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Feds probe 'missing scientists' list. Who has died, disappeared?
The cases span multiple years and include a patchwork of people from different backgrounds, circumstances and connections to classified material.
Leaked One UI 8.5 changelog details new features on Galaxy S25, AirDrop and more
The One UI 8.5 changelog for the Galaxy S25 series appeared online, signaling what could be a rollout in the...
'The Neighbourhood': Graham Norton Praised By Team Behind ITV Show
Graham Norton has been praised for his hosting of 'The Neighbourhood, ITV's Saturday night show, after he appeared in a Taylor Swift video.
Francisco Lindor exits tonight’s game with left calf tightness
Lindor appeared to be in pain as he scored on an Alvarez double.
Adversaries may have taken missing US scientists, lawmaker says
Nearly a dozen scientists have disappeared or died in circumstances that some observers have deemed suspicious.
Robert F. Kennedy Jr. Defends Spending Cuts to Health Agencies
Kennedy appeared before a Senate Appropriations subcommittee about the President’s 2027 budget.
Ancient DNA reveals a hidden Neanderthal group frozen in time
A remarkable genetic breakthrough has uncovered what may be one of the clearest snapshots yet of a Neanderthal “community” living together 100,000 years ago in what is now Poland. The findings reveal that these individuals shared genetic ties with Neanderthals spread across Europe and the Caucasus, hinting at widespread ancient lineages that later disappeared.
Adversaries may have taken missing US scientists, lawmaker says
Nearly a dozen researchers or people with links to aerospace or defense programs have disappeared or died in circumstances that some observers have deemed suspicious.
At least 10 scientists tied to sensitive US research have died or disappeared in recent years, sparking federal investigation
At least 10 people tied to sensitive US nuclear and aerospace research have died or disappeared in recent years, prompting federal investigations into whether the cases are connected.
Inside the debate that sank a small business health insurance bill
With the state legislature focused this session on affordability, a proposal that aimed to lower health insurance costs for small and midsize businesses appeared to have momentum — including backing from Gov. Ned Lamont. But the bill stalled in the Appropriations Committee.
College athlete gave up athletic scholarship; was it the right choice
Growing up, running was my life, and I worked hard to earn a college scholarship. But when I started school, my passion for the sport disappeared.
Shaky political science: using "simulated" elections over real-world elections
[Dear DSOS readers – this article is the latest in our “Shaky Political Science” series. In our 38 page report, “Shaky political ‘science’ misses mark on ranked choice voting,” released in early December, we examined over 40 studies focused on ranked choice voting. We found that many of these studies suffered from puzzling research methodologies, poorly constructed surveys, unrealistic simulated elections, cherry picked data, and faulty analyses that often were contradicted by results from real-world elections (a link to our full paper is here). Here are links to the first three articles in our series: the first one summarizing the overall results of our report, the second one analyzing a study co-authored by University of Minnesota academic Larry Jacobs, which was one of the most error-prone of all the research we reviewed in our report, and a third article showing an admirable example of two political scientists holding two other political scientists accountable for their flawed, sloppy research]. In this fourth article in our “Shaky Political Science” series, we shine a spotlight on seven studies that were web-hosted and funded by New America’s Political Reform Program and its Electoral Reform Research Group (the ERRG is an ad hoc committee headed by New America’s Political Reform Program and joined by the American Enterprise Institute, the Unite America Institute and Stanford University’s Center on Democracy, Development, and the Rule of Law). This research consortium has been led by Lee Drutman, senior fellow with New America’s Political Reform Program. These seven studies are simply not credible from any objective standard about how political “science” is supposed to illuminate our understanding of either ranked choice voting or politics in general. The feature that six of these seven studies have in common is that they all used surveys – artificial, simulated elections -- to attempt to say something cogent or interesting about ranked choice voting (RCV) elections. None of them used real world data from actual RCV elections – either the 1000+ elections in the US or the many thousands of elections from places like Australia, Ireland and elsewhere where RCV has been used for 100 years. While a few of these studies conclude with some mixed positives about RCV, our analysis here is content neutral. The idea that, with a political reform like RCV, you can ask respondents in a mock, artificial election to vote with that method, with only the barest of explanation about how RCV works or its likely impacts (i.e. no spoiler candidates, majority winners, voters liberated to pick their favorite candidates, coalition-building), and then ask them their