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UFC 334 announced, heavyweight title fight headlines massive NYC card

UFC 334 full card announced during 331 broadcast

Sep 19 • 11:36 PM EDT • Sports • sports.yahoo.com

Official Galaxy Tab S12+ Keyboards Leak Online Ahead of Expected October Launch

Leaked renders from a retail listing reveal Samsung's official Book Cover Keyboard Slim and Pro Keyboard for the upcoming Galaxy Tab S12+.

Sep 19 • 12:08 PM EDT • Technology • androidheadlines.com

Beyond the Headlines: Don Davis discusses health care, rural needs and District 1 race

U.S. Rep. Don Davis sat down with News 12 for a wide-ranging Beyond the Headlines interview about issues affecting North Carolina's 1st Congressional District a

Sep 19 • 12:00 PM EDT • Health • wcti12.com

48 hours after $15M lawsuit text drop, Carrot Top attempts to take his life; Vegas headliner hospitalized...

His long-running headlining residency at the Luxor was abruptly canceled following the emergency.

Sep 19 • 8:12 AM EDT • Entertainment • kansascity.com

Sen. Rick Scott headlines New Hampshire GOP dinner

U.S. Sen. Rick Scott (R-Florida) visited the Granite State on Friday, headlining the New Hampshire GOP Amos Tuck Dinner.

Sep 18 • 9:21 PM EDT • Politics • wmur.com

Frankie Muniz Talks 'Hitting Rock Bottom' and More Top Us Stories

Get a rundown of Us‘ top stories making headlines in celebrity news, sports and entertainment on September 18, 2026.

Sep 18 • 7:06 PM EDT • Entertainment • fresnobee.com

Walter Anderson Museum of Art hosting Science Saturday

Art and science come together this weekend at the Walter Anderson Museum of Art for Science Saturday, a hands-on celebration of STEAM in conjunction with the Mississippi Science Festival. Joining us is Director of Arts and Environmental Education Sandra Bilbo with more. Categories: Community Headlines, Local News Tags: Walter Anderson museum of Art

Sep 18 • 5:00 PM EDT • Science • wxxv25.com

Fox News Entertainment newsletter: King Charles draws ‘line in the sand'; Harry and Meghan's school-run issues

The Fox News Entertainment Newsletter brings you the latest Hollywood headlines, celebrity interviews and stories from Los Angeles and beyond.

Sep 18 • 3:07 PM EDT • Entertainment • foxnews.com

Analytics and Data Science News for the Week of September 18; Updates from Alteryx, Databricks, Golden Analytics & More

Solutions Review Executive Editor Tim King curated this list of notable analytics and data science news for the week of September 18, 2026. Keeping tabs on all the most relevant analytics and data science news can be a time-consuming task. As a result, our editorial team aims to provide a summary of the top headlines […]

Sep 18 • 2:22 PM EDT • Science • solutionsreview.com

Phantoms to headline entertainment lineup at Bentley Scottsdale Polo Championships

The 15th annual Bentley Scottsdale Polo Championships will feature electronic music duo Phantoms as part of the event’s entertainment lineup this fall.

Sep 18 • 1:00 PM EDT • Entertainment • arizonadigitalfreepress.com

The Prestige Eatery and Entertainment brings Vegas to the stage

Singer Lady Yvonne will headline spectacular show paying tribute to some of music's greatest artists.

Sep 18 • 9:11 AM EDT • Entertainment • fox2detroit.com

Oregon Ducks Football News

Oregon Ducks headlines from around the country

Sep 18 • 8:59 AM EDT • Sports • sports.yahoo.com

Letter to the editor: Good science requires patience

It was no surprise to see the Aug. 23 headline about school vaccine rates falling and rising cases of measles in Pennsylvania, and then to see the Health...

Sep 18 • 6:00 AM EDT • Science • post-gazette.com

Bills' Ed Oliver Headlines Week 2 Inactives Against Lions

Buffalo Bills star defensive tackle Ed Oliver is a surprise scratch against the Detroit Lions.

Sep 17 • 8:12 PM EDT • Sports • sports.yahoo.com

WWLTV

WWL-TV is New Orleans’ source for breaking news, weather, and unforgettable local stories. From live hurricane coverage to major investigations, recipes and local culture, our award-winning team brings you the most trusted journalism in Louisiana — now streaming FREE on WWL+ 24/7. 📲 Subscribe for exclusive digital specials, daily headlines, live press conferences, festival coverage, Saints updates and must-watch moments from across Southeast Louisiana. 🎥 Watch now on WWL+ or visit WWLTV.com for more. WWLTV.com: https://www.wwltv.com/ Local. Trusted. Relentless. Welcome to WWL-TV.

Sep 17 • 6:10 PM EDT • Entertainment • youtube.com

As Senate prepares to score on college sports regulation, House goes home until election

College sports are back in full swing and unregulated NIL deals are still making headlines.

Sep 17 • 4:27 PM EDT • Sports • wctv.tv

2026 College Football Watch Guide

An unfriendly reunion in Oxford headlines week 3. Will it be a happy homecoming for Kiffin?

Sep 17 • 3:37 PM EDT • Sports • sports.yahoo.com

Larkin ‘Ready to be Bottom of the Totem Pole Again’

After an offseason dominated by headlines with his name in them, former Red Wings captain Dylan Larkin seemingly would rather […]

Sep 17 • 2:34 PM EDT • Sports • sports.yahoo.com

Burna Boy to headline NFL halftime show in Paris

Burna Boy for 'Global Citizen Live.' (ABC)Burna Boy will take the stage at the NFL's debut in France.The Nigerian Afro-fusion singer was named as the headline performer for the NFL's Paris Game on Oct. 25 at Stade de France, in an exclusive announcement on Good Morning America Thursday morning.The NFL Paris Game will be the first NFL game played in France, and one of a record nine international games played this season.The Paris Game, played between the Pittsburgh Steelers and New Orleans Saints, is one of seven international games that will feature a halftime show this season.Burna Boy, a native of Nigeria and the artist behind songs such as "Last Last" and "Love," shared a statement on the event in a release from the NFL regarding the show."The NFL is bringing something to France that has never happened here before, and I get to stand in the middle of it representing African music and I intend to give the people a show they will not forget," he stated.Tim Tubito, senior director of global game presentation, music and entertainment at the NFL, said in a statement, "Paris is one of the great cultural capitals of the world, and African music sits right at the heart of what the city listens to."The Jonas Brothers, Pedro Sampaio and Ricky Martin, Ayra Starr, Cage The Elephant and The Warning have already been announced as international game performers at NFL games this season, according to the release.Rio de Janeiro and Paris will both see NFL games for the first time this year, while London, Madrid, Munich and Mexico City will return as hosts this season. Melbourne also hosted their first NFL game earlier this season.The Paris Game will air Sunday, Oct. 25, at 9:30 a.m. ET on the NFL Network.Copyright © 2026, ABC Audio. All rights reserved.

Sep 17 • 1:22 PM EDT • Entertainment • willmarradio.com

Tyler Dibling Earns MOTM For Everton, But What's Next?

Everton winger Tyler Dibling grabbed the headlines with an impressive performance against Wolves in the Carabao Cup.

Sep 17 • 12:28 PM EDT • Sports • sports.yahoo.com

Burna Boy to headline NFL halftime show in Paris

Burna Boy for 'Global Citizen Live.' (ABC)

Sep 17 • 11:30 AM EDT • Entertainment • kmaland.com

The latest in entertainment headlines with Side Dish Co-Host "Headkrack"

Law Roach squashes rumors of tension between him and an actress, and Sheryl Lee Ralph is apologizing after saying her series was the only "real" comedy nominated at the Emmys.

Sep 17 • 10:50 AM EDT • Entertainment • fox5atlanta.com

Giants add needed heft before their first real road test

The Giants did not make Wednesday’s roster move to generate a headline. They signed defensive tackle Josh Tupou from the […]

Sep 17 • 9:09 AM EDT • Sports • sports.yahoo.com

Burna Boy to headline halftime at the NFL's first regular-season game in Paris

Burna Boy is set to headline the halftime show at the NFL's first regular-season game in Paris. The Grammy-winning Nigerian star will perform on October 25 when the Pittsburgh Steelers

Sep 17 • 8:50 AM EDT • Entertainment • yakimaherald.com

Rangers’ Top Prospects Headline Strong Arizona Fall League

The Texas Rangers will send three of their top 30 prospects to the Arizona Fall League.

Sep 17 • 8:00 AM EDT • Sports • sports.yahoo.com

The Strange New Politics of AI. Plus. . .

