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Millie Bobby Brown gets 'secondhand ick' from 'Enola Holmes 3' costar Louis Partridge’s audition horror story

'So embarrassing!' Millie Bobby Brown gets 'secondhand ick' after hearing her 'Enola Holmes 3' costar Louis Partridge's audition horror story during a game of 'Lie vs. Lie' with 'Entertainment Weekly.'

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Jul 1 • 1:03 PM EDT • Entertainment • ew.com
New Federal Reserve Chair Warsh emphasizes political independence, signals focus on inflation

New Federal Reserve Chair Kevin Warsh said Wednesday that the central bank would remain independent and seek to bring down inflation, likely foreclosing the rate cuts President Donald Trump has sought. The Fed typically combats inflation by raising borrowing costs. When asked about Trump's oft-repeated desire for lower rates, Warsh underscored the Fed's independence from day-to-day politics.

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Jul 1 • 10:03 AM EDT • Politics • finance.yahoo.com
Only the midwest saw US population growth in every state. Will new residents change its politics?

Lower costs in Indiana, Iowa, Kentucky and Ohio raise questions about whether Republican strongholds will shift

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Jul 1 • 9:00 AM EDT • Politics • theguardian.com
Lawmakers takes another crack at easing privatization of youth sports

House bipartisan committee addresses private equity’s "vertical integration" that has youth sports costs soaring. What might come out of the hearing?

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Jul 1 • 9:00 AM EDT • Sports • usatoday.com
Sony will cease production of discs for new PlayStation games in 2028

