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Carrie Anne Fleming, 'Supernatural' and 'iZombie' actress, dies at 51
Carrie Anne Fleming, who appeared on 3 episodes of 'Supernatural' as Bobby's wife Karen, has died. She was 51.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Sony PlayStation Network down: PS5 users report widespread server issues; 'please fix it'
Sony PlayStation Network appeared to be down for thousands on Saturday as many flocked to social media to voice their complaints. | World News
Scammer is trying to defraud Norwalk Oyster Festival vendors, Better Business Bureau says
The Better Business Bureau (BBB) is warning people about a scam involving the Norwalk Oyster Festival. Jerry Toni, the executive director of the Norwalk Seaport Association, which runs the festival, told the BBB that a scammer is posing as his business and trying to defraud vendors. The scammer contacted previous Norwalk Oyster Festival vendors and appeared credible, the BBB said….
Letai: “From this point forward, it really is much more like business as usual at the NCI.”
NCI Director Anthony Letai appeared before the National Cancer Advisory Board Committee March 17 to maneuver through thorny topics while reiterating his message of reassurance: Stability. Stability. Stability. NCI is sturdy and will weather the storms. “The mission hasn’t changed at the National Cancer Institute,” Letai said in his remarks to the committee. “The resources […]
“Loyal Slaves” and Campfire Entertainment in Frank Vizetelly’s Confederate Camp
Frank Vizetelly’s illustration titled “Night Amusements in the Confederate Camp” appeared in the Illustrated London News on January 10, 1863. It was one among a number of wartime scenes that Vizetelly captured for the newspaper. Subscribe Following the war, the illustration appeared in a number of books, including John O. Casler’s Four Years in the Stonewall Brigade (1893) and Campfires of the Confederacy (1898) by Ben La Bree. The scene depicts a Confederate camp at night with an enslaved man, most likely a camp servant, performing a dance around a fire with the music provided by a soldier playing a banjo. Another enslaved man looks on at the right. Vizetelly likely witnessed the scene—one that would have been common throughout the war. It’s a wonderful example of the way in which Confederates—slaveowners and nonslaveowners alike—experienced the presence of slave labor in the army. Vizetelly was deeply sympathetic to the Confederate cause. His depiction of the enslaved man as more than happy to entertain the very people who were fighting to keep him enslaved was precisely the kind of image designed to reassure a British audience that slavery was benign, and by implication, that Britain need not feel morally troubled about recognizing or supporting the Confederacy. Share Just as importantly, the sight of a dancing slave reassured Confederates themselves that the institution of slavery remained secure even after President Lincoln signed the Emancipation Proclamation. I’ve come across this illustration many times before and I plan on using it in my next book project on the role of enslaved labor in the Confederate army during the Gettysburg Campaign, but this is not the reason I am sharing it with you today. It has to do with where I recently found it, which came as a complete surprise and is incredibly revealing. Let’s take a look.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Luka Doncic and Austin Reaves Are Fulfilling Lakers’ Expectations
Here comes the Los Angeles Lakers. Don’t look now, but the Lakers are playing some incredible basketball. Not only that, but they also look GOOD doing it. Just a few weeks ago, fans were down on what the ceiling was for this team. Another first-round exit? Maybe a possible Play-In appearance even? But now, the […] The post Luka Doncic and Austin Reaves Are Fulfilling Lakers’ Expectations appeared first on The Lead.
Maxx Crosby Trade Attempt Shows Ravens’ New Aggresive Strategy
The Baltimore Ravens rarely chase blockbuster trades, but their pursuit of Maxx Crosby suggested a different level of urgency. The trade suggested an “all in” motto from a franchise that is known for patience and draft-driven roster building. The deal ultimately fell apart before it could be finalized. Even so, the attempt revealed a willingness […] The post Maxx Crosby Trade Attempt Shows Ravens’ New Aggresive Strategy appeared first on The Lead.
Trump Jokes About Pearl Harbor in Meeting With Japan’s Leader
Breaking a taboo, President Trump needled Japan’s prime minister about the World War II attack, as she widened her eyes and appeared to take a deep breath in the Oval Office.
