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Jenks America Food Truck Festival returns with specialty foods and live entertainment
Foodies unite! The annual Jenks America Food Truck Festival is back this month with a wide selection of specialty foods.
EPA announces new selections to Science Advisory Board
The U.S. Environmental Protection Agency (EPA) has announced the selection of new members to its Science Advisory Board (SAB), which provides expert
'Calculated' Salah has 'sensed an opportunity and taken it'
Not for the first time this season, Mohamed Salah seems to have taken a thinly veiled dig at the manager. You can't apportion blame when we don't know the full story and why Salah feels the way he does. It will now be interesting to see in that final game of the season at Anfield, his farewell to the supporters and the City, how Slot reacts in terms of team selection and how the fans react to a legend going out in unsavoury fashion.
6 Portable Entertainment Gadgets To Buy From Costco (And 5 To Skip)
Costco can be a great place to find deals on all sorts of technological goodies, but though its selection is wide, not everything is worth shelling out for.
6 Portable Entertainment Gadgets To Buy From Costco (And 5 To Skip)
Costco can be a great place to find deals on all sorts of technological goodies, but though its selection is wide, not everything is worth shelling out for.
4 Takeaways From France's World Cup Roster Selection
Even with some notable omissions and Kylian Mbappé's drama at Real Madrid, this France squad is simply the team to beat.
NBA Draft lottery: Wizards secure No. 1 pick in one of the most anticipated drafts ever; Pacers lose selection
Crystal Palace 2-2 Everton - send us your thoughts
Whether you were at the game or following from elsewhere, we want to know what you learned. Come back on Monday for a selection of your replies
Patrick Mahomes' Wife, Brittany, Lands Prestigious Award
Patrick Mahomes has a bunch of awards nine years into his NFL career. The Kansas City Chiefs quarterback has three Super Bowl trophies, two league MVP trophies, an NFL Offensive Player of the Year Award, six Pro Bowl selections and three All-Pro selections. His wife, Brittany, is now adding ...
March Madness expands to 76 teams as committees lock in long-term men's, women's NCAA Tournament change
A Thursday vote that was long awaited will now trigger the polarizing expansion of college basketball's most cherished event
NWA Business Journal seeks nominations for awards programs - Talk Business & Politics
The Northwest Arkansas Business Journal is accepting nominations for multiple awards recognition programs, including its longest-running awards program, Forty Under 40. Selection to the recognition programs is based on nominees’...
Dez Bryant's Son Receives Scholarship Offer from Oklahoma State Cowboys
The Dallas Cowboys selected wide receiver Dez Bryant out of Oklahoma State with the No. 24 pick in the 2010 NFL Draft. All three of his Pro Bowl nods and one First-Team All-Pro selection also came with the Cowboys. The wide receiver out of Southlake, Texas is an unranked recruit in the 2028 cycle, according to 247Sports.
Analyst reveals surprising choice for favorite Chiefs draft selection
This might not be everyone's choice.
NFL Draft Expert Reassures Bears Fans About Polarizing Pick
An NFL expert defends a surprising third-round tight end selection, revealing strategic foresight for the Bears' future personnel and blocking needs.
'Aberdeen not safe yet'
Aberdeen fans, we asked for your views on Friday night's 2-2 draw against Livingston. Chris: To be perfectly honest after last night my worry is Stephen Robinson and his team selection. As time passes my real fear is who Robinson will show the door and who will come in.
The MED Foundation of Mercer Health Awards $22,500 to Local Students Pursuing Careers in Healthcare
The Medical, Educational and Development (MED) Foundation of Mercer Health recently awarded a total of $22,500 to local high school seniors furthering their education in the medical field after graduation. Scholarships were awarded to students from each of the six high schools in Mercer County. All applicants were interviewed by a scholarship selection panel, and […]
World Heroes Perfect ‘NEO GEO Premium Selection’ edition announced for PC
SNK has announced a new version of 1995-released fighting game World Heroes Perfect for PC (Steam) as part of its “NEO GEO Premium Selection”—a selection of NEO GEO titles upgrade…
ESPN reveals Chiefs selection was favorite move of NFL Draft
The Chiefs knew who they wanted, and made it happen.
Arkansas Health Insurance Marketplace Data Show Changes in Enrollment, Plan Selection, Premiums
New data from the Centers for Medicare and Medicaid Services show that marketplace plan enrollment in Arkansas decreased by 3.8% in the 2026 open enrollment period compared to 2025, but there was a shift in the types of plans selected and a notable increase in average plan premiums.
Scientific grades for Day 3 selections: Cowboys closed out strong?
The Cowboys snagged some good prospect but that doesn't mean they aced the 2026 NFL draft. Looking at things more objectively how did they grade?
USA TODAY graded every NFL Draft pick. How did Iowa, Iowa State rank?
