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AI helps US businesses manage Supreme Court tariff impacts
Generative AI aids US importers with tariff refunds and scenario planning. KPMG and EQI use AI tools to navigate trade compliance and optimize costs.
School of Business receives AACSB Global Impact Award for use of AI in teaching and learning
The School of Business has been recognized as a winner of AACSB’s inaugural Global Impact Awards for creative and effective use of generative AI in teaching and learning. The Global Impact Awards honor individuals and institutions whose initiatives exemplify innovation, leadership, and measurable impact in business education and [...]
3L Rachel Sadler Charts Path in Brain Health, Technology, and Policy Through UC Law SF’s Health Law Concentration - UC Law San Francisco (Formerly UC Hastings)
3L Rachel Sadler studies health law and policy at UC Law SF while researching the legal implications of neurotechnology and other emerging tools that may affect human cognition. 3L student Rachel Sadler shares how UC Law SF’s Health Law Concentration prepared her for a career focused on the intersection of brain health, government policy, and technology. Gained a detailed understanding of how U.S. health care is regulated and where policy reform is needed through coursework and research. Interned with state and federal agencies that regulate health care services and worked with a major health care provider’s bioethics department. Plans to pursue a career focused on protecting cognitive liberty and mental privacy as new technologies reshape healthcare. 3L Rachel Sadler: The Health Law Concentration has given me fluency in one of the most complex regulated industries and the tools to become an effective advocate for better health policy. Before coming to law school, I spent a decade teaching and working with teachers and administrators on high school programming for multilingual learners. Healthcare kept emerging as the most powerful driver of student outcomes. I wanted to understand how to make effective policy change in this area and how to use existing law to defend people’s health rights in California. Through the concentration’s coursework, I gained a sophisticated understanding of how U.S. healthcare is regulated. I also learned where the pressure points for reform exist. The courses gave me space to develop what became my central research interest: how law and policy can be built to protect human cognition and healthy brain development, particularly regarding new technologies such as generative AI and neurotechnology. The health law faculty were instrumental in that process, genuinely invested in helping me and other students define and pursue our own intellectual vision. During law school, I interned at the General Counsel’s Office for Region IX of the U.S. Department of Health and Human Services. I also externed at the California Department of Justice’s Health, Education and Welfare Division. Additionally, I externed at Kaiser Permanente Northern California’s Bioethics Department. Alongside those placements, I conducted extensive independent research on mental privacy and emerging neurotechnology, working closely with Professors Emily Murphy and George Horvath. That research became the throughline of my law school experience and the foundation of my current policy focus. I must also credit Nicole Ozer of the Center for Constitutional Democracy (CCD), whose deep knowledge of California privacy law and the public-interest privacy landscape deeply informed my work. I currently serve a research assistant with the CCD, where I spearhead the development of K-12 educational resources in partnership with law faculty and students. I’ve found UC Law SF to be an ideal place for second-career, nontraditional students. There is a tremendous diversity of life and career experience here, and I felt fully welcomed into the community, despite returning as a student at a different stage of life. I came to law school wanting to promote equity in California’s healthcare system. I am leaving with a sharper and more specific ambition: to build a policy career focused on protecting cognitive liberty and mental privacy from technological intrusion. This is both an urgent and underserved area of law, and I want to be part of defining this landscape going forward. Whether as a practicing attorney or a policy advisor, I plan to work on these issues after law school. I strongly recommend UC Law SF and the Health Law Concentration. When I arrived in law school, I worried the concentration would be narrow and that my non-clinical background would be a disadvantage. The opposite was true. The health law faculty thinks about health expansively, encompassing social determinants of health, structural inequity, and emerging technologies alongside the regulatory mechanics of the industry. The faculty are accessible, intellectually generous, and genuinely invested in students’ development. I found my research vision here, and I deeply appreciate the concentration’s role in this. The Evidence of Success series highlights UC Law SF students as they share how the College’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.
Take-Two Interactive lays off head of AI months after backing generative tech
Take-Two Interactive has just had a huge internal shake-up by laying off the head of Artificial Intelligence alongside a number of employees.
