SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " mari " 3,259 found 🔀 AI-powered Shuffle
Athletics vs. Seattle Mariners - Live Score
View the Athletics vs. Seattle Mariners game played on September 03, 2026. Box score, stats, play-by-play timeline, highlights, odds & more
Skeleton of massive blue whale expected to make final migration to Hatfield Marine Science Center in May
If all goes as planned, the skeleton — after help from scientists and specialists from around the world — will be fully reassembled in May outside the Hatfield Marine Science Center in Newport, completing a journey from surf to scientific centerpiece.
Canadian business stalls over US trade deal jitters
STORY: The Canadian manufacturing hub of Windsor is home to thousands of small and specialized part makers and caters primarily to car companies and equipment manufacturers. The city thrives on close integration with Detroit, America's automotive capital, just across the river.That means it's also on the frontline of tariff and trade uncertainty with Canada's largest trading partner. JACKIE RAYMOND: "Even if we don't directly work with the automotive industry, we indirectly do."Jackie Raymond is co-owner of FASTSIGNS, a Canadian company that designs and installs custom business signs and graphics.The company is coming off its toughest year since the pandemic. Orders from its core automotive clients dried up.And while a new project brought some relief, the company says customers are placing smaller orders, demanding longer payment terms, and bargaining harder on prices.:: FileIt all points to uncertainty tied to the United States-Mexico-Canada Agreement, which is up for review this year. It's a deal U.S. President Donald Trump has repeatedly said he could scrap.:: Washington, D.C. / December 2, 2025TRUMP: "...and we'll either let it expire or we'll maybe work out another deal with Mexico and Canada...":: FileThe agreement - known as CUSMA north of the border - exempts most Canadian goods from U.S. levies.While Mexico has started formal negotiations with the U.S. over the deal's renewal, Canada has so far only held informal talks.RAYMOND: "I think the CUSMA is very, very important because it trickles down to every little business right down to your barber shop and your nail shop, which will affect all of our customers."The situation in Windsor reflects a broader unease facing Canada's economy, which contracted 0.6% in the fourth quarter. About 90% of the city's exports cross the border, often multiple times during production.Manufacturing accounts for nearly a quarter of employment in the Windsor-Essex region.Its chamber of commerce, which represents about 750 businesses, says companies paused investments, delayed production, and cut jobs at the height of the tariff uncertainty last year. :: FileWindsor partly regained its footing as Trump exempted USMCA-compliant exports from Canada from tariffs in March last year.But uncertainty still drags on business confidence and Windsor's unemployment level remains one of the highest among major cities in Canada.Local shops complain of lower traffic and restaurants report thinner crowds.And builders say the housing market – often among the first sectors to show strain from the knock-on effects of tariff uncertainties – is near a standstill.Brent Klundert of BK Cornerstone, a local real estate builder, said he laid off 13 of his 21 staff as sales and prices slumped last year. "And you know, when people are going to make the biggest investment of their life, they really want confidence in their job, in the longevity of their job in the economy itself. And people lost that due to the tariffs.” // “If we can get through CUSMA, if we can get through our trade agreements with the US, I think that that will add a lot of confidence into the marketplace that we've been lacking.”Since January Klundert has rehired 10 of his employees, hoping homebuyers would start coming back.So far, only a few have.
The Science Behind How Submarines Stay Hidden
Submarines are the silent hunters of naval warfare, and that's thanks to their sonar deflecting shape and special propellers among other tricks.
Best Amazon Spring Sale gaming deals 2026: Mario Kart World at its lowest price ever
Editors' Choice Award-winning "Silent Hill f" is on sale.
Video: Super Mario Bros. Wonder Side-By-Side Graphics Comparison (Switch & Switch 2)
Spot the difference
Atlantic Trivia, March 27, 2026: Chinese Science
What ninth-century Chinese invention was at first employed primarily for fireworks rather than in the capacity that would change the world centuries later?
