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Collins not heading to Dallas GOP convention
While speaking to reporters in Brewer on Tuesday, Collins said many of the Republicans facing tough races will not be in attendance.
Scientists in Switzerland made a sponge from cheesemaking waste that captures gold from discarded electronics — after dissolving metal parts from 20 old computer motherboards, they recovered enough to melt into a 22-carat gold nugget
A Swiss lab transformed dairy waste into a gold-recovery tool, extracting precious metal from e-waste that most recyclers leave behind.
Seminoles Surrender Back Breaking Play in 4th Quarter
FSU suffered a blow in the fourth quarter when SMU wideout Yannick Smith caught a 79 yard touchdown. Even though FSU responded, it was the biggest explosive play of the game, and the one that sticks out the most when you consider SMU had three plays of 50 yards or more, and eight plays of +15 yards.
Peter Stanbury on the business case for sustainablity in drinks
As we count down to next month’s Sustainability in Drinks event in London (October 21), Dr Peter Stanbury, research director of the influential Sustainable Wine Roundtable , makes the case for why all drinks companies should be taking not just taking sustainability seriously but how increasingly it is being seen by banks and insurance houses as a vital part of running an effective and competent business and a prerequisite for their continued support.
California voters can fix a flaw in the state's recall system
Proposition 5 on the November ballot would prevent a governor's replacement from taking office by winning just marginal support. It's the first step toward a badly needed overhaul.
Devon Witherspoon responds to Christian Gonzalez trumping his historic deal
The wait has finally come to an end for Christian Gonzalez after he was rewarded with his record-breaking new deal by the New England Patriots. Whether the contract stand-off has had any effect on his preparations for Wednesday’s game in Seattle remains to be seen.
Belgium battle could be a blessing
It is a new chapter for Aston Villa and, against Club Brugge, they turned the page. A first win of the season, albeit more nervy than anticipated, lit the spark for Unai Emery's side. The visitors were in a commanding and deserved position at half-time, John McGinn's opener making him the club's all-time record European goalscorer with 12.
Student view: Building a business from a passion for baking
MSU senior Jade McLellan shares how campus programs, mentors and an internship helped her grow Baking By Jade and prepare for an entrepreneurial career.
Ex-Philadelphia Phillies Player Cut Loose By New MLB Team
As the Philadelphia Phillies are currently taking on the Houston Astros in a new series this week, a piece of notable roster news dropped on a recent Phillies player. Phillies fans shouldn’t have forgotten by outfielder Max Kepler yet, as Kepler played his entire 2025 season with Philadelphia. Well, on Tuesday, Kepler was released by […] The post Ex-Philadelphia Phillies Player Cut Loose By New MLB Team appeared first on HEAVY.
Entertainment District Around Akins Ford Arena Starts to Take Shape
Selling or leasing county-owned property around Akins Ford Arena has always been part of the plan for funding its construction, and the Athens-Clarke County Commission took another step toward that goal last week. The county is putting a parcel known as the Kelley Diversified tract on Willow Street up for sale. The old City of Athens bought the land and built a warehouse in 1970, and for a time it was used for vocational training. The unified government declared it surplus in 2007, but bids came in well below expectations, so it was never sold. However, since then the area between downtown and the North Oconee River has been built up, so the property could be more desirable to developers […]
Kaweah Health Special: Advancing Cardiac Care in the Valley
CBS47’s Kathryn Herr presented a Kaweah Health special titled “Advancing Cardiac Care in the Valley,” which featured local health experts discussing groundbreaking cardiac procedu…
Lions’ Aidan Hutchinson Makes Waves With Comment on Dan Campbell
Detroit Lions edge rusher Aidan Hutchinson said he supports head coach Dan Campbell taking a more serious approach with the team. The post Lions’ Aidan Hutchinson Makes Waves With Comment on Dan Campbell appeared first on HEAVY.
Republicans hold first-ever midterm convention in Dallas
Republicans are making political history this week with the first-ever midterm convention.
“Spider-Man: Brand New Day ”and “The Odyssey ”boost 2026 domestic box office to best summer on record
“Brand New Day” is the highest-earning summer release in over a decade, and this summer’s record-breaking gross more than doubles that of last summer’s.
