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MGM Resorts International vs. Caesars Entertainment: Which Consumer Stock Is a Better Buy in 2026?
MGM leverages global luxury and digital expansion, while Caesars commands a vast U.S. footprint and loyalty program.
NCAA Men’s Golf: Arizona falls to UCLA in semifinals
Arizona men’s golf’s best postseason in decades ended just short of competing for a national championship. The Wildcats fell to UCLA in the NCAA semifinals Tuesday at Omni La Costa Resort in Carlsbad, Calif. after knocking off Vanderbilt earlier in the day in quarterfinals action. Arizona’s run to the semifinals marks the program’s best finish […]
Stocks making big moves yesterday: Everpure, Nvidia, AMC Entertainment, Redwire, and MGM Resorts
Check out the companies making headlines yesterday: Everpure (NYSE:P): Data storage solutions provider Everpure (NYSE:P) rose by 6.1% on Monday after Park Pl...
Hershey Entertainment, Resorts reaches tentative agreement with union
Hershey Entertainment and Resorts has reached a tentative deal with the chocolate workers union, Local 464.
Hershey Entertainment & Resorts reaches tentative agreement with union, company says
HERSHEY, Pa. (WHTM) — The union representing workers at the remaining Hershey Entertainment & Resorts Properties without contracts reached a tentative contract agreement, the company said…
Hershey Entertainment & Resorts, Local 464 reportedly reach tentative contract agreement
Hershey Entertainment & Resorts reaches tentative agreement with union, company says
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Barry Diller’s People Inc. Plans a Takeover Bid for MGM Resorts
The mogul’s People Inc. is preparing an offer to buy the portion of the casino giant that it doesn’t already own, at an $18 billion valuation.
Barcelona and Atletico Madrid emerge as prime contenders to sign Portuguese international
Barcelona and Atletico Madrid have been at loggerheads with each other throughout this summer over Julian Alvarez, with the latter resorting to defaming Barça.But Alvarez will not be the only bone of...
Where will the next big casinos be built in Las Vegas Valley?
Red Rock Resorts, Boyd Gaming Corp. and Anthony Marnell III all have big stakes in where the gaming industry will grow the most in the Las Vegas Valley.
Veteran Allgaier holds off rookie Crews to win Sports Illustrated Resorts 250
Veteran NASCAR O'Reilly Auto Parts Series driver Justin Allgaier raced to the victory at the Sports Illustrated Resorts 250 Saturday night at Nashville Superspeedway.
How to live stream Sports Illustrated Resorts 250: NASCAR O’Reilly Auto Parts Series, TV channel
The NASCAR O’Reilly Auto Parts Series heads to Nashville Superspeedway on Saturday evening for the Sports Illustrated Resorts 250. Tune in to The CW to catch the racing action. MORE: Richard Childress Racing makes major decision on Kyle Busch’s No.…
High Point Wins 2025-26 Sasser Cup Trophy
HILTON HEAD, S.C. (www.BigSouthSports.com) – High Point University has been awarded the Big South Conference’s George F. “Buddy” Sasser Cup Trophy for the 2025-26 athletic season, marking the school’s fifth consecutive year achieving the top overall athletic season in the Big South. The Cup was presented to High Point Thursday evening at the league’s annual Hall of Fame & Awards Banquet, which was held at the Westin Resort & Spa in Hilton Head, S.C. The Panthers also clinched the league’s Women’s and Men’s All-Sports trophies for the third-straight year -- becoming the first member institution to sweep all three awards in back-to-back-to-back seasons.
The acquisition of Caesars Entertainment includes other Strip resorts
The sale of Caesars Entertainment is set to bring a wide swath of Las Vegas Strip properties under new ownership, extending far beyond the Caesars Palace name.C
Billionaire Tilman Fertitta to acquire Caesars Entertainment for $17.6B
The lucrative deal combines the hospitality magnate's leisure empire with one of the two largest casino operators in Las Vegas.
Caesars Entertainment, a Las Vegas Strip icon, is sold for $6 billion
Caesars faces mounting pressure as fewer visitors to Las Vegas — its core market — dent revenue at resorts, hotels and casinos.
