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Detroit Lions vs. Minnesota Vikings Point Spread Revealed

The Detroit Lions are 3-point favorites against the undefeated Minnesota Vikings in Week 8. See the latest FanDuel point spread, moneyline, and total.

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Oct 25 • 8:18 PM EDT • Sports • sports.yahoo.com
Windows 11’s new “better performance” toggle shows up, but your current PC will never be able to use it

Windows 11's recent preview builds include a new toggle called "Advanced Performance Extensions," aka "APX," and on supported hardware.

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Oct 25 • 8:15 PM EDT • Technology • windowslatest.com
Johnson County Focus on Youth Fund promotes access to children’s mental health resources

This is an installment of a series exploring youth mental health. The Daily Iowan has received a grant and is partnering with the Solutions Journalism Network to explore the topic. The Johnson County Focus on Youth Fund has been promoting access to children’s mental health resources by providing funding for families who can’t afford services....

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Oct 25 • 8:13 PM EDT • Health • dailyiowan.com
Local business expert recommends reporting scams via BBB scam tracker

The Better Business Bureau warned the public about phishing scams and advised consumers to regularly check their bank and credit card statements to identify fraudulent activity.

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Oct 25 • 8:08 PM EDT • Business • yahoo.com
Local business expert recommends reporting scams via BBB scam tracker

The Better Business Bureau warned the public about phishing scams and advised consumers to regularly check their bank and credit card statements to identify fraudulent activity.

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Oct 25 • 8:08 PM EDT • Business • fourstateshomepage.com
Wan'Dale Robinson held to seven yards in Week 7

Tennessee Titans wide receiver Wan'Dale Robinson posted four receptions for just seven yards in Week 7

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Oct 25 • 8:06 PM EDT • Sports • sports.yahoo.com
Chinese scientists discover “D-rex,” a giant fungus with roots stretching back 65 million years

Scientists have discovered a giant new fungus in China that grows up to 20 inches tall and weighs nearly five pounds, making it the largest known of its kind. Dubbed “D-rex,” its evolutionary lineage appears to have emerged shortly after the dinosaurs went extinct, raising intriguing questions about how that ancient catastrophe may have shaped its evolution.

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Oct 25 • 8:00 PM EDT • Science • sciencedaily.com
Scientists discover Arctic sea ice loss could be far worse than predicted

Arctic winter sea ice could disappear much faster than scientists previously expected, according to new research using climate clues from 6,000 years ago. By comparing ancient ocean sediments with modern climate models, researchers found that future winter ice coverage may be roughly one million square kilometers smaller than earlier predictions suggested.

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Oct 25 • 8:00 PM EDT • Science • sciencedaily.com
Tiny magnetic vortices could help computers work more like your brain

Scientists have filmed tiny magnetic vortices called skyrmions melting out of an organized lattice for the first time, revealing new ways to manipulate these unusual structures. The breakthrough could help make brain-like computers a reality, potentially enabling dramatically smaller and more energy-efficient technology.

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Oct 25 • 8:00 PM EDT • Science • sciencedaily.com
UCLA Library's Data Science Center closed amid consolidation effort

UCLA Library dissolved its data consultation center and stopped offering data analysis services in August. The university consolidated the Data Science Center into UCLA Library’s research services unit as part of a broader effort to restructure the department, a UCLA Library spokesperson said in an emailed statement.

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Oct 25 • 8:00 PM EDT • Science • dailybruin.com
Decarbonizing Manufacturing Supply Chains: C-Suite Guide

Decarbonizing manufacturing supply chains guide for executives. Strategic insights on reducing carbon emissions while driving business growth.

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Oct 25 • 8:00 PM EDT • Business • weforum.org
Young Scientists Congress: New technologies take centerstage at science exhibition in Wenzhou

The World Young Scientists Congress has opened in Wenzhou, east China's Zhejiang Province. More than 800 scientists and entrepreneurs from over 60 countries and regions are attending the event which includes an exhibition of the latest technologies. We spoke with some of the visitors to the event.

