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The ‘Sacred Science’ has another way to deal with death
The next time someone asks why you’re on your phone so much, tell them you’re just working on your Immortality Project. It’s a concept from cultural anthropologist Ernest Becker’s 1973 book “The Denial of Death,” which posits that most of what humans spend our time on is meant to pretend the inevitable isn’t waiting for […]
ARPA-H to invest $62 million to develop FDA-authorized AI to help treat heart failure
ARPA-H, the government agency that funds cutting edge health research, plans to commit $62.7 million to develop artificial intelligence bots that direct
Stores collecting biometric data in Monroe County must tell customers
Monroe County mandates businesses to post notices when using biometric identification technology, enhancing transparency and protecting consumers.
An onslaught of midterm polling is coming. Here’s how to sort through it
If read carefully, high-quality polls can still tell you a lot about how this year’s midterms are shaping up – and keeping a few simple questions in mind can help you sort through the overwhelming and sometimes overblown deluge of data.
Building a stronger workforce through inclusive hiring
ARC Ontario promotes inclusive hiring in New York to strengthen workforce by employing people with intellectual and developmental disabilities.
Will it kill off humanity? Computer scientists and politicians wrestle with risks of AI
Alarming warnings from industry insiders increase pressure for curbs on artificial superintelligence
Will it kill off humanity? Computer scientists and politicians wrestle with risks of AI
Alarming warnings from industry insiders increase pressure for curbs on artificial superintelligence
CobbleStone® Announces Four Business Solutions Director John O'Brien as Featured Speaker at User Conference 2026
/PRNewswire/ -- CobbleStone Software, a recognized leader in contract lifecycle management (CLM) and contract artificial intelligence, is pleased to announce...
Gracenote Expands AI Product Roadmap with Sports MCP Server, Entertainment SLM and Agents
/PRNewswire/ -- Gracenote, Nielsen's content intelligence business, today unveiled the next phase of its AI product roadmap. Anchored by its Video Model...
EverTrue Acquires Aidentified's Philanthropy Business, Securing Exclusive Data Rights to Advance AI-Powered Fundraising
/PRNewswire/ -- EverTrue, the philanthropy-first intelligence platform for fundraising teams, today announced an exclusive partnership with Aidentified, a data...
H1 acquires Defacto Health to expand provider network intelligence
H1 has acquired Defacto Health, a healthcare data company focused on provider network intelligence, in a move to expand its offerings for health plans and strengthen its healthcare data assets. | H1 has acquired Defacto Health, a healthcare data company focused on provider network intelligence, in a move to expand its offerings for health plans and strengthen its healthcare data assets.
Parlance Brings Verified Push Notification Security to Health System IT Help Desks on ServiceNow Store
/PRNewswire/ -- Parlance, a healthcare voice AI company, today announced the availability of its help desk intelligent virtual assistant (IVA) on the...
BBH Launches a New Technology Business, Braid, Solving for Intelligent Data Transformation
BOSTON, September 09, 2026--Brown Brothers Harriman (BBH) today announced the launch of a new technology affiliate, Braid LLC, focused on solving enterprise data transformation for financial services. Braid offers an AI-native data transformation platform that gives firms a scale solution to transform, connect, and manage their data with confidence.
Indigenous Arts Initiative will offer workshops on arts, entertainment industry
The Indigenous Arts Initiative, which includes partners from the University of Kansas, will bring two distinguished Indigenous artists and educators to Lawrence this September for a series of free public workshops exploring art, culture, storytelling and filmmaking.
AT&T Business and Amazon Leo form strategic partnership
AT&T Business and Amazon Leo have agreed to bring broadband services to AT&T Business customers nationwide, making AT&T is the first major U.S. telecom provider to offer converged connectivity solutions that include Amazon Leo’s low Earth orbit (LEO) satellite services. With the agreement, AT&T Business customers have multiple access connectivity options, which the company said […]
Mac Allister 'spoke brilliantly'
Former Chelsea and Everton winger Pat Nevin says Liverpool midfielder Alexis Mac Allister "said exactly the right things" when telling media that he is "very sad" not to have been offered a new deal by the club. The Argentine, who joined on a five-year contract from Brighton in June 2023, saw team-mates Dominik Szoboszlai and Ryan Gravenberch extend their Reds deals this year. "I often hear various players saying things and pushing things a certain way and you get a bit fed up with it," Nevin told BBC Radio 5 Live's Football Daily podcast.
