrop Grumman landed two major military contracts collectively worth $1.37 billion.
SEC sets meeting to discuss booting LSU from conference
The Tigers didn't ultimately add any NFL players to their roster ahead of Week 1, but that hasn't stopped the SEC presidents' crusade against them.
“Furious” creator breaks down season 1 finale and teases what’s next for Alice
“I’m definitely not using the show as a platform to advocate murdering people,” Meriwether tells EW.
‘Furious’ creator breaks down season 1 finale and teases what’s next for Alice
‘Furious’ creator Liz Meriwether breaks down the shocking finale and what’s next for the crime drama: ‘I’m definitely not using the show as a platform to advocate murdering people.’
Microsoft September 2026 Patch Tuesday fixes 966 flaws, 2 zero-days
Today is Microsoft's September 2026 Patch Tuesday, with security updates released for a record-breaking 966 flaws, including two actively exploited zero-day vulnerabilities.
Trinity Health in Livonia to lay off 557 employees starting in October, primarily in IT support
Trinity Health’s Livonia location will permanently lay off 557 employees, largely in its technology and information services division, the Michigan Department of Labor and Economic Opportunity announced recently. Layoffs are scheduled to begin Oct. 25 and continue through Nov. 29, according to a notice published by the department. The layoffs come months after Trinity Health […]
Apple Releases iOS 26.6.2
Apple today released iOS 26.6.2 with a fix for "an issue that prevents downloading a software update over a cellular connection". The minor software update is rolling out now for the iPhone 11 series and newer. To update your iPhone, open the Settings app and tap on General → Software Update. It might take a few minutes until the update is visible to everyone. iOS 26.6.2 arrives approximately three weeks after iOS 26.6.1, which delivered security fixes.
If AI thinks it's conscious, it's more likely to believe in vampires, karma and ghosts, new study shows. What does it mean for how we use it?
A new study shows that measures to stop AI's claims of consciousness have unintended consequences for non-human entities
I found 5 ways to use my Android camera that have nothing to do with photos
I unlocked completely different uses for the camera
Eagles legend Brandon Graham announces retirement after 16 seasons
Brandon Graham announced his retirement for a second time, ending a franchise-record 16-season career spent entirely with the Philadelphia Eagles
Clive Davis’ $35 million art trove, including Warhol and Hockney, heads to auction
The works owned by Clive Davis includes David Hockney's portrait of Andy Warhol and Warhol's portrait of Aretha Franklin, among other works collectively estimated to fetch more than $35 million.
Are rich people really worse behaved? Here’s the science
Who’s more likely to steal sweets from a child? According to science, it’s the rich. A study seemingly confirming our suspicions about the moral behaviour of the wealthy was one of the winners of the 2026 Ig Nobel prizes, which honour research that makes you laugh and then think. Science editor Ian Sample tells Madeleine Finlay what the researchers think could be behind the phenomenon, and they explore some of the other awards, including one for a surprising quality we look for in our friends and another for a biomechanical definition of kissing
Clive Davis’ art collection heads to Christie’s auction
Clive Davis’ largely unseen art collection, featuring works by David Hockney and Andy Warhol, could fetch more than $35 million at Christie’s.
Here’s Samsung’s Advice for Apple and Its Upcoming Folding iPhone
The competition is “absolutely welcome” by the pioneering Korean giant, but Samsung warns that the device’s “weight” is crucial.
New-to-science Amazon frog stands out for its slow ‘lazy’ song
Scientists recently described a new species of a tiny brown frog found in the Amazonian floodplain forests of Ecuador and northwestern Brazil. It looks nearly identical to related species but its slow, widely spaced out call sets it apart, researchers note in a study. “I’ve had to get into arguments because people said the frog […]
Week 1 Reminded Us Why College Football Is the Best
College football is officially back. And somehow, Week 1 already gave us enough storylines for an entire season. The biggest statement came from LSU . Lane Kiffin’s debut couldn’t have gone much better, as No. 11 LSU absolutely destroyed Clemson 51-10 in Death Valley. LSU piled up 644 yards while holding Clemson to just 145.…
No Evidence That Sugar Substitutes Harm Weight, Health, or Sweet Taste Preferences
New review of three major EU-funded trials shows swapping sugar for non-nutritive sweeteners may help with weight loss maintenance, while broader "sweet taste" exposure appears largely neutral for health.
Roundup: Energy employment / Small business confidence / Maritime woes
Jobs in transition: Energy sector employment fell about 1% nationwide and in Louisiana from 2024 to 2025, with Louisiana losing 1,131 jobs to reach roughly 160,000 workers. The decline was driven largely by automation, policy changes affecting renewable energy, and shifting economics, while traditional energy industries such as coal and nuclear saw job growth. Despite […]
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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MDI Health to Honor Mount Desert Nursing Association with 2026 Impact Award
BAR HARBOR—MDI Health will honor Mount Desert Nursing Association (MDNA) as its 2026 Community Partner of the Year during the organization’s Annual Meeting and Community Celebration on Tuesday, September 15. MDNA will receive the 2026 Impact Award in recognition of its longstanding commitment to providing in-home nursing, physical and occupational therapy, and medical equipment to the Island region. By caring for people where they live, MDNA helps patients remain safely and independently at home, providing reassurance and support to their families. “Mount Desert Nursing Association exemplifies the power of community partnership,” said Chrissi Maguire, President and CEO of MDI Health. “Its nurses bring skilled, compassionate care directly into people’s homes, helping patients navigate illness, recovery, and some of life’s most difficult moments. We are deeply grateful for MDNA’s service and the important role it plays in the health of our community.” MDNA works closely with MDI Health providers and care teams to support continuity of care following hospitalization, surgery, illness, or changes in health. Its personalized services extend care beyond the hospital and help ensure patients receive the support they need close to home. “For 77 years, MDNA has been here for our community, helping our neighbors recover and remain safely at home. Our long-standing partnership with MDI Health is an important part of making that possible. Together, we help ensure a seamless transition from hospital to home and provide patients with the continued care they need. We are incredibly grateful for this recognition and especially proud of our talented and hardworking team,” said Amy McVety, Executive Director of Mount Desert Nursing Association. The Impact Award will be presented during MDI Health’s Community Celebration from 5 to 7 p.m. at the Bar Harbor Club. The event will also recognize outstanding employees, volunteers, and trustees; celebrate MDI Health’s achievements over the past year; and mark a transition in Board leadership as Madeleine Braun, PhD, MBA, prepares to succeed Martha Wagner, PhD, as chair. The celebration will feature music, refreshments, the MDI Health Auxiliary Raffle, and a cash bar. MDI Health’s Annual Business Meeting will take place from 3:30 to 4 p.m. via Zoom. These events are free and open to the public, but space is limited. To reserve your spot, contact Patrianna Anderson at 207-288-5082, ext. 1432, or visit mdihospital.org/communitycelebration. Subscribe Share Leave a comment
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