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Why workflow accountability may define healthcare AI's next phase
Oracle Health chief architect Manu Agrawal explains why healthcare-specific AI must be grounded, auditable and tailored to the risk of each workflow.
UNC Health Launches UNC Health Ventures, Marking Next Phase of Strategic Investment Platform
New initiative builds on Rex Health Ventures’ legacy to advance system-wide innovation, partnerships and long-term value.
Hubble Solves Merger Mystery From Milky Way’s Early Years
New Hubble data shows definitive evidence of a dwarf galaxy merging with the young Milky Way in the earliest phases of its evolution.
PENN Entertainment to move an additional riverboat casino to dry land
The gaming/entertainment company has announced it will phase out another riverboat casino in favor of a new landside property in New Orleans.
Nashville's statement, Houston's surge & more from Matchday 20
By Charles BoehmThe days are growing shorter, and the kids are going back to school. The FIFA World Cup is in the rearview mirror, and so is Phase One of Leagues Cup.You might not have heard a starter...
Dodgers Expect Ohtani Back on the Mound in September
Shohei Ohtani enters the final phase of his throwing progression, aiming to bolster the Los Angeles Dodgers rotation before the postseason begins.
Microsoft confirms that it will begin shipping major Windows 11 Taskbar and Start menu updates in the next few weeks: Big OS update enters final preview phase before public rollout begins
The ability to move and resize the Taskbar, as well as customize the size and layout of the Start menu should begin rolling out imminently, if the latest Windows 11 preview builds are anything to go by.
Pace appoints Andy Fenny as president to drive life science growth
Pace, a science and technology company, has appointed Andrew (Andy) Fenny as president of Pace Life Sciences, the organization’s life sciences division, to lead the business into its next phase of strategic growth with a focus on expanding support and capacity for pharmaceutical and biotech clients across the development cycle.
Kodak's Transformed Business Has Improved for Four Straight Quarters
Kodak reenters a growth phase.
Starting QB Revealed for Browns Preseason Opener with Bears
The Cleveland Browns QB competition reaches it's next phase as the team faces the Chicago Bears in their preseason opener. But who will start?
Casper City Council plans financing for final phase of business center remodel
CASPER, Wyo. — City officials discussed financing options for the final phase of the ongoing Casper Business Center remodeling project on Tuesday, with
California to phase out paraquat, a powerful weedkiller associated with serious health issues
The California Department of Pesticide Regulation said all manufacturers of pesticide products containing paraquat have "voluntarily canceled" their product registrations.
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
VIDEO: Kilauea Volcano Update, Lava Fountain Science
HAWAIʻI VOLCANOES NATIONAL PARK – Scientists examine how lava chemistry correlates with higher lava fountains, and they are wondering if Kīlauea might be in a growth phase.
Strengthening Indonesia’s health emergency response through after action review of disaster response in Aceh, North Sumatra and West Sumatra
Severe floods and landslides that struck Aceh, North Sumatra and West Sumatra in late 2025 exposed both the strengths and gaps in Indonesia’s health emergency response, prompting a nation-wide effort to strengthen preparedness for future crises. In the early phase, the scale and speed of the crisis challenged coordination, data systems and surge capacity. To assess the response, the World Health Organization (WHO) Indonesia supported the Ministry of Health’s Center for Health Crisis in conducting a multi-stakeholder after-action review (AAR). The review brought together government agencies, health sub-clusters, NGOs, and partners. “The AAR is a critical process for strengthening our collective response capacity,” said Agus Jamaludin, Head of the Center for Health Crisis at the Ministry of Health. “It provides valuable lessons not only for the Health Crisis Center but also for all stakeholders involved and serves as an important reference for improving future responses across regions.” After Action Review (AAR) brought together key stakeholders to reflect on the emergency response, identify lessons learned, and strengthen preparedness for future health crises. (WHO/Resty Armis)Through structured discussions across four pillars – leadership and governance, information-based decision-making, service delivery and resource management – the AAR identified several strengths. These included the rapid mobilization of national surge capacity, such as health reserve workforce (tenaga cadangan kesehatan) and emergency medical teams (EMT) and the continued provision of essential health services in affected areas. At the same time, the review highlighted challenges. Among them were uneven functionality of Health Emergency Operation Center (HEOC), fragmented early data reporting and reactive logistics deployment. The findings informed five strategic priorities for strengthening the system, including HEOC standardization, integration of the One Crisis Data system, establishing disaster-resilient hospitals and reforming surge capacity mechanisms. The AAR demonstrates that Indonesia’s health emergency response has strong foundations but requires system-level strengthening to shift from reactive to proactive preparedness. By mainstreaming the strengths and recommendations identified, Indonesia can build a faster, more coordinated and more resilient health system – better equipped to protect communities during future crises. Written by Lintang Sibarani, NPO Emergency and Humanitarian Actions, WHO Indonesia
As GTA 6 publisher Take-Two revises its 2027 net bookings up to $8.2bn, Strauss Zelnick confirms its sales are "well over 90% digital"
First Capcom, now Take-Two: Strauss Zelnick doesn't appear phased by PlayStation's migration to an 'all-digital future'.
