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Dollywood adds another race weekend for runners. When, how to sign up

Dolly Parton's theme park will host a second race weekend later this year after the inaugural spring event nearly sells out.

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Mar 27 • 5:02 AM EDT • Entertainment • knoxnews.com
NCAA’s SCORE Act comes with constitutional and moral traps

If you watched college football last season, you saw a lot of TV ads asking fans to call Congress to support SCORE Act. Expect more in March Madness.

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Mar 26 • 4:04 PM EDT • Sports • usatoday.com
Health officials begin contact tracing after new Shasta County measles case, risk low

A new measles case has been confirmed in Shasta County following 9 previous cases identified in late-January, according to the Shasta County Health and Human Se

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Mar 26 • 12:58 PM EDT • Health • krcrtv.com
'Cicada' COVID-19 variant spreading. What to know in Michigan

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Mar 26 • 8:58 AM EDT • Health • freep.com
Distinguished Binghamton Professor and Nobel laureate elected AAAS Fellow

Distinguished Professor of Chemistry M. Stanley Whittingham elected for his decades of lithium-ion battery research

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Mar 25 • 8:00 PM EDT • Science • binghamton.edu
Lana Condor talks ‘Pretty Lethal,’ Pacific Northwest-set ‘Whodunnit’

Lana Condor gets to utilize her dance skills in the action thriller "Pretty Lethal," which is now streaming on Prime Video.

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Mar 25 • 5:00 PM EDT • Entertainment • yakimaherald.com
Startups juice carbon removal with power generation

The era of relying on carbon removal revenue alone is over.

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Mar 25 • 1:45 PM EDT • Business • axios.com
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Glyphosate: A story of science, risk, and nuance

In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe

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Mar 25 • 10:25 AM EDT • Science • yourlocalepidemiologist.substack.com
Sports Illustrated Stadium to host fan events during FIFA World Cup

Sports Illustrated Stadium will host fan events — unaffiliated with the 2026 FIFA World Cup — during the world's largest sporting event.

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Mar 25 • 4:31 AM EDT • Sports • northjersey.com
NHL games today: Schedule, odds, how to watch for March 25

Here's the full NHL schedule, for March 25, including game times, TV channels, scores, odds and how to stream.

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Mar 25 • 4:28 AM EDT • Sports • usatoday.com
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Sphere Entertainment (SPHR) Stock Trades Up, Here Is Why

Shares of content production and distribution company Sphere Entertainment (NYSE:SPHR) jumped 3.1% in the afternoon session after positive analyst sentiment and a rating upgrade from an investment analysis firm fueled investor optimism.

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Mar 24 • 10:04 PM EDT • Entertainment • finance.yahoo.com
8 new emojis arrive in Apple iOS 26.4 update for iPhone users

Along with eight new emojis, the latest Apple iPhone and iPad software update includes new Apple Music features such as AI-generated playlists.

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Mar 24 • 9:36 PM EDT • Technology • usatoday.com
Crystal Festival brings sparkle, science, and family fun to Mt. Pleasant

MT. PLEASANT — A weekend filled with discovery, creativity, and hands-on fun is coming to Sanpete County as the Crystal Festival returns this spring with an exciting lineup of activities for all ages. The Crystal Festival — A Rocks, Minerals, Gems, & Crystal Show — will take place April 4–5, 2026, at the Mt Pleasant […]

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Mar 24 • 8:00 PM EDT • Science • heraldextra.com
Organized Money: The Business of Betting on Murder with Sen. Chris Murphy

Bet you can’t guess who is insider trading the Iran War.

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Mar 24 • 1:54 PM EDT • Business • prospect.org
Antoine Griezmann to join Orlando City in MLS when Atletico Madrid season ends: Why 35-year-old is still great

Griezmann, a World Cup winner with France in 2018, joins an influx of star players like Lionel Messi and Son Heung-min in MLS

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Mar 24 • 11:45 AM EDT • Sports • cbssports.com
Josh Shapiro endorses James Malone in key Lancaster County Senate race

Gov. Josh Shapiro has officially endorsed James Malone’s bid for reelection in the Lancaster County state Senate district that both parties say could determine party control next year.

