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Scientists discover new enzyme that could supercharge weight-loss drugs
Researchers at the University of Utah have discovered an enzyme called Pap B that will chemically change and update drugs like Ozempic and Wegovy making them stronger and last longer.
A’s Drop Series Opener To Guardians 8-5
May has officially begun, and the A’s begin the month with a series-opening loss to the Cleveland Guardians, falling to their AL Central foes in a high-scoring 8-5 contest. The starting pitching wasn’t great, the bullpen allowed three runners to cross home plate, and while the offense provided five runs they left 10 on base […]
Mariners' Brendan Donovan set for Double-A rehab assignment
Seattle Mariners third baseman Brendan Donovan will begin a rehab assignment with Double-A Arkansas on Monday, general manager Justin Hollander said. Donovan left Seattle's 5-0 loss to the Texas Rangers on April 17 with a left hip issue, and then was placed on the 10-day injured list three days later with a left groin muscle strain.
Sports media race-baiters are already taking Nikola Jokic criticism too far
Nikola Jokic deserves some criticism after Denver's playoff loss, but the gloating and forced LeBron comparisons reveal more about sports media.
Pressure mounts for Sabres as closeout time arrives as series shifts to Boston
Through two games in Boston at TD Garden, the Bruins have been outscored 9-2 in their home losses in Games 3 and 4.
‘I crumbled’: Former Md. lobbyist launches podcast aimed at young adults navigating job loss, mental health
Juwan Blocker, a Prince George’s County native and former Maryland political aide, reflects on career loss, identity and purpose as he launches a new podcast for young professionals navigating uncertainty.
PwC will drop cover for weight-loss drugs from employee health plans
Big Four accountancy balks at high cost of medication it says has become ‘cultural phenomenon’
UT’s G10 garage could be demolished this summer if Neyland Entertainment District gets final approval
For longtime tailgaters, the potential loss of G10 represents more than just a parking disruption.
Caroline Kennedy makes rare public appearance months after daughter Tatiana's death, 'Love Story' portrayal
Caroline Kennedy made a rare public appearance at a reception honoring King Charles III and Queen Camilla's state visit in New York on Wednesday. The outing came months after the death of her daughter Tatiana Schlossberg, and her depiction on the FX series 'Love Story.'
Baptist Health to lay off 150 at Fort Smith campus amid restructuring
Baptist Health is laying off 150 employees at its Fort Smith campus as they undergo a strategic restructuring to cope with financial loss.
The hills of Samaria: The northern West Bank between politics and daily life
Reporter's Notebook: The hills of Samaria: The northern West Bank between politics and daily life
The Politics Hour: How federal worker cuts are changing the region
Metropolitan Washington Council of Governments' Clark Mercer on the wide-ranging impact of federal job losses and Ward 5 D.C. Councilmember Zachary Parker talks youth jails, curfews, and the city's upcoming elections.
Pittsburgh's Mind-Boggling Playoff Drought Continues With Penguins' Crushing Loss
The Penguins were unable to end Pittsburgh's brutal postseason famine.
LIV Golf announces new strategic intents to continue operations after Saudi funding loss
LIV Golf is searching for new strategies after the loss of Saudi funding.
MU Health Care and Saving Sight are raising awareness for donate a life month
A nonprofit that helps people with vision loss regain their eyesight is encouraging people to register as a donor for Donate A Life Month.
