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Brad Pitt's Underrated Sci-Fi Astronaut Movie Deserved Better At The Box Office
You likely missed this critically acclaimed Brad Pitt sci-fi thriller when it was in theaters, but it's a film that warrants a watch.
Liverpool working towards deal for star; could reach €90m
Liverpool are reportedly in the mix for a very in-demand France star. They’re working towards a deal and it’s one that could cost €90m.Liverpool are weighing up their transfer targets for the up...
Cavs vs. Timberwolves: How to watch, odds, and injury report
The Cavs will welcome the surging Timberwolves to town.
How Pratt Proved Brewers Right in the World Series
Shrugging off an early error, rookie Cooper Pratt delivered a clutch game-winning hit, vindicating the Milwaukee Brewers long-term investment.
NH candidates for governor, U.S. Senate, Congress clash over...
At a Manchester forum, New Hampshire candidates clashed over housing, energy, healthcare and other costs as affordability emerged as voters’ central concern. ...
Michigan basketball gets reality check in exhibition loss vs Houston
Michigan writer Tony Garcia offers three observations from the Wolverines' 83-66 loss to Houston in its final exhibition.
Primark's Business Doesn't Make Sense
In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot
Zen Browser is the Arc replacement I was looking for
Zen rips off all the best bits of Arc, but skips the AI and bloat.
The Politics of Heaven ~ The Imaginative Conservative
The key to understanding Thomas More’s generous dedication to the real but limited good he could do on earth is, as Frank Mitjans makes clear, that More’s constant contemplation of God was the source of his boundless care for the souls surrounding him. Thomas More’s Vocation, by Frank Mitjans
Why is the U.S. accusing Canada of election interference?
the U.S. Embassy accused Canadian officials of meeting with Democratic lawmakers, urging the use of retaliatory levies to hit Republican states, and running anti-tariff political advertising.
‘Masterplan’: Too lightweight to make an impact
Pretty faces can’t overcome ho-hum plotting
USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again
Both the USC Trojans and the UCLA Bruins had their rankings in the Associated Press Top 25 poll following their results from Saturday. View this post on Instagram A post shared by LA Sports Report (@lasportsreport) What Happened to USC’s Ranking? Following their loss to Wisconsin on Saturday, USC dropped out of the Top 25. […] The post USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again appeared first on LA Sports Report.
Sky Sports share rumours of unhappy Leeds United star live on air vs Sunderland
Daniel Farke looking unimpressed as Leeds United take on Sunderland at Stadium of Light on 25 October
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center
The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.
Ravens lose standout rookie to injury against Bengals
The Baltimore Ravens have lost a key rookie to injury, forcing another change up front against the Cincinnati Bengals.
How to watch the 2026 WNBA Finals: Golden State Valkyries vs. Atlanta Dream Game 5 time, schedule, where to stream and more
Gina Hinojosa says there's "deep disappointment in both political parties" in Texas right now
Cardinals Week 7 inactives
Cardinals announce seven inactives ahead of Week 7 game
Queen of Halloween Heidi Klum teases costume with mysterious image
“What’s my costume?,” the model asked fans alongside a strange close-up photo.
Three Premier League talking points
Michael Carrick was pushed to the brink of the sack by Manchester United's latest debacle on Sunday.AFP Sport looks at three talking points from the weekend's action: Walls closing in on Carrick Michael Carrick's future as Manchester United boss was already hanging by a thread before Bournemouth inflicted what is likely to be a brutal last act for the former England midfielder at Old Trafford.
‘I love spending time with them’: Lewis Hamilton opens up about Kim Kardashian’s kids
Lewis Hamilton and Kim Kardashian have been one of the most talked-about couples in sports and entertainment this year, but the seven-time Formula 1 world champion has rarely said much about the relat...
Nigeria widens hunt for possible Ebola cases
Nigeria has widened a hunt for potential Ebola cases, with an additional nine contacts traced, health authorities said Sunday.The initial 44 contacts were health care workers, while the additional nin...
