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Asher Grunis steps down from leading Submarine Affair commission due to health concerns
Supreme Court President Isaac Amit appointed retired Supreme Court justice Zvi Zylbertal to replace Grunis and lead the commission on Sunday.
After arts festival, San Francisco's Mid-Market businesses look for signs of a turnaround
How to watch the 2026 WNBA Finals: Golden State Valkyries vs. Atlanta Dream Game 5 time, schedule, where to stream and more
Gina Hinojosa says there's "deep disappointment in both political parties" in Texas right now
Cracking a smile regularly may be good not just for your mood but for your health
Reminding yourself to smile often can not only help you form more friendships but also make you feel better.
‘I love spending time with them’: Lewis Hamilton opens up about Kim Kardashian’s kids
Lewis Hamilton and Kim Kardashian have been one of the most talked-about couples in sports and entertainment this year, but the seven-time Formula 1 world champion has rarely said much about the relat...
Cracking a smile regularly may be good not just for your mood but for your health
Reminding yourself to smile often can not only make more friendships but it can also make you feel better.
Trump on high gas prices: 'We're making a freaking fortune"
Americans, meanwhile, are paying record prices at the pump, according to AAA.
Navigating D1 pressure: how student-athletes balance their mental health
Mental health affects everyone, including athletes who have a really good way of hiding it. Research shows that mental health issues affect roughly 39-44% of Division I athletes. Behind game day, good game performance, and navigating life in college, D1 athletes are constantly trying to balance high expectations with their own well-being. It’s not...
Unpatched Tailscale SSH Flaws Could Let a Hacked Device Reach Root on Other Servers
Unpatched Tailscale SSH flaws could let attackers gain root on permitted servers from a compromised device when port forwarding is enabled.
Schefter: Seahawks among teams ‘expected to consider’ Jonathan Taylor trade
The Seahawks are “pondering” adding Taylor in hopes of saving their run game.
Scientists Discover How Excess RNA Can Disrupt the Energy Supply Inside Cells
Scientists at Texas A&M University discovered that excess RNA can interfere with the machinery cells use to produce energy, even without triggering certain immune defenses. The findings reveal an unex...
‘You Can See Everything’ surges with $19.5M at box office; ‘Clayface’ takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KCBS All News 106.9FM and 740AM
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KNSS Radio
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KMBZ
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1
NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...
What are you reading this week?
Our reading list never stops growing, but this week we're digging into buzzy literary thriller Fruit Fly and a sweet paranormal romance.
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race
Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race
Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.
Cattle Science Gets a $19.5 Million Upgrade as West Texas A and M Plans High-Tech Research Complex
West Texas A&M is building a $19.5M cattle research complex featuring AI technology, veterinary research and commercial-scale feedlot studies.
Police: Lancaster County health care worker assaulted
Incident occurred at WellSpan Hospital in Ephrata Borough, according to police.
Epic CEO Tim Sweeney lambasts “abhorrent” Steam AI Disclosure Policy claiming labels double as “political statement”
Epic Games CEO Tim Sweeney called Steam’s AI disclosure policy abhorrent, arguing that it exposes developers to backlash from anti-AI detractors. Valve has implemented and updated the policy since 2024, which states that AI-generated content, including artwork, text, music, and assets, excluding assistant tools, requires formal disclosure.
Warriors honor Bay Area sports reporter Michael Wagaman
After Michael Wagaman passed away in early August, Dallas Braden took time to tribute him during his call of the Athletics’ game on NBC Sports Bay Area and California. Wagaman had covered Bay Area sports teams since 1996, including for the Associated Press, and freelanced for NBC Sports Bay Area and California at the time…
Lakers 1st-Round Draft Pick Floated as Trade Piece
The Los Angeles Lakers are off to a fast start. Could it be time to weigh trading away some young pieces to boost the rotation? The post Lakers 1st-Round Draft Pick Floated as Trade Piece appeared first on HEAVY.
