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Trump Doled Out $45,000 Cash Gifts to Natalie Harp and Other Aides Last Year
The money, listed as “cash gift for the holidays,” was detailed in financial disclosure forms released by the administration.
Trump Doled Out $45,000 Cash Gifts to Natalie Harp and Other Aides Last Year
The money, listed as “cash gift for the holidays,” was detailed in financial disclosure forms released by the administration.
UConn Student Justin Fargo Went from Family iPhone-Fixer to Small Business Cybersecurity Champion
'There is a massive shortage of security professionals, and the opportunity for information security-related roles is only increasing'
Seminoles Surrender Back Breaking Play in 4th Quarter
FSU suffered a blow in the fourth quarter when SMU wideout Yannick Smith caught a 79 yard touchdown. Even though FSU responded, it was the biggest explosive play of the game, and the one that sticks out the most when you consider SMU had three plays of 50 yards or more, and eight plays of +15 yards.
How the Texas Attorney General Got This Way
Greg Abbott and Ken Paxton transformed the role from bureaucrat to culture warrior. What comes next?
Curbing pay-to-play in Chicago politics
Close a loophole to limit political donations from city contractors. Also, data centers, ICE, right-to-die law and the Bears.
Ingenovis Health names new chief commercial officer
Nicole Gable joins Ingenovis Health as chief commercial officer to lead strategy for the Blue Ash-based health workforce staffing company.
Ingenovis Health names new chief commercial officer
Nicole Gable joins Ingenovis Health as chief commercial officer to lead strategy for the Blue Ash-based health workforce staffing company.
Darnbrough to leave Port Vale recruitment role
League Two club Port Vale announce their senior head of recruitment Lee Darnbrough will leave at the end of this month.
BridgePort Financial Solutions Appoints Osaic M&A Leader to Senior VP of Business Development
BridgePort Financial Solutions ("BridgePort"), a registered investment adviser (RIA) dedicated to helping fee-only advisors achieve their growth and succession goals, announced the appointment of RIA industry veteran Tina Decker to the role of Senior Vice President of Business Development. In this role, she will lead M&A strategy and execution to accelerate the firm's growth.
Fans face record prices for Ole Miss vs LSU game
Tickets for the Ole Miss vs LSU game are starting above 500 dollars as demand surges for the anticipated matchup.
Grand Theft Auto VI: can playing a video game count as cheating on your partner?
Historically a new Grand Theft Auto game inspired controversy around violence – but this time people are getting exercised about its romance
After a decade as GOP’s main character, Trump gets one more starring role at midterm convention
For a decade, President Donald Trump has made himself his party’s main character — a singular force around whom its rallies, conventions and political identity have revolved.
3 minutes vs. 90 minutes: Which workout is better for your health?
A new study found that three minutes of intense exercise floods our blood with molecules linked to better health.
Comviva announces Kalyanasundaram Sivasubramaniam to lead the DigiTech Business, Accelerating Platform-Led Growth and AI Transformation
Comviva, a global leader in digital transformation solutions, today announced the appointment of Kalyanasundaram Sivasubramaniam as Product Unit Head for its DigiTech business. In this role, he will lead the strategic growth and evolution of Comviva's DigiTech portfolio, including its intelligent digital business platform, BlueMarble.
Women on parole face higher rates of mental health, housing challenges
Women on parole report higher rates of housing instability, poor health and serious mental health and substance use disorders than men on parole and women who weren’t on parole, according
When will Baleba make his Man Utd debut?
Manchester United made the signing of Carlos Baleba a pretty big deal by parading him onto the pitch before last month's Premier League victory over Ipswich. Man Utd made midfield recruitment a summer priority, so what happens now? On the early evidence, it will be either Kobbie Mainoo or Youri Tielemans, with either Tielemans or Bruno Fernandes in the number 10 role.