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race
Blanche told CNN's “State of the Union” that President Donald Trump, who said Friday that he was "the one that said do it,” is not trying to overturn state election results “in any way, shape or form” on the cusp of the Nov. 3 election.
Windows 11 is apparently so bad that XBOX would rather cancel hardware than be forced to use the OS
A reported clash between Microsoft's XBOX and Windows teams suggests Windows 11's desktop may no longer be the foundation for Project Helix.
Ramaswamy built his political career in NH. It's faltering in Ohio.
Many New Englanders remember Ramaswamy from his mad-dash presidential campaign in New Hampshire. Will his political career survive a tumultuous run for Ohio governor?
The Times' top 25 high school football rankings
A look at the top 25 high school football teams in the Southland after Week 9.
Navigating D1 pressure: how student-athletes balance their mental health
Mental health affects everyone, including athletes who have a really good way of hiding it. Research shows that mental health issues affect roughly 39-44% of Division I athletes. Behind game day, good game performance, and navigating life in college, D1 athletes are constantly trying to balance high expectations with their own well-being. It’s not...
Detectives seek information about business conducted with Piedmont Memorial Park Cemetery
Detectives are seeking information from anyone who has conducted business involving the cemetery since January 2019.
Blanche defends DOJ lawsuit blocking Alaska Senate results if Republican loses
Attorney General Todd Blanche defended the Justice Department's suit over Alaska's Senate race in an interview on CNN.
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine
Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria contracted Ebola.
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine
Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria cont...
Three receptions for Germie Bernard
Steelers WR Germie Bernard catches three of his five targets in Week 7 win
Professor Katherine McNeill Inducted Into Massachusetts Science Educators Hall of Fame
Katherine L. McNeill was inducted into the Massachusetts Science Educators Hall of Fame on Friday in recognition of her two decades of work in science education.
Schefter: Seahawks among teams ‘expected to consider’ Jonathan Taylor trade
The Seahawks are “pondering” adding Taylor in hopes of saving their run game.
Projections for Cleveland Guardians’ Arbitration Eligible Players
The Cleveland Guardians have several key players arbitration-eligible this offseason.
‘Clayface’ Ties ‘Obsession’ For A Rotten Tomatoes Audience Score Record
'Clayface' has a Rotten Tomatoes audience score that matches Obsession's a wild achievement for the comic book film.
Union County Best of the Best Business of the Year Magnolia Renovations Joshua Andrews, owner
What was your reaction when you learned your business had been named Business of the Year?
Steelers Now Postgame: Steelers 16, Saints 10
Pittsburgh Steelers Postgame: Join Alan Saunders and Jobe Morrison after the Steelers’ Week 7 win over the Saints on YouTube, […]
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1
NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...
Lady Gaga dancer reveals why he thinks she’ll succeed at motherhood
Lady Gaga’s backup dancer, who slid off stage mid-performance during last year’s Mayhem Ball world tour, is opening up about why he believes the singer will succeed at motherhood.
How Argentina’s Folk Sounds Are Shaping a Generation’s Politics and National Pride
Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside, staving off pop homogenization and sharing their history with the world
What are you reading this week?
Our reading list never stops growing, but this week we're digging into buzzy literary thriller Fruit Fly and a sweet paranormal romance.
NFL Week 7 Sunday afternoon open thread
Join us at Buffalo Rumblings as we chat all things NFL Week 7 LIVE with like-minded folks in Bills Mafia
Oregon fires offensive coordinator Drew Mehringer after team scored just 10 points in loss to Illinois
Saturday's loss marked the third straight game in which Oregon scored under 20 points.
