SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " read " 9,344 found 🔀 AI-powered Shuffle
The five deep-sea arrays of the Ocean Observatories Initiative had been streaming continuous readings from the Atlantic and Pacific since 2016, and in May 2026 the National Science Foundation said four would be pulled out of the water before reversing course on June 18
The five deep-sea arrays of the Ocean Observatories Initiative streamed continuous readings from the Atlantic and Pacific for a decade. In May 2026 the National Science Foundation moved to pull four of them out. A bipartisan Senate revolt reversed the plan — but the data gap and the deeper funding cliff remain.
Bangladesh fights world's worst measles outbreak as vaccination gaps fuel spread
Bangladesh, which once came close to eliminating measles, is facing its worst outbreak on record, with 999 suspected and confirmed measles-related deaths reported since March as hospitals struggle with overcrowding, shortages and a continuing influx of sick children.
Perea Rejoins FGI Risk as Director of Business Development
FGI Worldwide, a provider of working capital financing and trade credit insurance solutions, readded Rick Perea to FGI Risk as director of business
66-75: Chart
Mariners Pitchers 2023-2024: Lazaro Montes, +0.20Mariners Pitchers The Other Five Years This Decade: Eduard Bazardo -0.31 WPA, Bryce Miller -0.12 WPA, José Ferrer -0.12 Game Thread Comment(s) of the Day
Improv troupe to bring an evening of laughter to Waynesville
Get ready for an evening of spontaneous comedy and nonstop laughter as Waynesville-based Parking Space Comedy Improv performs at 7:30 p.m. Saturday, Sept. 12.
Bridgeport community rallying around business, residents after Labor Day fire
Officials say the fire started in the used car dealership and then spread to a boat and car.
Home-based bread business Golden Grain opens first Worcester café
Golden Grain Artisanal Bread Café, which began in a family kitchen in 2024, is opening its first brick-and-mortar location at 250 Commercial St. in downtown Worcester
49ers former 2nd-rounder suffers devastating injury days before opener
The San Francisco 49ers' already thin defensive line sustained a devastating blow just days before their Week 1 kickoff vs. the Los Angeles Rams.
Hawaiian Telcom Unveils Future-Ready Business Fiber Platform Engineered for 10 Gig Connectivity
Hawaiian Telcom announced enhancements to its business fiber internet portfolio, including expanded symmetrical upload and download speeds across Fioptics Business Internet plans and the introduction of Fioptics Advanced WiFi for business customers. Together, these enhancements provide Hawaiʻi businesses with faster, more scalable connectivity backed by a fiber network engineered to support connectivity solutions up to 10 Gig.
Dan Lanning's Ducks still not ready for college football's primetime
Oregon struggled to find consistency against Boise State to open the season.
Arizona Cardinals Week 1 depth chart vs. Los Angeles Chargers
A look at the Cardinals' first depth chart of the season as they get ready to play the Chargers.
Hurricane Lowell forces bank closures across Kauai, parts of Oahu and Maui
All major Hawaii banks closed Kauai branches Tuesday as Hurricane Lowell brought high winds, heavy rain and widespread power outages to the islands.
Geologists reveal the Americas collided millions of years earlier than thought
Volcanic rocks in Colombia are rewriting the timeline of the collision between Central and South America. Their magnetic signatures show that major tectonic deformation had already weakened by the late Miocene, suggesting the most intense collision occurred earlier than previously believed.
The Nonlinear Science Behind Large Language Models
LLMs are black boxes, but the principles that govern them are not. Read this article for a detailed introduction to chaos and complexity theory applied to LLMs.
Helping Children Unlock the Science of Reading
For children who struggle to read, even a single page can feel like a puzzle everyone else already knows how to solve. Certified reading specialist and author Christie Welsby is helping families na…
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Laika Readies ‘Made by Humans: Creatives in Conversation,’ a New Video/Podcast Series
"Made by Humans: Creatives in Conversation," a new video/podcast series from LAIKA, partners creators in new and unique ways.
Smithfield Foods expects to swing to third-quarter operating loss in fresh pork business
Smithfield Foods said on Tuesday its fresh pork segment is expected to swing to an adjusted operating loss in the third quarter, due to persistent pressure from lower hog prices and a shrinking industry market spread amid cautious spending.
Pritzker-backed PAC plans to bankroll anti-Trump candidates nationwide
The committee, called “Ready for the Fight” in reference to a line from Pritzker campaign speeches, launched today.
3 Takeaways From the Latest PISA Test of Reading, Math, and Science
The results show reading performance dropping across the world—and one uniquely troubling U.S. trend.