Netanyahu will make a quick trip to speak at the UN after Mamdani urged his arrest, diplomat says
Israel’s Prime Minister Benjamin Netanyahu is making a whirlwind 24-hour trip to speak at the U.N.’s annual gathering of world leaders this month after New York’s mayor urged his arrest over the war in Gaza, That's according to Israel’s U.N. Ambassador Danny Danon on Tuesday | WWJ Newsradio 950
Netanyahu will make a quick trip to speak at the UN after Mamdani urged his arrest, diplomat says
Israel’s Prime Minister Benjamin Netanyahu is making a whirlwind 24-hour trip to speak at the U.N.’s annual gathering of world leaders this month after New York’s mayor urged his arrest over the war in Gaza, That's according to Israel’s U.N. Ambassador Danny Danon on Tuesday | K-DAWN
Man sentenced after breaking child's fingers while working for health facility
A man is avoiding jail time after breaking a child's fingers in 2025 and not reporting the injuries while working for KidsPeace, officials said.
Making Sense of Phoenix Suns' Biggest Storyline This Season
As roster shifts trade elite shooting for raw athleticism, Phoenix faces a high-stakes gamble on Miles Bridges to elevate their ceiling amidst looming threats of early-season regression.
What Will Life Science Orgs Do When The AI Bill Comes Through?
AI is transforming clinical development, but what happens when usage costs spike? Jon Newton explains how to govern it before the bill lands.
Mike Tomlin Reveals ‘Best’ Steelers Team he Coached
Mike Tomlin is making the media rounds as he begins his new career in broadcast. This comes after 19 seasons as head coach of the Pittsburgh Steelers. Tomlin won a Super Bowl early in his tenure and was known for never having a losing season in Pittsburgh. However, fans began to clamor for change in […] The post Mike Tomlin Reveals ‘Best’ Steelers Team he Coached appeared first on HEAVY.
Why Kayshon Boutte could be immediately fantasy football relevant
Boutte will be making plays alongside Nico Collins
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Three-time MVP Aaron Judge returns to Yankees
BRONX, N.Y. (WIVT/WBGH) – Sticking with the diamond, let’s move up to the major leagues where the Yankees are set to welcome back the captain tonight. Aaron Judge is making his return in the pinstripes tonight. No. 99 ironically had a 99-day absence after he suffered a broken rib. The three-time AL MVP missed 84 […]
Gemini app makes Daily Brief free in the US
After introducing at I/O 2026 in May, Google is making Daily Brief in the Gemini app available for free in the US.
Senate Set to Vote to Begin Debate on Protect College Sports Act
Background The Protect College Sports Act of 2026 (PCSA), introduced in the Senate on June 2, 2026, by Senators Ted Cruz (R-TX) and Maria Cantwell (D-WA) and joined by Senators Eric Schmitt (R-MO) and Chris Coons (D-DE), represents a comprehensive federal legislative effort to reshape the governance and economics of intercollegiate athletics, including redistributing the significant media revenues generated by college sports. Reported favorably 19-9 from the Senate Commerce Committee and placed on Senate Calendar No. 449 on June 24, 2026, the PCSA was substantially revised on August 7, 2026 (Senate Amendment 6768). The PCSA arrives against a backdrop of cascading judicial decisions that have systematically dismantled the National Collegiate Athletic Association’s (NCAA) authority to regulate the economics of college sports.
BREAKING: Key Rams Player Is OUT Against The 49ers
Well, so much for seeing Aaron Donald and Myles Garrett together in Week 1. Donald will not travel to Australia with the Rams and has been ruled out for Thursday night’s season opener against the San Francisco 49ers. That’s a major break for Brock Purdy and the 49ers. Donald recently came out of a two-year…
49ers catch massive break for Week 1 battle vs. Rams
The 49ers are taking on the Rams in Week 1 of the 2026 season, but their division rivals won't have one of their best players for the matchup.
Small Gym September: Meet Beyond Cheer Athletics
Beyond Cheer Athletics is presenting New York City strong! Learn more about the program that is already making a name for itself from 2020 to now!