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Oct 25 • 8:00 PM EDT • Science • news.cgtn.com
Probi and Symrise spotlight new clinical evidence at SupplySide Global

At SupplySide Global 2026, Symrise and Probi present new clinical findings for skin radiance and digestive health alongside a stable probiotic designed to broaden formulation options for brands

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Oct 25 • 8:00 PM EDT • Health • nutraceuticalbusinessreview.com
"Tomb Raider: Legacy of Atlantis" 30th Anniversary Trailer

A new trailer is out for “Tomb Raider: Legacy of Atlantis,” the reimagining of the original 1996 first “Tomb Raider” game. Created in Unreal Engine 5, it offers fresh visuals, skill trees, and an expanded Atlantis story that will tie in the various eras of Lara Croft together. As Lara, harness your wits and athleticism […]

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Oct 25 • 7:48 PM EDT • Technology • darkhorizons.com
Lions beat Packers 20-17 on last-play field goal
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Oct 25 • 7:46 PM EDT • Sports • sports.yahoo.com
Zelenskyy says Putin’s statements on readiness for peace talks could be a ‘political trick’

Ukrainian president argues Russian intentions would become clear through its actions, readiness to reach agreements | Anadolu

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Oct 25 • 7:38 PM EDT • Politics • aa.com.tr
Thousands protest in Prague against public media funding reforms

Demonstrators allege Prime Minister Andrej Babis and his coalition's proposed reforms pose a threat to press freedom.

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Oct 25 • 7:29 PM EDT • Politics • aljazeera.com
Vucic Concedes Electoral Defeat, Setting Stage For New Era Of Serbian Politics, Relations With West

Aleksandar Vucic, Serbia's former president and dominant political figure for more than a decade, conceded defeat to the student-led protest movement in the country's parliamentary elections, potentially ushering in a new era of politics more closely aligned with Europe and away from the Kremlin.

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Oct 25 • 7:15 PM EDT • Politics • rferl.org
😐 Neutral (17%)
Kyle Larson’s Championship Moment Comes at Talladega

Conquering his drafting-track demons, Larson surged from mid-pack chaos to secure a historic Hendrick 1-2 finish, building a massive points cushion that places the title within reach

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Oct 25 • 7:08 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Denzel Boston quiet in Week 7 road win vs. Titans

Cleveland Browns wide receiver Denzel Boston registered three receptions for 27 yards on eight targets in Week 7

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Oct 25 • 7:07 PM EDT • Sports • sports.yahoo.com
🙂 Positive (40%)
love
100%
9th Circuit panel questions basis for feds' request to block 20,000 California ballots

Two judges questioned the Justice Department's lawyer about how the Trump administration's position squared with the law.

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Oct 25 • 6:54 PM EDT • Politics • latimes.com
Xbox console users will receive 50 games from October 26 to 31.

From October 26th to 31st, the Xbox ecosystem and Xbox PC service will receive a major expansion of their catalog, including the release of 50 new games for...

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Oct 25 • 6:40 PM EDT • Technology • en.gamegpu.com
Isaiah Likely disappoints in Week 7 vs. Texans

New York Giants tight end Isaiah Likely limited to two receptions for 12 yards on four targets in Week 7

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Oct 25 • 6:32 PM EDT • Sports • sports.yahoo.com
Susan MacManus sees working class voters continuing to change Florida's landscape

NPA voters could act differently than in prior pst-pandemic elections.

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Oct 25 • 6:30 PM EDT • Politics • floridapolitics.com
Pistons' Ausar Thompson ruled out against Sixers

The Pistons will be without Ausar Thompson on Sunday night for their match against Philadelphia.

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Oct 25 • 6:22 PM EDT • Sports • sports.yahoo.com
Absent Vinícius Jr. ‘laughs’ at Barcelona after Real Madrid victory

Real Madrid star Vinícius Jr. has on Sunday evening taken to social media, to issue his response to his side’s victory over arch rivals Barcelona.José Mourinho’s troops made the trip to the Spo...

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Oct 25 • 6:20 PM EDT • Sports • sports.yahoo.com
49ers' First Loss Makes It Clear: Their Toughest Opponent Is Their Health

The 49ers picked up their first loss of the season on Sunday, but it wasn't what the Falcons did that caused them to stumble.

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Oct 25 • 6:11 PM EDT • Health • foxsports.com
MedStar Health expert warns parents about illnesses affecting teens and college students

CBS News Baltimore spoke with an expert at MedStar Health about common illnesses among teens and college students, including mononucleosis, strep throat and skin infections.

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Oct 25 • 6:08 PM EDT • Health • cbsnews.com
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Jaylin Noel goes backward in Week 7 vs. Giants

Houston Texans wide receiver Jaylin Noel posted two receptions for minus-3 yards on two targets in Week 7

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Oct 25 • 6:04 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
After testing all major mobile browsers, this one finally earned my default spot

Looking beyond Chrome paid off with the best browser experience

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Oct 25 • 6:00 PM EDT • Technology • androidpolice.com
Packers defensive tackle Devonte Wyatt questionable to return after injury

Green Bay Packers defensive tackle Devonte Wyatt questionable to return after injury vs. Detroit Lions.