Sony clarifies recent PlayStation DRM update
PlayStation fans and gaming preservations have been alarmed since late last week that a new 30-day timer attached attached to newly-purchased digital games for PlayStation 4 and 5 might render those games unplayable if the system they’re on is offline for longer than a month. But a rep from Sony told Game File today that new system will require only a single online check before it functions as a perpetual license for the digitally purchased game. That is consistent with a newer theory that emerged by gamers testing the 30-day timer over the last two days. “Players can continue to access and play their purchased games as usual,” a rep for PlayStation told me over email. “A one-time online check is required after purchase to confirm the game’s license, after which no further check-ins are needed.” The rep’s explanation squares with the current understanding among players about what’s happening. A multi-day mystery A post last Friday by YouTuber Lance MacDonald spread awareness over the 30-day timer. Quickly, players began stress-testing the system, removing a battery within their PlayStations and checking what would happen if their systems were offline past the timer window. They noticed that setting a PS4 or PS5 to be the “primary” console—a common Sony-authorized method to retain rights to a digital game—wasn’t overriding the 30-day limit. On Tuesday came the breakthrough: A gamer called Andshrew on the Resetera forums posted the results of some tasting. They found that digital games purchased on PS4/PS5 after some time in mid-April would get a 30-day timer that could then be removed and replaced with a perpetual license that would allow the game to be played offline. The transition to the perpetual license occurred some number of days after the digital game was purchased and the system was connected to the internet. They believed that a PlayStation’s online check-in would trigger the license change no sooner than 15 days after the user had purchased the game. This synced with the theory that Sony’s new system is related to the 14-day window that PlayStation users have to request a refund for digitally purchased games. The new timer/check-in system could be a way to defeat some exploit in that refund system, some users theorized. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe In a follow-up, I asked the Sony rep if the 15-day timeline is accurate or if the perpetual license can be activated sooner after purchase. If they share more, I’ll update this post. Sony has not said why they’ve introduced the timer and whether it is designed to stop people from exploiting the refund system. But their explanation suggests that this new DRM method should not result in long-term loss of access to digitally purchased games, just because a PlayStation is offline for a month or Sony’s servers are down. Xbox flashback For many some gamers, the initial reporting of the 30-day timer conjured memories of Microsoft’s disastrous May 2013 announcement of the Xbox One, which was going to require an internet-connected check-in once a day, lest your games become unplayable.1 After widespread backlash, Microsoft abandoned that plan, ahead of the Xbox One’s launch. 1 Fun fact: That 24-hour check-in detail was my scoop from an interview I had that day with then-Xbox exec Phil Harrison. I was EiC of Kotaku at the time and rushing from one Xbox One preview appointment on Microsoft’s campus to another. I phoned the news in to reporter Jason Schreier, who wrote it up for the site.
Celtics Announce Jayson Tatum's Historic Playoff Milestone After 76ers Loss
Jayson Tatum has played big minutes for the Boston Celtics in their opening-round playoff series against the Philadelphia 76ers. Tatum is averaging a team-high 37.8 minutes per game this series, including 42 minutes in the 108-100 win on Friday and 41 minutes in Tuesday’s 113-97 loss. Tatum scored 24 points in the matchup and secured 16 rebounds.
Simple treatment tweak drastically reduces blood loss from severe cuts
A procedure that could be done in half an hour, and prepared ahead of time, could seriously reduce blood loss from severe wounds, such as during surgery
Tributes Pour In After Justin Simmons Announces Retirement At 32
Justin Simmons, one of the best defensive backs the NFL has seen over the past decade, is hanging up his cleats at the age of 32. Simmons started his NFL career with the Denver Broncos in 2016. The former Boston College star quickly blossomed into an All-Pro safety at the next level. After spending ...
How should Rangers approach Tynecastle showdown?
Following a damaging home defeat to Motherwell, Danny Rohl has plenty to ponder with Rangers' Scottish Premiership title hopes hanging by a thread. A trip to face league leaders Hearts is being billed as a must-win fixture for the Ibrox side, who sit four points off the summit with four games remaining. Having seemingly settled on a 4-2-2-2 shape, Sunday's loss to Jens Berthel Askou's side has thrown Rohl's preferred system into question.
Newcastle braced for intense transfer summer
As intense as last summer's transfer window was for Newcastle, there could be even more transfer activity in the coming months as such a rebuild is going to require smart trading, given the financial rules in place. A theory has been put forward externally that Newcastle would benefit from dropping out of European football, as it would enable the club to spend up to 85% of their football-related revenue and net profit/loss from player sales under the Premier League's new squad cost regulations, as opposed to 70% for those competing in Uefa's competitions.
Gabbiadini calls for perspective
Former Sunderland striker Marco Gabbiadini believes there is no point in criticising Regis le Bris' side after their 5-0 defeat by Nottingham Forest last Friday as they have been "consistent" and "relentless" in their first season back in the Premier League. The Black Cats struggled for much of the game as Forest ran riot in the first half and took an insurmountable 4-0 lead before Elliot Anderson added another in the second half to hand Sunderland their biggest loss this season.