Court orders Meta to pay $567M to address kids' mental health online
The order came in the second phase of a landmark trial Meta lost in March.
What happened at Browns training camp? Day 8 live updates
The Browns have reached Day 8 of training camp, the final phase of the install process. Follow here for updates throughout.
VA accelerates electronic health record rollout
After years of delays, the Department of Veterans Affairs says its federal electronic health record (EHR) program is now firmly back on track. VA Secretary Douglas Collins has accelerated the program with a renewed goal: full deployment across all VA medical centers by 2031. A major governance overhaul, replacing multiple competing councils with a single decision-making body, has cut through bureaucratic delays and allowed the VA to move faster and more consistently. Deputy Secretary Paul Lawrence has taken a hands-on role, including visiting deployment sites and holding daily meetings with Oracle Health to ensure front-line clinicians have what they need. Here’s how the rollout is going, according to the VA: The federal EHR has only experienced four outages since December 2025. The system has gone nearly two consecutive years without a major incident. It is currently live at six sites, supporting care for over 188,000 veterans. The system creates a lifelong medical record, integrating data across the VA, the Department of Defense and private community providers. With the first new deployments underway and four Michigan medical centers already live in 2026, the VA is entering its first true expansion phase since the program’s reset. Officials say the system’s improved stability, streamlined governance and standardized national workflows have cleared the obstacles that once stalled progress. With 13 sites scheduled for deployment in 2026 and a market‑based rollout strategy guiding future waves, the department believes it’s finally positioned to move at scale toward a modern, fully interoperable EHR, advancing steadily toward its goal of reaching every VA medical center in five years.
Sanofi suspends chronic lung disease phase 2 study, tied to ‘strategic business reasons’
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce Biotech has learned. The trial, which began only back in April, was a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score following treatment with SAR445399 compared with placebo in adults aged 18 to 80 years with NCFB, a chronic lung disease. The trial was officially reported as halted on July 29, the day before Sanofi’s second-quarter earnings call. The decision to pause the trial was made “as part of a company-wide portfolio review for strategic business reasons,” and not due to safety concerns, a Sanofi spokesperson told Fierce. The move to pause the NCFB trial comes during a trying time for Sanofi following a year filled with a series of trial fails. In February, the French pharma ousted CEO Paul Hudson and appointed Merck KGaA leader Belén Garijo, M.D., Ph.D., to steer the ship. Since then, Garijo has been doing a deep dive on correcting the company’s strewn R&D and clinical strategies. On July 24, Sanofi scrapped amlitelimab for atopic dermatitis, despite its lore as being a potential $5 billion blockbuster. During its second-quarter report, the company abandoned two more assets, balinatunfib and itepekimab, following failed trial results in psoriasis and chronic obstructive pulmonary disease, respectively. SAR445399, only first revealed by Sanofi in 2023, is an anti-interleukin-1 receptor 3 monoclonal antibody developed to block the interleukin 1, 33, and 36 cytokine pathways. These pathways can be important in chronic immune-related dermatologic diseases, such as atopic dermatitis and hidradenitis suppurativa, as well as respiratory conditions, such as NCFB. Related Sanofi’s new CEO ‘looking deeply’ at late-stage pipeline as clinical clearout continues NCFB affects roughly half a million people in the U.S., with a global incidence of greater than one million cases. In August 2025, Insmed received FDA approval for Brinsupri, a DPP1 inhibitor targeting neutrophil activation, for treatment of NCFB in adults and kids ages 12 and older. The British biotech Infex Therapeutics showed promising NCFB phase 2a data using their monoclonal antibody, INFEX702, which acts by disabling Pseudomonas aeruginosa, a bacteria known to be a major pathogen of NCFB. Sanofi is currently running a separate phase 2 study testing SAR445399 as a potential treatment for the inflammatory skin condition hidradenitis suppurativa.
