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Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)
Earnings To Watch: Elevance Health (ELV) Reports Q3 Results Tomorrow
Health insurance provider Elevance Health (NYSE:ELV) will be reporting results this Wednesday before market hours. Here’s what investors should know.
Mario Nawfal (@MarioNawfal) on X
WTF India?!?! Your entertainment industry needs a revamp Writer: Ian
Low Testosterone Opens the Door to a Broader Health Conversation
Low testosterone can signal broader health concerns involving weight, metabolic health, sleep and lifestyle. Cleveland Clinic’s Mark Paulos, MD, explains why comprehensive evaluation and a whole-person treatment approach matter.
Oracle and AstraZeneca Partner to Advance AI-enabled Healthcare Innovation
Oracle today announced an agreement with AstraZeneca to explore how AI and real-world data can help clinicians identify eligible patients for clinical trials, accelerate evidence generation, and bring relevant research insights into everyday care. The collaboration is expected to combine AstraZeneca's scientific and therapeutic expertise with Oracle's health data, cloud, AI, analytics, and clinical workflow capabilities.
Dan Lanning addresses Evan Stewart arrest, punishment
Oregon Ducks football coach Dan Lanning addressed the arrest of WR Evan Stewart on Monday night during his weekly press conference.
Things to do: These are the best entertainment events in Brevard for Oct. 16-22
Find your weekend adventure! Film festival, Oktoberfest and Reggae top our list of Brevard's best entertainment events.
Former Las Vegas Councilwoman denies misusing donations during judicial discipline hearing
Michele Fiore testified that she believed a developer paid for a memorial statue honoring slain Metro officer Alyn Beck as she denied misusing donations during a Nevada judicial discipline hearing.
SnakePit Post-season GDT, #17
Two ways tonight can go. We either see a Rays victory, and they move on to the World Series, starting on Friday in Milwaukee. We spend the next three days staring out the window, twiddling our thumbs and waiting for that to start. Or the Guardians prevail, and we look forward to a winner-take-all battle […]
Toppenish School District receives $7.5 million federal grant to expand mental health services for students
The BriefThe Toppenish School District has been awarded up to $7.5 million through Project AWARE (Advancing Wellness and Resiliency in Education), a federal grant administered by the Substance Abuse and Mental Health Services Administration (SAMHSA).The grant will provide up to $1.5 million annually over five years to expand mental health services, strengthen substance use prevention and intervention, and improve access to support for students.District officials say the funding will help address identified gaps in services, particularly drug and alcohol counseling at the high school level, and will allow the district to build capacity for long-term mental health support.TOPPENISH, WASHINGTON — The Toppenish School District has been awarded up to $7.5 million through Project AWARE (Advancing Wellness and Resiliency in Education), a federal grant administered by the Substance Abuse and Mental Health Services Administration (SAMHSA), to expand mental health services and substance use prevention for students.District officials said access to mental health resources has been limited, making it difficult for some students and families to get the support they need. The federal Project AWARE grant will help address those challenges by bringing schools and local healthcare providers together to better support students.The grant will provide up to $1.5 million annually over five years to expand mental health services, strengthen substance use prevention and intervention, and improve access to support for Toppenish students. Deputy Superintendent Dr. Jeff Camero said the district is focused on coordinating with service providers in the area to work as a unified team."We made the awareness with the grant. But looking at all the service providers in the area and how can we all together work as a team?" Camero said.Camero said the district wants to use those resources to reach students earlier and provide more support for those struggling with their mental health. The district plans to address a range of mental health challenges, from anxiety and depression to youth suicide risk. Camero emphasized the importance of supporting students in grades eight through twelve, where suicide rates are a particular concern."Making sure from anxiety to depression, making sure that we can help support our students at those levels, but also the youth suicide risk, looking at that as a top in this area, in our grades, you know, eight, for example, eight through 12, looking at suicide rate and looking at how whether we look at the ACES or whatever program we're looking at, that's federal, how that connects and how we can better serve our students with this extra funding," Camero said.The funding will allow the district to bring in additional staff, including mental health and substance use specialists, to work directly with students and connect families with community resources. The district is already posting positions, including a director role, with additional positions expected to follow.District officials are also thinking beyond the grant's five-year timeline. Brittany Kaple, Director of Public Relations for the Toppenish School District, said the intent is to build capacity and establish connections that will sustain mental health services even after the grant funding ends."We do have the director position already posted, with some of our other positions following really close behind that. But the intent is to, you know, it's a five-year grant, so those positions would be funded for that five years. But there's also the intent to build capacity and make those connections so that at the end of the grant, when that money, you know, if that money is not renewed," Kaple said.As student mental health needs continue to evolve, access to drug and alcohol counseling has become an important priority for the district. Kaple said teachers and staff have been raising concerns about the need for more support, especially at the high school level."And that was something that was also an identified need by our high school staff when the superintendent met with them last school year. They said that that was a really great need, something that they felt was a gap in services that we were providing for our students. And so this is going to be one way to help support that need," Kaple said.The Toppenish School District says its goal is to ensure students and families have access to the support they need, both now and in the years ahead. Additional positions, including drug and alcohol counselors and family engagement specialists, are expected to be posted in the coming weeks. News Sunnyside City Council navigates 2027 budget planning Monique Garcia News "Dancing with the Stars" champion J.R. Martinez shares message of resilience during Central Washington visit Tyler Wargo News Toppenish, Mattawa educators honored at state Educator of the Year Awards Erin Wencl News Kennewick educator named 2027 Washington Teacher of the Year Erin Wencl News Voters to decide the next Yakima County Sheriff Monique Garcia COPYRIGHT 2026 BY APPLE VALLEY NEWS NOW. ALL RIGHTS RESERVED. THIS MATERIAL MAY NOT BE PUBLISHED, BROADCAST, REWRITTEN OR REDISTRIBUTED.