USA TODAY Sports graded all 257 picks in the 2026 NFL Draft. Here’s how every Iowa and Iowa State selection was evaluated.
Ranking each team's 2026 NFL Draft class: Chiefs, Browns, Jets crush it; Steelers, Rams, 49ers raise questions
Keep reading to see how your team did -- everything from our favorite picks to best values to most surprising selections
Grading the New York Giants’ 2026 NFL Draft Picks
Ahead of the 2026 NFL Draft, many questions arose about what the New York Giants would do, especially after trading former All-Pro Dexter Lawrence for the 10th overall pick. With their two top 10 selections, as well as trading into the third round, the Giants showed great aggression for their needs. But, with these premier […] The post Grading the New York Giants’ 2026 NFL Draft Picks appeared first on The Lead.
Kirkwood junior, Rossview senior earn Tennessee Sports Writers Association all-state honors
The Tennessee Sports Writers Association has announced their all-state selections for the 2025-26 high school basketball season, with two Clarksville-area players.
Google could soon say goodbye to current Gemini voices (APK teardown)
Like Gemini's current selection of voices? There's bad news as an Android Authority teardown has revealed that they'll be discontinued.
Scientists Discover 479 Gene Variants Shaped By Natural Selection In The Last 10,000 Years
Natural selection in an unnatural world.
Sound Smart: 5 Observations from the 2026 NFL Draft
Key insights in the wake of the 2026 NFL Draft, including a behind the scenes look at Ty Simpson's selection, the surprise pick of the year.
Relative Athletic Scores for Colts 8 2026 NFL draft picks
Here are the Relative Athletic Scores for the Colts' 8 selections in the 2026 NFL draft.
Patriots prioritize depth, competition to close out NFL Draft
The Patriots made six selections on the final day of the draft.
2026 NFL Draft grades, tracker: Rams earn high mark with selection of Ty Simpson
Mike Renner grades the first 32 picks of the 2026 NFL Draft.
2026 NFL Draft grades, tracker: Live Round 7 analysis for every selection made in order
Josh Edwards grades the seventh round of the 2026 NFL Draft.
Patriots trade 191st pick to Jaguars for pair of selections
New England moved down in the sixth round of the draft.
2026 NFL Draft grades, tracker: Live Round 6 analysis for every selection made in order
Josh Edwards grades the sixth round of the 2026 NFL Draft.
Denver Broncos select PLAYER with their 170th overall selection
With their 152nd overall selection in the 5th round of the 2026 NFL Draft, the Denver Broncos select NC State TE Justin Joly The Athletic’s Dane Brugler had Justin Joly as his TE5 in this draft and had a 3rd/4th round grade on him. Now, the Broncos trade up to get him in the 5th […]
Why the Broncos drafted OL Kage Casey
With their 111th overall selection in the 2026 NFL Draft, the Denver Broncos selected Boise State offensive linemen Kage Casey. He is a 6-5, 310-pound offensive lineman who played tackle in college, but was announced as a guard and is expected to provide depth at the interior of the Broncos’ offensive line. He will join […]
2026 NFL Draft grades, tracker: Live Round 5 analysis for every selection made in order
Josh Edwards grades the fifth round of the 2026 NFL Draft.
2026 NFL Draft grades, tracker: Live Round 4 analysis for every selection made in order
Josh Edwards grades the fourth round of the 2026 NFL Draft.
2026 NFL Draft Day 3 live picks tracker with grades: Every selection in Rounds 4-7
Day 3 of the 2026 NFL Draft is here. USA TODAY Sports will be tracking all 157 remaining selections and providing grades for the most notable picks.
Sean McVay downplays 'grumpy' demeanor after Rams' selection of Ty Simpson, embraces GM Les Snead
2026 NFL Draft grades, tracker: Live Round 3 analysis for every selection made in order
Mike Renner grades the third round of the 2026 NFL Draft.
2026 NFL Draft grades, tracker: Live Round 2 analysis for every selection made in order
Mike Renner grades Round 2 of the 2026 NFL Draft
NFL draft picks tracker: Analysis for every 2026 second- and third-round selection
The 2026 NFL draft is fully underway. The Round 2 and 3 tracker offers instant analysis on all 68 picks made Friday night in Pittsburgh.
How Pittsburgh — host of this year's NFL draft — became a sports mecca
The Pennsylvania city is hosting the draft for the first time in almost 80 years. Pittsburghers say the city's passionate fanbases and winning teams make the selection a natural fit.
2026 NFL Draft: American Conference prospects to watch
Eli Heidenreich, Landon Robinson, and Travis Burke are among the most likely American draft selections in 2026.
Grading Commanders' selection of Sonny Styles in 2026 NFL Draft
Here's how we graded the Commanders' selection of Sonny Styles in the 2026 NFL Draft.