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Oct 25 • 5:52 PM EDT • Sports • sports.yahoo.com
Nico Collins disappoints in Week 7 vs. Giants

Houston Texans wide receiver Nico Collins posted two receptions for six yards on five targets in Week 7

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Oct 25 • 5:50 PM EDT • Sports • sports.yahoo.com
Peoria business leader accused of DUI in deadly UTV crash

A business executive well known in the local sport community has been arrested on drunk driving accusations for a crash that killed a woman late Saturday night in rural Peoria County.

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Oct 25 • 5:48 PM EDT • Business • 25newsnow.com
Dalton Schultz totals five receptions in Week 7

Houston Texans tight end Dalton Schultz posted team highs with five receptions, 45 yards and six targets in Week 7

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Oct 25 • 5:43 PM EDT • Sports • sports.yahoo.com
Missile makers see multi-year deals as politics-proof

Executives at the military’s biggest suppliers say the Pentagon’s new multi-year munitions deals are the surest way to navigate an uncertain funding climate.

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Oct 25 • 5:34 PM EDT • Politics • punchbowl.news
Novant Health hosting Hilton Head hiring event Oct. 28

Novant Health will host a healthcare hiring event Oct. 28 on Hilton Head Island for nursing, laboratory, pharmacy and other positions.

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Oct 25 • 5:22 PM EDT • Health • wtoc.com
😐 Neutral (2%)
love
100%
C.J. Stroud tosses two TDs in Week 7

Houston Texans quarterback C.J. Stroud completed 17 of 28 passes for 153 yards, two touchdowns and no interceptions in Week 7

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Oct 25 • 5:15 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
wow
100%
Clemson’s Loss to Virginia Tech Puts the Program in Flux

Clemson’s loss to Virginia Tech puts the program in flux heading into November. The Tigers now find themselves on the outside looking in on the ACC Championship race after being defeated 20-16 by the Hokies. Dabo Swinney’s team played well in many spots, especially in the third quarter. The complementary football Clemson displayed to start the …

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Oct 25 • 5:05 PM EDT • Sports • sports.yahoo.com
British Columbia's new premier lucks into the job in unexpected political turn

An electoral gamble by the Canadian province's outgoing premier, David Eby, backfired as the provincial Conservatives take power for the first time since 1928.

yahoo.com logo
Oct 25 • 4:58 PM EDT • Politics • yahoo.com
BC's new premier lucked into the job in an unexpected political turn

An electoral gamble by the Canadian province's outgoing premier, David Eby, backfired as the provincial Conservatives take power for the first time since 1928.

bbc.com logo
Oct 25 • 4:58 PM EDT • Politics • bbc.com
T.J. Hockenson finds end zone in Week 7 vs. Colts

Minnesota Vikings tight end T.J. Hockenson posted four receptions for 35 yards and a touchdown on five targets in Week 7

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Oct 25 • 4:51 PM EDT • Sports • sports.yahoo.com
Vučić concedes defeat in Serbian elections, says student movement won

The election was seen as a referendum on Vučić’s political dominance and the political system that has been in place in Serbia for more than a decade.

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Oct 25 • 4:51 PM EDT • Politics • euronews.com
Presidential race in Bulgaria heads to runoff due to record low turnout

In a surprisingly strong performance, the candidate of the pro-Western reformist opposition, Andrey Gyurov, will face the incumbent leftist president, Iliana Yotova, setting clear lines of division regarding the country’s future relationships with other nations.

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Oct 25 • 4:39 PM EDT • Politics • pbs.org
Justin Jefferson limited to 44 yards in Week 7

Minnesota Vikings wide receiver Justin Jefferson had four receptions for a team-high 44 yards on seven targets in Week 7

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Oct 25 • 4:38 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-7%)
Four receptions for Chris Godwin Jr.

Buccaneers WR Chris Godwin Jr. leads team with four receptions in Week 7 win

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Oct 25 • 4:31 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Kyler Murray throws for 150 yards, TD in Week 7

Minnesota Vikings quarterback Kyler Murray completed 14 of 24 passes for 150 yards, one touchdown and no interceptions in Week 7

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Oct 25 • 4:16 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Michigan basketball gets reality check in exhibition loss vs Houston

Michigan writer Tony Garcia offers three observations from the Wolverines' 83-66 loss to Houston in its final exhibition.

