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Loma Linda University Health and Lifepoint Rehabilitation Break Ground on new Inpatient Rehabilitation Hospital in Loma Linda
Loma Linda University Health and Lifepoint Rehabilitation, an operating division of Lifepoint Health, celebrated a major milestone today as they officially broke ground on the new Loma Linda University Rehabilitation Hospital, a free-standing hospital that will include 80 dedicated rehabilitation beds. “For three decades, our East Campus Hospital has provided comprehensive rehabilitation services to those […]
Dr. Mark Wooden celebrated science, GCU celebrated him at retirement event
Photos by Ralph Freso / Slideshow When Dr. Randy Gibb landed on the Grand Canyon University campus in 2014 as the new dean of the […]
U.S. Says It Revoked More Than 175,000 Visas Under Trump
Most visas were rescinded over criminal accusations, the State Department said, while some were revoked from people who had celebrated the assassination of Charlie Kirk.
ND Expert on democracy: Can better civics education restore voter dissatisfaction over political corruption?
This summer, America celebrated the 250th anniversary of the signing of the Declaration of Independence, widely recognized as the formal founding of our nation and one of the early stages of establishing a democratic government. Over the past two decades, however, democracies all over the world have struggled with a lack of clear support. Democracy scholars have referred to these challenges as evidence of backsliding, a phenomenon that has many political and social scientists concerned, including Notre Dame development economist Enrique Seira Bejarano.
The Future Of Young Hollywood Is Bright, Thanks To These Rising Stars
Variety's Young Power of Hollywood event celebrated the next generation of rising stars, honoring Tyriq Withers, Tate McRae, Sombr, and Malachi Barton, proving that the future of the industry is in good hands.
Ella’s Top Corral celebrates 50 years of business
On Aug. 6, Ella, the woman behind the name of ‘Ella’s Top Corral,’ celebrated her birthday.
Ella’s Top Corral celebrates 50 years of business
On Aug. 6, Ella, the woman behind the name of ‘Ella’s Top Corral,’ celebrated her birthday.
AI Texas Gold named Business of the Month
ROCKPORT — Rockport-Fulton Chamber of Commerce recognized A1 Texas Gold as Business of the Month for August. Chamber Board Members, Small Business Council, and staff along with special guests celebrated
The Honor Bar & Grill celebrates grand opening in Galivants Ferry
A familiar restaurant location entered a new chapter Saturday as The Honor Bar & Grill celebrated its grand opening and ribbon cutting in Galivants Ferry.
Blizzard is now the "top performing" Xbox studio, says internal emails — as the Overwatch-maker ends FY26 over-delivering on Microsoft's projections
In leaked emails verified by Windows Central, Blizzard President Johanna Faries celebrated the Xbox division's stunning growth, over-delivering on expectations.
‘It’s impactful’: Seattle Sports fans see a bright future at stadium gatherings
Two major sports events took place in Seattle on Saturday. The Super Bowl-winning Seahawks held their Fan Fest, and the Mariners celebrated 50 years of Seattle baseball as the team hosted the Tampa Bay Rays.
To the editor: Ohio rates as top state for business
The Toledo Blade editorial on July 12 celebrated Ohio’s rating as the top state for business by CNBC. The editorial did mention one caveat “Educational ...
Editorial: Trump admits his funding decisions driven by politics, revenge
Governing in such a manner is contemptible and contradictory to the founding principles that Americans celebrated on Independence Day this year.
They’re Battle-Tested Democrats. Do Voters Care?
Haley Stevens and Angie Craig were celebrated by Democrats in 2018. This year, they’ve faced tough primaries.
A decade of heart: Camp Lionheart celebrates 10 years
Camp Lionheart recently celebrated its 10th anniversary, bringing together children and teens with heart disease for a week of traditional summer camp activities in a medically supported environment.
OU Health secures $750,000 grant for state’s first comprehensive pediatric behavioral health center
OU Health officials celebrated the grant Tuesday, which will support the project's general fund.