thoughts/reactions about voting in that system, with fake candidates and no real campaigning, no real exposure to an actual election or actual candidates, rests on some very puzzling assumptions. The findings of these seven studies actually are contradicted by the findings from many other studies based on real-world RCV elections. These New America studies also failed to list the real-world RCV studies in their own citations, instead including those studies that reinforced their conclusions. The seven studies featured in this article were chosen because they form a cohesive cohort which precisely illustrates one of the main points of our research paper, namely that using surveys, i.e. artificial elections, or mathematical/theoretical models, instead of real-world data, is in fact “shaky political science.” Below are summaries of our analysis of five of the seven New America studies. You can read our complete analysis of all seven studies at our paper, “Shaky political ‘science’ misses mark on ranked choice voting.” Choosing to “Vote As Usual” by Andre Blais, Carolina Plescia, and Semra Sevi. New America. (Blais et al., 2021). This study, web-hosted and funded by New America’s Political Reform Program and its Electoral Reform Research Group, used two surveys in which respondents completed ballots for simulated elections using plurality, approval, RCV and point (Score) voting. In both cases the authors provided the respondents with only minimal explanation of each method. For example, the entire explanation for RCV was “For this vote, rank the candidates from your first to your last choice (you do not need to rank them all). This is called the ranked vote.” That’s it. The study did not provide any context or explanation to survey respondents about why she/he might want to rank multiple candidates. Participants were not even told that ballots would be tabulated using an “instant” runoff, not to mention any description of RCVs ability to eliminate the spoiler effect or liberate voters to rank their favorite candidates without fear of helping the “greater evil” candidate to win. That’s like taking an iPhone back in time to 1970 and asking someone if they like it better than their rotary phone without explaining how it works. Their first survey targeted states that held 2020 Super Tuesday Democratic primaries and used the real candidates’ names in the survey; the second survey used fictitious candidates. In other words, they surveyed respondents who had only ever participated in plurality elections, had no history or background with using RCV or any of the other methods, had no clue about its likely impacts, and did not communicate how the alternative methods would be counted, and then asked them: “How satisfied are you with using each system?” Predictably, the winner was plurality elections, the system used for president, Congress, gubernatorial and state legislative elections – in other words, the method they have been using, year after year, all their voting lives. With so little explanation of RCV and its impacts, this study is simply not credible in discovering anything useful about real-world RCV elections. It merely shows that a basic voter education campaign is needed when adopting a new election system. Additionally, the result contradicts many other post-election surveys following real RCV elections, asking opinions from voters who had just participated in a RCV election, that showed a great deal of satisfaction with RCV (see details on that in Studies 22-25 in our paper, as well as the four studies cited in the review for Study 28). Share Other studies on “satisfaction” and “understanding” make similar mistakes, in terms of basing their surveys on inadequate explanation to respondents and lack of education about context. How could any survey ever hope to measure accurately, in essence simulate a real-world election, without actual campaigning candidates, the media writing about those candidates, organizations endorsing candidates and voters being inundated with crucial information? More than anything, what these “studies” based on surveys show is that if you ask voters about something they don’t know very much about, and fail to adequately educate them, their responses will unsurprisingly reflect their confusion. Equally puzzling is that New America’s Electoral Reform Research Group, headed by political scientist Lee Drutman, found this to be a credible enough study that they not only published it but highlighted it in Drutman’s own discussion of research related to ranked choice voting. This pattern was repeated in study after study featured by New America’s Electoral Reform Research Group. For example in Ranked-Choice Voting and Political Expression: Voter Guides Narrow the Gap between Informed and Uninformed Citizens by Cheryl Boudreau, Jonathan Colner, and Scott MacKenzie, the researchers based their analysis on a survey which found that respondents who were asked to vote in a simulated RCV election, with minimal explanation of RCV or how it works, displayed less evidence of being informed about how to use RCV effectively, with the least informed voters ranking fewer candidates. As pointed out under the study above, in a real election voters are informed by a wide variety of methods, including public education by the election administration, by interested political groups, the media, and the candidates themselves who benefit from