AMD "Medusa Point" APU Early Benchmarks Match "Strix Point" at Half the Clock Speed
AMD is preparing to launch its "Medusa Point" APU in early 2027. However, more benchmarks are emerging to showcase what the actual SoC can do as AMD and its OEM partners test the chip. In the latest Geekbench v6 run, AMD's 10-core, 20-thread "Zen 6" chip appeared with the AMD Engineering Sample numb...
iOS 26.4 Fixes iPhone Keyboard Accuracy Bug
The iOS 26.4 update that Apple plans to release as soon as next week includes improvements for the built-in iOS keyboard. In its notes for the software, Apple says iOS 26.4 offers "improved keyboard accuracy when typing quickly". There was a bug in iOS that caused some characters to be missed when a user was typing quickly. The character appeared to be tapped in the keyboard, but was ultimately not inserted.
AMD Medusa Point leak shows 10-core Zen 6 APU beating Ryzen AI 9 365 in Geekbench multi-core
AMD Medusa Point Zen 6 APU appears again with higher Geekbench score AMD’s Medusa Point APU has appeared in Geekbench again, this time with a much higher
Paleontology has an Epstein problem. Women in the field say it's a symptom of a deeper misogyny
The names of hundreds of scientists have appeared in the Epstein files, including prominent dinosaur researchers. As the paleontology community reckons with the fallout of these revelations, women in the field say it's bringing to the forefront what they've known for years — that paleontology is ripe with abuse and harassment, and its institutions protect men at the top at the expense of women trying to build careers in spaces that treat them as disposable.
Your daily coffee may be protecting your brain, 43-year study finds
Your morning coffee or tea could be quietly supporting your brain health. A long-term study found that moderate consumption of caffeinated coffee or tea was linked to an 18% lower risk of dementia and better cognitive performance over time. The benefits appeared strongest at 2–3 cups of coffee or 1–2 cups of tea daily—and even held true for people genetically predisposed to dementia.
Webb telescope photos show mysterious little red dots. Astronomers don’t know what they are
Hundreds of mysterious objects have appeared in images captured by the Webb space telescope. The curious dots could reshape scientists’ understanding of the cosmos.
Breaking: First One UI 9 build is here for the Galaxy S26 Ultra
Samsung has started the development of the Android 17-based One UI 9 update for the Galaxy S26 Ultra. It has appeared on Samsung's servers.
Oscars unite 17 Rob Reiner stars for emotional tribute: Here's who appeared on stage
Oscars untied a supergroup of Rob Reiner actors for an emotional tribute on stage. Here's who appeared at the Academy Awards, from Demi Moore and Kathy Bates to Meg Ryan and Billy Crystal.
Scientists discover hidden water beneath Mars that could have supported life
New research suggests Mars may have remained habitable much longer than scientists once thought. Ancient sand dunes in Gale Crater appear to have been soaked by underground water billions of years ago, leaving behind minerals that can preserve signs of life. Even after surface water disappeared, subsurface flows may have created protected environments for microbes. These hidden habitats could be key targets in the ongoing search for past life on Mars.
Overlooked? ESPN Names Under-the-Radar Steelers Addition
The Pittsburgh Steelers have made a concerted effort to improve their secondary in free agency. They’ve shored up the back […] This article originally appeared on Steelers Now: Overlooked? ESPN Names Under-the-Radar Steelers Addition
Have the Giants Been Aggressive Enough in Free Agency?
Though they haven’t made any groundbreaking additions, the New York Giants have been quite active in free agency. The Giants have brought back players like Jermaine Eluemunor and Micah McFadden, while adding newcomers such as Isaiah Likely, Tremaine Edmunds, and Patrick Ricard. But after restructuring and cuts before free agency, there were hopes of retaining more […] The post Have the Giants Been Aggressive Enough in Free Agency? appeared first on The Lead.
Who Will Be the Packers’ Next Quarterback Redemption Story?
The Green Bay Packers have become victims of their own success. Matt LaFleur has had to rely on backup quarterback Malik Willis several times over the past two seasons. Willis stepped up impressively, leading the Packers’ offense to nine touchdowns with only one turnover in 11 games. Willis clearly benefited from working with LaFleur and the […] The post Who Will Be the Packers’ Next Quarterback Redemption Story? appeared first on The Lead.