New games sold for PlayStation consoles will only be available digitally and won’t be sold on discs effective January 2028, Sony has announced. The move applies to all PlayStation games released from that point on, including those made by Sony and those released by third parties. The PlayStation group calls the change “a natural direction for Sony Interactive Entertainment to adapt to consumer trends as the general preference for digital media significantly outpaces physical discs,” according to a PlayStation blog post reviewed by Game File in advance of its publication. As movies, TV and music have shifted from physical media to an age of downloads and streaming, Sony’s move could speed the demise of physical media in a gaming. The industry has offered consumers games via cartridges, cassettes, floppy discs, CDs, DVDs and Blu-Rays across a 50-year stretch. Sony has been reporting to investors in recent years that PlayStation games have been increasingly purchased as downloads, not as discs. The most recent figures show nearly four in five purchases of full games for PlayStation 4 and PlayStation 5 were purchased digitally in the past year. Stats like that may cause today’s news to carry an air of the inevitable. But Sony’s declaration for 2028 is still likely to produce a shock, as the biggest gaming platform on the planet that uses game discs leaves them behind. Discs going away, but the fate of game boxes is unknown Sony is committing to still selling games in physical retailers even after they drop discs in 2028. Just how those games will be sold—in boxes with codes inside, as cards marked with digital redemption codes—is unclear. Digital games will also continue to be sold in the online PlayStation Store. New games released for PlayStation consoles prior to January 2028 will be unaffected by the policy change, Sony says. That means the PS5 games of 2027, be they a new Madden, a new God of War, a new Call of Duty, a new Sly Cooper (one can dream?), would still potentially be offered on disc. PlayStation 6 implications Sony’s timeline for a transition to a no-disc era will also spin up more speculation about the timing and configuration of Sony’s next-generation console, the probable PlayStation 6. “This pretty much guarantees that PS6 won’t arrive until 2028 at the earliest,” Piers Harding-Rolls, senior games research analyst at Ampere Analysis tells Game File. Harding-Rolls also concludes from today’s news that “the base version of a PS6 will not include a physical media drive,” as Sony looks to keep costs down on the device. Sony itself is saying nothing about the PS6 today: not its timing, nor how it might or might not support internal or external disc drives in order to run disc-based PS4 and PS5 games, should the console be backwards compatible. The many signs this was coming Industry support for games being released on physical media has been waning. As has consumer interest in them. PC games effectively went all-digital years ago, thanks to the popularity of playing games through Steam and other digital storefronts. The Covid-19 pandemic and the lockdowns that kept much of the global population home helped shift shopping patterns toward downloads. Sony’s own data shows PlayStation game downloads being an uncommon consumer choice a decade ago and now becoming the norm. On consoles, physical media has been in such decline that Sony and Microsoft both launched their current gen Xbox Series and PS5 consoles in 2020 with cheaper versions that lacked disc drives. In early 2024, Phil Spencer, then head of Xbox, told me that ““[w]e ship games physically and digitally, and we’re really just following what the customers are doing.” He added that the game industry had become an outlier in still supporting disc-based entertainment, even as movies and TV have bailed on discs in favor of downloads and steaming: “Gaming consoles themselves have kind of become the last consumer electronic device that has a drive. And this is a real issue, just in terms of the number of manufacturers that are actually building drives and the cost associated with those. And when you think about cogs that we’re going to go put in a console—and as you have fewer suppliers and fewer buyers—the cost of the drive does have an impact.” Last year, the Nintendo’s Switch 2, which uses cartridges rather than discs, introduced the concept of game-key cards, which are physical media that contain no game, just a prompt for a download. Even disc-based games aren’t what they once were, now frequently containing just stubs of games rather than the whole thing. The website Does It Play has tested over 3000 games and found that, for example, that the disc version of this year’s hit 007: First Light, only contained the game’s first mission, with the rest needing to be downloaded. Beyond all that, last week brought the news that Grand Theft Auto VI, likely the biggest game launch this decade, will debut for PS5 and Xbox Series without a disc-based version. Today’s big news comes to you for free. Game File is a reader-supported publication. To receive new posts and ensure more of my work is possible, please consider becoming a free or paid subscriber. Subscribe Discs helped define PlayStation However the trends in entertainment may be going, it is still remarkable to see PlayStation ditch discs given their importance in PlayStation history: In the late 1990s, the first PlayStation’s support for games on relatively cheap CD-ROMs instead of traditional game cartridges allowed the upstart console to outmaneuver cartridge-based systems from Nintendo and Sega, as it drove down game prices down in the process. (The cheaper disc format even prompted Final Fantasy VII maker Square to taunt Nintendo in a magazine ad, saying that if the game was “available on cartridge, it’d retail for around $1200.”) PlayStation devices often doubled as machines for watching movies and TV on the latest disc-based formats. In the late 2000s, for example, Sony’s pricy PS3 gained traction as a go-to device for playing then-novel Blu-Ray discs. In 2013, Sony effectively roasted the digital game-sharing restrictions proposed by rival Microsoft for its upcoming Xbox One console by showing how games could be shared for the then-upcoming PS4. In a 21-second clip that has over 20 million views on YouTube, one PlayStation executive simply handed a game box—presumably with disc inside—to another, who said “thanks.” Sony’s possible motivations The PlayStation announcement today cites “consumer preferences” and a shift away from discs among “the broader entertainment industry,” but does not delve into the decision-making process that brought Sony to this point. Sony is not discussing the economics of this move (I asked!), but there are a number of potential factors: Abandoning discs will spare Sony the cost of manufacturing and shipping them, which analysts and industry veterans I spoke to said could account for $1 or so of a game’s retail price. For first-party games, that’s direct savings for Sony, though the amount is limited by the winnowing percentage of people who were even buying the disc-based versions. For third-party games, Sony could pass the savings on to partners or just retain the better profit margin for themselves. As the 2024 comments from Phil Spencer alluded to, leaving discs behind could mean leaving disc-drives behind, allowing Sony to produce consoles more cheaply. Switching to digital-only for games could diminish the risks of copies of new games leaking. It would also seemingly make second-hand sales of used games impossible, pushing more people to buy their own copies of games. These economic benefits for Sony could be boons for the games industry overall, Ampere analyst Piers Harding-Rolls tells Game File. Among other things, it could free publishers and retailers from having to worry about securing an inventory of game discs when trying to sell games, he noted. “If there is a way to streamline the business of games retail, I generally think it’s a good thing for the industry as it removes unnecessary costs,” Harding-Rolls said. “This will help offset pressure on margins from other directions – development and staffing costs for example.” Should the industry shift from game boxes that contain discs to smaller, cheaper game cards, Harding-Rolls said, that reduces pressure on publishers and retailers. “The advantage of everything going digital for the industry is that sales can be tracked much more easily and there is less commercial risk for publishers wanting to continue selling via retail,” he said. The shift to no discs will also likely impact game development timelines, as developers will no longer face the same urgency to have a build ready to submit to PlayStation for the production of a disc, as industry experts noted around GTA VI’s no-disc news last week. Instead, projects may gain weeks of development time, in the event delivery deadlines for platform approval move closer to release date. Preservationists’ likely worries While millions of gamers have shifted to digital, there are still people who associate game discs—and only game discs—with actual ownership of PlayStation games. That portion of the gaming community spoke up last week about wanting to buy a version of GTA VI that they could hold in their hands, could lend to a friend and could potentially pop into a well-preserved PS5 console three decades from now and still see it run. Such gamers didn’t want to worry that they’d merely purchased a digital copy that could lose access to the game if, say, the company behind the game someday turns of the servers that transmit downloadable copies. Digital copies of games are inherently less long-lasting, because consumers aren’t actually buying a game (on a disc), just buying access to the game. The fine print in online gaming shops notes this, as does a recent law that went on the books in California in 2025. That lasw requires game publishers doing business in the state to refrain from words like “sell” when offering digital copies of games, unless they explicitly tell consumers that what’s being sold isn’t the game itself but a potentially revocable license to access it. A Sony spokesperson noted to Game File that “[w]ith all digital content, including games, movies, and music, players are purchasing a personal license for non-commercial use.” Regarding the fears of PlayStation games being lost to time in an all-digital era, the rep also noted that Sony remains “committed to delivering experiences from past generations to the new platforms our players are using.” They noted that PlayStation has used emulation and remasters to keep offering its classic games to modern gamers. It’s true that many consumers have become accustomed to not having physical copies of new music albums or movies, but the relative precariousness of digital copies of games is in fact being highlighted today by…. Sony’s other big announcement: the upcoming closure of the PS3 and PS Vita online stores Sony said today that it will be closing the online marketplaces for its PlayStation 3 console and PS Vita handheld in most countries in July 2027 (sooner elsewhere: August 2026 for the PS3 store Mexico, Honduras and Nicaragua; late 2026 for PS3 in other Latin American countries and the Middle East). “We know this news may be disappointing to PS3 and PS Vita players who hold a special place in their hearts for this generation of gaming,” Sony said in its announcement, saying the move “was not an easy decision for us to make.” Sony said that PS3 and Vita marketplaces “are no longer able” to support modern commerce systems, prompting a “need” to close the shops and focus on more modern PlayStation platform stores. The news may spark some deja vu. Sony announced back in March 2021 that it planned to take the PS3, Vita and PlayStation Portable marketplaces offline that summer. The move would have caused some 2,000 digital-only games to become unavailable for new purchasers, according to a VGC analysis at the time. Fans complained loudly. By April 2021, Sony walked back the PS3 and Vita shop closures, with then PlayStation boss Jim Ryan saying “it’s clear that we made the wrong decision here.” This time around, Sony is giving a longer notice period in most regions. The closure of those stores is still likely to cut off access to new purchases of digital-only PS3 and Vita games. The current PlayStation 5 marketplace sells PS5 and PS4 games, as well as a selection of PS1 and PS2 games. It does not sell PS3 games, because games for that platform can’t run on the system (some are offered via a PlayStation Plus streaming option). Vita games also aren’t sold via PS5. Sony says digitally purchased PS3 and Vita games will be downloadable after the stores’ shutdowns “for the foreseeable future.” Sony’s move contrasts with Microsoft’s Xbox platform, which continues to sell and support games from all four Xbox console generations. But it puts it in line with Nintendo, which disabled purchases in the marketplace for its Wii console (a contemporary of the PS3) in 2019. Nintendo discontinued purchases in the online shop for its 3DS portable (a contemporary of the Vita) in 2023. The big questions about Sony’s 2028 post-disc era Will Microsoft follow suit, ending support for new disc-based games on Xbox platforms and therefore all game consoles, too? Whether Microsoft does or not, will third-parties that can no longer release games on discs for PlayStation, simply ditch the disc options across the board? Given the GTA VI no-disc experiment launching this November, will more game publishers decide to forgo disc-based offerings even in 2027? How will no-disc PS5/6 games be packaged and sold in brick-and-mortar retail stores? What becomes of game sharing in an all-digital era? Will Sony modify its current set-up, which currently allows some sharing of digital games across a pair of consoles, to allow more casual lending? (See for example, Nintendo’s year-old system of letting players lend a digital game to another player in a “family group” for up to 14 days.) Will there be a version of a PS6 with a disc drive? Or will a drive be offered as an add-on? And how will gamers who want to retain access to PS4/PS5 disc-based games react to whichever configurations Sony chooses to offer? What will the final disc-based PlayStation game be?

