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New data shows consumers dropped health coverage after Republicans let subsidies expire
Republican officials don’t deny the accuracy of the data, though they’ve repeatedly tried to argue that the reduction is a positive development. It’s not.
A $1000 PlayStation 6 No Longer Sounds Crazy, As Sony Doesn’t Intend To Sell Hardware At Significant Losses
The PlayStation 6 is set to launch at one of the most challenging times for consumer tech, if not the most challenging. With the rising prices of components, RAM and SSDs above all, manufacturers are having an extremely hard time keeping costs down, and with a bill of materials that is now close to $1000, there's a very high chance the system will cost way more than most anticipated. Adding fuel to the fires of speculation is Sony itself, as the company heavily suggested in a recent investor Q&A session that it won't heavily subsidize the system. "We regard hardware as the base […]
T-Mobile Is Automatically Pushing Legacy Customers Onto Its Current Plans
Some long-time subscribers could see a price increase of around $4 a line.
Talawar Therapeutics and JATT II Acquisition Corp. Announce Definitive Business Combination Agreement to Create Publicly Listed Biotechnology Company Developing Potentially Best-in-Class Bispecifics for I&I Diseases
Oversubscribed $225 million concurrent private investment in public equity ("PIPE") with available cash to the combined company at closing anticipated to fund...
Comcast to split cable business from media through NBCUniversal, Sky spinoff
Comcast will split into two publicly traded companies through a spinoff of NBCUniversal and Sky, separating its cash-generating broadband arm from a media and entertainment business under pressure from streaming rivals and industry consolidation. The latest U.S. media industry shake-up follows years of cord-cutting as legacy players chase scale to better compete with Netflix while Paramount Skydance's $110 billion deal for Warner Bros Discovery is set to boost competition. Comcast, which leans on cable for much of its cash flow, is also losing broadband customers to fixed wireless offerings from T-Mobile and Verizon and to fiber rivals building out networks.
Is it true that … vitamin C serums provide added sun protection?
This antioxidant may enhance the protection sunscreens provide, but it is no substitute for them
Colorado’s regulations should address policy challenges only as truly needed
As Colorado approaches its 150th birthday, we should remember its first 100 years were characterized by repeated boom-and-bust economic cycles. Dependence on mineral extraction and agricultural commodity prices was subject to the volatility of these markets. In 1972, as I arrived in Denver with Ma Bell, 40,000 metro households were waiting for dial tone since […]
Millions drop Obamacare health coverage after subsidies expire and costs rise
Health analysts say the drop in enrollment was likely related to the Jan. 1 expiration of federal subsidies, which caused a surge in plan costs that resulted in many people being unable to pay their premiums.
AB Science reports completion of the step 3 of phase 1, evaluating the combination of AB8939 with venetoclax for the treatment of refractory or relapsed AML
PRESS RELEASE AB SCIENCE REPORTS COMPLETION OF THE STEP 3 OF PHASE 1, EVALUATING THE COMBINATION OF AB8939 WITH VENETOCLAX FOR THE TREATMENT OF REFRACTORY OR RELAPSED ACUTE MYELOID LEUKEMIA THE COMBINATION OF AB8939 WITH VENETOCLAX GENERATED A 67% OVERALL RESPONSE RATE (ORR) AND A 100% DISEASE CONTROL RATE (DCR), WITH NO DOSE-LIMITING TOXICITIES (DLT) OBSERVED, IN A POOR-PROGNOSIS POPULATION WITH ADVERSE GENETICS TREATED IN THE SECOND - TO FOURTH-LINE RELAPSED OR REFRACTORY SETTING Paris, June 2
Multiple sclerosis affects social life and work beyond physical health
Multiple sclerosis (MS) can have a substantial impact on many aspects of life beyond physical health, with 51% of people reporting that the disease affects their social life and 48% reporting that it affects their work, according to new research presented at the European Academy of Neurology (EAN) Congress 2026.