Lions star Jahmyr Gibbs gets good news from NFL experts
Detroit Lions' Jahmyr Gibbs is already getting praise.
Scientists engineer ready-to-use cancer-fighting T cells for solid tumors
T-cell receptor, or TCR, therapy is a cancer treatment that genetically reprograms immune cells, called T cells, to hunt down cancer with precision. It's similar to another treatment, CAR T-cell therapy, ...
Survey: Will Michigan cover the spread vs Oklahoma?
Will Michigan cover the spread against Oklahoma? Vote in this edition of SB Nation Reacts.
Richarlison Accepts Vasco Offer but Tottenham Loan Limit Blocks Move
Richarlison has reportedly agreed to join Campeonato Brasileiro Série A side Vasco da Gama, but the move can’t proceed because Tottenham Hotspur have already reached their limit for international loans.
College Football Has Completely Lost Its Mind
College football has been back for one full week . That’s it. And somehow we already have a tweet perfectly summarizing just how ridiculous this season has become. LSU is dealing with a legal fight that has reached the point where SEC leaders could vote on whether to expel the school from the conference. Western…
North Carolina MCO Alliance Health Taps Cortica to Rein in Autism Spending, Improve Outcomes
Ready to dive into what's shaping autism therapy-payer relations? Be a part of the Autism Investor Summit East this November 9–10. Get your tickets here.
Puppy Pals Live Wags Its Way Back to the Niswonger
an Wert, OH [Sept 7, 2026] - Get ready for an afternoon filled with four-legged fun as Puppy Pals Live returns to the Niswonger Performing Arts Center on Sunday, September
Small Gym September: Meet Beyond Cheer Athletics
Beyond Cheer Athletics is presenting New York City strong! Learn more about the program that is already making a name for itself from 2020 to now!
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Arsenal 2-1 Chelsea win changes the transfer-window conversation
Arsenal’s win over Chelsea put the transfer debate into perspective, with the champions showing why their existing squad may already be strong enough.Photo by Ryan Pierse/Getty ImagesI don’t know ...
Israel to mandate Iodine in table salt amid widespread deficiency
Studies have found widespread iodine deficiency in Israel, particularly among pregnant women and children. The condition can cause thyroid problems and, in severe cases, developmental and neurological damage
Doctors Without Borders warns that funding cuts are forcing health clinics to close
Aid groups say three dozen health facilities in Sudan are closing this year due to global aid cuts. This worsens an already dire humanitarian situation in a country torn by more than three years of war.
🚨XIs ready: City visit Porto in their European opener
Estádio do Dragão is getting ready to host an electrifying UEFA Champions League opener. Francesco Farioli’s FC Porto come into it on fire after putting together seven straight wins and opening th...
Dbrand already has iPhone Ultra cases, spoiling Apple's surprise
Dbrand is getting the jump on the worst-kept secret in the smartphone world.
From science to screen time: 4 key takeaways from the latest PISA results
Amid reading declines that included a 14-point drop for the U.S., researchers are looking at the role digital learning and AI may have played.
What Trump’s new study says about support for trans rights — and why experts are worried
This story was originally reported by Orion Rummler and Jasmine Mithani of The 19th. Meet Orion and Jasmine and read more of their reporting on gender, politics and policy. A new study from the Trump administration is sending alarm bells through pro-democracy groups for its potential to fuel a crackdown on Americans who support LGBTQ+ […]
Neither political donations nor special interest groups should dictate policy
Letters: Readers respond to George Monbiot’s article on Andy Burnham and political donations
Newman Regional Health, strategic partners now part of brand-new Astra Health collaborative
Already with external partnerships involving University of Kansas Health System and LMH Health, Newman Regiona...
How to watch the 2026 Emmys: Start time, where to stream, full nominee list and more
Are you ready for the 78th Primetime Emmy Awards?
Business internship presentations connect classroom learning to career readiness
Nineteen Penn State Lehigh Valley business students concluded their required summer internships by presenting what they learned to faculty and staff evaluators. The presentations culminated a semester-long process designed to help students connect their academic preparation, workplace experiences and career-readiness skills.
Sony is reportedly preparing a big update for the PS5 and PS5 Pro with improvements to PSSR 2.0 upscaling
Sony is reportedly getting ready to release a major new system update for the PS5, with firmware version 14.0 currently is beta.
