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Vanderbilt Lung Transplant Program sets new record
The Vanderbilt Transplant Center is now the second largest lung transplant center in the United States by volume, with 149 lung transplants in 2025, the most ever in one year at Vanderbilt Health. The Vanderbilt Lung Transplant Program leads the nation in organ preservation and regeneration and is among the best in long-term outcomes, demonstrating the success of the interdisciplinary team in caring for these complex patients. Several features make the program unique in the United States, said Konrad Hoetzenecker, MD, PhD, professor of Thoracic Surgery and surgical director of the Vanderbilt Lung Transplant Program. Vanderbilt serves as a “second opinion center” and accepts most complex candidates that are turned down by other centers due to increased perioperative risk. This includes patients over 70 years old, patients requiring combined procedures with their transplant, multiorgan transplantations and sensitized patients (individuals who have pre-formed anti-HLA antibodies who are at higher risk for complications). The expertise and excellent outcomes have attracted patients far beyond the borders of Tennessee; almost half of Vanderbilt Health’s lung transplant recipients come from out of state. “Another unique feature is our minimally invasive transplant program,” Hoetzenecker said. “By using distinct surgical instruments and techniques, the incisions can be kept as small as 7 to 8 centimeters, which results in better healing, less pain and faster recovery. “This minimally invasive approach is embedded in an Enhanced Recovery After Surgery (ERAS) protocol, a multimodal, evidence-based perioperative care pathway designed to reduce surgical stress, minimize complications and speed up recovery. Our unique ERAS protocol, by a dedicated interdisciplinary approach, aims to improve recovery after lung transplant and reduce ICU and hospital stay.” The lung transplant program recently celebrated a milestone — 1,000 lung transplants since the program began in 1990. “This significant achievement reflects the concerted effort of a multidisciplinary collaboration by the Departments of Thoracic Surgery, Medicine, Anesthesiology and Critical Care,” said David Erasmus, MD, associate professor of Medicine and medical director of Vanderbilt Lung Transplant. Lung transplants have been attempted since the 1960s, but they were largely unsuccessful until the 1980s, when surgical techniques were refined and new antirejection drugs proved effective. Patient outcomes steadily improved from the 1990s to the present. Vanderbilt’s fourth lung transplant recipient in 1990, Pam Everett, is the longest-living, single-lung transplant known in the world, recently celebrating 35 years since her transplant. The Vanderbilt Lung Transplant surgical team is led by Hoetzenecker and Caitlin Demarest, MD, PhD, the surgical director and associate surgical director of the Vanderbilt Lung Transplant program. Erasmus is the medical director of Vanderbilt Lung Transplant along with Anil Trindade, MD, associate medical director and associate professor of Medicine.
FC Barcelona joins Miami business boom, leaves NYC behind for Florida’s business-friendly climate
Miami's One Biscayne Tower lands FC Barcelona as a new office tenant, with CP Group's Angelo Bianco saying the city offers a "liberating" business environment.
/C O R R E C T I O N -- Alliance for Creativity and Entertainment (ACE)/
The Alliance for Creativity and Entertainment (ACE), the world's leading anti‑piracy coalition, has successfully shut down AnimePlay, one of the largest illicit anime streaming applications operating in the Asia-Pacific region. The application was run out of Riau, Indonesia.
Three charts that are warning signs flashing for Trump on Iran war
As gas prices rise, Trump's approval rating is heading into politically dangerous territory.
Apple Plans to Open Up Siri to Rival AI Assistants in iOS 27 Update
(Bloomberg) -- Apple Inc. plans to open Siri to outside artificial intelligence assistants, a major move aimed at bolstering the iPhone as an AI platform.The company is preparing to make the change as part of a Siri overhaul in its upcoming iOS 27 operating system update, according to people with knowledge of the matter. The assistant can already tap into ChatGPT through a partnership with OpenAI, but Apple will now allow competing services to do the same.The changes are part of an attempt to tu
Duraisamy: Supercomputing in service of science and society
Across every frontier of science, engineering and medicine, the convergence of computational science, high-performance computing and artificial intelligence is not merely accelerating research; it is transforming what questions we can ask, what problems we can solve and how quickly solutions can reach the people who need it most. This transformation rests on a foundation that…
Frame Art & Design celebrates 30 years of business
Frame Art & Design is celebrating more than 30 years of expert framing and fine art services.