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Russell Peters opens up about race, politics and why he still needs comedy
Russell Peters talks race, prejudice, politics, and why making people laugh still matters.
The Galaxy Z Fold 8 is outselling Samsung's record-breaking Fold 7 by a wide margin
Samsung finally explained the engineering behind the gap.
Microsoft September 2026 Patch Tuesday fixes 966 flaws, 2 zero-days
Today is Microsoft's September 2026 Patch Tuesday, with security updates released for a record-breaking 966 flaws, including two actively exploited zero-day vulnerabilities.
Why Don’t Diamondbacks Streak?
Inspiration. I very much enjoyed Jim McLennan’s The Arizona Diamondbacks Have Not Gone Streaking. I learned that the Diamondbacks have not won 7 consecutive games since 7 September 2017 (a very long time). And I tip my hat to JWinMesa for his comment to that article. A summary is that as measured by Total Streak […]
The U.S. bishops are speaking out forcefully on politics—and finally being heard
Prompted by the beginnings of both Leo XIV’s papacy and the second term of Donald J. Trump, the bishops are using their voice in a new way.
Ink Business Unlimited vs. Spark Cash Select: Which is best?
The Ink Business Unlimited and Spark Cash Select both earn 1.5% cash back with no annual fee. But the Ink Business Unlimited is better for most businesses.
Your Business Is Growing — So Why Aren't You Making More Money? Here's the Revenue Trap Many Founders Fall Into.
More clients, more employees and more revenue can look like success. But if growth isn’t creating more profit, a stronger company and a better life, you may simply be building a bigger job.
New law to force tech firms to prevent children from taking nude images
The government said it will legislate "as soon as they can" but may "reassess" its plans if firms make the desired changes sooner.
Amazon Is Taking Preorder Requests for Pokémon TCG 30th Celebration ETBs Well Below Market Price, Marking a Rare First for US Collectors
Amazon US is accepting invite requests for Pokémon TCG 30th Celebration ETBs at $89.99—roughly $90 below market resale value on TCGplayer.
Campbell’s investing to turn around Snacks business
National media campaigns to feature Goldfish and Pepperidge Farm.
The New York Times: A new editor for Politics
Ben Shpigel, who’s guided fast-breaking coverage on Live and Sports, will help elevate real-time political coverage at The New York Times.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Sunderland 'deserved more' at Brentford
Marco Gabbiadini says Sunderland deserved to win at Brentford after taking the game to their opponents on Saturday. The former Sunderland striker, speaking to Radio Newcastle, believes the Black Cats' attacking approach could have earned them all three points and suggested the result could prove significant when looking back at the end of the season. "If you finish the season in a similar position to what we finished last season and you look back over it, you might look back and think this is one that could have taken us another place up the table," said Gabbiadini.
Ask Pete Dougherty your questions about the Green Bay Packers
Pete Dougherty is taking questions as the Green Bay Packers head into the Week 1 season opener against the Minnesota Vikings in Minneapolis.
Cowboys projected to have 52% chance of making the playoffs
Are the Cowboys a playoff team in your opinion?
Alonso on injuries, Estevao reports and being 'self-demanding'
Chelsea boss Xabi Alonso has been speaking to the media before Wednesday's Carabao Cup third-round tie against Leeds United at Stamford Bridge (kick-off 20:00 BST). Caicedo could be back for Saturday's Premier League game against Hull City, though. Levi Colwill will be available for selection, but Jordan Henderson and Emmanuel Emegha will not feature.
DeWitt’s Crossroads Business Park gets ready for growth
DEWITT, Iowa – Community leaders and development partners recently celebrated the groundbreaking of five regional water detention ponds in an expansion of the Crossroads Business Park, marking a major milestone in preparing the site for future industrial growth. The project is the first phase of infrastructure improvements that will make approximately 125 acres of development […]
California’s political hopefuls remain silent on state’s job losses, unemployment
Dan Walters Commentary: The aspirants for those positions are making all sorts of promises to win voters’ approval. But few, if any, have mentioned a slow-motion menace affecting a fundamental
Penélope Cruz, Javier Bardem on Speaking Out on Politics at Venice
Penélope Cruz and Javier Bardem discussed their willingness to speak out about politics at a Venice Film Festival press conference for 'Bunker.'