A path toward justice and public safety
Strangulation can be one of the most dangerous forms of assault; despite the lack of visible ailments it is accompanied by. Though strangulation leaves no broken bones, bruises or visible wounds, it is one of the strongest predictors of future homicides for domestic violence victims. Until this year, second-degree assault by strangulation was not classified […]
2004-05 deja-vu - Can Moyes inspire another fine finish?
Deadline day may have left Everton fans feeling disillusioned, but the side is four games into the season and remains unbeaten, nine goals scored, including two in added time to secure a point. After what was a chaotic close to the transfer window, even by the Toffees' own standards, the performance against Manchester United ironically saw the summer signings playing a key role in the fight. Jack Grealish and Hayden Hackney came on from the bench to turn the game on its head, Tyrique George scored to equalise before the visitors went back in front, and it was Ainsley Maitland-Niles with a stunning strike to secure the draw in the final few seconds.
Draymond Green's Klay Thompson Defense Reveals Miami Heat's Promising Plan
Draymond Green's defense of Klay Thompson offers a useful blueprint for Miami Heat expectations. Thompson's role should center on shooting gravity, off-ball movement, and complementary offense-not recreating his 2017 Golden State Warriors production. Green's Ray Allen comparison reinforces that approach after Thompson's move to Miami. What Did Draymond Green Say About Klay Thompson and the […] The post Draymond Green's Klay Thompson Defense Reveals Miami Heat's Promising Plan appeared first on S
Entertainment District Around Akins Ford Arena Starts to Take Shape
Selling or leasing county-owned property around Akins Ford Arena has always been part of the plan for funding its construction, and the Athens-Clarke County Commission took another step toward that goal last week. The county is putting a parcel known as the Kelley Diversified tract on Willow Street up for sale. The old City of Athens bought the land and built a warehouse in 1970, and for a time it was used for vocational training. The unified government declared it surplus in 2007, but bids came in well below expectations, so it was never sold. However, since then the area between downtown and the North Oconee River has been built up, so the property could be more desirable to developers […]
Cleveland Clinic, RIKEN and IBM Team Advance to Finals for 2026 ACM Gordon Bell Prize
Joint research team modeled a 12,635-atom protein, the largest-known to be simulated using quantum computers. Breakthrough was achieved through quantum and classical methods working together, expanding quantum-centric supercomputing’s potential in life sciences research.
Guess Whose Back!? Dbacks 5, Royals 3. F/11
On Tuesday the Dbacks were able to get to a season high 10 games over .500 as they beat the Kansas City Royals in 11 innings. The story of the game was Corbin Burnes’ return to the team, but the guys that stole the show at the end were of an unlikely variety as there […]
Former Celtics Forward Finds New Team After Boston’s Roster Overhaul
A former Celtics forward has found a new team after Boston’s offseason overhaul left him without a clear role. The post Former Celtics Forward Finds New Team After Boston’s Roster Overhaul appeared first on HEAVY.
Volusia County business owner recovering after stabbing
Jessica and Count Foreman, co-owners of Saute Kingz in Daytona Beach, have temporarily closed their business following a violent incident involving their 23-year-old son, Jesshuan.
Five Plays: Ole Miss First Quarter
Louisville went down to Nashville and battled Ole Miss to the final second on the clock. There were a lot of questions that the Cards needed to answer quickly, with the main one being how Lincoln Kienholz would play in his first career start. But UofL came out with a great plan, and they took […]
Guardians Bounce Back With Gritty Win Over Orioles
The Cleveland Guardians stay on pace in the playoff hunt with an impressive win over the Baltimore Orioles.
Brandon Young bombs, Orioles fall to Guardians 9-5
The game was exciting for a few minutes in the middle.
Driveway of coastal mansion owned by Nicolas Cage collapses
The driveway of a coastal mansion in Malibu owned by actor Nicolas Cage has collapsed and opened a giant hole in front of the house.
Ray LaMontagne topples over onstage in Nashville, where the high hits 101
On Sept. 5, the 53-year-old folk singer fell while performing his popular track 'Jolene' in front of a sold-out Nashville show, according to fan footage.