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Mar 24 • 5:00 AM EDT • Politics • lancasteronline.com
UGA student turns mahjong passion into growing business: Marejong

University of Georgia student Mary Dalton Dowdy started her own business, Marejong, teaching mahjong lessons in Athens, Jefferson, Watkinsville and Wrens, Georgia. She found a unique market, becoming one of

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Mar 24 • 5:00 AM EDT • Business • redandblack.com
High school sports results for Monday, March 23, 2026

MONDAY’S RESULTS Baseball WPIAL CLASS 5A Section 1 Latrobe 13, Penn-Trafford 12 Plum 9, Armstrong 3 WPIAL CLASS 3A Section 3 Deer Lakes 10, Southmoreland...

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Mar 23 • 11:15 PM EDT • Sports • post-gazette.com
Grizzlies never threaten Hawks as Memphis falls to Atlanta

The tank was strong for the Grizzlies in Atlanta.1-11 in 12 games. PHEW.

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Mar 23 • 9:40 PM EDT • Sports • sports.yahoo.com
Business - Oil plunges, stocks surge on Trump's Iran reprieve
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Mar 23 • 5:35 PM EDT • Business • france24.com
Federal judge sides with Wisconsin in transgender health care suit

A U.S. judge ruled in favor of Wisconsin and 20 other states challenging a Trump administration declaration that tried to limit care for trans youth.

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Mar 23 • 3:23 PM EDT • Health • jsonline.com
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Expanded NICU offers families privacy, innovation

The NICU at Temple Health's new Women and Families Hospital offers twice the space and many more services than its predecessor.

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Mar 23 • 1:39 PM EDT • Health • 6abc.com
Antarctica could warm 1.4 times faster than the rest of the Southern Hemisphere in the coming decades, study finds

Antarctica could warm much faster than its surroundings over the next few decades due to a phenomenon known as polar amplification that is well established in the Arctic.

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Mar 23 • 12:13 PM EDT • Science • livescience.com
Health in a Handbasket: Chips & Dip

Today we're putting a healthy spin on a snack we all know and love.

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Mar 23 • 9:04 AM EDT • Health • 13wham.com
Connections: Sports Edition today: Hints and answers for March 23, 2026, puzzle No. 546

Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.

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Mar 23 • 12:50 AM EDT • Sports • nytimes.com
Vermont may look across borders to help bring in business

House passes bill to create sister state program for economic development.

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Mar 22 • 8:55 PM EDT • Business • wcax.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Everything you need to know about the ‘Hannah Montana 20th Anniversary Special’ — How to watch, premiere time, who’s coming back and more

Sweet niblets! Hannah Montana is back for an anniversary special. Here's what to know.

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Mar 22 • 12:00 PM EDT • Entertainment • yahoo.com
Lancaster County public sales: March 22, 2026

Beiler-Campbell Auction Services conducted a public auction of real estate March 9 for Stanley and Debora Miller at 2788 N. Colebrook Road, Manheim. A four-bedroom house with attached garage and

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Mar 22 • 7:00 AM EDT • Business • lancasteronline.com
Politics: Iowa Senate majority leader outlines plans for coming weeks

Second funnel week concluded in the Iowa Legislature, meaning that lawmakers’ focus can return to funding, appropriations and other types of specific bills that don’t respond to the Legislature’s self-imposed

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Mar 22 • 2:00 AM EDT • Politics • telegraphherald.com
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Paxton Aaronson scores twice to propel Rapids to 4-1 victory over Sporting KC

Paxton Aaronson scored a goal in each half, Wayne Frederick's first career goal was the go-ahead score and the Colorado Rapids rolled to a 4-1 victory over Sporting Kansas City on Saturday night. Aaronson gave Colorado (3-2-0) the lead in the 12th minute, but Shapi Suleymanov scored for the first time this season — in the 44th — to pull Sporting KC (1-3-1) even. The tie lasted until the second minute of stoppage time when Frederick scored unassisted for a 2-1 lead at halftime.