Record European Heatwaves Shrink Glaciers And Diminish Snow Cover In 2025
Around 95% of Europe experienced above-average temperatures in 2025, with record heatwaves from the Mediterranean to the Arctic region. This caused rapid loss
Caesars Entertainment Posts Narrower Loss as Revenue Rises
The hotel and casino company’s sales in its Las Vegas business remained steady at $1 billion, while revenue increased across its regional and digital channels.
James Harden says Cavs 'extremely confident' after losses to Raptors
James Harden considers the Cavaliers' problems in Game 3 and 4 losses to the Toronto Raptors as "self-inflicted and things that we can control."
Your job can actually kill you: More than 840,000 people die annually from health conditions linked to work stress, ILO report says
A new ILO report says long hours, job insecurity, bullying, and other psychosocial risks at work are tied to a total 1.37% loss of the global GDP.
‘Jurassic Park’ Star Shares Health Update After Cancer Battle
He “was at a loss” when chemo stopped working.
“Jurassic Park” star Sam Neill reveals health update after cancer treatment stopped working: 'I was on the way out'
The Australian star, 78, was "at a loss" amid treatment.
Hickman girls soccer goes 1-2 in Southwest Missouri Shootout
The Hickman girls soccer team suffered two losses in penalty kicks during its 1-2 trip to Webb City, along with other Kewpies results from the past week.
Why do discussions about ‘brain health’ ignore mental illness?
“Failing to adopt a more inclusive concept of brain health represents a massive loss of human potential,” write Husseini K. Manji, Eric J. Nestler, and Patrick J. Kennedy.
Bulldog hoops lands former juco star Perry from BYU
(KSEE/KGPE) – The losses have been heavy in the transfer portal recently for the Fresno State men’s basketball team, but the roster rebuild got a big boost Monday, as the program’s head coach Vance Walberg announced the signing of a very intriguing prospect, K.J. Perry from BYU. Perry was a highly-touted junior college recruit, who […]
Dumas Teases Welterweight Move After Latest Loss
Sedriques Dumas continued to struggle at UFC Vegas 116. The Floridian “Reaper” started off his UFC career well enough, winning three of his first five bouts in addition to his Contender Series success. Unfortunately, it’s been off the rails ever since, as he’s winless in his last four fights. He was stopped in all three […]
NBA fines Lakers guards Marcus Smart, Luke Kennard for interaction with referees after Game 4 loss, Adou Thiero ejection
Australia's Star Entertainment narrows third-quarter losses
Australian embattled casino operator Star Entertainment narrowed its third-quarter loss on Tuesday, reflecting the impact of cost savings and higher operator fee revenue.
Australia’s Star Entertainment narrows third-quarter losses
Australia’s Star Entertainment narrows third-quarter losses
Australia's Star Entertainment Narrows Third-Quarter Losses
April 28 (Reuters) - Australian embattled casino operator Star Entertainment narrowed its third-quarter loss on Tuesday, reflecting the impact of cost savings and higher operator fee revenue. The company reported a loss before interest, taxes, depreciation and amortization for the ...
City touts long-term rewards of hosting NFL Draft even as some businesses took losses
Although local businesses had been hoping for better sales during the NFL Draft, officials remain optimistic that the success of the event will bring visitors...
Directive 8020's glossy, late-’90s sci-fi aesthetic gives it an edge
My hands-on shows how smart art direction can reshape familiar horror tropes.
LeBron James takes blame for turnovers, poor performance in Game 4 loss to Rockets: 'It started with me'
UT Health San Antonio researchers awarded grant to study how circadian rhythm disruptions may contribute to Alzheimer’s - UT Health San Antonio
Environmental stressors like jet lag, high-fat foods suspected as disease risk Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu Content provided by Claire Kowalick SAN ANTONIO, April 27, 2026 – Can jet lag cause more than just sleep loss? Do quick-grab, high-fat foods associated with late-night or rotating work shifts bring more than indigestion? Those circadian […]
Inside the endoscopic revolution in weight loss
Article explains how bariatric endoscopy — including endoscopic sleeve gastroplasty and transoral outlet reduction — combined with metabolic therapies and GLP-1 receptor agonists is expanding nonsurgical obesity treatment options and reframing obesity as a chronic, multifactorial disease.