New Orleans had its own version of 'American Bandstand' in the '60s: 'The John Pela Show'
Pela, who recently celebrated two landmark occasions in May — his 95th birthday and his 75th wedding anniversary — has always been a fan of music.
Nat Falk celebrates 90 years of business in Ware
A men’s clothing store in Ware celebrated 90 years in business.
Glenwood Marketplace helps local business owners grow in the community
LEAD Coalition celebrated second anniversary of the Glenwood Marketplace.
Does public health *need* MAHA?
Last week, our friend Dr. Craig Spencer sparked an ongoing volatile discussion with his Atlantic article “Public Health Needs MAHA.” Some have come out in strong dissent, others are cheering, and others are simply lamenting that we find ourselves in such a divided world to begin with. We will dare to dip our toes in these controversial waters, too. Does public health need MAHA? We think in some ways yes, and in other ways, no. MAHA leaders versus the everyday MAHA supporter The vitriol in this debate mostly comes from one collapsed distinction: the leadership of MAHA is not necessarily the same as the people who support it. Say “MAHA” and most people picture RFK Jr. Fair enough, as he coined the term and holds most of the power. And, yes, some MAHA followers treat Kennedy as something close to a saint. But talk to the grassroots, and it’s not a monolith. They’re Republicans, Democrats, and Independents. People who distrust vaccines and vaccine supporters. It’s a wide, eclectic coalition. The data backs this too: 4 in 10 Americans support the movement—that’s a lot of people! But according to polls, vaccines and medical choice (the issues most tied to Kennedy personally) are cited by only 4% as their reason for supporting the movement. For many, the motivations are much broader. Many MAHA supporters are signing up for the idea that “something needs to change” with health in this country. They’re asking good-faith questions about corporate influence on our health systems, health care costs, nutrition, chemicals, and clean air and water. These are all questions that plenty of public health professionals recognize as legitimate and also care about very deeply. Blurring the lines between the leadership and grassroots does real damage in two important ways: It hands the 4 in 10 exactly the narrative already fed—that the health ecosystem doesn’t listen, doesn’t care, and paints every critic with the same brush. It gives the actual bad actor more power. RFK Jr. has done irreparable damage and can’t be trusted. What the MAHA movement gets right A healthy population is something the public health field was literally built on, and many of these topics are things we have dedicated our lives to. Yet the MAHA movement has captivated nearly half the country in a way the public health establishment has failed to achieve. So that means MAHA is doing something right. Some of it may be timing (after a Covid-19 pandemic and deep frustration and mistrust with institutions). The movement also does three other things really well: 1. It gives a new, louder voice to system failures. While MAHA is not a monolith, one theme stays consistent across their stories: the system failed them. For some, it was the system that flooded their communities with opioids and then walked away. For others, it was the system that let their business collapse during Covid with no safety net in sight. For others still, it was the system that failed to help them manage a complex chronic illness, bouncing them from physician to physician without any real answers. And in many ways, our health ecosystems are failing Americans. Why are medical bills so incomprehensible? Why do some kids get a healthy school lunch and others don’t? Why do an epidemiologist and a MD/PhD student have to start newsletters in the middle of the biggest public health emergency in a century, just so people can get straight information? Because the systems failed. This deep-seated frustration driving many Americans to search for solutions elsewhere needs to be recognized. 2. MAHA has brilliant comms central to their efforts. MAHA figured out something most health institutions still have not: the information landscape changed. It’s participatory now, not top-down; influence runs through many nodes in a community, not one institution; and storytelling and telling audiences “what you really think” moves people more than data dumps do. MAHA goes where audiences are listening, using podcasts, social media, and memes in ways most health institutions would scoff at—but it works. 