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Jul 1 • 8:00 AM EDT • Technology • gamefile.news
Virginia’s Styrofoam ban takes effect, Roanoke businesses face rising costs

Macado’s restaurants say the switch will cost more than $115,000 a year

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Jul 1 • 6:51 AM EDT • Business • wsls.com
AMC Entertainment (AMC) Is Down 8.7% After Equity Raise To Retire 2027 Notes And Fund Upgrades

In late June 2026, AMC Entertainment Holdings, Inc. completed a registered direct equity offering of about US$200.03 million and moved to fully redeem US$125.47 million of its 6.125% Senior Subordinated Notes due 2027 at par plus accrued interest. The company plans to use the remaining proceeds to bolster cash reserves and fund growth-oriented upgrades across its theatres as early as this autumn. Next, we’ll explore how using fresh equity capital to retire higher-cost debt and invest in...

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Jul 1 • 6:28 AM EDT • Entertainment • simplywall.st
Big Tech is spending billions to not employ people

Amazon disclosed $2.7 billion in estimated severance costs in its latest annual report, while Intel and Oracle also reported spending $1.8 billion.

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Jul 1 • 5:31 AM EDT • Business • businessinsider.com
Microsoft set to cut thousands of jobs next week, spanning Xbox, sales and consulting

Microsoft is preparing another round of layoffs, spanning Xbox, sales and consulting, as it holds down operating costs while pouring more than $100 billion into AI infrastructure.

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Jun 30 • 9:30 PM EDT • Technology • geekwire.com
Post From Community: ThriveOn King Small Business Loan Program returns for fourth round

The Greater Milwaukee Foundation is mobilizing another round of affordable loans to Milwaukee neighborhoods, with preference for disadvantaged businesses facing economic challenges due to rising costs and limited access to capital.

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Jun 30 • 6:10 PM EDT • Business • milwaukeenns.org
Program looks to help with cost of childcare in New York

Major counties are seeing multimillion-dollar boosts.