Lycia Lands a $317M IPO for Inflammation Drugs Based on Nobel Prize-Winning Science
Lycia Therapeutics’ protein-degrading drugs are based on the research of Carolyn Bertozzi, a Stanford chemistry professor and Nobel laureate. Lycia’s lead drug candidate is in development for food allergy, where it could compete against the blockbuster Roche drug Xolair.
MTSU named among Billboard's Top Music Business Schools for 12th year in a row
Middle Tennessee State University has been named a top music business school by Billboard for the 12th year in a row.MTSU's Department of Recording Industry mad
2 political experts question Chicago Mayor Brandon Johnson's tax proposals for 2027 budget
AI coding agents hijacked using AGENTS.md file in Downloads folder
Researchers found a malicious AGENTS markdown instruction file in a customer's Downloads folder that tricked an AI coding agent into installing a rogue npm package.
Cost of employer-sponsored health insurance rises again, survey finds
WASHINGTON — The cost of employer-sponsored health insurance increased again this year, as did the deductibles many people must pay before their plans begin covering most health care expenses, according
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Timeline of the Capitol Annex project
Ashley Zavala looked back at the decade-long process of building the new offices for the governor and state lawmakers.
South Texas Health System (@stxhealthsystem)
1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".
Google's next TV gadget may do much more than stream
A reported hardware overhaul could bring Gemini further into the living room.
Syria’s Democratic Transition: Building Institutions Alongside Political Competition
Syria’s post-Assad transition has revived debate over when to legalize political parties. Parties are essential to political competition,
Rep. Haley Stevens sidesteps whether she still supports El-Sayed, criticizes outreach to Black voters
Scientists Find Chronic Back Pain Activates a Brain Network Linked to Personal Identity
A new UC San Diego brain imaging study involving 114 adults suggests that chronic back pain flare-ups affect brain networks involved in self-reflection and personal memories. The findings may help exp...
University of Rochester Medicine Home Healthcare holds inaugural Hospice 5K
13WHAM ABC Rochester provides local news, weather forecasts, traffic updates, health reports, notices of events and items of interest in the community, local sports and entertainment programming for Rochester and nearby towns and communities including Greece, Victor, Pittsford, Penfield, Henrietta, Webster, Irondequoit, Fairport, Chili, Gates, Rush, Wheatland, Canandaigua, Farmington, Spencerport and Hilton.
Grading Iowa Football's Loss To Minnesota
This may have been Iowa's worst quarterback performance since the dreadful 2023 season.
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say
A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…
Preview
The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...
LETTER TO THE EDITOR: Misleading political mailer is a smear campaign
The recent misleading smear mailer by the opponents of Denise Krause in the Oregon Senate campaign is the most disgusting exhibit of money and indecency used to capture uninformed voters’ […]
Manchester United vs Bournemouth: Live updates from Old Trafford
Under-fire Manchester United manager Michael Carrick is under enormous pressure heading into today’s Premier League clash with Bournemouth on the back of a seven-game run without a win.The boss has ...
Science Snapshots: October 25, 2026
Three key science updates in one minute: Starry Night’s dawn matched to Jul 22, 1889; cold boosts lifespan via BH2/BH4; cluster similar-buildings cools cities.
Argument over purchase turns physical; suspect pulls gun at South Side business
KABB Fox News 29 San Antonio provides local news, weather forecasts, traffic updates, investigations, notices of events and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Bandera, Boerne, Carrizo Springs, Castroville, Cibolo, Converse, Crystal City, Cuero, Del Rio, Devine, Eagle Pass, Floresville, Fredericksburg, Goliad, Helotes, Hondo, Kerrville, Live Oak, New Braunfels, Pearsall, Pleasanton, Poteet, Poth, Sabinal, San Marcos, Seguin, Schertz, Somerset, Universal City, Uvalde, Windcrest.