Convention Center Launches WIN Phase 2 Series With Construction Services Small Business Workshop
The New Orleans Ernest N. Morial Convention Center (NOENMCC) is continuing its commitment to small and emerging businesses throughout the year with the next installment in its WIN Series. The next phase of workshops, The Procurement Playbook, focuses on construction and vendor service businesses throughout Greater New Orleans. The WIN Series is a part of
Bypass will slash congestion, claims business case
Phase one of Hereford bypass is forecast to cut traffic by up to 25%.
Fountain Square businesses plead for support as $14M project enters final phase
A $14 million drainage project in Indianapolis's Fountain Square neighborhood aims to reduce flooding, though local business owners report significant losses in foot traffic and sales during the ongoi...
Steps announced to improve public safety in Chippewa Entertainment District
In a Tuesday press conference at Buffalo City Hall, Mayor Sean Ryan was joined by fellow city and business leaders to announce the next phase of his administration’s efforts to improve public safety in the Chippewa Entertainment District after several weeks of enhanced enforcement and evaluation. Read more from WBEN: | WBEN
Galaxy Z Fold 8 destroys pre-order record set by the late Note 10, and it isn’t over yet
Samsung’s Galaxy Z Fold 8 series, alongside the Flip 8, has broken 1.44 million sales during the pre-order phase, smashing...
Buffalo: Ryan announces steps to improve public safety in Chippewa entertainment district
Mayor Sean Ryan announced the next phase of his administration's efforts to improve public safety in Buffalo's Chippewa entertainment district following several weeks of enhanced enforcement and evaluation.
Princeton Engineering - Federal investment of $18 million builds on three decades of advances in materials science
The Princeton Center for Complex Materials (PCCM), a research center at Princeton University dedicated to pushing the frontiers of materials science, has been selected by the National Science Foundation (NSF) for renewed investment to build on its success in research, workforce development and public outreach
Canada's Enbridge postpones plans for second phase of Mainline oil pipeline expansion
Canadian pipeline operator Enbridge said on Friday it was postponing the 250,000-barrel-per-day second phase of its Mainline crude pipeline network, partly due to Canadian oil producers not committing to significant output increases.
[AIDS 2026] Health Policy Watch: Adjusting to a post-PEPFAR world
Many African PEPFAR-funded countries had developed sustainability plans to integrate HIV services into primary healthcare to be phased in over five years.
iPhone 18 Pro: Twelve Changes Coming to Apple's Next Flagship
We're less than two months out from the launch of Apple's premium next-generation smartphone lineup, and while we're not expecting a dramatic change in terms of functionality, there are still several enhancements rumored to be coming to the iPhone 18 Pro and iPhone 18 Pro Max. One thing worth noting is that Apple is reportedly planning a major change to its iPhone release cycle this year, adopting a two-phase rollout starting with the iPhone 18 series.
Inside Stefanos Tsitsipas’ Love Story With Girlfriend Kristen Thoms
Stefanos Tsitsipas of Greece entered a new phase of life with his American girlfriend Kristen Thoms.
Knox Community Hospital signs non-binding letter of intent to join Kettering Health
MOUNT VERNON – Knox Community Hospital announced today it has signed a non binding letter of intent to join Kettering Health, a non-profit healthcare system in western Ohio. The agreement begins the next phase of a process focused on strengthening local access to care and investing in Knox Community Hospital’s future. “Throughout this evaluation, our […]
On Air and Online: Spectrum Business Powers Globecast Americas’ Broadcast Evolution
Working with Globecast during the relocation planning phase, Spectrum Business helped design a network foundation that could keep content moving quickly, securely and reliably from day one.