Fruit and sugary drinks stood out in a three-year study of teenage mental health
A three-year study of 6,537 Australian adolescents found that higher fruit consumption was associated with a lower risk of elevated depression and anxiety symptoms, while greater sugar-sweetened beverage intake was associated with increased risk. Vegetable consumption showed no significant association with either outcome, and the observational findings cannot establish cause and effect.
Blues Defenseman Gets Encouraging Injury Update
Logan Mailloux underwent right-hand surgery at the end of September after a preseason game against the Chicago Blackhawks. The St. Louis Blues defenseman fought Cole Smith in the first period of the Blues’ final preseason game. Mailloux was set to be reevaluated in eight weeks after the surgery. That would put his potential return date […] The post Blues Defenseman Gets Encouraging Injury Update appeared first on HEAVY.
Commanders vs. 49ers live updates, inactives, where to watch: Mike Evans, Stefon Diggs active for Monday Night Football
Echo Lake Entertainment Promotes Dana Jackson & Matt Horwitz To Partner
EXCLUSIVE: Dana Jackson and Matt Horwitz, a pair of longtime literary managers at Echo Lake Entertainment, have been elevated to partners in their division. Acknowledging “the extraordinary creativity...
Rams Get Devastating Injury News on Multiple Stars
The Los Angeles Rams suffered three long-term injuries to key position player groups during their loss to the Arizona Cardinals on Sunday. The post Rams Get Devastating Injury News on Multiple Stars appeared first on LA Sports Report.
Raiders cut OL Evan Neal from the practice squad
The Raiders cut offensive lineman Evan Neal from their practice squad on Monday, the team announced.
‘Over $25,000’ in damage: Bellevue honey business devastated by historic flooding
In Bellevue, September's floodwaters washed away 35 beehives — and with them, years of work
Nevada DMV extending business hours during election period
The Nevada DMV says it will be expanding business hours and walk-in services during the election period.
Nevada DMV extending business hours during election period
The Nevada DMV says it will be expanding business hours and walk-in services during the election period.
Moonlighter dev delays Steam playtest for its "Tower Defensevania" ReVamp over concerns that AI copycats might clone it before launch
Digital Sun has delayed a planned Steam playtest for ReVamp due to "games being reverse-engineered, cloned and published before the original."
11th-century 'pizza peel' discovered in Russia doubled as a medieval game board
Archaeologists in Russia unearthed a flat wooden "pizza paddle" that had a board game carved into it.
AI Cloning Threatens To End Public Playtests For Video Games
Moonlighter dev Digital Sun has cancelled plans for a public playtest of its next game, for fears of Claude clones
Morning Download: Nevada-San Jose State football game to air live on NSN
On weekday mornings, Nevada Sports Net will recap three big headlines of the day in its Morning Download. Read below for today's topics.
Dolphin Entertainment to Present at the 20th Annual LD Micro Main Event
PT on October 20 and Participate in One-on-One Meetings with InvestorsMIAMI, FL / ACCESS Newswire / October 19, 2026 / , Inc. (NASDAQ:DLPN), a leading entertainment marketing and content production company, today announced that Bill O'Dowd, Chairman and CEO, will be presenting at the LD Micro Main Event being held October 19-21, 2026 at the Luxe Sunset Boulevard Hotel in Los Angeles.
VOTE: What is your biggest fall health question?
News4 NBC Reno covers news, sports, weather and traffic for the Reno, Nevada area including Sparks, Carson City, Virginia City, Silver City, Stagecoach, Silver Springs, Sun Valley, Cold Springs, Spanish Springs and Fenley, Nevada and Truckee and Tahoe City, California.
Election stakes are high for Colorado’s farming future
U.S. Rep. Gabe Evans is running to defend his seat against Manny Rutinel. I don’t know either of the two, but I was able to visit with Evans for half an hour earlier this week and while we aren’t aligned on everything, we have similar feelings about dear Manny. Evans said he’s hearing the same […]
HMG Pop Up Paper Extends 3D Paper Engineering Into New Wholesale Stationery Lines
Hanoi manufacturer introduces pop-up business cards, affirmation cards and structural invitations while updating how it evaluates customer outco...
Addressing cascading mountain hazards requires scientific cooperation across borders
Editor's note: The devastating glacier collapse and ensuing debris flow near the China-Nepal border in August underscored the need for stronger cross-border cooperation in addressing mountain hazards. Against this backdrop, the Global Partnership for
HEALTH AND FITNESS: Steps to prevent breast cancer
Since this is Breast Cancer Awareness Month, many local and national organizations are promoting breast cancer awareness, sharing information about the disease, raising money to support research and celebrating survivors. This represents the most visible part of a year-round effort to educate about, screen for, and hopefully cure this devastating disease. Of course, these are all worthy goals that deserve our attention and support.