Rumor: Zelda: Ocarina of Time remake and new Star Fox game coming this year, no 3D Mario until 2027
Insider NateTheHate has provided an update on a variety of Nintendo projects, including rumors about Zelda remake, a new Star Fox game, and the lack of a 3D Mario in 2026. This comes from a new podcast published today. It’s claimed that Star Fox will be making a return on Nintendo Switch 2 this summer. Apparently it’ll be a classic...
NAVFAC Northwest Welcomes Marine Veteran and NAVFAC Expert as New Business Director
NAVFAC Northwest welcomed Tony King as its new Business Director this year.
A Grip on Sports: As we prep for a weekend full of college hoops and searching for the next M's game, we had to take a little time to look back at a disappointing Opening Day
A GRIP ON SPORTS • Why do the Mariners do this to us so often?
MLB Opening Day scores, live updates: Mariners face Guardians after Dodgers win, Paul Skenes falters vs. Mets
Video: Super Mario Bros. Wonder Nintendo Switch 2 vs. Switch graphics comparison
Super Mario Bros. Wonder Nintendo Switch 2 vs. Switch graphics comparison video is now available - see the improvement here.
Marina and bar owner remains hopeful after Key Bridge collapse impacted business
It was two years ago that the Key Bridge collapsed in seconds after being slammed into by the Dali cargo ship.It was one of those moments those in Maryland reme
Winning teams bring business boost to Seattle’s Pioneer Square
Seattle business owners near the city’s sports stadiums are expecting a significant economic boost as the Mariners season begins and the region prepares for the upcoming World Cup.
Winning teams bring business boost to Seattle’s Pioneer Square
Seattle business owners near the city’s sports stadiums are expecting a significant economic boost as the Mariners season begins and the region prepares for the upcoming World Cup.
UNCW to host free STEM expo focused on marine science
The UNCW STEM Expo will feature hands-on activities focused on North Carolina’s coast and marine environments.
World Cup 2026 stadium guides: Welcome to Los Angeles Stadium, the most expensive sports venue in the world
SoFi Stadium was primarily funded and developed by LA Rams owner Stan Kroenke. It will host eight games including two USMNT fixtures
Entertainment Listing: March 25
Wednesday March 25 Hangar 9 • Carbondale Open deck night, 9 p.m. PK’s • Carbondale Advertisement Trivia, 8 p.m. Project Human X • Carbondale Open studio, 4 p.m. Little Nashville • Marion Bingo, 6 p.m. Thursday March 26 Booby’s • Carbondale Karaoke, 8:30 p.m. Hangar 9 • Carbondale Jim Foerster and Jeff Bradley, 5 p.m....
Cable TV channels for Seattle Mariners games are set
Seattle Mariners games this season will continue to have a home on local cable, with specific channels now set for their broadcasts.
How to watch Mariners games: TV, streaming and channel info
Finally, just before opening day, an answer for fans looking to watch Mariners games on TV. Here's how to watch the M's through cable and satellite provider.
Woot is offering over 20 percent off Switch 2 controllers and games today
Mario Kart World is nearly $30 off right now.
Science happens here! Institute of Marine and Environmental Technology invites public to free Open House Saturday, May 2, 2026
Dive into the world of marine science and explore cool tech at this open house you won't want to miss! Have you ever wondered what happens in that unique
OpenAI shutters Sora: What’s next for artificial intelligence in entertainment?
Today on AirTalk: Open AI closes Sora; US at 250; Parenting in year 0; How is the Iran war affecting prices? Homelessness funds on the table; and Marine…
Essentia Health-Duluth Clinic welcomes Mariah O’Connell to practice family medicine
Mariah O’Connell, an advanced practice registered nurse and certified nurse practitioner specializing in family medicine, is thrilled to join the Essentia Health-Duluth Clinic.
Essentia Health-Duluth Clinic welcomes Marijah Harney-Tolo to practice dermatology
Marijah Harney-Tolo, an advanced practice registered nurse and certified nurse practitioner specializing in dermatology, is thrilled to join the Essentia Health-Duluth Clinic.
Shark scientists gather in Newport for the Northeast Pacific Shark Symposium
Shark scientists gathered at Oregon State University's Glady Valley Marine Science Building on the Hatfield campus in Newport to share research about shark species found on the west coast at the Northeast Pacific Shark Symposium.