Opening Day to Banana Ball: The Evolution of ESPN Wide World of Sports
Since its opening in March of 1997, ESPN Wide World of Sports Complex at Walt Disney World Resort has hit the ground running, growing into one of the most dynamic sports destinations in the country. Beginning as an ambitious Disney World expansion in the late 1990s, this 260+ acre multi-sports wonderland offers amateur, collegiate, and
Fertitta-Owned Firm to Buy Caesars Entertainment in Nearly $18 Billion Leisure Push
May 28 (Reuters) - Caesars Entertainment said on Thursday it will be bought out by Tilman Fertitta-owned firm in a $17.6 billion deal, as the hospitality billionaire looks to expand his leisure empire. The deal, which will take one of the Las Vegas Strip's most prized casino operators private,
Caesars acquired by Fertitta Entertainment in $17.6B deal
The combination would bring Caesars’ iconic resort portfolio and digital gaming platform under the same roof as Fertitta’s Golden Nugget Hotels & Casinos and Landry’s restaurant brand.
UCF Alumnus Makes Epic Mark in the World of Themed Entertainment
As a performance coordinator at Universal Orlando Resort, Christian Spencer ’23 ’26MS is applying the unique insight he’s developed through UCF’s hospitality management and themed experience programs to elevate guest experiences.
Sports Illustrated resort project to break ground in Tuscaloosa
Developers will begin construction Wednesday on the Sports Illustrated resort near Rice Mine Road in Tuscaloosa, featuring a hotel, vacation club, and residential condos.
Assessing Melco Resorts & Entertainment (NasdaqGS:MLCO) Valuation After Recent Share Price Weakness
Melco Resorts & Entertainment (MLCO) has been drawing attention after a period of weaker share performance, with the stock down over the past month and past 3 months. This has prompted closer scrutiny of its current valuation. See our latest analysis for Melco Resorts & Entertainment. At a latest share price of $5.38, Melco Resorts & Entertainment has seen its 7 day share price return fall 2.71% and its year to date share price return decline 28.36%, while the 5 year total shareholder return...
The Vanderpump Hotel opens in Las Vegas with a completely fresh look
Entrepreneur Lisa Vanderpump launches her first Strip resort in May at the property formerly known as The Cromwell.
Universal Orlando Executive Reveals Vision for Future of Epic Universe Theme Park
Universal Orlando Resort's Epic Universe is focused on enhancing visitor experiences. Executive Jeff Polk emphasizes careful experimentation over rapid changes, ensuring guest experience balance. There's a future possibility for annual passes, prioritizing passholder experience.
Temporary casino to open as work begins on new Naskila Casino Resort
A groundbreaking ceremony will be held June 18 for the new Naskila Casino Resort near Livingston.
How to Tell if a Wellness Retreat Is Legit Before You Spend Thousands and Some Red Flags
From IV drips to biometric testing, luxury wellness resorts are blurring the line between spa and medical clinic.
Over 20 Aspen businesses plan to shut down in some capacity for 2027 airport closure
Aspen Chamber Resort Association presented to the Aspen/Pitkin County Housing Authority Board Wednesday on potential impacts to the workforce during the 2027 Aspen/Pitkin County Airport closure to help guide initial conversations about waiving required work hours for employee housing.
Las Vegas ranked No. 2 among North America’s top convention cities
Las Vegas was second, and three local resort hotels ranked in the top 10 for best destinations for a convention or meeting in 2025.
Alleged unsafe conditions | Lancaster County woman suing Hershey Entertainment and Resorts
A Lancaster County woman is suing Hershey Entertainment and Resorts, claiming she was injured when a glass panel fell on her during a Hershey Bears game.
Hershey Entertainment denies responsibility for woman's injuries at Hershey Bears game
The suit was filed Monday against Hershey Entertainment & Resorts, the company that owns the Giant Center.
Sports Illustrated Resort set to break ground in Tuscaloosa
The SI Resort project is set to officially break ground May 27.a
Casino operator Jacobs Entertainment celebrates $400M completion in downtown Reno
Jacobs Entertainment officials were joined Monday by local dignitaries and community leaders to celebrate the completion of J Resort's $400 million, five-year p
55-Story Tower could become Reno’s tallest building in J Resort plans
The celebration took place in the property's new 4th Street expansion.