Health Innovation South West and Helfie AI announce partnership to evaluate digital-first hypertension screening
/PRNewswire/ -- Helfie AI and UK-based Health Innovation South West have announced a partnership to explore how digital-first approaches to hypertension...
AI recommended your brand. Did it get your business right?
Marketers must evaluate the accuracy, context and destination of AI recommendations rather than relying solely on visibility metrics.
Elevance Health: Why I Don't Believe In The Stock At This Price
Elevance Health faces structural headwinds, with rising medical costs outpacing reimbursement and government program pressures eroding margin stability. I rate ELV stock a Hold.
The sport of online harassment
Non-consensually posted intimate images can devastate women – and beget male bonding.The burner accounts on X loosely grouped into the “burnerverse” started by bonding over college sports – but soon took a darker turn when some of them began trying to make salacious rumors or non-consensual intimate images of young women and their names go viral. Ej Dickson investigated the burnerverse for Wired, profiling one of these women who were doxxed – and found links between these burner accounts and college fraternities. But what makes misogyny such a potent tool for men’s bonding? And with laws against non-consensually distributed intimate images in all 50 states – how is it still happening at scale?To talk more about the culture that supports this kind of harassment and the structures that keep it in place, Brittany is joined by Ej Dickson, senior culture writer at wired, and Dr. Mary Anne Franks, professor at the George Washington University Law School and president of the Cyber Civil Rights Initiative.Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.
St Vincent's Australia convenes first national AI Clinical Council
The council will guide the evaluation and adoption of AI technologies across its hospitals, aged care facilities and home-based services.
Nevada Health Centers will host mobile dental services at Carson City School District schools
They will be at Empire Elementary School on Monday from 1 p.m. to 6 p.m.
Ben Simmons receives devastating injury update amid comeback attempt
Simmons is believed to have torn his Achilles tendon on Sunday, ruling him out for the rest of the year.
Amanda Seyfried addresses evasive red carpet comments about Elizabeth Holmes: ‘What AM I even saying’
The actress, who portrayed Holmes in “The Dropout,” was hesitant to weigh in on Nathan Fielder’s new doc about the disgraced Theranos founder.
Streaming’s Biggest Show Returns…and a Buzzy Genre Struggles
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) Obviously, the big news of the week (if not month) is Netflix letting go of executive Bela Bajaria, their chief content officer. I’m going to cover this in my next “Most Important Story of the Week”, but I also have a data angle that I might publish before then. (Too much news this month, am I right?) But first, I have a bonus Streaming Ratings Report issue for you. Today’s article is a bit of a grab bag of topics I’ve wanted to write about, but couldn’t squeeze into the (already very long) Streaming Ratings Report issues. The NFL drives huge viewership numbers, so I’ve got a look at that. A whole bunch of TV shows returned to the traditional broadcast channels, and I have thoughts. And I have a quick look at adult animated shows, since a couple flopped earlier this month. Plus, the Emmys aired earlier this month, and we got some fun data bout how popular those nominated shows are and why I’m not optimistic about the show’s future. That’s a lot, so let’s dive right in. Subscribe Sports - Football Remains the King of Streaming Over the last two Streaming Ratings Reports, I sorta ignored the biggest “show” each week. (I was tempted to say “piece of content” but I know that word bugs folks.) In my database, I call these “specials”, and they sure are special. I speak of the king of American TV: football!!! Streaming football is back and, unlike some other sports, it routinely dominates all viewership. Probably the best way to show this is to update one of my favorite graphics, the “40 Million Hour Club”1 since football games have joined that club each week they’ve premiered: (Yep, that’s the data through 28-Sep, the first four weeks of the season. As a reminder, I take the average minute audience provided by Nielsen, factor out a percentage of linear TV viewers in home markets, and multiply the run time by the three-hour runtime.) Again, the numbers are huge. Let’s start with Netflix. They grabbed the rights to the bonus opening week NFL Kickoff game (which was on YouTube last year) and it put up 18.5 million viewers on average. That nets out to 47.4 million hours of estimated streaming hours. That’s good! Though, notably, it’s well below Christmas Day games from previous years. Compared to other streamers/broadcasters, that’s a bit of a mixed result. On one hand, Netflix’s 18.5 million average is about what YouTube claimed last year, though Nielsen used a bespoke methodology at that time, so I trust this viewership figure more. So that’s good. (The game also shifted from a Friday to a Thursday and that could have helped the viewership as well.) And Netflix continues to best Prime Video in total viewership—as you’ll see next—though Netflix has had much higher-profile (opening week and Christmas Day) games. NBC/Peacock’s opening game the night before averaged 25.1 million average viewers, which is just much bigger than Netflix (or Prime Video). That’s the big caveat to all streaming viewership records: even in success, they can’t compete with traditional linear TV. Previously, I called this my “hierarchy of viewership”, and the data keeps supporting that thesis. The downside for NBC is that this game’s viewership was down compared to previous years, though it may be a counting issue. Here’s a great chart from Sports Media Watch: Indeed, looking at all the opening week games across all windows, Netflix still lags the other primetime windows, but does well compared to the afternoon games: I saw a few folks make the case that streamers still lag traditional broadcasters in reach, and I’d add they really lag compared to “broadcast plus streaming” options like NBC/Peacock, ESPN/Disney+ and CBS/Paramount+. The best data I saw for this came from Samba TV, who charted reach through the 2025 season, and, wow. (Samba TV’s numbers are historically lower than Nielsen’s, so don’t compare their household figures to Nielsen’s hours, but use them as a proxy for the relative reach of the streamers.) The good news is Prime Video is NOT having a down year. Their opening Thursday Night Football game reached 18.6 million viewers (about what Netflix got), but that’s a high for Prime Video on Thursdays and the biggest Thursday night game since 2015. The TNF games the weeks of 21-Sep and 28-Sep continued this streak, getting 43.1 (16.8 million average viewers) and 42.5 total hours (16.6 million average viewers), which were both up from last year. Still, that continues the (typical) season slide: (For those new-to-streaming-football-numbers folks, the viewership declines for Thursday Night Football as the year goes along.) Overall, it appears as if Prime Video is now part of the “football habit”, be it for customers at home or out at places like bars and restaurants. And its viewership is slowly catching up to broadcast. One last chart shows this. Last season, Nielsen started adding out-of-home viewership to the charts, so I try not to do season-to-season comparisons as I did for the first few years. And while Nielsen added Big Data viewing this year, I’m going to compare the last two seasons. Here’s that chart, which shows the season-over-season gains: When it comes to streaming football, we have to keep a few seemingly contradictory thoughts in our head… First, streaming doesn’t come close to matching broadcast’s reach and, thus, viewership. Second, even with that gap, football is still the biggest “thing” on streaming. It’s very, very popular. Third, while some methodology changes have likely helped Prime Video’s numbers, their viewership does appear to be growing. Lastly, yeah, the NFL started the season off poorly, with week one dragging down the numbers in year-over-year comparisons. However—and again, methodology changes may have helped this—the viewership grew compared to previous seasons over the next couple of weeks. So football is still king. On streaming and off. Television - Adult Animation Continues to NOT Make the Streaming Charts In the last two reports, two adult-animated shows whiffed: Netflix’s animated comedy, Dang! Paramount+’s Sega-video-game-inspired fantasy/comedy, Golden Axe. Neither made the charts, but that’s usually the case for animated shows. I mean, here’s literally every animated show that’s made the Nielsen Original charts since the start of 2025: And one of those shows is G_abby’s Dollhouse_! A kids show! The problem with charts like this is that they don’t give you a sense of how many shows miss the charts. Netflix had at least eleven animated flops, including comedies like Big Mouth (a show everyone assumed was popular in the pre-Streaming Ratings Era), Long Story Short, Haunted Hotel, Mating Season, Strip Law, and Alley Cats, and action shows like Blood of Zeus, Castlevania: Nocturne, Devil May Cry, Splinter Cell: Deathwatch, and Tomb Raider: The Legend of Lara Croft. Prime Video had at least six animated misses, two in the same universe (Hazbin Hotel, Helluva Boss), three more comedies (#1 Happy Family USA, The Second Best Hospital in the Galaxy and Kevin) and an action show (The Mighty Nein). Disney+ had MCU and Star Wars animated misses (Eyes of Wakanda, Marvel Zombies, Star Wars: Visions, Star Wars: Maul – Shadow Lord, and Star Wars: Tales of the Underworld) but I can’t tell how many of those shows were geared towards adults. HBO Max had Harley Quinn and Hulu had Solar Opposites. None of these shows made the charts! That’s a lot of misses! If I remade the chart with all those misses, here’s how it would look: Listen, I know the counter arguments. First, it’s cheaper to produce animated shows than live action. Fair enough, but with viewership this low, even that cheaper price point starts to not matter. Second, just look at the acquired charts. Hit animated comedies can generate viewership for years! Shows like The Simpsons, South Park, Family Guy, and Bob’s Burgers do really, really well. Fair enough, but streaming has failed to recreate the dynamic that Fox has mastered so well. That’s a problem for streaming still. Television - Emmys! The annual Emmys broadcast was a few weeks ago, and I’ve got data on how the nominees performed on streaming, plus hot takes on this year’s viewership (and the big news about the broadcast’s, er, streamcast’s future). We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… The top Emmy-nominated shows… ...why I’m worried about the future of the Emmys telecast... ...the pros of broadcast television ...and the cons... ...please subscribe! We can only keep doing this great work with your support. Coming Soon! Next week, we’ve got a double issue (since the weeks of 21-Sep and 28-Sep were so light), but then I’ll be all caught up after a deluge of streaming ratings data from Nielsen in September. In the meantime, I’m going to try to take a look at Netflix’s stats to explain why Bela Bajaria is out. But even light weeks give me plenty to talk about. The Great British Baking Show returns to Netflix and Apple TV has a buzzy new star-studded comedy. And Netflix has a controversial-but-appears-to-be-popular new game show. Plus big films like Toy Story 5, Backrooms and The Breadwinner head to streaming. And is East of Eden a hit? After that, The Kardashians return to Hulu, Prime Video has a reboot of Carrie, and Netflix has a horror show, Below. Disclosure Day heads to Peacock, The Housemaid heads to HBO Max_,_ a new Ben Affleck film, Animals, lands on Netflix, and Apple TV has a new John Cena action film based on, checks notes, Hasbro’s Matchbox toys. Okay. Longterm, some interesting TV production news. HBO Max ordered How to Survive Without Me, starring Kaley Cuoco, Joshua Jackson, Ray Romano and Rita Wilson, for fifteen episodes! I love that some streamers (or, at least, HBO Max) are finally ordering TV shows with more than eight episodes. In less wise production news, Landman does not appear to be coming back this year, since it just started production. Frankly, I don’t love this (get your shows out on time) but Landman is so popular, I doubt it matters.