LifeNet Health Wins "Best Randomized Controlled Trial" Award for Diabetic Foot Ulcer Study
/PRNewswire/ -- LifeNet Health, a global leader in regenerative medicine, has received the Best Randomized Controlled Trial Award at the 2026 CAMPs Awards for...
Expanse: Osiris Reborn Dev Defends Using Gen AI For The RPG
Owlcat Games confirmed that their upcoming Mass Effect-like RPG is being developed with some help from generative AI
Ohio State star Caleb Downs addresses controversial injury rumors
Caleb Downs shot down a recent report that he had a degenerative knee condition.
OpenAI discontinues its Sora app amid robotics shift, compute limits
A spokesperson for OpenAI said the discontinuation of Sora comes as the company plans to focus on robotics rather than generative imagery.
Ravens were reportedly concerned about Maxx Crosby's degenerative knee issue for beyond 2026 season
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Crimson Desert admits it used generative AI for "early-stage iteration" and apologises AI images were not replaced before release
Crimson Desert developer Pearl Abyss has responded to claims its latest game used AI to generate images, admitting "2D …
Square Enix announces it will integrate Google’s generative AI Gemini into popular online game Dragon Quest X
Square Enix has found a use for Google’s generative AI Gemini and will be putting it to use in the popular online game, Dragon Quest X. Gemini will be used in-game as a feature that allows players to…
Baffling Crimson Desert Images Have Ignited A Generative AI Controversy
Did the developers mean to depict mushy-faced warriors atop many-limbed horses, or is generative AI simply back at it again?
Towards responsible AI for mental health and well-being: experts chart a way forward
On 29 January 2026, WHO‑supported experts met at a TU Delft workshop to address the rapid, largely untested use of generative AI for mental health support. Participants warned of risks to well‑being, especially for young people, and called for stronger governance.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Even developers were taken aback by Nvidia's DLSS 5 announcement
Could it change their attitudes to generative AI in gaming?
Why Generative AI Threatens Creative Roles In Media And Entertainment
Generative AI is bound to shrink the labor market for creatives, according to this task-technology fit analysis, by making them more efficient and by supplanting them.
Alexa+ launches in the UK, the first country in Europe to get Amazon's next-generation AI assistant
Powered by generative AI, the smarter, more conversational Alexa can complete tasks from start to finish—and is genuinely British.
Forum on harnessing Artificial Intelligence for health equity
Register to this forumOver the past decade, artificial intelligence (AI) has significantly evolved in complexity, performance, and utility. Its integration across a wide range of industrial sectors has accelerated, with healthcare emerging as one of the most transformative sectors. In this sector, AI has enabled high-impact applications – from enhancing the speed and accuracy of disease diagnosis and supporting clinical decision-making, to strengthening public health initiatives such as disease surveillance and workforce optimization. Moreover, AI holds immense potential to empower individuals, enabling them to take greater control of their personal health and well-being. Yet the central question remains: Who benefits, who is at risk, and do these innovations close or widen health inequities? While the potential of AI-enabled applications is substantial, many countries have approached their adoption with caution. This hesitancy stems from concerns about risks and benefits, including model bias, data breaches, privacy violations, and the erosion of professional skills due to over-reliance on AI. Additional barriers include inadequate data infrastructure and a lack of robust evidence on the most effective forms and interfaces of AI to enhance service delivery and system performance. Moreover, the rapid rise of Generative AI has introduced a heightened urgency for the development of comprehensive governance and ethical frameworks. The Asian Development Bank (ADB) Health Practice Team and Digital Sector, in collaboration with the World Health Organization (WHO) Regional Office for the Western Pacific, are convening the Forum on Harnessing AI for Health Equity on 25–26 March at ADB Headquarters. Senior health officials from 16 developing member countries (DMCs), alongside leading researchers, innovators, and policymakers from across Asia and the Pacific, will engage in discussions on how AI can be governed, financed, and scaled to deliver healthier lives for all. The forum is funded through the High-Level Technology Fund with support from the Government of Japan. Objectives The two-day forum aims to:Identify