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Mar 22 • 1:40 AM EDT • Sports • sports.yahoo.com
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Apple Has Unveiled 9 New Products This Month

Apple has unveiled a whopping nine new products so far this March, including an iPhone 17e, iPad Air models with the M4 chip, MacBook Air models with the M5 chip, MacBook Pro models with M5 Pro and M5 Max chips, the all-new MacBook Neo, an updated Studio Display, a higher-end Studio Display XDR, AirPods Max 2, and Nike Powerbeats Pro 2.

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Mar 20 • 5:39 PM EDT • Technology • macrumors.com
US House Democrat blasts Commerce's 'highly concerning' $1.6 billion USA Rare Earth deal

A senior House Democrat accused U.S. Commerce Secretary Howard Lutnick on Thursday of structuring Washington's $1.58 billion investment into USA Rare Earth ​in a way that gives the government "highly concerning" leverage over the company while boosting Lutnick's family-run investment firm.

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Mar 20 • 12:30 PM EDT • Business • reuters.com
March Madness Day 1: Duke survives scare as UNC, Wisconsin, AJ Dybantsa go down on Thursday
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Mar 20 • 9:47 AM EDT • Sports • sports.yahoo.com
Who is Nate Burleson? Why has he replaced Ernie Johnson for NCAA Tournament?

Where is Ernie Johnson? Who is Nate Burleson? Here's what you need to know about CBS and TNT Sports' studio hosts for NCAA Tournament.

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Mar 20 • 8:29 AM EDT • Sports • usatoday.com
Marmite maker Unilever in talks to merge food business with US-based McCormick

Group, which also owns Dove and Hellmann’s, will focus more on personal care products if deal agreed

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Mar 20 • 5:40 AM EDT • Business • theguardian.com
Firefighters battling flames on roof of building housing row of businesses in Midwood

FDNY officials say a fire was reported in a restaurant at 1021 Avenue H between East 10th Street and Coney Island Avenue around 4:40 p.m.

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Mar 19 • 6:06 PM EDT • Business • abc7ny.com
Florida GOP’s divisions, cancel culture and Alligator Alcatraz: IFP

Turns out Florida state lawmakers can't approve budget, but they do like cancel culture. And how much has the state spent on Alligator Alcatraz?

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Mar 19 • 2:50 PM EDT • Politics • usatoday.com
Mobile sports betting dies again in Mississippi Senate

It is the second time this session that a mobile sports betting bill from the House has died in the Senate.

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Mar 19 • 1:40 PM EDT • Sports • magnoliatribune.com
March Madness 2026 live updates: Where to watch NCAA basketball today, time, channel, what to know

Follow March Madness live as the 2026 NCAA men's basketball tournament kicks off with major matchups and potential upsets across the country.

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Mar 19 • 8:53 AM EDT • Sports • nbcnews.com
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Cone Health to Cut Ribbon on Two New Mobile Health Units

Two New Mobile Units Launch To Meet The Needs of the Community

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Mar 19 • 8:00 AM EDT • Health • conehealth.com
Customers help Denver small business owner relocate after 60-day vacate notice
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Mar 18 • 11:08 PM EDT • Business • cbsnews.com
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Healthy Returns: Stopping GLP-1s raises risk of heart attack, stroke and death, study says

Research finds that even short gaps in treatment with a GLP-1 can drive up risks of heart attack, stroke and death in patients with Type 2 diabetes.

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Mar 18 • 2:06 PM EDT • Health • cnbc.com
From The Sports Desk: Venezuela shows why World Baseball Classic matters

And six prime-time players to watch during March Madness.