PROJEKTIL | 10th anniversary & the future of immersive
The founders reflect on a decade of immersive storytelling, from artist collective to international touring studio
Review | Cavalluna’s Hong Kong debut was a magical, if cliché, equine spectacle
Cavalluna’s Asian debut stunned the city with its spectacular horsemanship, but plain and flawed storytelling was a fly in the ointment.
First on CNN: Routine blood testing may hold hidden clues to colorectal cancer before age 45
When you have your blood drawn in a routine doctor’s visit, some of the markers in your blood that get tested could hold unexpected clues to how likely you are to develop colorectal cancer at a young age, new research suggests.
Democrats demand Trump administration halt collection of patients’ ER records
A group of Democratic lawmakers is calling for the Trump administration to suspend a new surveillance program it quietly launched to collect the personal and identifiable health data of Americans who visit emergency rooms.
The wildest sport you’ve never heard of has some unlikely stars: American cowboys
Nine American cowboys joined thousands of global athletes in Kyrgyzstan for the World Nomad Games, competing in Kok-Boru — Central Asia’s ancient, brutal sport of equestrian goat-grabbing.
Turning information into action to strengthen health emergency preparedness in the Eastern Mediterranean Region
WHO and partners advance a new regional All-Hazards Public Health Intelligence (PHI) Network to connect information, anticipate risks and support faster, more coordinated action during health emergencies9 September...
Film and TV Portrayals of A.I. Go Beyond Science Fiction
Plots involving some kind of artificial intelligence are even part of soap operas. Here’s how they’ve evolved over the decades.
‘Fat b*tches’: Videos reveal the extent of GOP candidate’s crude sexual remarks
Brandon Herrera repeatedly made vulgar sexual statements and derogatory comments about the appearance and intelligence of women, CNN found.
After a decade as GOP’s main character, Trump gets one more starring role at midterm convention
For a decade, President Donald Trump has made himself his party’s main character — a singular force around whom its rallies, conventions and political identity have revolved.
How Do Business Owners Really Feel About Influencers? It’s A ‘Love-Hate Relationship’
Four entrepreneurs tell Inc. how they leverage content creators to grow their U.S. brick-and-mortar businesses.
Comviva announces Kalyanasundaram Sivasubramaniam to lead the DigiTech Business, Accelerating Platform-Led Growth and AI Transformation
Comviva, a global leader in digital transformation solutions, today announced the appointment of Kalyanasundaram Sivasubramaniam as Product Unit Head for its DigiTech business. In this role, he will lead the strategic growth and evolution of Comviva's DigiTech portfolio, including its intelligent digital business platform, BlueMarble.
Today’s Papers – Big Inter gifts, Juventus in trouble
La Gazzetta dello SportJuve, you need to get yourself blessed.Locatelli returns in 2027; stop for BogaAfter Yildiz and Thuram, the captain underwent surgery too (could be out for six months)Inter’s ...
The world’s best-paid politician is getting a $1 million pay rise
Singapore’s ministers are already among the world’s highest-paid politicians, with Prime Minister Lawrence Wong earning more than four times US President Donald Trump’s annual government salary.
Slime Molds and a double Ig Nobel Prize winner and a big, great science adventure
” ‘This is dangerous’: slime moulds and the bitter debate over the nature of intelligence — Scientists are battling over whether supposedly simple organisms should be considered ‘intelligent’…
Alleged victim of Alan Jones looked ‘sunken and diminished’, politician tells court
Downing Centre court hears that the alleged victim was usually outgoing but his demeanour changed at a meeting with Jones at his apartment
Trump gave Natalie Harp and two other aides $45,000 each in cash gifts for holidays
President Donald Trump gave Natalie Harp and two other White House aides $45,000 each in cash gifts, according to financial disclosure statements.
49ers defensive lineman Alfred Collins' injury latest blow to largely unproven unit
San Francisco 49ers second-year defensive lineman Alfred Collins tore his patellar tendon at the team's second practice in Melbourne and will be out for the season, coach Kyle Shanahan said.