voters being aware of how to vote in the new system. In Support for Ranked-Choice Voting across Race and Partisanship by Joseph Anthony, David C. Kimball, Jack Santucci and Jamil Scott, the researchers used respondents from different parties and races voting in simulated plurality and RCV elections, who indicated their satisfaction with each voting method. Instead of using real world election results, the authors fell back on the easy, armchair and less reliable academic research methodology of making up mock elections. As with the other studies, little explanation was given of how RCV works or what its implications might be (electing majority winners or eliminating spoilers, for example). Unsurprisingly, this study found that respondents were not very satisfied with RCV. However, when the authors added an explanation that RCV has a tendency to elect more women and people of color, they found that this greater explanation increased the preference for RCV. The more voters were familiar with it, and the more they understood potential positive impacts – surprise! -- the more they were open to switching away from the status quo. Of note, the results from this study are thoroughly contradicted by a number of other studies whose data was obtained from real RCV elections with real voters. Those studies show a great deal of satisfaction with RCV. More “fake election” research An interesting wrinkle on this “research by fake elections” approach, which only served to illustrate how unreliable such “research” can become, was taken in Ranked-Choice Voting, Runoff, and Democracy: Insights from Maine and Other U.S. States by Joseph Cerrone and Cynthia McClintock_,_ also web-hosted and funded by New America’s ERRG. It gets high marks for creativity, but an eye-roll for thinking this could possibly add anything meaningful to our understanding of real world RCV elections. This study tried to determine whether RCV, plurality or two-round runoff elections provided greater voter satisfaction and acceptance of election results. To determine that, the authors conducted a survey asking if voters were satisfied with a fictional newspaper report of an election, with three different versions given to respondents – plurality, runoff and RCV, with variations of Republican/Democrat winners and variations of “come-from-behind” winners,” i.e. candidates not initially in first place but who win the “runoff.” Again, a minimal explanation of RCV or how it works was given, and the survey showed that respondents had the greatest unfamiliarity with RCV than the other methods. The unsurprising result? Respondents were much more satisfied with “come-from-behind” victories in a traditional two-round runoff election than in RCV, even though RCV is also a runoff system but with a single round of counting. Interestingly, the dissatisfaction with RCV disappeared for those who were more familiar with RCV. In fact, among those respondents who were “very familiar” with RCV, they were equally satisfied with RCV, runoff and plurality. Surprise, surprise. Again, what this study revealed, more than anything, is not only the inadequacy of the explanation for RCV given by the authors of this study, but the failure of the research format itself, thinking that such an artificial mock election could somehow simulate what actually happens in the real world in a real RCV election. Those four studies reviewed above are fitting examples of inadequate and shaky political “science.” Other studies reviewed in our paper from the New America/Electoral Reform Research Group cohort which also used mock elections included: Ranked-Choice Voting is an Acquired Taste by Joseph Anthony and David C. Kimball. New America. (Anthony et al., 2021). Ranked-Choice Voting is No Refuge for Extreme Candidates by Melissa Baker. New America. (Baker, 2021). Also included in this New America cohort is Does Ranked-Choice Voting Reduce Racial Polarization? by Yuki Atsusaka and Theodore Landsman, which actually did use real-world election results data but applied an odd and unconventional methodology to the data which relied on shaky assumptions and non-real-world scenarios that were too divorced from reality. To determine levels of “racially polarized voting,” the researchers imagined “ethnic parties,” by which they mean political parties for each ethnic group, which was especially odd since the election data they were using came from nonpartisan RCV races. But then they made an even odder assumption, namely that since race and ethnic characteristics of studied voters were not available, the authors tried to infer that information based on who voters selected and the racial make-up of voters in each district. This amounted to little more than vague and ambiguous guesswork dressed up with a bunch of mathematical equations used to give it a veneer of scientific appearance. Indeed, it seemed to assume racial polarization in order to prove racial polarization. Based on this questionable methodology, the authors concluded that RCV doesn’t reduce racial polarization. But the premise of this study missed an obvious reality: since RCV incentivizes more candidates to run and can result in more diverse fields of candidates, one would expect more racially-polarized voting in voters’ top rankings, not less, because more voters would have someone on that ballot who represents their racial or ethnic identity and more freedom to vote for