3. They are very good at organizing. A MAHA meeting feels like a rally: energy, speakers, music, and most importantly, an action for everyone. Someone’s writing the next policy brief, someone’s seeding a narrative, someone knows the next legislative deadline, someone’s sending the text messages for a campaign. None of this is new (ask the civil rights movement), but MAHA knows it works and has capitalized on it. What MAHA gets wrong This list could be much longer, and this newsletter has spent a lot of time covering it, but here are a few things: Poor use of scientific evidence. This is the fundamental problem with many MAHA policies: the hype outpaces the science, and experts are often villainized for pointing this out. MAHA leadership has traded real solutions for cheap wins. For example, instead of taking on the powerful food industry and passing real reforms, it has celebrated french fries made of beef tallow and taken out artificial dyes from still very sugary children’s cereal. These changes won’t move the needle on America’s diet. MAHA leadership has tried to dismantle vaccine access in the U.S. While many MAHA supporters emphasize other issues, the effort to change vaccine policy has become MAHA’s signature effort. This is not surprising given RFK Jr.’s extensive track record campaigning against vaccines. It has rallied behind the wrong leader. RFK Jr. has a decades-long track record of villifying doctors, scientists, and public health workers, well before he became HHS secretary. He is known for his decades-long work sowing distrust in vaccines as well as life-saving treatments like antiretroviral therapy for HIV. This is not a serious person who can move the needle on health in the U.S, and he has already done serious damage. Public health needs more than defense Defending the evidence is absolutely necessary so health in the U.S. doesn’t move further backward. The public health establishment is very good at defense. The problem is this defense often sounds like defending the status quo, which has failed many people. Public health needs to offer an alternative to RFK Jr.’s MAHA—one that is rooted in evidence, truly listens to and addresses people’s frustrations, and has innovative solutions and the courage to change the systems. How do we get there? Find common ground. Do you know what most people care most about? The abysmal cost of healthcare. Start there. Fight for the human loudly. Too often, communications and engagement center on science with a capital S, funding mechanisms, or the CDC/FDA/NIH. Not the person. So the public doesn’t see themselves in it. Instead, they see people fighting for the very powerful systems that they feel negatively impact their health and well-being. Let the public feel and hear that you see their frustrations, you get it, and you’re fighting for them within the system. Recognize when pro-science messages are alienating people. Facts absolutely matter, but angrily venting only alienates people further. Our friend Elisabeth Marnik recently wrote a New York Times article about her experience growing up unvaccinated and how listening and empathetic conversation are the only ways to reach people that really work (a position backed by communication science). Her comments section was full of hateful comments from pro-vaccine individuals attacking her for daring to suggest we approach vaccine-hesitant individuals with empathy. It is possible to both stand firm behind scientific evidence and empathize with people who don’t trust it. Lean into politics smartly. Often, public health has shied away from politics: Don’t touch it, lest you get burned. But this fails to recognize that the third rail is what fuels the train: who is elected determines our budgets, our priorities, and our authority. Being political means being very savvy in strategy on both sides of the aisle, knowing your audience, and recognizing that political capital is as scarce as financial resources and needs to be allocated accordingly. Bottom line So does public health need MAHA? That’s not really the right question. Public health has a responsibility not to dismiss 40% of the country who feel heard by this movement and are frustrated that the system has failed them. And it has a responsibility to stick to the evidence and recognize MAHA leadership for what it is: a danger to our nation’s health. Both can, and should, be done. Love, YLE and KP A big thanks to Craig Spencer, who had the courage to put his neck out there to start a much-needed discussion at such a critical moment—one that is determining the identity of an entire field. Kristen Panthagani, MD, PhD is completing an emergency medicine residency and research fellowship focusing on health literacy and communication. In her free time, she writes the newsletters You Can Know Things debunking health myths and rumors and The Public Health Roundup. Views expressed belong to KP, not her employer. Your Local Epidemiologist (YLE) comprises a team of experts, ranging from physicians to immunologists to epidemiologists to nutritionists, working together with one goal: to “translate” ever-evolving public health science so that people are well-equipped to make evidence-based decisions. The YLE suite of newsletters reaches over 475,000 people across more than 132 countries. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
'We're committed to this region' | New hospital expands Margaret Mary Health in rural Indiana
In a time when rural hospitals often struggle to keep doors open, Margaret Mary Health celebrated the opening of a $125 million facility in Batesville Thursday.
The Yankees All-July Birthday Team
With July coming to an end, let’s make a lineup of Yankees who celebrated a birthday this past month.