Castlevania Belmont's Curse: Catacombs of Paris walkthrough (Part 3)
Rose descends into the dark Catacombs of Paris and faces Death in Part 3 of our Castlevania: Belmont's Curse walkthrough.
Woman allegedly hit business owner with a closed fist when he tried to stop robbery
News4 NBC Reno covers news, sports, weather and traffic for the Reno, Nevada area including Sparks, Carson City, Virginia City, Silver City, Stagecoach, Silver Springs, Sun Valley, Cold Springs, Spanish Springs and Fenley, Nevada and Truckee and Tahoe City, California.
Scientists discover a surprising twist in Japan's 7,300-year-old volcanic apocalypse
A catastrophic volcanic eruption 7,300 years ago devastated Japan, but new research reveals that its impact on prehistoric populations was far more complex than previously believed. While some communities disappeared or declined, others unexpectedly flourished as survivors migrated, adapted, and found new ways to thrive.
Oklahoma voters, your family's politics don't have to be yours
Family political traditions are meaningful, but you should evaluate your own needs before casting your ballot.
My dad's death showed me that experiences matter more than money
When my dad died, I reevaluated how I approach work. I'm honoring him by living a more full life, and valuing experiences over money.
'He's everywhere': Carl DeMaio's push to make the GOP relevant again
Assemblymember Carl DeMaio, a conservative from San Diego County, has become a prominent voice for state Republicans. His vehicle this election is Proposition 39, the voter ID measure.
Iran Warns of More Devastating Response to Any US-Israeli Aggression
TEHRAN (Tasnim) – Secretary of Iran’s Supreme National Security Council Mohsen Rezaei warned that Iran’s Armed Forces have prepared a more devastating plan for any new military adventure than their response during the previous 12-day and 40-day US-Israeli wars of aggression.
Play science games, win science prizes
The 2026 winners for the Nobel Prize in the sciences, explained
Oregon’s top wide receiver out vs. Nebraska
Evan Stewart is set to miss the matchup with the Cornhuskers, joining teammate Jeremiah McClellan on the injury report.
The American Forest, Maybe Not-So-Primeval
New Yorker explores how Indigenous peoples changed the landscape before colonists
One shot while shopping at Dearborn business
Just after 6 p.m. Saturday a fight broke out at a business in the area of Ford Road and Oakman Boulevard, that resulted in one person being shot.
Benefit supports historic Versailles business months after fire
Community members gathered at a benefit car show on Oct. 17 to support the Wilson family as they plan to rebuild Wilson’s Pool Room following a devastating fire.
‘No Kings Vote Early’ rally in Fall River draws a crowd
About 60 protesters against the Trump administration lined both sides of William S. Canning Boulevard, bundled up against cold winds.
Addressing mental health proactively for our loved ones
As suicide and mental health concerns continue to impact families and communities, an Atlanta-based mindset expert, Michelle Bryant Johnson, shares how to recognize warning signs, support someone in crisis and navigate grief after devastating loss. You can learn more about SPARK at https://www.michellebryantjohnson.com/spark1000
Knicks’ Season Opener: 3 Things To Watch Against 76ers
In the New York Knicks' season opener, the team will begin their quest to defend the NBA title. There will be no easing into things over the Knicks' first 10 games. In particular, when they welcome the Philadelphia 76ers to Madison Square Garden on Tuesday, Oct. 20, they'll be facing a revamped opponent with plenty …
Steam's achievements rework looks great
PC gaming platform Steam has responded to Xbox's recent Mythic achievement rework with a revamp of its own, and it has some ideas Xbox might want to consider.
US Army will detonate unstable explosives near ammo plant
The controlled detonation of the toxic degraded material will occur in the coming weeks, with temporary evacuations planned for residents.
Sunbelievable tanning, wellness business opens in Raritan
Sunbelievable has opened at Raritan Crossing in Raritan, bringing tanning, wellness services and retail products to the shopping center.
Anthony Tyus III will be elevated in Week 6
Carolina Panthers RB Anthony Tyus III will be elevated for matchup with Philadelphia
Manny Rutinel smashes Colorado House race fundraising record in 8th CD
Democratic congressional candidate Manny Rutinel raised more than $4.2 million in the most recent quarter in his bid to unseat Republican U.S. Rep. Gabe Evans in Colorado’s most competitive U.S. House race, hauling in more than twice as much as Evans and setting a new state record. Across the board, the state’s Democratic nominees outraised […]
Man accused in chainsaw killings ordered into emergency mental health treatment, court documents say
Court records show the order was filed Friday, October 16. It says 47-year-old Thomas Steele’s mental condition has “deteriorated” since a judge first ordered a competency evaluation Tuesday, October 13.
‘There Should be a Game Award for Hot Dads’ — Castlevania: Belmont’s Curse Devs Are Fully Aware and Loving the ‘Horny’ Fanart for Their Game
The developers behind Castlevania: Belmont’s Curse are enthusiastic about the “horny” fanart they’ve seen of the game’s characters, saying they specifically made them "hot" to appeal to fans.