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Oct 25 • 3:42 PM EDT • Sports • sports.yahoo.com
Primark's Business Doesn't Make Sense

In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot

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Oct 25 • 3:31 PM EDT • Business • finance.yahoo.com
Utah business, government leaders deepen connections in Ireland

Utah Gov. Spencer Cox met with Irish Prime Minister Micheál Martin on Wednesday amid a trade mission organized by World Trade Center Utah.

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Oct 25 • 3:30 PM EDT • Business • ksl.com
Science 4 Everyone: How does sod and tall fescue work?

Science teacher and Storm Team4 Meteorologist Ryan Miller explains how to use sod in your yard to prepare for cooler weather.

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Oct 25 • 3:27 PM EDT • Science • nbcwashington.com
The Politics of Heaven ~ The Imaginative Conservative

The key to understanding Thomas More’s generous dedication to the real but limited good he could do on earth is, as Frank Mitjans makes clear, that More’s constant contemplation of God was the source of his boundless care for the souls surrounding him. Thomas More’s Vocation, by Frank Mitjans

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Oct 25 • 3:20 PM EDT • Politics • theimaginativeconservative.org
NZ’s hidden chronic health burden is even bigger than we thought

New research reveals a major gap in how chronic illness is measured, with implications for planning and funding healthcare in New Zealand.

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Oct 25 • 3:10 PM EDT • Health • theconversation.com
USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again

Both the USC Trojans and the UCLA Bruins had their rankings in the Associated Press Top 25 poll following their results from Saturday. View this post on Instagram A post shared by LA Sports Report (@lasportsreport) What Happened to USC’s Ranking? Following their loss to Wisconsin on Saturday, USC dropped out of the Top 25. […] The post USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again appeared first on LA Sports Report.

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Oct 25 • 3:07 PM EDT • Sports • sports.yahoo.com
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center

The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.

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Oct 25 • 3:00 PM EDT • Health • loudountimes.com
Halloween evolved as a Frankenstein of cultural celebrations

The holiday has origins in Celtic, Roman and Catholic festivals and feasts, and mixed with other traditions as it spread.

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Oct 25 • 3:00 PM EDT • Entertainment • theshorthorn.com
Lions Week 7 inactives: EDGE Ahmed Hassanein OUT vs. Packers
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Oct 25 • 2:59 PM EDT • Sports • sports.yahoo.com
Trump’s Election Attacks Enter New Pre-emptive Phase

A lawsuit by the Justice Department challenging a potential narrow loss by the GOP Senate incumbent in Alaska reflects a new tactic by the president to try to shape the election results.

nytimes.com logo
Oct 25 • 2:42 PM EDT • Politics • nytimes.com
Board of Deputies of British Jews declares Greens to be racist party

The Jewish body's vote comes in response to the Green Party passing a "Zionism is racism" policy motion.

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Oct 25 • 2:05 PM EDT • Politics • bbc.com
Olympiacos May Attempt to Sign Genoa Midfield Maestro This Winter

Olympiacos are poised to reignite their pursuit of Morten Frendrup, testing Genoa's resolve after a rejected summer bid for the consistent Danish engine room specialist.

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Oct 25 • 2:01 PM EDT • Sports • sports.yahoo.com
Navigating D1 pressure: how student-athletes balance their mental health

Mental health affects everyone, including athletes who have a really good way of hiding it. Research shows that mental health issues affect roughly 39-44% of Division I athletes. Behind game day, good game performance, and navigating life in college, D1 athletes are constantly trying to balance high expectations with their own well-being. It’s not...

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Oct 25 • 1:59 PM EDT • Health • nmsuroundup.com
Three receptions for Germie Bernard

Steelers WR Germie Bernard catches three of his five targets in Week 7 win

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Oct 25 • 1:40 PM EDT • Sports • sports.yahoo.com
Chris Olave targeted 10 times in Week 7

New Orleans wide receiver Chris Olave went for six receptions for 56 yards on 10 targets in Week 7

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Oct 25 • 1:33 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
COMMENTARY: Three reasons why Tennessee football imploded against South Carolina

Penalties, brain blips and a hangover conspire to doom Volunteers.

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Oct 25 • 1:33 PM EDT • Sports • sports.yahoo.com
Schefter: Seahawks among teams ‘expected to consider’ Jonathan Taylor trade

The Seahawks are “pondering” adding Taylor in hopes of saving their run game.