Apple to Introduce All-New 'Readiness' App Tomorrow
Apple plans to announce an all-new "Readiness" app during its "Surprise and Shine" event this Wednesday, according to Bloomberg's Mark Gurman. In a social media post today, Gurman said the "Readiness" app will be a "variant" of the existing Vitals app on the Apple Watch. "The idea is to better compete with software from Whoop and Oura," he said.
Week 1 Reminded Us Why College Football Is the Best
College football is officially back. And somehow, Week 1 already gave us enough storylines for an entire season. The biggest statement came from LSU . Lane Kiffin’s debut couldn’t have gone much better, as No. 11 LSU absolutely destroyed Clemson 51-10 in Death Valley. LSU piled up 644 yards while holding Clemson to just 145.…
2026 Boolermaker Kids Race Registration Opens September 14
Kids can get ready for a spooky day of running and fun at the Boolermaker, which returns to T.R. Proctor Park.
Rebel Wolves Already Working On 'Next Chapter in The Dawnwalker Saga'
Rebel Wolves has revealed it's already working on the next game in the Dawnwalker saga after the success of The Blood of Dawnwalker.
From 'Love Hypothesis' to 'Fourth Wing,' 60 BookTok favorites coming to screens
Hollywood is finally catching up to BookTok. The well-read corner of the internet brought decade-old titles back to bestseller lists and new life to bookish communities.
Global report shows where US kids rank in reading, math and science
ABC News' Elizabeth Schulze has the results of a new report released this morning showing where U.S. students rank compared with students around the world.
What to Chase in 2026 Panini Donruss WNBA
The 2026 WNBA trading card season is officially in full swing, and collectors are already hunting down the most coveted pulls in the new Panini Donruss WNBA set.
The Good, the Bad, the Ugly: Week 1
Through week one, we are already starting to have some clarity as to who the top teams in the Group of Six are. North Dakota State has looked dominant through two games, Boise State almost pulled off a massive upset against a National Championship contender, and the Air Force defense looks improved. It is certainly […]
Louisiana concrete companies join forces to capitalize on construction boom
Two Louisiana concrete suppliers are joining forces with two out-of-state companies to pursue large-scale construction projects as billions of dollars in new industrial and technology investment move … Already an INSIDER? Sign in. Already an INSIDER? Sign in
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Spirit Halloween stores are already open for the fall season. See southeast Louisiana locations.
As the fall season approaches, Spirit Halloween stores are popping up seemingly overnight. Here’s where to find the costume shop this year.
I’ve already picked my National Television Awards winners - here’s who I think will be bringing home the trophies
The competition is fierce, but I know who I want to come away from the ceremony with a gong
DeWitt’s Crossroads Business Park gets ready for growth
DEWITT, Iowa – Community leaders and development partners recently celebrated the groundbreaking of five regional water detention ponds in an expansion of the Crossroads Business Park, marking a major milestone in preparing the site for future industrial growth. The project is the first phase of infrastructure improvements that will make approximately 125 acres of development […]
Straight-Six-Powered BMW M350 Promises 440 HP and a Drift Mode: TDS
Also, Stellantis has expanded an already massive Jeep Grand Cherokee suspension recall, and the new Audi A2 is an EV we'll be sad to miss out on.
‘Plastic pollution hotspots’ spawn a public health crisis across Latin America
Since China banned the import of plastic waste in 2018, plastic pollution has been having a growing impact on the people and ecosystems of Latin America. As the region imports an increasing amount of the world’s used and discarded plastic, new research shows that waste infrastructure in many countries is already buckling under the strain […]
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
Turkish students score above OECD average in science, reading in PISA 2025
Fifteen-year-old students in Turkey scored above the OECD average in science and reading in the latest international assessment, while their mathematics score came within one point of the average, according to results released Tuesday. The OECD’s Programme for International Student Assessment (PISA) 2025 report showed that Turkey earned an average score of 494 in science […]
Assessing Kelp Bed Expansion Around Kodiak Island in Alaska - NCCOS - National Centers for Coastal Ocean Science
Scientists from NOAA’s National Centers for Coastal Ocean Science Kasitsna Bay Laboratory joined a week-long mission to investigate the recent expansion of giant kelp forests in waters surrounding Kodiak Island, Alaska. Bull kelp, the predominant canopy kelp in the region, has been largely replaced by giant kelp in the last couple of decades. While both ... Read more
Robinson's tired excuses don't cut it as pressure mounts
The latest in the line of Stephen Robinson's excuses was that the players were tired from recent travelling. It's time for excuses and talking to stop. Sadly it feels like time is already against Robinson - the fans made their feelings known at full-time on Saturday.
📺 Follow Napoli's UEFA Champions League journey on NOW!