The insurgent Democrat taking on David Valadao
The 31-year-old progressive is betting his working-class roots and economic message can energize voters in one of the country’s youngest congressional districts.
MDI Health to Honor Mount Desert Nursing Association with 2026 Impact Award
BAR HARBOR—MDI Health will honor Mount Desert Nursing Association (MDNA) as its 2026 Community Partner of the Year during the organization’s Annual Meeting and Community Celebration on Tuesday, September 15. MDNA will receive the 2026 Impact Award in recognition of its longstanding commitment to providing in-home nursing, physical and occupational therapy, and medical equipment to the Island region. By caring for people where they live, MDNA helps patients remain safely and independently at home, providing reassurance and support to their families. “Mount Desert Nursing Association exemplifies the power of community partnership,” said Chrissi Maguire, President and CEO of MDI Health. “Its nurses bring skilled, compassionate care directly into people’s homes, helping patients navigate illness, recovery, and some of life’s most difficult moments. We are deeply grateful for MDNA’s service and the important role it plays in the health of our community.” MDNA works closely with MDI Health providers and care teams to support continuity of care following hospitalization, surgery, illness, or changes in health. Its personalized services extend care beyond the hospital and help ensure patients receive the support they need close to home. “For 77 years, MDNA has been here for our community, helping our neighbors recover and remain safely at home. Our long-standing partnership with MDI Health is an important part of making that possible. Together, we help ensure a seamless transition from hospital to home and provide patients with the continued care they need. We are incredibly grateful for this recognition and especially proud of our talented and hardworking team,” said Amy McVety, Executive Director of Mount Desert Nursing Association. The Impact Award will be presented during MDI Health’s Community Celebration from 5 to 7 p.m. at the Bar Harbor Club. The event will also recognize outstanding employees, volunteers, and trustees; celebrate MDI Health’s achievements over the past year; and mark a transition in Board leadership as Madeleine Braun, PhD, MBA, prepares to succeed Martha Wagner, PhD, as chair. The celebration will feature music, refreshments, the MDI Health Auxiliary Raffle, and a cash bar. MDI Health’s Annual Business Meeting will take place from 3:30 to 4 p.m. via Zoom. These events are free and open to the public, but space is limited. To reserve your spot, contact Patrianna Anderson at 207-288-5082, ext. 1432, or visit mdihospital.org/communitycelebration. Subscribe Share Leave a comment
BOOK REVIEW: 'Charlie St. Cloud'
In the village of Marblehead, Mass., 28-year-old Charlie St. Cloud has spent his adult years taking care of the lawns and monuments of the cemetery where his younger brother, Sam,
Farke on James, squad rotation and Chelsea
Leeds United boss Daniel Farke has been speaking to the media before Wednesday's Carabao Cup third-round tie against Chelsea at Stamford Bridge (kick-off 20:00 BST). Farke said there's "a little question mark" over Daniel James as he "reported an issue with his back after the warm-up at Brighton". He added: "The scan results were good. Farke confirmed there will be some squad rotation against Chelsea to help "integrate new players".
On 988 Day, Vibrant Emotional Health Reminds Everyone: With 988 Reasons to Reach Out, Your Reason is Reason Enough
Today, September 8 (9/8), Vibrant Emotional Health (Vibrant), the nonprofit administrator of the 988 Suicide & Crisis Lifeline, joins the Substance Abuse and Mental Health Services Administration (SAMHSA) and communities across the country in recognizing 988 Day, a national day of awareness led by SAMHSA to highlight the 988 Suicide & Crisis Lifeline and the importance of making mental health support accessible to everyone.
McInnes vision becoming clear amid step in right direction
The past week or so has been faultless results-wise for Derek McInnes. It's a shame for Lawrence Shankland to facing a spell out injured after beginning to find form with three goals in two games. The transfer window overall was okay, but we can't be making bold statements on the back of three wins against teams Rangers should be beating.