Abound Health celebrates ADA Anniversary with inclusive bowling event in Murphy, N.C
Abound Health celebrated the 36th anniversary of the Americans with Disabilities Act with an inclusive bowling event that brought clients, support staff, and co
PMI U.S. Opens $1.2 Billion Aurora Campus, Strengthening U.S. Manufacturing and Export Capabilities
Philip Morris International Inc.’s (PMI) (NYSE: PM) U.S. businesses (PMI U.S.) today celebrated the opening of its Aurora, Colorado manufacturing campus, a l...
Geneva celebrates opening of Seneca W.A.V.E.
GENEVA — The city and Geneva Community Projects celebrated the official launch of Seneca W.A.V.E. — Waterfront Access, Views and Events — July 19 with a free, family-friendly community celebration
250 Years of America Celebrated at Rome's Honor America Days
Honor America Days are returning to the City of Rome as the community gets ready for a day of celebrations.
The Best Stadiums in Sports Are at the Tour de France—and Completely Free
As the race heads to the Alpe d’Huez for two stages, before a final-day fight on the streets of Montmartre, hundreds of thousands of fans are flocking to the most celebrated roads in cycling.
NYC Health + Hospitals/Kings County Celebrates Inaugural Ceremony of Kings CARES, Strengthening Support for Survivors of Domestic and Gender-Based Violence
NYC Health + Hospitals/Kings County celebrated Kings CARES with an inaugural ceremony, recognizing the hospital's survivor-centered program that has
Maid Brigade Leadership Summit Highlights AI Innovation, Business Growth and Franchise Excellence
Maid Brigade franchise owners from across North America gathered July 16-18 at The Source Hotel in Denver for the 2026 Maid Brigade Leadership Summit, where they explored innovative business strategies, shared best practices and celebrated franchise excellence.
Fayetteville business celebrates 50th anniversary
One Fayetteville business celebrated its 50th anniversary over the weekend.
Sister Cities Celebrated 40 years at the Duluth Entertainment Convention Center
Welll...The smokey air didn't stop a global celebration today.The decc was filled with culture... Food... And community tonight...As "Sister cities" hosted its first-ever dock and dine event.The nonprofit also celebrated
Giving old sweaters ‘Anu’ life: Greenfield business celebrates one year of upcycling cashmere into new winter sportswear
Greenfield based company Anu recently celebrated its first anniversary since beginning its journey of upcycling used cashmere sweaters into neck warmers, reducing exposure to microplastics and toxins in outdoor wear.
Science Grant Could Deliver $160M For Quantum Tech In CT
At a gathering held at the UConn Hartford campus, state leaders celebrated Connecticut being selected as a Regional Innovation Engine for quantum technologies by the National Science Foundation.
Nvidia’s Jensen Huang reunites with Sega exec who saved the company with $5M investment
Sega and the world’s richest company celebrated a new partnership in Tokyo…
ESPN's 2026 Sports Humanitarian Awards honors people using power of sports for good
The 12th annual award ceremony celebrated athletes, teams, leagues and members of the sports industry who use the power of the sport to make a positive impact on society and communities.
ESPN's 2026 Sports Humanitarian Awards honors people using power of sports for good
The 12th annual award ceremony celebrated athletes, teams, leagues and members of the sports industry who use the power of the sport to make a positive impact on society and communities.
ESPN's 2026 Sports Humanitarian Awards honors people using power of sports for good
The 12th annual award ceremony celebrated athletes, teams, leagues and members of the sports industry who use the power of the sport to make a positive impact on society and communities.
ESPN's 2026 Sports Humanitarian Awards honors people using power of sports for good
The 12th annual award ceremony celebrated athletes, teams, leagues and members of the sports industry who use the power of the sport to make a positive impact on society and communities.
Doctor of Health Sciences students celebrate culmination of academic journey
Campbell University’s Doctor of Health Sciences program celebrated a major academic milestone as 27 students gathered to present their capstone… More on this post
At Family Science Night, Wonder Comes Before Answers.