Political appointments surging, career SES workforce shrinking under Trump 2.0
The federal government has reached its highest level of political appointments in decades, while also undergoing a significant loss of career senior leadership — a combination that one organization warns will lead to poor outcomes across agencies.
3 takeaways from Lakers’ Game 4 loss vs. Rockets
It took four games, but the Rockets have finally beaten the Lakers.
Denver business owners fear cultural loss as historic Asia Center redevelopment looms
Plans to redevelop the Asia Center on Federal Boulevard at Tennessee Avenue have raised concerns among business owners and community members who fear for the preservation of the area's cultural history.
Bennett, Lapid, and the bromance that could decide Israel's next election
On paper, Bennett and Lapid had no business being allied. However, the personal trust between them is the central campaign promise.
Vermont sees drop in health insurance enrollment after subsidy cuts
Learn about the impact of the federal budget bill HR.1 on Vermont's healthcare system, including loss of subsidies and changes to Medicaid eligibility.
Science & Medicine: Weight loss surgery without the scalpel
Obesity rates in South Texas exceed the national average, but many patients hesitate to pursue bariatric surgery due to the risks involved. UT Health San Antonio now offers endoscopic alternatives that achieve comparable weight loss results with no incisions, shorter recovery times, and lower risk.
Patients taking weight-loss drugs often make 5 critical mistakes, doctor warns
Experts say GLP-1 drugs offer benefits beyond weight loss, but common mistakes like skipped labs and poor nutrition can undermine results or cause harm.
Waterpik’s Cordless Advanced 2.0 Water Flosser is 32% Off
The device has the American Dental Association Seal of Acceptance for effectiveness.
Why Trump's winning streak at the Supreme Court came to an abrupt end
The Trump administration won a series of high-profile victories last year, but the president has made fewer emergency appeals and is facing losses on his signature policies.
Against all official odds: Jerusalem business owners struggle to survive as the state dithers
Tax-paying business owners should have access to the timely financial assistance they need to keep their show on the road.
Phillies lose 10th straight, first since 1999
The Phillies dropped their 10th straight game as a pivotal sixth inning and more offensive issues sealed another loss to Atlanta.
PENN Entertainment (PENN) Near Breakeven Q1 Loss Tests Bullish Profitability Narratives
PENN Entertainment (PENN) opened Q1 2026 with revenue of US$1.8b and a basic EPS loss of US$0.02, alongside net income excluding extraordinary items of a US$2.3m loss. The company’s quarterly revenue moved from US$1.7b in Q1 2025 to US$1.8b in Q1 2026, while EPS shifted from a profit of US$0.73 to a small loss in the latest quarter, creating a mixed picture of topline scale against continued pressure on profitability and margins. See our full analysis for PENN Entertainment. With the headline...
Man Loses 200 Pounds With Lifestyle Changes and This Daily Drink
Adam Bird lost half his body weight by making sustainable lifestyle changes, including walking to the gym and prioritizing nutrition.
Popular weight loss drug linked to key benefits for patients undergoing TAVR, PCI
Two separate studies explored the value of treating heart patients with tirzepatide.
Samsung may be bracing for first-ever annual loss in smartphone business
The AI-driven memory shortage is hitting Samsung's bottom line.
Samsung may be bracing for first-ever annual loss in smartphone business
The AI-driven memory shortage is hitting Samsung's bottom line.
Blowing Rock student turns grief into state science fair award
BLOWING ROCK — A Blowing Rock student wanted to find a way to include her dogs in her sixth-grade science project. What followed was months of research, the loss of
Penn Entertainment (PENN) Stock Price Jumps 17% After Posting Record Quarter as Interactive Losses Narrow 88 Percent
Penn Entertainment's online casino division delivered its strongest quarter on record in Q1 2026, with iCasino revenue growing 15 percent year-on-year and the
Looking back, looking forward on a spring semester of Texas sports
Baseball: Looking back: Loaded with a talented transfer portal class headlined by junior outfielder Aiden Robbins and junior catcher Carson Tinney, Texas baseball has jumped out to an impressive 30–8 record in head coach Jim Schlossnagle’s second year on the Forty Acres. Looking forward: The starting pitching trio of sophomore Dylan Volantis, senior Ruger Riojas...
Insurance loss puts child care center out of business
Lakeside Early Learning in Duluth will continue to offer child care through June 4 as staffing and ratios allow.
