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Eupora police seize THC vapes, kratom in business raids
Eupora police served search warrants on two businesses Friday after reports that the businesses were selling illegal THC vapes, kratom and other controlled substances.
Official White House website launches arcade games where users arrest immigrants and build a border wall
The Trump administration launched a series of arcade-style games on the official White House website Thursday to tout its priorities — the latest turn in its aggressive online effort to troll Democrats that has at times surfaced racist and offensive images.
Antarctic expedition reveals why Southern Ocean clouds remain one of climate science's greatest challenges
The Southern Ocean plays a pivotal role in regulating Earth's climate, yet the clouds that blanket this remote region remain among the least understood features in atmospheric science. By controlling ...
Pre-Orders For Sony's GTA 6-Themed DualSense Controllers Will Open On September 10
At $85, the hardware only costs a little bit more than the game.
Grand Theft Auto 6 Is Getting a Pair of Limited Edition PS5 Controllers
Rockstar Games and PlayStation have revealed a pair of GTA 6-themed PS5 controllers.
GTA 6 is getting two custom PS5 DualSense controllers
Both GTA 6 PS5 controllers will be available via PlayStation Direct…
"This is the worst crash we've seen since the 1980s," says Tim Sweeney
Industry experts speak to Edge Magazine deputy editor Alex Spencer about how the industry is facing "Crash 2.0"
What Happens When AI Starts Doing Business with AI?
As AI agents increasingly interact with one another on commercial platforms, firms need new rules governing what those agents can see, decide, and do. In a controlled AI-to-AI simulation covering 160 governance runs and 2,560 observations, researchers tested four governance mechanisms: information disclosure, agent autonomy, reputation signals, and structured interaction protocols. Rich, machine-readable information helped agents identify promising counterparties, while greater autonomy improved their ability to move opportunities toward commitment. Reputation signals helped agents determine which opportunities deserved attention. Rigid interaction protocols, however, reduced engagement and exchange progression. The findings suggest that firms should establish clear levels of agent authority, run bounded experiments, provide structured information and reputation signals, and design explicit handoffs from agents to human decision-makers.
CIAA ANNOUNCES STRATEGIC MEDIA RIGHTS PARTNERSHIP WITH URBAN EDGE NETWORK AND VAN WAGNER
CHARLOTTE, N.C. — [September 2, 2026] — The Central Intercollegiate Athletic Association (CIAA®), Urban Edge Network LLC (UEN) and Van Wagner Sports and Entertainment (VWSE) today announced a strategic media rights partnership that will expand the distribution and visibility of CIAA athletics while creating new opportunities to grow audiences, generate revenue and strengthen the long-term value of CIAA controlled content.
“Ruined Mike Trout’s Entire Career” – Fans React After Angels Star Gives Verdict on Arte Moreno’s $4 Billion Sale To Rams Owner
Three-time AL MVP Mike Trout sounded optimistic about the Angels’ ownership changing hands in a reported deal worth $4 billion. Kroenke Sports and Entertainment has a deal in principle to purchase a controlling majority stake in the ballclub from Arte Moreno.
The science of emotional regulation — and how to do it better
Do you ever feel like your emotions control you instead of you controlling them? Maybe you lash out at someone after a long day at work or indulge to avoid a stressful situation. It’s called emotional dysregulation and don’t worry – we all experience it at some point. Luckily, there’s a better way of dealing with our feelings: building emotional intelligence. That may seem daunting, but Short Wave is here to guide you through everything from understanding the importance of emotions to how we can repair our relationship to them.Interested in learning more about your brain and your feelings? Email us your question at shortwave@npr.org. We might cover it in a future episode!Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. It includes perks like bonus episodes, early access, archive access, curated playlists and sponsor-free listening. Learn more at plus.npr.org.
The US trade war strategy is to troll Canada
Canadian Prime Minister Mark Carney, who walked away from US trade talks last week due to what he said was American intransigence, now wants to get negotiations started again.
Stan Kroenke buys controlling stake in MLB's Los Angeles Angels
Kroenke Sports and Entertainment was valued at more than $26 billion in CNBC's most recent list of the world's most valuable sports empire.
LA Rams owner Kroenke reaches agreement to buy Angels
Kroenke Sports & Entertainment ("KSE") today announced that it has entered into a definitive agreement to acquire a controlling interest in the Los Angeles Angels Baseball Club from the Moreno family. The transaction is expected to close in the first quarter of 2027, subject to customary closing conditions and approval
Kroenke to buy controlling interest in Angels from Moreno
Stan Kroenke has reached an agreement to acquire controlling interest in the Los Angeles Angels from Arte Moreno.
Kroenke Sports & Entertainment announces agreement to buy Angels
Kroenke Sports & Entertainment announced Tuesday that it has entered into an agreement to acquire a controlling interest in the Los Angeles Angels. In a news release issued Tuesday, the ownership group said the deal with the Moreno family is expected to close early next year. The transaction would require approval from Major League Baseball. The Kroenke-affiliated group also owns…
Kroenke Sports & Entertainment announces agreement to buy Angels
Kroenke Sports & Entertainment announced Tuesday that it has entered into an agreement to acquire a controlling interest in the Los Angeles Angels. In a news release issued Tuesday, the ownership group said the deal with the Moreno family is expected to close early next year. The transaction would require approval from Major League Baseball. The Kroenke-affiliated group also owns…
Onondaga County Legislature unanimously approves deal on term limits
The 15-0 vote means two term limit options for the county executive and comptroller could be headed to voters.
Razer Unveils the Razer Prio: the Pocket-Sized Controller
Razer, the leading global lifestyle brand for gamers, today announced the Razer Prio, an ultra-mobile, foldable USB-C gaming controller engineered for iPhone and Android. Built to turn daily downtime, from commuting delays to breaks between classes, into console-grade gaming sessions, the Prio...
Settle In and Get Comfortable with the Designed for XBOX Cozy Collection
Made for side quests, little adventures, and everything in between, the Designed for XBOX Cozy Collection is available now, bringing warmth and whimsy to every journey. Step into a tiny, pixelated woodland where every click, key stroke, and button tap feels like discovering a new cozy corner. The 8BitDo keyboard, mouse, and controller bring a […]
Homey just made the smart home controller I hoped Apple would build
A portal to a smarter home?
Razer Just Released A Cute And Teensy Mobile Game Controller
It's called Prio and folds up when not in use, making it pocket-friendly.
Top Science Journal: All Scientists Should Register With the State
It would be a means of controlling who is allowed to “do” science and the ability to determine what can be communicated to the public.