Zarna Garg is ready to make Las Vegas audiences laugh
The internet star performs at The Venetian Resort on May 23.
Don’t Call It A Fat Farm: Hilton Head Health Celebrates 50 Years
Over the past several decades Hilton Head Health evolved into a wellness resort that includes programs on nutrition, movement, mindset, stress recovery and exercise.
Employees at some Hershey Entertainment and Resorts properties reach deal
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Employees at some Hershey Entertainment and Resorts properties reach deal
HERSHEY, Pa. (WHTM) — Union workers at two Hershey Entertainment and Resorts properties agree on contracts, but negotiations continue as of Friday at three others, the company said. The two p…
Howard Community College Featured in 'State of Business' Address
In his Business Outlook Luncheon remarks at Turf Valley Resort last week, Howard County Executive Calvin Ball outlined how Howard County “stands on business” through five pillars: managing crises, investing in people, backing businesses, making strategic investments, and preparing for the future. Howard Community College appears by name in the pillar that anchors the others: investing in people. Dr. Ball highlighted the $11 million county investment in HCC’s Cathy and Danny Bell Workforce and Trades Center, which will open this fall. He described the facility as a world-class center with state-of-the-art training in key industries, championed by HCC President Dr. Daria J. Willis, and positioned to help Howard County compete with institutions worldwide. He also recognized HCC’s Complete4Success program, supported by a $3.5 million county investment in 2022, as a continuing driver of certifications and degrees that prepare students to enter Howard County’s workforce ready to contribute on day one. Dr. Ball connected HCC’s work to the broader economic moment in the county, including more than 1,580 apprentices now training across Howard County businesses, up from roughly 1,100 in 2018, and the SPARK program that bridges classroom learning to high-demand industries. Each of these efforts depends on the kind of workforce pipeline HCC is built to deliver. Educational Services is one of the top three employment sectors for county residents, alongside Professional, Scientific, & Technical Services and Health Care & Social Assistance. HCC will award 1,263 degrees next week at its annual commencement ceremony, and every year, that output feeds directly into the industries the County Executive named as drivers of Howard County’s growth. The full picture also includes the families who are not yet there. The 2024 ALICE update from United Way of Central Maryland found that 35,346 households in Howard County, 29% of the total, fell below the ALICE Threshold in 2022, meaning they earned more than the Federal Poverty Level but less than the basic cost of living in the county. The Household Survival Budget for a Howard County family of two adults, an infant, and a preschooler reached $118,608 annually, requiring an hourly wage of $59.30 to cover housing, child care, food, transportation, and other essentials. Affluence and economic strain coexist within the same county lines. That gap is the reason higher education and economic development are inseparable. Every certification, associate degree, and apprenticeship credential issued at HCC represents a household closer to crossing the ALICE Threshold and into long-term financial stability. The Bell Center, Complete4Success, Howard P.R.I.D.E., Parent Scholars, and the institution’s transfer-rate gains are significant components of Howard County’s economic mobility infrastructure. HCC is grateful to Dr. Ball for his sustained partnership over nearly eight years of service and for recognizing that this college plays a central role in the economic story Howard County is telling. Standing on business in Howard County means standing alongside the flagship institution that prepares its workforce.
Accounts in Transit: Rosen Group Picks Up Kustom Entertainment
Rosen Group to bolster media visibility of Kustom Entertainment, a live event production and ticketing technology company....LDPR lands AOR duties for Windjammer Landing Resort & Residences, a Caribbean resort set along the shores of Labrelotte Bay in St. Lucia....Vitamin, a Baltimore-based shop, picks up The Mood Center, a mental health practice specializing in neurotherapy treatments for depression and related conditions.
[Form 4] Melco Resorts & Entertainment LTD Insider Trading Activity
Stock Titan provides an ultra-fast stock market news feed and multiple tools for traders and investors.