The Daily Mauling: 9/8/26
Kansas Jayhawks News Matt Tait gives you his thoughts on how Kansas performed against Long Island, and how much it actually means moving forward Next up for the football team? The Border War. Or whatever we should be calling it now that’s it’s just a lame non-con game we shouldn’t be playing Speaking of the […]
Bijan Robinson projected to have record-breaking year for Falcons
Bijan Robinson could break Darren Sproles' all-purpose yards record in 2026
Clarksville Celebrates Groundbreaking of New $148.5 Million Health Campus - Clarksville Online - Clarksville News, Sports, Events and Information
Clarksville, TN - Hundreds gathered for a groundbreaking and blessing ceremony on the 96-acre site where Ascension Saint Thomas, a $148.5 million health
NFL Power Rankings: Week 1
The hardest part about doing NFL power rankings for Week 1 is that no one really has any freaking clue where these teams should be. We’re just projecting based on last season’s performance and the changes made over the offseason, but reality will be a completely new outcome. I decided to give the Super Bowl […]
We Might All Pay For Corpus Christi’s Water Crisis
The Sparkling City by the Sea is the nation’s largest energy exporter. Costs could rise for all of us as it confronts an existential threat of its own making. Decades of overconfidence and complacence got it here.
A Haredi political revolt is brewing – and it could shake up Israel's election
Veteran Haredi politicians are losing favor with top rabbis, shaking up party slates. Meanwhile, new parties are outflanking the establishment on its left and right. But will they really be any different?
Beat reporter makes very bold prediction for Panthers' 2026 season
The Athletic's bold prediction for the 2026 Panthers has the team's defense making a massive leap.
Making Aliyah? Your healthcare plan should begin before the flight
Medical records, medication continuity and a plan for children’s care can make the move to Israel safer and far less stressful.
Christian Gonzalez signs historic new deal with Patriots
Christian Gonzalez has signed a four-year, $135 million contract extension with the New England Patriots, making him the highest-paid cornerback in NFL history.
Stevie Nicks’ fans praying for her after heartbreaking announcement. Here’s the latest
The singer has yet to comment on the tragic news.
How influencers are taking center stage in Burbank
LOS ANGELES — The exterior of the two-story, beige-colored building looks like any other drab office space near the Hollywood Burbank Airport. But on a recent weekday afternoon, the inside
Exclusive: Daryl Mitchell backs ETPL to produce cricket's next superstars
Daryl Mitchell is one of the big names taking part in the inaugural European T20 Premier League this season with the Dublin Guardians, and the New Zealand international is backing the new franchise league to make a huge mark.
The House Democrat who's making AI regulation her No. 1 priority
Rep. Lori Trahan passed on a bid for leadership to focus on artificial intelligence policy last week
Pac-12 football power rankings: Boise State clearly No. 1, but then what?
After nearly taking down Oregon, Boise State is the clear frontrunner in the Pac-12 and favorite for the College Football Playoff.
Patriots' Christian Gonzalez sends immediate reaction to massive contract extension
It is finally over. The New England Patriots and Christian Gonzalez waited until less than two days before opening kickoff to get a deal done, but they have agreed to a record-breaking, four-year, $135 million contract extension. Fans can take a deep breath , and so can the highest-paid cornerback in NFL history. “Thank you Lord!” he posted on […] The post Patriots' Christian Gonzalez sends immediate reaction to massive contract extension appeared first on ClutchPoints.
9/11’s Dust and Ash Coated Their Childhood. Is It Still Making Them Ill?
Much of the research on exposure to the World Trade Center residue has focused on emergency workers, but people there when they were young say their health is at risk, too.
Why the Buffalo Bills are Sporting News' pick to win Super Bowl 61
Sporting News' latest annual Super Bowl prediction says the Bills will win their first ring post-NFL merger after breaking through to end their 33-season AFC championship drought.
Instant analysis of Patriots' blockbuster Christian Gonzalez extension
Taking a closer look at the Patriots making Christian Gonzalez the highest-paid cornerback in NFL history.
Christian Gonzalez signs record-breaking contract extension with Patriots
The Patriots and the star cornerback have reportedly reached an agreement.
