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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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Downtown Chico business owner voices concerns over street closures for events
A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });
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“Loyal Slaves” and Campfire Entertainment in Frank Vizetelly’s Confederate Camp
Frank Vizetelly’s illustration titled “Night Amusements in the Confederate Camp” appeared in the Illustrated London News on January 10, 1863. It was one among a number of wartime scenes that Vizetelly captured for the newspaper. Subscribe Following the war, the illustration appeared in a number of books, including John O. Casler’s Four Years in the Stonewall Brigade (1893) and Campfires of the Confederacy (1898) by Ben La Bree. The scene depicts a Confederate camp at night with an enslaved man, most likely a camp servant, performing a dance around a fire with the music provided by a soldier playing a banjo. Another enslaved man looks on at the right. Vizetelly likely witnessed the scene—one that would have been common throughout the war. It’s a wonderful example of the way in which Confederates—slaveowners and nonslaveowners alike—experienced the presence of slave labor in the army. Vizetelly was deeply sympathetic to the Confederate cause. His depiction of the enslaved man as more than happy to entertain the very people who were fighting to keep him enslaved was precisely the kind of image designed to reassure a British audience that slavery was benign, and by implication, that Britain need not feel morally troubled about recognizing or supporting the Confederacy. Share Just as importantly, the sight of a dancing slave reassured Confederates themselves that the institution of slavery remained secure even after President Lincoln signed the Emancipation Proclamation. I’ve come across this illustration many times before and I plan on using it in my next book project on the role of enslaved labor in the Confederate army during the Gettysburg Campaign, but this is not the reason I am sharing it with you today. It has to do with where I recently found it, which came as a complete surprise and is incredibly revealing. Let’s take a look.
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A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
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A number of heavily indebted Nigerian power producers have ceased operating because their customers aren’t settling their bills and they can’t afford to run their equipment or pay for gas supplies.
‘Just really unique’: Williamsport business preserves history — and finds surprise in basement
“You hate to see history disappear,” said Adam Roskowski, owner of Rosko’s Brew House in Williamsport. That was his motivation for buying the building now housing his craft beer pub at 601 Pine Street. After being vacant for years, Adam was keen to buy the Victorian – not just because of its historic charm but […]
Hail Yeah! NASA Researchers Use Volunteer Observations for Hail Estimates
The bigger the hailstone, the more damage it can cause. But scientists find that predicting hailstone size can be challenging. How quickly does hail melt as it falls?
The war created an oil problem. It’s not the only price you’ll pay
What could get more expensive because of the war in Iran?
Reproductive health clinics scramble as Title X funding cliff approaches
Title X is a 56-year-old federal grant program that supports thousands of clinics that provide birth control and STI testing and treatment around the country. Now those clinics could face a funding gap because of a Trump administration delay.
Legislation shifts too big a burden onto family court
By Judi Atwood I know what a family-court snafu looks like because I lived one. In military slang, a snafu is a breakdown so confused and badly managed the people trapped inside it pay the price. In my own case, the court adopted and preserved findings about my conduct even though I was never served, […]
At 76, I still cycle, train every day, and can do 5 muscle-ups
Ngai Hin Kwok, 76, says he doesn't see a reason to slow down just because he's older.
Trump repeatedly suggests Newsom can’t be president because he has dyslexia
President Donald Trump has repeatedly taken aim at Democratic rival and possible 2028 presidential candidate Gavin Newsom. But lately, he’s become fixated on saying the California governor cannot be president due to his “learning disability.”
Coal Ridge athletic director named best in state after landmark year of Titans prep sports
Ben Kirk did not dedicate his life to the art of sports for recognition or praise. He did it because he knows how much sports can shape a young kid, and how much impact a...
If Trump has already won the Iran war, why does he need foreign ships to help him end it?
A week ago, President Donald Trump told Britain not to bother sending ships to the Middle East because he’d already won the Iran war.
Driving habits of teens and young adults
Nearly all parents think their teen or young adult child’s driving ability is as good or better than other teens and young adults. 1 in 3 parents worry their teen or young adult driver will cause an accident. 1 in 4 parents have taken steps to address their teen or young adult child’s driving behavior. Witnessing risky driving behavior does not affect parents’ rating of their teen or young adult child’s driving ability.