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Jun 30 • 5:26 PM EDT • Politics • spectrumlocalnews.com
Gov. Stein wants a study conducted on rising health care costs in NC, ways to make it affordable

The new commission will study rising health care costs in NC and recommend ways to make care more affordable.

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Jun 30 • 5:20 PM EDT • Health • abc11.com
Lawmakers Criticize Private Equity’s Influence in Youth Sports

A House hearing Tuesday probed private equity’s role in the rising cost of youth sports.

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Jun 30 • 5:12 PM EDT • Sports • wsj.com
Politics: High Cost Of Healthcare And The Political Fallout

Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.

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Jun 30 • 3:24 PM EDT • Health • npr.org
High-Signal Publisher
Politics: High Cost Of Healthcare And The Political Fallout

Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.

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Jun 30 • 3:24 PM EDT • Politics • npr.org
High-Signal Publisher
NC Gov. Stein tabs Treasurer Briner, Health Secretary Sangvai to lead probe of rising health costs

North Carolina has some of the fastest-rising healthcare costs in the country. Now, Treasurer Brad Briner, who oversees the State Health Plan, and DHHS Secretary Dev Sangvai will try to fix them.

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Jun 30 • 1:40 PM EDT • Health • wunc.org
Taylor Sheridan makes rare comment on Kevin Costner's departure from 'Yellowstone'

Taylor Sheridan is speaking out about Kevin Costner's departure from 'Yellowstone' in season 5, revealing that the actor had been 'ready to go.'

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Jun 30 • 1:22 PM EDT • Entertainment • ew.com
Stein creates bipartisan commission to address rising North Carolina health care costs

Gov. Josh Stein signed an executive order Tuesday creating a bipartisan commission to recommend ways to lower health care costs, improve transparency and expand access to care across North Carolina.

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Jun 30 • 12:05 PM EDT • Health • wral.com
Blake Lively is seeking $8.04 million in legal fees from Justin Baldoni amid 'It Ends With Us' settlement

Blake Lively is asking a judge to award her over $8 million in attorneys' fees and litigation costs for having defended herself against Justin Baldoni's now-dismissed defamation lawsuit.

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Jun 30 • 11:55 AM EDT • Entertainment • ew.com
Millions drop Obamacare health coverage after subsidies expire and costs rise

Experts share why millions of people lost their Affordable Care Act health insurance plans this year after federal subsidies expired.

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Jun 30 • 11:05 AM EDT • Health • abc7.com
Millions drop Obamacare health coverage after subsidies expire and costs rise

Experts share why millions of people lost their Affordable Care Act health insurance plans this year after federal subsidies expired.

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Jun 30 • 11:05 AM EDT • Health • 6abc.com
PlayStation PC Retreat Is A Mistake, As 18+ Months Late Ports Made Money Without Costing a Single Console Sale

Shawn Layden argues PlayStation’s PC port retreat is a mistake, proving late ports made cash without dropping PS5 sales

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Jun 30 • 11:03 AM EDT • Technology • wccftech.com
Business is good at the Camillus Costco. It asks town for OK to make a move

The proposal is being reviewed by the town of Camillus planning board.

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Jun 30 • 9:00 AM EDT • Business • syracuse.com
No more selling PlayStation hardware at "significant" loss, says Sony, as everyone braces for a PS6 console that costs over $1,000

Sony is seemingly no longer interested in subsidising the cost of its hardware to reduce the price for the end user.

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Jun 30 • 7:10 AM EDT • Technology • eurogamer.net
China's Xiaomi, Oppo, Vivo cut 2026 smartphone targets again: sources

Rising costs and component shortages lead some brands to slash outlook by up to 30%

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Jun 29 • 11:09 PM EDT • Technology • asia.nikkei.com
ERISA’s Important but Limited Role in Health Care Cost Containment

Executive Summary Rising health care costs have brought renewed attention to the Employee Retirement Income Security Act of 1974 (ERISA) as policymakers and advocates look for new ways to address increasingly expensive employer-sponsored coverage. Leveraging requirements under ERISA appears attractive because other cost-containment efforts have had limited success, making the statute seem like a potential […]

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Jun 29 • 8:00 PM EDT • Health • americanactionforum.org
Olivia Wilde says Walton Goggins 'saved my life' after horse accident

Olivia Wilde recalled the moment her "Cowboys & Aliens" costar Walton Goggins "saved my life" after a horse accident on the set of the 2011 sci-fi Western. "I've ridden horses

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Jun 29 • 7:34 PM EDT • Entertainment • centraloregondaily.com
Cara Delevingne confirms she and Amber Heard were romantically involved amid actress' Johnny Depp divorce

Model-actress Cara Delevingne confirms she and 'London Fields' costar Amber Heard were romantically involved amid actress' divorce from Johnny Depp.

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Jun 29 • 7:03 PM EDT • Entertainment • ew.com
Henry Winkler says 'there's a string between' him and his 'Happy Days' costar Ron Howard

Winkler and Howard costarred on the '70s sitcom, and they've remained close in the decades since.