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Mar 18 • 10:02 AM EDT • Sports • nbcnews.com
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7 events in Lancaster County this weekend, from a plant shop reopening to Zenkaikon

Spring starts this Friday, and there are plenty of ways to celebrate its arrival through the arts scene in Lancaster County this week.

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Mar 18 • 5:00 AM EDT • Entertainment • lancasteronline.com
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Georgia WBB on 'a business trip' in Iowa City for March Madness

For Georgia women's basketball coach Katie Abrahamson-Henderson, Saturday is just another business trip. Here's why.

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Mar 18 • 4:02 AM EDT • Business • onlineathens.com
Meet the Mid-Penn Conference winter sports all-stars

See who made the Mid-Penn Conference all-star winter teams in basketball and wrestling.

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Mar 18 • 4:01 AM EDT • Sports • sports.yahoo.com
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How sports traditions like March Madness can support brain health

Three experts from the University of Kentucky say the answer may be yes. Research shows that staying mentally, socially and emotionally engaged can help support long-term brain health. Activities tied to sports — like predicting tournament outcomes, reminiscing about past games or gathering with friends and family to watch — can stimulate memory, strengthen cognitive skills and foster meaningful social connections.

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Mar 18 • 4:00 AM EDT • Sports • uknow.uky.edu
Trump said he wanted one of the Texas Senate candidates to drop out. Now he’s missed the deadline

President Donald Trump promised his endorsement was forthcoming in the GOP Texas Senate runoff and said he wanted whoever he didn’t pick to drop out. But now — preoccupied with the Iran war and a doomed voting bill — he’s missed a critical deadline.

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Mar 17 • 6:08 PM EDT • Politics • cnn.com
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House passes 5-year reauthorization to fund small business tech programs

Funding for the SBIR and STTR programs lapsed five months ago. The Senate this month passed a bipartisan bill to fund the programs through Sept. 30, 2031.

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Mar 17 • 5:30 PM EDT • Business • fedscoop.com
Quincy, GREDF now accepting RFQs for sports complex project

The City of Quincy is now taking the next step on an indoor sports complex proposal for 48th and Maine St.

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Mar 17 • 5:23 PM EDT • Sports • khqa.com
Legalized online sports betting faces pushback before key vote

Opponents of a bipartisan bill to legalize online sports betting in Wisconsin continue to push back as the proposal is set for a vote in the Senate.

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Mar 17 • 6:04 AM EDT • Sports • jsonline.com
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Women’s Health Research Advancing at UConn

40 research abstracts presented at 3rd annual women’s health-focused research symposium of The Group on Women in Medicine and Science of the UConn School of ...

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Mar 16 • 2:29 PM EDT • Health • today.uconn.edu
Scott Borchetta launches Borchetta Entertainment Group management division with Carly Pearce signing

Borchetta’s departure from HYBE AMERICA was announced in February.

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Mar 16 • 11:43 AM EDT • Entertainment • musicbusinessworldwide.com
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Iran's Political Prisoners Are in Danger From U.S.-Israeli Strikes

Thousands of detainees are in danger from U.S. and Israeli strikes and Tehran’s vengeance.

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Mar 16 • 7:00 AM EDT • Politics • foreignpolicy.com
The Latest: The 2026 Academy Awards get underway

The wait in Hollywood is over: The 98th Academy Awards are underway. Comedian Conan O’Brien is back for a second year to host the ceremony on Sunday, held at the

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Mar 15 • 8:16 PM EDT • Entertainment • lancasteronline.com
Trump's war rhetoric is coarse. It's also heard differently, depending on the audience

President Trump and other administration officials have projected confidence and power in Iran in a coarse tone that is unprecedented, according to experts in wartime rhetoric.

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Mar 15 • 6:00 AM EDT • Politics • latimes.com
What do Maine’s fishermen and restaurateurs have in common? Mental health challenges.