It’s the End of an Era for Xbox Game Pass, According to a New Report
A new Xbox Game Pass report has warned it is about to be the end of an era for the Microsoft subscription service.
Millions drop Obamacare health coverage after subsidies expire and costs rise
Hampton Roads Virginia and Northeastern North Carolina News, Weather, Traffic and Sports.
VSP Vision Announces Winner of Propel Student Business Challenge Scholarship
RANCHO CORDOVA, Calif.—VSP Vision, in collaboration with the Student Optometric Leadership Network (SOLN), today announced that Mason Martin, a student at the University of Alabama at Birmingham School of Optometry, is the winner of the 2026 Propel Student Business Challenge Scholarship, powered by PECAA. Martin, who was awarded the $10,000 scholarship and a travel grant to attend the SOLN conference in Denver, is the first first-year student at the school to receive this honor, the announcement said. VSP said his standout submission featured a thoughtful, patient-centered private practice business plan.
John West: Science and the American Founding
“Today, many people think that belief in a Creator is a subjective preference based on their personal faith. But that was not the view of America’s Founders.”
Concerns with the Sebastian County Sheriff’s office
The recently-surfaced video showing the potential maltreatment of a Sebastian County Jail inmate, and a subsequent statement about the troubling incident from interim Sheriff Mike Conger point to the need...
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
US Small and Midsize Businesses Poised for Growth, Waiting to Make Significant Moves: 2026 Columbia Bank Business Barometer
Rising expectations for increased productivity, profitability and growth opportunities tempered by near-term uncertainty and volatility
Serena Williams describes ‘grueling’ anti-doping rules in tennis ahead of comeback
Under WADA rules, players have to submit to a test when the doping control officer requires them, even if it is outside their window.
Manchester United’s Manuel Ugarte set for extended absence with knee ligament injury
The timeframe for any absence for the 25-year-old is subject to ongoing tests over the severity of the injury.
World Cup: the group-stage disappointments 🥶
They could still wake up... or not.This Sunday evening at 9 p.m., the knockout stage of the 2026 World Cup begins with the first round-of-32 match between Canada and South Africa.The group stage has n...
Rescheduling marijuana would put politics ahead of science
The Drug Enforcement Administration is considering a proposal to move marijuana from Schedule I to Schedule III of the Controlled Substances Act, which would recognize all cannabis products as havi…
Rescheduling marijuana would put politics ahead of science
The Drug Enforcement Administration is considering a proposal to move marijuana from Schedule I to Schedule III of the Controlled Substances Act, which would recognize all cannabis products as havi…
Ex-Google engineer says Larry Page, Sergey Brin and Sundar Pichai share the same trait—it’s the lesson he swears by as a $7.2 billion AI CEO
$7.2 billion AI founder Arvind Jain ‘observed’ Sundar Pichai at Google for years before he became CEO—he learned you need to ‘think crazy’ to be successful
International Business Machines (IBM) Is A Top Stock In Billionaire Richard Chilton’s Filings
International Business Machines Corporation (NYSE:IBM) is one of the 10 Best Stocks to Buy According to Billionaire Richard Chilton. Technology giant International Business Machines Corporation (NYSE:IBM) made a key announcement recently when it announced its 0.7-nanometer chip manufacturing technology. This technology is the most advanced chip manufacturing technology in the world. International Business Machines Corporation […]
Employment scams study reveals soaring numbers
Job hunters tricked into handing over thousands of dollars are being lured with a new tactic: task-based scams, in which they are offered high pay to “like” and “subscribe” to videos online.
Aussie sounds alarm over scary trend with smart glasses: 'People have no idea'
It's being dubbed a 'substantial' privacy risk for those not in the know.