‘I loved it because I love writing’: Student filmmakers, animators strive for a spot in L.A.’s entertainment industry
Hollywood High prepares students for a career in visual media.
Scientists just discovered a tiny signal that volcanoes send before they erupt
A new detection method called “Jerk” could dramatically improve how scientists forecast volcanic eruptions. By using a single broadband seismometer, the system can detect extremely subtle ground movements caused by magma pushing underground—often hours before an eruption begins. Tested for more than a decade at the Piton de la Fournaise volcano on La Réunion, the tool successfully predicted 92% of eruptions between 2014 and 2023, sometimes giving up to eight hours of warning.
Low-cost preventive measures could mitigate spread of bacteria causing neonatal mortality
A new study found that a multifaceted infection prevention and control intervention could at least temporarily thwart outbreaks of infections from the Klebsiella pneumoniae bacterium, a leading cause ...
Finalissima between Spain, Argentina canceled in Qatar because of regional conflict during Iran war
European champion Spain were originally scheduled to take on Copa America winners Argentina on March 27 in Qatar
Emotional Abuse in College Sports
March Madness is here. The high-stakes, sudden-death college basketball tournament is a beloved tradition in American sports. For the players, it’s a chance to showcase the skills they’ve developed through years of hard training of the body and mind. In many cases, that push produces incredible feats of athletic performance. But an investigation by reporters Julia Haney and Elizabeth Santos has found instances in which athletes allege that the push from coaches goes too far. Emotional abuse by coaches, some athletes maintain, can cause lasting, even irreparable damage. On this episode of The Sunday Story, we hear from athletes who fought back.*A warning that today’s story includes mentions of sexual and emotional abuse, suicide, bullying and includes explicit language.
Study warns chatbot may cause hallucinations
A new study claims AI-powered chatbots may encourage delusional thinking, especially among vulnerable people.
These Wausau businesses & churches closed March 15-16 due to snowstorm
Here's a list of businesses and churches in the Wausau area that have announced closures for March 15 and 16 because of the forecasted snowstorm
These Wausau businesses & churches closed March 15-16 due to snowstorm
Here's a list of businesses and churches in the Wausau area that have announced closures for March 15 and 16 because of the forecasted snowstorm
These Marshfield businesses & churches closed March 15-16 due to snow
Here's a list of businesses and churches in the Marshfield area that have announced closures for March 15 and 16 because of the forecasted snowstorm.
These Marshfield businesses & churches closed March 15-16 due to snow
Here's a list of businesses and churches in the Marshfield area that have announced closures for March 15 and 16 because of the forecasted snowstorm.
These WI Rapids businesses & churches closed March 15 due to snowstorm
Here's a list of businesses and churches in the Wisconsin Rapids area that have announced closures for March 15 because of the forecasted snowstorm.
Leonard's 28 leads Clippers past Bulls for fourth straight win
With Darius Garland sidelined because of a left toe injury, Leonard delivered 28 points to lead the Clippers past the Chicago Bulls 119–108 Friday night at Intuit Dome.
New Business: Robotics and AI rule at Hudson coffee drive-thru; new T-Bones open in Hudson
The best thing about the new coffee drive-thru in Hudson might be the fact there’s no need to scan QR codes or tip. That’s because behind the scenes robots are
America has health alarm fatigue. I know because I treat it
“We cannot let alarm fatigue silence the response to Kennedy’s and Trump’s destruction,” writes Robert Shpiner.
Business of golf betting is booming – and a Tiger Woods Masters showing could cause an explosion
The business of golf is booming, and there is a white whale that could force an explosion.
Power outage stalls business at Mass. State House
A State House electrical outage ended around noon Thursday after the Legislature’s website and internet connectivity within the building were knocked out of commission Wednesday evening. Legislative Information Services sent an email to legislative members and staff on Wednesday around 9 p.m., stating that an electrical outage in the State House caused a service disruption. Portions of the building were running…
These women want to have babies. They say Trump's policies are getting in the way.
Some women who want to grow their families are choosing not to because of affordability, lack of access to maternal health care and other fears.
Calls for investigations of recent Rensselaer Co. elections
Common Cause New York, For the People, and the League of Women Voters of Rensselaer County sent a letter to state Attorney General Letitia James.
What Is the Most Addictive Drug? Science May Have Some Answers
When considering the drugs most likely to cause former addicts to repeatedly relapse, opioids, cocaine, and methamphetamine stand out as the most dangerous.