Razer Prio is an Android and iPhone game controller that folds down to roughly the size of a credit card
Razer has just launched its new Prio game controller, a USB-C controller for your smartphone that folds down to the...
GTA 6 Removes The Series' Worst Feature
Out-run the cops without breaking your controller.
Kroenke Sports & Entertainment to Acquire the Los Angeles Angels of Anaheim
Kroenke Sports & Entertainment ("KSE") today announced that it has entered into a definitive agreement to acquire a controlling interest in the Los Angeles Angels Baseball Club from the Moreno family. The transaction is expected to clos
US oil firm to take over some Venezuelan oilfields previously run by Chinese, Russian companies, officials say
U.S. oil company North American Blue Energy Partners will take over some oilfields previously controlled by five Chinese companies and a Russian firm, two U.S. officials told Reuters on Monday.
OOI Participates in Woods Hole Science Stroll
The Woods Hole Science Stroll is an annual event that highlights the major research institutions located in Woods Hole village (WHOI, MBL, NOAA, USGS, USCG), and also includes over 20 organizations representing a breadth of STEM research, education, and environmental groups (Fig 1). The all-day event is open to the…
Apple Reportedly Considered Going Full Palm Pilot With Its Foldable iPhone
Steve Jobs did not want the iPhone to be controlled with a stylus.
Philippines’ richest billionaire agrees to buy African port operator spanning three countries
Enrique Razon-controlled ICTSI has agreed to acquire an African port operator with businesses in South Africa, Mozambique and Namibia
USC Gets Brutally Trolled Amid NDSU’s FBS Debut
USC once had NDSU has a potential option for Week Zero, and how things turned out on Saturday was ironic in hindsight. The post USC Gets Brutally Trolled Amid NDSU’s FBS Debut appeared first on HEAVY.
Opinion: Alaska’s science is strange enough without the conspiracy theories
Alaska’s research facilities do remarkable work. Causing earthquakes and controlling the weather isn’t part of the job description.
TEMPEST collaboration will take on turbulence
Yale is part of a new, multi-institution research center focused on understanding and controlling turbulence — one of the oldest unsolved problems in physics.
Android 17 Adds OS-Wide ECH to Hide Website Visits From Network Providers
Android 17 adds OS-wide ECH, local network permissions, default certificate transparency, and carrier-controlled 2G blocking.
What video games say about Cleveland sports
Cleveland's best championship odds might currently involve a controller.
FDA announces recall of all Impella heart pump controllers after 3 deaths
Johnson & Johnson MedTech is recalling all of its Automated Impella Controllers due to an ongoing safety issue linked to 37 serious injuries. Care teams can still use these devices as they await a replacement.
Preorders Are Live for the Xbox Wireless Controller X25 Special Edition – It Costs $79.99 and Is Out October 20
You can now preorder the Xbox Wireless Controller X25 Special Edition from a variety of retailers.
Xbox Series X25 Console & Controller: Prices, Release Dates, Pre-Orders Announced
Official confirmation!
How Ikea Turned a Controller Thumbstick Into the Star of Its Xbox Gaming Range
Xbox and Ikea collab alert! This unique nine-piece collection for gamers arrives this fall and has a slew of Easter eggs.
Here Are Three Sick Gibson Guitar Controllers Made For Stage Tour's Dec. 10 Release
CRKD is mining nostalgia for its latest guitar trio.
Take a look at Microsoft’s new 25th anniversary Halo accessories
A mouse, keyboard, earbuds, and controllers in “OG Green.”
Nemesis Brad Marchand Trolls Maple Leafs Star On Social Media
There are few players in the National Hockey League who have been as big a thorn in the side of the Toronto Maple Leafs over the last several seasons than Brad Marchand.Marchand, who has played for the divisional rival Boston Bruins and Florida Panthers, has been one of the most instrumental players for both teams […] The post Nemesis Brad Marchand Trolls Maple Leafs Star On Social Media appeared first on HEAVY.
Eastlake science students make district history
Three Eastlake High School students made Sweetwater Union High School District history this year when they became the first students from the district to qualify for the International Science and Engineering Fair, an international competition that brings together some of the top high school researchers from around the world. Ronald Wyatt, Giles Del Priore and Ihan Sung advanced to the competition after successful runs at regional and state science fairs. Sung went a step further, placing fourth in the chemistry category at ISEF. The students were recognized on Aug. 10 during a Sweetwater Union High School District board meeting at the district office in Chula Vista.For Wyatt and Del Priore, recent Eastlake graduates, the journey began with a shared concern about dementia and the challenges faced by families caring for loved ones with memory impairment. Their engineering project, “Design and Evaluation of a Behaviorally Grounded Caregiver-Governed AI Companion for Individuals with Memory Impairment,” earned the Sweepstakes Award at the Sweetwater District STEM Fair and first place in its division at the Greater San Diego Science and Engineering Fair. The project explored whether Artificial Intelligence could provide companionship and support while helping reduce stress for people with dementia and their caregivers. “Our inspiration came from personal experience. Both of us have seen family members and loved ones affected by dementia, and we’ve witnessed how overwhelming the caregiving process can be,” Wyatt said. Del Priore said the students also wanted to address the high cost of third-party health care services while creating something that could potentially help their own families as well as people elsewhere. The students developed an AI system designed with safeguards intended to prevent misinformation reinforcement, emotional escalation and unsafe responses. In 240 controlled trials involving memory, identity, agitation and neutral scenarios, they said the system consistently prevented harmful incorrect reinforcement while using context-aware silence, de-escalation and caregiver verification. The project required the students to combine Artificial Intelligence, psychology, neuroscience and human-computer interaction. For Del Priore, one of the biggest technical challenges was getting the AI companion to communicate verbally with a patient. Hardware limitations required the students to collaborate with multiple Python libraries for speech-to-text and text-to-speech functions while keeping the cost of the companion low. “For us, the biggest challenge was translating complex behavioral and cognitive care principles into a functioning AI system,” Wyatt said.Qualifying for ISEF was a milestone that student expected. The international competition proved to be another milestone. “Competing at ISEF was an incredible experience and unlike anything we’ve ever done before,” Del Priore said. “Being surrounded by some of the most talented young researchers from around the world was both inspiring and motivating.” He said the experience stood out because of the emphasis on collaboration, innovation and scientific discovery. “The most memorable part was seeing how people from completely different backgrounds and disciplines approached solving real-world problems with creativity and passion,” he said. The students also credited teachers and mentors who supported their work. Del Priore said his sophomore-year AP Physics teacher, Dr. Price, was particularly influential. “Through all of my personal and academic struggles, Dr. Price always believed in me,” Del Priore said. “All of his faith in me really molded me into the person I am today and helped create my love for science even through tough times.” Wyatt is continuing his education at UC Santa Cruz, where he plans to study biomolecular engineering and bioinformatics, with an interest in research involving Artificial Intelligence, biology and health care. Del Priore plans to double major in chemistry and accounting. Sung, a rising Eastlake senior, qualified for ISEF after winning first place in the Engineering: Energy, Materials & Transport category at the Greater San Diego Science and Engineering Fair and first place in chemistry at the California Science and Engineering Fair. His project, “Renewable Ammonia Electrochemical Synthesis by Glow Discharge with an Iron-Based Catalyst,” involved a device he designed and engineered to produce renewable ammonia, with potential applications in fertilizer production and energy storage. Sung became interested in the project after considering the relationship between food insecurity and fertilizer costs. His system uses plasma to break apart nitrogen molecules so they can interact with hydrogen and form ammonia. At ISEF, Sung competed against more than 1,700 students from 65 countries and earned fourth place in chemistry. “I am proud to become one of te first students in the district to qualify for ISEF because this milestone can inspire others in the district to attain similar goals,” Sung said.