high-impact, evidence-based health AI use cases suitable for resource-constrained settings and map out a pipeline for potential supportIntroduce and validate the WHO's policy guidance on minimum necessary ecosystem for countries and institutions to self-assess readiness for AI adoptionObtain initial commitment from participating stakeholders to join a pilot regional initiative focused on data/model sharing for a priority health challengeEndorse a prioritized set of actionable policy recommendations focusing on governance, regulation, and sustainable financing necessary to scale high-impact health AI use cases in resource-constrained settings Target participants The forum will convene participants from 16 ADB DMCs including Bangladesh, Bhutan, Cambodia, Cook Islands, Fiji, Indonesia, Lao People's Democratic Republic, Mongolia, Nepal, Palau, Papua New Guinea, Philippines, Sri Lanka, Thailand, Uzbekistan, and Viet Nam. In addition, health system leaders and practitioners, private sector technologists, academic experts, representatives from civil society organizations, development partners, and philanthropic institutions engaged in AI for Health from Australia, the People’s Republic of China, Japan, Malaysia, New Zealand, Singapore, and the Republic of Korea will also be invited. SessionsDay 1 (25 March)Session 1: AI Use Cases for the Care Continuum: Improving Access and QualitySession 2: Adopting a risk-based approach for AI use case prioritizationSession 3: Establishing the Minimum Ecosystem for Implementation Risk ManagementSession 4: Future-Ready Health Workforce: Building Competency for Human-AI CollaborationDay 2 (26 March)Session 5: The Political Economy of AI in Health: Understanding Stakeholder Interests and their Impact on EquitySession 6: AI and Health Financing: Supporting Fair Coverage and ProtectionSession 7: AI Regulation and Oversight: Pathways for Different RealitiesSession 8: The Way Forward – Building Alliances and Regional Partnership How to registerThe forum will be held in a hybrid format. In-person attendance is by invitation only, while livestreaming of the forum will be available to the public. To register, please complete this form on or before 24 March 2026.Event organizers / partnersAsian Development Bank (ADB)WHO Regional Office for the Western Pacific High-Level Technology Fund (HLTF)ContactAkihito WatabeHealth Specialist, SD3-HSDawatabe@adb.org Jae Kyoun KimHealth Specialist, SD3-HSDjkkim@adb.org
Nvidia CEO says disgusted gamers are wrong about its controversial AI tech
Amid a litany of memes and disses, CEO Jensen Huang tries to correct the public about Nvidia's DLSS 5 by clarifying what kind of generative AI it is.
Gamers react with overwhelming disgust to DLSS 5's generative AI glow-ups
Nvidia's next frame-gen tech goes way beyond upscaling, and not in a good way...
DLSS 5 looks like a real-time generative AI filter for video games
Photoreal or Instagram filter-real?
Science Notes: Generative AI and Its Impacts | Rockefeller Institute of Government
Generative AI is now embedded in everyday tools. Science Notes looks at the urgent questions about bias, ownership, misuse, and environmental impact.
Healthcare Uses Specialized Language. It Needs Specialized AI, Too.
The potential generative AI in healthcare is enormous. They can generate patient education materials or clinical notes in seconds, flag incomplete documentation to keep care on track, or even suggest differential diagnoses . But when generalist models encounter the specialized “dialects” used across medical fields, they can miss critical clinical meaning—even when they read every word correctly. The result can be flawed decisions and eroding clinician trust. Healthcare organizations should treat AI like a supervised trainee: adapt models to clinical specialties, require transparent reasoning, and calibrate automation with human oversight.
Validating Generative AI-Based Social Science
On Feb. 20, the Center for Human-Computer Interaction + Design convened an interdisciplinary group to discuss the validity and trustworthiness of social and behavioral data simulated by large language models.
Choreographing molecular design with TANGO
Nature Computational Science - A reward function (TANGO) is developed to enforce building blocks in generative artificial intelligence and leverage the synthesizability of high-value materials.
Call for Proposals: Teaching Political Science in an Age of Generative Artificial Intelligence (GAI) | Deadline: April 5, 2026 -
The American Political Science Association’s (APSA) Teaching and Learning program and the Political Studies Association (PSA) Teaching & Learning Network are pleased to announce a call for proposals for a small cohort of political science/politics instructors to participate in a virtual teaching and learning symposium that will meet on Zoom between June 22-26, 2026.