Argument over purchase turns physical; suspect pulls gun at South Side business
WOAI NBC News Channel 4 San Antonio provides local news, weather forecasts, traffic updates, investigations, and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Windcrest, Uvalde, Universal City, Somerset, Seguin, Schertz, San Marcos, Sabinal, Poth, Poteet, Pleasanton, Pearsall, New Braunfels, Live Oak, Kerrville, Hondo, Helotes, Goliad, Fredericksburg, Floresville, Eagle Pass, Devine, Del Rio, Cuero, Crystal City, Converse, Cibolo, Castroville, Carrizo Springs, Boerne, Bandera.
Week 7 Early Games Open Thread
The only games I’m really keyed in on are the Steelers and Texans both losing to the NFC team and then decided which team between the Bengals and Ravens are the bigger threat to Denver’s future playoff seeding arrangement. Here are the games we have to watch today before the Denver Broncos take on the […]
Colts vs. Vikings
Here is how the ColtsRoundtable staff sees the Week 7 matchup between the Indianapolis Colts and Minnesota Vikings unfolding.
Will there be VAR for Fleetwood Town vs Arsenal?
The EFL have confirmed the match official appointments for the upcoming round of League Cup fixtures, including Arsenal’s trip away to Fleetwood Town.Photo by George Wood/Getty ImagesThe EFL have co...
DOE expands tribal energy funding to $125M, selects 63 projects
The Department of Energy expanded a $50 million tribal energy funding opportunity to more than $125 million after tribal applications sought roughly 10 times the initial amount. The agency selected 63 tribe-led projects across 16 states for what it described as the largest single investment in the Office of Indian Energy’s history. The projects include […]
Guardians Middle Infielder is a Prime Trade Candidate
The Cleveland Guardians, fresh off an ALCS appearance, will be facing several tough decisions next season regarding their lineup. The 85-win team won their division and looks poised to repeat next year, but they face an enviable dilemma. What do they do with their influx of top, young talent, and how do they find them …
A last-minute voter guide to all 14 propositions on the California ballot
Californians are voting on 14 ballot measures, including propositions on taxes, voting, healthcare, housing and the environment. It's a lot to take in, but we're here to help.
After win over Ole Miss, Texas QB Arch Manning says that he 'kind of likes being disregarded'
6 Tech Brands Owned By Best Buy
Best Buy owns several tech brands, including Insignia, Rocketfish, and Best Buy Essentials, that offer competitive performance and value.
I Tried TikTok’s Viral Pea Salad to ‘Fibermaxx’ My Lunch—and It Didn’t Quite Go According to Plan
There can be too much of a good thing, as my gut found out firsthand.
What analysts are watching in the Texas Senate race, CBS News political experts weigh in
Seamus Power, Austin Smotherman Share Lead In Windy Bermuda Showdown
Seamus Power and Austin Smotherman share the Bermuda Championship lead at 16 under, with fierce winds and PGA Tour playing privileges adding drama to Sunday's finale.
Utah Jazz Must Let Darryn Peterson Feel the Pressure
Shielding Utah’s prized rookie from high-stakes moments only stunts his growth. To secure their future, the Jazz must force Darryn Peterson to embrace the game-deciding pressure now.
A simple liquid can stop cavities without drilling, major study confirms
A simple liquid painted onto teeth in seconds can stop cavities without drilling, injections, or anesthesia, according to a major clinical trial involving young children. The inexpensive treatment could spare thousands of children painful dental procedures and surgery while paving the way for broader FDA-approved use.
Building bridges that lift us above hate
When Mohammed Al Samawi was growing up in Yemen, the son of a pair of middle-class doctors, teachers taught him that Jews and Christians were enemies destined for hell. “We were trained as children to hate,” he told an audience of some 450 at an antisemitism conference in Denver last week. Like many of his […]
Scientists reveal the hidden danger of missing blood pressure medication
Missing blood pressure medication could mean losing much of its protection against heart attacks and strokes, according to an analysis of more than 91,000 people. Patients who consistently took their medication experienced an 11% reduction in major cardiovascular events, while those who missed too many doses saw little or no measurable benefit.