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Jun 29 • 6:41 PM EDT • Entertainment • ew.com
BlueCross BlueShield of VT pulls its proposed lower-cost, higher-deductible health plans

The insurer said the Green Mountain Care Board’s delayed approval of the plans left them with little time to prepare.

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Jun 29 • 5:59 PM EDT • Health • vtdigger.org
Scott Eastwood recalls entitled costar who exited movie mid-production: 'Don't be a piece of s---'

Scott Eastwood recently looked back on working with an entitled costar who abruptly left a movie while production was underway.

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Jun 29 • 5:08 PM EDT • Entertainment • ew.com
Cost and utilization of inpatient mental health and substance use treatment - Peterson-KFF Health System Tracker

Approximately 1 in 5 people with private health insurance have any mental illness, and 1 in 20 have a serious mental illness. This brief examines inpatient mental health and substance use treatment admissions in 2023 among adults aged 18-64 with large employer-sponsored health insurance plans. Private insurance enrollees constitute roughly a quarter (26%) of mental […]

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Jun 29 • 4:34 PM EDT • Health • healthsystemtracker.org
Trump voters say costs are crushing their wallets — but look past president for blame

Trump rally attendees say rising gas prices are linked to the Iran conflict, not Trump's policies, and express confidence costs will decline soon.

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Jun 29 • 1:16 PM EDT • Politics • foxnews.com
Unredacted comments from California hospital lawsuits show stunning admissions and a 'forced' McKinsey collaboration

Who controls the Medicaid market, GLP-1 usage and pizza household costs, and more from Health Care Inc.

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Jun 29 • 1:03 PM EDT • Health • statnews.com
About 3 million people have dropped Obamacare health coverage after subsidies expire and costs rise

The Department of Health and Human Services suggests the 13% drop is due to a federal crackdown on fraudulent enrollmentut, but health analysts believe it's more likely related to the Jan. 1 expiration of federal subsidies.

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Jun 29 • 12:12 PM EDT • Health • pbs.org
We’re still writing p3ri0d

What algorithmic suppression of women’s health content is actually costing us.

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Jun 29 • 9:28 AM EDT • Health • fastcompany.com
A $1000 PlayStation 6 No Longer Sounds Crazy, As Sony Doesn’t Intend To Sell Hardware At Significant Losses

The PlayStation 6 is set to launch at one of the most challenging times for consumer tech, if not the most challenging. With the rising prices of components, RAM and SSDs above all, manufacturers are having an extremely hard time keeping costs down, and with a bill of materials that is now close to $1000, there's a very high chance the system will cost way more than most anticipated. Adding fuel to the fires of speculation is Sony itself, as the company heavily suggested in a recent investor Q&A session that it won't heavily subsidize the system. "We regard hardware as the base […]

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Jun 29 • 7:40 AM EDT • Technology • wccftech.com
Medicare is about to cover GLP-1 drugs for weight loss. Here’s what to know.

The Trump administration will launch its pilot program on Wednesday. It lasts 18 months, and estimated costs to taxpayers have not been disclosed.

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Jun 29 • 6:00 AM EDT • Health • washingtonpost.com
iPhone 18e Won't Get ProMotion Display, Says Leaker

Apple's upcoming iPhone 18e will have the same display refresh rate as the existing iPhone 17e, according to a prominent Chinese leaker. Discussing Apple's product plans for 2027 in a Weibo post, Digital Chat Station claimed that the next generation of Apple's low-cost iPhone will feature the same 60Hz low-temperature polycrystalline silicon (LTPS) TFT panel as the current model.

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Jun 29 • 5:54 AM EDT • Technology • macrumors.com
It looks like PlayStation 6 is going to cost Sony about $1,000 to make, which likely means it will cost more than that at retail

The cost to make a single unit of the PlayStation 6 has gone up, according to new information from a reliable insider.

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Jun 29 • 5:24 AM EDT • Technology • eurogamer.net
Millions drop Obamacare health coverage after subsidies expire and costs rise

Health analysts say the drop in enrollment was likely related to the Jan. 1 expiration of federal subsidies, which caused a surge in plan costs that resulted in many people being unable to pay their premiums.

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Jun 29 • 2:04 AM EDT • Health • ms.now
Experts bet World Cup wagers will bring Mass. big tax revenue

Experts say the tournament is on pace to be the biggest sports betting event in history, bringing new revenue to the state. But some fear it carries public health costs, too.

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Jun 29 • 1:48 AM EDT • Health • wbur.org
Experts bet World Cup wagers will bring Mass. big tax revenue

Experts say the tournament is on pace to be the biggest sports betting event in history, bringing new revenue to the state. But some fear it carries public health costs, too.

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Jun 29 • 1:48 AM EDT • Sports • wbur.org
PS6 Hardware Cost Estimated at $900+

The upcoming Sony PlayStation 6 is slated to launch sometime in 2028, and with recent reports claiming that the ongoing RAM crisis likely won't end or ease up much before then, concerns are mounting about the price of next-gen gaming consoles. Those concerns are seemingly justified, with ubiquitous ...