Call for Proposals: Teaching Political Science in an Age of Generative Artificial Intelligence (GAI) | Deadline: April 5, 2026 -
The American Political Science Association’s (APSA) Teaching and Learning program and the Political Studies Association (PSA) Teaching & Learning Network are pleased to announce a call for proposals for a small cohort of political science/politics instructors to participate in a virtual teaching and learning symposium that will meet on Zoom between June 22-26, 2026.
Conexeu Sciences Appoints Jean-Romain (JR) Falconnet as Head of Business Development & Licensing
Reno, Nevada--(Newsfile Corp. - March 2, 2026) - Conexeu Sciences Inc. ("Conexeu" or the "Company"), a biotechnology innovator redefining regenerative medicine through a next-generation extracellular matrix platform, is pleased to announce Jean-Romain (JR) Falconnet as Head of Business Development & Licensing.In his role at Conexeu, JR will lead business development, licensing strategy, and strategic partnerships—supporting the company's growth roadmap and expanding opportunities to bring...
Experts to examine the use of generative AI in science
The Assessing and Imagining the Impact of Generative AI on Science Symposium, March 3-5, will feature experts from across academia and industry engaging in discussions on the use and implications of generative AI.
Eric Dane Says ALS Symptoms Started Months Before Diagnosis. What He Shared About His Disease
The actor died at 53 years old after a public battle with the neurodegenerative disease, which has no cure.
UT Health San Antonio researcher earns grant to study how the brain’s immune cells might actually contribute to Alzheimer’s - UT Health San Antonio
Cure Alzheimer’s Fund award aimed at better understanding microglia’s role Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu SAN ANTONIO, Feb. 20, 2026 – A researcher with the Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases at UT Health San Antonio has received a two-year, $402,500 grant award from the Cure Alzheimer’s Fund to study how microglia, […]
How CVS Health test-drives better care experiences using generative agents
CVS Health uses generative agent simulations to test customer experiences, uncover behavioral insights, and design better care journeys before real patients feel the impact.
What Rev. Jesse Jackson's Family Shared About His Illness and Other Health Challenges Before His Death
The civil rights activist had been battling PSP, a rare neurodegenerative condition, for over a decade before his death.
Unity boss claims engine's next generative AI update will let users prompt "full casual games" into existence, just by using natural language
Unity CEO Matthew Bromberg has touted generative AI advances to its game engine that'll soon enable users to "prompt fu…
Generative AI Revolutionizes the Life Sciences Industry Accelerating Drug Discovery, Cutting Costs, and Enhancing Innovation
According to data published by Precedence Research, Generative AI is transforming the life science sector, driving innovation in drug discovery, clinical trials, and manufacturing, while reducing costs and improving efficiency. With investments in AI, companies are reshaping R&D and achieving faster, smarter, and more personalized healthcare solutions.Ottawa, Feb. 16, 2026 (GLOBE NEWSWIRE) -- As Generative AI moves beyond pilot projects to become a foundational tool in the life sciences, it acce
Accidental discovery hints at mystery structures within our brain
Scientists may have stumbled across a network of vessels in the brain that helps clear out waste fluid – a discovery that could "represent a paradigm shift in our understanding of all neurodegenerative diseases"
The Real Truth About The Upsides And Downsides Of Generative AI As A Mental Health Advisor
Most discussions about AI that's used for mental health is tilted to one side or the other, either its good or its bad. The full story is a tradeoff. An AI Insider scoop.
Gillibrand urges FTC to examine impacts of AI on older Americans
The junior New York senator requested a briefing on the FTC’s inquiry into generative AI companions.
Dee Snider resigns from "Twisted Sister" citing health issues, band cancels reunion shows
Lead singer and frontman Dee Snider said he suffers from degenerative arthritis and has had several surgeries over the years.
Using generative AI to help scientists synthesize complex materials
Generative AI models have been used to create enormous libraries of theoretical materials that could help solve all kinds of problems. Now, scientists just have to figure out how to make them. In many ...
How generative AI can help scientists synthesize complex materials
DiffSyn, a computer model developed by MIT researchers, suggests promising ways to synthesize new materials for faster experimentation.
DiffSyn: a generative diffusion approach to materials synthesis planning
Nature Computational Science - A generative AI approach is developed for predicting materials synthesis recipes—a complex challenge in materials science. Using this approach, the authors...