Blanche says Trump isn’t trying to meddle with Alaska election results by suing over Senate race
WASHINGTON (AP) — Attorney General Todd Blanche on Sunday defended the Trump administration's lawsuit to block certification of Alaska's Senate results if Repub
Aaron Rodgers throws for 212 yards in Week 7
Steelers QB Aaron Rodgers sees multiple TD streak snapped in Week 7 win
Warren, Steelers stiff-arm Saints for 16-10 Paris win
Jaylen Warren had another big day and the Pittsburgh Steelers overcame some red-zone inefficiency to beat the New Orleans Saints.
Saints Lose Defensive Battle in Paris Against Steelers
A very winnable game that a better team would have won.
Sunday Puzzle: BRB
NPR's Ayesha Rascoe plays the puzzle along with Weekend Edition Puzzlemaster Will Shortz and WUOT listener Jordan Bogdan of Oak Ridge, Tennessee.
Browns injury update: Is Denzel Ward playing against the Titans?
The Browns will enjoy the presence of their top cornerback in Week 7.
Kansas at Duke: Exhibition OGT
Kansas basketball hopes to follow the football team with a win today. Yeah, this game doesn’t count, but any time you’re playing Duke you want to win. Plus, this exhibition game is a big enough deal that ESPN is broadcasting it live (probably because they know everyone else will be watching football. I’m probably going […]
One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie
Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.
Kings' Veterans Praise Rookie Acuff After 33-Point Showing
The Sacramento Kings are yet to get a win, but Darius Acuff Jr. looks like the high-octane guard that the franchise so desperately needs. Coming off a 33-point outburst, how will Acuff play against the Memphis Grizzlies?
Texas opens as heavy favorite against Mississippi State
The Longhorns are three-score favorite as they welcome the Bulldogs to Austin.
3 comments | Progressive Democrats are closely watching four Senate...
Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.
Is having urine the color of Mountain Dew normal?
A Trump administration doctor says neon yellow urine is normal because of diets consisting entirely of meat and fermented foods. Here’s what experts say
Browns Week 7 inactives: Who's in, who's out?
The Browns are the healthiest they have been in some time as they take on the Titans in Week 7.
Chivu: “The boys gave everything right to the end”
Cristian Chivu wasn't the only one who couldn't bear to watch Zielinski's decisive penalty. The Inter coach bent over on the touchline, looking away as the midfielder stepped up to take it. When the b...
How Braves should handle $42 million Jurickson Profar situation
This could be one solution for the Braves.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Texas Tech Leads 'Bad' Week 8 for Big 12 Unbeatens
The Red Raiders’ playoff dreams hit a wall in Cincinnati as sloppy play and missed opportunities ended their unbeaten run. The Big 12 race is now more open than ever after surprising finishes elsewhere.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
During the hike, participants wore military short-shorts known as “silkies” as part of the event’s tradition to foster connection.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Senator, former California Secretary of State Alex Padilla weighs in on voter roll fight
With one week left before the midterm elections, California is facing a federal lawsuit alleging that non-citizens were registered to vote, received mail-in ballots, and, in some cases, voted.
South Texas Health System (@stxhealthsystem)
1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".
Cam Skattebo Update: Will Giants Star RB Play Against Texans?
New York Giants share news on RB Cam Skattebo after benching in Week 6. The post Cam Skattebo Update: Will Giants Star RB Play Against Texans? appeared first on HEAVY.
Robinson, Baker have tough talk about the offense
Robinson, Baker have tough talk about the offense
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit
As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...
Their friend died of cervical cancer in 2020. Now, they advocate for women’s health in N.S.
Following the death of their close friend from cervical cancer in 2020, two women in Nova Scotia were left wondering how things might have been different had she been diagnosed earlier. Six years later, they have raised over $4 million to improve technology and infrastructure for women's health.
Wrexham’s Summer Striker Decision Faces Fresh Scrutiny After Blackburn Defeat
Wrexham’s decision to back their current centre-forwards has become a renewed talking point after Saturday’s 2–0 defeat at Blackburn Rovers exposed the gap between attacking activity and a meaningful goal threat.