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Oct 25 • 1:32 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-10%)
Projections for Cleveland Guardians’ Arbitration Eligible Players

The Cleveland Guardians have several key players arbitration-eligible this offseason.

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Oct 25 • 1:30 PM EDT • Sports • sports.yahoo.com
Union County Best of the Best Business of the Year Magnolia Renovations Joshua Andrews, owner

What was your reaction when you learned your business had been named Business of the Year?

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Oct 25 • 1:19 PM EDT • Business • djournal.com
😐 Neutral (0%)
How To Build A Cheap Home Server To Save Money On Subscriptions

You can turn an old laptop, a computer, or even a Raspberry Pi into a cheap media server, but it's best to run a Linux distribution for maximum compatibility.

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Oct 25 • 1:17 PM EDT • Technology • bgr.com
Clatsop County health inspections for September

Clatsop County health inspectors recently completed a round of restaurant inspections that yielded overwhelmingly positive results for most local eateries. But one Seaside establishment received a temporary closure after receiving […]

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Oct 25 • 1:10 PM EDT • Health • dailyastorian.com
Hunter's Moon 2026: All About October's Full Moon And What To Expect Tonight

The title "Hunter's Moon" dates back generations, originating in the Northern Hemisphere because it typically follows the harvest season.

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Oct 25 • 1:09 PM EDT • Science • ndtv.com
Argentina Folk Sounds, Controversy: Milo J, Cazzu, Broke Carey

Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside and sharing their history with the world.

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Oct 25 • 1:09 PM EDT • Politics • rollingstone.com
How Argentina’s Folk Sounds Are Shaping a Generation’s Politics and National Pride

Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside, staving off pop homogenization and sharing their history with the world

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Oct 25 • 1:09 PM EDT • Politics • yahoo.com
Senate rivals seek support from Alaska Native voters

The major candidates in Alaska’s U.S. Senate race are both casting themselves as strong voices on Alaska Native issues as they seek support from the key constituency ahead of the Nov. 3 election

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Oct 25 • 1:03 PM EDT • Politics • latimes.com
3 Cubs Who Will Decline Their Options
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Oct 25 • 1:01 PM EDT • Sports • sports.yahoo.com
'Sound of Music' star Julie Andrews spotted in rare Hamptons outing weeks after turning 91

Julie Andrews, 91, was photographed in the Hamptons wearing a purple raincoat and pink sunglasses in a rare public outing in the coastal city.

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Oct 25 • 1:00 PM EDT • Entertainment • yahoo.com
'Not a one-person job:' Bernardsville explores exit from Bernards Health Department

BERNARDSVILLE - Concerns about costs have led borough officials to consider cutting off decades-long services from the Bernards Township Health Department and switching to the Somerset County Health Department.

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Oct 25 • 12:27 PM EDT • Health • newjerseyhills.com
Photographer and medical professionals connect science and art during panel discussion

In 2020, the world was put on hold because COVID-19 began claiming the lives of people all over the globe. When a vaccination for the illness was finally made public in 2021, being vaccinated became highly politicized. Instead of focusing on the emotional reactions that people had toward the vaccine, artist Linda Alterwitz was more...

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Oct 25 • 12:14 PM EDT • Science • thesunflower.com
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Bloomington business continues to blossom

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Oct 25 • 12:11 PM EDT • Business • insideindianabusiness.com
😐 Neutral (0%)
3 comments | Progressive Democrats are closely watching four Senate...

Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.

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Oct 25 • 12:07 PM EDT • Politics • facebook.com
😐 Neutral (0%)
How the conservative Supreme Court has rewritten the rules for the midterms

Voters will pick the winners of next month’s midterm elections, but it is the conservative Supreme Court that has set the rules.

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Oct 25 • 12:00 PM EDT • Politics • cnn.com
Is having urine the color of Mountain Dew normal?

A Trump administration doctor says neon yellow urine is normal because of diets consisting entirely of meat and fermented foods. Here’s what experts say

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Oct 25 • 12:00 PM EDT • Health • health.yahoo.com
😐 Neutral (12%)
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57%
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43%
Political cartoons for October 25

Sunday's political cartoons include increasing costs, the White House briefing room, and more

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Oct 25 • 12:00 PM EDT • Politics • theweek.com
Blue Ivy takes the stage, Destiny’s Child reunites at Jay-Z’s L.A. concert

Blue Ivy Carter joined dad Jay-Z onstage for a piano accompaniment, while mom Beyoncé cheered her on with two very special guests.