One-third of Americans skip meals or other needs to afford health care
About half of middle-income households said they have delayed a major life event because of medical costs, new Gallup polls found.
Lilly finds impurity in compounded version of its weight-loss drug, warns of health risks
Compounded weight-loss drugs that contain vitamin B12 and the main ingredient in Eli Lilly's Zepbound could present health risks to consumers due to a previously unidentified impurity caused in the preparation, the U.S. drugmaker said in a public letter released on Thursday.
1-Up Games strengthening business 1 month after reopening
In May of last year, a devastating fire caused 1-Up Games in Yakima to scramble to find a way to stay open. In February, they reopened."There was a lot of uncer
One-Third of Americans Cut Back to Cover Healthcare Expenses
According to new West Health-Gallup research, millions of Americans report cutting back on expenses and delaying plans because of healthcare costs.
Beyond The Burn Zone: Maui Wildfires Cause Widespread Mental Health Issues
New research shows housing displacement and income loss were central drivers of psychological harm.
Iran’s sports minister says country can't take part in World Cup because of U.S. attacks
Iran was expected to take part in the World Cup that will be held across North America in June, but Iranian Sports and Youth Minister Ahmad Donyamali told state television that his country’s soccer team players are not safe in the U.S., according to a video of the interview posted Tuesday.
Initial thoughts on Colts’ first free-agent moves
First wave of free-agency done, and the Colts have moved as many of us expected, which is rather surprising. It usually does not transpire like this, I was especially surprised by the Pittman and Franklin moves because I did not expect them to happen, but here are my hot opinions on what Ballard and Steichen […]
Astronomers think they just witnessed two planets colliding
Astronomers have caught what may be a rare cosmic catastrophe unfolding 11,000 light-years away. A seemingly ordinary sun-like star suddenly began flickering wildly, puzzling scientists until they realized the strange dimming was caused by vast clouds of hot dust and debris drifting across the star. The most likely explanation is a violent planetary collision—two worlds smashing together and scattering glowing material throughout the system.
CERN Science Gateway celebrates its 1000th science show
CERN Science Gateway has reached another milestone: the delivery of its 1000th science show! Since opening its doors in October 2023, Science Gateway has welcomed nearly 900 000 visitors of all ages to explore the fundamental questions of the Universe. Among its most popular activities are the science shows – dynamic, interactive demonstrations led by CERN guides and tailored to a broad audience of different age levels, including school groups, families and the general public. Designed to make complex scientific concepts accessible and entertaining, these live shows combine spectacular experiments, multimedia elements and audience participation. From the physics of particle collisions to the properties of superconductivity, electromagnetism and cryogenics, the science shows translate the research carried out at CERN into engaging visual experiences. Visitors might see superconductors levitate, follow particles through different detector layers or discover the beauty in phase transitions. Each demonstration is carefully crafted to spark curiosity while maintaining scientific accuracy. Members of the CERN community are of course warmly invited to visit CERN Science Gateway with their family or friends and attend one of the science shows. To register, please visit this page, and don’t forget to check the programme for the coming days. Become a CERN guide and run your own super-cool science show (and more)! To become a CERN guide, you can join the introduction course held every 3–4 weeks, which will give you an overview of what being a CERN guide entails. From there, further courses are available depending on what type of guide you would like to be. Because, of course, CERN guides are needed everywhere at CERN. If you imagine yourself as a more ‘traditional’ guide, you should know that there are currently more than ten exciting visit points in CERN’s visits portfolio, such as the Antimatter Factory, the ALICE experiment (surface), the Alpha Magnetic Spectrometer (AMS) control room, the ATLAS experiment (surface), the CERN Control Centre (CCC), the Data Centre, the LHCb experiment (surface), the Synchrocyclotron (SC), the SM18 test facility and the newly inaugurated Linac2 visit point. Indeed, CERN’s Visits Service and Visual Impact and Exhibitions Section recently collaborated on redesigning the Linac2 visit tour, which has just reopened to the public after several months of renovation work. The new tour offers visitors and guides alike an enriched, more immersive experience, designed to highlight the history and scientific significance of this major facility. So, fancy becoming one of the insiders? Join the introduction course, check the guides website or contact guides.manager@cern.ch. And remember, becoming a guide can benefit you, too.