Have we found alien life? Hundreds of scientists weigh in
Two major alien-life announcements in 2025 generated enormous excitement, but most astrobiologists remained unconvinced. Only 6.6% of surveyed experts thought possible biological molecules on K2-18b probably represented extraterrestrial life, while 15.1% said the same about intriguing mineral patterns in a Martian rock.
Cleveland Clinic, RIKEN and IBM Team Advance to Finals for 2026 ACM Gordon Bell Prize
Cleveland Clinic, RIKEN and IBM has been named as a finalist for the 2026 ACM Gordon Bell Prize for simulating the largest biologically meaningful molecules ever modeled with quantum computers, reaching a scale of 12,635 atoms.
Maryland Coach Mike Locksley Makes Little Slip to Kick Off UConn Week
UConn fans might come up with a chant out of the word "Toledo" before the Huskies and Terrapins meet Saturday.
Dodgers replace Shohei Ohtani with Freddie Freeman for Reds game
The Los Angeles Dodgers changed Freddie Freeman's role after an update on Shohei Ohtani.
LG TV shown capable of tracking user activity, even when offline
“It doesn’t cost a lot to store text forever.”...
Dolly Parton's sister slams 'fake AI garbage' following icon's death
In a Sept. 4 Instagram statement, Dolly Parton's sister Stella Parton thanked fans for the “genuine” support, urging supporters to use her sister’s life as an “example for tolerance and respect towards others.”
Orchard Place names Haselhuhn vice president of advancement
Orchard Place has named Adam Haselhuhn its new vice president of advancement, effective Sept. 14. Haselhuhn has more than 14 years of experience in higher education and healthcare philanthropy, most recently serving in senior development leadership roles at the John Stoddard Cancer Center and UnityPoint Health – Des Moines Foundation. He previously served as director…
AI’s Role in Health Care: What Keeps You Up at Night?
At the close of every The Buisness of Health episode, Charles N. Kahn III asks his guests the same question: ‘What keeps you up at night?’ In this highlights episode, Kahn shares intriguing responses on...
Fairfax Family Practice Centers selects new CEO
Fairfax County-based Fairfax Family Practice Centers has a new full-time CEO, with Frank Mencini beginning the role last week.
What Stands Out About Buccaneers' Week One Depth Chart?
The Tampa Bay Buccaneers' official depth chart had some surprises on each side of the ball. See which players have moved into starting roles ahead of Week 1.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Julia Stiles and her “DWTS” partner Ezra Sosa react to Juilliard’s ‘shady’ post referencing her “Save the Last Dance” character
The prestigious performing arts conservatory played a major role in the 2001 dance movie.
New GTA 6 NPC Details Revealed
A whole bunch of new NPC details for GTA 6 have been revealed, including behaviors, clothing, and more. Here are more details.
AI for better food safety: How tech helps uncover emerging outbreaks
Food-safety expert Willette M. Crawford discusses AI's role in preventing outbreaks and calling for recalls. She said regulatory challenges remain.
"The more he plays the better he gets": OU head coach Brent Venables on Cole Sullivan ahead of Michigan week
OU head coach Brent Venables and offensive coordinator Ben Arbuckle spoke to the media Tuesday following a dominant 51-0 victory over UTEP Friday night.
From science to screen time: 4 key takeaways from the latest PISA results
Amid reading declines that included a 14-point drop for the U.S., researchers are looking at the role digital learning and AI may have played.
Green Sports Alliance Names Jeff Pacini as New Executive Director
/PRNewswire/ -- Today, the Green Sports Alliance announced the appointment of Jeff Pacini as its new Executive Director. In this role, Pacini will steer the...
Bentley Awarded $235,000 to Strengthen Life Sciences Talent Pipeline
Bentley University will use $235,000 grant to prepare students for business roles in life sciences to meet Massachusetts workforce need.
Carole Radziwill says ‘the emotions all came back’ when “Love Story” aired while she filmed her return to “RHONY”
Radziwill is related to John F. Kennedy Jr. through marriage; her late husband, Anthony Radziwill, and JFK Jr. were first cousins.
