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Brooks Nader Reveals How She ‘Manifested’ Role in New ‘Baywatch’ Reboot
'My superpowers are scaring me.'
A Veteran Group Jumps In for a Democrat in Iowa Senate Race.
VoteVets is the first super PAC to intervene in the race for Josh Turek, a state legislator who was born with spina bifida after his father was exposed to Agent Orange in Vietnam.
Supercomputers just solved a 50-year-old mystery about giant stars
Astronomers have finally cracked a decades-old mystery about red giant stars—how material from their deep interiors makes its way to the surface. Using cutting-edge supercomputer simulations, researchers discovered that stellar rotation plays a powerful role in mixing elements across a previously unexplained barrier inside the star.
Microsoft hires former Ai2 CEO Ali Farhadi and key researchers for Suleyman’s AI team
Microsoft is hiring former Ai2 CEO Ali Farhadi, along with Hanna Hajishirzi and Ranjay Krishna from the Allen Institute for AI to join Mustafa Suleyman's Superintelligence team, GeekWire has learned.
Microsoft Aims to Supercharge Windows Performance and Cut RAM Waste in 2026
Perhaps this would help return some of the goodwill it lost in 2025.
Pop superstar announces summer concert tour, including stop in central Pa.
"The Freedom Tour" will make a stop in Hershey this August.
This Web Tool Sabotages AI Chatbots By Making Them Really, Really Slow
Artist Sam Lavigne created ‘Slow LLM’ to make people question their dependence on tools like Claude and ChatGPT. Or at least, make them super annoying to use.
Intel Core Ultra 7 270K Plus & Core Ultra 5 250K Plus Official Benchmarks: Faster Than 14900K & Comparable To Ryzen X In Gaming, Much Faster In Apps, Superb Value
Intel shared official benchmarks of its Core Ultra 7 270K Plus & Core Ultra 5 250K Plus in gaming, apps, and more, against AMD Ryzen CPUs.
The debate over Trump’s mental health: ‘Malignant narcissist ’ or ‘superhuman president’?
While some warn of the danger of having someone suffering from ‘cognitive decline’ in the White House, his inner circle attributes his outbursts to his iconoclastic personality
Country music has a new supergroup: Meet the Cowgays
The group just released its first song.
Carrie Anne Fleming, 'Supernatural' and 'iZombie' actress, dies at 51
Carrie Anne Fleming, who appeared on 3 episodes of 'Supernatural' as Bobby's wife Karen, has died. She was 51.
Man who bought $75 worth of Apple products from a stranger in a car park realizes he might be sitting on a small fortune
A tech enthusiast who bought a bunch of used Apple products off a stranger in a car park was left pleasantly surprised by the haul
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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El Paso health inspectors found 39 violations at Valley Supermarket and Phoenix Palace Restaurant in February inspections.
Healthcare Uses Specialized Language. It Needs Specialized AI, Too.
The potential generative AI in healthcare is enormous. They can generate patient education materials or clinical notes in seconds, flag incomplete documentation to keep care on track, or even suggest differential diagnoses . But when generalist models encounter the specialized “dialects” used across medical fields, they can miss critical clinical meaning—even when they read every word correctly. The result can be flawed decisions and eroding clinician trust. Healthcare organizations should treat AI like a supervised trainee: adapt models to clinical specialties, require transparent reasoning, and calibrate automation with human oversight.