Trump Hotel restaurant flunked December health inspection because it was ‘affected by pests’
A city health inspector cited the restaurant at Trump's Chicago tower for a handful of violations in December.
Sports gambling could be boosting binge drinking in young men
Men aged 35 or younger who already drink heavily may be even more likely to binge alcohol because of legal online sports betting, a new study has found
The dangerous politics of US oil-driven redistribution
U.S. stock market indexes have weathered this month's oil shock well so far because investors expect only a glancing overall GDP hit from higher energy costs. But that resilience masks a potentially toxic shift of income from households to "Big Energy" - and packs big risks in an election year.
Georgia Independent Wrestling’s Empire of Entertainment
“I remember just standing there that night, and I could feel this connection between the fans and the performers in a way that I hadn’t really ever felt before, which makes sense now that I know more about wrestling, because fans really have agency over the action in the ring. The louder they cheer, the more the wrestler is going to labor to his feet. Wrestling doesn’t really work without an audience,” says Athens journalist Alison Lyn Miller, who published the nonfiction book Rough House: A Father, a Son, and the Pursuit of Pro Wrestling Glory earlier this year. Miller wasn’t a wrestling fan when she attended the now-defunct Southern Violence And Wrestling match back in 2019, but her passion […]
Bondi reportedly moved to military housing because of threats
Other officials who have relocated include Secretary of State Marco Rubio; Kristi Noem, the exiting homeland security secretary; and Defense Secretary Pete Hegseth.
HCMC doctor says hospital's closure would endanger health database, cause "public health crisis"
The fight to keep Minneapolis' Hennepin County Medical Center open is in full swing, with leaders saying the hospital is in grave danger of closing after Medicaid cuts and budget confusion.
Doctor says Minneapolis hospital closure would cause "public health crisis"
Bondi Is Said to Move to Military Housing Because of Threats
The attorney general relocated from a Washington apartment to a base in the area within the past month, according to people familiar with the situation.
Scientists discover tiny plant trick that could supercharge crop yields
Researchers have uncovered a molecular trick used by hornwort plants that could help future crops capture carbon dioxide more efficiently. A unique protein feature called RbcS-STAR causes the key photosynthesis enzyme Rubisco to cluster into dense compartments, helping it work more effectively. When scientists added this feature to other plants, Rubisco reorganized in the same way. The finding raises the possibility of engineering more efficient photosynthesis into major crops.
Ocean warming may supercharge a tiny microbe that controls marine nutrients
As deep-sea waters warm, scientists expected trouble for the microbes that help keep ocean chemistry in balance. Instead, researchers found that Nitrosopumilus maritimus can adapt to warmer, iron-limited conditions by using iron more efficiently. Because these microbes control key nitrogen reactions that support marine life, their adaptability could help sustain ocean productivity. In a warming world, they may play an even bigger role in shaping marine nutrient cycles.
Senate Moves Toward Passing Sweeping Housing Bill, but Challenges Lie Ahead
The legislation’s progress is all the more surprising because it addresses an issue that is shaping up to be the main battleground of the midterm elections: affordability. The effort could still stall.
WHO warns of health risks from 'black rain' in Iran
The World Health Organization warned on Tuesday that the "black rain" falling in Iran after strikes on oil facilities could cause respiratory problems, and it backed Iran’s advisory urging people to remain indoors.
Scientists discover molecule that stops aggressive breast cancer in its tracks
Scientists at Oregon Health & Science University have developed a new molecule that could open the door to treating triple-negative breast cancer, one of the most aggressive and difficult-to-treat forms of the disease. The compound, called SU212, targets and disables a key enzyme that cancer cells rely on to fuel their growth. In tests using humanized mouse models, the molecule caused tumors to shrink and slowed the spread of cancer by forcing the enzyme to break down.