Japan PM’s health sparks concern before Trump summit
Japan’s Prime Minister Sanae Takaichi appeared unwell at a budget committee session on Thursday, which sparked concerns over her health. This comes less than a week before her meeting with President Trump in Washington. On Friday, Japan’s government said she has recovered and returned to official duties. CNN’s Hanako Montgomery reports.
Scientists find a new therapeutic target present on up to half of all tumors
For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth ...
Medicare Advantage 'dark money' group tries to win higher payments for insurers
What appeared to be a surge of grassroots support for higher Medicare Advantage payments was actually driven by a pro-industry group.
'People feel betrayed.' Joe Rogan slams Trump's 'insane' Iran war.
Trump appeared on Rogan’s popular podcast in 2024, and Rogan endorsed him on the day before the election.
GeForce RTX 5050 9GB G7 variant reportedly has the same 130W TDP as 8GB G6 model
Featured, GeForce RTX 5050, Leak NVIDIA RTX 5050 9GB spotted in shipping manifest NVIDIA's rumored GeForce RTX 5050 9GB variant has now appeared again, this time with more detailed
Sebastian Tounekti’s dig at Rangers following Celtic’s Ibrox win
Celtic winger Sebastian Tounekti appeared to mock the Rangers following the Hoops’ dramatic Scottish Cup triumph at Ibrox…Liam Scales celebrates after Celtic won the Scottish Cup quarter final on ...
Here’s how the new M5 Max chip did on early Geekbench tests
While the new Macs won’t be available until March 11, the first M5 Max benchmark has already appeared on Geekbench. Here are the results.
You Break It, You Own It? Not for Trump When It Comes to Iran
“We’ll see what happens with the people,” President Trump said as he appeared to be distancing himself from the longer-term consequences of the war in Iran.
Trump Administration, in Apparent Reversal, Tries to Continue Fight Against Law Firms
The administration told a court on Monday that it was abandoning its defense of executive orders targeting the firms. But on Tuesday, the Justice Department appeared to abruptly change its position.
Apple Accidentally Leaks 'MacBook Neo'
Apple appears to have prematurely revealed the name of its rumored lower-cost MacBook model, which is expected to be announced this Wednesday. A regulatory document for a "MacBook Neo" has appeared on Apple's website. Unfortunately, there are no further details or images available yet. Unfortunately, there are no further details or images available yet.
House panel releases videos of Clinton depositions in Epstein investigation
Former president Bill Clinton and former secretary of state Hillary Clinton appeared last week before the Republican-led House Oversight Committee.
Supreme Court signals it will back marijuana user who was charged with owning a gun
The Supreme Court appeared likely Monday to curb the government’s ability to disarm a frequent marijuana user, though several of the justices were also wary of completely undermining a 1968 law that was intended to ensure that Americans addicted to drugs don’t have access to firearms.
Ancient Microbes Fused Into Earth’s First Complex Cells. Scientists Just Learned What Made It Possible.
Around 1.7 billion years ago, eukaryotes—the building blocks of complex life—first appeared on Earth, and now scientists have solved a longstanding riddle about their origin.
Trump officials decline Sunday show invitations amid Iran strikes
No senior Trump administration officials or cabinet members appeared on the Sunday show television circuit a day after the US and Israel began a major military operation in Iran, killing Iran’s Supreme Leader Ayatollah Ali Khamenei.
Speedy WR Named Perfect Free-Agent Signing For Steelers
The Pittsburgh Steelers could look to add a ton of speed to their offense this offseason. This article originally appeared on Steelers Now: Speedy WR Named Perfect Free-Agent Signing For Steelers
2026 QB Prospect Receives Comp to Steelers WR DK Metcalf
One of the quarterbacks in the 2026 NFL Draft has been compared to Pittsburgh Steelers wide receiver DK Metcalf. This article originally appeared on Steelers Now: 2026 QB Prospect Receives Comp to Steelers WR DK Metcalf
Trump Decision to Strike Iran Opens Fissures in Midterms
Republicans largely supported the decision, while Democrats mostly opposed it — but divisions appeared in both parties.
Did Sydney Sweeney hit Bruno Fernandes' goal celebration?
Hollywood star Sydney Sweeney visited Sporting and appeared to imitate the trademark celebration of one of the club's former players, Bruno Fernandes.