Napoli are back in the Champions League and getting ready for a new European season packed with major challenges. Massimiliano Allegri’s side will face Arsenal, Manchester City, Porto, Villarreal, C...
📺 Follow Roma’s Champions League journey live on NOW!
After seven years away, Roma are back in the Champions League. Gian Piero Gasperini’s Giallorossi are ready to test themselves against some of Europe’s best teams, including Real Madrid, PSG and M...
Taiwan students rank 4th globally in science, 3rd in reading: PISA 2025
Taiwan's 15-year-old students ranked fourth in the world in science and mathematics and achieved a record-high third place in reading literacy in the 2025 Programme for International Student Assessment (PISA), the Ministry of Education and National Taiwan Normal University (NTNU) announced Tuesday.
(BPRW) ProcuraFind® and Ally Financial Announce Strategic Initiative to Advance Small Business Growth Through Education, Readiness, and Opportunity
(Black PR Wire) Charlotte, N.C. — ProcuraFind® and Ally Financial announced a strategic, multi-year agreement focused on helping small businesses build stronger companies through education, financial empowerment, supplie...
NFL power rankings Week 1: Did a Super Bowl 60 teams miss top five?
As the 2026 NFL season kicks off, last year's two best teams already find themselves looking up at this year's apparent challengers.
Polish students outperform EU average in math, reading and science as global scores slide
Polish students outperform the EU average in educational outcomes but remain below pre-pandemic levels.
NC State a 30.5-point favorite against Richmond
It’s about time for NC State to get on with the rest of its season, and thank goodness for that, since having to sit on a terrible performance for two weeks is pretty unpleasant, it turns out. I’m sure the Pack is more than ready to get back on the field. The task will be […]
Range Sports to feature Baylor, USC women in inaugural Hollywood Hardwood Classic on BTN
The event will mark the first women’s college basketball game at the Clippers’ arena in Inglewood, Calif. Will Funk, Range Sports’ co-President, tells SBJ that the company is already looking at other opportunities in the college realm, as NIL has “created more space to create unique matchups,"
Singapore ministers, among world’s highest paid government officials, get first raise in 15 years
KUALA LUMPUR, Malaysa (AP) — Singapore’s ministers, already among the world's highest paid, are getting a raise for the first time in 15 years, Prime Minister L
Video Global report shows where US kids rank in reading, math and science
ABC News' Elizabeth Schulze has the results of a new report released this morning showing where U.S. students rank compared with students around the world.
NI education: Pupils' scores in reading and maths fall over last decade
The Programme for International Student Assessment (Pisa) tests are seen as a significant benchmark in how education systems are performing.
How to watch the 2026 Emmys: Start time, presenters, full nominee list and more
Are you ready for the 78th Primetime Emmy Awards?
Gin Blossoms ready to play the hits in North Liberty
The Gin Blossoms, who will perform Sunday, Sept. 13, at Hy-Vee Amphitheater at Centennial Park in North Liberty, are working on a new album. But they’re aware that most in
'The Pitt' led 2026 Emmy nominations. But another show is ahead after the early awards.
The biggest prizes are still ahead, but shows including "Widow's Bay" and "DTF St. Louis" have already made their mark.
Louisville tech firm V-Soft already seeing payoffs from its latest acquisition
V-Soft's acquisition of St. Paul-based Logisolve adds data and AI capabilities, helping the Louisville firm expand its technology consulting offerings.
Community Health Partners & Prostate Cancer Awareness Month
Community Health Partners of Sioux County is working to spread awareness of prostate cancer awareness month. Community Health Partners is working to inform Siouxland residents about prostate cance…
'Arsenal look top'
"I thought Arsenal were fluid last season, but I feel like they are actually more fluid this season," says former England defender Conor Coady. "Arsenal look the most ready I've seen them in a long time at this stage of a season," Coady told BBC Radio 5 Live's Monday Night Club.
'I'm ready to try and establish myself'
Bournemouth forward Daniel Jebbison says he is "ready" to make an impact whenever he is given the nod by Marco Rose this season. Jebbison has completed two loan spells at Championship outfits Watford and Preston North End in recent seasons and is hopeful those experiences will now help him "establish" himself with the Cherries. "I'm ready and I'm patient," Jebbison said.
Colts' Shane Steichen Gives Alec Pierce Update for Week 1
Indianapolis Colts wide receiver Alec Pierce recently returned to practice following ankle surgery, but will he be ready for this Sunday against the Baltimore Ravens?