Five MLB Stadiums Served by Aramark Sports + Entertainment Named to USA TODAY 10Best List for Best Baseball Stadium Food
Aramark Sports + Entertainment is celebrating a standout performance in the USA TODAY 10Best Readers’ Choice Awards for Best Baseball Stadium Food, with five of its MLB partner ballparks ranking among the top 10 in the nation. Citi Field once again led the list, earning recognition as America’s Best Ballpark Food for the fourth consecutive year through fan voting.
Five MLB Stadiums Served by Aramark Sports + Entertainment Named to USA TODAY 10Best List for Best Baseball Stadium Food
Aramark Sports + Entertainment is celebrating a standout performance in the USA TODAY 10Best Readers’ Choice Awards for Best Baseball Stadium Food, with five of its MLB partner ballparks ranking among the top 10 in the nation. Citi Field once again led the list, earning recognition as America’s Best Ballpark Food for the fourth consecutive year through fan voting.
Maine mental health agency targeted in Russian ransomware attack
AMHC is the largest behavioral healthcare provider for a large swath of rural Maine, operating in Aroostook, Hancock and Washington counties.
Department of Public Health Sciences celebrates 10th anniversary of undergraduate public health certificate program
The Clemson University Department of Public Health Sciences is celebrating the 10th anniversary of its undergraduate public health certificate program
Fox News Poll: Voters oppose action in Iran but give US military positive marks
A new poll finds 58% of voters oppose U.S. military action in Iran, while Trump's disapproval rating hits a second-term high of 59%, the survey shows.
READY, SET, IMPLEMENT! Lifelines in Crisis: Prioritizing Women’s, Children’s, and Adolescents’ Health in Humanitarian, Conflict and Climate-affected Settings
This dialogue is part of PMNCH’s Ready, Set, Influence series, bringing together policymakers, humanitarian leaders, donors, and grassroots experts. The webinar will focus on accelerating the implementation of health commitments within humanitarian affairs, specifically focusing on the need for integrated, rights-based health services that remain resilient in the face of conflict, disaster and climate events.
Sonic Frontiers Definitive Edition rated in Korea
The Game Rating and Administration Committee of Korea has rated the unannounced Sonic Frontiers Definitive Edition.
Sphere Entertainment (SPHR) Stock Trades Up, Here Is Why
Shares of content production and distribution company Sphere Entertainment (NYSE:SPHR) jumped 3.1% in the afternoon session after positive analyst sentiment and a rating upgrade from an investment analysis firm fueled investor optimism.
Trump sinks to record low approval rating due to Iran war in new poll
President Donald Trump's approval rating dropped to 36%, its lowest level since his return to the White House, according to a new Reuters/Ipsos poll.
Accelerating Innovative and Effective Pediatric Health Care Delivery Systems: Interventions and Value-Based Care Models for Children with Chronic Health Conditions and Complex Social Needs
Children, youth, and families have unique health needs, which set the foundation for health across the life course; chronic conditions now affect nearly one in three U.S. children, with disproportionate prevalence in those enrolled in Medicaid and CHIP.
Santa Cruz County business filings: Week of March 24
Businesses operating in Santa Cruz County must register with the county clerk. Lookout Santa Cruz reviews the public filings from local businesses to report on new businesses starting in the area.
Marathon has sold 1.2M copies across Steam, PS5, and Xbox
Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
Analysts' new AI stock rating system reveals these winners and losers
William Blair analysts revamped how they are rating AI stocks. In their new framework, seven stocks emerged as winners, while four were downgraded.
Losses triple for Highmark Health in 2025: ‘We’re still in the middle of the storm’
Despite revenue gains, operating losses continued for the second consecutive year in 2025 at hospital and health insurance giant Highmark Health as the...
Why beloved gas station Buc-ee's got an F from Better Business Bureau
The first-ever Buc-ee's location is opening in Arizona, and the travel center just got an F rating from the Better Business Bureau. Here's why.