Pennsylvania politicians react to U.S., Israel strikes in Iran
Pennsylvania lawmakers are weighing in after the U.S. and Israel launched a major attack on Iran. After the first strikes Saturday appeared to hit areas...
Hillary Clinton derides her Epstein deposition as GOP ‘political theater’
Hillary Clinton appeared before the House Oversight Committee as she began hours of closed-door testimony in front of the Republican-led panel.
Steelers Not Expected to Release Highly-Expensive Veteran
The Pittsburgh Steelers are preparing to hold onto one of their most expensive players. This article originally appeared on Steelers Now: Steelers Not Expected to Release Highly-Expensive Veteran
WWE Superstar Says Tom Brady Is on His ‘RKO’ List
Randy Orton has added a surprising name to his “RKO list.” After Tom Brady referred to WWE as “cute” during a recent podcast appearance, the 14-time world champion responded with a playful warning. Orton now says that the seven-time Super Bowl winner is someone he would love to hit with his signature move. Tom Brady […] The post WWE Superstar Says Tom Brady Is on His ‘RKO’ List appeared first on Mandatory.
Kazakhstan plants tens of thousands of trees in giant effort to reintroduce tigers
Kazakhstan planted 37,000 seedlings and cuttings in South Balkhash last year to prepare for the return of its tigers, which disappeared more than 70 years ago.
Robert Adamson, RWJBarnabas Health Chief Information Officer, Honored by Becker’s Hospital Review as a 2026 CIO to Know
Robert T. Adamson, PharmD, FASHP, Executive Vice President and Chief Information Officer of RWJBarnabas Health, was honored as one of just 135 hospital and health system CIOs to know nationwide by Becker’s Hospital Review. This is the second consecutive year that Dr. Adamson has appeared on this list.
'A place of extremes': Scientists unveil the largest-ever map of the galaxy's chaotic center
Scientists using the ALMA telescope have created the most-detailed-ever map of the Milky Way's chaotic center. The observations could open a window to the ancient universe as it appeared shortly after the Big Bang.
Floyd Mayweather & Manny Pacquiao Returning for a Second Fight
Floyd Mayweather and Manny Pacquiao are set to fight it out in a rematch this year. According to reports, the two will battle it out on September 19 at the Spere in Las Vegas. Viewers can watch the fight live on Netflix. Although both boxers are past their prime, fans are stoked to watch them […] The post Floyd Mayweather & Manny Pacquiao Returning for a Second Fight appeared first on Reality Tea.
OnePlus 16 leak reveals sub-1 mm display bezels
The next-generation OnePlus flagship, expected to be called the OnePlus 16, has appeared in a fresh leak. It suggests the device could feature even thinner bezels than the OnePlus 15.
PS Plus Essential March Games Leak May Disappoint PS5 Owners
A new leak regarding the upcoming PS Plus Essential March 2026 games has appeared online, and may leave some fans a bit disappointed.
From bakeries to beauty shops, Russian businesses are feeling the pain from a new wartime tax policy
Denis Maksimov’s bakery in suburban Moscow became famous overnight after he appeared on President Vladimir Putin’s annual call-in show in December.
From bakeries to beauty shops, Russian businesses are feeling the pain from a new wartime tax policy
Denis Maksimov’s bakery in suburban Moscow became famous overnight after he appeared on President Vladimir Putin’s annual call-in show in December. Standing in front of the bakery — called Mashenka, after his oldest daughter -– he pleaded with Putin via video to look into new tax reforms that are significantly increasing the burden on small businesses like his. As Putin's full-scale invasion of Ukraine marks four years, the mounting pressure on Russia’s economy is starting to show.
Man shot and killed after entering Mar-a-Lago perimeter, Secret Service says
The Secret Service said the man was observed carrying “what appeared to be a shotgun and a fuel can.”
Pokemon FireRed and LeafGreen listings appear on Nintendo eShop
A listing for Pokemon FireRed and LeafGreen have appeared on the “Coming Soon” tab of the eShop. Both titles are priced at $19.99, and are set to release on February 27, 2026. The title is stated to support local wireless play, with Pokemon Home support being added at a later time. It should be noted that each language has its...