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New York's source for breaking news and live streaming video online. Covering New York City, New Jersey, Long Island and all of the greater New York Area.
Nikon ZR Firmware Version 2.00 & future Open Gate Recording
Nikon has announced that firmware version 2.00 for the Nikon ZR will be released in October. This will include focus peaking display during recording in
Duke professor Dan Ariely seeks political office in Israel with Pirate Party
After having an article retracted due to allegations of research fraud, Dan Ariely is taking his efforts elsewhere: Israel. He is running on the Pirate Party slate in the Israeli legislative elections Oct. 27.
'BreakingTheCycle': Chandler students hosting PMOS Women's Health Walk
High school students in Chandler are hosting the state's first PMOS Women's Health Walk at Tumbleweed Park to raise awareness and fund research at Boston Children's Hospital.
Naomi Osaka exits U.S. Open, but not before displaying one more 'swaggy' fashion ensemble
Naomi Osaka may not have gone out of the U.S. Open with much of a bang. The two-time U.S. Open champion lost a lopsided fourth-round match on Monday to Elena Rybakina. Osaka, already known for her walk-on fashion reveals at tournaments, has been upping her game at the year's final major with a series of dramatic ensembles — all with a basketball theme, as her sponsor, Nike, honors the New York Knicks' championship win.
The science behind making the perfect banana
Huawei tests ‘logic folding’ chip in handset with higher AI stakes ahead
New smartphone processor is a crucial test of the firm’s attempt to route around lack of access to the best chipmaking technology.
Acton attack suspect not registered with political party, voted in 2016 GOP primary
Amy Acton was eating a sandwich, taking pictures and talking with people at the Canfield Fair when Tra Eley says she stopped at his food truck Sunday.For roughl
Folly Beach road construction cuts traffic as some businesses see record highs, others low
As summer winds down on Folly Beach, some businesses are closing out the season with record-breaking profits while others are reporting low numbers, with major
Ascension medication error raises new concerns over potential Williamson Health sale
Williamson County commissioners are preparing for their first vote as county leaders consider taking the next step toward a potential sale of Williamson Health
Detroit Lions Name 7 Captains for 2026 Season
The Detroit Lions have selected seven captains for the 2026 season, with Jack Campbell, Alim McNeill and Jack Fox earning the honor for the first time. The selections reveal a leadership transition taking place around Detroit's established core.
A galaxy-shaking clash comes to Warhammer TV this week
Necron C’tan Shards and Tyranid monsters collide on Battle Report.
Is investing in mental health an overlooked opportunity?
EXPERT INSIGHT: If you’re an impact investor, what’s your first reaction to mental health? Do you immediately think of founders’ wellbeing, of highly scalable, AI-enabled therapy apps, or do you believe it’s a personal topic that isn’t investable at all?
Health experts track early rise in respiratory illnesses ahead of fall and winter
Labor Day may mark the unofficial end of summer, but respiratory viruses are already making the rounds as doctors look ahead to the fall and winter virus season.
Georgia Southern football prepares for Clemson in week two
STATESBORO, GA (WJBF)- Week two of the college football season features one local matchup in Georgia Southern and Clemson. Both teams coming into the game with something to prove. The Eagles are coming off a 31-0 victory over Charleston Southern, making it their first shutout win at home since 2023. They’ll now face a bigger […]
Cowboys Announce Injury Update That Could Impact Eagles Game
The Dallas Cowboys have suffered a major injury ahead of Week 1 of the 2026 NFL season. The Philadelphia Eagles are certainly taking notice of the situation. According to ESPN’s NFL insider Adam Schefter, the All-Pro left guard Tyler Smith suffered a thumb injury this offseason. As a result, the star lineman will undergo surgery. […] The post Cowboys Announce Injury Update That Could Impact Eagles Game appeared first on HEAVY.