It’s Thursday, September 17. This is The Front Page, your daily window into the world of The Free Press—and our take on the world at large. Today: Douglas Murray asks, why do we allow terrorists to die of old age? The American nonprofits backing Hamas. A conversation with Dara Horn and Coleman Hughes. And much more. But first: inside the unlikely coalition warning that AI may kill us all. Last week, an AI researcher named Jacob Coxon made headlines around the world after saying that he had resigned from Anthropic because he believes AI might cause human extinction—and his co-workers do, too. Unlike the rest of us, potentially, the story just won’t die. The Pro-Human Assembly, a conference held Tuesday in Washington, D.C., about the existential dangers of artificial intelligence, couldn’t have come at a better time—or with a more eclectic coalition. The Archbishop of San Francisco was there. So was Steve Bannon, screaming about the Chinese. Bernie Sanders did a quasi-dramatic reading of messages posted to an online forum by rogue AI agents. Ashley Judd paraphrased a graphic Andrea Dworkin quote for reasons that remain a mystery to me still. It was odd. People in the AI industry have talked openly about the possibility of this technology causing human extinction for years, but it hits differently in the wake of the Hugging Face incident. If you don’t know what that is, all the more reason to read my dispatch today. As the doomers see it, the best-case scenario is a future in which humans are basically kept as pets: well cared for, but with zero autonomy. The worst-case scenario, obviously, is the everyone dies thing. What should be done? I heard lots of ideas but no easy answers. There are currently zero federal regulations on AI, which is sort of strange even to think about. After all, we regulate microwaves, and the people running the microwave industry have never once refused to rule out the possibility that their products will end all human life on Earth. What I saw in D.C. left me even more convinced that you would be hard-pressed to find anyone who believes nothing should be done. You know, except for President Trump. — River Page River Page • Tech and Business [ The AI Doomers Have a Plan to Save Us. I Went to Find Out What It Is. ](https://www.thefp.com/p/the-ai-doomers-have-plan-save-bernie-sanders-bannon) Read story How Robert Kraft Made Macklemore a Martyr—and How to Better Fight Antisemitism On Monday, New England Patriots owner Robert Kraft and a group of other NFL owners banned Macklemore from performing at their stadiums after the rapper delivered a “Free Palestine” speech while opening for Ed Sheeran. Kraft cited the rapper’s “broader history of antisemitic rhetoric and imagery.” Once multiple venues refused to host shows with Macklemore on the lineup, the tour’s promoter officially dropped him. Today, Josh Kaplan says that the move was counterproductive, arguing that though well-intentioned, Kraft’s decision turned an irrelevant footnote into a martyr. “You cannot cancel people into liking you,” Josh writes. Read his column on what a better response to Macklemore would have looked like. Read [ Robert Kraft Made Macklemore a Martyr ](https://www.thefp.com/p/robert-kraft-made-macklemore-martyr-antisemitism-palestine) This raises the question: What actually works against antisemitism? On the latest episode of Conversations with Coleman, recorded in front of a live audience in New York, Dara Horn joins Coleman Hughes to talk about her new book The Final Solution to the Jewish Question. She argues that antisemitism is a script that has repeated itself across countries and ideologies, and that most people don’t understand that well enough to fight it. Don’t miss their conversation. Watch [ The Lie at the Center of Antisemitism, with Dara Horn ](https://www.thefp.com/p/the-lie-at-the-center-of-antisemitism-coleman-hughes-dana-horn) Listen now Douglas Murray • U.S. Politics [ Douglas Murray: The 9/11 Failure That Still Haunts America ](https://www.thefp.com/p/douglas-murray-911-failure-justice-terrorist-guantanamo-bay) Twenty-five years after the September 11 attacks, the men who planned them have still not faced trial. Khalid Sheikh Mohammed and most of the accused have been locked up in Guantanamo Bay since 2002. Judges have retired, and plea deals have collapsed. Today, Douglas Murray examines how this happened and argues that a justice system that allows terrorists to die of old age in an interminable pretrial process is one that has failed. Read his latest column on what that failure says about our unpreparedness for the era we are now living in. Read story The Editors • U.S. Politics [ When Nonprofits Support Terrorists ](https://www.thefp.com/p/when-nonprofits-support-terrorists) A newly declassified CIA brief from 1998 found that Osama bin Laden used nonprofit shell organizations—including U.S.-based Islamic groups—to fund his terror plots. Today, a similar story is unfolding as multiple organizations on American soil present themselves as nonprofits, taking advantage of tax-exempt status while seeking to advance the ideological mission of terrorist groups like Hamas. Read our editorial on the latest evidence of this dangerous trend—and why there’s no excuse for making the same mistake the CIA revealed 28 years ago. Read story Simon Sebag Montefiore and Bari Weiss Live in New York For decades, the Middle East has shaped American foreign policy and loomed large in the public consciousness. Few understand its influence on our politics better than Simon Sebag Montefiore, who argues that America’s quagmires in the Middle East stem from a deep misunderstanding of the region—on both the left and the right. Join him October 1 as he sits down with Bari Weiss live in New York City to kick off his U.S. book tour for The Cauldron: The Making of the Modern Middle East. Get Tickets Now MORE FROM THE FREE PRESS [ Sydney Sweeney’s Naked Truth ](https://www.thefp.com/p/sydney-sweeneys-naked-truth-caitlin-flanagan) Caitlin Flanagan Read story [ I Thought Ukraine Was Losing. Then I Was Almost Hit by a Russian Drone. ](https://www.thefp.com/p/elliot-ackerman-ukraine-drone-gas-station-train) Elliot Ackerman Read story [ The Dangerous Ideology Behind the AI Warnings ](https://www.thefp.com/p/dangerous-ideology-effective-altruism-artificial-intelligence) Shyam Sankar Read story [ Amanda Knox: Patrick Clancy Can’t Win ](https://www.thefp.com/p/amanda-knox-patrick-clancy-grief-internet-crime) Amanda Knox Read story THE NEWS The Federal Reserve raised interest rates by a quarter point, its first hike since 2023, signaling that another increase could follow as the central bank tries to bring inflation under control. President Donald Trump fired back by demanding that rates be cut sharply, though he stopped short of criticizing Fed Chair Kevin Warsh by name. The Houthis fired drones and missiles at Saudi Arabia on Wednesday, including a major oil port on the Red Sea, and Saudi jets struck back with air strikes across Yemen in an escalating front of the Middle East war. (For more on the Houthis, read Zineb Riboua’s column from earlier this week.) A sweeping Russia and Iran sanctions bill passed the House in a 262–159 vote and is now heading to Trump for his signature. Named after the late senator Lindsey Graham, the legislation would hit countries that purchase large volumes of Russian oil and gas with tariffs of up to 100 percent, and is aimed at cutting off revenue that funds Russia’s war in Ukraine. European Commission president Ursula von der Leyen proposed making Canada the European Union’s first-ever “associate member,” drawing a standing ovation from European lawmakers. The proposal, framed as a response to a world grown more hostile, faces an uncertain path as EU member states would have to approve it, and one diplomat said that “nobody really ​knows what it means.” The House voted unanimously to send billionaire Leon Black a criminal contempt referral after he defied a congressional subpoena to testify and hand over documents related to his connections to Jeffrey Epstein. Black chose to fight the subpoena in court rather than comply. Charlie Kirk’s family filed a wrongful death notice Wednesday against Utah Valley University, alleging that a series of security failures left him exposed to a rooftop sniper. The notice is a required legal step before the family can sue. Merriam-Webster added 1,400 words and definitions to its dictionary, including looksmaxxing, vibe coding, and cuffing season. The publisher said the new entries offer “a window into the world today.” The Free Press earns a commission from any purchases made through all book links in this article.

Sep 17 • 6:03 AM EDT • Politics • thefp.com

John Calipari headlines Memphis Sports Hall of Fame

Sep 16 • 11:27 PM EDT • Sports • sports.yahoo.com

AMS Science Preview: High-Res Global Forecasting, Tornado Emergencies

Recent research in AMS journals spotlights tornado emergencies, kilometer-scale global weather forecasting, a new normal for polar sea ice, links between Tibetan snow cover and intense tropical…

Sep 16 • 4:53 PM EDT • Science • headlines.ametsoc.org

House Primary Results 2026: A Closer Look at the Numbers Behind Incumbent Defeats

The biggest headlines from this year’s primary season seemed to trumpet races in which centrist incumbents from both major parties were ousted in favor of nominees with more extreme views. President Donald Trump publicly targeted Republican lawmakers he thinks have not been sufficiently loyal to him ...

Sep 16 • 1:46 PM EDT • Politics • usnews.com

Colts news: Keenan Allen formally charged after preseason arrest

Indianapolis Colts wide receiver Keenan Allen was in the headlines recently after a run-in with the law. Allen was arrested for drunk driving after failing a sobriety test in the city. Now, the veteran wide receiver has been formally charged with two misdemeanor counts, per Fox59. “Court records show Allen is formally charged with operating a […] The post Colts news: Keenan Allen formally charged after preseason arrest appeared first on ClutchPoints.

Sep 16 • 11:39 AM EDT • Sports • sports.yahoo.com

Specialties Honor Roll: Health Law

Health care is big business, and it’s constantly changing. New medicines and medical devices enter the market, regulations change and artificial intelligence is quickly changing the health care landscape. Ads for prescription drugs and health products are everywhere, while debates over access to care continue to make headlines. Behind all of it are legal issues. […]

Sep 16 • 11:37 AM EDT • Health • nationaljurist.com

The Bonnie Banks gives the latest in entertainment headlines

Oprah is eyeing Las Vegas for her next big project, and American Idol is heading to Metro Atlanta.