Chicago Bears Move One Step Closer to Northwest Indiana
The Chicago Bears’ long-running stadium search moved closer to becoming reality in Northwest Indiana on Thursday, as state officials signaled Hammond as the preferred site and lawmakers advanced legislation designed to support construction of a new NFL stadium. The shift comes as excitement around the franchise has surged following a strong season that included a […] The post Chicago Bears Move One Step Closer to Northwest Indiana appeared first on Capital B Gary.
Breaking Down 12 External Quarterback Options for the Steelers
For the third straight offseason, the Pittsburgh Steelers are staring at a fairly bleak situation when it comes to the […] This article originally appeared on Steelers Now: Breaking Down 12 External Quarterback Options for the Steelers
How Can Broncos Add the “Pop” ESPN Is Looking For?
“Offseason in three words: Find some pop.” That’s what ESPN stated in a column regarding the Broncos’ needs for their 2026-27 season via their power rankings back on Feb. 8. And they’re correct — with a few key pieces of Denver’s roster set to be a free agent this summer, the Broncos are going to […] The post How Can Broncos Add the “Pop” ESPN Is Looking For? appeared first on The Lead.
Every pair of headphones tested contained hazardous chemicals
A study of 81 headphones found hazardous chemicals in every pair. BPA appeared in 98% of samples, and sweat speeds absorption.
Ray J performs with bleeding eyes weeks after revealing he has months to live
Singer Ray J performed a concert on Saturday with what appeared to be bleeding eyes and something taped to his chest, weeks after claiming he only has months to live: 'I'm putting my life on the line for this show!'
Aliens are ‘real,’ Obama says, as Washington shrugs
The former president appeared to confirm decades-old conspiracy theories. Lawmakers say Barack Obama is simply saying what many Americans already believe.
Jeff Stoutland’s Eagles Departure Signals Major Organizational Changes
News broke on Feb. 4 that Jeff Stoutland, the Philadelphia Eagles’ run game and offensive line coach, will not return to the team next season. The report from ESPN’s Tim McManus came as a complete shock to fans. Stoutland has coached Philadelphia’s offensive line since 2013. During his tenure, he’s played a key role in developing […] The post Jeff Stoutland’s Eagles Departure Signals Major Organizational Changes appeared first on The Lead.
How one man turned peanut butter and jelly into a successful business
Jeremiah Burns pursued a crazy idea. Just when it appeared a dream had died, a desperate prayer was answered.
Snakes keep evolving into cannibals — here's what scientists think is going on
A review of over 500 reports of cannibalistic behavior in snakes finds it's appeared multiple times in different evolutionary lineages, leading researchers to hypothesize it's beneficial for snakes under certain circumstances.
Read the memo: Wasserman says he's selling firm after Epstein fallout
Casey Wasserman, the high-profile talent agent, told his staff on Friday that he was selling the company after his name appeared in the Epstein files.
Penguins Deja Vu — A Similar Script, Two Decades Later
History does repeat itself, and Pittsburgh Penguins fans have seen the scenarios of the 2025-26 season play out before. But […] The post Penguins Deja Vu — A Similar Script, Two Decades Later appeared first on Pittsburgh Hockey Now.
49ers RB Christian McCaffrey reveals hilarious potential nickname
San Francisco 49ers running back Christian McCaffrey appeared on the "Bussin' with the Boys" and debuted a nickname that could stick.
Guns and mental health struggles. What the apparent online footprint of the Canada school shooter tells us
The suspect in Canada’s Tumbler Ridge mass shooting posted about guns and hunting on her YouTube channel and appeared to have written about her struggles with mental health online, according to social media posts.
Are Steelers Done with Trenches Rebuild?
The Pittsburgh Steelers spent the first three draft classes under general manager Omar Khan and assistant general manager Andy Weidl […] This article originally appeared on Steelers Now: Are Steelers Done with Trenches Rebuild? | Locked On Steelers
Seahawks vs. Patriots Super Bowl LX Top Storylines
Super Bowl LX brings together two franchises shaped by history. The Seattle Seahawks and New England Patriots arrive from very different paths, meeting on the same stage with something to prove. While this Super Bowl matchup happened relatively recently in 2014 and became an instant classic, only the fanbases remain since then. Russell Wilson, Pete […] The post Seahawks vs. Patriots Super Bowl LX Top Storylines appeared first on The Lead.
Trump tried to gut science research funding. Courts and Congress have rebuffed him.