Galveston businesses ask for I-45 construction delay
Concerned about the effect on businesses during the final weeks of Galveston’s peak tourism season, the Galveston Restaurant Group has asked the Texas Department of Transportation to delay Phase 2,
Hobart and William Smith Colleges gets $3 million for science center
GENEVA — Hobart and William Smith has been awarded a $3 million Higher Education Capital Matching Grant Program grant from New York State to support the next phase of the
Michael Rattray & Robert Kiel: How Science Is Trying to Restore Santa Barbara’s Lost Kelp Forests
The Beach Erosion Authority for Clean Oceans and Nourishment (BEACON) unanimously approved the next phase of the Goleta Bay Kelp Project on July 17. This
Temporal Changes in Pediatric Influenza Test Positivity Across COVID-19 Public Health Policy Phases: A Five-Year Retrospective Cohort Study
Background The COVID-19 pandemic coincided with substantial changes in respiratory virus circulation, healthcare utilization, and diagnostic testing. Although population-level influenza activ...
Major changes coming to Choate Mental Health and Developmental Center in Anna
The Illinois Department of Human Services outlined plans to reduce residential units serving people with intellectual and developmental disabilities and to phase down mental‑health beds.
Berkeley Lab to Lead 13 New Genesis Mission AI Projects
Researchers will apply AI, supercomputing, and advanced instruments to accelerate discoveries for energy, science, and national security.
DOE Genesis Mission awards will advance AI-driven science
Two Cornell-led research teams have been selected to receive nearly $1.2 million through Phase I of the U.S. Department of Energy’s Genesis Mission.
Nevada health officials brace for new Medicaid work requirements
Nevada health officials are preparing to phase in sweeping new work requirements for the largest safety-net insurance program in the state, a move that will impact an estimated 280,000 Nevadans who benefited from expanded Medicaid coverage.
Stanford and SLAC to lead Genesis Mission projects
The U.S. Department of Energy announced the first phase of funding for projects using artificial intelligence to tackle the nation’s most complex science and technology challenges, including six led by Stanford and SLAC National Accelerator Laboratory.
Foxconn Ramps Up Hiring as iPhone 18 Pro Enters Mass Production
Apple's iPhone 18 Pro models have entered mass production and are now in a production ramp-up phase, according to China Securities News. In a new report citing industry chain sources (via MyDrivers), Apple's main assembly partner Foxconn is said to have entered its peak recruitment period to prepare for large-scale production and stocking ahead of the fall launch. Hourly wages, base pay, and rehire bonuses have all been raised to attract workers amid the ramp-up.
Devonian’s Phase II/III Thykamine paediatric study secures Health Canada approval
Devonian Health Group has received authorisation from Health Canada for its CTA to begin a Phase II/III study of Thykamine cream to treat mild-to-moderate atopic dermatitis in paediatric patients.
What to watch for in Arizona tonight: From the Politics Desk
Plus, an uncertain new phase of the Iran war.
Multi-Restaurant and Entertainment Concept The Forge Begins Soft Opening in Midtown Ocala
The Forge has officially entered its soft opening phase, with six restaurant concepts now open and additional businesses planned in the coming weeks and months.
Delaware Gov. Matt Meyer bans private equity purchases of hospitals, signs bills to improve health care access, affordabilit
Senate Majority Leader Bryan Townsend says his legislation phases in price caps on hospitals and strengthens primary care access.
Caesars Entertainment (CZR) Following Lake Tahoe Relaunch Has Fair Value Back In Focus
Caesars Entertainment (CZR) has drawn fresh investor attention after unveiling Caesars Republic Lake Tahoe Hotel & Casino and completing a multi phase refresh of the former Harveys Lake Tahoe with updated rooms, gaming, dining and entertainment. See our latest analysis for Caesars Entertainment. Recent events, including the Lake Tahoe relaunch and a board resignation announcement, come as Caesars Entertainment’s share price has a 90 day share price return of 9.88% and a year to date share...
Top 10 Mountain West Football Games of the Divisional Era
With the Mountain West changing, I thought it would be fun to go back and highlight the best players, games, and teams since the last phase of conference realignment 13 years ago. Previously, I’ve covered Top 10 football players, Top 10 basketball players, Top 10 Football Teams, and Top 10 Basketball Teams. Today’s list covers […]
Rochester sports complex indoor phase potentially on hold
Plans to bring covered sports facilities to the city may be stopped.
U.S. War Against Iran Enters a New Phase
As President Trump resumes his war, the focus is now on the Strait of Hormuz. But it remains unclear how far the U.S. military will go to exert control.