Port of Grandview works to attract new businesses with active marketing and land development
The BriefThe Port of Grandview is actively marketing the community to attract new business development, with efforts including attendance at trade shows and conventions like Food Northwest in Portland.The Port reports strong demand for business property, with several prospective clients currently seeking space to build in Grandview.The Port recently acquired 45 acres for its new Woodworth Road Business Park, with planning underway to support the community's continued growth.GRANDVIEW — The Port of Grandview is capitalizing on strong interest in the community by actively marketing Grandview to businesses seeking locations for expansion and growth. The Port's efforts are paying off, with increased development activity and growing demand for available business property.Grandview's appeal stems from multiple factors. The community's available land and central location between the Tri-Cities and Yakima make it an attractive option for businesses looking to establish or expand operations. The Port has recognized these advantages and is taking a proactive approach to market the community directly to potential clients.Port Executive Director Randy Tucker says the Port has been actively attending trade shows and conventions to promote Grandview as a business destination. These events, including Food Northwest in Portland, provide opportunities to connect with companies actively seeking new locations."Say, hey, locate your business here and bring your customers here. And it's worked out pretty good for us," Tucker said.The Port's marketing strategy is generating results. The Port reports strong demand for business property, with several prospective clients currently looking for space to build in Grandview. This interest reflects the effectiveness of the Port's outreach efforts and the community's appeal to businesses in various industries.To support this growth, the Port recently acquired 45 acres for its new Woodworth Road Business Park. Planning is underway to determine how the property can best support Grandview's continued development and attract additional businesses to the area.The combination of available land, strategic location, and active marketing positions Grandview as an increasingly attractive option for businesses seeking to relocate or expand. As the Port continues its efforts to promote the community, Grandview appears poised for continued economic growth and development. News Three Queens Fire approaching 10,000 acres, now 11% contained Robert Desaulniers, Josh Culbreth News Two injured after rear-end crash leads to rollover near Grandview Robert Desaulniers News Grandview High School temporarily enters secure and teach for possible altercation between students Robert Desaulniers News Port of Grandview pursues economic growth with new business park development William Albert, Apple Valley News Now News Driver dies in fiery crash in Columbia Park Friday Erin Wencl COPYRIGHT 2026 BY APPLE VALLEY NEWS NOW. ALL RIGHTS RESERVED. THIS MATERIAL MAY NOT BE PUBLISHED, BROADCAST, REWRITTEN OR REDISTRIBUTED.
Le Creuset x Star Trek Collection: Prices, availability, release date
Vulcan oven mitts, spaceship baking dishes, and an out-of-this-world communicator grater—you'll need warp speed to Klingon to this limited edition kitchen kit, ideal for perfecting the broth of Khan.
Ahoy, Knesset: Israel’s Pirate Party sets sail with Dan Ariely on its slate
The veteran fringe party filed a 25-person list for the October election, with the behavioral economist and best-selling author taking the No. 3 spot.
Rybakina sweeps past Osaka to close in on number one ranking
Elena Rybakina sweeps aside two-time champion Naomi Osaka to reach the US Open quarter-finals and close in on becoming world number one.
Mental Health Monday: Self Care
Heidi Carman with Valley Health, joined Holly Baratta to tell us about self-care and how it helps in understanding our limits and taking care of our mental health.
Michigan politicians spent Monday shaking hands with voters, a day after an armed man charged at an Ohio candidate
The Ohio State Highway Patrol says an armed assailant charged toward the Democratic candidate for Ohio governor, Amy Acton, during a campaign stop at the Canfield Fair, injuring several people before he was stopped by troopers.
UCF Focused on Containing Pittsburgh QB Mason Heintschel
After a record-breaking seven-touchdown performance, Pitt's dual-threat star faces a violent UCF defense determined to cage the pocket and erase their road woes in this non-conference showdown.
Astros' Yordan Alvarez receives brutal Triple Crown prediction from ESPN
This prediction would be heartbreaking for the Astros and Alvarez.
Giants’ Cox Making Strong Case for Long-Term Role
Amidst a dismal season for the San Francisco Giants, Jonah Cox’s elite speed and defensive versatility offer a spark of hope for the team’s future.
How Gabriel Jesus turned rejection to acceptance from Barcelona
Gabriel Jesus completed his move to Barcelona in the final days of the last transfer window, but it was a move that had been in the making for a long time.The Brazilian was one of the players struggli...