In 1942, scientists stacked roughly 45,000 graphite blocks beneath the stands of a Chicago football stadium and started the world’s first nuclear reactor — while one physicist waited nearby with an axe, ready to cut a rope and drop an emergency rod if the reaction ran out of control
The architect of the atomic age had no emergency button, no computer failsafe—just a physicist with an axe and steady nerves standing between Chicago and catastrophe.
Schools shouldn't ban tech. They should teach kids to control it
Kids need screen-time limits and lessons in the logic behind computers.
NFL Expert Makes Bold Prediction for Rams TE Terrance Ferguson
The Los Angeles Rams could have another offensive weapon ready to emerge in 2026, and Terrance Ferguson has received a bold prediction ahead of his second NFL season. The young tight end is being projected to catch eight touchdown passes as the Rams look for another reliable option in their high-powered passing attack. Ferguson showed […] The post NFL Expert Makes Bold Prediction for Rams TE Terrance Ferguson appeared first on Gridiron Heroics.
Will Angie Nixon drag down the entire Florida Democratic ticket?
Some Democrats see her energizing a largely untapped base of new voters, but Republicans are ready to use her as an anchor down ballot.
Canadian teens still rank among the world's best in reading, math and science — but scores are slipping. Here's why
Canada's decline in 2025 mirrors a global downward trend, according to the latest findings from the Organisation for Economic Co-operation and Development.
Pink Chicken's Customers Outgrew Its Kids' Clothes. The Brand Grew With Them, Into an 8-Figure Business
The 20-year-old company expanded from kidswear into baby, teen, and women’s categories by listening to the families already shopping it.
Read the “Nonnegotiable” petition
A coalition of Michigan rabbis and Jewish leaders is launching a petition drive aimed at Dr. Abdul El-Sayed, the Democratic Senate nominee.
Nick Bosa Is Back. The NFL Might Have a Problem.
The NFL season has not even officially started yet, and Nick Bosa is already giving everyone something to talk about. The San Francisco 49ers defensive star is expected to play Thursday against the Los Angeles Rams in Melbourne after missing the 2025 season with a torn ACL. Yes, that ACL. Bosa has already returned to…
Sunburn — The morning read of what’s hot in Florida politics
Start strong with Sunburn, Florida’s essential morning political power briefing.
2,300 Roma fans expected for first Champions League match
The atmosphere in Istanbul will be heated. It won’t be an easy trip for Roma, but Gian Piero Gasperini’s team seems ready to face Fenerbahce among their fans, coming off a 2-1 defeat to Besiktas. ...
Swedish results in maths, reading and science plummet to historic low in new Pisa poll
Swedish pupils have never before been as poor in mathematics, reading comprehension and science in any Pisa survey in 25 years, in shock results that present a stark wake-up call.
Elversberg coach Wagner to miss Bayern clash due to suspension
Elversberg coach Vincent Wagner was handed a one-game suspension after the German Football Federation (DFB) denied the club's appeal. The DFB announced the decision in a statement on Monday evening and said that another appeal has already been filed against the ruling.
Israel records one of OECD’s steepest declines in reading, math and science scores
Israeli 15-year-olds lost 38 points in reading, 25 in math and 23 in science since 2022, leaving the country below the OECD average in every field; nearly 3 in 10 now lack basic proficiency across all three
“HALLOWEEN: THE GAME” BANNED FROM PLAYSTATION IN JAPAN
Although many PlayStation users the world over will be excitedly getting lost in Halloween: The Game this week, that doesn’t include those in Japan. Sadly, hot on the heels of controversy in Australia and New Zealand, we’ve learned that Halloween: The Game has been banned from the PlayStation store in Japan. The news was confirmed ...Read More
UK pupils rank highly again in international reading, maths and science tests
But the Pisa test scores vary significantly between England, Northern Ireland, Scotland and Wales.
UK pupils rank highly in international reading, maths and science tests
But the Pisa test scores vary significantly between England, Northern Ireland, Scotland and Wales.
Israeli students plunge to historic lows in reading, math and science
International PISA results reveal the steepest decline in Israel's history across literacy fields, erasing 15 years of improvement. The troubling implication:
England’s teenagers outperform peers in most countries in maths, reading and science
OECD test sees results dip in almost all member nations and warns of ‘digital distractions’ eroding academic skills
The Lowdown On Bournemouth's EFL Cup Opponents Lincoln City
Lincoln head to Bournemouth hoping a cup upset is on the cards. The Imps have made a decent start to life in the Championship following promotion, while its anticipated the Cherries will be much changed for this one, so Bournemouth may need to tread carefully in this one.