Notre Dame, NBC Sports panel reflects on 20 years of ‘What Would You Fight For?’ storytelling
On Thursday (March 19), the University of Notre Dame hosted an event celebrating 20 years of storytelling through the “What Would You Fight For?” (WWYFF) campaign. Part of the 2025-26 Notre Dame Forum, the panel discussion brought together leaders from the University and NBC Sports to reflect on the impact and evolution of this storytelling platform.
Beyond The Hype: How AI Is Rewiring Fashion’s Art And Science
AI is recalibrating fashion from design to supply chain. Explore how leaders at Levi’s, ALO Yoga, and REVOLVE bridge data-driven precision with human-inspired creativity.
Microsoft Plans Better Windows 11 RAM Management and a Smoother User Experience
Microsoft recently announced a plethora of changes coming to Windows 11 to reshape the operating system into a completely stable and enjoyable experience. Today we learn that Microsoft plans a major background usage overhaul with future updates, focusing on RAM usage and overall memory management, s...
BUSINESS MONDAY: Spotlight on Sarah's Cheesecakes & Cafe in Pittsfield
The small family-owned and -operated operation is celebrating its 20th anniversary—and looking forward to many more years to come.
Scientists Trap Light in a Layer 1,000x Thinner Than a Hair
Scientists have found a way to trap light in an extremely thin layer, potentially reshaping how future photonic devices are built.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Bash: Trump celebrating Mueller’s death ‘not a surprise, but that doesn’t make it okay’
Urgent Apple warning: Update your iPhone, iPad now
Roughly 25% of all iPhones are operating a version of iOS 18.
Core operating profit rises 4% as net profit holds steady, with full-year dividend maintained at HK35 cents
March 22, 2026 -- The Hong Kong and China Gas Company Limited (stock code: 0003, hereinafter referred to as “the Group”) has announced its 2025 ...
Prior authorization can delay needed health care. A new 'Gold Card' targets that bottleneck.
Getting approval for a medical procedure scan or medicine has become a frustrating hurdle in health care as insurers try to ensure that every test is appropriate...
Health insurance jargon can be frustrating and confusing – here’s how to navigate it
What plan you pick has a huge impact on what you will end up paying.
Why Buc-Ee's Received An 'F' Rating From Better Business Bureau
Buc-ee's is a beloved Texas-based gas/convenience store chain with dozens of locations across the U.S. So why did it get an F from the Better Business Bureau?
Health system operating in full emergency mode following Iranian missile impacts in south
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'A pediatric clinic, but so much more.' Shipley Health Clinic celebrates 55 years
The Margaret B. Shipley Child Health Clinic in Canton is celebrating its 55th anniversary this year.
Why Tencent Music Entertainment Plunged Almost 30% This Week
The Chinese music streaming leader posted decelerating subscription revenue and said it would no longer disclose certain metrics going forward.
Another Planet Entertainment Producing Free Show Celebrating 30 Years of OM Records
Longtime dance label OM Records is celebrating its 30th anniversary with a free concert produced by Another Planet Entertainment.
Letai: “From this point forward, it really is much more like business as usual at the NCI.”
NCI Director Anthony Letai appeared before the National Cancer Advisory Board Committee March 17 to maneuver through thorny topics while reiterating his message of reassurance: Stability. Stability. Stability. NCI is sturdy and will weather the storms. “The mission hasn’t changed at the National Cancer Institute,” Letai said in his remarks to the committee. “The resources […]
Healthcare employee health plan bridges the gap between data and action
Integrating UpToDate evidence-based clinical decision support helps health plan optimize costs and member-centered care.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Douglas County Health Department clears Holiday Inn to reopen water park
The Douglas County Health Department is issuing a public warning about the downtown Holiday Inn on Cuming Street, saying the hotel’s water park is operating without valid permits.
NVIDIA DLSS 5 Gets 84% Dislikes on YouTube as Backlash Grows
NVIDIA's latest DLSS 5 technology has faced a significant community backlash, with its approval rating dropping considerably. On the published YouTube video, NVIDIA's official DLSS 5 announcement has received an overwhelming 83.7% dislikes, with only 16.3% likes. This is a substantial negative ratin...