Collin Gosselin slams mom Kate for mental health claims, says ‘maybe it’s time’ she get psychiatric evaluation
Collin Gosselin and his mother, Kate Gosselin, have been locked in a bitter feud after he accused her of abuse in his memoir, ‘In the Shadow of Eight,’ which released on Oct. 13.
Evaluating Brian Cashman’s 2026 season
The Yankees’ head of baseball had some hits and many misses this year.
Castlevania's Most Iconic Song Should Chain Whip Me To Death, Not Put Me In A Thousand Year Sleep
The Belmont's Curse version of "Bloody Tars" is more restrained than it should be
What we know about Billy Evans, Elizabeth Holmes' long-term partner
Elizabeth Holmes, her partner Billy Evans and their two children are the focus of the new, nearly three-hour long documentary, "You Can See Everything."
Business temporarily evacuated after gas leak in Horry County
A business was temporarily evacuated after a gas leak in Horry County on Friday.
Important Players to Watch: College Football Week 5
The season is progressing but Jesse Legree and Jeremiah Smith are elevating every week along with others
NC Life Sciences News: Labcorp’s $722M Acquisition, IQVIA’s Veeva Partnership & More
North Carolina – Regional Life Sciences Roundup -October 16th, 2026 Each week, our Regional Roundup delivers the most important and timely life sciences…
Business taking action for nature at CBD COP17
At the UN Biodiversity Conference (CBD COP17) in Yerevan, Armenia, from 19-30 October, IUCN will show how business can use science, data and technology to scale up its contribution to the Kunming-Montreal Global Biodiversity Framework.
Go back to the medieval times with the Baton Rouge Maker Faire. See when, where, what to do.
Join the East Baton Rouge Parish Library’s Maker Faire for medieval-themed activities, hands-on projects, performances and more.
Can AI solve our mental health access problem?
Last week I asked you what worries you most about AI in health. It was close, but your top answer was “AI giving bad health advice.” Last week’s poll results: You’re in good company. This concern was top of mind at a conference I joined at Stanford last week, where researchers, clinicians, and people who build AI systems spent a day debating trust and safety in health AI. Stepping back, I’m also hearing your emerging concerns about AI’s impact on our well-being generally. I see this as a matter of public health, and we’ll take it in pieces as we learn together. Today we’ll focus on AI chatbots used for therapy for mental health. Early this month, Governor Newsom vetoed Senate Bill 903, California’s most ambitious attempt to regulate AI use for mental health. It’s at the center of active debate, and raises the questions patients, family members, citizens, and voters will face as AI moves deeper into health care. Let’s work through it. What is “AI-based therapy”? It’s really two things: purpose-built mental health apps designed to deliver structured support, and general chatbots like ChatGPT, Claude, and Gemini that people increasingly use for emotional support—even if they weren’t built for it. Spoiler alert: I don’t know whether the shift toward AI therapy is good or bad. The evidence isn’t there yet. But I do know it’s already happening, and I have some ideas about how we can roll it out with safety in mind. The therapy dilemma, in a nutshell Mental health challenges are common, and strain health and well-being across populations. Therapy (interactive dialogue with a trained, empathetic practitioner) helps many people heal. The demand for licensed therapists far exceeds the supply in California, and AI-based therapy can narrow that gap. AI-based therapy remains novel, unproven, and not well tested. Right off the bat, we can see we’re dealing with trade-offs here. Since the main driver of demand for therapy from a robot is lack of access to therapy from a human, we’ll start there. It’s too hard to find and afford a human therapist California is short roughly 55,000 licensed, non-prescribing therapists and counselors, about 40% of what we need. Psychiatrists, who rely on talk therapy as a complement to prescribed medications, are even more scarce. Eight counties have none, and density ranges from 1.7 per 100,000 residents in San Benito County, to 68.1 in Marin County. My wife is a psychiatrist in Marin, and even here access is tight. If it’s hard in the best-supplied county, imagine rural Sierra County, or the San Joaquin Valley. In 2024, more than half of Californians who tried to make a mental health appointment struggled to find a provider who took their insurance, compared with 14% for physical health care. When Senate staff posed as “secret shopper” patients and called 120 mental health providers in Medicare Advantage networks, they landed an appointment less than once for every five tries. Insurers pay behavioral health clinicians about 22% less than medical and surgical clinicians for comparable office visits. On top of that, billing denials and prior authorizations hit hardest at the solo and small practices common in mental health. Psychiatrists opt out of Medicare at the highest rate of any specialty. In many places, a cash practice for therapy fills quickly with patients paying $250 or more an hour, with no insurance paperwork at all. Families who can pay cash find providers more easily. Those who rely on insurance, including Medi-Cal enrollees, older adults, rural residents, and non-English speakers, compete for what’s left. So we can’t pretend the human system works, and we can’t blame people for turning to AI for support when they’re in distress. AI is filling the gap It’s estimated that roughly a quarter of AI users use it for mental health support. If you have internet, it’s available 24/7, it’s cheap, and it speaks your language. Uninsured adults are about twice as likely as insured adults to do it (30% vs. 14%). It feels anonymous in ways that may enable people to ask things they’re unsure or embarrassed about. The largely hidden, personal use makes it hard to study whether it’s actually helping people with their mental health issues, but researchers are trying. Does AI therapy work? A 2026 analysis of nearly 40 randomized trials found chatbots showed a real but small reduction in depression symptoms. But most of these trials were compared to an alternative of no therapy, not a human therapist. So the benefit of AI therapy is probably real, but modest, and