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Jun 29 • 1:08 AM EDT • Technology • techpowerup.com
Millions drop Obamacare health coverage after subsidies expire and costs rise

Hampton Roads Virginia and Northeastern North Carolina News, Weather, Traffic and Sports.

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Jun 28 • 9:05 PM EDT • Health • wavy.com
Couple retired to Costa Rica with 2 sons; bought a $1.6 million house

"We fill every day. There's really not a lot of downtime, yet we never feel rushed or pushed or stressed," Andrew Rappaport told BI about life in Costa Rica.

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Jun 28 • 7:14 PM EDT • Business • businessinsider.com
AI could unleash ‘single greatest productivity revolution’ if Washington avoids overreach: report

The Unleash Prosperity report, titled "Boomsday Not Doomsday," argues AI could help ease housing costs, boost productivity and move workers into higher-value roles.

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Jun 28 • 6:34 PM EDT • Business • foxbusiness.com
Being broke costs you 13 IQ points, according to science. Here's the number that changes everything.

CreditNinja reports that saving your first $10,000 unlocks financial stability, improving decision-making and reducing stress, ultimately boosting cognitive function.

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Jun 28 • 6:00 PM EDT • Science • wxow.com
Suspicious Steam Machine clone from China costs just $688, has a Ryzen 5 5500 with an RX 6750 GRE GPU

A Chinese listing shows a Steam Machine clone with an RX 6750 GRE for $688, but spec errors and pricing math make this listing look very suspicious.

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Jun 28 • 5:45 PM EDT • Technology • tweaktown.com
Entertainment Firms Face AI Copyright Uncertainty

Editorial analysis: For AI and ML practitioners, unclear copyright rules raise the legal risk and compliance cost of using generative models in production content pipelines. According to The Economic Times, Indian entertainment firms are investing heavily in AI for content creation, but current copyright law, which is tied to human creativity, may not clearly protect AI-assisted or AI-generated works. The Economic Times reports lawyers warn that, without specific legislation or case law, such works face risks of duplication and misuse, complicating licensing, attribution, and monetization for studios and creators. The article highlights that creators and rights holders in India currently have limited legal recourse under existing statutes, per The Economic Times.

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Jun 28 • 2:57 PM EDT • Entertainment • letsdatascience.com
College Sports Roster Spending Soars Beyond $20.5M Rev-Share Cap

The $20.5 million rev-share cap was a new floor for roster costs.

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Jun 28 • 2:52 PM EDT • Sports • sports.yahoo.com
Seattle's data center moratorium: symbolic politics, real costs

With its data center moratorium, Seattle just put the whole city on the wrong side of the new digital divide — and its poorest residents will feel it most.

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Jun 28 • 11:00 AM EDT • Politics • seattletimes.com
El Niño Is Back—and It Could Cost Businesses Trillions. What Smart Leaders Are to Prepare

Dartmouth research makes the duration of the damage clear: economic losses from major El Niño events persist for five years after the event itself.

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Jun 28 • 10:34 AM EDT • Business • inc.com
Huntsville health department hosting no-cost prostate exams

Prostate cancer can be treated and cured with early screenings, according to Dr. Thomas Moody with the Urology Health Foundation.

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Jun 28 • 8:30 AM EDT • Health • al.com
The PlayStation 6 Reportedly Already Costs $960 in Materials to Manufacture

The PlayStation 6 reportedly costs $960 to build in materials, suggesting next-gen consoles' prices could be much higher than anticipated.

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Jun 28 • 7:58 AM EDT • Technology • insider-gaming.com
My 2 sons moved back in with me; my expenses have gone up

My two sons still live with me so they can save on housing costs. That means my expenses have gone up, like electricity and grocery budgets.

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Jun 28 • 7:07 AM EDT • Business • businessinsider.com
Texas Mental Health Program Reveals 103% Increase in Veteran Enrollment

Emory University treatment is expanding throughout the state at no cost, but many veterans remain unaware of their services.

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Jun 28 • 6:00 AM EDT • Health • military.com
Costs of Iran war will linger despite conflict's end, experts say

The effects of the war and other factors driving inflation are likely to stick around for months, experts say, presenting an ongoing challenge to American households.

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Jun 28 • 6:00 AM EDT • Politics • latimes.com
Patients can save thousands with drug coupons, but only if insurers honor them

Patients who rely on co-pay assistance from drugmakers are typically heavy users of health care for whom delays in treatment or worsening conditions can lead to higher costs, according to patient advocates.

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Jun 28 • 5:00 AM EDT • Health • washingtonpost.com
Business People

Northwest Arkansas-based CS Bank has recognized its Chairman of the Board, John Fuller Cross, for reaching 70 years in the banking industry.

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Jun 28 • 3:43 AM EDT • Business • nwaonline.com
Business People

Northwest Arkansas-based CS Bank has recognized its Chairman of the Board, John Fuller Cross, for reaching 70 years in the banking industry.