Bernstein Says Life Science Sector is Improving, Resumes Thermo Fisher Scientific (TMO) Coverage
Thermo Fisher Scientific Inc. (NYSE:TMO) is included among Billionaire Steven Cohen’s Top 11 Dividend Stock Picks. On June 26, Bernstein resumed coverage of Thermo Fisher Scientific Inc. (NYSE:TMO) with a Market Perform rating. It also set a $520 price target after the analyst returned from maternity leave. In a research note, the firm said “Many […]
AbbVie (ABBV) Wins Health Canada Approval for Boey
AbbVie Inc. (NYSE:ABBV) is one of the 12 Most Profitable S&P 500 Stocks to Invest In. On June 23, 2026, Allergan Aesthetics, an AbbVie Inc. (NYSE:ABBV) company, announced that Health Canada approved Boey for the temporary improvement of moderate to severe lines between the eyebrows in adults. Boey is the first and only approved botulinum […]
Morgan Stanley Raises PT on International Business Machines (IBM) Stock
International Business Machines Corporation (NYSE:IBM) is one of the Best Cloud Computing Stocks to Buy According to Hedge Funds. On June 23, Morgan Stanley lifted its price objective on the company’s stock to $267 from $225, and maintained an “Equal Weight” rating on the shares. As per the analyst, Dell and HPE earnings demonstrate that the enterprise server demand […]
Starz Entertainment (STRZ) Stock Sees Fair Value Lift After Q1 Analyst Target Increases
Price targets for Starz Entertainment have shifted as the analyst fair value estimate moved from US$19.38 to US$28.50, putting a higher reference point in focus for investors tracking the stock. Recent Street research has turned more constructive after the Q1 report, with several firms lifting price targets and updating models to reflect how they now view execution risks and valuation support. In the sections that follow, you will see how to interpret these changing targets and what they...
Millions drop Affordable Care Act coverage after subsidies expired
New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year.
3 million Americans have dropped Obamacare health coverage over past year, after Republicans let federal subsidies expire
KFF expects the total number of people in the government healthcare program to continue to decline throughout the year, potentially to a low of about 17.5 million from 19.2 million now.
Millions drop Obamacare health coverage after subsidies expire and costs rise
NEW YORK — About 3 million fewer people in the United States had Affordable Care Act health insurance plans in February compared with the same time...
Deals: Prime Day shopping is over, here are the best Galaxy S26 and Pixel 10 series deals
The four-day shopping bonanza ended on Friday - now we're back to the regular, no-subscription-required deals. The four days of Amazon Prime Day shopping...
Millions drop Obamacare health coverage after subsidies expire and costs rise
About 3 million fewer people in the United States had Affordable Care Act health insurance plans in February compared with the same time last year, according to new federal data. In the report releas...
Millions drop Obamacare health plans after subsidies expire and costs rise
New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year.
Millions drop Obamacare health coverage after subsidies expire and costs rise
New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year. The Department of Health and Human Services...
Millions drop Obamacare coverage after subsidies expire, costs rise
New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year
A Clover Health Director Sold Over 67,000 Company Shares. Here's a Closer Look at the Transaction.
This healthcare technology firm, focused on Medicare Advantage plans, reported a notable insider sale amid muted stock performance.
ChaosCollage
Already teaming up for the Chaos Spreads challenge? Submit a screenshot of you and your friends in Minecraft via Gleam.io for a chance to feature in our end-of-summer chaos collage! Find out more in this article
Caesars Entertainment (CZR) Expands In Maine Online Gaming, Is The Stock Already Fully Valued?
Caesars Entertainment expands digital footprint with Wabanaki Nations partnership Caesars Entertainment (CZR) is extending its partnership with three Wabanaki Nations to include online casino gaming in Maine, targeting a potential 2026 iGaming launch, subject to regulatory approvals. See our latest analysis for Caesars Entertainment. Caesars Entertainment shares have climbed over recent months, with a 90 day share price return of 16.79% and year to date gain of 28.14%. However, the 5 year...