[Form 4] Melco Resorts & Entertainment LTD Insider Trading Activity
GALANTE FRANCESCA reported acquisition or exercise transactions in this Form 4 filing.Melco Resorts & Entertainment LTD director Francesca Galante received a compensation grant of 97,767 ordinary shares on May 8, 2026.
Wall Street Bets: DraftKings, Wynn Resorts, Inspired Entertainment, Genius Sports
David Bain of Texas Capital Securities on May 11 examined DraftKings:
Melco Resorts & Entertainment (NASDAQ:MLCO) Upgraded by Wall Street Zen to Buy Rating
Wall Street Zen raised shares of Melco Resorts & Entertainment from a "hold" rating to a "buy" rating in a research note on Monday.
Iranian businesses said resorting to mass layoffs amid wartime economic struggles
According to New York Times, business leaders warn 3.5 million industrial jobs at risk, several tech firms shut down due to internet blackout, with others laying off hundreds
Colorado governor signs $47 billion budget in which ‘nobody won’
Gov. Jared Polis on Friday officially signed a $46.87 billion spending plan for the Colorado state government in the next fiscal year. His signature is the culmination of months of work by legislators, who resorted to cuts, transfers and other mechanisms to balance the 2026-27 budget amid a deficit of more than $1 billion. That […]
Primm business owners, travelers react to closures of casinos, gas stations
Multiple Primm casino-resorts, two I-15 gas stations, and the Lotto Store are set to permanently close July 4, impacting 344 employees, notice says.
Melco Resorts & Entertainment Publishes 2025 Sustainability Report Highlighting Environmental and Community Initiatives
Melco Resorts & Entertainment released its 2025 Sustainability Report, highlighting environmental achievements and community engagement initiatives.Quiver AI SummaryMelco Resorts & Entertainment has released its 2025 Sustainability Report, titled “RISE to Go Above & Beyond,” highlighting advancements in environmental stewardship, community engagement, and corporate governance. Chairman and CEO Lawrence Ho emphasized the integration of sustainabil
Melco Resorts & Entertainment (NasdaqGS:MLCO) Margin Rebound Tests Bullish Earnings Narratives
Melco Resorts & Entertainment (NasdaqGS:MLCO) heads into its Q1 2026 update with recent quarterly numbers that put revenue at about US$1.3b in Q4 2025 and basic EPS at US$0.16. This caps off a year where trailing twelve month EPS reached US$0.46 on revenue of roughly US$5.2b. Over the past few quarters, the company has seen revenue range between US$1.2b and US$1.3b per quarter, while basic EPS moved from US$0.08 in Q1 2025 to US$0.19 in Q3 before landing at US$0.16 in Q4. This result comes...
Thousands of workers credited as Hard Rock’s Guitar Hotel hits major milestone
The Strip’s largest resort construction project hit a major milestone Friday morning as the final structural beam was placed atop the Guitar Hotel Las Vegas.
Texas Wine Auction supports Hill Country mental health
The fourth annual Texas Wine Auction supporting the Texas Wine Auction Foundation is taking place this weekend at Carter Creek Winery Resort & Spa, featuring live music, a silent auction, dinn…
Melco Resorts & Entertainment Limited (MLCO) Releases Q1 2026 Earnings: EPS Up, Revenue and Gross Profit Down
Melco Resorts & Entertainment Limited (MLCO) reported Q1 2026 results with notable swings across revenue, profitability and cash flow.Total revenues: $1.4 billion (down 44.55% year-over-year).Gross profit: $513.2 million (down 84.15% year-over-year).Operating profit: $179.0 million (up 23.54% year-over-year).Net income attributable to common shareholders: $76.8 million (up 136.17% year-over-year).Diluted earnings per share: $0.20 (up 150.0% year-
Kentucky Derby Day fun comes to Cape Cod bars, breweries and resorts
From fancy hats to mint juleps, Cape Cod bars, breweries and resorts are throwing Kentucky Derby Day parties on May 2.
MGM Resorts' quarterly profit misses estimates amid slower Las Vegas business
MGM Resorts International missed Wall Street expectations for first-quarter profit on Thursday, hurt by weaker performance of its Las Vegas businesses amid ongoing macroeconomic uncertainty.