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Oct 25 • 11:59 AM EDT • Entertainment • ew.com
Connections: Law firms hire attorneys for NWA offices

Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...

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Oct 25 • 11:50 AM EDT • Politics • talkbusiness.net
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Connections: Law firms hire attorneys for NWA offices

Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...

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Oct 25 • 11:50 AM EDT • Business • talkbusiness.net
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Selena Gomez's vaping admission highlights hidden health risks doctors say millions face daily

Selena Gomez called vaping "stupid" after it altered her voice, but doctors warn the health risks go beyond vocal cord damage for millions.

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Oct 25 • 11:48 AM EDT • Health • foxnews.com
Cost of employer-sponsored health insurance rises again, survey finds

WASHINGTON — The cost of employer-sponsored health insurance increased again this year, as did the deductibles many people must pay before their plans begin covering most health care expenses, according

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Oct 25 • 11:40 AM EDT • Health • chronicleonline.com
Packers Lose Defensive Captain Just Before Massive Showdown With Lions

Green Bay Packers defensive captain Zaire Franklin has been ruled out against the Detroit Lions, leaving Green Bay without both starting linebackers.

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Oct 25 • 11:35 AM EDT • Sports • sports.yahoo.com
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ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Jennifer Hawks explains why she should be California's State Treasurer

Jennifer Hawks, a candidate for California state treasurer, shared her qualifications and vision for the office in an interview on California Politics 360.

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Oct 25 • 11:25 AM EDT • Politics • kcra.com
Senator, former California Secretary of State Alex Padilla weighs in on voter roll fight

With one week left before the midterm elections, California is facing a federal lawsuit alleging that non-citizens were registered to vote, received mail-in ballots, and, in some cases, voted.

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Oct 25 • 11:25 AM EDT • Politics • kcra.com
California election officials frustrated, rattled by DOJ demand to sequester 'noncitizen' ballots

The administration has insisted that immigrants voting is a major problem nationwide, when in fact it is quite rare, as even its own investigations have shown.

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Oct 25 • 11:17 AM EDT • Politics • pbs.org
Syria’s Democratic Transition: Building Institutions Alongside Political Competition

Syria’s post-Assad transition has revived debate over when to legalize political parties. Parties are essential to political competition,

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Oct 25 • 11:16 AM EDT • Politics • fairobserver.com
Postpartum recovery window may play a critical role in maternal aging and long-term health

In many studies, it appears that women who have more children have a higher risk of heart disease and a shorter life span, but this effect is inconsistent across populations and no good explanation for ...

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Oct 25 • 11:00 AM EDT • Health • medicalxpress.com
Campbell County health and food inspections (10/16/26–10/22/26)

GILLETTE, Wyo. — The Consumer Health Services Division of the Wyoming Department of Agriculture conducts inspections of retail food establishments throughout Wyoming (where there is not a local health department that does inspections) to help ensure safety of Wyoming residents. Campbell County establishments are inspected at least once a year by the WDA. All of […]

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Oct 25 • 11:00 AM EDT • Health • county17.com
Laramie County health and food inspections (10/16/26–10/22/26)

CHEYENNE, Wyo. — The Cheyenne-Laramie County Health Department inspects restaurants, bars, convenience stores, delis, grocery stores, bed and breakfasts

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Oct 25 • 11:00 AM EDT • Health • capcity.news
Natrona County health and food inspections (10/16/26–10/22/26)

CASPER, Wyo. — The Casper-Natrona County Health Department inspects restaurants, grocery stores, convenience stores, mobile food units, commissaries and

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Oct 25 • 11:00 AM EDT • Health • oilcity.news
GeForce Unlocked: Modders Boost RTX 20, RTX 30, and RTX 40 Compute Performance by Up to 2x

NVIDIA's GeForce RTX 30-series and RTX 40-series graphics cards are based on the same dies as their professional-grade GPUs. This means the compute potential of consumer-oriented RTX GPUs is restricted by NVIDIA's firmware stack, but modders have managed to unlock the instruction issuing rate...

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Oct 25 • 10:43 AM EDT • Technology • techpowerup.com
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign

Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.

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Oct 25 • 10:35 AM EDT • Politics • pbs.org
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say

A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…

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Oct 25 • 10:20 AM EDT • Business • pilotonline.com
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean

Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...

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Oct 25 • 10:08 AM EDT • Health • finance.yahoo.com