Mountain lions changed everything in this tiny California preserve
A surprising ecological makeover unfolded when mountain lions began frequenting a small preserve south of San Francisco. Deer activity dropped, plants recovered, and shifts among predators like coyotes, bobcats, and foxes followed. The study shows that powerful “trophic cascades” aren’t limited to remote wilderness—they can happen in small, suburban preserves too.
Colorado Politics Calendar June 29-July 5
CoPo’s weekly political calendar will help you find political and public-policy events throughout Colorado. It includes candidate and issue campaign events, public policy meetings, court hearings, state and local party conventions, assemblies, debates, rallies, parades, speaking engagements, traveling dignitary appearances, water meetings, book signings, county commission hearings, city council meetings and more. As a subscriber, […]
Chicago teacher visiting every FBS stadium while bridging gap between LGBTQ+ community, sports world
A Chicago teacher is hard at work on his quest to visit every NCAA Division I Football Bowl Subdivision stadium in America, while also strengthening bonds between the sports world and the LGBTQ+ community.
How SBT navigated the politics of GRVL
Real community engagement and substantive changes paved the way for SBT GRVL's continued success.
Congress subpoenas Leon Black during interview about Jeffrey Epstein
The House Oversight Committee issued subpoenas to billionaire Leon Black after he declined to answer questions about non-disclosure agreements.
Walton Arts Center to host blood drive with free entertainment July 1
The Walton Arts Center will host a blood drive in partnership with the American Red Cross from 10 a.m. until 4 p.m. on Wednesday, July 1. The center will provide live entertainment for blood donors in attendance that day, including performances by cellist Carrington Truehart, and guitarists Ben Harris and William Reyes. SUBSCRIBE: Get our
PepsiCo Q2 earnings expected to reflect weakness in North American snack business, delayed recovery
PepsiCo Inc (NASDAQ:PEP, XETRA:PEP) earnings outlook was trimmed by Bank of America analysts ahead of the company’s second quarter results, with softer-than-expected performance in its North American snacks business offsetting steadier international trends. The analysts lowered their fiscal...
CSUF Report Finds Family Businesses Drive Jobs and Revenue in Fullerton
The city of Fullerton is home to a vibrant entrepreneurial community, with family-owned businesses serving as a cornerstone of the local economy. The family business sector in Fullerton is the subject of a new report researched and published by Tim Schultz, the head of Cal State Fullerton’s Center for Family Business. Chethan Srikant, associate professor […]
PENN Entertainment (PENN) Just Overtook the 20-Day Moving Average
Should investors be excited or worried when a stock crosses above the 20-day simple moving average?
Warren Buffett Bought A Business For $1.7B ‘Over The Phone Without Ever Meeting The People There’ Using The ‘Most Valuable Skill’ He Learned
Buying a company for $1.7 billion without meeting management sounds like the kind of decision that would keep lawyers busy for months. Warren Buffett did it over the phone. Speaking at the University of Nebraska-Lincoln in 2003, Berkshire Hathaway Chair...
Corus Entertainment reports $36.5M Q3 loss, revenue down 26 per cent from year ago
TORONTO — Corus Entertainment Inc. reported a net loss attributable to shareholders of $36.5 million in its latest quarter as the company behind Global Television saw its revenue fall 16 per cent compared with a year ago.
Accel Entertainment (ACEL) Expands Louisiana Gaming Footprint Through Truck Stop Casino Acquisition
Accel Entertainment, Inc. (NYSE:ACEL) ranks among the best sin stocks to buy for recession protection. On June 3, Accel Entertainment, Inc. (NYSE:ACEL) strengthened its Louisiana business with the acquisition of Rice Palace Truck Stop Casino in Crowley, adding a high-volume gaming venue that expands the company’s route-based gaming network in another of its strongest growth […]
CORUS ENTERTAINMENT ANNOUNCES FISCAL 2026 THIRD QUARTER RESULTS
CorusEntertainmentInc. (TSX: CJR.B) announced its third quarter financial results today.