WHO RUNS MARYLAND POLITICS NOW?
ByThe Maryland Wire The Machine Didn’t Die — It Broke Apart Mike Miller is gone. Steny Hoyer is retiring. The two men who helped define Maryland political power for generations are disappearing from the map. Nobody has inherited all of what they controlled. Instead, Maryland power has fractured among Wes Moore, legislative leaders, county organizations, federal figures and a new generation fighting to connect the pieces. By The Maryland Wire For decades, there were two names in Maryland politics that required almost no explanation. Mike Miller. Steny Hoyer. You didn’t necessarily have to agree with them. You didn’t even have to like them. But everyone understood something: Not social-media power. Not cable-news power. Not the temporary power that comes from one big election. They possessed political infrastructure. Relationships. Institutional memory. Donors. Staff. Allies. County leaders. Lobbyists. Legislators. Operatives. And the ability to connect people who needed something with people capable of delivering it. Today one is gone. The other is preparing to leave Congress after more than four decades. And Maryland faces a question it hasn’t had to answer in generations: The answer may be: Nobody. At least not the way Miller once did. Maryland’s old machine wasn’t inherited by one person. It fragmented. And now several ambitious political networks are competing to assemble the pieces. Miller presided over the Maryland Senate for 33 years, becoming one of the longest-serving legislative leaders in American history. He stepped down as Senate president in 2019 and died in January 2021. (Behavioral and Social Sciences) But Miller’s real power wasn’t the title printed on his door. It was the accumulation of relationships behind it. Miller came from Maryland’s old Democratic organization and developed into an extraordinarily adaptable political operator, retaining authority even as the Senate around him became younger and more liberal. (The Washington Post) He understood something fundamental: politics is information. Who wants what? Who owes whom? Which senator needs help? Which county executive wants something in the budget? Which committee chairman can move a bill? Which lobbyist represents which client? Which candidate should receive support today because that candidate could be a senator ten years from now? Miller knew the answers because he’d spent decades collecting them. Miller’s influence wasn’t confined to elected officials. Former Miller aides became prominent Annapolis lobbyists. Maryland Matters noted figures such as Joseph Bryce and Timothy Perry among the high-profile lobbyists who had once served as top Miller aides. (Maryland Matters) That was one of Miller’s greatest political achievements. He didn’t merely accumulate power around himself. He produced alumni. Staffers became lobbyists. Legislators became committee chairs. Allies became power brokers. And decades of relationships reinforced one another. By the end, Mike Miller wasn’t simply a person. He was an ecosystem. Hoyer’s network was different. Miller’s power was rooted in Annapolis. Hoyer connected Maryland to Washington. He served in the Maryland Senate before winning election to Congress in 1981 and ultimately became one of the longest-serving members of the U.S. House and a longtime No. 2 in House Democratic leadership. In January 2026, Hoyer announced that he would retire rather than seek another term. (The Washington Post) His influence stretched through: Prince George’s County, Southern Maryland, Congress, federal agencies, donors, campaign organizations, and generations of Democratic candidates. And Hoyer had something machine builders value enormously: a succession network. That became obvious almost immediately. When Hoyer announced his retirement, Maryland’s 5th Congressional District exploded with candidates. Twenty-four Democrats entered the race. But when the votes were counted, the winner was Adrian Boafo, Hoyer’s former campaign manager. Boafo wasn’t running without establishment help. He was endorsed by Hoyer. He was endorsed by Governor Wes Moore. And he ultimately won the Democratic nomination. (AP News) In his victory speech, Boafo described the result as voters deciding it was time to “pass the torch to a new generation of leaders.” (AP News) That phrase captures the transition perfectly. Hoyer’s seat isn’t simply being vacated. Parts of his network are being transferred. But they aren’t being transferred to another Steny Hoyer. They’re being absorbed into a newer political constellation. And standing prominently inside that constellation is Wes Moore. If someone forces you to name the single person sitting nearest the center of Maryland Democratic politics today, the answer is Governor Wes Moore. The 2026 Democratic gubernatorial primary underscored the scale of his position. Moore won renomination overwhelmingly, receiving roughly 88% of the Democratic primary vote. (WBAL-TV) But raw votes tell only part of the story. Look at the party infrastructure. The Maryland Democratic Party says Steuart Pittman ran for state party chairman in 2025 “at the suggestion of Governor Wes Moore.” Pittman took office that July. (The Maryland Democratic Party) That’s important. Governors traditionally influence their state parties. But party leadership plus fundraising, endorsements, executive appointments and national relationships creates the beginning of something bigger: a political network that could survive the governor’s term. Moore also played a role in the Hoyer succession by backing Boafo. That’s how political organizations reproduce themselves. You support tomorrow’s politician today. And that’s the distinction that matters. Moore has enormous statewide visibility. Miller had decades of accumulated legislative control. Moore can endorse candidates. Miller could influence the environment in which legislators lived every day. Committee assignments. Leadership positions. Legislative priorities. Relationships that had been accumulating since before many current lawmakers entered politics. Moore may have a larger national profile than Miller ever possessed. But he doesn’t possess Miller’s half-century of Annapolis memory. Nobody does. Which is why the modern Maryland political structure looks less like a pyramid and more like several power centers connected by overlapping relationships. One of those centers belongs to Senate President Bill Ferguson. Ferguson controls an institution no governor can simply command. The Senate. Maryland’s official 2026 legislative records identify Ferguson as Senate President. (Maryland General Assembly) That means influence over: committee structure, Senate leadership, legislative priorities, confirmations, and negotiations with the House and governor. But Ferguson is not Mike Miller 2.0. Miller’s extraordinary longevity allowed him to become almost inseparable from the institution. Ferguson possesses the office. Miller possessed the office plus decades of political mythology and accumulated relationships. Those aren’t the same thing. The House now has its own new center of gravity. Official 2026 legislative records identify Joseline Peña-Melnyk as Speaker of the House of Delegates, alongside Ferguson as Senate President. (Maryland General Assembly) That makes the current Maryland governing triangle: Executive power. Senate power. House