Super Mario Bros. Wonder Has Been Updated To Version 1.2.0, Here Are The Full Patch Notes
Onward and upward!
Review: Super Mario Bros Wonder's 4K Upgrade For Switch 2 Shines
But the lack of a 120fps option feels like a missed opportunity.
Review: Super Mario Bros. Wonder - Nintendo Switch 2 Edition + Meetup In Bellabel Park - Inessential Bells & Whistles
Now with added Pikmin
Pulitzer winner 'Fairview' is a little cloudy in its L.A. premiere
Jackie Sibblies Drury's Pulitzer Prize-winning drama "Fairview" receives its L.A. premiere at the Matrix in a Rogue Machine production directed by Oz Scott.
Marion firefighters spend several hours at scene of overnight business fire
Fire breaks out at a business in Marion.
Super Mario Bros. Wonder + Meetup In Bellabel Park Review
Mario Wonder's Switch 2 upgrade adds neat single-player content, but the real draw is the massive array of multiplayer party games.
Ron DeSantis says Sean Hannity helped mend 2018 tiff between Donald Trump, top Florida Republicans over Hurricane Maria
It could have gone very differently had the conservative media icon not persuaded the President to drop a grudge.
Scientists Reflect on Experiences Meeting Patients
On the very best days, our researchers get to connect face to face with patients and families. Learn more about the meaning behind these moments.
Marathon has sold 1.2M copies across Steam, PS5, and Xbox
Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
DCCC reaches voters at the pump in 4 Florida congressional districts
The campaign will reach people in districts represented by Laurel Lee, Anna Paulina Luna, Cory Mills and Maria Elvira Salazar.
Pop-up bar dedicated to women's sports now open in Boston
261 at Para Maria is named for the bib number worn by the first woman to officially run the Boston Marathon.
2026 MLB Division Winner Odds: Dodgers, Mariners Favored to Repeat
The Dodgers and Mariners are expected to repeat as division champs. Every other division? Up for grabs. See the Opening Day odds.
Can Treating Peyronie’s Disease Improve Mental Health?
A University of Miami Miller School study explores how treatment for Peyronie’s disease may improve depression, anxiety and quality of life.
Service & Solidarity Spotlight: New Jersey Health Care Workers Vote to Join HPAE
New Jersey health care workers at Samaritan Healthcare & Hospice and Inspira Health have both voted to join the Health Professionals and Allied Employees (HPAE), an affiliate of the AFT.
H-1B Health Care Workforce Bill Introduced
On March 17, Congressman Mike Lawler (NY-17) introduced the H–1Bs for Physicians and the Healthcare Workforce Act , bipartisan legislation with Reps. Sanford D. Bishop, Jr. (GA-02), Maria Elvira Salazar (FL-27), and Yvette Clarke (NY-09). This legisla...
Entertainment and more in the Mid-Ohio Valley
PARKERSBURG – The Artsbridge calendar for this week: TODAY * Geppetto Woodcarver’s Wood Quilt display, 9 a.m. to 4 p.m., WesBanco, Market Street, Parkersburg * Art is Life/Life is Art, ages 55-plus,10:30 a.m. to 12:30 p.m., Parkersburg Art Center * Butterfly Photo Holder, ages 13-plus,11 a.m. to noon, Marietta Public Library * Hygge Club, adults, […]
Democratic and Republican Party officials face internal backlash after primaries
Party officials have received calls to resign amid endorsements and campaign spending in national and state primary elections.
Seattle Sports This Week: TV and radio for March 23-29
A look at the broadcast schedule for March 16-22 on Seattle Sports 710 AM and the Seattle Sports app, as well as local sports teams on TV.
Revolutionary Submarine Mysteriously Disappears Without a Trace – Scientists Are Now Preparing for a Bold Return
A pioneering robotic submarine that explored beneath Antarctica’s glaciers has been lost, but its discoveries are reshaping our understanding of ice melt as a more advanced successor is prepared to continue the mission.
How Will Gravity on Mars Affect Humans? A New Study Reveals a Clue.