Slate's $24,950 EV truck is tiny and ridiculously customizable
Slate's pickup truck just revealed its sub-$25k price. So we tested out its build-your-own tool to see how the accessories work.
It's Xbox's turn (again), as console prices keep going up
Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.
Politics Chat, June 25, 2026
A newsletter about the history behind today's politics.
College Sports Commission to continue reviewing deals by multimedia rights companies
A judge ruled that multimedia rights companies that represent university athletic departments can continue to be subject to the same rules governing millions in third party name-image-likeness payments to players that are reshaping college sports.
College Sports Commission to continue reviewing deals by multimedia rights companies
A judge ruled that multimedia rights companies that represent university athletic departments can continue to be subject to the same rules governing millions in third party name-image-likeness payments to players that are reshaping college sports.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Entrepreneurs pitched business ideas to Yahoo Finance
Yahoo Finance Executive Editor Brian Sozzi is on the hunt for the next big business breakthrough. Check out the absolute best pitches and standout moments from the innovators making waves at Cannes Lions.
NASA Selects Rocket Lab to Launch Sun, Earth Science Missions
NASA has selected Rocket Lab to provide the launch service for both the agency’s PolSIR (Polarized Submillimeter Ice-cloud Radiometer) and Total and Spectral Solar Irradiance Sensor-2 (TSIS-2) missions.
Scientists find molecular-level evidence for two structures in liquid water
A study published in Nature Physics provides new molecular-level evidence from simulations that liquid water is not a single uniform substance, but a constantly shifting mixture of two distinct microscopic ...
http://democrats-energycommerce.house.gov/media/press-releases/pallone-opening-remarks-health-subcommittee-markup-15-bills
Energy and Commerce Committee Ranking Member Frank Pallone, Jr. (D-NJ) delivered the following opening remarks today at a Health Subcommittee markup of 15 bills:
How Caesars’ Expanded Tribal iGaming and Community Partnership Could Shape Caesars Entertainment (CZR) Investors’ Outlook
In June 2026, Caesars Entertainment Inc. announced that it had expanded its partnership with three Wabanaki Nations in Maine to cover online casino gaming, aiming to launch Caesars Palace Online Casino, Caesars Sportsbook & Casino and Horseshoe Online Casino in 2026, subject to regulatory approval and integrated with Caesars Rewards and a universal digital wallet. A distinctive element of this agreement is Caesars’ commitment to employ and train tribal members while providing financial...
Health Subcommittee Markup of 15 Bills Addressing Illicit Drugs and Health Care Price Transparency
The Committee on Energy and Commerce is the oldest standing legislative committee in the U.S. House of Representatives and is vested with the broadest jurisdiction of any congressional authorizing committee.
JD Sports Upgrades Listing to Broaden U.S. Investor Access
Shares of JD Sports in the U.S. now trade on the OTCQX exchange from the Pink Limited Market, broadening its access to deeper capital pools.
EARLY CHILDHOOD EDUCATION ENDOWMENT ADVISORY BOARD APPROVES HEALTH INSURANCE SUBISIDY PROGRAM FOR EARLY CHILDHOOD EDUCATORS
EARLY CHILDHOOD EDUCATION ENDOWMENT ADVISORY BOARD APPROVES HEALTH INSURANCE SUBSIDY PROGRAM FOR EARLY CHILDHOOD EDUCATORS FOR IMMEDIATE RELEASE June 25, 2026 The Early Childhood Education Endowment’s Advisory Board voted on Tuesday to approve the new early childhood educator health insurance subsidy program beginning in 2027 and available through Access Health CT open enrollment starting October 23, 2026. Established into law…
Mars Meets The Seven Sisters, In Astronomical Event You Won't See Again Until 2034
Mars meets the Pleiades this weekend, the subject of what may be humanity's oldest story.
ServiceNow: An Excellent Business Trading at a Discount
ServiceNow is doing everything right, and its stock price should begin to reflect that fact.