Sep 16 • 10:54 AM EDT • Entertainment • fox5atlanta.com

Why awarding Monaco a sprint race completely detracts from exciting 2027 F1 calendar

Comment: Two popular venues returning and more sprint races in the schedule should be the main headline; instead, Formula 1 has bafflingly put an extra race at a circuit you can’t overtake at

Sep 16 • 10:35 AM EDT • Sports • sports.yahoo.com

Toward A Proper Definition Of “Overrated”

The YouTube title of this week’s All Ball episode is “Jalen Hurts Is OVERRATED.” This sort of headline is known as “clickbait,” or “ragebait.” But what if I told you that Arif Hasan and I spent time in this episode striving toward a more nuanced version of “overrated,” a word which itself has become overrated?…

Sep 16 • 10:22 AM EDT • Technology • defector.com

Electrical Manufacturers See Stronger Business Conditions

Survey respondents cite stronger activity despite inflation and policy uncertainty

Sep 16 • 7:00 AM EDT • Business • inside.lighting

Fair play: Elche react after Villar and Mbappé clash 📸

The tense confrontation between Gonzalo Villar and Kylian Mbappé after Real Madrid's dramatic 2-3 win over Elche is still making headlines. Far from calming things down, the Elche club reacted on soc...

Sep 16 • 5:50 AM EDT • Sports • sports.yahoo.com

Fair play: Elche react after Villar and Mbappé clash 📸

The tense confrontation between Gonzalo Villar and Kylian Mbappé after Real Madrid’s dramatic 2-3 win over Elche is still making headlines. Far from calming things down, the Elche club reacted on s...

Sep 16 • 5:20 AM EDT • Sports • sports.yahoo.com

Whitney Houston production headlines Norwegian Aura entertainment lineup

Norwegian Cruise Line has unveiled the entertainment lineup for its new ship, Norwegian Aura, including a headline production called Whitney: A Celebration of Whitney Houston. Developed with...

Sep 16 • 3:26 AM EDT • Entertainment • cruiseandferry.net

Can Flutter Entertainment (FLUT) Still Be Worth More On Sales?

Flutter Entertainment has seen its stock slide sharply over the past year, and that slump now puts a spotlight on a simple question. Is the current share price in any way justified by the sales the business is generating? Over the past 12 months, Flutter Entertainment shares have fallen 64.3%. This puts recent market confidence in the business under scrutiny when you compare it with what the company is actually selling. Fresh headlines around potential regulatory clarity for sports...

Sep 15 • 7:25 PM EDT • Entertainment • simplywall.st

Dave & Buster's Entertainment (PLAY) Stock Sinks Deeper Into Losses As Margins Shrink

Dave & Buster’s Entertainment just saw its stock hit the floor, dropping 19% to US$6.86. Yet the real story is not a one day slide; the headline is a sharp earnings hit. Q2 delivered a net loss of US$12.5 million on US$544.1 million of revenue, pulling trailing twelve month earnings deeper into the red and keeping interest coverage under pressure. For traders, this is a clean miss. For anyone thinking beyond this quarter, the question is how long the balance sheet can carry an unprofitable...

Sep 15 • 6:23 PM EDT • Entertainment • simplywall.st

Biltmore Championship Odds, Picks And Best Bets For Asheville

Ben James, Jacob Bridgeman and Rasmus Højgaard headline the best bets as the PGA Tour opens its FedExCup Fall at a brand-new Asheville venue this week.

Sep 15 • 6:00 PM EDT • Sports • sports.yahoo.com

Sports luminaries Brandi Chastain, Candace Parker to speak at UC Davis symposium

Two of the most celebrated and influential athletes in women’s sports, Olympic gold medalists Brandi Chastain and Candace Parker, will headline an Oct. 4 symposium at the Mondavi Center for the Performing Arts on leadership, resilience and the future of women’s professional sports. Tickets are on sale now.

Sep 15 • 5:26 PM EDT • Sports • giving.ucdavis.edu

Ed Sheeran addresses Macklemore removal from tour after Palestine comments

NEW YORK — Ed Sheeran is speaking out after Macklemore was pulled as the supporting act on his tour following comments the rapper made about Palestine. According to the headliner,

Sep 15 • 4:23 PM EDT • Entertainment • recorderonline.com

Whitney Houston show to headline NCL's Norwegian Aura

New, original Whitney Houston show will headline entertainment aboard Norwegian Cruise Line's 2027 ship, Norwegian Aura

Sep 15 • 1:29 PM EDT • Entertainment • seatrade-cruise.com

Jay Park, K-pop star, ready for homecoming Seattle show with LNGSHOT

Edmonds-born K-pop idol Jay Park marks his return to Washington with a homecoming headline show at Seattle’s WAMU Theater this month.

Sep 15 • 1:00 PM EDT • Entertainment • yakimaherald.com

Mastercard’s Dreamonomics Report Finds Small Business Owners Are Redefining Growth for a More Demanding Economy: 68% Prioritize Stability Over Speed, 89% Want More Digital Tools and 71% Say Cyber Protection Is a Priority

To support the needs of small businesses, Mastercard Collection for Business launches today bringing together business-focused benefits, protections and experiences Small businesses are looking ahead with ambition — but they are also preparing for the pressure that comes when opportunity arrives. Mastercard today introduced Dreamonomics, a new global view of the forces reshaping small and medium-sized enterprises (SMEs) perceptions and approach to growth. The research shows that SMEs are redefining growth as controlled momentum: 68% prioritize stability and predictability over fast growth, 54% actively avoid unnecessary financial risk and 61% are focused on deepening customer relationships rather than reaching as many customers as possible. Studio Mouvoir Headline Findings from the new Dreamonomics Report Stability is overtaking speed: 68% of SMEs now prioritize stability and predictability over fast growth, while 54% say they actively avoid unnecessary financial risk. Customer depth

Sep 15 • 9:14 AM EDT • Business • investor.mastercard.com

Soccer, high school football, UConn volleyball headline live sports on WWAX, WFSB+ this week

Here are the games scheduled to be broadcast and streamed on WWAX and WFSB+ the week of Sept. 14, 2026.

Sep 15 • 6:54 AM EDT • Sports • wfsb.com

RFK Jr. to headline Children’s Health Defense conference in D.C.

Health and Human Services (HHS) Secretary Robert F. Kennedy Jr. is scheduled to give a keynote address this week at a conference for Children’s Health Defense (CHD), the anti-vaccine advocacy organ…