power. None fully controls the others. And that fact alone demonstrates how different modern Maryland is from the Miller era. The governor proposes. The legislature disposes. Committee leaders negotiate. County interests intervene. And political coalitions shift issue by issue. That’s not one machine. That’s a networked power structure. Then there’s U.S. Senator Angela Alsobrooks. Her significance isn’t that she is the new Hoyer. She isn’t. Hoyer spent decades constructing his network. Alsobrooks brings something different: Prince George’s County roots, a statewide electoral organization, a United States Senate platform, and relationships with national Democratic leaders. That makes her a critical bridge between Maryland and Washington at precisely the moment Hoyer leaves. Hoyer’s retirement therefore doesn’t necessarily weaken Prince George’s influence. It changes who carries it. Prince George’s itself is undergoing a dramatic generational transition. Official 2026 results show Aisha Braveboy winning the Democratic County Executive primary with 87,944 votes and 73.31% of the vote. (Maryland State Board of Elections) That’s political infrastructure. Prince George’s is one of Maryland’s central Democratic vote engines. A county executive with that level of primary support gains: appointments, budget influence, organizational relationships, donor access, and a platform for cultivating the next generation of political leadership. Braveboy therefore isn’t merely another person on the Maryland power map. She controls a place from which a political organization can be built. Boafo is particularly interesting because he sits almost perfectly at the intersection between the old and new worlds. He worked for Hoyer. Hoyer endorsed him. Moore endorsed him. Then Boafo beat an enormous Democratic field for Hoyer’s seat. (AP News) That doesn’t make him powerful on Hoyer’s scale. He’s just beginning. But it illustrates how power actually transfers: not through a ceremonial handoff, but through endorsements, donors, staff, relationships, and voter confidence. Boafo may become Hoyer’s congressional successor. He will not automatically inherit Hoyer’s 40-plus years of political capital. That part has to be rebuilt. This is the part that often gets overlooked. When a machine breaks apart, power doesn’t only move upward. Some people’s relationships become less valuable. Former Miller aides still know Annapolis. Former Miller allies still possess institutional memory. Veteran lobbyists don’t forget how legislation works. But something fundamental disappeared when Miller did: the common center. The person capable of connecting all of them instantly was gone. That changes the value of a political network. Imagine knowing everybody in Annapolis. Useful. Now imagine the person who introduced many of those people, appointed committee chairs, influenced Senate priorities and understood decades of relationships is simultaneously Senate President. Much more useful. Remove that person and the individual relationships remain. But the system becomes decentralized. First: Bill Ferguson. The Senate’s institutional relationships now run through his leadership rather than Miller’s. Second: the House leadership. With the Miller-Busch generation gone, today’s House leaders are building their own committee chairs, alliances and relationships. Third: Wes Moore. Moore became governor after Miller was gone. That distinction matters. Earlier governors had to operate with Miller sitting across State Circle. Moore entered office during a generational reset. Instead of negotiating with the old machine, he has the opportunity to help build the next network. Fourth: Angela Alsobrooks and the emerging Prince George’s generation. Hoyer is leaving. Miller is gone. The county’s political leadership now belongs to another generation. Fifth: politicians who were outside the old Miller organization. When someone dominates an institution for 33 years, inevitably some politicians develop within that organization and others outside it. Miller’s departure created room for people who may never have risen as quickly under the old structure. That’s the biggest point. If Mike Miller’s power had simply transferred to Bill Ferguson, Maryland would still have a machine. If Hoyer’s influence simply transferred to Boafo, Maryland would still have a machine. If every county leader simply took orders from Moore, Maryland would have a machine. None of those things happened. Instead: Moore controls the statewide executive platform. Ferguson controls the Senate. Peña-Melnyk controls the House. Alsobrooks has statewide and federal reach. Braveboy has Prince George’s executive power. Pittman leads the state Democratic Party after Moore encouraged him to seek the role. (The Maryland Democratic Party) Boafo represents the beginning of the post-Hoyer congressional generation. And Baltimore, Montgomery County, organized labor, donors and other county organizations maintain their own centers of influence. That’s not one machine. If you want to understand where Maryland power is moving, don’t simply watch office titles. Watch endorsements. Who does Moore support? Who does Alsobrooks support? Who gets Ferguson’s allies? Who gets House leadership? Who gets Hoyer’s blessing? Who gets labor? Who gets major donors? And most importantly: That is where the new Maryland network becomes visible. The Boafo race was a textbook example. Hoyer’s successor didn’t emerge randomly from 24 candidates. He had ties to the outgoing incumbent and support from the governor. The old network and the emerging one overlapped. And voters chose him. (AP News) Moore may ultimately become the most important person in determining whether Maryland develops another durable statewide political organization. But the test isn’t whether Moore himself remains popular. The test is what happens to the people he supports. Which delegates become senators? Which senators become committee chairs? Which county officials become executives? Which staffers become candidates? Which appointees become statewide leaders? Who gets his donor network? Who gets his political advisers? Who eventually gets his endorsement when Maryland faces a post-Moore gubernatorial succession fight? That’s how we’ll know whether Moore was merely a successful governor— or the founder of another generation of Maryland power. There’s another category worth watching: politicians who came from Miller’s Maryland but remain active in the new one. Dereck Davis is one. Anthony Brown is another. Veteran legislators and former officials throughout the state still possess old relationships that newer politicians don’t. These people can function as bridges. That’s important because political systems rarely reset completely. The new machine usually grows partly from pieces of the old one. Donors don’t disappear. Lobbyists don’t disappear. Operatives don’t disappear. Institutional memory doesn’t disappear. They find new centers of gravity. If you want one name: His overwhelming 2026 Democratic renomination, executive authority, national profile and influence within the Maryland Democratic Party make that difficult to dispute. (WBAL-TV) But saying Moore “runs Maryland” the way Miller once ran the Senate would oversimplify the reality. Maryland power today looks more like this: WES MOORE Statewide organization.Appointments.Fundraising.Executive