Comcast's Sky to Buy ITV's Media and Entertainment Unit for $2.1 Billion
Comcast-owned Sky Group has reportedly agreed to acquire the media and entertainment business unit of U.K.-based ITV for $2.1 billion. The deal is expected to be officially announced in two weeks. Satellite operator Sky will absorb ITV’s broadcast network, linear free-to-air channels, and the ITVX subscription streaming service with 900,000 paid subscribers and 16.4 million … Continue reading "Comcast’s Sky to Buy ITV’s Media and Entertainment Unit for $2.1 Billion"
Psychedelic Science 2027 Speaker Submission Invites the Field to Bridge Promise and Practice
Psychedelic Science 2027 (PS27) convenes May 3–7, 2027, at the Colorado Convention Center in Denver under the theme “Bridging Promise & Practice”PS27’s speaker submission is now open through Friday, September 18, with no planned extensionsPS27 welcomes proposals across science, therapy, policy, culture, industry, the humanities, spirituality, connected movements, and the wisdom traditions that have carried this work for generations DENVER, June 25, 2026 (GLOBE NEWSWIRE) -- The Multidisciplinary
'This is the next jump in technology': World's first sub-1nm chip keeps Moore's Law alive a little longer
IBM's NanoStack architecture has helped scientists cram 100 billion transistors onto a computer chip, delivering 50% better performance and consuming 70% less energy than the current generation.
Paranovus Entertainment Technology Limited Announces 1-For-100 Reverse Share Split
NEW YORK, NY / ACCESS Newswire / June 25, 2026 / Paranovus Entertainment Technology Limited (NASDAQ:PAVS) ("we" or the "Company"), today announced that it will effect a reverse share split of its outstanding Class A ordinary shares, par value $0.000012 ...
KUSTOM ENTERTAINMENT, INC. ANNOUNCES BINDING AGREEMENT FOR THE DIVESTITURE OF ITS VIDEO SOLUTIONS SEGMENT TO FULLY COMPLETE LIVE ENTERTAINMENT PIVOT
Transaction Structured to Provide Up to $5.5 Million plus 2,000,000 Warrants to acquire shares of common stock of Cycurion, Inc.; Follows Previously Announced Major Live Music Expansion Partnership with Gilley’s Park City OVERLAND PARK, KS, June 25, 2026 (GLOBE NEWSWIRE) -- Kustom Entertainment, Inc. (Nasdaq: KUST) (the “Company”), a live entertainment and music festival company, today announced it has entered into a binding agreement for the divestiture of its legacy video solutions division to
Moderna Science Day Highlights Expanding Potential of mRNA Platform
Provides broad overview of Company's research and early development programs expected to continue to fuel future growth Highlights validation of T-cell engager modality with mRNA-2808 in multiple myeloma, supporting rapid advancement of second T-cell ...
AMC Entertainment Holdings, Inc. Announces Closing of $200 Million Registered Direct Offering of Common Stock
LEAWOOD, Kan., June 25, 2026--AMC Entertainment Holdings, Inc. (NYSE: AMC) ("AMC" or "the Company"), announced today that it closed its previously announced registered direct offering of an aggregate of 95,250,000 shares of AMC common stock for gross proceeds of approximately $200 million (the "Offering"), before deducting agent fees and offering expenses.
What are the best businesses in Centre County? Submit your nominations to CBICC
Your input can help recognize a deserving local business or nonprofit organization.
Jeffrey Epstein's friends' settlements draw Congress' interest
Members of Congress have discussed issuing subpoenas to find out about the NDAs between some of Jeffrey Epstein's friends and his accusers.
Louisville doctor, nurse and nonprofit founder charged in federal health care fraud crackdown
Federal prosecutors in the Western District of Kentucky announced charges in four separate cases involving alleged schemes to defraud Medicare and Medicaid, misuse medical credentials and controlled substances, and submit
What Does Success Look Like in 2026 for Dolphins?