A year ago, federal support for scientific research appeared to be crumbling. But thanks to Congress and several lawsuits, scientists’ worst fears haven’t come to pass.
6 NFL Teams Should Hunt for New Quarterbacks in 2026
In his first season with the Seattle Seahawks, Sam Darnold threw for over 4,000 passing yards and led them to the franchise’s first NFC Championship since 2014. Over in Foxborough, Drake Maye racked up 4,200 yards and 30 scores to lead New England to 13 wins in just his second season, leading many to believe […] The post 6 NFL Teams Should Hunt for New Quarterbacks in 2026 appeared first on The Lead.
Elon Musk Calls Billie Eilish ‘Hypocrite’ Over Grammys Speech
Elon Musk weighed in on Billie Eilish’s controversial Grammy Awards speech, where she denounced ICE and declared “F*** ICE” on stage. The tech billionaire responded publicly, sparking fresh debate over the singer’s political activism and past comments. Elon Musk calls out Billie Eilish over her speech At the 2026 Grammy Awards, Billie Eilish used her […] The post Elon Musk Calls Billie Eilish ‘Hypocrite’ Over Grammys Speech appeared first on Reality Tea.
Google’s new ‘Desktop Camera’ app gives us a new peek at Android on the desktop
While we all continue to speculate on the long-term convergence of ChromeOS and Android, a new piece of the puzzle has quietly appeared on the Play Store. Thanks to a cool find by 9to5 Google, we...
Feeling sick? Bad flu season gets worse as a 'second peak' looms.
Cases across the country had appeared to decline before new public health data showed upticks in infections.
Fraud followed by ICE has upheaved election-year politics in Minnesota
Republicans appeared poised for a political resurgence, then January happened.
A mystery vending machine appeared at Pentagon. Then it vanished.
A mystery vending machine at the Pentagon appeared selling collectibles before being removed for review.
From a recalibration in Minnesota to an Epstein files release: Inside the Trump administration’s chaotic week
For a brief moment following the fatal shooting of Alex Pretti, President Donald Trump appeared to recalibrate.
Montana businesses close, shift operations to participate in national strike over ICE activities
Participation appeared to be focused around Missoula, Bozeman and Helena.
A 65km hike into Norway's vanishing rural past
The Stølstruta offers hikers a responsible, respectful way to witness a pastoral tradition that has disappeared almost everywhere else in Europe.
Illinois overscomes clunky start, extends winning streak to 10
CHAMPAIGN — Illinois freshman sensation Keaton Wagler was welcomed with an especially loud cheer from the State Farm Center crowd as he was introduced on Thursday night. And for a microscopic moment, it appeared history could continue to follow him as he was the only Illini to score points through the first six-plus minutes of […]
ROSÉ Is Hitting the Grammy Stage for the First Time
First-time Grammy nominee ROSÉ is set to take the stage at the 2026 Grammys, the event’s organizers announced today. This is a significant milestone in ROSÉ’s solo career. ROSÉ is… The post ROSÉ Is Hitting the Grammy Stage for the First Time appeared first on Where Is The Buzz | Breaking News, Entertainment, Exclusive Interviews & More.
Shaw’s ‘diamond in the rough’ goes from basketball-only to committing to LSU for football
Jackson Williams’ future appeared to be on the basketball court, but a transfer from Newman to Shaw put him on a new path to LSU football. Here’s his story.
Trump Says He Only Appeared to Nod Off in Last Cabinet Meeting Because It Was ‘Boring’
Mr. Trump’s allies have strenuously insisted that he was alert and attentive at the meeting last month. The president said he had only closed his eyes.
Videos emerge of previous confrontation between Alex Pretti and federal officers 11 days before he was killed
On Wednesday The News Movement published a video from 13 January where officers appeared to grab Pretti
Some of ‘Star Search’s’ biggest losers became megastars. Can the revival live up to its past?
Aaliyah, Britney and Beyoncé famously lost when they appeared on “Star Search” back in the day. Those who bested them look back as a new reboot takes off.
Justin Bieber Performance Locked In for Music’s Biggest Night at the 2026 Grammys
Justin Bieber has announced that he will be performing at the 2026 Grammy Awards, which will take place on Sunday, Feb. 1. Bieber is a two-time Grammy winner and also… The post Justin Bieber Performance Locked In for Music’s Biggest Night at the 2026 Grammys appeared first on Where Is The Buzz | Breaking News, Entertainment, Exclusive Interviews & More.