their real first choice. By encouraging more diverse candidates and eliminating the spoiler effect, RCV facilitates voting for a favorite candidate of your own race and then selecting a second choice with the best likelihood of winning. The real measure is what voters do with their additional rankings – do they consider other candidates and vote “for the best of the rest”? This study didn’t tell us anything useful about that. But readily available data shows this is common in real RCV elections, and candidates act on this knowledge by engaging with voters outside their racial group. So the authors of this study failed to consider or account for what actually happens in real-world elections, and their conclusions are tainted by this failure. New America has contributed a great deal over the past 2.5 decades to our understanding of many policy areas, including politics and political reform (full disclosure: Steven Hill, one of the authors of this article and of the “Shaky Political Science” research paper and series, is a former senior fellow and former director of New America’s political reform program, 2005-2010). So it was especially disappointing that New America funded and published such a large batch of dubious studies about ranked choice voting. The stated praiseworthy goal of its Electoral Reform Research Group was to inspire new academic research about ranked choice voting that would shed light and help the public better understand the impacts of RCV. Instead, the ERRG research did just the opposite. It produced dubious research that created more confusion and misinformation. In so doing, New America’s political reform program contributed to “shaky political science.” Steven Hill and Paul Haughey Share Upgrade to $5 subscription Thanks for reading DemocracySOS, a reader-supported digital portal for the pro-democracy movement. Subscribe for only $5 per month to receive full benefits and to support our work. Subscribe
Scientists just captured trees glowing with electricity during storms
Scientists chasing thunderstorms in a retrofitted minivan finally captured something never seen before in nature: faint electrical glows shimmering from treetops during a storm. These “corona discharges,” long suspected but never observed outside a lab, appeared as tiny UV flashes at the tips of leaves. The discovery could reshape how we understand forests, since these bursts may help clean the air by breaking down pollutants.
A deal to end the Iran war seemed close. Then Trump started posting on social media
As the weekend approached, the US and Iran appeared to be closing in on a deal to end the seven-week war.
Charlie Kaufman Talks Béla Tarr & Dissects His Own Creative Process
Charlie Kaufman appeared at the Sands Film Festival alonside his longtime collaborator Eva H. D.
Charlie Kaufman On Finding Inspiration In Béla Tarr & Why He Isn’t Interested In “Conventional Notions Of Entertainment”
On Saturday evening, the veteran American filmmaker Charlie Kaufman appeared at the Sands Film Festival in St Andrews, Scotland, for an onstage Q&A, originally billed as an exploration of the relation...
Bruins Collapse in Third Period, Drop Game 1 to Sabres
BUFFALO, NY – The atmosphere inside the KeyBank Center was second to none, and it only grew louder in the […] The post Bruins Collapse in Third Period, Drop Game 1 to Sabres appeared first on Boston Hockey Now.
AI swarms could hijack democracy without anyone noticing
AI-powered personas are becoming so realistic that they can infiltrate online communities and subtly steer public opinion. Unlike traditional bots, they adapt, coordinate, and refine their messaging at a massive scale, creating a false sense of consensus. Early warning signs—like deepfakes and fake news networks—have already appeared in global elections. Researchers warn that the next election could be the true test of this technology’s power.
The Strokes end Coachella weekend two set with politically charged video targeting CIA and US government
The Strokes appeared to take aim at the U.S. government during Coachella, closing their set with a video referencing the CIA, Gaza and Iran bombings.
Announced, Delayed, Disappeared: The Games Still In Limbo
These games were announced years ago, but where are they now?
Former U.S. Presidents, Entertainment, Sports and Media Leaders Convene in Rare Gathering to Celebrate Country’s 250th Anniversary
Former president Barack Obama appeared alongside former first lady Michelle Obama, five other former U.S. leaders, actors Nicole Kidman and Ted Danson, 'SNL' players Tina Fey and Colin Jost, NFL playe...
Obama, Nicole Kidman, Tina Fey, Jason Kelce Attend HISTORYTalks 2026
Former president Barack Obama appeared alongside former first lady Michelle Obama, five other former U.S. leaders, actors Nicole Kidman and Ted Danson, 'SNL' players Tina Fey and Colin Jost, NFL players Tom Brady and Jason Kelce, and more to discuss legacy and leadership for HISTORYTalks 2026.
New Jersey Devils Hit Home Run With Sunny Mehta Hire
The New Jersey Devils have entered the “Mehtaverse” after hiring Sunny Mehta as the team’s new general manager. The former Florida Panthers assistant GM now gets his first crack as the head man in charge. It’s also a homecoming for Mehta, who grew up in Wycoff, NJ, and was the team’s head of analytics […] The post New Jersey Devils Hit Home Run With Sunny Mehta Hire appeared first on The Lead.