The meaning of the word success can be subjective. But for the Miami Dolphins in 2026, the number of wins shouldn't be the measure of success. After moving on from veterans such as Tua Tagovailoa and Tyreek Hill, the upcoming season is about developing the Dolphins' roster, resetting the culture, ...
Michigan health department awards $3.75M in opioid settlement funding for youth substance use prevention
Alex Rodriguez on how to build a business empire and what an MLB strike would mean to baseball
Baseball star Alex Rodriguez started building his business with a single $250,000 investment in 1995.
A-Rod talks his journey through the 'two B's': Baseball & Business
Former MLB All-Star and A-Rod Corp CEO Alex Rodriguez sits down with Yahoo Finance Executive Editor Brian Sozzi at the 2026 Cannes Lions International Festival of Creativity to discuss his upbringing and personal journeys through baseball and his ventures off the field in the world of business.
Pints & Politics with WUNC's Colin Campbell in Pittsboro
To celebrate WUNC's 50th anniversary this year, we're hosting 50 events across North Carolina! Please join us on August 19 at BMC Brewing at The Plant in Pittsboro for Pints & Politics with WUNC Capitol Bureau Chief Colin Campbell! The event kicks off at 6 p.m.We'll chat about all things North Carolina politics, and your first pint will be on BMC Brewing in a special WUNC 50th anniversary pint glass! This event is free and open to the public, but an RSVP is encouraged as space is limited. Please RSVP at the link below to let us know if you are planning to join us. You can also submit a question for Colin in advance when you sign up to attend. We hope to see you soon!> RSVP Here
QED Science Launches AI Infrastructure for Scientific Validation
Recognizes The 1% After Blind Evaluation of 57,455 Scientific PreprintsTEL AVIV, Israel, June 24, 2026 (GLOBE NEWSWIRE) -- QED Science, a science validity engine and modern infrastructure for researchers, funders, institutions and life science organizations today launched The 1%, the top 574 life science preprints. The company anonymously scored 57,455 bioRxiv preprints submitted between May 2025 and April 2026 for originality and validity. The ranking is powered by QED Score, QED Science’s vali
How wearable tech aims to innovate women's health care
Clair Health co-founder and CTO (Chief Technology Officer) Abhinav Agarwal comes on Asking for a Trend to explain how the company is using AI models in its hormone monitoring device and how new doctors, specifically OBGYNs, can use it to learn more.
JioStar Exec Joins 'Subedaar' Studio Abundantia Entertainment
JioStar exec Ramesh Mundhra is leaving the Indian content giant for Subedaar producer Abundantia Entertainment.
Dozens in Florida among hundreds charged in a DOJ crackdown on healthcare fraud
The two-week operation uncovered more than $6.5 billion in false claims submitted to insurers, according to the Department of Justice. Nearly two dozen arrests were made by state authorities.
CEO of FNB Honored for Business Excellence, Leadership
Vincent Delie, chairman, president and CEO of F.N.B. Corp. and its largest subsidiary, First National Bank, received two national awards.
Marine surveys: Science and stewardship in action
Submitted by San Juan County.
German Business Confidence Edges Higher on Hopes Iran Tensions Ease
The Ifo business-climate index nevertheless remains at a subdued level, having plummeted after the outbreak of the war in Iran.
Introducing: Grand Seiko Updates The Core Evolution 9 Collection With Tapered Bracelets And Micro-Adjustment Clasps (Live Pics)
A whopping nine new references with both major and subtle tweaks.
'Rangers close to re-signing McCrorie'
Rangers are closing in on a deal to bring 28-year-old versatile Scotland-capped defender Ross McCrorie back to Ibrox from Bristol City. Rangers Review) Rangers are preparing to submit a formal offer for 22-year-old Dundee centre-back Luke Graham in the coming weeks. Football Insider) Head coach Steven Pressley says Dundee have received "plenty of phone calls" about Luke Graham this summer, but there has been no firm offers for the centre-half who trained with the senior Scotland squad before the World Cup.