Sep 14 • 3:48 PM EDT • Health • thehill.com

Please Stop Conflating Sports Betting Handle With Spending On Entertainment

Editor’s note: The Cashout for paid subscribers will publish on Tuesday. Every September there’s a huge uptick in how much people bet on sports with the start of football season. Which means it’s time to get ahead of a ridiculous narrative before it picks up steam on social media or in mainstream media. Subscribe Every few months I see some version of this: [ Charlie Bilello@charliebilello Americans bet over $165 billion on sports last year, which is more than they spent on movies, books, concerts and sports tickets - combined. 1:00 PM · Jun 28, 2026 · 4.1M Views 258 Replies · 674 Reposts · 4.23K Likes ](https://x.com/charliebilello/status/2071217050328895935?s=20) Fortune published this in July. The headline and start of the story tell the same narrative (emphasis added): Gambling becomes America’s favorite pastime as Americans spend more on sports bets than movies, arts, museums, and music combined: The North American box office totaled $8.87 billion in 2025, which is still 22% below pre-pandemic levels. Recorded music revenue hit a record $11.5 billion. Live music like concerts and festivals brought in $18.51 billion. Meanwhile, book publishers tracked by the Association of American Publishers reported $14.6 billion for the year. And the U.S. museum industry generated an estimated $16.4 billion. Add it up and the total comes to roughly $70 billion, which is less than half what Americans wagered on sports. The story, to its credit, goes on to tell us why sports betting is entirely different, although people who only read headlines will miss that nuance. (The tweet above definitely skips over the nuance.) I will mostly be preaching to the choir here, but it’s worth saying out loud: Wagering money on sports is not the same thing as spending on entertainment from a financial perspective. When you spend money on a movie or concert ticket, that money is gone. You exchanged money for an experience. It’s a good trade! I get to have fun for “x” dollars. (Unless the movie sucks, I guess.) When you bet money on sports, the money is not necessarily gone every time you wager it. It could be gone, but sometimes it’s not and you actually get more money back! That’s not “spending” money or something you should try to compare directly to entertainment spend. A far better comp would be how much people lose at sports betting. That number was more like $17 billion in the US last year, at least for state-regulated sportsbooks. Why are we trying to equate handle and entertainment spending? I dunno. It makes for splashy headlines, I guess. Now, people should be betting for entertainment, and not because they expect to win in the long term; no doubt about it. Anyway, here’s hoping I don’t see people saying Americans “spent” hundreds of millions of dollars on sports betting this fall. Mindway AI and DraftKings Expand Responsible Gaming Drive with Launch of Gamalyze American Football In time for the NFL kickoff, Mindway AI has expanded its partnership with DraftKings to launch Gamalyze American Football the second title in the neuroscience-based Gamalyze Sports collection. Following the success of Gamalyze Football (soccer) during the FIFA World Cup, this gridiron-themed update replaces static questionnaires with immersive, stadium-inspired gameplay. Backed by 10+ years of Aarhus University research, Gamalyze evaluates real-time decision-making to deliver instant, unbiased player risk assessments. Integrated into DraftKings’ platform and nationwide activations, it engages fans when excitement peaks. Ready to upgrade your player protection? Contact Mindway AI to try Gamalyze Sports today. Gambling news roundup 🚨The important stuff 1st NFL Sunday of Season ‘Champagne-Popping Day for Bettors’ (Covers): “The first NFL Sunday of the season was a champagne-popping day for bettors, while the book was left cleaning up the corks,” Caesars’ head of football Joey Feazel said prior to the Sunday night game. “Caesars Sportsbook reported that Detroit’s Jahmyr Gibbs, Baltimore’s Derrick Henry, Indianapolis’ Jonathan Taylor, and Atlanta’s Bijan Robinson were among the top five most-bet players to reach the end zone, and all of them cashed tickets.” [ Ben Fawkes@BFawkes22 A @CaesarsSports oddsmaker on how Week 1 has gone so far: “The first NFL Sunday of the season was a champagne-popping day for bettors, while the book was left cleaning up the corks.” ➡️8 of 10 most popular anytime TD scorers cashed 1:31 AM · Sep 14, 2026 · 276K Views 16 Replies · 16 Reposts · 615 Likes ](https://x.com/BFawkes22/status/2099310001927995849?s=20) 🔍 Are we already getting a “customer-friendly results” narrative in Week 1? NFL Commissioner Roger Goodell spoke with CNBC about the prediction markets industry: “We think that there needs to be stronger regulations into the predictive markets,” Goodell said. “We want to see that to protect the integrity of our game. We want to make sure we’re protecting the consumers that are on those platforms for the NFL. So, we’re continuing to have conversations with them and talk to them about the things that we think they need to do to strengthen that so that they could be potential partners at some point in the future.” More on the NFL + PMs: [ Straight to the Point Quid Pro Quo The NFL has asked Kalshi and other prediction markets to remove certain easy to manipulate markets. Does a potential partnership hang in the balance… Read more 6 hours ago · 19 likes · Steve Ruddock ](https://straighttothepoint.substack.com/p/quid-pro-quo?utm_source=substack&utm_campaign=post_embed&utm_medium=web&embedding_publication_id=1472492) Kalshi was on my podcast?: Kalshi was on my podcast [ The Event Horizon Episode 32: Talking Prediction Market Enforcement With Kalshi’s Robert DeNault Kalshi? On my podcast? Yep… Listen now 5 hours ago · 6 likes · 1 comment · Dustin Gouker ](https://nexteventhorizon.substack.com/p/episode-32-talking-prediction-market-enforcement-kalshi?utm_source=substack&utm_campaign=post_embed&utm_medium=web&embedding_publication_id=1472492) DraftKings Enhances Responsible Engagement Efforts With New Customer Initiatives, Tools and Education (press release): DraftKings Inc. today announced a series of new initiatives designed to promote responsible engagement and increase awareness and use of the tools and resources to help customers make informed decisions and engage responsibly. The efforts include a new digital advertising campaign featuring Kevin Hart and Nick Jonas that promotes responsible engagement, a PGA TOUR sweepstakes that promotes customer engagement with responsible engagement features, the launch of Gamalyze American Football in collaboration with Mindway AI, and new custom cool-off options that give customers enhanced flexibility when choosing a cool-off period. The initiatives build on DraftKings’ commitment to making responsible engagement an integral part of the customer experience and providing players with accessible tools and resources that help them make informed choices about their gaming experience. “At DraftKings, responsible engagement is embedded in how we operate and is essential to building trust with our customers and our long-term sustainability,” said Lori Kalani, Chief Responsible Gaming Officer at DraftKings. “We’ve continued to invest in tools and resources that give customers enhanced access to information about their play and more choices for managing how they engage. From My Budget Builder and My Stat Sheet to player-set limits and new custom cool-offs, we’re continuing to evolve our approach while promoting awareness and use of the tools and resources available to help customers play responsibly.” … DraftKings is launching a new digital advertising campaign featuring Kevin Hart and Nick Jonas that continues the pair’s road trip and promotes responsible engagement and awareness of the tools and resources available to help customers make informed choices about their gaming experience and engage responsibly. The campaign was initially launched on Sep. 10th and will reach customers through digital channels, bringing responsible engagement messaging to fans in an engaging way. bet365 Launches “The Matchup,” a New Weekly Video Podcast Hosted by Super Bowl Champions Chris Harris Jr. and Emmanuel Sanders (press release): "bet365, a global leader in online sports betting and gaming, today announced the launch of “The Matchup,” a new weekly video podcast hosted by former Super Bowl Champions Chris Harris Jr. and Emmanuel Sanders. Featuring current and former NFL players, the original series marks a significant, intentional investment in football as bet365 works to become a go-to destination for U.S. bettors throughout the season. “The Matchup” premieres September 10, with new episodes released weekly in both video and audio formats. Full episodes will be available on YouTube, Apple Podcasts, Spotify and wherever podcasts are available, with clips and additional content rolling out across YouTube, X, Instagram, Facebook, Threads, and TikTok. The show is being produced by Last Row Digital Media. Each week, Harris and Sanders will be joined by guests from across the game to break down the biggest NFL matchups, unpack the latest league news and share perspectives that go beyond the box score. By bringing together two former players with distinct perspectives and firsthand experience, “The Matchup” will give audiences timely context and a deeper understanding of the teams, players and storylines shaping the week ahead. “Every great football conversation starts with a matchup—who has the edge, what everyone is overlooking and what could change the game,” said Chris Harris Jr. “Emmanuel and I have experienced the game from different perspectives, and we want the audience to feel like they are part of the conversation and leave every episode knowing more about the week ahead.” Today’s iGaming companies face new litigation threats as expansive consumer protection statutes spark lawsuits with sky’s-the-limit aspirations, sometimes backed by private funders. Clients of Ifrah Law have a staunch defender in Robert Ward – an agile litigator and case tactician who responds to the changing state of play with creative legal defenses and efficient case-closing strategies. Robert draws on federal clerkship experience and appellate defense work to advise iGaming clients on litigation exposure, white-collar risk, and regulatory defense across multiple jurisdictions. Read More: Robert Ward on Helping iGaming Clients Outmaneuver Lawsuit-Obsessed Adversaries 🔮 Prediction markets Update on legal action in Connecticut: [ Daniel Wallach@WALLACHLEGAL Connecticut says gaming service license holders which received subpoenas over sports prediction markets “are not under investigation” by the @CTDCP but may possess information that could assist the state “in evaluating the conduct of prediction market platforms.” 2:31 PM · Sep 13, 2026 · 844 Views 5 Likes ](https://x.com/WALLACHLEGAL/status/2099143914271670576?s=20) American Gaming Association Opposes CFTC Bid to Block New York Prediction-Market Enforcement (DeFi Rate): “The brief points to the Ninth Circuit’s Aug. 28 decision in KalshiEX LLC v. Assad, which the AGA says supports New York’s authority to regulate sports contracts as gambling. It also cites Kalshi advertising, product comparisons and reporting on Kalshi’s sports volume to argue that the economic product resembles a sportsbook wager more than a conventional financial hedge.” [ Daniel Wallach@WALLACHLEGAL AGA intervenes in CFTC v. NY case to oppose CFTC request for preliminary injunction, says the CFTC’s arguments “obfuscate a simple truth: prediction markets offer sports betting.” Highlights CA9 decision, @DustinGouker (6x), and $1.32 billion in OSB taxes for NY (0 from PMs). Daniel Wallach @WALLACHLEGAL High stakes hearing on Monday in CFTC v. New York State. If SDNY judge Lorna Schofield denies the CFTC’s motion for preliminary injunction, the New York AG would have a clearer path for securing a state court geofencing order against Kalshi, Coinbase, and Gemini Titan. 2:08 AM · Sep 13, 2026 · 4.78K Views 1 Reply · 2 Reposts · 8 Likes ](https://x.com/WALLACHLEGAL/status/2098957043474280584?s=20) Gaming Commission remains member of gambling council after questions raised over ties to Kalshi (Mass Live): “The Massachusetts Gaming Commission will not follow the leads of gaming regulators in Ohio and Michigan and drop ties with the National Council on Problem Gambling over its new association with Kalshi.” Sponsor’s messageTrusted Voices: Conversations About Betting is designed to equip adults, including parents and coaches, with tools and resources to talk to young people about gambling, including information on warning signs, risks and proxy betting. The program is led by retired professional basketball player Randy Livingston and his wife, basketball agent Anita Smith, who share their personal stories related to problem gambling, with the hope of preventing others from experiencing similar harms. Learn more and join the conversation here. 📣 Industry news Gaming M&A: Latest Mergers, Acquisitions and Deals (SBC Americas): “But what else is happening in the world of gaming mergers, acquisitions, investments, and partnerships? Here, we round up some of the news you might have missed.” BetMGM Named Official Sports Betting and Online Casino Partner of the Minnesota Vikings in Canada (press release): BetMGM, a leading iGaming and sports betting operator, announced a multi-year partnership with the Minnesota Vikings, naming it the Official Sports Betting Partner and Online Casino Partner of the team in Canada. The agreement gives BetMGM rights to use Vikings marks across approved sports betting, online casino and marketing activities in Canada. In addition, Vikings Big Kick LuckyTap™, a casino game by Design Works Gaming, is available now exclusively at BetMGM Casino in Alberta and Ontario. “Vikings fans bring a level of passion and loyalty that extends well beyond game day,” said Matt Prevost, Chief Revenue Officer at BetMGM. “As the home of one of the largest collections of sports-themed casino content in North America, BetMGM is uniquely positioned to combine sports fandom with iGaming. We are eager to start football season off strong with another fantastic partnership especially as we expand our reach in Canada to Alberta.” Martin Nance, Minnesota Vikings Chief Marketing Officer, said, “As we continue to deepen our connection with Vikings fans across Canada, we’re proud to welcome BetMGM as the team’s official sports betting and online casino partner in Canada. Their commitment to innovation and fan engagement aligns well with our organization, and we’re excited to create memorable experiences that celebrate Vikings football and connect with Canadian fans in new and meaningful ways.” Caesars Entertainment Launches Ball Rush Jackpots™ in New Jersey,the Latest Proprietary Online Title from Empire Creative™ (press release): Caesars Entertainment, Inc. (NASDAQ: CZR) (“Caesars”) today announced the launch of Ball Rush Jackpots™, a new ball-and-peg style online casino game developed by Empire Creative™, the Company’s in-house game development studio. Now live in New Jersey across Caesars Palace Online Casino, Caesars Sportsbook & Casino and Horseshoe Online Casino, Ball Rush Jackpots is expected to become available in additional jurisdictions where Caesars offers online casino gaming following regulatory approval. The title expands Caesars’ growing portfolio of proprietary online casino titles, following the successful launch of Ca$hline™ earlier this year and further diversifying the Company’s lineup beyond traditional slots and table games. Ball Rush Jackpots follows the traditional ball-drop gameplay experience where players drop a ball down a board filled with pegs to land in a prize slot. As balls navigate independently through a field of pegs, every drop creates new opportunities to collect feature symbols, unlock bonuses and pursue jackpots, delivering a different experience with every round. “Ball Rush Jackpots delivers a different kind of casino experience for our players, combining easy-to-understand gameplay with meaningful customization, exciting bonus opportunities and jackpot potential,” said Matthew Sunderland, Senior Vice President and Chief iGaming Officer at Caesars Digital. “As we continue expanding our proprietary content portfolio, we’re focused on creating games that are simple to pick up, rewarding to revisit and designed around the features players enjoy most.” Bally’s Corporation Secures New Financing to Support the Development of the Bally’s Bronx Project (press release): Bally’s Corporation (NYSE: BALY) (“Bally’s” or the “Company”) announced today that it secured new financing led by WhiteHawk Capital Partners, LP to fund further development of the Bally’s Bronx project and general corporate purposes. The new financing comprises closing date term loan commitments in an aggregate principal amount of $400 million and delayed draw term loan commitments in an aggregate principal amount of $160 million (together, the “Facilities”). … Bally’s Chairman of the Board, Soo Kim, commented, “This important financing allows us to progress the pre-construction planning process so that we are ready to complete the remainder of the capital raise and remain on schedule. Furthermore, the additional liquidity provides us greater flexibility for other capital opportunities.” WORLD JAI ALAI LEAGUE LAUNCHES CENTENNIAL SEASON AND ENTERS NEXT CHAPTER IN MIAMI (press release): The World Jai Alai League will open its 2026 fall season on Tuesday, September 15 at Miami’s JAM Arena, beginning a milestone season that marks 100 years since professional Jai Alai first arrived in Miami. Season X, the tenth season of the Battle Court team-based competition launched in 2022, will also be the first since entrepreneur and sports asset investor Rob Gough acquired the World Jai Alai League in August 2026. The acquisition marks the beginning of a new chapter for the league. World Jai Alai League will maintain the existing Battle Court competition and operating format, with Chief Operating Officer Scott Savin overseeing Season X. Gough and his team will use the coming months to listen to players and fans, evaluate opportunities across the league, and execute plans for a broader evolution of Jai Alai’s presentation, live experience, media, marketing and commercial strategy beginning in 2027. “This is a really unique moment for Jai Alai,” said Rob Gough, Owner of the World Jai Alai League. “We have a sport with more than 100 years of history in Miami, extraordinary athletes and incredible speed, but I also believe there is enormous untapped potential.” bet365 reveals most popular online slots in 3 US states in August (SBC Americas): “In its monthly Gaming Insights and Performance report, growing online casino operator bet365 tracks player trends and game performance in online slots across its North American online casino markets.” The Closing Line is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe

Sep 14 • 2:45 PM EDT • Entertainment • closingline.substack.com

‘Staying Present’ Became the Gift the Connecticut Sun Needed

There are two home games to go until the end of the Connecticut Sun era. Headlines have been made both on and off the court this season, making it essential to choose which memories and moments to keep. How much of these moments should be about each of the team’s “lasts”s? Tuning Out the Noise […] The post ‘Staying Present’ Became the Gift the Connecticut Sun Needed appeared first on The Lead.

Sep 14 • 2:26 PM EDT • Sports • sports.yahoo.com

First AI Sciences Major at Idaho State Blazes His Own Trail

First AI Sciences Major at Idaho State Blazes His Own Trail

Sep 14 • 1:48 PM EDT • Science • isu.edu

Stagecoach 2027: Garth Brooks, Zach Top and Riley Green will headline

LOS ANGELES — Garth Brooks, Zach Top and Riley Green will headline 2027’s Stagecoach country music festival, organizers announced Monday, bringing together one of the genre’s veteran standard-bearers with two

Sep 14 • 1:25 PM EDT • Entertainment • recorderonline.com

The ladies of the Flew Here, Grew Here podcast discuss entertainment headlines

Lady Gaga is a mom, and the Nashville airport will be named after the late great Dolly Parton. The ladies dish on these headlines and more with Alex.

Sep 14 • 11:13 AM EDT • Entertainment • fox5atlanta.com

The Craft of Peer Review

Peer Review Week provides an opportunity to recognize the volunteer reviewers whose time and expertise are essential to the scientific publishing process. To mark the occasion, AMS asked recipients of…

Sep 14 • 11:11 AM EDT • Science • headlines.ametsoc.org

Most Canadian Small Businesses Haven’t Felt AI’s Impact, Survey Shows

Second-wave findings from Zensurance’s 2026 survey show three-in-five small business owners remain outside the AI conversationTORONTO, Sept. 14, 2026 (GLOBE NEWSWIRE) -- While artificial intelligence dominates the headlines and boardroom discussions, most Canadian small business owners say it has not meaningfully changed the way they operate. New findings from the 2026 Zensurance Small Business Confidence Index show that the frontier technology remains largely in the background for the majority

Sep 14 • 9:37 AM EDT • Business • finance.yahoo.com

Lone Star Politics: Sept. 13, 2026

Lone Star Politics is looking at the big headlines from the RNC midterm convention. Plus, a sit down conversation with U.S. Treasury Secretary Scott Bessent.

Sep 14 • 4:18 AM EDT • Politics • nbcdfw.com

Conor McGregor Trashes Max Holloway For Wanting Fight to End

UFC superstar Conor McGregor trashed rival Max Holloway for wanting the referee in their fight at UFC 329 to end it.McGregor tore his ACL against Holloway in the UFC 329 headliner. The fight went on until Holloway pointed out McGregor’s injury to referee Mike Beltran, who soon stopped the contest.Now, the Irishman is saying he […] The post Conor McGregor Trashes Max Holloway For Wanting Fight to End appeared first on HEAVY.