"Built On Theft And Plagiarism" - A Growing Number Of Game Developers Are Sick To Death Of Generative AI
"I'd rather quit the industry than use Generative AI"
Google’s New Chrome ‘Auto Browse’ Agent Attempts to Roam the Web Without You
Google’s latest addition to its Chrome browser puts generative AI behind the wheel and you in the passenger seat.
Science Slam in Cologne: When researchers steal the show
As a PhD candidate at University Hospital Cologne, Verena Dzialas researches neurogenerative diseases like Alzheimer’s. On stage at Science Slam events, she explains complex brain processes in accessible ways.
We must not let AI ‘pull the doctor out of the visit’ for low-income patients
Generative AI is being pushed into healthcare – and diagnostic risks may deepen the class divide
Google Photos can now turn you into a meme
Me Meme uses generative AI to combine a reference photo with templates.
Apple to Revamp Siri as a Built-In iPhone, Mac Chatbot to Fend Off OpenAI
Apple Inc. plans to revamp Siri later this year by turning the digital assistant into the company’s first artificial intelligence chatbot, thrusting the iPhone maker into a generative AI race dominated by OpenAI and Google.
'Art May Still Be Created With the Same Tools That Created the Slop' — Razer CEO Believes Gamers Will Eventually Come Around on Generative AI Use in Development
Razer CEO Min-Liang Tan has weighed in on the discussion surrounding generative AI in game development, claiming that the controversial technology has a place in the industry, but gamers just aren’t aware of the art it will produce yet.
How to Colorize and Restore Old Photos With Generative AI
Put your precious memories back in the spotlight.
Games Workshop Rejects the Abominable Intelligence
The makers of 'Warhammer' declare heresy on generative AI, banning its use in the company's design process.
Larian will not use generative AI for Divinity concept art
"That way, there can be no discussion about the origin of the art"
Manor Lords publisher Hooded Horse won't work with studios using generative AI
CEO Tim Bender has described the technology as "cancerous"
Amazon Stock Gains As It Launches Alexa Website To Compete With ChatGPT, Gemini
Amazon stock gained as the tech giant launched a stand-alone web app for its generative AI Alexa+ assistant.
The most important PC gaming news stories in 2026
Thoughts on the year of gaming to come, and in particular, GTA 6, unions, Saudi Arabia, generative AI and sex.
AI Labor Is Boring. AI Lust Is Big Business
After years of hype about generative AI increasing productivity and making lives easier, 2025 was the year erotic chatbots defined AI’s narrative.
LG Gram Pro AI laptops to debut with Exaone 3.5 and long battery life at CES
LG Electronics has revealed it will bring new ultra-light LG Gram laptops to CES 2026. The devices will feature the proprietary Exaone generative AI model and extended battery performance.
Level-5 CEO Wants People To Stop Demonizing Generative AI
Level-5 CEO Akihiro Hino has shared further thoughts on AI after a past interview of his went viral online
Hollywood cozied up to AI in 2025 and had nothing good to show for it
Hollywood bet big on generative AI slop in 2025.
Woman Suffers AI Psychosis After Obsessively Generating AI Images of Herself
A woman working for a generative AI image startup says the tech led her into a manic bipolar episode, which triggered psychosis.
Battlefield 6 players suspect AI cosmetics have been snuck into the game, despite EA saying that wouldn't happen
Battlefield 6 players have found what they believe to be an generative AI sticker in the game, causing outrage.
ChatGPT recapped your personal AI habits in 2025. Here's how to see yours.
Reflect on your generative AI use this year.
Indie Game Awards retracts Expedition 33 prizes due to generative AI
The game lost its Game of the Year and Debut Game awards.
The Indie Game Awards snatches back two trophies from Clair Obscur over its use of generative AI
The Indie Game Awards has stripped Clair Obscur: Expedition 33 of two awards over its use of generative AI. The awards ceremony doesn't allow the use of generative AI in any capacity.