CERN Science Gateway celebrates its 1000th science show
CERN Science Gateway has reached another milestone: the delivery of its 1000th science show! Since opening its doors in October 2023, Science Gateway has welcomed nearly 900 000 visitors of all ages to explore the fundamental questions of the Universe. Among its most popular activities are the science shows – dynamic, interactive demonstrations led by CERN guides and tailored to a broad audience of different age levels, including school groups, families and the general public. Designed to make complex scientific concepts accessible and entertaining, these live shows combine spectacular experiments, multimedia elements and audience participation. From the physics of particle collisions to the properties of superconductivity, electromagnetism and cryogenics, the science shows translate the research carried out at CERN into engaging visual experiences. Visitors might see superconductors levitate, follow particles through different detector layers or discover the beauty in phase transitions. Each demonstration is carefully crafted to spark curiosity while maintaining scientific accuracy. Members of the CERN community are of course warmly invited to visit CERN Science Gateway with their family or friends and attend one of the science shows. To register, please visit this page, and don’t forget to check the programme for the coming days. Become a CERN guide and run your own super-cool science show (and more)! To become a CERN guide, you can join the introduction course held every 3–4 weeks, which will give you an overview of what being a CERN guide entails. From there, further courses are available depending on what type of guide you would like to be. Because, of course, CERN guides are needed everywhere at CERN. If you imagine yourself as a more ‘traditional’ guide, you should know that there are currently more than ten exciting visit points in CERN’s visits portfolio, such as the Antimatter Factory, the ALICE experiment (surface), the Alpha Magnetic Spectrometer (AMS) control room, the ATLAS experiment (surface), the CERN Control Centre (CCC), the Data Centre, the LHCb experiment (surface), the Synchrocyclotron (SC), the SM18 test facility and the newly inaugurated Linac2 visit point. Indeed, CERN’s Visits Service and Visual Impact and Exhibitions Section recently collaborated on redesigning the Linac2 visit tour, which has just reopened to the public after several months of renovation work. The new tour offers visitors and guides alike an enriched, more immersive experience, designed to highlight the history and scientific significance of this major facility. So, fancy becoming one of the insiders? Join the introduction course, check the guides website or contact guides.manager@cern.ch. And remember, becoming a guide can benefit you, too.
Cycling’s ‘Big Six’: The super-teams with a growing stranglehold at the top of the sport
Does a growing financial disparity in the men's WorldTour mean races are becoming more predictable?
Humble beginnings, Ronaldo & NBA - how Kvaratskhelia became a star
Guillem Balague analyses the rise of Paris St-Germain's Georgian superstar Khvicha Kvaratskhelia.
Former supermodel says business managers stole millions
Kathy Ireland and her husband Greg Olsen filed suit in Santa Barbara against their longtime managers.
'Stealth hit' Pokemon game sends Nintendo shares soaring
Fan buzz around life-simulation game "Pokemon Pokopia" sent Nintendo shares soaring on Wednesday, with some hailing the new title as a welcome antidote to global conflicts.Nintendo shares were up nine percent in mid-morning trade on Wednesday, also likely boosted by the release of the final trailer for the star-studded upcoming "Super Mario" movie sequel.
Pitbull to turn childhood Wynwood home into his entertainment headquarters
The South Florida home where global superstar Pitbull grew up will soon house his empire.
Scientists discover tiny plant trick that could supercharge crop yields
Researchers have uncovered a molecular trick used by hornwort plants that could help future crops capture carbon dioxide more efficiently. A unique protein feature called RbcS-STAR causes the key photosynthesis enzyme Rubisco to cluster into dense compartments, helping it work more effectively. When scientists added this feature to other plants, Rubisco reorganized in the same way. The finding raises the possibility of engineering more efficient photosynthesis into major crops.
Ocean warming may supercharge a tiny microbe that controls marine nutrients
As deep-sea waters warm, scientists expected trouble for the microbes that help keep ocean chemistry in balance. Instead, researchers found that Nitrosopumilus maritimus can adapt to warmer, iron-limited conditions by using iron more efficiently. Because these microbes control key nitrogen reactions that support marine life, their adaptability could help sustain ocean productivity. In a warming world, they may play an even bigger role in shaping marine nutrient cycles.
LA County sees drop in homeless deaths, the first in 10 years
While the news was welcomed by Los Angeles County supervisors and public health officials, they agreed that the mortality rate was still too high.
Ford launches new AI to grow multibillion-dollar Pro commercial business
Ford CEO Jim Farley last month said diversifying Pro's revenue — specifically in software — is a crucial growth area for the company.
Lego Gives in, Will Finally Make Mario Minifigures
The Lego and 'Super Mario Bros.' collaboration will bend to fan demand starting in 2027.
AppLovin: A Superstar Today, But I Envision Future Turmoil For The Business (Downgrade)
AppLovin Corporation is downgraded to Strong Sell, but operationally and financially looks great. Learn more about APP stock here.
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Nintendo Details New Features For Super Mario Bros. Wonder
It also turns out to be another Switch 2 $80 game