Sep 13 • 11:13 PM EDT • Sports • sports.yahoo.com

WHAS11

WHAS11 (Louisville) is your source for breaking news, Kentucky weather, traffic, and live coverage in Louisville and across Kentuckiana. Get the latest updates from the WHAS11 team — from major local headlines and investigations to severe weather, community stories, and the moments everyone’s talking about. Watch live newscasts, stream breaking coverage, and catch up on the top stories shaping Louisville, Southern Indiana, and communities across the region. Subscribe for: • Louisville breaking news + live updates • Kentucky and Southern Indiana weather forecasts and severe weather alerts • Investigations and accountability reporting • Community stories across Kentuckiana • Major events, sports, and local explainers WHAS11 — Louisville news and weather, live and on demand. 🔗 More: https://www.whas11.com

Sep 13 • 11:09 PM EDT • Business • youtube.com

KHOU 11

KHOU 11 (Houston) is your source for breaking news, Texas weather, traffic, and live coverage in Houston and across Southeast Texas. Get the latest updates from the KHOU team — from major local headlines and investigations to severe weather, community stories, and the moments everyone’s talking about. Watch live newscasts, stream breaking coverage, and catch up on the top stories shaping Houston, Sugar Land, The Woodlands, Galveston, and surrounding communities. Subscribe for: • Houston breaking news + live updates • Texas weather forecasts, storms, and severe weather alerts • Investigations and accountability reporting • Community stories across Southeast Texas • Major events, sports, and local explainers KHOU — Houston news and weather, live and on demand. 🔗 More: https://www.khou.com

Sep 13 • 8:24 PM EDT • Politics • youtube.com

11Alive

WXIA (Atlanta) — 11Alive is your source for breaking news, Georgia weather, traffic, and live coverage in Atlanta and across the metro area. Get the latest updates from the 11Alive team — from major local headlines and investigations to severe weather, community stories, and the moments everyone’s talking about. Watch live newscasts, stream breaking coverage, and catch up on the top stories shaping Atlanta, Marietta, Sandy Springs, Decatur, and surrounding communities. Subscribe for: • Atlanta breaking news + live updates • Georgia weather forecasts, storms, and severe weather alerts • Investigations and accountability reporting • Community stories across the metro area • Major events, sports, and local explainers WXIA / 11Alive — Atlanta news and weather, live and on demand. 🔗 More: https://www.11alive.com

Sep 13 • 6:42 PM EDT • Politics • youtube.com

KGW News

KGW is the NBC TV affiliate in Portland, Oregon, delivering the latest news, weather, traffic and sports for Oregon and SW Washington on TV, online at kgw.com and on mobile via the free KGW News app: on.kgw.com/app Check our channel every Friday for a new Oregon adventure from Grant's Getaways. Every week, look for a new in-depth political discussion on Straight Talk with Stephanie Domurat. And every day you can get headlines on demand with the Top Stories from our newscasts!

Sep 13 • 2:34 PM EDT • Health • youtube.com

Did Scientists Just Witness a Key Step in the Origin of Complex Life?

A recent headline suggests a breakthrough. Have researchers recently witnessed experimental support for the origin of complex life?

Sep 13 • 8:00 AM EDT • Science • answersingenesis.org

Noche UFC 4 Bonuses! McMillen Banks $100K Yet Again

Jean Silva had to push through some early adversity earlier tonight (Sat., Sept. 12, 2026) at Noche UFC 4 LIVE on Paramount+ from inside Desert Diamond Arena in Glendale, Arizona, but the featherweight powerhouse eventually scored a main event submission finish over Jose Delgado (see it HERE). In addition to the featherweight headliner, Noche UFC […]

Sep 12 • 9:03 PM EDT • Sports • sports.yahoo.com

😅 Too much TikTok?! Bundesliga captain’s words backfire

Just last week, Gladbach captain Tim Kleindienst made plenty of headlines when he launched a broadside after the defeat against promoted side Elversberg — and it was aimed at his own teammates. He e...

Sep 12 • 10:57 AM EDT • Sports • sports.yahoo.com

The politics and possibilities of ‘AI could kill us all’

I found myself fielding a lot of questions from folks who don’t usually talk much about AI this week. They were mostly along the lines of “do you think AI is going to kill us all?” or “how worried should I be about this human extinction stuff?” Motivating this wave of existential anxiety was the highly dramatic resignation of now-former Anthropic employee Jacob Coxon, who quit his job while publicly sharing his concerns about safety practices at the leading AI companies. More specifically, he declared that almost everyone at OpenAI and Anthropic, the leading AI labs, believes that there’s a decent chance the AI systems they’re producing could “kill us all” by the end of the decade, and the companies aren’t “acting responsibly.” Other AI safety researchers, including those still employed at Anthropic and OpenAI, all confirmed that yes, Coxon is correct, they’re all worried that their company’s products might prove fatal for the entire human race as well. Two more AI employees quit and joined the chorus. Now, the warning shot has been covered everywhere from the Wall Street Journal to Fox News to WIRED to the Guardian. I understand why all this sounds scary, but my response to those who have asked, has generally been: No, you don’t need to worry that AI will kill go rogue and kill us all. But that does not mean we shouldn’t worry, period. Far from it. The companies building AI products are now among the wealthiest and most powerful entities in the world. And they very much are building enormous engines of mass surveillance, extraction, and automation. They can and have allowed their AI systems to carry out felony hacks of other companies, provided the government with autonomously generated kill lists, and sold enterprise technology to firms around the world that is explicitly intended to replace jobs. But “AI” has done these things not because they have all-powerful minds of their own but, ultimately, because people have programmed, calibrated, and directed them to. In other words, it’s not AI we need to worry the most about. It’s the people and corporations working to profit from and gain power by deploying it. The technology is sophisticated, sure, and, especially in cybersecurity contexts, potentially disruptive to plenty of existing systems. But if we want to stop this predatory, profiteering, and extractive form of AI—and it’s worth noting that at this point, most people do—we absolutely can. A quick note/plea: I can only do all of this with the support of readers like you, so if you find value in independent, critical tech journalism and analysis, please consider becoming a paid subscriber. I want to keep as much of this un-paywalled as absolutely possible, and I need your support to do so. Many thanks to all who continue to chip in, it’s very much appreciated. Onward. Subscribe First, some context: AI industry folks like Coxon have been discussing the prospect that AI will destroy humanity for years. Even before the beginning of the AI boom, many working in the industry, from the executive staff to the rank and file researchers, have obsessed over ‘x-risk’, or the possibility that AI will become sentient or semi-sentient and move one way or another to exterminate humanity. This is ostensibly why Elon Musk bankrolled OpenAI in the first place, and is the grounds for his lawsuit alleging OpenAI betrayed its charter by abandoning its nonprofit status to become a commercial enterprise. Many AI engineers and startup founders have calculated their own personal p(doom), or the probability that the tech product they are working on will initiate an actual humanity-extinguishing apocalypse. 10-25% p(doom)s are pretty common. (I wrote about a long weekend I spent among these folks at one of their top conferences here, to give you an idea of their ideas and belief systems.) Sam Altman himself drove the narrative of the imminent rise of a super-powerful AI, or artificial general intelligence, to prominence by declaring that the technology he was building posed an existential risk to humanity. This idea is in other words baked into the DNA of modern AI companies and into the products they engineer. It’s also why the industry is routinely accused, by myself and others, of “doom marketing,” ie, using such proclamations and framings to impart the sheer power of the technology behind your product onto investors, partners, consumers, and the state. Some ambient understanding of this tendency may have helped prevent the press from repeating the claim every time one of the x-risk folks made it over the years, including when they quit their jobs at AI companies while doing so. Yet Coxon’s AI x-risk alarm has broken containment, as they say, and has exposed the idea to the mainstream media once again. This has happened, I think, for a number of reasons. First, when AI CEOs were going around saying AI might kill everyone in 2023, their companies were well-capitalized, but not nearly to the extent they are today. They were more easily dismissed as eccentric geeks of the sort that Silicon Valley is supposed to produce. Now, not only do their products have much greater market saturation, but people are more aware of a) the often unethical ways the executives and companies comport themselves b) the other adverse impacts of AI that have already arrived, and c) the physical cost of building these systems, particularly when it comes to data centers. Finally, toss in the constant stream of headlines in 2026 about AI models going rogue or potentially upending the world’s infrastructure. [ ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) [ With the backlash to data centers, Flock and AI glasses, a mass opposition to big tech is underway. Silicon Valley is in denial. ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) Brian Merchant · Aug 27 [ Read full story ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) As a result, general sentiment was already overwhelmingly skeptical of AI and its overlords, so the table was pretty well set for someone to come along and say ‘just a reminder, the companies that are building the product that promises to take your job and leave a data center in your neighborhood also think that it might exterminate the human race’ and get a strong reaction from the media and the public. The question is: Should we understand this stuff as hype, strategically fanned to feed already swelling valuations? Is it doom marketing? Genuine cause for alarm that the infrastructure that undergirds modern life is facing a novel threat vector? Or reason to be sincerely worried that AI companies are amassing too much power, and that their products are genuinely dangerous? The answer, I’m afraid, is “yes.” Let me try to untangle all of this a bit, because arguments over how to navigate this moment are extremely heated right now, as they are essentially arguments over how to approach the politics of AI at a moment where there may be a unique opening for action. Those sympathetic to AI alignment concerns and x risk arguments—which increasingly includes a faction on the left who want to shut down AI over safety concerns—argue that people who dismiss AI as all hype have their heads in the sand. Meanwhile, critics of the x-risk narrative—which I might note includes a cadre of investors and tech folks on the right, too—argue that it is hype and can be used to further inflate valuations or for pursuing regulatory capture. The challenge is that many feel that dismissing AI as just hype or purely marketing also diminishes the urgency of taking on the AI industry as the novel and threat to labor, civil society, and the public sphere it is; others that by accepting the industry’s own terms, we imbue it with undue power and enable it. But let’s be clear: Declarations that AI is so powerful it might end the world are a kind of marketing, and anyone who says otherwise is just as off base as those who say that’s all that it is. If you don’t think that these sub-trillion dollar companies have higher-ups who noticed that when their founders talked about super-powerful dangerous AI they got spikes in media interest and phone calls from investors, or that those founders didn’t notice that themselves, and lean into certain narratives to advantage their products, then I don’t know what to tell you. Not all marketing is a Pepsi ad campaign with a celebrity spokesperson. Yet confronting the AI industry should certainly be considered an urgent project. Do I share the x-riskers’ fear that out-of-control, super-intelligent AI agents might end the world? I do not. I’ve read a good deal of AI extinction literature over the last couple of years and I have not come across a credible, step-by-step documentation of how exactly AI might move from self-recursively improving AI to killing every single human on the planet. Most of what I’ve read seems predicated on a sort of reverse Ian Malcolmian logic: Eventually, it becomes smart enough and AI, uh, finds a way (to exterminate humanity). Are the AI companies also overstating and dramatizing what their products can do? Yes, pretty much all the time. They’re in a knife fight for market share and are trying to win customers and government contracts before their investors come knocking. And yet. They have concentrated enormous amounts of compute, have extensive data collection and surveillance capacities, have inserted themselves into the state in numerous capacities, including military kill chains, and they are being run by egomaniacal billionaires who are rushing to monopolize an entire new market. The way I think about their most recent frightening-seeming exploits is not as a “swarm of rogue AI agents building a new civilization” or whatever, but as corporations with a hitherto-unimaginable amount of compute at their disposal recklessly experimenting with automation programs, completely unafraid of any repercussions because we have been unwilling or unable to impose any on them. So I think we should welcome any newfound imperative to hold them accountable. I also think that ultimately, the AI critics, Pause AI folks, leftists, doomers, effective altruists, and, honestly, most of the public, want a lot of the same things: legitimate checks and limits on AI companies’ power, actual transparency into what the companies are doing, and for more of AI to be under public control. (Ultimately, a lot of what animates the x-risk fears are rooted in just that: a fear of losing control.) How we move towards all this, exactly, is the question of the day, and while there’s much to be argued over in terms of building a viable political platform to challenge the AI industry’s power, I do want to cast a vote against one particular approach. Not to pick on Chris here, as there are a lot of folks out there proposing stuff like this, and the policy ideas actually stem from AI safety groups. But not only would this be challenging to land politically (I can already hear the ‘China will beat us to AGI’ calls) and all but unworkable in practice, this approach is a) far too limiting, b) fails to address the current harms caused by AI and c) would likely only wind up serving Anthropic and OpenAI; it’s what regulatory capture looks like in action. Full model transparency is the floor for what should be on offer here. If these companies believe their products will kill us, the very least we deserve is to know how. It’s in the public interest. I would also argue we might get a lot of the way to stopping any currently envisioned robot apocalypse simply by forcing AI companies to assume liability, and to submit to the full brunt of the law. If Sam Altman were liable to be charged with a felony for approving the hack on Hugging Face1, if Google was forced to pay defamation fines each time it published a false and injurious AI Overviews, these companies might suddenly find cause to restrain their models’ output, and we might hear less about rogue AI. We would need to introduce new frameworks and available tools for tracking automated lawbreaking, to be sure, but I’d wager that little would frighten the AI companies more than actually being held accountable for what their products enable. To that end, Illinois has passed an AI liability law, which the industry fought tooth and nail, and Florida is considering one. The next steps would be towards moving AI under public control; again, it’s only reasonable, since everyone, not just AI insiders, should get a say over how a technology whose developers say might kill us is developed and deployed. Dismantling the whole industrial project as currently structured should be on the table, too, pending democratic input. But that’s for another post. For now, suffice to say that while I won’t be losing any sleep about an AI-enabled extinction event, Mr. Coxon and co. have given us an opportunity to underscore the urgency of the clear and present damage AI companies are doing, the extreme power they wield and the extent to which they hold themselves unaccountable, and the abundance of political capital there is out there for taking them on. Subscribe 1 Purely speculative! I do not know if he did or not.