Mental health solutions for the digital age
Ask the digital natives of Gen Z about the source of their biggest mental health challenges, and most will say social media and AI.Several of the nearly 400 guests at the third annual Gen Z Wellness Summit, presented by the Friends of Semel Teen Advisory Council at UCLA on March 8, explicitly named the endless stream of content on their phones as serious stressors. “Everybody is addicted to (Tik Tok) as if they were addicted to substances,” said Jantin Asmar, 17, a senior at Virtual Academy in Antelope Valley. “We’re always chasing that dopamine. We’re expecting that dopamine rush and it’s really decaying our interactions with others.” High school student Jantin Asmar was among nearly 400 people who attended the third annual Gen Z Wellness Summit. (Photo by Sandy Cohen) Even young teens feel pressure to be on social media constantly, both to consume content and collect “likes,” said 13-year-olds Chloe and Sophia, both students at Brentwood School. “Everyone’s always on, and you miss stuff if you’re not on it,” Chloe said, adding that social media’s emphasis on appearances is leading to eating disorders: “That’s a big thing for our generation.”The incessant influx of images and updates creates expectations that “weigh teenagers down,” said Linda Kou, 16, a junior at San Gabriel High School.Even though digital spaces allow people to connect with others beyond their immediate surroundings, it doesn’t always translate to real-life community, said Kelah Morgan, 17, a senior at Animo South Los Angeles Charter High School. High school students Kelah Morgan, left, and Linda Kou, shared about the challenges presented by social media. (Photo by Sandy Cohen) “Even if you see people saying that they relate to you online, it might be hard to find people in your personal life who you see every day who you feel comfortable enough to say, ‘You see me online, but this is me in real life and what I’m actually going through,’” she said.Solutions for our digital timesThe Gen Z Wellness Summit was intentionally designed as a free, in-person gathering where young people interested in mental health from across the southland could meet in person. “Peer support is the most important element of maintaining our mental health in community,” said Helena Hansen, MD, PhD, director of UCLA’s Semel Institute for Neuroscience and Human Behavior.Keynote speakers at the summit addressed AI, social connection and self-empowerment, while breakout sessions included discussions about eating disorders, dating, substance use, phone detox and breathwork. Here are some of the day’s top takeaways:Beware of FOPO: Scott Barry Kaufman, PhD, a psychology professor at Columbia University, said that rather than FOMO, or fear of missing out, we ought to be more aware of FOPO: fear of people’s opinions. “Just think about how much your FOPO might be holding you back in your life,” Dr. Kaufman said. “And just that inner contemplation should be enough for you to change your life, because there’s so many things we don’t go after because we have debilitating FOPO.”We don’t need to feel like we’re the best – or what he called “narcissistic self-esteem” – but it’s helpful to acknowledge our own worth, recognize our good qualities and develop self-belief in the skills and talents we’ve cultivated. When we have that – dignity and self-respect, without needing everyone to like us – FOPO is less of a concern.Self-reflection is most effective in community: “When we try to self-reflect alone, we sometimes ruminate,” said Ira Bedzow, PhD, executive director of the Emory University Purpose Project. “But when we self-reflect with people that we trust … (it) allows us to hold ourselves accountable to different ways of seeing and different ways of hearing and different ways of being.”Opening up about our experiences and listening to others are skills we can develop, Dr. Bedzow said.He invited students to participate in what he called a “fishbowl exercise,” where four students sat in a small circle, surrounded by a dozen or so students forming a larger circle. Those in the inner circle answered such questions as: “What stops you from being you today?” and “What helps you feel most like you?”Within minutes, the group in the small circle (the fishbowl), were sharing intimately about their life challenges as those in the outer circle nodded in understanding.After the exercise, one participant said, “I felt like I wasn’t alone, that it wasn’t just me who feels that way.”Another remarked on how “personal” it felt to share face-to-face with others, even strangers.Don’t let AI crush your creativity: Theoretical neuroscientist Vivienne Ming, PhD, has been studying artificial intelligence for more than 20 years. And while she said “it’s reasonable to be concerned” about the fast-growing technology, it can also help humans become better problem-solvers when used strategically.“The smartest thing on the planet today are humans and machines working together creatively,” Dr. Ming said. “What gets more valuable in humans as machines get smarter? Our ability to explore the unknown.“Your unique voice is literally your value to the world … but most of us for most of our lives have been taught to not be unique,” she continued. “Be your own person. Celebrate being different. It is genuinely, measurably, truly valuable.”In a breakout session called “Phone Detox? IYKYK: Living Your Story IRL” led by Don Grant, PhD, students shared their frustrations with AI compromising academic work, art and creativity.“Art is a translation of human experience,” one participant said. “When people use AI, they diminish their own human experience.”Dr. Grant urged them, as “the last generation to remember a world before AI,” to remember the power of imagination and creativity – and to act on it.Remember that social media distorts perceptions: Stuart B. Murray, PhD, PsyD, who directs the Eating Disorders Program and Translational Research in Eating Disorders Program at UCLA, asked the students in his breakout session to take a spontaneous selfie and edit it to conform with society’s beauty standards. All 20 girls in the room immediately got to work, thickening their hair, slimming their faces, plumping their lips.“The pressure to look like what we present on social media can be crippling,” Dr. Murray said. “We now know that social media use is part of a causal pathway into an eating disorder.”Adolescents and young adults are most at risk of developing an eating disorder, he said, with one in three students on college campuses exhibiting clinically meaningful eating-disorder symptoms. More than 4 million people in California will have an eating disorder in their lifetime.Even for those who don’t develop anorexia or bulimia, the ubiquity of modified images online distorts what we consider normal, making us feel worse about ourselves. Remembering that, he and other speakers said, might inspire us to log off occasionally and spend time in the real world with people who love us as we are.