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Jun 28 • 3:43 AM EDT • Business • arkansasonline.com
Business People

Northwest Arkansas-based CS Bank has recognized its Chairman of the Board, John Fuller Cross, for reaching 70 years in the banking industry.

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Jun 28 • 3:43 AM EDT • Business • nwaonline.com
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US Oilfield Business Activity Strengthens, Though Oil Price Uncertainty Remains

The Federal Reserve Bank of Dallas’ second-quarter energy survey reports improved business conditions, despite a mixed outlook on oil prices and input costs.

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Jun 28 • 1:01 AM EDT • Business • jpt.spe.org
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MS Comic Con 2026: cosplayers, celebrities and fans unite to celebrate beloved characters

Attendees decked out in costumes and homemade props from their favorite TV shows and movies gathered at the Mississippi Trade Mart for Comic Con 2026

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Jun 27 • 9:31 PM EDT • Entertainment • clarionledger.com
States seek to lower drug prices by targeting the companies that manage them for health plans

TOPEKA, Kan. — As consumers worry about medication costs, states are trying to lower drug prices by reining in big companies that oversee prescription coverage for health insurers. Some of those companies, called pharmacy benefit managers, also own pharmacies, and one of them, CVS, has spent millions of dollars fighting

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Jun 27 • 5:52 PM EDT • Health • triblive.com
Millions drop Obamacare health coverage after subsidies expire and costs rise

NEW YORK — About 3 million fewer people in the United States had Affordable Care Act health insurance plans in February compared with the same time...

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Jun 27 • 2:39 PM EDT • Health • post-gazette.com
The sky is not falling. Americans are getting healthier.

Despite declining obesity and heart disease rates, increasing cancer survival rates, and a record high life expectancy, politicians from both parties are pushing costly and ineffective policies to …

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Jun 27 • 2:00 PM EDT • Politics • thehill.com
Millions drop Obamacare health coverage after subsidies expire and costs rise

About 3 million fewer people in the United States had Affordable Care Act health insurance plans in February compared with the same time last year, according to new federal data. In the report releas...

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Jun 27 • 1:51 PM EDT • Health • yahoo.com
Millions drop Obamacare health plans after subsidies expire and costs rise

New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year.

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Jun 27 • 1:51 PM EDT • Health • apnews.com
High-Signal Publisher
Millions drop Obamacare health coverage after subsidies expire and costs rise

New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year. The Department of Health and Human Services...

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Jun 27 • 1:51 PM EDT • Health • bigrapidsnews.com
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Millions drop Obamacare coverage after subsidies expire, costs rise

New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year

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Jun 27 • 1:51 PM EDT • Health • abcnews.com
Don't break the tech tools small businesses use to compete

Forcing companies to split up their integrated services would increase costs and headaches for businesses like mine, writes Andrea Ramker.

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Jun 27 • 11:21 AM EDT • Business • desmoinesregister.com
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5 million have dropped ACA insurance after Trump and the GOP let prices skyrocket

The number of people who signed up for a health plan and then didn't pay their premium fell much more sharply than it has in years past. Trump officials blame fraud. Health policy experts blame costs.

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Jun 27 • 10:24 AM EDT • Health • npr.org
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Central NY farm in business for more than 80 years faces costly rebuild after fire

Community members and farmers have rallied to help the farm cleanup and rebuild after a fire destroyed its greenhouses.

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Jun 27 • 9:00 AM EDT • Business • syracuse.com
The Most Expensive AC Setting to Use During a Heat Wave, Experts Say

Trying to stay cool during a heat wave? Experts reveal the AC setting that can drive up energy costs the most—and what to use instead to save money.

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Jun 27 • 8:00 AM EDT • Technology • marthastewart.com
California health insurance tax hike: Will your premiums increase?

A balance act: To help fund the safety net, lawmakers have voted through a health tax extension that could increase premium costs for Californians with private insurance.

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Jun 27 • 6:00 AM EDT • Health • latimes.com
Trump-endorsed candidates hold nearly perfect record in GOP primaries

No modern president wields party influence the way Donald Trump does, experts say, but it could be costly to his party in the 2026 midterms.

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Jun 27 • 3:01 AM EDT • Politics • usatoday.com
Businesses across Oahu prepare to close as rising costs strain operations

Community members say the closures are difficult to watch, especially as familiar businesses continue to disappear across the island.

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Jun 27 • 12:35 AM EDT • Business • hawaiinewsnow.com
States seek to lower drug prices by targeting the companies that manage them for health plans

Legislators across the U.S. are trying to lower prescription costs by reining in big companies that handle drug coverage for health insurers.

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Jun 27 • 12:10 AM EDT • Health • seattletimes.com
States seek to lower drug prices by targeting the companies that manage them for health plans

Legislators across the U.S. are trying to lower prescription costs by reining in big companies that handle drug coverage for health insurers.