Scientists Found One of The 'Chunkiest' Squid-Like Creatures Ever Known
A "thick and peculiar" cephalopod.
GO Health asks families to be lead-aware
BATAVIA — Area health departments are encouraging families to get the facts and get their children and homes tested for National Lead Poisoning Prevention Week.
Evaluating DJ Herz After Bouncing Back from Injury with Nationals
After making his first MLB appearance in nearly two years, what should the Washington Nationals expect from DJ Herz in his third season with the organization?
What Chelsea Did Wrong vs Tottenham
After a stellar run following the international break, things came crashing down for Chelsea as they lost 2-0 to Tottenham Hotspur at the weekend. This marked an extremely rare defeat at Stamford Bridge to the Lilywhites, a crack in a strong record of home wins that has left fans reeling. In this, we will be …
Aaron Rodgers throws 540th career touchdown, passing Peyton Manning on all-time list
Aaron Rodgers now sits third all-time in passing touchdowns.
Aaron Rodgers passes Peyton Manning on all-time touchdowns list
Aaron Rodgers surpasses Peyton Manning in all-time touchdown passes.
Grading Iowa Football's Loss To Minnesota
This may have been Iowa's worst quarterback performance since the dreadful 2023 season.
Mavericks 'Very, Very Confident' in Rookie PG Behind Kyrie Irving
Spanish sensation Sergio de Larrea shined with 21 points against San Antonio, proving he can anchor the rotation while Dallas carefully manages Kyrie Irving’s heavy workload.
10 Thoughts From Watching Others Sweat It Out
Back during the very lean years of the Ray Goff era in Athens, a certain revered columnist for the Macon Telegraph joked in a weekly prediction column that Georgia would lose to “Open” during its upcoming bye week. Thankfully, those years have passed by, and the outlook for Georgia during open weeks for what is […]
Arch Manning has another viral moment with ESPN's Holly Rowe
The Texas quarterback was happy to see Rowe on the sidelines.
Some Thoughts About Ron Duguay
Dear, departed Ron Duguay was not anything like his playboy image.
Michigan's Jason Beck promised change, but numbers tell another story
Michigan football vowed to fix its perimeter run game or stop it, but the team continues to struggle on the edge.
Halifax Health Sees 19 Biketoberfest-Related Injuries in 2026
With Biketoberfest 2026 having ended on October 18, Daytona Beach’s Halifax Health Medical Center announced the statistics on injuries related to the event. 19 patients were treated for injuries …
17 Celebrity Transformations That Left Fans Doing A Double Take
From Avril Lavigne's “soft makeup era” to JoJo Siwa’s “clean girl” aesthetic, these wild celebrity transformations will leave you gagged.
31 'Brooklyn Nine-Nine' Memes That Would Win a Halloween Heist and Become the Ultimate Detective/Genius
These memes are noice!
Manchester United vs Bournemouth: Live updates from Old Trafford
Under-fire Manchester United manager Michael Carrick is under enormous pressure heading into today’s Premier League clash with Bournemouth on the back of a seven-game run without a win.The boss has ...
Nick Nurse: “Jaylen Brown is obviously very good. He …
Nick Nurse: “Jaylen Brown is obviously very good. He …
"I mean, stuff happens. It's a business. It's not in …
"I mean, stuff happens. It's a business. It's not in …
"I mean, stuff happens. It's a business. It's not in …
"I mean, stuff happens. It's a business. It's not in …
"Jakucionis, he's family. He's an incredible player," …
"Jakucionis, he's family. He's an incredible player," …
Maliek Collins agrees to terms on contract extension
Maliek Collins to remain in Cleveland for two additional years
Former Coach Urges Vikings to Blow Up Kyler Murray Experiment; Trade for… Kirk Cousins?
Jon Gruden has an insane trade idea for the 5-0 Minnesota Vikings and involves a quarterback change that nobody would see coming...
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.