government.National Democratic relationships. BILL FERGUSON The Senate.Committees.Confirmations.Legislative leverage. JOSELINE PEÑA-MELNYK The House.Committee leadership.Budget and legislative leverage. ANGELA ALSOBROOKS Statewide electoral organization.Federal platform.Prince George’s relationships.National Democratic connections. AISHA BRAVEBOY Prince George’s executive organization.County government.A major Democratic vote base. THE POST-HOYER GENERATION Boafo and the emerging political class that will have to rebuild Hoyer’s Washington-Maryland network rather than simply inherit it. It did something more interesting. Mike Miller’s influence was too personal, too old and too deeply rooted in his own relationships to be inherited whole. Hoyer’s network is too extensive and too intertwined with decades of congressional politics to fit neatly inside one successor. So the pieces are moving. Toward Moore. Toward Ferguson. Toward Peña-Melnyk. Toward Alsobrooks. Toward Braveboy. Toward younger candidates and new county organizations. And toward veteran political survivors who understand both eras. That’s the next chapter of Maryland politics. The person who eventually connects: Annapolis, Prince George’s, Montgomery County, Baltimore, labor, business, donors, the Maryland Democratic Party, and the congressional delegation will possess something Maryland hasn’t truly seen since Miller’s heyday. Not merely another elected official. And maybe that’s why searching for “the next Mike Miller” is the wrong exercise. There may never be another one. The more important question is: Miller spent half a century becoming that person. Hoyer spent decades becoming another version of it. Maryland’s current political leaders are still competing for the privilege. And until somebody actually connects all those pieces, the most accurate answer to the question “Who runs Maryland?” may be the most fascinating one of all: No one does. Not anymore. But there are plenty of people trying. Sources University of Maryland and Maryland Matters — Miller’s 33-year Senate presidency and political legacy. (Behavioral and Social Sciences) Washington Post historical reporting — Miller’s rise from Maryland machine politics and ability to retain power as the Senate evolved. (The Washington Post) Maryland Matters — former top Miller aides who moved into Annapolis lobbying and the changing Senate power structure. (Maryland Matters) Washington Post and Reuters — Hoyer’s January 2026 retirement announcement after more than four decades in Congress and his long Democratic leadership career. (The Washington Post) Associated Press — Adrian Boafo’s 2026 victory in the Democratic primary to succeed Hoyer, including Hoyer and Moore’s support and Boafo’s “pass the torch” remarks. (AP News) Maryland Democratic Party — Steuart Pittman’s official biography stating that he sought the state chairmanship at Moore’s suggestion. (The Maryland Democratic Party) Maryland General Assembly — official 2026 records identifying Bill Ferguson as Senate President and Joseline Peña-Melnyk as Speaker. (Maryland General Assembly) Maryland State Board of Elections — official 2026 Prince George’s County results showing Aisha Braveboy’s dominant County Executive primary victory. (Maryland State Board of Elections) 2026 election reporting — Moore’s overwhelming Democratic gubernatorial primary victory. (WBAL-TV)
Why Are Scientists Creating Cyborg Insect Armies? The Truth Will Surprise You - Futura-Sciences
From Cold War Fantasies to High-Tech Insect Swarms The idea of controlling swarms of insects is far from new. Back in the 20th century, researchers explored ways to use insects for military applications, especially during the Cold War. These flying and crawling creatures were considered as potential vehicles for espionage...
Genki’s new customizable controller has a big screen and adjustable buttons
A controller that prioritizes personalization.
ChatGPT Can Now Control iMessage, Potentially Raising Apple Privacy Concerns
OpenAI rolled out support on Thursday for controlling Apple Inc.’s iMessage service via ChatGPT, a move with the potential to raise privacy concerns for the iPhone maker.
Relive the Original Xbox By Building Your Own 1:1 Scale 3,509-Piece Mattel Brick Shop Version
In celebration of the Xbox's 25th anniversary, Mattel has announced a 3,509-piece, 1:1-scale buildable original Xbox through its premium Mattel Brick Shop brand. And yes, it also includes a buildable 1:1-scale Duke controller and features lights, sounds, and scenes from three different classic Xbox games. It's available for preorder at a couple of different retailers for $329.99.
Xbox 25th Anniversary Controller: Release Date, Price & Other Details Seemingly Revealed
Expect an official announcement next week
How data can help pay for affordable healthcare in Africa
Healthcare in much of Africa continues to be limited. Here's how a mobile phone-based health model combines AI-supported care with citizen-controlled data.
Democrats seek to block a Trump-linked crypto bank
The Office of the Comptroller of the Currency granted conditional approval for the Trump family's World Liberty Trust Co. to become a bank handling cryptocurrency and digital assets.
The Big Interview With The Developers Of Big Walk
Three members of House House joined me for a stroll to talk about Big Walk’s development, puzzles, sounds, and its emotional ending.
Walter’s insurer to slash scrutinized loans by $6.5 billion
The move whittles down the more than $20 billion of loans that insurers controlled by Walter previously said should have been labeled as affiliated but weren’t.
Could GLP-1s help treat opioid use disorder? Vanderbilt Health study now enrolling
The study, Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder (TAB), is a double-blind, randomized, placebo-controlled trial conducted through the National Institute on Drug Abuse’s Clinical Trials Network.
Coming to XBOX Game Pass: Resonance: A Plague Tale Legacy, Vapor World: Over the Mind, Blood Dungeon, and More
We have more games coming your way on day one (including one you may have seen in our XBOX Games Showcase this summer)! Go grab your controller or mouse and let’s get to the games.
I'm not saying Bethesda are trolling me specifically, but Fallout 4 and Skyrim updates are imminent just as I've modded up the latter for the first time in ages
Fallout 4 and Skyrim updates are imminent, Bethesda have warned.
Why women with ADHD feel overwhelmingly 'controlled' by their hormones
People with ADHD are unusually sensitive to hormone shifts. Psychiatrists have started to pay attention, creating strategies to address the intense emotions and cognitive challenges caused by these changes
US prosecutors focus on four businesses tied to billionaire Mark Walter, WSJ reports
U.S. federal prosecutors looking into billionaire Mark Walter's empire are focused on four businesses that served as intermediaries between insurance companies he controlled, the Wall Street Journal reported on Sunday.
Cialis is an erectile dysfunction drug. Could it also help you live longer?
In some wellness circles, tadalafil is promoted as a longevity drug. There is evidence showing a link between it and a lower risk of death in men, but there are no well-controlled trials in humans.
Linux 7.2 debuts, Linus Torvalds says ‘new normal’ means he had to do it now ... or never?