mostly untested against the alternative of human contact. We need more studies. Serious concerns OpenAI’s own estimate is that more than a million ChatGPT users each week show signs of suicidal planning or intent. These are high stakes encounters, and AI doesn’t always get it right. That’s partly because a chatbot can sound like a therapist, but it has no license, no duty of care, and it’s not clear who to hold accountable when it gets things wrong. AI is also designed to help users in whatever task they’re seeking to accomplish. People may feel like they’re getting therapy, but they’re mainly getting a convincing conversation. It’s easy for an AI companion to wander into gray areas, like playing along with “creative writing” that may be about the user’s own suicidal intent. Courts are driving safety conversations A wave of lawsuits have been filed on behalf of families claiming that chatbots pushed people they loved toward self-harm, including teens who died by suicide. The first settlements came this year. OpenAI is headquartered in San Francisco, and dozens of cases alleging that ChatGPT drove users to suicide or self-harm are now before a San Francisco judge. Character.ai has filed for bankruptcy after several states brought lawsuits accusing the chatbot of pushing dangerous content to kids. But the technology seems to be improving. Last month, an independent evaluation found that newer AI models “almost never endorse suicide.” That’s progress, but our societal appetite for even one preventable death is very low. So how do we move forward? Finding a middle ground Earlier this month the governor vetoed Senate Bill 903, a bill designed to place guardrails on the use of AI for therapy. The bill would have prohibited any AI-based platform from being advertised as psychotherapy, and would have required a licensed professional to review and approve each encounter where AI was used to support therapeutic decisions. Newsom called it overly broad, since even routine screening questions would have needed clinician sign-off. Knowing we’re already short on mental health providers, requiring human review of AI encounters may not relieve our access problems. Still, the answer isn’t no oversight. Here’s one feasible short term solution. Rather than reviewing each encounter, a licensed clinician can design the guardrails: what counts as a crisis, what triggers an immediate handoff to a human, and what gets sampled for audit each month. The AI runs inside that structure. Conversations get checked, failures get reported, and a real clinician owns the framework. Medicine already has models to learn from. The FDA process for rolling out newly approved medications is an example. After a product reaches patients, we keep watching for adverse events. Patient-facing AI needs the same “digital pharmacovigilance”: systematic tracking of harms, near misses, and the types of groups that get hurt and why. It’s also critical that users know that they can reach a human if they’re in crisis. Most chatbots now include messages like these: Bottom line The rush to use unproven AI tools for mental health support is mostly a workaround, a sign of a health system people can’t get into. We need better access to proven care from licensed clinicians. That takes reimbursement that makes accepting insurance viable, and a bigger workforce. But, built and tested well, AI could be part of the answer. It could be the 2 a.m. check-in when no one else is awake, or a way for patients to practice skills their therapist taught them. It could be the first step to get someone the right level of care, and take paperwork off clinicians’ plates so they spend more time with patients. None of this is simple. The SB 903 veto doesn’t end the debate, and the legislature will be back. In the meantime, those of us using these tools need to stay informed, ask hard questions, and hold the companies building them accountable. I’ll try to do my part, and we’ll keep learning together. Love,Matt P.S. If you or someone you know is struggling with mental health challenges, emotional distress, substance use problems, or just needs to talk, call or text 988- you’ll reach a real person— or chat at 988lifeline.org 24/7. Dr. Matt Willis is the author of Your Local Epidemiologist in California. A California native, he’s served as a primary care physician, CDC epidemiologist, and public health officer for Marin County, where he guided the pandemic response. He lives in Marin with his family and their dogs, Teddy and Ramona. Thank you Cynthia He, MD, PhD, and Parnika Saxena, MD, for their guidance in preparing this article. Cynthia works in an outpatient mental health clinic, treating patients who have Medi-Cal or, sometimes, no insurance. Parnika works in an inpatient psychiatric unit, treating patients with public or private insurance or self-pay ability. All opinions are their own and do not represent their employers.
Math Professor Secures National Science Foundation Grant to Advance Math Education
Professor of Mathematics, Dr. Dana Clahane, was recently awarded a federal grant of $499,893 by the National Science Foundation (NSF). A prestigious award, the grant will elevate undergraduate mathematics education in a project titled “Building Mathematics Research Communities at Two-Year Colleges” (BMRCTYC). Over the next three years, BMRCTYC will establish local Mathematics Research Communities at eight... Read more »
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13News Now
13News Now (WVEC) is made up of storytellers, innovators, content creators, and idea generators. We stand for passion. Passion for our people, passion in our product, and above all- passion in our community. We value honesty, accuracy, and solutions. We serve as the local ABC affiliate for Hampton Roads. We strive for interaction with our audience and are constantly working on our presentation so that you have the best experience when consuming our products. Whether on air, online, or on the go- we are everywhere you go. Digitally we lead the market by more than a million actions over our nearest competitor. Join the conversation with us, help us tell the Stories of Now. About our parent company TEGNA- TEGNA Inc. (NYSE: TGNA) is an innovative media company that serves the greater good of our communities. With 46 television stations in 38 markets, TEGNA delivers relevant content and information to consumers across platforms.