Sep 12 • 3:59 AM EDT • Politics • bloodinthemachine.com

KGW News

KGW is the NBC TV affiliate in Portland, Oregon, delivering the latest news, weather, traffic and sports for Oregon and SW Washington on TV, online at kgw.com and on mobile via the free KGW News app: on.kgw.com/app Check our channel every Friday for a new Oregon adventure from Grant's Getaways. Every week, look for a new in-depth political discussion on Straight Talk with Stephanie Domurat. And every day you can get headlines on demand with the Top Stories from our newscasts!

Sep 11 • 8:24 PM EDT • Business • youtube.com

Alliance Entertainment (AENT) Stock Jumps On Revenue Growth Despite Q4 Loss

The market cheered Alliance Entertainment Holding on Friday. The stock jumped 16.5% to US$6.42, extending an already strong three month run, as traders focused on the headline of double digit full year revenue growth to about US$1.15b. Under the surface the story is sharper. Investors are reacting to Q4 top line acceleration to US$268.1m and to management’s focus on higher margin physical formats and collectibles. At the same time, the quarter swung to a net loss of US$3.5m, a reminder that...

Sep 11 • 6:34 PM EDT • Entertainment • simplywall.st

Fox News Entertainment newsletter: King Charles shuts down Harry and Meghan; Prince George starts at Eton

The Fox News Entertainment Newsletter brings you the latest Hollywood headlines, celebrity interviews and stories from Los Angeles and beyond.

Sep 11 • 6:20 PM EDT • Entertainment • wfmd.com

Ocean Way canceled due to hurricane: Santa Monica beach festival is no more

Ocean Way, the groundbreaking beachfront Santa Monica music festival, has been canceled just two weeks before debuting. It was slated for headline sets by the Killers and Olivia Dean.

Sep 11 • 5:32 PM EDT • Entertainment • latimes.com

Fox News Entertainment newsletter: King Charles shuts down Harry and Meghan; Prince George starts at Eton

The Fox News Entertainment Newsletter brings you the latest Hollywood headlines, celebrity interviews and stories from Los Angeles and beyond.

Sep 11 • 5:27 PM EDT • Entertainment • foxnews.com

SouthCoast High School Football Week 1 schedule, scores and highlights

There are a pair of all-local matchups that headline Week 1 action for SouthCoast football. Follow our scores throughout the night right here.

Sep 11 • 4:00 PM EDT • Sports • sports.yahoo.com

What Today's Business Grants Reveal About Tomorrow's Funding Opportunities

Colorful GrantWatch promotional graphic featuring a winding road leading toward a bright city skyline at sunrise. A large white arrow on the road points toward “Tomorrow’s Opportunities.” On the left, a signpost displays funding focus areas including Innovation, Clean Energy, Workforce Development, Community Growth, and Small Business. The headline reads, “What Today’s Business Grants Reveal About Tomorrow’s Funding Opportunities.” The GrantWatch logo and “Time to Apply” appear at the top. In the lower right corner, a stack of books labeled “Plans” and “Grants” is topped by The Queen of Grants 2 by Libby Hikind, reinforcing the theme of planning for future grant funding opportunities.

Sep 11 • 10:49 AM EDT • Business • grantwatch.com

Analytics and Data Science News for the Week of September 11; Updates from Alteryx, OpenAI, University of Cincinnati & More

Solutions Review Executive Editor Tim King curated this list of notable analytics and data science news for the week of September 11, 2026. Keeping tabs on all the most relevant analytics and data science news can be a time-consuming task. As a result, our editorial team aims to provide a summary of the top headlines […]

Sep 11 • 10:25 AM EDT • Science • solutionsreview.com

Why vacant offices are still one of NYC's top housing strategies

Safety issues at NYC office-to-apartment projects have made headlines this summer. The city still needs them for housing supply.

Sep 11 • 5:30 AM EDT • Business • businessinsider.com

7 Takeaways From the Republican Midterm Convention

On the second night of the Republican gathering in Dallas, Vice President JD Vance was the headliner. But President Trump returned to center stage.