Just two drinks a day may be far riskier than you think
A major new study reveals that drinking just two alcoholic beverages a day is associated with a 1 in 25 lifetime risk of death from alcohol-related causes, challenging the idea that moderate drinking is harmless. Researchers also found no significant overall health benefits from alcohol, with risks rising as consumption increases.
Three giant black holes discovered in a galaxy from the dawn of time
Astronomers have discovered three actively feeding black holes inside a single galaxy more than 12.5 billion light-years away, revealing a remarkable scene from the universe’s infancy. Two of the black holes are separated by just 620 light-years and are expected to eventually merge, while a third lurks farther away. One weighs an astonishing 80 million suns, and another is growing faster than conventional theories predict.
Just two drinks a day may be far riskier than you think
A major new study reveals that drinking just two alcoholic beverages a day is associated with a 1 in 25 lifetime risk of death from alcohol-related causes, challenging the idea that moderate drinking is harmless. Researchers also found no significant overall health benefits from alcohol, with risks rising as consumption increases.
Five new businesses coming to Hunt Valley Exchange, including Dunkin’ and indoor golf simulator
Five businesses are coming to Hunt Valley Exchange in northern Baltimore County, including a Dunkin’, indoor golf simulator studio, Indian restaurant and wine and spirits store.
US employer health insurance premiums exceed $28,000 for family coverage in 2026
US employer health insurance premiums rose 5% in 2026, exceeding $28,000 for family coverage, while nearly half of working-age adults lack adequate coverage
Svilar eyes return from injury vs Manchester United
Gian Piero Gasperini can hope for a return to goal for his regular starter before the new international break. According to Riccardo Trevisani on Radio Manà Manà Sport Roma, Mile Svilar could recove...
Knoebels’ Hallo-Fun brings Halloween rides, treats and entertainment
FOX56 WOLF TV carries news, sports, weather and coverage of local events in the Wilkes-Barre, Pennsylvania area, including Mountain Top, Plymouth, Nanticoke, Kingston, Back Mountain, Scranton, Moosic, Pittston, Avoca, Edwardsville, Hilldale, Wyoming, Laflin, Yatesville, Pittston, Dupont, Sugar Notch, Korn Krest, Warrior Run and Larksville.
Amorim eyes raid on Manchester United for £52m defender
Ruben Amorim is keen on a reunion with Manchester United defender Leny Yoro at AC Milan.The Serie A side are weighing up a move for the 20-year-old at the end of the season, according to reports in It...
Sunday Night Football: How to watch the Kansas City Chiefs vs. Seattle Seahawks game tonight
Updated SEC football conference standings following Week 8 upsets
The SEC's Week 8 slate produced a number of notable results. Here is how those results impacted the conference standings entering Week 9.
Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links
Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links Unfair Links Launches a Link Building Service for Local Backlinks and Google Business Profile Matched Links New York City, USA, Oct. 25, 2026 (GLOBE NEWSWIRE) -- Founded by Rollo Unden and Oliver Fish, Unfair Links builds local backlinks matched to a business's Google Business Profile, country and language, and is now taking sign-ups for its beta waitlist. Unfair Links, a new link building
CEO SUNDAY: Atomic Wings CEO shares his journey from Wall Street to the restaurant business
Atomic Wings CEO Zak Omar shares how his father’s influence, a leukemia diagnosis and a commitment to customer service shaped his path to building a 35-location restaurant chain.
CBS News political experts weigh in on Texas Senate race halfway through early voting
The latest CBS News poll showed Talarico leading 51% to 49%, well within the margin for error.
New York Giants' Never-Ending Nightmare Might Get Even Worse
Things just keep getting worse for the New York Giants.
Paris Pressure: Saints Must Block Out the Chaos and Finish Their Business Against the Steelers
Woman Is Quoted $2K to Put Up a Flex Wall in N.Y.C. Apartment, So She Uses Plastic Building Blocks Instead (Exclusive)
“I really grew to love my little castle,” Alliyah Barre tells PEOPLE