A warrant should mean something — expedite carrying them out
By Aaron Ping My name is Aaron Ping. I am a father from Washington state, and I am writing because my 16-year-old son, Avery, cannot. Avery died on Dec. 19, 2024. The drugs that killed him were ordered through Snapchat. I knew my son. This was not a pattern. This was an impulsive experiment — […]
Anthropic executives say Pentagon blacklisting could hit billions in sales, harm reputation
Anthropic executives said the U.S. government's blacklisting of the AI firm could cut its 2026 revenue by multiple billions of dollars and cause reputational harm.
WATCH: Trump sidesteps responsibility for deadly strike on Iranian girls' school
President Donald Trump erroneously claimed Monday that Iran has access to the American Tomahawk cruise missile, the weapon likely used to strike a girls' school in Iran, killing 165 people. When asked why he was the only person in his administration making the claim, Trump replied: “Because I just don’t know enough about it.”
LSA needs to scrap its natural science requirement
To meet LSA’s natural science requirement, most students select two of these courses and exert the minimum effort needed to acquire an A — which could be a problem because most feel they’re learning next to nothing. LSA’s natural science course requirement forces students to take classes they lack interest in and fails to achieve any meaningful development of natural science skills or knowledge. It should be scrapped.
NBA cancels Atlanta Hawks’ plans to celebrate famed Magic City adult entertainment club
The NBA has called off the Atlanta Hawks' plans for a night celebrating the city's famed Magic City adult entertainment club, saying it did so because of “concerns” from many across the league.
The Scientists Who Declared War on Half of America
With Science Under Siege: How to Fight the Five Most Powerful Forces that Threaten Our World, climatologist Michael E. Mann and virologist Peter J. Hotez have written an important book. When future historians look back at the early twenty-first century and document the causes and consequences of the intense politicization of the U.S. scientific community, […]
This Cheetah Hits the Brakes Inches from a Human (And the Science Explains Why)
Conservation in Namibia, Africa, has an orphaned cheetah who lives with them because his mother was shot when he was just a...
The Surprising Science Of Why Sneakers Squeak
The forces that cause sneakers to squeak also create mini-earthquakes (shoe-quakes, if you will) and tiny lightning bolts.
At Indian Wells, tennis crowds, tickets and show courts form a complex equation
A new ticketing policy has caused controversy, as tournaments across the world try to find the balance between economics and fan experience.
Neel: Politics has become a product
Once, politics was about ideas, debate and action. Today, it increasingly feels like a marketplace. Candidates, causes and even movements are packaged, marketed and sold like consumer goods. Everything from slogans to social media posts is designed less to solve problems than to capture attention, gain followers and generate revenue. The thingification of politics, the...
Sports photographer captures epic photo of Moorhead/Edina scuffle
Friday night’s Class AA state semifinal between Edina and Moorhead ended in a 3-1 victory for the Spuds. A hit at the final buzzer caused a bit of a scuffle between the two teams, and Andrew Ritter captured an epic photo of it.
Corpus Christi executive leaders spearhead local women’s heart health movement
CORPUS CHRISTI, Texas, March 3, 2026 — Cardiovascular disease (CVD) is the leading cause of death for women[1] in Corpus Christi and across the United States. To change that, the American Heart Association, a relentless force changing the future of...