Maintaining muscle mass is key.
Watch sperm whale headbutt another for no apparent reason
Researchers have captured extraordinary footage of sperm whales randomly headbutting each other, confirming anecdotal reports from mariners and whalers in the 18th and 19th centuries.
Trump to Maria Bartiromo: Iran wants to make a deal badly, could be within 5 days or sooner
Maria Bartiromo reports that President Donald Trump says Iran ‘wants to make a deal badly’ as he orders a five-day pause on planned strikes against key infrastructure, signaling ongoing high-level talks and triggering a sharp market rebound.
There’s little information about a large measles outbreak in Florida, so we went to see it
One of the largest measles outbreaks the US has seen in decades erupted at Ave Maria University in Florida, but very little information was being shared with the public. So CNN went to the small Florida town to learn what’s driving the case count.
Best selling author Marie Benedict to talk at the United Theatre
WESTERLY — Marie Benedict, the Pittsburgh-based author known for using real — mostly forgotten — women as inspiration for her bestselling works of historical fiction, was on the phone Tuesday
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Robert Mueller, former special counsel who led Trump-Russia probe, dies
A decorated Marine and longtime law enforcement leader, Mueller served as FBI director before taking on the high-profile investigation in 2017.
Farmers and rural community members can access free mental health resources
KGAN CBS 2 and KFXA Fox 28 provide local news, weather forecasts, notices of events and items of interest in the community, sports and entertainment programming for Cedar Rapids and nearby towns and communities in the Corridor and throughout eastern Iowa, including Iowa City, Waterloo, Dubuque, North Liberty, Coralville, Marion, Morengo, Williamsburg, Washington, Tiffin, Tipton, Solon, Mount Vernon, Lisbon, Central City, Urbana, Independence, Manchester, Dyersville, Oelwein, Cedar Falls, Waverly, Evansdale, Guttenberg, West Union, New Hampton, Decorah, Waukon, Maquoketa, Sigourney, Fairfield, Grundy Center, La Porte City, Dysart, Fayette, Elkader, Strawberry Point and Belle Plaine.
UFC London’s Felipe Franco promises entertainment after teammate Jailton Almeida’s release: ‘They want to see blood’
Felipe Franco battles undefeated Mario Pinto at UFC London
In Opening Day preview, Mariners thrash Guardians, 20-8
Mariners smoke six homers en route to big win; Cole Young goes yard twice and Dominic Canzone hits a grand slam
Brewers top Mariners in Spring Breakout matchup
Luis Peña homers, four others double in prospect showcase
Senate Democrats wade into their party's most contentious primaries: From the Politics Desk
Plus, more mixed messaging from the Trump administration on Iran.
The MacRumors Show: Surprise AirPods Max 2 Announcement
On this week's episode of The MacRumors Show, we discuss Apple's surprise announcement of the AirPods Max 2 this week. Subscribe to The MacRumors Show YouTube channel for more videos The AirPods Max 2 introduce a range of improvements primarily driven by the addition of Apple's H2 chip, which replaces the H1 chip used in previous models.
Pentagon orders 2,500 troops, 3 warships from California to the Middle East
The Pentagon deployed three warships and roughly 2,500 Marines to the Middle East from the California-based USS Boxer amphibious ready group and the 11th Marine Expeditionary Unit.
Nine Winters Bakery is closing in Cambridge: 'I'm choosing my family'
In an Instagram post, owner Marissa Ferola addressed the closure and said the last day of service is at the end of the month.
Simply Secunda Baking founder discusses sweet potato pie business, $10K startup
Simply Secunda Baking founder Secunda Anderson shares how she launched her sweet potato pie business during COVID-19 with a $10,000 investment on ‘Mornings With Maria.’
Cal, Randy team up in Seattle Mariners' 6-run inning
Cal Raleigh and Randy Arozarena are officially Seattle Mariners teammates again, and if you need proof, just look at Thursday's box score.