'A landmark moment for the field': FDA approves first-ever gene therapy for inherited deafness
A gene therapy made by Regeneron is the first treatment of its kind approved for genetic hearing loss.
Sports roundup: Southold tennis serves up a loss for Mattituck
Josh Uguna smashed an ace to clinch his third doubles match with partner Joe Moran, to give Southold an insurmountable 4-2 lead over host Mattituck in its Suffolk County boys tennis match on Thursday, April 16. The Settlers’ duo recorded a 6-2, 6-7, 9-7 win over Monte Lang and Matt Kuzman. Southold (5-2, 5-2) recorded...
Giant, 60-foot octopuses were apex predators 100 million years ago, fossil discovery shows
Rare fossil finds show colossal octopuses were among the top ocean predators during the Cretaceous Period, according to a new study.
Scientists just discovered a 60-foot long, kraken-like octopus
The discovery, using novel techniques to analyze fossilized jaws, details how colossal octopuses hunted the Late Cretaceous depths, competing with apex predators.
Devin Booker calls out NBA official James Williams by name after Suns' Game 2 loss: 'Terrible tonight'
Mapped: the elections that could deliver ‘unprecedented’ losses for Labour
All signs point to a record low performance for Labour in May in what will be a moment of high jeopardy for Keir Starmer
'Big loss' for F1 if Verstappen quits, say McLaren rivals
If four-time world champion Max Verstappen were to quit Formula One, as he has hinted on numerous occasions, it would be a "big loss" for the sport, his McLaren rivals Lando Norris and Oscar Piastri said on Wednesday."I think it would be a big loss for the sport as a whole.
Amazon launches weight loss drug program
Demand for weight loss drugs is ballooning across the U.S. — and Amazon wants in.
Ratings: Much-changed Atlético lose to Elche despite Nico brace
It marks Atleti’s fourth consecutive loss in LaLiga.
As Democrats Outraise Republican Candidates, the G.O.P. Has This $600 Million Edge
Even as the party faces a worrisome political environment and its candidates are outraised by Democratic ones, powerful Republican groups and super PACs have built a colossal advantage.
Trump political director on midterm outlook: ‘It’s way too soon to declare defeat’
President Trump’s political director James Blair expressed his confidence on Wednesday for GOP midterm election victories, despite falling economic approval ratings and a recent loss on a redistric…
2026 L&S Academic Staff Career Awards Announced
Five receive L&S Academic Staff Career Award honors in three categories: Early Career, Mid-Career, and the Judith Craig Distinguished Service Award.
Samsung is increasingly worried about first-ever mobile division loss in RAM crisis, report
As AI continues to eat up the market’s RAM output, smartphones are in crisis as costs continue to skyrocket. A...
Now what for Chelsea? Five losses in a row for manager Liam Rosenior leave few good short or long-term options
As Chelsea struggle to stay in the race for a Champions League spot, what's the path to winning and profitability for their owners?
Sports Daily: What will Chiefs do? NFL Draft starts tomorrow
In a season full of tough losses for the Royals, Monday night’s setback might’ve been the worst. Is there hope in KC after a season-worst 7-16 start?
Boeing’s Commercial Jet Business Improves, Reducing Quarterly Loss
The plane maker reported brisk first-quarter commercial sales, despite wiring flaws that delayed some deliveries.
‘The GOP should’ve done more’: Virginia Republicans point fingers after gerrymandering loss
They are frustrated the party didn’t spend extensively and are putting pressure on Florida to give them back an edge.
Spurs star Victor Wembanyama leaves Game 2 loss to Portland early, enters concussion protocol after smacking face on court
The Trail Blazers rallied from a 14-point hole in the fourth quarter to stun the Spurs on Tuesday night after Victor Wembanyama entered concussion protocol.
Health insurers raise questions about Medicare program that will offer GLP-1s to seniors for $50
Some health insurers are pushing back against a new program that will allow Medicare beneficiaries to pay $50 per month for GLP-1 medications for weight loss.
Former Southern Miss president and polymer science pioneer Shelby Thames dies at 89
The University of Southern Mississippi is mourning the loss of one of its former presidents.
Why Business Owners Delay Exit Planning
Most business owners know they should plan their exit—but identity, fear of loss, and complexity quietly make it far harder than it seems.