County business park to get first infrastructure, new name
New Hanover County’s Holly Shelter Business Park could be getting its first infrastructure and a new name in the coming months. The New Hanover County Board of Commissioners unanimously approved a $6.5 million infrastructure construction contract and renaming on Monday. Once developed, the approximately 300-acre master-planned industrial park is expected to accommodate more than 2 million square feet of industrial space. The construction contract was awarded to Carolina Civilworks, which submitted the lowest responsive bid for the construction of the infrastructure, Akin Akinola, the county’s engineer, told commissioners on Monday. In May 2023, the county approved a development agreement with Sidbury Land & Property Company to establish the business park. The firm then conveyed approximately 52 acres to the county, giving officials the option to purchase another 200 acres, Akinola said. “The county’s role is to construct the initial public infrastructure that will make the site ready for future development,” he said. “Today’s contract award represents the first major construction phase of that project.” The first phase of development will include approximately 2,750 linear feet of business park roadway, a water main and fire hydrants, along with a sanitary sewer pump station, sewer force main and gravity sewer. Other infrastructure will include a right-turn lane on Holly Shelter Road, along with associated drainage, utilities and traffic control improvements. “Completing this work establishes the backbone infrastructure necessary to serve future development and positions the site for future economic investment,” Akinola said on Monday. County staff, in consultation with Wilmington Business Development officials, are also recommending renaming the park as the I-40 Coastal Commerce Park, said Jennifer Rigby, the county’s chief strategy officer. The new name would emphasize the park’s proximity to I-40 and its location on the coast, she said. Several county commissioners also asked to add New Hanover County's name to the business park's name to commemorate the county's contributions. “We are hoping to achieve space for our businesses to grow and expand here in New Hanover County,” Rigby said. “We’ve had great success with out Blue Clay Business Park and this is another opportunity to really provide locations for our businesses to grow and expand.”
47 revelatory hours with Assassin’s Creed Black Flag Resynced
To review this month’s supposed remake of 2013’s Assassin’s Creed IV: Black Flag, I must first correct the record. Assassin’s Creed Black Flag Resynced isn’t a game about pirates (and assassins) in the 18th century Caribbean. Sure, sure, that’s what the trailers would have you believe. They’ve go their clips of Edward Kenway swinging his swords and steering his pirate ship into cannon-blasting combat against British frigates. Is Resynced truly a pirate game? Of the 47 hours I spent playing Resynced over the past few weeks, I will admit I spent maybe 44 (?) of them collecting plunder with Blackbeard, drinking rum with Anne Bonny and debating the pros and cons of the lawless pirate-run settlement Nassau with Benjamin Hornigold. I may in fact have spent dozens of hours sailing to remote islands, reading treasure maps, opening messages left in bottles, sinking the odd Man o’ War with a well-timed broadside, collecting sea shanties for my crew, befriending a pet monkey, and hunting whales. I am nevertheless neither so Gullible nor so Narrow-Minded as to call the magnificent Resynced a “pirate remake.” Oh no. Forget any reviews of Assassin’s Creed Black Flag Resynced you may have read. Forget what you yourself may have played, if you’ve spent any time with the game since its launch. What Assassin’s Creed Black Flag Resynced is really about I’m here to give you the scoop (spoilers for Resynced’s Animus menu lore, which many players are probably not going to see): Assassin’s Creed Black Flag Resynced, the new game whose development was led by Ubisoft Singapore, is set in the year 2096. It’s about a societal split, about revolution, about an old Assassin’s Creed adventure repurposed in the series’ distant future as propaganda or samizdat. It’s about the overheated future of 2096, essentially conquered by the series’ well-established nefarious Templar-run company Abstergo. (In this future, Abstergo is, among other things, remaking a 2013 pirate movie called Devils of the Caribbean, but this time in VR. The VR version will be backed by a marketing plan that involves AI influencers, a 10,000-avatar “metaverse premiere event” and that manufacturing of memes aimed at “50 million VR nodes.” See what I mean about Abstergo being evil?) Resynced is about a late 21st-century population mollified by the widespread use of Abstergo’s Animus devices which let people experience the lives of historical figures culled from “genetic memories.” It’s about an insurgent faction of Assassins. And it’s about a plan to wake the population into revolutionary fervor by showing them the memories of 18th century pirate Edward Kenway, who—as depicted in the original Black Flag