Trump started a war with no clear end in sight. They rarely end well for presidents
President Trump started a war with no clear end in sight. If his predecessors' experiences are an indication, conflicts don't bode well for presidential approval ratings.
Integrating health equity into energy transitions and climate governance
Nature Medicine - The health benefits of clean energy transitions are unevenly distributed, even when emissions targets are met. A health-centered global governance framework is urgently needed to...
25 Years of Courage and Curiosity: Sally Ride Science at UC San Diego Division of Extended Studies
Celebrating 25 years, Sally Ride Science at UC San Diego inspires students, educators, and families with hands-on STEAM programs that spark curiosity and confidence.
Goldman Sachs says small businesses are embracing AI, but fewer than 1 in 5 are good at actually integrating it
Most small firms embrace AI, but few know how it can help their business.
Georgiana mayor proclaims SBDC day highlighting the center's impact on business growth in Butler County
The City of Georgiana joined communities across the nation in celebrating National SBDC Day on March 18, as Mayor Ninna Bonner issued a proclamation recognizing the impact of the Small Business Development Center (SBDC) at Troy University in supporting entrepreneurs and strengthening economic development across Butler County.
Researchers uncover iPhone spyware capable of penetrating millions of devices
A powerful software exploit capable of penetrating and stealing information from potentially hundreds of millions of Apple iPhones was planted on dozens of websites in Ukraine in recent weeks, researchers said on Wednesday.
I had to jump in and celebrate with fans
Ryley Towler thought only of celebrating with Lincoln City fans in the stands when he scored the equaliser at Huddersfield.
Survey Findings: Integrating Sexual and Reproductive Health into UHC Requires Leadership, Financing, and Political Will
SRHR remains critically underfunded, leaving 164M women with unmet needs and driving preventable maternal deaths. Global survey findings show political commitment is the key driver of financing and integration into UHC. While fiscal constraints persist, leadership determines whether resources are prioritized, enabling equitable access and strengthening health systems.
Women of Science event brings free, family-friendly celebration to New York State Museum
A free, family-friendly event celebrating women scientists is coming to the New York State Museum on March 21, 2026.
Joaquin Garcia: How weight gain became best FBI undercover disguise
Joaquin Garcia, a former FBI agent, gained 90 pounds while infiltrating the mafia. "The fatter I got, the better an undercover agent I became."
Exploding Pintos, imploding politics: Celebrating 50 years of fearless journalism
The Center for Investigative Reporting’s CEO, Monika Bauerlein, looks back on a half-century of “Mother Jones” magazine and what lies ahead for America’s nonprofit newsrooms.
Madison County considers rezoning along scenic byway near Marshall
Lonesome Mountain Market owner Johnny Moore purchased the building in 2022 with the purpose of operating a general/convenience store, he said.
VT Markets and Newcastle United Clinch Double Wins at Forex Sports Awards 2026
VT Markets, a leading global multi-asset broker, has been honoured with the prestigious "Best Global Football Sponsor - Newcastle United F.C" and "Best Commercial Spot - Together, Into Tomorrow" awards at the Forex Sports Awards 2026. The double accolades recognises the brand's high-impact partnership with Newcastle United, celebrating excellence in global brand alignment and fan engagement.
Cash Crunch Drives Nigerian Power Producers Out of Business
A number of heavily indebted Nigerian power producers have ceased operating because their customers aren’t settling their bills and they can’t afford to run their equipment or pay for gas supplies.
Oscar ratings fall 9% in Conan O’Brien’s second year hosting
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A look at how St. Patrick’s Day has evolved in the City of Utica.
Irish dancers bring St. Patrick’s Day celebrations to Lancaster venues [photos]
Irish dancers from the Doherty Petri School of Irish Dance (formerly known as the Paloma School of Irish Dance) could be found celebrating St. Patrick's Day at several bars and
A meteor exploded over Ohio and Pennsylvania
A very loud bang accompanied the disintegrating space rock.
Arizona Charges Kalshi With Operating Illegal Gambling Business
Arizona said it filed criminal charges against Kalshi for operating an illegal gambling business in the state.
Kalshi charged criminally in Arizona for operating illegal gambling business
Arizona's attorney general on Tuesday filed criminal charges against Kalshi, accusing the prediction markets platform of operating an illegal gambling business in the state and unlawfully allowing people to place bets on elections.