13News Now
13News Now (WVEC) is made up of storytellers, innovators, content creators, and idea generators. We stand for passion. Passion for our people, passion in our product, and above all- passion in our community. We value honesty, accuracy, and solutions. We serve as the local ABC affiliate for Hampton Roads. We strive for interaction with our audience and are constantly working on our presentation so that you have the best experience when consuming our products. Whether on air, online, or on the go- we are everywhere you go. Digitally we lead the market by more than a million actions over our nearest competitor. Join the conversation with us, help us tell the Stories of Now. About our parent company TEGNA- TEGNA Inc. (NYSE: TGNA) is an innovative media company that serves the greater good of our communities. With 46 television stations in 38 markets, TEGNA delivers relevant content and information to consumers across platforms.
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Thursday Morning Links
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Supply Chain Modernization Strengthens Business Resilience
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Is the EU research budget actually increasing?
Is a Horizon Europe budget of €158 billion a 10% cut or a significant increase to the EU’s support for research and innovation? What would seem like a question of fact has divided opinion in Brussels since the Irish presidency of the EU Council presented its negotiation box on October 10. The answer depends on factors such as how you adjust for inflation, whether you account for increases in overall EU wealth and if you care about absolute or proportional figures. The €158 billion budget in current prices, proposed by the Irish presidency of the EU Council, was quickly criticised by university lobbies and rejected by the high-level expert group led by former Portuguese science minister Manuel Heitor. It was also decried by the four pro-European political groups in the European Parliament. “How can Europe close its competitiveness gap while cutting the European Competitiveness Fund by 13% and Horizon Europe by nearly 10%?” asked a joint statement by the European People’s Party (EPP), Renew Europe, the Socialists and Democrats and the Greens/European Free Alliance. Together, these parties hold 63% of seats in the Parliament.In stark contrast, Irish foreign affairs minister Helen McEntee said that the proposal “significantly increases investment in competitiveness, research and innovation,” Meanwhile, a presidency press release said that, compared to the current Multiannual Financial Framework (MFF), the proposal would “double the volume of competitiveness related programmes.” So, who is right? That depends on how you make the calculation.Compared to the Commission figure or the previous budget?The first thing to notice is the difference in baselines. When the MEPs say the Irish presidency will cut Horizon Europe by “nearly 10%” they are using the European Commission proposal for the MFF from July 2025, which allocated €175 billion in current prices to Horizon Europe. However, when the Irish foreign affairs minister said the research and competitiveness budget is increasing significantly, she is comparing it to the 2021-27 MFF, which had a Horizon Europe budget of €84.9 billion in 2018 prices.Her point holds when accounting for inflation. Applying a 2% annual inflation rate, the calculation method used by the Commission, the 2021-27 Horizon Europe would have a budget of €97.5 billion in 2025 prices. In comparison, the Irish presidency’s €158 billion figure in current prices translates to €140 billion in 2025 prices. Does the ECF count?But there is more to the dispute. In its statements, the Irish presidency lumped the research budget in with the overall budget for competitiveness. The Parliament statement, however, kept the two separate. This matters because the next MFF includes plans to add a new European Competitiveness Fund (ECF) to fund programmes meant to boost the continent's competitiveness. The Irish negotiating box allocated €245 billion in current prices to this programme.When this is added to the €158 billion for Horizon Europe, as well as programmes such as the EU education programme Erasmus+, the total for “competitiveness, prosperity and security” in the Irish proposal becomes €514 billion in current prices. But it is still uncertain how big a share of this competitiveness budget would go to research. The Commission proposal of July 2025 for the MFF included clear links between the ECF and Horizon Europe, indicating some ECF money will go to research. At the same time, the structure of the ECF is still being negotiated, and a substantial part of its budget is expected to support non-research activities such as defence manufacturing, decarbonisation and digital infrastructure. Related articlesCouncil floats 9.6% budget cut to next Horizon EuropeResearch community to appeal to national governments over planned EU budget cutEU own resources ‘essential’ for future research budget, says leading MEPSo, it is by looking at competitiveness rather than research, or combining the two, that the Irish presidency can claim that its proposed budget will significantly increase investment in competitiveness, research and innovation.According to the Irish presidency proposal, Horizon Europe and other competitiveness-related programmes in the current multiannual budget received €221 billion in current prices. However, since this money is being distributed from 2021 to 2027, it is not directly comparable to the €514 billion in current prices which will be distributed from 2028 to 2034.Research as a proportion of the MFFBut the relative rise in competitiveness-related programmes points to another important distinction: whether you look at the research budget in absolute terms or as a share of the overall MFF. Here, too, the size of the research budget has risen, although only slightly. In the 2021-27 MFF, Horizon Europe accounted for 7% of the total budget. In the Irish presidency’s proposal, it amounts to 8.7%. The share for the total competitiveness envelope went from 17.7% in the current MFF to 28.1% in the Irish presidency proposal.This proportional share may seem irrelevant to universities looking for research funding, but it is becoming significant as budget negotiations between the Parliament, the Commission and the Council begin. On October 2, a group of 17 southern and eastern European countries sent out a statement calling for the EU agriculture and cohesion budgets to be protected. The Parliament’s co-rapporteur on the budget, Siegfried Mureșan of the EPP, has also said that the research envelope is likely to be cut disproportionately as the budget is slimmed down during negotiations.
Why Los Angeles Chargers Could Trade Star Linebacker
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Louisiana opens enrollment for 274,000 Medicaid recipients who must switch plans
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