and again in Resynced—gradually comes to an understanding about the Assassins of his day and their centuries old fight for freedom. Resynced is also about an AI developed within the late 21st-century Animus, called Ego. It has found a way to alter genetic memories, to create and show Animus users false ones. The game is about Ego’s efforts to tell the people experiencing Edward Kenway’s memories that Kenway was wrong, that fighting against order is folly, that we should crave a world where “compliance is rewarded with power.” Who are we in this game? We’re an unnamed Animus user in 2096 who experiences Kenway’s journey virtually. At four moments during Kenway’s exploits in the Caribbean our virtual jaunt can be interrupted for 10-15 minutes, as we explore Animus “rifts” where Ego explicitly tries to tell us how wrong Kenway was. None of this is what 2013’s Assassin’s Creed IV: Black Flag was about, of course. That was a different game, even if you also spent dozens of hours pirating as Kenway in that game, across missions and a map that’s been faithfully reintroduced and rebuilt for Resynced. The 2013 Black Flag was about you playing as an unnamed researcher newly hired in 2013 by Abstergo Entertainment, the video game development wing of the Templars’ evil-corp. In that game, you were assigned to use the Animus to dive into the genetic memories of Desmond Miles, a man who died in Assassin’s Creed III and who was descended from a long line of Assassins (and at least one Templar) whose adventures were featured across the prior AC games. In 2013’s Black Flag, your mission was to plumb the Edward Kenway experience for material that Abstergo could use in productions such as the motion picture Devils of the Caribbean, though the Templars had some ulterior motives for the assignment. Resynced is therefore not a remake of 2013’s Black Flag. It’s a sequel. It is a new game about a new exploration of Edward Kenway’s pirate/assassin journey, set 83 years after the framing sequences of the original game. Resynced provides a new narrative framework that, thanks to the concept of an AI that wants to alter historical memories, arrives with creative justification to tweak a now-classic 13-year old game. That makes Resynced, already a hot seller, a tantalizing hint of where Ubisoft could go with a line of Assassin’s Creed remakes. They could remake the first game, the Ezio games, even the recent ones set in ancient Egypt and Greece. And for each, they could not just modernize the graphics and controls but expand and alter their sequences of events to use them as reference points for a conflict set in the late 21st century, as rival factions try to weaponize historical memories. Game File is a reader-supported publication. To receive new posts and support my work, even when that work consists of ravings about Assassin’s Creed’s modern day plot, please consider becoming a free or paid subscriber. Subscribe A story most players will probably miss If you didn’t know any of this, I’m not surprised. If you played the game and still didn’t catch it, I’m not a bit shocked. If Ubisoft has no plans to do more of this, I won’t fall down. Almost all of what I’ve described is optional and missable in Black Flag Resynced. I nearly missed it myself, as I planned for a breezy playthrough of an old Assassin’s Creed favorite. Instead, I found myself in a 40+ hour hunt for the “real” story, buried deeper in Resynced than any gold-filled chest. The story of 2096 is Resynced’s meta-story, told in two remote pockets of the game: 1) four optional playable “rifts” that players may find as they proceed through Resynced’s pirate fantasy , 2) in dozens of text files tucked three menus deep in the game’s barely-interactive Animus hub. Assassin’s Creed games have almost always had a meta-story about people in the 21st century (usually matching the game’s release year) and their connections to the main history portions you play. Those meta-stories have always been squeezed into the margins, though seldom as severely and as, uh, graphiaclly simple, as in recent games. Back in 2013, the modern-day exploits of you as an Abstergo Entertainment employee were prominent. They were portrayed via first-person portions that occasionally interrupted the third-person Kenway experience and could be explored for hours, complete with their own missions, side quests and puzzles. Resynced’s 2096 story—of Assassin “Watchers” vs. Abstergo/Tempar goons, of rogue AIs, of panicking scientists, of a woman wondering why her Animus-addicted husband is muttering about Mary Read (“What does he mean by Assassins?”), of a fight for the population’s hearts and minds via varying interpretations of Edward Kenway’s life choices—is mostly told through unlockable text files. The files are interesting. Offered via diary entries, intercepted chats and news reports, they present varied perspectives of a world in crisis. One set works as a narrative puzzle as it reveals the Rashomonic interpretations of a massacre, or was that a successful Assassin hit? Another favorite reveals the rising bitterness of a person who, through Edward Kenway’s journey, now shakes at the ignored evil around