Both our fishing and restaurant sectors shoulder extraordinary strain. If we them to endure here, we must take that into account.

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Mar 15 • 4:00 AM EDT • Health • pressherald.com
Politics: Iowa nonpartisan group predicts bigger budget shortfall than expected

Iowa will likely operate on a near-$1.3 billion budget deficit over the next fiscal year, according to the latest report from state officials.

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Mar 15 • 2:00 AM EDT • Politics • telegraphherald.com
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Big Ten hockey: Michigan thumps Penn State, advances to final

Michigan defeated Penn State, 5-2, in a Big Ten hockey tournament semifinal at Ann Arbor Saturday night, clinching a spot in the championship game.

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Mar 14 • 9:55 PM EDT • Sports • sports.yahoo.com
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Titans agree to restructure Calvin Ridley's contract for 2026

The Tennessee Titans and wide receiver Calvin Ridley have agreed to restructure his contract ahead of the 2026 season.

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Mar 14 • 9:42 PM EDT • Sports • sports.yahoo.com
Valley business evacuated after bomb threat
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Mar 14 • 9:19 PM EDT • Business • 12news.com
2026 NFL mock draft: Broncos add massive defensive lineman

The Broncos select a massive defensive lineman in this 2026 NFL mock draft.

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Mar 14 • 11:00 AM EDT • Sports • sports.yahoo.com
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Contributor: Federal power grabs on elections are not about fraud

Trump has called the SAVE Act his top priority. But why? His commission found no widespread problem that needed solving.

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Mar 14 • 6:00 AM EDT • Politics • latimes.com
Evidence mounts suggesting health costs from WV lawmaker moves on data centers, water

In a span of less than half an hour March 12, 2026, the West Virginia House of Delegates made three moves undermining the state’s already poor drinking water quality. Moves the House of Delegates and Senate have made in the 2026 legislative session's final days are likely to inflict significant health costs, recent studies suggest.

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Mar 14 • 5:30 AM EDT • Health • wvgazettemail.com
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Figuring out why AIs get flummoxed by some games

When winning depends on intuiting a mathematical function, AIs come up short.

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Mar 13 • 5:47 PM EDT • Technology • arstechnica.com
HOMETOWN ENTERTAINMENT: “Buddies” opens Friday in downtown Roanoke

Roanoke community theater Exit, Pursued By A Bear opens Buddies, a new play by Hollins MFA grad Ben Abbott, tonight at 7.

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Mar 13 • 3:00 PM EDT • Entertainment • wdbj7.com
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Micah Bob Finds His Foundation in Materials Science

UC Davis materials science and engineering student Micah Bob studies sustainable cement alternatives to reduce carbon emissions. As graduation approaches, he reflects on the transformative course, research experiences and campus life — including MASC and Video Game Orchestra — that shaped his journey.

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Mar 13 • 1:04 PM EDT • Science • engineering.ucdavis.edu
After firings, funding cuts, and a shooting, can a demoralized CDC workforce recover?

It's been a year since mass firings began at the CDC, the federal public health agency. Then came a shooting, and the government shutdown. Atlanta is still feeling the economic and emotional effects.

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Mar 13 • 12:54 PM EDT • Health • npr.org
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Lancaster County public sales: March 13, 2026

Witman Auctioneers Inc., of Manheim conducted a public auction of real estate March 5 for the trust of Kathleen March at 644 Symphony Woods Drive, Silver Spring, Maryland. A four-bedroom

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Mar 13 • 7:00 AM EDT • Business • lancasteronline.com
Watch HC Bucky McMillan's postgame presser after losing to Oklahoma

Bucky McMillan identified just what went wrong in Texas A&M's SEC tournament opening loss to Oklahoma.