Say hello to smarter use of caches to speed things up, and a very odd gaming controller. Say goodbye to some PCMCIA support
Trump administration demands hospitals share emergency room records
The CPSC, which protects the public from injuries caused by lawn mowers and strollers, is demanding that some of the nation’s biggest health systems turn over detailed, personally identifiable medical records of patients who seek emergency room help.
Exclusive | Prosecutors Focus on Four Businesses Tied to Dodgers Owner Mark Walter
Proceeds from loans made by Walter’s insurers passed through firms purportedly controlled by each of these four entities.
Republicans won the redistricting competition. Don't tell that to this California congressman
President Donald Trump last year told GOP-controlled states to redraw their maps before this year's midterm elections to increase the number of winnable seats for Republicans in order to help the party hold onto the U.S. House.
8BitDo just turned your iPhone into a perfect retro handheld with this clever controller
Your phone is now a Game Boy.
BREAKING: Netflix to shut down two more game studios
Netflix is sticking with video games but once again reducing the number of studios it owns making games. The streaming giant is closing Los Angeles-based Night School studio, which it acquired in 2021 and plans to close Helsinki-based Moonloot, which was founded in 2022. Just six weeks ago, Night School had released Unhinged, a novel 30-minute first-person horror game, streamable on TVs to Netflix users. The game was hailed by Netflix co-CEO Greg Peters in a call with investors. Six weeks later, Night School is closing. Prior to its Netflix tenure, Night School had developed the award-winning supernatural thriller Oxenfree. A second Oxenfree game followed after the purchase, as well as a mobile game designed to tie in to an episode of the Netflix show Black Mirror. Netflix attributed the studio closures to a prioritization around kids gaming, party games, story-driven fare and games with mainstream hooks, such as a recently released FIFA game. “We see an opportunity to be more focused in our execution, so we are making organizational changes to the business to match those priorities,” a Netflix spokesperson told Game File. Netflix is also cutting jobs from its internal games team. A rep declined to say how many jobs were being lost by these cutbacks. “We are incredibly grateful to the talented colleagues we’re saying goodbye to today. We thank them for all their contributions to Netflix, and wish them the best,” the rep said. Netflix started releasing video games, initially on mobile as a free bonus to subscribers, in 2021. By 2023, Mike Verdu, then the head of Netflix’s game operations, was telling me that the company was committed to growing carefully, as it offered more games and built up internal game studios. At the time, it hadn’t made any gaming job cuts. Since then, Netflix has altered its approach. In 2024, it shut down Team Blue, a start-up studio led by ex-Call of Duty and Halo developers that was exploring making a high-end first-person game for the service. Last October, Netflix shut down another studio, Boss Fight, shortly after Peters praised the team’s Squid Game game to investors. (One of Boss Fight’s main developers now works on the Netflix FIFA game for outside studio Delphi.) And in December, Netflix sold cozy game studio Spry Fox back to its founders. Amid all of this, Netflix has shifted from emphasizing mobile games to offering games through TVs and PCs, via streamed connections, with phones used as controllers. That’s how Night School’s Unhinged worked, along with games such as Boggle and Party Crashers that have collectively helped the Netflix game controller app chart well on mobile app stores. The studio cuts leave Netflix with a central gaming team that works with external developers, and a dedicated first party studio in, Helsinki-based Next Games, which produced many of the company’s couch-centric party games. The move away from having a roster of internal game studios aligns with Netflix’s own approach to shows and movies, which are largely produced externally. The company owns few TV/film production studios of its own. The gaming industry overall is seeing large holders of multiple studios cut back, with Sony, Ubisoft, Embracer, Microsoft and other giants closing or selling off studios. Cuts in California-based studios, where costs often run relatively high, have been particularly acute. Netflix has faced skepticism about its gaming plans for years. The moves today are likely to fuel them, and the company has few upcoming projects to counter the narrative. Among the few hinted, acclaimed independent studio Don’t Nod said last year it was working on a game tied to a major Netflix franchise.
Instagram Unveils New Logo and People Are Already Making Fun of It
Meta's Instagram proudly launched a new logo Thursday -- its first update in a decade -- and the trolling has already begun.
Only 12% of family businesses stay in the family by the third generation. A Goldman Sachs chairman says optimism is the reason
François-Xavier de Mallmann steers Goldman's relationships with many of the world's largest family-controlled enterprises.
Mamdani promotes budget; spending critiqued by Financial Control Board
The board is made up of the mayor himself, Gov. Kathy Hochul, the city and state comptrollers, and other appointees.
Xbox officially reveals its limited edition Gears of War E-Day controller, plus new Design Lab options
The controller and Design Lab update will both launch on September 30…
Xbox Reveals Stunning 3D-Moulded Gears of War: E-Day Limited Edition Controllers
Microsoft has announced a pair of highly-detailed Gears of War: E-Day Limited Edition Xbox controllers, which look just as gruff and grizzled as you'd expect.
Xbox unveils two awesome limited-edition Gears of War: E-Day controllers
With the launch of Gears of War: E-Day ebbing ever closer, Microsoft has now announced two limited-edition Xbox controllers to celebrate the shooter.
Siena poll: Hochul's lead over Blakeman narrows as voters weigh issues
Likely voters were also asked about statewide races for attorney general and state comptroller.
Purported Xbox Elite Series 3 Controller Prototype Somehow Ends Up in a Customer's Hands
The Xbox Elite Series 3 Wireless Controller hasn't even been officially announced yet, but a purported prototype has seemingly found its way into the hands of someone who thought they were buying an Elite Series 2 controller on the retail website OfferUp.
The Legend of Zelda 40th Anniversary Nintendo Switch 2 Console Images Reportedly Leak
Leaked images of a The Legend of Zelda 40th Anniversary Nintendo Switch 2 console and Pro Controller appear to be circulating online.
Playstation Announces 'Marvel's Wolverine' Limited Edition PS5 and Controller
Here's when you can pre-order the Marvel's Wolverine PS5 and DualSense controller
Zelda-themed Nintendo Switch 2 console and Pro Controller leaked
Nintendo is reportedly planning to launch a new limited-edition Zelda-themed Nintendo Switch 2 console and a matching Pro Controller to celebrate the series' 40th anniversary. And a new leak has now given us our first look at the hardware.
Zelda Nintendo Switch 2 system and Pro Controller leaked, first images
Get a first look at the brand new Nintendo Switch 2 system and Pro Controller based on The Legend of Zelda with this new leak.
Marvel's Wolverine Limited Edition PS5 Consoles, Controllers Announced, Pre-Orders Next Week
Nice PS5, bub
Blue Jays Provide Latest Health Update on Spencer Arrighetti
The Toronto Blue Jays have provided the latest health update on starting pitcher Spencer Arrighetti, who came over at the trade deadline. The Blue Jays traded center fielder Daulton Varsho and cash to the Astros for Arrighetti, a young, controllable starting pitcher who had fallen out of favor in Houston. He was on the IL […] The post Blue Jays Provide Latest Health Update on Spencer Arrighetti appeared first on HEAVY.