BAR HARBOR—Family Science Night isn’t really about science. It’s about wonder. It’s about watching a five-year-old realize that the tiny creature under a microscope is a real living thing. It’s about a teenager discovering that the scientist explaining genetics or regeneration isn’t much older than they are. It’s about parents seeing curiosity spread across a child’s face the way excitement spreads across a crowd at a Fourth of July parade. For one evening, families realize that the laboratory isn’t some secretive place where knowledge is hidden behind white coats and closed doors. They learn that the lab is a place their neighbors work, their friends’ parents work, and it becomes a place where questions matter more than answers. It’s a place where wonder is the origin for knowledge. At the lab, children learn that it’s okay not to know. Adults remember that they once asked “Why?” about everything. Scientists are reminded why they fell in love with discovery in the first place. There are experiments, games, obstacle courses, and demonstrations, of course. But those are really just invitations—to touch, to explore, to laugh, to make mistakes, and to ask one more question. In a world that often rewards certainty, Family Science Night celebrates curiosity. And perhaps that’s its greatest gift. Long after the microscopes are packed away and the experiments are over, what families take home isn’t just a few new facts about biology. They take home the feeling that discovery belongs to everyone—that science isn’t something happening somewhere else by someone else. It’s simply what happens when people are given permission to wonder. A Family Science Night at the Mount Desert Island Biological Laboratory is one of those rare community events where children and adults can experience science as something they do, not just something they read about. Hands on discovery allows hands-on learning and joy. Real scientists, some local, some scientist-interns (but still scientists) just in college make science real, approachable, and exciting. And there, complex ideas like forever chemical-filtration, DNA and so much more become not complex. Instead, they become fun. Summer fellows are challenged to explain cutting-edge biomedical research in ways a first-grader—and their grandparent—can understand. Past activities have explored gene expression, kidney function, axolotl regeneration, worms, microplastics, and phytoplankton through games and creative demonstrations. Though it’s called family night, you can also see adults going from station to station, exploring, learning together across ages. Family Science Night reflects the laboratory’s broader mission of breaking down barriers between researchers and the public, helping people understand how scientific discoveries relate to everyday life and the health of Maine’s environment. Family Science Night transforms a world-class research laboratory into a giant interactive classroom, where curiosity is encouraged, questions are celebrated, and families discover that science isn’t just something that happens in a lab—it’s an adventure anyone can join. About MDI Biological Laboratory For more than 125 years, MDI Bio Lab has been a center for training and research in comparative biology. In the last two decades its biomedical research has focused on aging, regeneration, and environmental toxins. The Laboratory houses 11 research groups staffed by an international team of world-class scientists and graduate students. It also leads a statewide network of colleges, universities and research institutions that collaborate to provide training, research experiences and financial support to help young Mainers play a bigger role in today’s biomedical revolution. Located on Maine’s rugged coast, the Laboratory’s 100+ acre campus houses research facilities, cottages and dorms that house visiting scientists and students. It is also home to MDI Bioscience, a subsidiary working to design innovative techniques to speed the drug discovery process. LINKS TO LEARN MORE NIH INBRE MDI BIOLOGICAL LABORATORY Photos: Carrie Jones and Shaun Farrar/Bar Harbor Story HELP SUPPORT THE BAR HARBOR STORY When we started The Bar Harbor Story, we didn’t know if anyone would read it. But you showed up. You shared. You sent tips. Now—over 400,000 views every month later—it’s clear: people here care about their community and each other. We’ve kept everything free because news should never be out of reach, but every one of our stories takes time to write, and your support keeps The Bar Harbor Story going. If you value our work, please consider a paid subscription, a founding membership, or a sponsorship. It truly helps us cover one more meeting, tell one more story, shine one more light. Even $5 a month makes a difference. Click here to become a one-time supporter now. Thank you so much for being here. Founding member information can be found here. Have questions about sponsorships? Just send Shaun an email at sfarrar86@gmail.com, he’d love to hear from you. Subscribe Share Bar Harbor Story Share Leave a comment
Gov. Whitmer announces Michigan ranked #6 in best states for doing business
LANSING – On Thursday, Governor Gretchen Whitmer celebrated Michigan’s No. 6 ranking from CNBC’s America’s Top States for Business, earning a Top 10 ranking for a fifth time under Governor Whitmer’s leadership and representing a massive leap from No. 24 at the start of her administration in 2019. “Michigan is a place where everyone can […]
York, Hanover Community's Choice Awards winners celebrated
Businesses and organizations gathered Tuesday to celebrate the York and Hanover Community's Choice Awards winners at a gala in York.