Seahawks fans behind Jadarian Price selection at No. 32 overall
Seahawks fans reacted positively in large part to Jadarian Price being selected by Seattle with the No. 32 overall pick in the NFL draft.
Knicks lose, Mets blow 4-run lead and Jets make much-criticized NFL Draft selection in wild 4 minutes for New York sports
Dallas Cowboys NFL Draft tracker: Picks, grades, analysis for every selection
Track every Cowboys pick in the 2026 NFL Draft with live grades, analysis and updates
NFL draft picks tracker: Analysis for every 2026 first-round selection
The 2026 NFL draft is finally here. The first-round tracker offers instant analysis on all 32 picks made Thursday night in Pittsburgh.
2026 NFL Draft: Meet Arvell Reese, the Edge Rusher the Giants Took at No. 5
FOX Sports analysts give their thoughts on the draft selection of Ohio State linebacker Arvell Reese.
Maggie Gyllenhaal to lead Venice Film Festival jury
Maggie Gyllenhaal is set to lead the main competition jury for the 83rd Venice International Film Festival. Festival organizers announced the selection Thursday. Gyllenhaal, who directed “The Bride!” and “The
College football's active coaches who have produced the most all-time NFL Draft selections
When it comes to developing next-level talent, these coaches are college football's best
Today in Boston Celtics history: Swain, Smith drafted; Coles born
Today in Boston Celtics history, the team made a pair of selections that made the roster in the 1958 NBA Draft.
Washington's County's most improved high school spring sports athletes
Washington County's high school varsity spring sports head coaches were asked who their most improved athlete is. Here are their selections.
EPA announces selection of members to the Science Advisory Board
U.S. EPA Administrator Lee Zeldin on April17 announced the selection of new members to the Science Advisory Board, which consists of a chair and 36 members. Three of the selected members will also serve on the SAB Agricultural Sciences Committee.
Shirley in Top Four for Arthur Ashe Jr. Sports Scholars Award - NC State University Athletics
Defensive tackle Isaiah Shirley continues to move up in the selection process for the 2026 Arthur Ashe Jr Sports Scholars Award.
Washington County's 2026 high school spring sports 'Unsung Heroes'
I asked Washington County's spring sports varsity head coaches one question: Who is your team's unsung hero? Here are the coaches' selections.
Between Providence And Boston Is A Vibrant Massachusetts Town Bursting With Diverse Entertainment
Foxborough, known as "Foxboro," is a lively Massachusetts town that's home to the Patriots, Gillette Stadium, and a diverse selection of local entertainment.
2026 NFL mock draft: Commanders trade down after Jeremiyah Love flies off board in top five
Projecting the 2026 NFL Draft's first round with Jeremiyah Love's selection leading to changes.
Opening statements set for Tuesday in Harvey Weinstein's rape retrial
Opening statements are set for Tuesday in Harvey Weinstein’s third trial on a New York rape charge. Four days of jury selection wrapped up Friday. A jury of seven men
Red hair gene favoured by natural selection over last 10,000 years, study finds
Scientists suggest red hair and fair skin were favoured for vitamin D efficiency in study focused on whether human evolution plateaued after advent of agriculture
ICARUS experiment marks major milestone in first neutrino science results
The milestone by ICARUS paves the way to probe sterile‑neutrino oscillations for the full Short-Baseline Neutrino Program at Fermilab. The first results demonstrate the data’s excellent quality and suitability for physics analyses, as well as the maturity of the software tools for event selection, fitting and detector simulation.
Nature Is Still Molding Human Genes, Study Finds
Some researchers hold that evolution hasn’t much altered humans in the past 10,000 years. A new analysis of ancient DNA indicates that natural selection continued to shape hundreds of genes.
Jury selection starts for Harvey Weinstein's latest retrial in N.Y. rape case
It's the third time that jurors will weigh whether he raped a woman.
Indiana Fever fans react to 2026 WNBA Draft haul
Following the completion of the 2026 WNBA Draft, here are some of the most notable social media reactions to the Indiana Fever's three selections.
WNBA draft picks are about to get paid like never before: 'It's an incredible time'
This year’s top draft pick is projected to earn $500,000, six times the $78,000 last year’s No. 1 selection was paid.
UCLA makes WNBA draft history with record number of selections
Entering Monday night, UCLA had only produced six first-round draft picks since 1997. The program nearly matched that at the 2026 WNBA Draft alone.
Kansas Sports Hall of Fame announces 32-member class of 2026
The 32 selections will be honored at one of three events this summer.