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Mar 13 • 5:16 AM EDT • Sports • sports.yahoo.com
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I Watched My Father's Million-Dollar Business Fail — Here's What It Taught Me About Business

My father's restaurant hit $1 million in revenue and still went bankrupt. I was 11, and those lessons shaped every company I've built since.

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Mar 12 • 1:30 PM EDT • Business • entrepreneur.com
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White House Uses ‘Wii Sports’ Imagery In Iran War Video—After Usage Of ‘Pokémon’ Sparked Rebuke

The “Wii Sports” video was posted days after The Pokémon Company said it did not give permission to the White House to use imagery from “Pokémon Pokopia” in a social media post.

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Mar 12 • 12:17 PM EDT • Sports • forbes.com
Silence is not golden when it comes to science and AI

The scope of scientific inquiry is contracting as research focuses on data-rich problems

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Mar 12 • 11:58 AM EDT • Science • ft.com
Birmingham playing for Division III state hoops title after losing early in City playoffs

The Patriots regrouped after losing in the City Section playoffs to advance to play Antioch Cornerstone Christian for the title on Friday.

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Mar 12 • 7:15 AM EDT • Sports • latimes.com
My Year as a Degenerate Sports Gambler

My year as a degenerate gambler

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Mar 12 • 6:00 AM EDT • Sports • theatlantic.com
Team USA advances at 2026 World Baseball Classic despite shocking loss to Italy

Italy beat Team USA on Tuesday night and then helped the Americans on Wednesday by defeating Mexico

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Mar 11 • 10:18 PM EDT • Sports • cbssports.com
Why Cowboys, 49ers pulled off trade involving Osa Odighizuwa

Why did the Dallas Cowboys trade Osa Odighizuwa to the San Francisco 49ers? Find all the answers on the trade here.

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Mar 11 • 6:37 PM EDT • Sports • sports.yahoo.com
Nonprofit clinics offer crucial lifeline to Georgians living without health insurance

Across Georgia, nonprofit clinics like Good Shepherd in Clayton County are stepping up to provide free medical services for the state's 1.2 million uninsured.

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Mar 11 • 6:21 PM EDT • Health • cbsnews.com
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Beyond The Burn Zone: Maui Wildfires Cause Widespread Mental Health Issues

New research shows housing displacement and income loss were central drivers of psychological harm.

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Mar 11 • 5:19 PM EDT • Health • civilbeat.org
Italy GM Ned Colletti gets emotional over 'sports miracle' in WBC

Team Italy GM Ned Colletti was still emotional after the country's stunning upset win against Team USA in the World Baseball Classic.

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Mar 11 • 11:16 AM EDT • Sports • usatoday.com
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Iran cannot participate in the FIFA World Cup, sports minister says

Iran says 'under no circumstances' will it participate following the US-Israeli attacks that killed its supreme leader.

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Mar 11 • 9:27 AM EDT • Sports • aljazeera.com
Mobile brain scans sound like science fiction. But they're now helping more Canadian patients

A rising number of Canadian facilities are using mobile brain scanners to help patients, by offering MRIs mid-surgery in hospital or diagnosing stroke right on the roadside. So what's the future of this game-changing technology?

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Mar 11 • 4:00 AM EDT • Science • cbc.ca
Ravens cancel Maxx Crosby trade after failed physical: Analysis

The Ravens backed out of their blockbuster trade for Raiders star Maxx Crosby after he failed his physical, voiding the deal that would have cost Baltimore two first-round picks.

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Mar 10 • 8:22 PM EDT • Sports • sports.yahoo.com
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Igor Tudor: Pressure grows as Antonin Kinsky experiment backfires and raises further questions over Spurs head coach
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Mar 10 • 7:15 PM EDT • Sports • skysports.com
MidEast conflict could hurt Chinese business

Analysts say China may benefit geopolitically from a prolonged Iran war, but it could start to feel the pain economically.

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Mar 10 • 6:08 PM EDT • Business • finance.yahoo.com
8 new emojis are coming to Apple products with iOS 26.4. Take a look.