Jack Schlossberg May in Fact Happen, According to Polls
A new poll showed the Kennedy scion leading the field in the NY-12 race, but a significant number of voters still appeared undecided.
'My fire is there' - Howe comes out fighting
This was the day when Eddie Howe channelled his inner Mikel Arteta. "My fire is there," the Newcastle United head coach said as he echoed words from his Arsenal counterpart. Having appeared a little flat at his news conference a week previously – even before a subsequent defeat against Crystal Palace - a defiant Howe came out fighting on Friday.
10 Takeaways: Avalanche Break Franchise Record In Regular Season Finale
The 2025-26 Avalanche are officially the best regular-season team in franchise history. After defeating the Seattle Kraken 2-0 on Thursday, […] The post 10 Takeaways: Avalanche Break Franchise Record In Regular Season Finale appeared first on Colorado Hockey Now.
Kennedy announces policy changes and faces criticism at House hearings
The health secretary appeared before two House committees to discuss proposed funding cuts. Several lawmakers pressed Kennedy about his response to measles outbreaks.
Can the Cavs Set Their Playoff Tone Against the Raptors?
The 2026 NBA playoffs have taken shape, and the Cleveland Cavaliers look to right the wrongs of years past. This year, the wine and gold will face an old playoff foe in the Toronto Raptors, a team the franchise has familiarity with from its days with LeBron James leading the charge. However, this is a […] The post Can the Cavs Set Their Playoff Tone Against the Raptors? appeared first on The Lead.
Lakers’ Luka Doncic Will be Eligible for Awards After All
Lakers superstar Luka Doncic will be eligible for awards like MVP and All-NBA despite not meeting the minimum games played threshold. Doncic and Cade Cunningham of the Detroit Pistons were both granted their extraordinary circumstances challenges, as reported by ESPN’s Shams Charania. Doncic’s exemption was related to the birth of his daughter in Slovenia in […] The post Lakers’ Luka Doncic Will be Eligible for Awards After All appeared first on LA Sports Report.
White House looking into growing list of ‘missing scientists’
Theories have circulated online after about ten scientists disappeared or died since 2024
Angels’ Jorge Soler Gets Decision on Suspension Appeal After Brawl
MLB adjusted Los Angeles Angels slugger Jorge Soler's punishment following his appeal after he received a seven-game suspension. The post Angels’ Jorge Soler Gets Decision on Suspension Appeal After Brawl appeared first on LA Sports Report.
Red Wings at Panthers: Notes, Lines, Goalies, How to Watch
The post Red Wings at Panthers: Notes, Lines, Goalies, How to Watch appeared first on Detroit Hockey Now. The Detroit Red Wings (41-30-10) are on the road today to play the Florida Panthers (39-38-4). The Red Wings have […] The post Red Wings at Panthers: Notes, Lines, Goalies, How to Watch appeared first on Detroit Hockey Now.
100 Points: Breaking Apart Bruins’ Win Over Devils
BOSTON – The Boston Bruins reached 100 points on Tuesday, and so did David Pastrnak, just in a different way. […] The post 100 Points: Breaking Apart Bruins’ Win Over Devils appeared first on Boston Hockey Now.
NFL Reporter Dianna Russini Resigns Amid Mike Vrabel Photos
Dianna Russini has resigned from The Athletic following a wave of controversy tied to photos of her with Mike Vrabel. The NFL Reporter Dianna Russini Resigns Amid Mike Vrabel Photos first appeared on The Blast
JD Vance Heckled In Antiwar Protest at Turning Point USA Event
Vice President JD Vance appeared to express sympathy with critics of the war with Iran: “I recognize that young voters do not love the policy we have in the Middle East, OK. I understand.”
Steelers LB Patrick Queen Reveals Odds on Aaron Rodgers’ Return
Like everyone, Pittsburgh Steelers linebacker Patrick Queen is just waiting to hear if four-time NFL MVP quarterback Aaron Rodgers will […] This article originally appeared on Steelers Now: Steelers LB Patrick Queen Reveals Odds on Aaron Rodgers’ Return
Disney quietly delists 15 more games on Steam, including a couple of classic Star Wars titles
After 14 removals earlier this year, another 15 Disney-owned games have suddenly disappeared from the Steam store.