Washington Spirit Named Finalist for Sports Business Journal’s 2026 Sports Team of the Year
Washington, D.C. (03/17/2025) – The Washington Spirit has been named one of seven finalists for Sports Business Journal’s 2026 Sports Team of the Year Award, marking the first time the organization has been a nominee for the illustrious annual award. Sports Team of the Year honors a best-in-class organization that demonstrates excellence, influence, innovation and creativity in the business practices of operating a sports franchise across all […]
Washington Spirit Named Finalist for Sports Business Journal’s 2026 Sports Team of the Year
Washington, D.C. (03/17/2025) – The Washington Spirit has been named one of seven finalists for Sports Business Journal’s 2026 Sports Team of the Year Award, marking the first time the organization has been a nominee for the illustrious annual award. Sports Team of the Year honors a best-in-class organization that demonstrates excellence, influence, innovation and creativity in the business practices of operating a sports franchise across all […]
Celebrating Ten Seasons of Entertainment: Thanks to our Sponsors!
This year, the City of Mentor celebrates the tenth season of entertainment at the Mentor Civic Amphitheater. When the facility opened on July 4, 2017, the city made the commitment of providing performances that members of our community might not otherwise
Alibaba shakeup hints at an AI business model
The $325 bln group is separating its AI initiatives from its cloud computing unit. It’s a nod to a craze for digital agents like OpenClaw and willingness of consumers to pay for these standalone services. Monetising AI will remain daunting but the rejig makes sense.
Pair accused of operating fake contracting businesses in Lower Merion Township
Police in Lower Merion Township are looking to identify further victims of an organized fraud scheme involving fake contracting businesses.
University of Florida Penalizes GOP Group Over Antisemitism Accusations
After the University of Florida restricted the Republican organization from operating on campus, the group sued the university arguing its First Amendment rights were violated.
Volvo Construction Equipment announces closure of Rokbak business
As part of a long term strategic shift and due to the unsustainable profitability of the Rokbak business Volvo Construction Equipment (Volvo CE) will close its Rokbak business and concentrate resources on its portfolio of other hauling solutions. The business had revenues of SEK 1.0 bn in 2025 and was loss-making. The closure of the business will negatively impact operating income by about SEK 0.7 billion in the Construction Equipment segment in Q1 2026 and will be reported as an adjustment. About SEK 0.4 billion refers to non-cash items with the majority related to goodwill impairment.
Regional Science Day Hosted at UToledo
Students from schools from 8 counties filled the UToledo student union with research projects and science displays. Students who received top ratings advanced to the state competition.
Buc-ee’s gets F rating from Better Business Bureau. Here’s why
The giant Texas convenience store, known for its brisket, beaver nugget snacks and clean gas station bathrooms, recently received an “F” rating at many of its...
Men’s Health 2026 Grooming Awards: Shave Kit, Hair Serum, More
Men’s Health editorial director Richard Dorment joins TODAY to share some of the winners from the 2026 Grooming Awards. Products include hydrating pillow pads, mouthwash packets and more!
The Top Voices Launches Tech Impact Awards for Small and Medium Businesses Operating in the European B2B Market
LONDON, March 16, 2026 (GLOBE NEWSWIRE) -- The Top Voices Media announced the launch of the Tech Impact Awards for Business 2026, a new edition...
Driving habits of teens and young adults
Nearly all parents think their teen or young adult child’s driving ability is as good or better than other teens and young adults. 1 in 3 parents worry their teen or young adult driver will cause an accident. 1 in 4 parents have taken steps to address their teen or young adult child’s driving behavior. Witnessing risky driving behavior does not affect parents’ rating of their teen or young adult child’s driving ability.