Peek inside Cache Creek Casino Resort, where gaming meets getaway
Since its humble beginnings as a bingo hall in 1985, Cache Creek Casino Resort, owned and operated by the Yocha Dehe Wintun Nation in Brooks, California, has become one of Northern California's largest casino-resort destinations.
Ocean Casino Resort unveils $20M upgrades for summer entertainment
Among the additions is a temporary “America’s Birthday Bar” planned for June at the resort’s 1927 Lounge.
M Resort tower’s December opening boosts 1st-quarter earnings for Penn Entertainment
CEO Jay Snowden also says higher gasoline prices haven’t affected casino visitation yet, likely because tax refunds have been higher than they’ve been.
Penn Entertainment CEO Snowden touts 'strong execution' for largest quarterly increase in three years
It’s fair to say Penn Entertainment CEO Jay Snowden is bullish on the company’s recent performance. During Thursday’s first quarter earnings call, Snowden noted visitation rates at brick-and-...
Penn Entertainment reports revenue of $1.4 billion for the first quarter of 2026
Penn Entertainment on Thursday morning reported revenues of $1.4 billion for the first quarter of 2026. Segment Adjusted EBITDAR was $471.4 million. “We are pleased to report another solid qua...
With Midterms Coming Up, G.O.P. Is Bogged Down in Congress
Republican majorities are at odds on big issues as the Senate resorts to extraordinary measures to pass homeland security funding over a Democratic blockade.
Ocean Casino Resort Unveils Summer 2026 Lineup with High-Energy Entertainment, New Openings, Expanded Private Jet Service and Seasonal Amenities
/PRNewswire/ -- Ocean Casino Resort is setting the stage for an unforgettable Summer 2026 with an exciting lineup of headlining entertainment at HQ2 Beachclub...
QCI strategic partnership with SkyCity Entertainment integrates brick-and-mortar with other aspects of resort
SkyCity Entertainment Group in New Zealand, a casino and hospitality company, has expanded a strategic partnership with Quick Custom Intelligence. The goal was to build a more connected, enterprise...
Caesars Entertainment Unveils Summer Savings at Las Vegas Resorts
Caesars Entertainment announced summer savings at eight Las Vegas resorts, including up to 50% off stays, suite discounts, daily food-and-beverage credits, and bundled hotel packages.
Summer Savings Starts Now: Caesars Entertainment’s Las Vegas Resorts Introduce More Value Options
LAS VEGAS, April 20, 2026--Caesars Entertainment is starting summer early with an expansive collection of travel, dining, spa and entertainment deals across its Las Vegas resorts. Highlights include new, limited-time hotel offers launching today, April 20.
Summer Savings Starts Now: Caesars Entertainment’s Las Vegas Resorts Introduce More Value Options
Caesars Entertainment is starting summer early with an expansive collection of travel, dining, spa and entertainment deals across its Las Vegas resorts. High...
The Sphere in Las Vegas is only the first. Where are they opening next?
(NEXSTAR) – The Las Vegas Sphere is just the first of many round, bulbous entertainment venues that the venue’s operators are hoping to open. The first Sphere, located near the Venetian Resort off the...
Sports Illustrated resort to open in Nashville
Travel + Leisure Co. said the resort is set to welcome its first members and guests in Spring 2026 and will be located on Music Row.
Sports Illustrated Resorts brand expands to Louisiana college town
Developers will convert a Hilton hotel in Baton Rouge under the lifestyle brand amid Sports Illustrated Resorts’ expansion into premier sports-driven college and university markets.
Hershey Entertainment & Resorts Celebrates Earth Day 2026
All year in Hershey, Pa., we celebrate what matters most: our planet Earth! Hershey Entertainment & Resorts (HE&R) is dedicated to reducing our environmental footprint with the support of our guests and team members. Thanks to HE&R's initiatives, the company successfully conserved the following resources in 2025:
Sports Illustrated Resorts Announces New Resort Destination Near LSU in Baton Rouge
ORLANDO, Fla.--(BUSINESS WIRE)--Apr 15, 2026--
Sports Illustrated, Shaq opening a sports fan-focused leisure resort in downtown Baton Rouge
SI announced plans to bring immersive sports hospitality, premium lodging, and year-round fan experiences
GOP senator sues to block takeover of family's historic resort amid $289M debt dispute
A legal battle over the Greenbrier resort intensifies as the Justice family accuses creditors of deceptive tactics, while an investor alleges fraud and financial mismanagement.