Flyers are Playoff Bound After Shootout Win vs. Hurricanes
PHILADELPHIA – Both teams picked up a point on Monday as the Philadelphia Flyers (42-26-12) beat the Carolina Hurricanes (52-22-7) […] The post Flyers are Playoff Bound After Shootout Win vs. Hurricanes appeared first on Philly Hockey Now.
After Criticizing Pope, Trump Posts Image of Himself as a Jesus-Like Figure
The image, posted on Truth Social, appeared to be A.I.-generated and depicts the president as a divine leader healing the sick.
Red Wings Recall Brandsegg-Nygard For Season-Ending Road Trip
The post Red Wings Recall Brandsegg-Nygard For Season-Ending Road Trip appeared first on Detroit Hockey Now. In what can only be described as a puzzling decision, now that it’s too late to help, the Detroit Red […] The post Red Wings Recall Brandsegg-Nygard For Season-Ending Road Trip appeared first on Detroit Hockey Now.
'Human minds shouldn't have to go through' this: Artemis II crew recalls unreal moment when Earth disappeared — Space photo of the week
A stunning Earthset image from Artemis II recalls Apollo 8's Earthrise, marking humanity's return to deep space and the start of a new era of exploration.
Flyers Postgame Blog: Statement Win; Vladar Bounces Back; Vintage Couturier
The Philadelphia Flyers made a statement on Saturday. It was a dominating 7-1 win over the Winnipeg Jets that lowered […] The post Flyers Postgame Blog: Statement Win; Vladar Bounces Back; Vintage Couturier appeared first on Philly Hockey Now.
See 16 Actors You Forgot Guest Starred on 'Twin Peaks'
'Twin Peaks' premiered on ABC on April 8, 1990. From David Duchovny to Amanda Seyfried, find out the actors who appeared on the genre-bending TV series before (or even after!) they were famous.
5 To Watch: The Masters Edition & The Business of the Tournament
Check Out the 5 to Watch Masters Edition Below: This week with “The Sports Professor” Rick Horrow features a special edition with five things to watch at The Masters at Augusta National. Mr. Horrow goes behind the tournament with Amazon.com, Inc. (Nasdaq: AMZN) Video providing two hours of exclusive live coverage before handing it over […] The post 5 To Watch: The Masters Edition & The Business of the Tournament appeared first on CorpGov.
Oppo Find X9 Ultra full specifications, images emerge via premature listing
The Oppo Find X9 Ultra is expected to go official on April 21 across multiple markets, including China. Ahead of the launch, the device briefly appeared on China Telecom’s database. While the listing has now been removed, it revealed several key specifications and design details, as seen in screenshots circulating online. Oppo Find X9 Ultra […]
NVIDIA N1 Gaming SoC Surfaces on Laptop Motherboard with 128 GB LPDDR5X Memory
NVIDIA's upcoming N1 SoC, designed for gaming laptops, has officially appeared for the first time alongside its motherboard intended for a laptop. Featuring 128 GB of LPDDR5X memory running at 8,533 MT/s, the SoC is paired with SK hynix modules. NVIDIA's OEM partners for this launch, including Dell ...
Another NHL Debut? Florida Panthers Call Up Rookie Defenseman
The Florida Panthers have had quite a few of their youngsters get their first taste of the NHL and, tonight […] This article: Another NHL Debut? Florida Panthers Call Up Rookie Defenseman originally appeared on Florida Hockey Now.
Bartholomew’s heroics save Cyclones in rivalry game
IOWA CITY — While the rain appeared heavy at times on the Big Ten Network stream it was a case of “when it rains, it pours” as Iowa State (23-15, 4-8 Big 12) and Iowa (21-17, 5-10 Big Ten) combined for five home runs, punctuated by Reagan Bartholomew’s game-winning two-run homer to deep center field […]
Could the 2026 Pittsburgh Penguins Recapture the Magic of 2016?
It’s now been a decade since the Pittsburgh Penguins hoisted their fourth Stanley Cup, and ten years later, the team is looking to recapture that magic once more. Only four members remain from the 2015-16 team: Sidney Crosby, Evgeni Malkin, Kris Letang, and Bryan Rust. Four guys who not only know what it’s like to […] The post Could the 2026 Pittsburgh Penguins Recapture the Magic of 2016? appeared first on The Lead.