Business groups optimistic on Sherrill budget
The governor has proposed limiting businesses' ability to deduct losses as part of her $60.7 billion budget proposal.
Seattle Mariners Bullpen Falters in 6-4 Loss to Athletics
The Mariners failed to preserve an early lead and whiffed on several opportunities late against the A's.
Mira Costa boys volleyball gets revenge against rival Redondo Union
Mira Costa boys' volleyball defeats Redondo Union in four sets to avenge an earlier loss this season to the Sea Hawks and stake its claim to a No. 1 playoff seed.
Same problems, different night for Penguins in Game 2 loss to Flyers
For two days all the Penguins could talk about was turning the page on their Game 1 loss to the Flyers. Their problem was they still ended up taking notes...
Painted Tree closure locks out vendors, leaving Houston small businesses scrambling
Houston vendors said they’ve been locked out of Painted Tree stores after sudden closures, struggling to recover inventory and facing steep financial losses.
[TUY8S1.1] Cherry Blossom Event, Creator Collaboration & Updates
Cherry blossoms are falling across D.C., and something new has come with them. A Creator Collaboration with Otsuichi, Rezina, and Mobilmobil adds its own activities and rewards to the update.
Virginia Sen. Mark Warner's daughter dies after long health battle
Virginia Senator Mark Warner is mourning the loss of his daughter, Madison, who died following a decades-long health battle
Cubs hand Mets their 11th straight loss by rallying for a 2-1 win in 10 innings
It’s the longest losing streak for the Mets since 2004.
Boosting the berry business
Blueberry growers recover from the blues and strawberries have their saviors after a blistery—by Florida standards—winter. Add other growing challenges and Southwest Florida’s berry businesses need a boost. Still, it’s peak season for blueberries in the area and residents can enjoy the healthy treat as the crop losses mostly affect commercial buyers, local growers said.
Blockbuster GLP-1 Diabetes and Weight Loss Drugs Fails in Alzheimer’s Trial
Researchers are exploring whether GLP-1 medications used for diabetes and weight loss could treat Alzheimer’s and addiction.
Sports Buzz: Bears suffer Revivalry losses in 3 sports, softball walks off Utah
Baseball, men’s tennis and women’s tennis all lost to TCU this weekend, while softball bounced back and women’s basketball landed a new transfer.
This Hits Home: News that impacts Seattle-area families
This week: Gas Work Park safety order, library levy goes to voters at $480, early learning losses, child care gains, and RSV news
Detroit Pistons home playoff losing streak now at 18 years
The Detroit Pistons extended their NBA-record home playoff losing streak to 11 games with a Game 1 loss to the Orlando Magic on Sunday, April 19.
New study reveals how maze-like magnetic patterns form and evolve in materials
Maze magnetic domains in soft magnetic materials strongly influence energy loss in electric motors, particularly at high temperatures. However, existing models struggle to explain their complex, temperature-dependent behavior. To address this gap, researchers developed an entropy-extended Ginzburg-Landau model combined with data-driven analysis to study these structures. The approach reveals how entropy and energy interactions drive magnetization reversal and increasing domain complexity, providing new insights into magnetic energy-loss mechanisms.
Five takeaways from Virginia baseball’s series win over Clemson
Following yet another mid-major midweek loss, the Virginia Cavaliers won their fifth ACC series against Clemson over the weekend. The Wahoos improved to 12-9 in conference play and 28-13 overall in the process. UVA pieced together rallies in the second and sixth innings en route to a fiery 6-4 victory in the series opener. The […]
Mets extend losing streak to 11 in excruciating fashion with blown shutout by Devin Williams, loss to Cubs in extras
The Mets’ losing streak was on the ropes on Sunday. But a blown save spoiled a ninth-inning shutout, and the Cubs prevailed in extras to extend New York’s misery.
Warriors' Draymond Green praises Dillon Brooks' impact on Suns this season
Golden State Warriors star Draymond Green had praise for longtime nemesis Dillon Brooks after Friday's play-in tournament loss.
Indiana defensive coordinator Bryant Haines calls out Ty Simpson for remarks, tells Alabama fans to 'grow up'
Bryant Haines took offense to Ty Simpson's recent podcast remarks and responded with receipts -- and no interest in softening the message after his unit delivered one of the worst losses in Alabama history