Assessing Six Flags Entertainment (FUN) Valuation After Its Recent Name Change And Share Price Rebound
Why Six Flags Entertainment Is Back On Investors’ Radar Six Flags Entertainment (FUN) has been reshaped by its July 2024 name change from Cedar Fair, putting fresh attention on a business that runs amusement parks, water parks, and resorts across North America. See our latest analysis for Six Flags Entertainment. Recent trading has been lively, with a 30 day share price return of 22.89% and a 90 day gain of 25.00%. However, the 1 year total shareholder return of 38.98% and 5 year total...
BETMGM Q1 2026 BUSINESS UPDATE
BetMGM LLC ("BetMGM"), a leading sports betting and iGaming operator across North America, jointly owned by MGM Resorts International (NYSE: MGM) ("MGM Resorts") and Entain plc (LSE: ENT)...
4 shows to see in the Coachella Valley this weekend
Mariachazo will perform on Friday at Fantasy Springs Resort Casino.
Comedian Sebastian Maniscalco set for Turning Stone show
Comedian Sebastian Maniscalco will perform April 18, 2026, at Turning Stone Resort Casino in Verona as part of his national tour.
News Splash: Jefferson Health Teams Up With Kalahari Resort for Health and Wellness
Collaboration with iconic Pocono attraction provides benefits for both resort employees and guests
Dollywood discounts are here for the park and resorts. See who qualifies
Dolly Parton’s theme park has discount tickets and special rates for resort stays for community heroes. But the offer is only for a limited time.
Mohegan Names Joe Soper VP, Sports & Entertainment
Casino and resort developer Mohegan has announced the appointment of Joe Soper as VP of Sports & Entertainment, where he will oversee strategy and
ASUS Resorts To Deceptive Practices, Raises The Prices Of Its Snapdragon X2 Elite Laptops Shortly After Reviews Go Live
Almost immediately after views of ASUS’ Snapdragon X2 Elite Extreme and Snapdragon X2 Elite laptops went live, the company raised prices
GRATON RESORT & CASINO ANNOUNCES APRIL PROMOTIONS, ENTERTAINMENT, AND MAY 4 EXPANSION OPENING
This spring marks the start of a new era at Graton Resort & Casino. On May 4, the resort will unveil the next phase of its expansion, introducing new dining, entertainment, and gaming experiences. At the heart of the expansion is a new 144,000-square-foot, fully smoke-free gaming floor, creating a more spacious and comfortable environment for guests while expanding Graton’s…
Foley Entertainment Group, hotels appoint sales, marketing leaders
A number of hotels—as well as Foley Entertainment Group—have appointed sales and marketing leaders in recent weeks. | Hotels and resorts across the country have new sales and marketing leaders.
Melco Resorts officer uses 32,619 shares for taxes
Melco Resorts & Entertainment officer Akiko Takahashi delivers 32,619 ordinary shares at $1.89 each for tax withholding, retaining over 2.07M direct shares plus 210,675 held via a 2022 GRAT.
How Investors May Respond To Melco Resorts & Entertainment (MLCO) Liquidity Jitters Amid Premium Macau Push
In recent weeks, Melco Resorts & Entertainment reported mixed fourth-quarter 2025 results, while major banks including BofA Securities, UBS, and Morgan Stanley updated their research views on the company amid concerns over liquidity, margins, and Macau market conditions. At the same time, Melco underscored its premium positioning by highlighting eight MICHELIN Stars across five Macau restaurants, reinforcing how high-end non-gaming offerings are becoming a central part of its hospitality and...