Losing Dexter Lawrence Would Make the Giants’ Defense Collapse
After years of contract issues, New York Giants superstar defensive tackle Dexter Lawrence II has requested a trade. Lawrence’s disgruntledness doesn’t come as a surprise. Despite his All-Pro production, he ranks just 12th among NFL interior defensive linemen in terms of salary. So, with Lawrence’s established, elite production at 28 years old, the Giants shouldn’t hesitate […] The post Losing Dexter Lawrence Would Make the Giants’ Defense Collapse appeared first on The Lead.
World Health Day: Why This Work Continues
Subscribe on LinkedIn This story first appeared in Amy Weaver’s LinkedIn newsletter, Direct Relief: Hope Ahead. World Health Day offers a moment to pause and reflect—and this one feels especi…
Sony Interactive Entertainment announces The Playerbase program to scan players into PlayStation games
Sony Interactive Entertainment has announced “The Playerbase,” an opportunity for PlayStation fans to have their likeness scanned and appeared within a PlayStation game, starting with G…
Victor Wembanyama leaves Spurs-76ers early with left rib contusion
The MVP candidate appeared to be favoring his left side after a collision with Paul George during the second quarter.
Iran rejects latest ceasefire proposal as Trump’s deadline approaches
TEHRAN, Iran (AP) — Iran on Monday rejected a 45-day ceasefire proposal and said it wants a permanent end to the war, while President Donald Trump appeared to widen his threat from civilian targets to the whole Islamic Republic and his ultimatum ticked closer. “The entire country can be taken out in one night, and […]
Trump threatens Iran with ‘Hell’ as pope prays for peace
Trump’s message featured obscenities and appeared to mock Islam
Scientists found a “lost world” of animals that shouldn’t exist yet
A remarkable fossil discovery in southwest China is rewriting the story of how complex animal life began, showing that many key animal groups appeared millions of years earlier than scientists once believed. Dating back over 540 million years, the fossils reveal a surprisingly diverse and advanced ecosystem from the late Ediacaran period—before the famous Cambrian explosion. Among the finds are early relatives of starfish, worm-like creatures, and even ancestors of animals with backbones, suggesting that the roots of modern life were already taking shape.
Guttermouth Announce (Another) “Final” Australian Tour
"Grab a ticket if you’re game for one more round. Or don’t. Mark’s feet are up, cold one in hand, zero fucks left." The post Guttermouth Announce (Another) “Final” Australian Tour appeared first on Mu...
Nampa City Council greenlights alcohol sales at two businesses
This story originally appeared in the Idaho Press. At its March 30 meeting, Nampa City Council approved sales for each business, though the types of alcohol each can serve differs based on city rules...
What Happened To Zenith TVs? Why The American Brand Disappeared
At its height, Zenith was a premier American TV manufacturer well known for top-of-the-line sets. So, what went wrong that caused the brand to disappear?
I watched The Godfather again at 64 and cried — not because the movie changed, but because I finally understood that the films we watched in our twenties weren’t just entertainment, they were instruction manuals for masculinity, family, and honor that shaped every major decision I ever made
Last week, I found myself alone in my living room, remote in hand, scrolling through streaming options when The Godfather appeared on screen. It had been years since I’d watched it. Decades, really. Something made me click play, and three hours later, I was sitting there with tears streaming down my face. Not because Sonny […]
Cincinnati Bengals 2026 NFL Draft Preview
Despite having undeniable star power, the 2025 season was the worst for the Cincinnati Bengals since Joe Burrow‘s rookie season in 2020. From August to December, Cincinnati fans had to put up with one of the worst defenses in the league, a still-struggling offensive line and questionable play calling. Bengals Draft Picks: Thankfully, the Bengals […] The post Cincinnati Bengals 2026 NFL Draft Preview appeared first on The Lead.
How a Louisiana lawyer from the 1800s appeared in the legal fight over birthright citizenship
WASHINGTON — U.S. Supreme Court justices are considering two cases that could change long-established constitutional interpretations concerning race — and Louisiana plays an integral role in both.
Health and government groups spend millions advertising on websites that promote misinformation, sometimes unintentionally
For years, health and government organizations have spent millions of dollars on advertising that appeared on websites that regularly promote health misinformation — financially supporting this growing health threat, sometimes inadvertently.