Colorado students report bullying, threats, mental health concerns as school year begins
Colorado’s Safe2Tell system received more than 1,500 reports in August, including bullying, threats, mental health concerns and a case involving an AI-generated explicit image.
Allegheny County Council proposes bill that could regulate AI use in political campaign materials
Members of Allegheny County Council on Tuesday introduced a bill that would require political candidates to disclose their use of artificial intelligence in campaign materials, an effort aimed at preventing voters from being misled by AI-generative content. If passed, the ordinance would establish disclosure requirements for AI-generated campaign content used
Taylor Swift Promoter Tells Judge Live Nationr Could Kill His Business
Louis Messina, tour promoter for Taylor Swift's Eras Tour as well as Ed Sheeran and other top acts, told a judge Live Nation has harmed his business.
The Trump administration slams Ford for its ties to China
The Trump administration on Tuesday expressed “profound concern” to carmaker Ford about its alleged ties to Chinese technology and manufacturing.
Pat Fitzgerald Tells Spartans Playing Time Starts in Practice
Pat Fitzgerald told Michigan State that playing time is earned in practice, not on Saturdays. #GoGreen
Rep. Chris Pappas will face former Sen. John E. Sununu in New Hampshire Senate race, CNN projects
Democratic Rep. Chris Pappas will face Republican former Sen. John E. Sununu in the race for New Hampshire’s open Senate seat, CNN’s Decision Desk projects.
Why General AI Coding Assistants Fall Short in Science
Generic AI coding assistants struggle with scientific workflows. Rolv v3 adds reproducibility, biomedical intelligence, HPC execution, and visual DAGs.
A study links prenatal acetaminophen with reproductive changes in girls. Doctors say it remains safe to use when needed
A new study found that some girls born to mothers who took acetaminophen during pregnancy developed reproductive organ changes that could affect fertility later in life. It’s a finding the study authors say should drive future research but shouldn’t yet change how certain symptoms are treated during pregnancy.
Not hitting your step goal? Pick up the pace
Walking at a brisker pace may lower the risk of early death, even for people who don’t reach high daily step counts, a new study found. Here’s what experts recommend.
Live results: Delaware primary election
See Delaware election results and maps for the 2026 primaries.
Live results: Rhode Island primary election
See Rhode Island election results and maps for the 2026 primaries.
Live results: New Hampshire primary election
See New Hampshire election results and maps for the 2026 primaries.
Supreme Court rejects Missouri’s request to use congressional map with extra GOP seat
The Supreme Court on Tuesday denied Missouri’s request to use a congressional map for the November midterm election that would have given Republicans a chance to flip a seat, a rare setback for the GOP’s effort to keep control of the House next year by eking out an advantage from its political boundaries.
Dolly Parton's sister slams 'fake AI garbage' following icon's death
In a Sept. 4 Instagram statement, Dolly Parton's sister Stella Parton thanked fans for the “genuine” support, urging supporters to use her sister’s life as an “example for tolerance and respect towards others.”
US targets multiple Iranian tankers near Kharg Island
The US targeted multiple Iranian tankers near Kharg Island in the Strait of Hormuz on Tuesday, according to two US officials.
Trump Tells Weird Lie About Where He Was on 9/11
At an event honoring first responders, Trump claimed he was carried away from Ground Zero by firefighters, which didn’t happen.
988: September 8 marks nationwide awareness campaign for mental health crisis lifeline
Georgians are being asked to tell a friend about 988 as part of a nationwide campaign marking September 8.
AT&T Business Expands Work with Amazon Leo for Resilient Connectivity
AT&T Business has furthered its agreement with Amazon’s Amazon Leo constellation to offer “converged connectivity solutions” integrating satellite
Eutelsat Wins Further Connectivity Business in Greenland
Eutelsat is going to help to bring better connectivity to Greenland. Alongside the European Union, the government of Greenland and the government of
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
“Furious” creator breaks down season 1 finale and teases what’s next for Alice
“I’m definitely not using the show as a platform to advocate murdering people,” Meriwether tells EW.
Andy Serkis’ ‘Nevatars’ Brings a New Kind of Storytelling to Venice Immersive
Andy Serkis' Nevatars brings interactive XR storytelling, alongside ambitious projects featuring Margot Robbie, Omar Sy and Mark Ruffalo.