2 measles exposure sites identified at Salem health centers, Oregon officials say
PORTLAND, Ore. (KOIN) — Two Salem health centers were identified as the latest measles exposure sites in Oregon, officials said. The Oregon Health Authority and Marion County public health official…
Mid-Ohio Valley Entertainment Commission hosts training session on film production
The Mid-Ohio Valley Entertainment Commission brought together film enthusiasts for a film crew training event at Marietta College on Sunday. The event sought to promote creativity and inspire filmmakers in the region. The event was originally scheduled for the entirety of the weekend but due to weather, the session was condensed to Sunday only. MOV […]
Mid-Ohio Valley Entertainment Commission hosts training session on film production
MARIETTA – The Mid-Ohio Valley Entertainment Commission brought together film enthusiasts for a film crew training event at Marietta College on Sunday. The event sought to promote creativity and inspire filmmakers in the region. The event was originally scheduled for the entirety of the weekend but due to weather, the session was condensed to Sunday […]
Preview: Seattle Mariners picked to win AL West again
After winning their first AL West title since 2001, the Seattle Mariners are looking to do it again with Cal Raleigh, Julio Rodríguez and a strong rotation.
'Dark oxygen' discovery on the seafloor is 'fundamentally at odds with thermodynamics' and should be retracted, experts say
In a recent opinion article, marine scientists and electrochemists listed a number of reasons why it's unlikely that metallic nodules on the deep seafloor could produce oxygen in total darkness.
Treasury Secretary Bessent unveils plan to flood market with oil amid Iran war
Treasury Secretary Scott Bessent joins ‘Mornings with Maria’ to discuss the Iran war, surging oil prices, market volatility, Fed uncertainty, Powell’s future and the U.S. strategy to stabilize the global economy.
Nintendo brings hands-on Nintendo Switch 2 gameplay experiences featuring Mario and Pokémon to PAX East 2026 - News
From March 26 to 29, Nintendo is bringing some of the latest Nintendo Switch 2 game experiences to Boston’s Thomas M. Menino Convention & Exhibition Center. Celebrate the launch of the Super Mario Bros. Wonder – Nintendo Switch 2 Edition + Meetup in…
National survey of NIH-funded researchers shows precarious state of U.S. science — ‘This is like the Titanic’
A nationwide STAT survey of NIH-funded researchers reveals that, a year after Donald Trump's return to the White House, many scientists are reeling
Google Shakes Up Its Browser Agent Team Amid OpenClaw Craze
As Silicon Valley obsesses over a new wave of AI coding agents, Google and other AI labs are shifting their bets.
Arizona health officials recall marijuana preroll over possible fungal contamination
Arizona health officials are recalling a specific marijuana product due to possible fungal contamination.
Grand Central Mall announces multi-million dollar renovation plans, entertainment center
VIENNA — A multi-million-dollar renovation project is set to transform Grand Central Mall, with officials and community leaders announcing sweeping upgrades and new attractions during a Wednesday morning event. Joe Bell, director of corporate communications, said the planned changes will significantly modernize the longtime shopping center and bring new energy to the Mid-Ohio Valley. “There […]
Marijuana businesses urge CCC to consider freezing new licenses
The proposed move is aimed at curbing plant oversupply and stopping price plummet.
Maine gubernatorial candidates outline health care visions
The Democratic and Republican primaries are set for June 9 and the general election is set for November 3.
'The Adding Machine' review: Elmer Rice's play gets a sluggish revival
Elmer Rice's "The Adding Machine," an expressionist classic on automation and worker insecurity, speaks directly to an age in which livelihoods are threatened by AI innovation.
Israel is a key issue in Democratic primaries as support for the U.S. ally drops
Support for Israel is down among Americans, particularly Democrats, with the last couple years being a major turning point.
11Alive
WXIA (Atlanta) — 11Alive is your source for breaking news, Georgia weather, traffic, and live coverage in Atlanta and across the metro area. Get the latest updates from the 11Alive team — from major local headlines and investigations to severe weather, community stories, and the moments everyone’s talking about. Watch live newscasts, stream breaking coverage, and catch up on the top stories shaping Atlanta, Marietta, Sandy Springs, Decatur, and surrounding communities. Subscribe for: • Atlanta breaking news + live updates • Georgia weather forecasts, storms, and severe weather alerts • Investigations and accountability reporting • Community stories across the metro area • Major events, sports, and local explainers WXIA / 11Alive — Atlanta news and weather, live and on demand. 🔗 More: https://www.11alive.com
As polls head toward closing time, precincts report low turnout
A roundup of the results in key Chicago-area congressional primaries.