him. One surmises that Ubisoft is averse to putting the Assassin’s Creed’s meta-story in the way of more marketable pirate playgrounds and ninja/samurai epics. Instead, we get a better-than-nothing text-in-menus approach introduced in 2025’s Assassin’s Creed Shadows. In Shadows, players unlocked the meta-story text files largely via time-gated missions that called on the user to kill X number of enemy type Y, clear three enemy castles, re-win a three-phase fighting tournament, and other grinds. Time restrictions on accessing these missions and unlocking the files meant it could take players months to access the full story in-game. But even in the most hardcore Assassin’s Creed hangouts, the fanbase instead seemed to throw up their hands rather than grind to keep up. In Resynced, Ubisoft has shown some mercy, diminishing the amount of new text files that are tied to timed grinds. Now, most of the text-based 2096 lore are associated with “data file” collectibles that players can find in the world. That includes a batch of written entries that explain a historical link between the feudal Japan era in Shadows and the piracy adventures in Black Flag. Players who explore a lot will find dozens of data files, though the game does not appear to offer any in-game tracker for finding each one. You just need to keep looking for them. As of this writing, I have most of them, but not all. I can’t find any full guide for them online. And even Ubisoft’s optional $5 microtransaction that reveals lots of items in-game does not appear to reveal the locations of the text files (at least the official description omits them from its collectibles list). That’s not a huge bother, because tracking the data files down compelled me to re-explore the waves and islands of Black Flag. That was a thoroughly pleasant task to do for the first time in a dozen years. I expect many players, though, will be content to wait for the files to be reproduced in an online AC wiki somewhere, the easier to read on a web page. It may not seem enticing to play a video game in order to gradually unlock pages of text to read. Why not, you may ask, just read a book, where they put the pages in order? For one, they’ve not tucked this latest installment of Assassin’s Creed’s meta saga in a book. I also enjoy the unordered delivery, the dawning comprehension of a story about 2096’s desperate people and questionable tech, which I glimpsed first at its middle, then the end, then the front, then other moments in between1. I am also enamored with the idea of the Assassin’s Creed games I’ve previously played, including Black Flag, being repurposed for an information war. The ideas in Resynced’s meta-story, which builds off characters and ideas in Shadows’ chunks of text, are strong. The potential of where they could go with it is exciting. As for the pirate stuff? Looks great, controls pretty well, is fun to play and oh so speedy in terms of how much of a good time you can have with each sit-down. It never gets old to chase a new shanty page across a rooftop, bombard a fort with upgraded mortars or use a diving bell to explore sunken wrecks (hats off to the team at Ubisoft Barcelona that worked on the underwater portions in Resynced; that team is now facing layoffs, such is the misery of modern gaming and oft-troubled Ubisoft). New pirate missions in Resynced involving new ally characters are brief, dramatic and add more to Edward’s story, even if the gameplay perks they provide barely enhance the gameplay. A new denouement for high-class pirate Stede Bonnet is affecting; a new hunt for Blackbeard’s treasure is a welcome extra moment. A new epilogue to hunt down a pirate killer, on the other hand, over-complicates Kenway’s character. The ending credits remain my favorite of any game I’ve ever played. Black Flag provides great source material. The revisit is well-made and a great sign of what could be. It is offered in a different wrapper that hints at an opportunity for more interesting remakes to come, should Ubisoft choose to pursue such treasures—and as we brace to resist or comply with an Abstergo future. 1 The messages that Edward Kenway finds in bottles tell another out-of-order story, one about a man reckoning with the strange memories and voices he’s heard in his head since he was a boy. That tale was also in the 2013 game and develops into one of Black Flag’s most compelling character arcs. In Resynced, it has lost its climax, because the bottle story previously paid off in the halls of the first-person Abstergo Entertainment, which is exclusive to the older game. An altered resolution, written by the 2013 game’s lead writer is fine, doesn’t invalidate the 2013 version, but makes for an inferior final note.
Venezuela earthquake health response enters early recovery phase as focus shifts to restoring essential health services
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Florida business establishment remains quiet on property tax amendment
Less than four months before Floridians vote on a proposal to phase out property taxes for homeowners, there’s no organized campaign seeking to move the measure past the 60% vote required for passage....