Sep 11 • 12:13 AM EDT • Politics • nytimes.com

The Not-So-Secret Winner in Netflix and YouTube’s Streaming Wars Battle

(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) Here’s a good piece of advice: when someone tells you a company has “won” the streaming wars, just assume they haven’t. Remember the narratives about the streaming media over the last few years: 2024 - Netflix has won the streaming wars! 2025 - YouTube has won the streaming wars! Yet…in 2026, I’d categorize it as… 2026 - Netflix and YouTube are battling for talent! Netflix and YouTube are aggressively fighting for top creators, marking a fierce new battle in the streaming wars. For two companies that “won”, that certainly doesn’t seem like winning behavior. If you win, you don’t have to fight for talent, because talent has to come to you. This is a good reminder that, if the streaming wars are a war—and I think they are—we should know what type of war they are. So it’s worth revisiting one of my big theories of the streaming wars, that the war these battles most represent is… The Thirty Years’ War1 I prefer this war to other, simpler wars, because, while it featured two “sides”—based on religion—and the current war has two main sides—tech versus entertainment—it also featured a lot of smaller players battling it out, sometimes switching sides. And that’s still the case for entertainment and media, despite the above headlines. I’d recommend this truism: if someone has to tell you they won the streaming wars, they probably haven’t. To wit, if someone told you they were fighting in the Thirty Years’ War—and no, they didn’t call it that at the time—and in year five, they told you they won, well, obviously they had 25 more years to go. That’s a lot of preamble to say, the story of the week is the latest battles between YouTube and Netflix. Their battle for talent says a lot about how hard this war will be to win. All that, plus The Curse of the Mogul in action, Netflix providing more (theatrical) data, whether Apple TV is in trouble, AMC getting in on distribution, and a whole lot more. Subscribe Today’s article is sponsored by… Substack is hosting a live Emmys watch party, starting at 5PM on the East Coast (2PM on the West Coast) on Monday, 14-Sep. Check it out! Tune In Most Important Story of the Week - Who’s the Big Winner in the Netflix vs YouTube Showdown? Netflix spent a lot in 2025, and then even more in 2026 adding a host of “creators”—both podcasters and YouTube stars—to their TV lineup. Frankly, for years, I’ve thought that more major studios/streamers/channels should look to YouTube as the launching pad for future stars and IP. Either by poaching proven talent—albeit at good prices—or by treating YouTube as an arena for your “A&R” reps to scout new talent and emerging voices. Netflix started executing the former strategy—which I thought was smart—while Focus Features did the latter with Obsession. So what changed? YouTube finally responded! Yikes. That’s a strong response, and stronger than I’d argue most narratives about YouTube suggest. People often describe YouTube as a self-reinforcing flywheel of success. Get on YouTube or perish. So why did YouTube have to respond? Because other folks poaching their top talent could really damage their business, implying their flywheel is a pinch more rickety than most analysis suggests. Clearly, creators can envision a life off YouTube and potentially a much more lucrative one. The Curse of the Media Mogul is Playing Out In Real Time We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… Who is the big winner in the Netflix versus YouTube battle… The biggest question about YouTube… Plus why YouTube’s saber rattling should worry talent… Why I’m skeptical that a U.S. federal tax credit for film will happen… What key change could pull Apple from the streaming business. AMC getting in on distribution… Some great reads on the Warner Bros.-Paramount merger... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support.

Sep 10 • 5:34 PM EDT • Entertainment • entertainment.substack.com

Gorilla Heavy Hitters hosts Night of Champions in Midland

ODESSA, Texas (KMID/KPEJ) – This weekend, local boxing promotion Gorilla Heavy Hitters will be hosting its “Night of Champions” event. Multiple local boxers will be featured, showcasing West Texas talent, as Big Belt Champion and featherweight contender Conrad Martinez headlines the main event, facing off against the undefeated (15-0 13 KO) Victor “Jalapeno” Hernandez. Night […]

Sep 10 • 4:45 PM EDT • Sports • sports.yahoo.com

Anger Over Health Costs Clouds Midterms

Amid a campaign already focusing on affordability, anxious voters are unlikely to be assuaged by headlines about healthcare costs rising even more next year. And a lawsuit that could cut off access nationwide to the abortion pill mifepristone gets a hearing in federal court. Joanne Kenen of the Johns Hopkins Bloomberg School of Public Health and Politico Magazine, Sandhya Raman of Bloomberg Law, and Amanda Seitz of KFF Health News join KFF Health News’ Julie Rovner to discuss these stories and more. Also this week, Rovner also interviews Lauren Sausser, who wrote the latest KFF Health News “Bill of the Month.”

Sep 10 • 3:05 PM EDT • Health • kffhealthnews.org

Healing, community take center stage at Madison's Mental Health Warrior Film Festival

Festival headliner, “Afterglow,” is a documentary about a group of parkour athletes from Beloit that explores trauma, belonging and the power of movement.

Sep 10 • 1:07 PM EDT • Health • wpr.org

WFAA

WFAA (Dallas–Fort Worth) is your source for breaking news, Texas weather, traffic, and live coverage in Dallas, Fort Worth, and across North Texas. Get the latest updates from the WFAA team — from major local headlines and investigations to severe weather, community stories, and the moments everyone’s talking about. Watch live newscasts, stream breaking coverage, and catch up on the top stories shaping Dallas, Fort Worth, Arlington, Plano, and surrounding communities. Subscribe for: • Dallas–Fort Worth breaking news + live updates • Texas weather forecasts, storms, and severe weather alerts • Investigations and accountability reporting • Community stories across North Texas • Major events, sports, and local explainers WFAA — Dallas–Fort Worth news and weather, live and on demand. 🔗 More: https://www.wfaa.com

Sep 10 • 11:11 AM EDT • Health • youtube.com

Kentucky governor to headline Democratic rally

Gov. Andy Beshear, D-Kentucky, will headline a Democratic Party of Arkansas dinner on Oct. 1 at North Little Rock’s The Venue at Westwind. The “Ballots, Blue Jeans & BBQ” event...

Sep 9 • 10:56 PM EDT • Politics • talkbusiness.net

Detroit Tigers and Florida Poly Collab Creates Opportunities in Sports Science

New partnership will embed Florida Poly faculty with the Tigers’ Performance Science group, driving research in data science, sport analytics, and performance science.

Sep 9 • 6:30 PM EDT • Science • lkldnow.com

Comedy headliners jam the metro area this weekend

This weekend is loaded with headliners in larger theater settings, making for a particularly busy time for comedy fans.

Sep 9 • 2:38 PM EDT • Entertainment • theoaklandpress.com

Bruce Lunsford through the years: Our photos of Louisville businessman

Bruce Lunsford made plenty of headlines over the years in Louisville and around Kentucky. Check out photos from The Courier Journal's archives.

Sep 9 • 9:50 AM EDT • Politics • courier-journal.com

Rory McIlroy Headlines Star-Studded 2026 Irish Open at Doonbeg

Rory McIlroy defends his Irish Open title at Doonbeg against Jon Rahm, Shane Lowry, Brooks Koepka and one of the event’s strongest recent fields.

Sep 9 • 8:00 AM EDT • Sports • sports.yahoo.com

John Fetterman, Marjorie Taylor Greene will headline TribFest

Two of American politics’ most unique and least predictable voices bookend our three days of live journalism.

Sep 9 • 7:30 AM EDT • Politics • texastribune.org

Paul Finebaum rips Geno Auriemma on state of college sports

Auriemma made headlines last week for his belief that college sports are "dying."

Sep 9 • 5:00 AM EDT • Sports • ctinsider.com

Brendan Schaub Trashes UFC 332 Main Event

Former UFC heavyweight fighter Brendan Schaub trashed the upcoming UFC 332 main event between Natalia Silva and Wang Cong.With Valentina Shevchenko out for one year due to injury, she was forced to vacate the UFC women’s flyweight title, so Silva and Wang will now fight for the undisputed strap in the UFC 332 headliner.It’s a […] The post Brendan Schaub Trashes UFC 332 Main Event appeared first on HEAVY.

Sep 8 • 11:50 PM EDT • Sports • sports.yahoo.com

Can the 'best showman in politics' deliver again? GOP bets on Trump at historic midterm convention

Donald Trump headlines the first-ever GOP midterm convention in Dallas, aiming to energize low-propensity MAGA voters ahead of key 2026 races.

Sep 8 • 10:43 PM EDT • Politics • foxnews.com

Apple Event Tomorrow: iPhone 18 Pro and iPhone Ultra Cheat Sheet

Apple's biggest event of the year is almost here, and all eyes are on Cupertino. With the first foldable iPhone expected to headline Apple's "Surprise and Shine" event on Wednesday, September 9, at 10:00 a.m. Pacific Time, the rumor mill has been running full throttle, fuelled by the biggest single design change in the life of the iPhone.

Sep 8 • 1:24 PM EDT • Technology • macrumors.com

National politics roundup

We’re digging into all the top headlines with local commentators on either side of the .

Sep 8 • 12:00 PM EDT • Politics • whyy.org

NFL Announces Halftime Act for Detroit Lions Munich Game

The NFL has announced Cage The Elephant as the halftime headliner for the Detroit Lions’ Nov. 15 game against the New England Patriots in Munich.

Sep 8 • 11:41 AM EDT • Sports • sports.yahoo.com

Christal Jordan has the latest in entertainment headlines

The Duke & Duchess of Sussex are back in the UK, and Phaedra Parks has a new beau. Keep up with Christal on social media @threalchristaljordan

Sep 8 • 11:11 AM EDT • Entertainment • fox5atlanta.com

Christal Jordan has the latest in entertainment headlines

Sep 8 • 11:11 AM EDT • Entertainment • yahoo.com

AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.

Sep 8 • 10:50 AM EDT • Science • fiercebiotech.com