A Look At Melco Resorts & Entertainment (MLCO) Valuation After Recent Analyst Downgrades And Earnings Miss
Recent shifts in analyst sentiment toward Melco Resorts & Entertainment (MLCO) have put the stock in focus, after several major banks flagged slower expected Macau EBITDA growth, liquidity questions, margin pressure, and mixed quarterly results. See our latest analysis for Melco Resorts & Entertainment. At a share price of US$5.68, Melco Resorts & Entertainment has seen a 1 day share price return of a 1.56% decline and a 90 day share price return of a 24.37% decline. The 1 year total...
Central Oregon’s Mt. Bachelor resort gets into the hotel business
"Right place, right time" led the resort to jump on a long-term lease on the road to its lifts.
Caesars Entertainment launches inclusive summer package at 3 Las Vegas properties
Caesars’ announcement follows a similar move by MGM Resorts, which introduced an all-inclusive package in March for two of its Las Vegas properties.
Caesars Entertainment the Latest to Offer All-Inclusive Packages for Las Vegas Hotels
Caesars Entertainment is offering its guests summer value options with the launch of its Inclusive Summer Package, a bundled hotel experience at Harrah’s L | The package includes accommodations, taxes, resort fees, two meals per day at dining outlets, bottomless drinks, High Roller Observation Wheel tickets and free self-parking.
Scott Pemberton O Theory added to VanWood entertainment line up
SOUTH LAKE TAHOE, Calif. – VanWood Tahoe, hosted by the Boys & Girls Club of Lake Tahoe in partnership with Kirkwood Mountain Resort and EpicPromise, announced a featured live music experience as part of its inaugural...
4 shows to see in the Coachella Valley this weekend
John Legend will perform on Saturday, April 4, at Fantasy Springs Resort Casino in Indio.
MGM Resorts offers new all-inclusive option, including meals and entertainment!
Las Vegas remains one of the most sought-after travel destinations in the country, attracting millions of visitors each year for headline concerts, professional
The Race to Succeed Newsom Has All the Democrats’ Problems
After more than a year in disarray, Democrats finally seem to be getting it together. The party is heading into the midterm elections with an edge in both polling and messaging. Voters are energized — see this weekend’s No Kings rallies — and that has led to a string of wins in special elections, including one last week that flipped a district in Florida that takes in President Donald Trump’s Mar-a-Lago resort.
World of Frozen Opens at Disneyland Paris’ New Disney Adventure World
New Frozen-themed land headlines major expansion at Europe’s iconic Disney resort.
Frontdoor, American Airlines, Viking, MGM Resorts, and Caesars Entertainment Stocks Trade Down, What You Need To Know
What Happened? A number of stocks fell in the afternoon session after the latest University of Michigan survey revealed a sharp drop in consumer sentiment to...
Implied Volatility Surging for Melco Resorts & Entertainment Stock Options
Investors need to pay close attention to MLCO stock based on the movements in the options market lately.
DOJ sues SeaWorld’s parent company over ban on wheeled walkers at their parks
Tthe department asked for a jury trial in Orlando to determine if United Parks & Resorts has violated the Americans with Disabilities Act
Hershey Entertainment & Resorts Celebrates 2025 Partners of the Year
Hershey Entertainment & Resorts (HE&R) recently named its 2025 Partners of the Year at Town Hall meetings across several properties. Throughout the 2025 calendar year, team members were nominated by their peers or supervisors for “Team Member of the Month” recognition for embodying HE&R's Core Values: Devoted to the Legacy, Selfless Spirit o...
Pullman Danang Beach Resort Responds to Rising Bleisure Travel with Expanded Business and Leisure Facilities
/PRNewswire/ -- As global travel patterns continue to evolve, "bleisure" travel, which combines business trips with leisure experiences, has become a...
Democrat flips seat in special election for Florida district that includes Trump’s Mar-a-Lago resort
Democrat Emily Gregory has won a special election for a Florida state House seat, flipping a district that is home to President Donald Trump’s estate, Mar-a-Lago
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. 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2 Arizona resorts, Hawaiian BBQ spot cited by health inspectors
Two Arizona resorts and one Phoenix Hawaiian BBQ spot were among places cited by health code inspectors in this week's Dirty Dining report.