Live Results: Illinois midterm primary elections
Illinois voters are deciding primaries Tuesday for six open U.S. House and Senate seats that will spur a new generation of leadership in the state’s heavily Democratic congressional delegation.
Illinois primary elections
See Illinois election results and maps for the 2026 primaries.
Scientists say marijuana doesn’t ease anxiety or other mental health conditions
Using medical or recreational marijuana to ease symptoms of numerous mental health conditions doesn’t work, according to new analyses
Scientists say marijuana doesn't ease anxiety or other mental health conditions
Using medical or recreational marijuana to ease symptoms of numerous mental health conditions doesn't work, according to two new analyses of existing gold-standard research.
Outside Lands act to play intimate Bay Area shows ahead of festival
Mariah the Scientist will be in San Francisco and Oakland for her “Hearts Sold Separately” tour, in support of her recent album of the same name.
Fields now set for Maine June primaries
Gov. Janet Mills, combat veteran and oyster farmer Graham Platner and David Costello, a former senior level government official, are all competing for the right to face Sen. Susan Collins in the fall.
What to watch for at Illinois primary elections: JB Pritzker's opponent, Dick Durbin's replacement
A hard-fought Senate race, several raucous open House primaries and Gov. JB Pritzker's bid to extend his control over Illinois politics are all at stake Tuesday.
Mark your calendars: Weekly sports schedule for March 17-22
Take a look through the weekly sports schedule for the Central Coast, and make your plans to get out and attend, to support local sports programs. Read our coverage online
Alabama's Aden Holloway arrested after authorities allegedly found over a pound of marijuana at residence, expected to miss NCAA tournament
Using marijuana to ease anxiety or depression? Science shows the evidence isn’t there
Marijuana doesn’t help with anxiety, PTSD, depression or other mental health conditions, according to two large, new studies.
Survey: Most Massachusetts residents unaware of cannabis mental health risks
A state survey of more than 11,000 Massachusetts residents found widespread misunderstanding about the mental health risks tied to regular marijuana use, including links to psychosis and schizophrenia.
Amid blackouts in Cuba, Mario Díaz-Balart sees communism's future fading on the island
Florida's Cuban American GOP delegation says the 'countdown to a free Cuba' has begun.
MLB Free Agency Outlook: Arozarena, Skubal among top names
Two-time Cy Young winner Tarik Skubal and Seattle Mariners OF Randy Arozarena could become free agents for the first time after the World Series next fall.
State Announces Intent to Award $20 Million to Santa Barbara County for New Behavioral Health Residential Facilities in Santa Maria
Funding Through California’s Behavioral Health Continuum Infrastructure Program Will Support Two 16-bed Community Residential Treatment Facilities Focused on Diversion and Recovery
Young Patriots LB Fueling Passion For Entertainment
Just a few weeks after Amari Gainer made a trip to the Super Bowl, the New England Patriots linebacker decided to take another trip to California. This time, in
Poll: Israel's standing plummets among Democrats, fueling primaries on the left
More registered voters view Israel negatively than positively in the latest NBC News poll, driven by change among independents and especially Democrats.
Extreme Ocean Pressure Is Feeding Deep-Sea Life in a Way Scientists Never Expected
High pressure in the deep ocean may squeeze nutrients from sinking “marine snow,” feeding deep-sea microbes and altering how carbon moves through the ocean.
Texas Could See A Spike In Raids On Hemp Businesses Under New Rules, Industry Advocates Fear
“People don’t know what the rules are. They don’t know what is in effect at a certain time… There is overall confusion around regulations, and that is the biggest issue.” By Stephen Simpson, The Texas Tribune Dallas attorney Chelsie Spencer specializes in making sure Texas businesses that sell hemp-derived THC products know how to stay […]