Business groups back freight brokers in Supreme Court trucking liability fight
U.S. Chamber of Commerce, National Retail Federation among those supporting C.H. Robinson in the brief. The post Business groups back freight brokers in Supreme Court trucking liability fight appeared first on FreightWaves.
Broncos, Bills Ache for What Could Have Been
In the wake of the AFC Championship Game, both the Buffalo Bills and Denver Broncos should look at Super Bowl LX as the one that got away. The Broncos fell to the New England Patriots at home in a Rocky Mountain blizzard. The Buffalo Bills were eliminated at Mile High a week earlier and have […] The post Broncos, Bills Ache for What Could Have Been appeared first on The Lead.
How One Business School In Minneapolis Is Navigating The ICE Surge
The University of St. Thomas Opus College of Business campus in downtown Minneapolis, where administrators say students have reported feeling safer on campus than in surrounding neighborhoods amid heightened federal immigration enforcement across ... The post How One Business School In Minneapolis Is Navigating The ICE Surge appeared first on Poets&Quants.
Luminar receives a larger $33 million bid for its lidar business
A new leading bidder has appeared in the Luminar bankruptcy case: Redmond, Washington-based MicroVision, which beat out Quantum Computing Inc.'s bid by $5 million.
Luminar receives a larger $33 million bid for its lidar business
A new leading bidder has appeared in the Luminar bankruptcy case: Redmond, Washington-based MicroVision, which beat out Quantum Computing Inc.'s bid by $5 million.
Galaxy A57 images reveal a shockingly thin frame and lavender hue
Samsung’s Galaxy A57 has appeared on TENAA with a familiar rear camera setup and a new purple color, and it's tipped to be way slimmer.
5 Key Moments from Ways and Means Committee Hearing with Health Insurance CEOs
CEOs of the nation’s largest health insurers and pharmacy benefit managers (PBMs) appeared before the Ways and Means Committee to...
Once high-flying CT restaurant business may shrink in size again sooner than expected. Here’s why.
The development is a stunning contraction of what appeared to be one of Connecticut’s most promising restaurant businesses just two years ago.
Rayman 30th Anniversary Edition has surfaced for Nintendo Switch
A new rating has surfaced for Rayman 30th Anniversary Edition, and it’s apparently on the way to Nintendo Switch. The listing has appeared within the official Australian Classification database. As of now there has been no official announcement. The only information available is that Atari is apparently not only developing, but also publishing. The original Rayman released in 1995. We...
Week in Politics: Trump in Davos; Longtime allies regard the U.S. with reserve
President Trump announced a framework for a deal on U.S. involvement in Greenland, without details, in Switzerland this week. He also appeared increasingly infirm in Davos.
Dallas Cowboys steal promising coach away from Philadelphia Eagles
Dallas Cowboys steal promising coach away from Philadelphia Eagles originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The Dallas Cowboys have stolen a promising coach away from the Philadelphia Eagles.
C.J. Stroud Faces a Defining Offseason in Houston
After overcoming a 0-3 start to make the playoffs, the Houston Texans’ season came to a close on Sunday. The 28-16 loss to the New England Patriots snapped the Texans’ 10-game winning streak. As a result, the Texans remain winless in the Divisional Round. Another poor offensive showing doomed the team, and the lion’s share […] The post C.J. Stroud Faces a Defining Offseason in Houston appeared first on The Lead.
Supreme Court conservatives have downplayed Trump’s conduct. The Fed case may change that
The Supreme Court has gone along for years with President Donald Trump’s unconventional moves and brash legal arguments, as the conservative majority emphasized its regard for the presidency and appeared willing to accept the cost to its own reputation.
The Broncos Can Turn Tragedy into Triumph Against Patriots
As Wil Lutz‘s 23-yard field goal sailed through the uprights to send the Denver Broncos to the AFC Championship, Empower Field turned into a party. While fans rejoiced and Broncos players celebrated, Bo Nix‘s face held a sense of dread. It looked like he knew something no one else did. THE BRONCOS ARE GOING TO […] The post The Broncos Can Turn Tragedy into Triumph Against Patriots appeared first on The Lead.