Strengthening One Health Field Epidemiology Capacity in the WHO South-East Asia Region
Recent public health emergencies—including the COVID-19 pandemic, recurrent zoonotic disease outbreaks, and the high level of antimicrobial resistance—have underscored the urgent need for strong, multisectoral field epidemiology capacities. This reinforces the importance of a workforce equipped with One Health field epidemiology competencies. To address this need, WHO works with the Food and Agriculture Organization of the United Nations (FAO), the United Nations Environment Programme (UNEP), and the World Organisation for Animal Health (WOAH), as part of Quadripartite Alliance for One Health, to strengthen field epidemiology training programmes using a One Health approach.These efforts are aligned with WHO SEARO’s Strategic Framework for Action for Strengthening Surveillance, Risk Assessment and Field Epidemiology and the Regional Roadmap to Advance Field Epidemiology Capacities 2025–2029 emphasize workforce development, multisectoral collaboration, and enhanced preparedness for health emergencies. With funding from the Pandemic Fund, The Competency for One Health Field Epidemiology (COHFE) integration within Field Epidemiology Training Programmes (FETPs) or similar initiatives has been initiated in Bangladesh and India and is planned in Sri Lanka.BangladeshIn Bangladesh, COHFE is being adapted to strengthen the Field Epidemiology Training Programme, Bangladesh (FETP-B) Advanced programme. Initiated in July 2025 and led by the Institute of Epidemiology, Disease Control and Research (IEDCR), the process brought together stakeholders from human, animal, and environmental health sectors, academia, and laboratories.A Multisectoral Working Group (MWG) was established to guide implementation, conduct readiness assessments, and identify opportunities to institutionalize One Health collaboration. Through national multisectoral consultations and a competency prioritization workshop held in Dhaka in November 2025, stakeholders identified priority technical competencies for surveillance, outbreak investigation, data analysis, and risk assessment, alongside functional competencies related to leadership, coordination, and the laboratory–epidemiology interface. The process also surfaced systemic barriers—such as challenges in data sharing and limited joint investigations—enabling targeted recommendations. These outcomes are guiding curriculum revision, the introduction of One Health simulations and joint field exercises, and the development of a national multisectoral mentorship pool, with updated training materials expected to be implemented in the upcoming cohort.Figure 1. Competency prioritization involving multisectoral stakeholders“COHFE represents a significant step forward in operationalizing the One Health approach. The collaboration between national institutions and the Quadripartite partners is critical for building resilient systems to address complex health challenges in the region.”, Prof. (Dr) Tahmina Sirin, Director, Institute of Epidemiology, Disease Control and Research (IEDCR), Bangladesh.Aligning India’s One Health Training with COHFEIn India, the National Centre for Disease Control (NCDC) has strengthened One Health workforce development through its SectorConnect initiative. WHO supported a comprehensive competency mapping and curriculum review to align the Field Epidemiology Programme in One Health (FEP-OH) with all 14 COHFE domains. The review identified strong foundations while generating actionable recommendations to strengthen One Health learning outcomes, expand joint field-based learning, and enhance competency-based assessment. These improvements are informing programme refinement and phased scale-up across additional states.Figure 2. Strengthening learning outcomes for the SectorConnect FEP OH CurriculumThrough these efforts, WHO SEARO will continue to support countries to move from separate sector-based training toward an integrated, impact-driven One Health field epidemiology workforce capable of addressing complex health threats at human-animal-environment interface.ReferencesFood and Agriculture Organization of the United Nations, World Health Organization, & World Organisation for Animal Health. (2024). Competencies for One Health field epidemiology (COHFE) framework. https://www.who.int/publications/i/item/9789240080058World Health Organization. (2023). Strategic framework for action for strengthening surveillance, risk assessment and field epidemiology for health security threats in the WHO South-East Asia Region. WHO Regional Office for South-East Asia. https://www.who.int/publications/i/item/9789290210030World Health Organization. (2024). Regional roadmap to advance field epidemiology capacities in the WHO South-East Asia Region 2025–2029. WHO Regional Office for South-East Asia. https://www.who.int/publications/i/item/9789290229544
Integrating brain workouts into health care could save billions in dementia care
The growing research on brain health is a good reminder that while our phones might offer a quick dopamine hit, real engagement offers a much bigger reward.
iOS 27 likely won't include any major changes to Liquid Glass: report
In just a few months, Apple is expected to unveil its latest round of operating systems: iOS 27, macOS 27,...
Buc-ee's F rating, USAA executive pay topped week's news
The beaver-blazoning business received an F rating from the Better Business Bureau, and we learned USAA executives' compensation.