Roundup: Using AI to better integrate virtual modalities into care delivery
Artificial intelligence enhancements in telehealth aim to bolster care continuity while virtual nursing extends bedside care. Also, Zocdoc integrates with Google Gemini to book appointments while Sword Health is set to acquire Headspace's parent company.
Trump honors 9/11 first responders — and plugs his political priorities
President Donald Trump on Tuesday honored the heroes of the September 11, 2001, terror attacks — but couldn’t resist mentioning the Iran war and communism.
Harvard, MIT scholars head north as Carney offers millions
Canada is investing $362 million to lure 64 top global scholars, including dozens from Harvard, MIT and other elite U.S. universities, to advance research in health and artificial intelligence.
OpenAI Says It Has Cracked One of Math’s ‘Millennium Problems’
The company’s announcement is the most dramatic sign yet that artificial intelligence is fundamentally transforming the field of higher mathematics.
Telluride 2026: The 6 best movies we saw at the film festival
Some major Oscar contenders were forged, notably Andrew Scott and Julianne Moore, as the exclusive Colorado film showcase pulled off a successful edition.
Are rich people really worse behaved? Here’s the science
Who’s more likely to steal sweets from a child? According to science, it’s the rich. A study seemingly confirming our suspicions about the moral behaviour of the wealthy was one of the winners of the 2026 Ig Nobel prizes, which honour research that makes you laugh and then think. Science editor Ian Sample tells Madeleine Finlay what the researchers think could be behind the phenomenon, and they explore some of the other awards, including one for a surprising quality we look for in our friends and another for a biomechanical definition of kissing
Smithsonian head Lonnie Bunch to retire amid Trump administration effort to reshape institution
Lonnie Bunch III said Tuesday that he will retire as the head of the Smithsonian Institution, a role that placed him at the center of President Donald Trump’s efforts to reshape the world’s largest museum organization.
29 More Days Isn't a Business Plan (Opinion)
The one-month reprieve on the impending ban on many hemp products doesn't give small businesses enough time to make the decisions required to keep their companies running. Dylan Raap, CEO and founder of cannabis and hemp business Upstate Elevator, asks Congress to ‘tell us what the rules are and give us enough runway to live by them.’
US targets Iran’s airline industry as part of pressure campaign
The Trump administration took sweeping actions against Iran’s airline industry on Tuesday as part of its pressure campaign on Tehran.
Rams-49ers final score prediction: Who you picking?
Tell us you think will win on Thursday!
Nevada SBDC bringing hands-on AI training to Reno small businesses
Reno entrepreneurs will get a chance to explore practical ways artificial intelligence can help their businesses.
Names in the News 9-8-26
Appointments and promotions at Constellation Hotels, Emirates, Virgin Atlantic and Hilton
Former Kane Realty COO launches AI-powered real estate consulting firm
Bonner Gaylord and David Shaner co-founded Grounded Intelligence to help Triangle commercial real estate firms implement AI tools for competitive advantage.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Auburn launches new AI course for business leaders in Birmingham
As AI (artificial intelligence) becomes increasingly integrated into our everyday lives, it's transforming everything from the way we search for information
BUSINESS Katie Scheuber showcases their unique storytelling with Stay Tuned Productions
Almost 12 years ago, nonbinary lesbian Chicago documentary filmmaker and photographer Katie Scheuber created Katie Makes Films video, a production company to showcasing their love of visual storytelling, while still working as a social worker. In 2022, Scheuber’s wife Noemi Heras encouraged them to do the video work full time. Last year Scheuber created Stay Tuned […]
Memorial Hermann Health System Clinicians Use Epic's AI Tool to Help Patients Better Understand Test Results
/PRNewswire/ -- Clinicians at Memorial Hermann Health System (MHHS) are using a new artificial intelligence (AI) tool built directly into Epic to help patients...
Jensen Huang’s AGI Claim Is A Business Case, Not Settled Fact
Jensen Huang says AGI has arrived, but the claim reflects AI’s business value more than proof of human-level, general-purpose intelligence.
Straight-Six-Powered BMW M350 Promises 440 HP and a Drift Mode: TDS
Also, Stellantis has expanded an already massive Jeep Grand Cherokee suspension recall, and the new Audi A2 is an EV we'll be sad to miss out on.
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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