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Jun 27 • 12:06 AM EDT • Health • click2houston.com
Applications open for Hawaii County Kona low business recovery program

Eligible businesses can use the money for recovery needs, including equipment repair, temporary relocation costs and water damage.

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Jun 26 • 10:54 PM EDT • Business • hawaiinewsnow.com
😐 Neutral (0%)
Applications open for Hawaii County Kona low business recovery program

The reward from the county can be used for recovery needs, including equipment repair, temporary relocation costs and water damage.

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Jun 26 • 9:51 PM EDT • Business • hawaiinewsnow.com
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Healthcare AI Leaders Are Rapidly Trying To Outmaneuver Skyrocketing Memory And GPU Costs

Compute power has become one of the most crucial components of the healthcare delivery cycle.

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Jun 26 • 8:00 PM EDT • Health • forbes.com
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Senators call for military healthcare program to cover autism therapy as a basic benefit

A letter to Defense Secretary Pete Hegseth follows an NBC News investigation into the military healthcare program’s restrictions on applied behavioral therapy.

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Jun 26 • 5:26 PM EDT • Health • nbcnews.com
High-Signal Publisher
Roy Cooper brings 'Make Stuff Cost Less' tour to Asheville, targets health costs, tariffs

Former North Carolina Governor and U.S. Senate candidate Roy Cooper brought his "Make Stuff Cost Less" tour to Asheville on Friday.

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Jun 26 • 3:46 PM EDT • Health • wlos.com
Axios Live: Health care affordability emerges as a defining issue

Concerns about health care costs are motivating voters across the ideological spectrum

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Jun 26 • 3:19 PM EDT • Health • axios.com
High-Signal Publisher
Essentia again ranks among Minnesota's best for quality care

Minnesota Community Measurement (MNCM) — a statewide resource providing timely, comparable information on healthcare quality, costs and equity — once again ranks Essentia Health as a quality leader in its annual Health Care Quality Report.

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Jun 26 • 2:35 PM EDT • Health • essentiahealth.org
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Axios Live: "Health care costs are scaring people," Rep. Dingell says

Americans are not just thinking about the high prices of health care — they're afraid of them

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Jun 26 • 1:45 PM EDT • Health • axios.com
High-Signal Publisher
Xbox Sales Are Its Lowest Ever This Month, PlayStation Its Lowest Since 2000

Xbox and PS5 sales have cratered due to skyrocketing prices based on skyrocketing component costs they have to pay.

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Jun 26 • 10:51 AM EDT • Technology • forbes.com
NASA's canceled Artemis hardware contracts reached $5.9 billion, audit finds

NASA was on track to pay nearly half a billion dollars for a stage adapter. A stage adapter should not cost half a billion dollars.

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Jun 26 • 9:00 AM EDT • Technology • space.com
Cutting costs to move forward: SoFi State of Small business 2026 survey

SoFi reports 86% of small business owners see growth or stability, yet 66% cite high costs, mainly inflation and interest rates, as major challenges.

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Jun 26 • 8:00 AM EDT • Business • miamiherald.com
Cutting costs to move forward: SoFi State of Small business 2026 survey

SoFi reports 86% of small business owners see growth or stability, yet 66% cite high costs, mainly inflation and interest rates, as major challenges.

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Jun 26 • 8:00 AM EDT • Business • tri-cityherald.com
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system

WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.

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Jun 26 • 8:00 AM EDT • Health • who.int
NC Democrats demand lower utility costs + budget talks drag on as deadline nears

Read our Under the Dome newsletter and listen to our Under the Dome podcast to stay up to date on #ncpol.

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Jun 26 • 6:30 AM EDT • Politics • newsobserver.com
Bayer wins in US court, but at what cost to public health?

A landmark US Supreme Court ruling protects Bayer from thousands of lawsuits linked to its Roundup weedkiller. Plaintiffs alleged the German agrochemical giant failed to warn users about potential cancer risks.

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Jun 26 • 6:21 AM EDT • Health • dw.com
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Strategy Of Employing AI Mental Health Chatbots As School Psych Counselors For Teens

Teens increasingly have mental health issues, schools are trying to keep up. School psychologists are costly. LLMs can be an amplifier as a tool. An AI Insider scoop.

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Jun 26 • 3:15 AM EDT • Health • forbes.com
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Mark Cuban urged AI firms to spend billions on cities hit by job losses

He said this is the "cost of doing business" for the companies that are losing a PR battle with the masses.

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Jun 26 • 12:18 AM EDT • Business • businessinsider.com
🙂 Positive (50%)
It's Xbox's turn (again), as console prices keep going up

Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.

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Jun 25 • 8:21 PM EDT • Technology • gamefile.news
Making Our Own Luck

We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.

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Jun 25 • 4:48 PM EDT • Science • goodscience.substack.com
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This Week in Jacksonville: Business Edition - Tim Cost reflects on 14 years leading Jacksonville University

As Jacksonville University prepares to welcome new leadership, outgoing President Tim Cost says his focus remains on the institution’s future rather than his own legacy.

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Jun 25 • 2:19 PM EDT • Business • news4jax.com