Dallas police investigate small business break-ins in Bishop Arts District
Dallas police are investigating break-ins at multiple small businesses in the Bishop Arts District after suspects smashed doors and stole cash and items.
‘The View’ Hosts Miserably Fail Trivia About Their Experiences on the Show: ‘I Have No Idea What That Was’
The hosts of "The View" don't remember a whole lot of what they've done on the show over the years, and proved that on Tuesday
Smithsonian head Lonnie Bunch to retire amid Trump administration effort to reshape institution
Lonnie Bunch III said Tuesday that he will retire as the head of the Smithsonian Institution, a role that placed him at the center of President Donald Trump’s efforts to reshape the world’s largest museum organization.
Scientists find a huge 10-sided pattern in the clouds over Saturn's south pole
Scientists have discovered an enormous 10-sided wave pattern in the icy ammonia clouds over Saturn's south pole
Miami Heat's Davion Mitchell Eyeing the Most Improved Player Award
A cryptic beach message signals high ambitions for the Miami Heat’s starting point guard. Surrounded by superstars, Davion Mitchell aims to leverage his facilitating role into a career-defining season.
2026 Boolermaker Kids Race Registration Opens September 14
Kids can get ready for a spooky day of running and fun at the Boolermaker, which returns to T.R. Proctor Park.
Proposed Changes to Head Start Undermine Its Role in Promoting Child Nutrition and Healthy Eating - Food Research & Action Center
Published September 8, 2026 For more than 60 years, Head Start has supported young children during their most important phase of growth and development. For families with limited resources, Head Start is a trusted source of care, education, nutritious meals, and health services. Despite Head Start’s long history of bipartisan support, and demonstrated success, the U.S. Department of Health and Human Services (HHS) has a proposed new […]
David Kerr named GM of Mississippi Mud Monsters
PEARL, Miss. (WJTV) – The Mississippi Mud Monsters announced that David Kerr has been named General Manager of the organization after serving as Assistant General Manager since the club’s launch. Kerr was formally introduced in his new role during a news conference at Trustmark Park on September 8, 2026. “David has been right in the […]
How Orioles' Gunnar Henderson could land with Mets
Landing Henderson would be a very significant move for the Mets.
Trinity Health plans to lay off 500 information technology-related roles
New report finds little short-term health risk from air pollutants in South Portland, Portland
Six years of air sampling found benzene levels above state guidelines at one location and elevated acrolein levels across the study area.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Adley Rutschman's three-run HR off Pesky Pole carries Red Sox past Angels, 5-2
Adley Rutschman hit a three-run homer off the Pesky Pole in right field, Brayan Bello pitched five scoreless innings in his first start since early June and the hot-again Boston Red Sox beat the Los Angeles Angels 5-2 on Monday afternoon.
Online cybersecurity clinic available for Hawaiʻi small businesses
“The One-Person Security Department: Building Your Own Tools for Hawaiʻi IT on No Budget” is the topic for the first in a series of three free Zoom meetings presented by the University of Hawaiʻi Maui College for sole proprietors and registered businesses in Hawaiʻi.
Texas says 5th year OL Cole Hutson currently ineligible
Hutson sued the NCAA in Texas state court in July for an extra year of college eligibility after the NCAA announced a new plan for athletes to have five years once they enter college.
Javier Bardem, Penelope Cruz Tackle Politics at 'Bunker' Presser
Bardem's wife, Penelope Cruz, admitted she worries about the role of women today as the couple joined director Florian Zeller and co-stars Stephen Graham, Paul Dano and Paul Schwarzenegger ahead of the Venice premiere of 'Bunker.'
Health Column: Helping patients feel comfortable in their own skin
Content provided by Memorial Regional Health. When people think about dermatology, they often think about treating skin conditions like eczema, psoriasis, acne, or suspicious moles. But for Emma Rodgers, NP-C, dermatology is also about something...
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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