Apple's New M5 MacBook Air Hits $949 Record Low Price on Amazon
Amazon has introduced a few new record low prices on the M5 MacBook Air this week, with up to $150 off these notebooks. We started tracking these deals over the weekend, and the selection of color options at best-ever prices has only expanded since then. Note: MacRumors is an affiliate partner with Amazon. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
MHSAA girls basketball: Free Press 2026 All-East teams
Here are the Free Press selections for the All-East metro teams for the 2025-26 high school girls basketball season.
Is it time for both parties to bail on Colorado’s political nominating system?
Cracks are beginning to appear in Colorado’s political nominating system. Recently, Mario Nicolais, a formerly Republican-leaning pundit, and Doug Friednash, former Democratic legislator, have opined regarding the imminent demise of the caucus/assembly framework which controls partisan candidate selection. There has always been a legal detour around this process whereby candidates petition directly onto the ballot. […]
2025-26 CBS Sports All-America teams: College basketball's best and most talented players
Duke's Cameron Boozer, Michigan's Yaxel Lendeborg, BYU's AJ Dybantsa and Arkansas' Darius Acuff Jr. were unanimous first-team selections
Here's That Random Selection Of Ads From A 1969 Issue Of 'Popular Science' You Wanted So Badly
Remember how you woke up last night, screaming and drenched in sweat, and reached for your phone to give me a call? You sounded pretty unhinged, I’ll be honest with you, and if you can deal with even more honesty, you were scaring me a bit. You asked – no, wait – demanded that I […]
Apple Adjusts Studio Display XDR Pricing Weeks After Launch
Apple has quietly reduced the price of the Studio Display XDR when configured with the VESA mount adapter, dropping it from $3,299 to $2,899 – a $400 cut. The nano-texture VESA version has also dropped from $3,599 to $3,199. Apple has also reworked the purchasing pattern on its website, making the stand choice the first step in the configuration process instead of the glass selection. When the Studio Display XDR launched last month, both stand options cost the same $3,299.
MHSAA boys basketball: Free Press 2026 All-North teams
Here are the Free Press selections for the All-North metro teams for the 2025-26 MHSAA boys basketball season.
UK HealthCare announces new director of Gill Heart & Vascular Institute
After an intensive national search and selection process, UK HealthCare leadership announced that Vedant Gupta, M.D., has been selected as the director of the Gill Heart & Vascular Institute and leader of the cardiovascular health service line.
Final Four in Indianapolis: IU sports media students will report and write from sidelines
Sixteen students from the Bloomington and Indianapolis campuses will report on the Final Four as well as the National Invitation Tournament semifinals and...
Pittsburgh black-owned businesses express frustration over NFL draft selection process
B. Marshall, Juneteenth promoter, said, "They are contracting businesses to work for the NFL to do certain functions."
Column: The time has come to discard California's top-two open primary
We should consider returning to a primary system that produces party nominees — one Democrat and one Republican — to give voters a more varied selection in November.
Business briefs: New businesses coming to NKY - Marshalls, Fruit Land, Penn Station
Staff report Marshalls to open in Cold Spring Pointe Marshalls, one of the nation’s leading off-price retailers with over 1,200 stores currently operating in 48 states, D.C., and Puerto Rico, will open at Cold Spring Pointe on April 9. Shoppers in Cold Spring will find an amazing selection of high-quality merchandise across fashion, accessories, shoes,...
Maxence Lacroix ‘dreams’ about playing at the 2026 World Cup
His first selection for the French national team has barely sunk in, yet Maxence Lacroix (25) is already looking ahead to his future with Les Bleus. With, of course, the World Cup firmly in his sights...
Malik Willis briefed on Jaylen Waddle trade before it happened
Earlier this month, the Miami Dolphins shocked their fan base by trading one of the team’s most beloved and dynamic stars — wide receiver Jaylen Waddle. The former first round pick was packaged with a fourth round pick and sent to the Denver Broncos in exchange for 2026 first, third and fourth round selections. While […]
Eagles face early-round pressure to address two glaring needs
Two of Eagles' top draft needs must be addressed sooner in the selection meeting rather than later.
How to Break America’s Great Scientific Stagnation
President Trump’s selection of Jim O’Neill to head the National Science Foundation could open the next great chapter of discovery.
All-League Greyhounds in winter sports named | Healdsburg Tribune | Local News Healdsburg, California
“What’s impactful about these selections is that they are decided on by all of the peer head coaches in the girls league. Each girl is talked about; some advocated for stat by stat, others in a speech-like cadence. These girls selected are getting head nods from all these other coaches. It’s a special recognition.”
Seahawks Survey: What will John Schneider do with pick 32?
Trade or stick and pick? What will the Seahawks do with their first-round selection?
Joe Flacco returning to Bengals: 41-year-old QB set for 19th NFL season in 2026
Flacco is coming off his first Pro Bowl selection.
Joe Flacco reportedly agrees to return to Bengals
Flacco went 1-5 in his starts with the Bengals and earned a Pro Bowl selection.
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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