Saber's newest game trailer takes a shot at Gearbox's CEO, if you look closely
The first hint that something might be up with the recent debut trailer for Saber Interactive’s Rideshare Stimulator is an unusual choice of words—aside from that second one in the game’s title. “Don’t take your passengers too seriously,” the trailer’s narrator says, as he describes this upcoming game. It a car game about the gig work of driving eccentric people to their destinations, a riff on Crazy Taxi. And then, he says: “When I think I’ve met the randiest of passengers, someone even stranger gets in.” “Randiest”? That suggests “randy,” which usually means having strong sexual desire. Yet none of the oddball backseat occupants featured in the trailer seem particularly lustful. One is an old man who considers his grandson a failure, another shares the theory that birds might control traffic lights, another says he’s banned from an aquarium. A little later, there’s a license plate, shown 63 seconds into the trailer, on the front of an SUV: USB DRV It’s a Texas plate. The symbol between those letters is a cog wheel. If you know, you know. That’s a reference to Texas-based Borderlands game development studio Gearbox Software (their logo features a cog wheel). More specifically, it’s a reference to Gearbox’s CEO Randy Pitchford, who in 2018 found himself explaining the nature of video he’d saved on a USB drive that was found at a Medieval Times restaurant before being returned to the studio: “It was ‘barely legal’ porn. This girl’s handle was ‘Only 18.’” The “girl” in the video had committed a solo sex act that Pitchford, an avid practitioner of magic, found remarkable. “I realized, this is not a sex worker…This is a fucking magician.” Back then, the USB drive was central to competing lawsuits against Gearbox by the studio’s former lawyer and by Gearbox against him. A settlement in late 2019 “exonerated” Pitchford, per the Hollywood Reporter. The USB story has resurfaced at times, now in a trailer from a company that not long ago was corporate brethren with Gearbox. Saber vs. Gearbox The head of Saber told Game File that the reference is payback. “The dig is because Randy took shots at Embracer in Borderlands 4,” Saber CEO Matt Karch told me when I asked him about the license plate. “Without Embracer, Randy is performing magic tricks at birthday parties for a living.” Having interviewed Karch during a cross-country flight in late 2024, I can confirm that Karch was unimpressed with Pitchford during their time both working in the Embracer group. I’d approached him not out of surprise that there was animosity but that it was manifesting publicly now. Gearbox was founded in 1999, worked on a port of Halo early on, and developed hit series such as the loot-based sci-fi shooter Borderlands before it was purchased by The Embracer Group in early 2021 for $363 million (with a possible earn-out of over $1 billion, if certain targets were hit by 2027). Saber was founded in 2001, worked on a remaster of Halo early on, had a big hit with zombie shooter World War Z and was purchased by Embracer in early 2020 for $150 million, with a potential earn-out of up to $375 million. For a few years, the Embracer group was a voracious acquirer of game studios. Then, as investment dried up, it choked. In March 2024, Embracer sold Saber to an investment company controlled by Saber CEO Matt Karch, and it sold Gearbox in an all-stock deal to long-time Borderlands publisher Take Two Interactive. Other studios were shut down. Hundreds of developers were laid off. Gearbox didn’t say much about their Embracer experience, nothing too direct, at least. In the summer 2024, Pitchford told reporter and occasional Game File contributor Nicole Carpenter that Borderlands 4’s story was in some way thematically connected to Gearbox’s experience at Embracer: “There’s this cultural and emotional shift in me, personally, and at the studio. What does it mean to trade some autonomy for organization?” When Borderlands 4 came out, there was something stranger: the matter of “Embracer’s Bluff,” a location in the game featuring an AI-powered toilet and a large trash dump, according to a detailed Kotaku account of the place. Gearbox never commented on it; Take Two never got back to me about it when I asked them last year. By contrast, since Saber exited Embracer, Karch has been one of Embracer’s biggest defenders, casting their management as well-meaning and supportive despite the layoffs and studio closures that resulted from their excessive expansion. Like others, Saber’s Karch saw Embracer’s as a shot. With Rideshare Stimulator’s trailer, he’s returned fire. “It’s amazing to me how fast people forget those who went above and beyond for them,” Karch told Game File. A rep for Gearbox did not comment by press time. Game File is a reader-supported publication. Your backing makes my reporting—including any coverage of trailer-based beefs—possible. Good news! I’m currently running Game File’s first big sale of 2026. You can get a one-year subscription for 23% off. Click here to take advantage of the limited-time offer. And thank you for your support! Item 2: In brief… 🚫 Wal-Mart has laid off the staff of Restart, a games media outlet launched in 2024, Aftermath reports. 🟥 A GTA VI preview is on the way, at last, via an “extended look” that will premiere, unusually, on Netflix at 3pm ET on August 27, then officially go live elsewhere six hours later. Last week, Game File noted that Take Two label Rockstar Games is overdue for showing off GTA VI, based on the timing of the initial hands-off previews of GTA V and Red Dead Redemption 2. During a call with investors, Take Two CEO Strauss Zelnick said pre-orders for GTA VI were “unprecedented and astonishing,” but added the company can’t predict how many of those pre-orders represent bonus sales vs. sales that otherwise would have been made at launch. During the same call, Zelnick was noticeably bullish on the future of playing games over streaming cloud connections (predicting wider adoption in three or so years). He sounded unbothered by Sony’s plans to stop making discs for new games (he said the business is 90% digital already and predicted that there could still be limited edition physical editions of games “in the same way there’s still vinyl in the recorded music business.”) 👀 Take Two wrote off $43 million in their spring quarter after deciding “not to proceed with further development of an unannounced title in its pipeline from a third-party developer.” 🤔 Some rare age-demographics from a big publisher: Capcom recently told investors that “users in their 20s account for approximately half of the users of both Pragamata and Resident Evil Requiem.” Item 3: The week ahead Tuesday, August 11 Game releases: The Elder Scrolls IV: Oblivion Remastered (Switch 2; already out for PC, PS5, Xbox) continues the Bethesda strategy of putting Elder Scrolls games on everything; Royalty Free-For-All is a Smash Bros.-style fighting game featuring public domain characters such as Mother Goose brawling with Oliver Twist in a stage based on the original Little Shop of Horrors movie. Wednesday, August 12 Game release: Pro Jank Footy (PC, console) is an arcade-style Australian Rules Football game with increasingly ridiculous rules, the more you play (I enjoyed the Steam demo) Thursday, August 13 Game release: Super Mario Sunshine (Switch 2, originally released in 2002 on the GameCube) is released for Switch 2’s Nintendo Switch Online service. This game is the black sheep of 3D Mario games. It’s the successor to the breakthrough Super Mario 64 and the rare Mario game built around a single (vacation resort) theme. Mario’s got a water-spraying backpack, a Yoshi pal and a lot of blue coins to collect.