New emojis include ballet dancers, a distorted face, a fight cloud, a sasquatch-like creature, a landslide, an orca, a trombone and a treasure chest.

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Mar 10 • 5:54 PM EDT • Technology • usatoday.com
Health Care Heroes honored in Rochester

The event recognized 39 organizations and individuals in the area who have made a difference in local health care.

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Mar 10 • 4:35 PM EDT • Health • 13wham.com
Can Trump run a war and a midterm campaign at the same time?

The push-and-pull between the Iran conflict and the November elections is contributing to mixed messages now and difficult choices ahead.

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Mar 10 • 3:16 PM EDT • Politics • usatoday.com
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‘Be Amazing’ business-supported fundraiser to be held Thursday

More than 50 businesses are participating the 9th ‘Dine out and Shop Around’ fundraiser for Be Amazing.

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Mar 10 • 11:15 AM EDT • Business • wsaw.com
How Portland's business challenges ripple across Oregon

The city's economic growth depends on restoring livability.

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Mar 10 • 9:20 AM EDT • Business • axios.com
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Prep talk: Bell's baseball team is surging with 8-1 record

After winning City title in 2024, Bell's baseball team returns to its winning ways this season and has picked up some big victories already.

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Mar 10 • 7:00 AM EDT • Sports • latimes.com
Did Ravens Overpay for Maxx Crosby? Veteran Insider Explains

When the Baltimore Ravens reportedly sent two first-round picks to the Las Vegas Raiders for star pass rusher Maxx Crosby, the move immediately stunned the league. Not only was the price steep, but it also broke from Baltimore’s long-standing philosophy.

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Mar 10 • 2:33 AM EDT • Sports • sports.yahoo.com
India face Chinese Taipei in women's Asian Cup: Indian Sports LIVE, March 10

Here are all the updates from Indian sports on March 10, 2026.

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Mar 9 • 10:50 PM EDT • Sports • espn.com
Trump administration widens its 2020 election probe as it obtains records from Arizona

The Republican leader of Arizona's state Senate said Monday he has handed over records related to the 2020 presidential election to the FBI in the latest sign that the Trump administration is acting on the president's longstanding falsehoods about a race he lost to Democrat Joe Biden.

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Mar 9 • 8:18 PM EDT • Politics • pbs.org
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Neil deGrasse Tyson weighs in on aliens, "space jellyfish," movie science and Pluto
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Mar 9 • 5:07 PM EDT • Science • cbsnews.com
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7 big political questions about the war with Iran

As the Iran war enters its second week, here are the top questions shaping US political debate and what comes next.

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Mar 9 • 2:37 PM EDT • Politics • cnn.com
How US-Israeli war on Iran is upending global business

The U.S.-Israeli war with Iran is rattling businesses worldwide, driving up energy prices, squeezing supplies of critical raw materials and raising questions about the reliability of trade routes critical to the flow of goods from food to car parts.

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Mar 9 • 12:02 PM EDT • Business • reuters.com
Cartesian Therapeutics Reports Full Year 2025 Financial Results and Provides Business Update

Enrollment continues to progress in Phase 3 AURORA trial of Descartes-08 in myasthenia gravis Phase 2 TRITON trial of Descartes-08 in dermatomyositis and antisynthetase syndrome, expected to initiate in 1H26 Phase 1/2 HELIOS pediatric trial of Descartes-08 in juvenile dermatomyositis actively enrolling Approximately $126.9 million cash, cash equivalents and restricted cash as of December 31, 2025, expected to support planned operations into mid-2027, including completion of ongoing Phase 3 AUROR

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Mar 9 • 7:00 AM EDT • Business • finance.yahoo.com
Bam Adebayo joins Dwyane Wade in Miami Heat history books

Some franchise history for Adebayo.

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Mar 9 • 12:01 AM EDT • Sports • sports.yahoo.com