Health, Exercise, and Sport Sciences Graduates Have 100% Placement Rate
When Meredith’s Class of 2026 turned their tassels at commencement in May, the Health, Exercise, and Sport Sciences (HESS) program also celebrated a 100% placement rate for its graduates.
Kentucky, Rhode Island towns highlight July 4 celebrations without ‘political conversations’
Millions of Americans celebrated the country’s 250th birthday on Saturday, with cities large and small coming together to mark the occasion in their own ways. That includes Somerset, Ky., and Brist…
Denton’s Fourth of July 2026
Denton celebrated the United States’ 250th birthday on Saturday, July 4, with the Yankee Doodle Parade in downtown and a fireworks show in the evening, presented by the Denton Noon
Luv Handlz celebrates four years in business with community event, unveils new froyo truck
Families stopped by Luv Handlz on Sunday as the Syracuse frozen yogurt shop celebrated four years in business with a customer appreciation event.The celebration
Fireworks, heat, hot dogs and politics: America celebrates its 250th birthday
The signing of the Declaration of Independence, one of history’s most celebrated articulations of democratic ambitions, is being marked in myriad ways.
Sports world turns out for Travis Kelce and Taylor Swift's Madison Square Garden wedding festivities
Adam Sandler officiated the ceremony as athletes like George Kittle, Kareem Hunt and Matthew Stafford celebrated at Madison Square Garden.
Carolina’s School of Data and Information Sciences launches
In a campus message, Executive Vice Chancellor and Provost Magnus Egerstedt celebrated the “critical milestone” as the University builds on strengths in information, library and data sciences
How Investors May Respond To PENN Entertainment (PENN) Aurora Casino Opening And Russell 2000 Shift
PENN Entertainment recently celebrated the grand opening of its new US$360 million Hollywood Casino and Hotel Aurora in Illinois, while also being moved from the Russell 1000 family of indices into the Russell 2000, Russell 2000 Value, and Russell 2000 Dynamic indices as part of the latest rebalancing. This combination of a large-scale brick-and-mortar investment and a shift toward small-cap and value-oriented index inclusion reshapes how both fundamental and index-tracking investors may...
FSU Jim Moran Institute celebrates completion of entrepreneurship bootcamp for veterans' families
Florida State University’s Jim Moran Institute for Global Entrepreneurship (JMI) celebrated the successful completion of its 2026 Entrepreneurship
Jazz Under the Stars returns August 6
KCCK's Jazz Under The Stars celebrated the station's 50th anniversary last year by reuniting some of Iowa's best-known jazz, blues and R&B performers. Iowa's Jazz Station kicks off its second
Hollywood celebrates Mel Brooks' 100th birthday
Mel Brooks' 100th birthday is being celebrated by friends, fans, and the whole of Hollywood.
Landry Jones, Courtney Frerichs headline 2025 New Mexico Sports Hall of Fame class
ALBUQUERQUE, N.M. (KRQE) – Some of the biggest names in New Mexico sports were celebrated Saturday night as the New Mexico Sports Hall of Fame inducted its Class of 2025. This year’s class r…
VIA Women’s Health Collective celebrates grand opening
By Megan Dial VIA Women’s Health Collective, 17300 Westfield Blvd., Suite 330, celebrated its grand opening June 18 with the Westfield mayor, Westfield Chamber of Commerce and other community supporters. Dr. Taylor Hahn said she founded VIA Women’s Health Collective to support women in every s
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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How Should Sport Identify Its Future Leaders?
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