AB Science cuts three trials in pipeline reset
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When regulation is good for business
By now, I think I have established both my view that I am a fan of ESG investing and the benefits of regulating what is and isn’t a sustainable investment, and my view that in Europe, ESG regulation has gone too far and become too costly. It almost feels like the old Aristotelian maxim of doing things in moderation that leads to the best outcomes is valid in regulatory efforts as well. To give you an example, let’s look at a study by the National Bank of Belgium on the impact of the EU’s Sustainable Finance Disclosure Regulation (SFDR) on fund flows of conventional and ESG funds. The SFDR was announced on 27 November 2019 and came into effect on 10 March 2021. It was implemented in several stages and split funds marketed in the EU into three broad categories: (i) Art. 6 funds that are basically conventional funds without any specific ESG integration, (ii) Art. 8 funds that ‘promote environmental or social characteristics’, which must provide additional reporting how they do that, and (iii) Art. 9 funds that are impact funds. The gaps between the announcement and the phased implementation give us an idea of how fund flows were affected by the regulation. It is clearly visible in the figure below that once the new regulation was announced and when it was initially implemented, fund flows in Art. 8 and Art. 9 funds increased significantly. Conventional Art. 6 funds also saw more inflows, but the increase was not statistically significant. I should add that the data below is pure fund flow, cleaned of performance effects and of any reclassified funds that moved from one classification to another. Note also that once the initial rush in ESG funds was over, additional, stricter regulatory requirements didn’t create that many new flows. This implies that with additional regulation, the funds incurred higher costs to comply but didn’t benefit in terms of new inflows and higher assets under management. Fund flows as the SFDR regulation was implemented in the EU Source: Emiris et al. (2026) When examining the drivers of these flows, the authors of the study found that institutional investors were more likely to switch to ESG funds and particularly so in countries where concerns about sustainability are culturally more accepted. In a society where buy-in into environmental and social risks is higher, private investors were shifting more of their assets into ESG funds as the regulation made it clear which funds are really green and which ones are not. And institutional investors in these countries did so as well, given the societal pressures and reputational risks of sticking with conventional funds. Meanwhile, fund managers reacted to the changing regulatory environment as well. Many funds that were mildly green before the regulation was announced became greener and more sustainable as the regulation was introduced to attract new assets and new investors. Cleverly, and unsurprisingly, these ESG funds also charge on average higher fees, which means that not only did fund managers gather fresh assets, but their profitability increased as well.
'Soulframe': Sign Up by July 13 for "Unlimited Play Until Official Launch"
©Digital ExtremesTo celebrate TennoCon 2026, Digital Extremes is granting permanent access to the pre-alpha 'Preludes' phase of its new fantasy action RPG, 'Soulframe.Previous...
Trump says the Iran ceasefire is ‘OVER.’ What now?
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UND health professions addition in design phase as leaders envision the future of healthcare education
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Your menstrual cycle may affect how well vaccines work
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CVC Capital Partners to Buy Ingredients Business Irca From Advent
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Morris rides into orange and purple western town with unfinished business
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AB Science reports completion of the step 3 of phase 1, evaluating the combination of AB8939 with venetoclax for the treatment of refractory or relapsed AML
PRESS RELEASE AB SCIENCE REPORTS COMPLETION OF THE STEP 3 OF PHASE 1, EVALUATING THE COMBINATION OF AB8939 WITH VENETOCLAX FOR THE TREATMENT OF REFRACTORY OR RELAPSED ACUTE MYELOID LEUKEMIA THE COMBINATION OF AB8939 WITH VENETOCLAX GENERATED A 67% OVERALL RESPONSE RATE (ORR) AND A 100% DISEASE CONTROL RATE (DCR), WITH NO DOSE-LIMITING TOXICITIES (DLT) OBSERVED, IN A POOR-PROGNOSIS POPULATION WITH ADVERSE GENETICS TREATED IN THE SECOND - TO FOURTH-LINE RELAPSED OR REFRACTORY SETTING Paris, June 2
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Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
A new vision for quantum computing takes a big step forward, with new grant
A $4 million National Science Foundation grant will propel the next phase of a Yale-led project to build a quantum computer with an innovative new design.
Ohio State–led team secures NSF award to advance to next phase of the National Quantum Virtual Laboratory program
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State advances over four hundred projects in bid for Rural Health Transformation Program funding
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Federal health agencies unveil plan to speed up phase 1 clinical trials by 6 to 12 months
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Business Monday: Kona Brewing’s historic Kona Pub creating beer garden entrance to make waiting enjoyable
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Evonik to Cut 3,200 Jobs, Discontinue Polyester Unit as Part of Restructuring Plan
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Austin Transit Partnership reviews light rail design as business stresses about relocation
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iPhone Air With Dual Lens Camera Coming in Spring 2027
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