A new drug could stop Alzheimer’s before memory loss begins
New research suggests Alzheimer’s may start far earlier than previously thought, driven by a hidden toxic protein in the brain. Scientists found that an experimental drug, NU-9, blocks this early damage in mice and reduces inflammation linked to disease progression. The treatment was given before symptoms appeared, targeting the disease at its earliest stage. Researchers say this approach could reshape how Alzheimer’s is prevented and treated.
Sports brands and AI: A winning combination
Millions of sports fans are being brought ever closer to the live action from their home screens through the power of agentic and generative AI.
'Clair Obscur: Expedition 33' stripped of Indie Game Awards due to generative AI use
It had previously been announced Game of the Year.
GOTY Winner Clair Obscur Disqualified From Awards Show
One of the most critically adored games of 2025 has just been disqualified from an awards show due to its use of generative AI.
Indie Game Awards disqualify Clair Obscur: Expedition 33 after generative AI controversy
According to a statement issued by the Indie Game Awards, Clair Obscur: Expedition 33 has been stripped of both awards it won. This decision came after producer François Meurisse confirmed the use of generative AI in the game’s development.
Larian announce plans to let folks ask anything about their generative AI use, asserting "a lot has become lost in translation"
Larian CEO Swen Vincke has announced the studio's plans host an ask me anything session about their generative AI use and Divinity's development process.
Backlash over Larian CEO's AI comments is a leadership problem
CEO Swen Vincke angered developers with his description of how Larian Studios is using generative AI. There's good reason for it.
The top 10 game industry trends of 2025
Generative AI, reshaping company structures, and far-right bigotry are among the most defining trends of 2025.
Survey: AI’s role in business ideation is growing
Generative AI is beginning to reshape not just business operations but the way companies think, according to a new analysis in the Harvard Business Review. While many executives focus on efficiency and cost reduction, the authors argue that the technology’s greater promise lies in the ideation phase—the early stage of innovation where assumptions are challenged […]
GenAI users Larian forced to build Divinity around RAM shortage caused by GenAI
Larian's new Divinity game is having to be made with the current RAM storage in mind - a shortage caused by generative AI tools like the ones Larian employ.
Larian Responds to Generative AI Backlash: Divinity Have Any AI Parts
"Holy f*ck guys we’re not 'pushing hard' for or replacing concept artists with AI."
Larian CEO Responds to Divinity Gen AI Backlash: 'We Are Neither Releasing a Game With Any AI Components, Nor Are We Looking at Trimming Down Teams to Replace Them With AI'
This morning, the news broke that Larian Studios, developer of Baldur's Gate 3 and the upcoming, just-announced Divinity, is apparently using generative AI behind the scenes. The backlash has been swift, and now Larian founder and game director Swen Vincke is responding to clarify his remarks.
Larian want to complete Divinity in "three to four years", and they're making limited use of generative AI
Larian are hoping to get their latest Divinity RPG out a lot faster than Baldur's Gate 3, care of a larger development team.
Larian is using generative AI, confirms CEO, but Divinity won't contain anything AI-generated
Larian is using generative AI as part of its game development process, but the studio's new Divinity game won't include anything AI-generated.
Amazon's Official 'Fallout' Season 1 Recap Is AI Garbage Filled With Mistakes
Prime Video's latest needle-poke into generative AI's bubble comes on the heels of its anime dubbing debacle.
Judge orders Google to rebid for default search deals every year in a major antitrust blow
A federal judge orders Google to limit default search deals to one year, in an antitrust effort to open doors for rivals in search and generative AI.
New 'Postal' Game Canceled One Day After Reveal, Following Generative AI Allegations
Postal: Bullet Paradise has been scrapped and the developer is shutting down after gamers claimed the trailer used generative AI assets.
Developer of New Postal Game Shuts Down Studio After Game Was Announced, Then Canceled Over Gen AI Allegations
The studio behind the Postal franchise just announced that it will be publishing a brand new Postal game, to be developed by Goonswarm Games. Unfortunately, it even more recently announced it would be cancelling said game, due to accusations that Goonswarm had used generative AI in its development.
"Has caused extreme damage to our brand and our company reputation" - Running with Scissors cancels Postal: Bullet Paradise over AI-generated assets... two days after reveal
After receiving pushback for its flagrant use of generative AI, Postal: Bullet Paradise has been cancelled… just two days after being revealed.