Still Alive: Bobrovsky Comes Up Big, Florida Panthers Sweep Bruins
SUNRISE — The Florida Panthers always seem to get up for the Boston Bruins. They certainly did on Thursday night. […] This article: Still Alive: Bobrovsky Comes Up Big, Florida Panthers Sweep Bruins originally appeared on Florida Hockey Now.
Nuggets Desperately Need “Playoff Jamal Murray” to Win Another Ring
In the summer of 2023, the Denver Nuggets were on top of the NBA world, defeating the Miami Heat to claim the Larry O’Brien Trophy. Denver took down Anthony Edwards‘ Timberwolves, Kevin Durant‘s Suns, and LeBron James‘ Lakers en route to its first championship in franchise history. Three-time NBA MVP Nikola Jokić took home Finals MVP, […] The post Nuggets Desperately Need “Playoff Jamal Murray” to Win Another Ring appeared first on The Lead.
Chancellor Miranda authors Science editorial
Her article, “Higher education must bridge the AI gap,” appeared Thursday, April 2.
It’s Simple, Really: Red Wings Just Can’t Score
The post It’s Simple, Really: Red Wings Just Can’t Score appeared first on Detroit Hockey Now. There are myriad reasons why the Detroit Red Wings find themselves adrift and on the outside looking in when it […] The post It’s Simple, Really: Red Wings Just Can’t Score appeared first on Detroit Hockey Now.
Sharks Locker Room: Team of Destiny?
Randy Hahn said it. View this post on Instagram And maybe, just maybe, after a five-game losing streak around the Olympics and a recent six-game skid that really shook the faith…maybe the San Jose Sharks are a team of destiny? With 28 seconds to go, the Sharks edged the Anaheim Ducks 4-3, for their third-straight […] The post Sharks Locker Room: Team of Destiny? appeared first on San Jose Hockey Now.
The Chicago Blackhawks Are Closer to Contention Than They Seem
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‘Blue Bloods’ Actor & Comedian Alex Duong Dies at 42
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Green Bay Packers 2026 NFL Draft Preview
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Rep. Sheila Cherfilus-McCormick appears before House Ethics for rare public hearing
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Orlov Offers Winning Wisdom Amidst Sharks’ Losing Streak (+)
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Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Sony PlayStation Network down: PS5 users report widespread server issues; 'please fix it'
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Letai: “From this point forward, it really is much more like business as usual at the NCI.”
NCI Director Anthony Letai appeared before the National Cancer Advisory Board Committee March 17 to maneuver through thorny topics while reiterating his message of reassurance: Stability. Stability. Stability. NCI is sturdy and will weather the storms. “The mission hasn’t changed at the National Cancer Institute,” Letai said in his remarks to the committee. “The resources […]
“Loyal Slaves” and Campfire Entertainment in Frank Vizetelly’s Confederate Camp
Frank Vizetelly’s illustration titled “Night Amusements in the Confederate Camp” appeared in the Illustrated London News on January 10, 1863. It was one among a number of wartime scenes that Vizetelly captured for the newspaper. Subscribe Following the war, the illustration appeared in a number of books, including John O. Casler’s Four Years in the Stonewall Brigade (1893) and Campfires of the Confederacy (1898) by Ben La Bree. The scene depicts a Confederate camp at night with an enslaved man, most likely a camp servant, performing a dance around a fire with the music provided by a soldier playing a banjo. Another enslaved man looks on at the right. Vizetelly likely witnessed the scene—one that would have been common throughout the war. It’s a wonderful example of the way in which Confederates—slaveowners and nonslaveowners alike—experienced the presence of slave labor in the army. Vizetelly was deeply sympathetic to the Confederate cause. His depiction of the enslaved man as more than happy to entertain the very people who were fighting to keep him enslaved was precisely the kind of image designed to reassure a British audience that slavery was benign, and by implication, that Britain need not feel morally troubled about recognizing or supporting the Confederacy. Share Just as importantly, the sight of a dancing slave reassured Confederates themselves that the institution of slavery remained secure even after President Lincoln signed the Emancipation Proclamation. I’ve come across this illustration many times before and I plan on using it in my next book project on the role of enslaved labor in the Confederate army during the Gettysburg Campaign, but this is not the reason I am sharing it with you today. It has to do with where I recently found it, which came as a complete surprise and is incredibly revealing. Let’s take a look.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
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