PHOTOS : Science Stroll Draws Crowd To Woods Hole
Woods Hole was buzzing with curiosity during the annual Science Stroll, as families filled the village for hands-on activities and a look at the ocean science happening in their own
PSA: Steam Machine and Steam Controller Customers in Europe Hit by Cyber Attack
"Expect fake messages that mention your hardware order and appear to come from Valve."
What Lies Beneath: The Shocking Truth About Carbon Hidden Underground - Futura-Sciences
The Surprising Underground Wilderness This fall, many of us will stroll through forests in search of that elusive perfect mushroom for dinner. But researchers at the University of Michigan (United States) have gone a fair bit further—and deeper. For the very first time, they succeeded in quantifying the abundance of...
Local organizations put on family-friend science fest Saturday
Woods Hole Science Stroll was held Saturday. Family-friendly activities were put on by Woods Hole's six major science institutions and others.
Athletics Part Ways With Former General Manager
The Athletics have parted ways with former general manager David Forst after a season in which the team has struggled to win games.With a 45-70 record this season, the Athletics have been one of the biggest disappointments in all of MLB. Armed with a load of young, talented, and controllable players, things have seemingly fallen […] The post Athletics Part Ways With Former General Manager appeared first on HEAVY.
How Memphis voters feel now after Tennessee split up its majority-Black district
Memphis voters say they’re frustrated with what they felt was a bald move by the Republican-controlled Legislature to eliminate Tennessee’s only Democratic representative in Congress and dilute the will of the majority-Black city.
Sony’s new PS5 Pro beta update automatically enables PSSR 2.0 for every game
Sony’s latest PS5 system software beta enables PSSR 2.0 by default across all PS5 Pro games, promising sharper visuals and fewer frame-rate drops without requiring manual setup.
Insults, Expletives and Fat-Shaming: Vance Trolls Critics on the Right and Left
The vice president has dispensed with the decorum and restraint of his predecessors to directly take on opponents and journalists on social media with sometimes profane and often personal jabs.
Federal probe of Guggenheim CEO Mark Walter reaches Chicago
Investigators are examining loans involving a little-known Wacker Drive trading firm as part of a broader inquiry into businesses controlled by the Dodgers owner.
Were the primaries a preview for consequential general election?
Colorado’s political future will go the way of this election. Historically, the state has not had both chambers controlled by a supermajority. This election may change that. The primaries suggest how the general election may play out. Democrats had solid voter turnout and unaffiliated voters leaned toward Dems. The party pulled in 404,132 unaffiliateds to […]
Billionaire Agarwal’s Vedanta Unit Seeks Mega Loan After Business Split
A unit of India’s Vedanta Group is raising about 135 billion rupees ($1.4 billion) from at least three banks, the first large local-currency loan since the conglomerate controlled by billionaire Anil Agarwal was split into separate firms, according to people familiar with the matter.
Sanofi suspends chronic lung disease phase 2 study, tied to ‘strategic business reasons’
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce Biotech has learned. The trial, which began only back in April, was a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score following treatment with SAR445399 compared with placebo in adults aged 18 to 80 years with NCFB, a chronic lung disease. The trial was officially reported as halted on July 29, the day before Sanofi’s second-quarter earnings call. The decision to pause the trial was made “as part of a company-wide portfolio review for strategic business reasons,” and not due to safety concerns, a Sanofi spokesperson told Fierce. The move to pause the NCFB trial comes during a trying time for Sanofi following a year filled with a series of trial fails. In February, the French pharma ousted CEO Paul Hudson and appointed Merck KGaA leader Belén Garijo, M.D., Ph.D., to steer the ship. Since then, Garijo has been doing a deep dive on correcting the company’s strewn R&D and clinical strategies. On July 24, Sanofi scrapped amlitelimab for atopic dermatitis, despite its lore as being a potential $5 billion blockbuster. During its second-quarter report, the company abandoned two more assets, balinatunfib and itepekimab, following failed trial results in psoriasis and chronic obstructive pulmonary disease, respectively. SAR445399, only first revealed by Sanofi in 2023, is an anti-interleukin-1 receptor 3 monoclonal antibody developed to block the interleukin 1, 33, and 36 cytokine pathways. These pathways can be important in chronic immune-related dermatologic diseases, such as atopic dermatitis and hidradenitis suppurativa, as well as respiratory conditions, such as NCFB. Related Sanofi’s new CEO ‘looking deeply’ at late-stage pipeline as clinical clearout continues NCFB affects roughly half a million people in the U.S., with a global incidence of greater than one million cases. In August 2025, Insmed received FDA approval for Brinsupri, a DPP1 inhibitor targeting neutrophil activation, for treatment of NCFB in adults and kids ages 12 and older. The British biotech Infex Therapeutics showed promising NCFB phase 2a data using their monoclonal antibody, INFEX702, which acts by disabling Pseudomonas aeruginosa, a bacteria known to be a major pathogen of NCFB. Sanofi is currently running a separate phase 2 study testing SAR445399 as a potential treatment for the inflammatory skin condition hidradenitis suppurativa.
Steam :: Steam Hardware :: Getting the most out of your Steam Controller: Gyro
A guide for the motion controls with the Steam Controller
Seven takeaways from Ravens’ first padded training camp practice
Lamar Jackson struggled, Ja’Kobi Lane went deep and Baltimore’s defense controlled the Ravens’ first padded camp practice.
Monster Fest provides entertainment for children and adults
CONNEAUT — The Conneaut Art Center lawn was a busy place on Saturday with a variety of characters strolling the premises.
Scientists twist crystal layers and reshape matter from within
Researchers have found a way to build much larger “twisted” oxide materials while precisely controlling how their atomic layers line up. Because these materials can be made over large areas and transferred onto different surfaces, the technique could help turn twistronics from a laboratory curiosity into a practical platform for next-generation electronics.
Security guards turnover is pushing some companies toward robots
Asylon's robot dogs and drones are patrolling large facilities as the security industry faces a retention problem.
Dunedin open container district: Businesses push for outdoor drinking
Local business owners are pushing city leaders to let downtown happy hour spill onto the sidewalks to help rescue slumping summer sales.