Family-owned real estate firm made Detroit investments at key moments
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Opinion | The Political Cost of Trump’s War
The Republican pollster Kristen Soltis Anderson joins E.J. Dionne Jr. and Robert Siegel to discuss Trump’s falling approval rating and what it portends for November.
Video: Opinion | The Political Cost of Trump’s War
The Republican pollster Kristen Soltis Anderson joins E.J. Dionne Jr. and Robert Siegel to discuss Trump’s falling approval rating and what it portends for November.
Music legend has 24-hour nurse as health battle continues: ‘Frustrating last few years’
He said last year that he is 'very sick.'
Apple to Host 50th Anniversary Celebrations Around the World
Apple today announced that it will be celebrating its upcoming 50th anniversary by hosting gatherings "around the world" throughout the month of March. "Each gathering highlights human creativity and ingenuity in action, and showcases the remarkable things people can do when they have the right Apple products in their hands," said Apple.
UofL to permanently close Rauch Planetarium and Gheens Science Hall, citing cost to reopen
UofL President Gerry Bradley said the planetarium has been operating at a loss for several years and the university subsidized its operation each year.
Maine’s wild blueberries deliver more than tradition. Research proves they support health.
Wild blueberries — the iconic Maine crop dotting hillsides, decorating sweatshirts and adding personality to local menus — is more than a cultural symbol. Over 20 years of preclinical and clinical studies suggest that regularly consuming wild blueberries supports gut and heart health and may reduce risk factors associated with…
Mayor Mamdani says rating agency downgrade is 'premature'
Mamdani expressed confidence Albany will come to the city’s fiscal rescue.
Apple hosts 50th anniversary celebrations around the world
Apple kicked off celebrations in New York for its 50th anniversary and will continue commemorating the milestone throughout the month.
This Healthcare REIT Just Faced a $15 Million Investor Exit Amid Lackluster Stock Returns
This healthcare REIT owns and leases medical facilities nationwide, generating income from long-term net leases with leading tenants.
Scientists Warn: Earthquakes Are Migrating Toward Istanbul Along the Marmara Fault
Researchers analyzing two decades of seismic data have uncovered a striking eastward migration of earthquakes along the Main Marmara Fault.
Vaxart Provides Business Update and Reports Full Year 2025 Financial Results
Topline data from 400-person sentinel cohort of the Phase 2b COVID-19 trial anticipated early Q2 2026 Published positive clinical results in the first quarter of 2026 demonstrating oral norovirus vaccine candidate was safe and immunogenic in lactating women and resulted in passive transfer of antibodies to their infants via breast milk Cash, cash equivalents and investments of $63.8 million as of December 31, 2025; Runway into second quarter of 2027 Conference call today at 4:30 p.m. ET Live sto
As Buc-ee's readies first Ohio store, 38 get 'F' rating from BBB
As Buc-ee's gets ready to open its first store in Ohio, locations in five states received an \
33 Buc-ee’s locations receive ‘F’ rating from Better Business Bureau
Nearly three dozen Buc-ee's locations have received an "F" rating from the Better Business Bureau.
Chain favorite replacing Wawa at Trexler Business Center in Lower Macungie
Qdoba Mexican Eats is launching its third location in the Lehigh Valley, operating by the same group running the Whitehall and Westgate Mall sites.
Tim Cook kicks off Apple's 50th anniversary celebration
Apple rarely looks back, but fifty years since its founding is a milestone not to be missed and CEO Tim Cook has begun by publishing a letter celebrating it.
Liza Minnelli Turns 80: Celebrating An Entertainment Icon
Today, we celebrate the legendary Liza Minnelli on her 80th birthday!
Buc-ee's scores 'F' grade on BBB. Here's why
Stores in Alabama, Georgia, Kentucky, Tennessee and Texas received the low-grade rating.
Sports bar along New Bern Avenue in Raleigh loses permits after multiple shootings
The North Carolina ABC Commission has officially suspended the operating permits for Touchdown Sports Bar in Raleigh following a series of violent incidents over the past year or so.
Apple to celebrate 50 years of thinking different
Apple today announced it will mark its 50th anniversary, celebrating five decades of thinking different and the innovations that helped shape the world.