Florida Attorney General Issues Subpoena to CVS Health in Pharmacy Probe
Florida’s attorney general says he is examining whether CVS’s pharmacy benefit manager steers patients to its own pharmacies.
AMC Entertainment Holdings (AMC) Is Down 16.5% After Dilutive Debt-Reduction Equity Raise - Has The Bull Case Changed?
Earlier today, AMC Entertainment Holdings announced a registered direct follow-on equity offering of 95,250,000 common shares at about US$2.10 each, aiming to raise roughly US$200.03 million primarily to redeem 6.125% Senior Subordinated Notes due 2027 and for general corporate purposes. This latest capital raise follows AMC’s roughly US$150 million at-the-market equity offering completed in early June, underlining how ongoing balance sheet repair is coming at the cost of further dilution...
Roku May Help Fox Avoid Aggregeddon
(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) Scrolling through links over the last week, I stumbled across this fun headline: Wow. Formula 1 (the sport, not the docu-series) is the perfect “dog not barking”. As a reminder, each week in my Streaming Ratings Report, I call out the shows that miss every viewership chart. I dub them “dogs not barking”—like the Sherlock Holmes mystery—because without any data, we forget they even exist. This is in contrast to something like, say, a film flop—cough The Mandalorian and Grogu cough—where even underperforming at the box office is widely discussed here, there and everywhere. In the US, Formula 1 is now in “no public viewership data, so not discussed” territory. After moving to Apple TV from its former home of ESPN, basically no one talks about it. Apple did publish an initial, unsourced, unsubstantiated, (dare I say unserious) datecdote claiming more folks are watching Formula 1 on Apple than ESPN, but we haven’t gotten any updates since. This stands in contrast to when the sport streamed on ESPN, and ESPN PR provided weekly viewership figures. Formula 1 was, at best, a niche sport in America—averaging 1.3 million viewers in the Big Data Plus era—but now it’s basically anonymous. (And yeah, after moving to Apple, I very, very, very much doubt its ratings increased.) Unfortunately, that story isn’t quite big enough to warrant a section in today’s “Most Important Story of the Week” column, but I wanted to call it out, because otherwise, no one else will! Certainly, no one will write articles about the silence/ratings decline, unlike when they wrote breathless articles connecting the rise in viewership to Netflix’s Drive to Survive, including Reuters just last month. (This is a topic I’ve tried to provide a moderate/nuanced/non-hyped take since 2022.) Anyway, on to this week’s issue. I was a bit worried I didn’t have a juicy topic, then the Murdochs went out and did their Murdoch thing: buying Roku. So that’s the story of the week, and it happens to touch on quite a few themes of the streaming wars and the disruption therein. I’ll cover that, plus why more consolidation in Hollywood media looks likely, more good news on the Hollywood labor front, whether we’ll see an uptick in production in Los Angeles, some Broadway and theme park news, cellphone prices going up in the third world (and possibly everywhere), and more. Subscribe Most Important Story of the Week - Another Big Media & Entertainment Merger The story of the week is clearly Fox is buying Roku for $22 billion. I read a lot of good strategy takes on why Fox bought this streaming TV device maker—and I’ll have mine below—but what fascinates me more is how this deal connects to quite a few themes of the streaming wars, linking to everything from the pace of M&A to “aggregeddon” to Netflix’s recent M&A actions/inactions to the shift to advertising from pure play streaming and more. The only topic I can’t really connect it to is my old theory, “never bet against Rupert Murdoch” because he isn’t the one who did this deal; his son Lachlan inked it. (Do I think he provided advice, even at his 95 years of age? Sure.) That plus I have one additional piece of strategy for all entertainment players, inspired by this deal. So let’s dive into all those topics, starting with why I like this deal. Roku is a Great M&A Buy