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Results for " und " 50,739 found 🔀 AI-powered Shuffle

After testing all major mobile browsers, this one finally earned my default spot

Looking beyond Chrome paid off with the best browser experience

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Oct 25 • 6:00 PM EDT • Technology • androidpolice.com
Trump escalates rhetoric against El-Sayed as he tries to undermine Democrat in Michigan Senate race

The Republican president has been attacking El-Sayed's faith throughout the campaign and claiming his past statements and background show a sympathy for extremists.

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Oct 25 • 5:50 PM EDT • Politics • pbs.org
Serbia’s strongman leader Vucic concedes defeat to student-led movement in seismic political shift

The long-serving strongman leader of Serbia, Aleksandar Vucic, conceded defeat on Sunday in an election that pitted him and his right-wing party against a diverse student-led opposition movement that spent two years protesting his government.

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Oct 25 • 5:50 PM EDT • Politics • cnn.com
Lawmakers propose $11M fix to restore school sports and activities funding

by Katie Klingsporn, WyoFile Wyoming’s new school funding model added more than $250 million in state education funding, including for widely supported

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Oct 25 • 5:45 PM EDT • Sports • capcity.news
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Orlando Magic's Sean Sweeney Message to Paolo Banchero After Injury

As a grueling road trip looms, assistant coach Sean Sweeney challenges his squad to maintain their identity and intensity while navigating Paolo Banchero’s absence against elite competition.

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Oct 25 • 5:37 PM EDT • Sports • sports.yahoo.com
Missile makers see multi-year deals as politics-proof

Executives at the military’s biggest suppliers say the Pentagon’s new multi-year munitions deals are the surest way to navigate an uncertain funding climate.

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Oct 25 • 5:34 PM EDT • Politics • punchbowl.news
Aleksandar Vucic: Serbia's veteran ruler felled by student-led movement

The dominant force in Serbian politics for over 14 years, Aleksandar Vucic, who conceded defeat in a snap parliamentary poll on Sunday, rose from the wreckage of strongman Slobodan Milosevic's cabinet...

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Oct 25 • 5:20 PM EDT • Politics • yahoo.com
Oregon State gains ground in AP poll after bye week

The Beavers gained votes in the AP poll, but dropped in the coaches poll.

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Oct 25 • 5:19 PM EDT • Sports • sports.yahoo.com
Scott Walker’s The Drift will get under your skin

Walker’s 2006 album is unsettling, bizarre, and the perfect way to kill a party.

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Oct 25 • 5:08 PM EDT • Entertainment • theverge.com
Volkswagen Bet On Xpeng To Save Its China Business, But Buyers Aren't Showing Up

Volkswagen once dominated China’s automotive market, but the rise of domestic electric vehicle manufacturers has turned its fortunes upside down. Hoping to regain lost ground, the German automaker partnered with Chinese EV specialist Xpeng in ... Read more

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Oct 25 • 5:00 PM EDT • Business • finance.yahoo.com
New York Giants' Cam Skattebo Just Saved His Job

New York Giants running back Cam Skattebo saved his job against the Houston Texans.

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Oct 25 • 4:37 PM EDT • Sports • sports.yahoo.com
Brad Pitt's Underrated Sci-Fi Astronaut Movie Deserved Better At The Box Office

You likely missed this critically acclaimed Brad Pitt sci-fi thriller when it was in theaters, but it's a film that warrants a watch.

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Oct 25 • 4:17 PM EDT • Entertainment • yahoo.com
A YouTuber dissected an iPhone Duo and thinks he found the cause of crackgate

A weak spot in the hinge may be failing and cracking iPhone Duo screens.

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Oct 25 • 4:16 PM EDT • Technology • theverge.com
Bears Offensive Blueprint on Full Display in Win Over Patriots
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Oct 25 • 4:14 PM EDT • Sports • sports.yahoo.com
How Pratt Proved Brewers Right in the World Series

Shrugging off an early error, rookie Cooper Pratt delivered a clutch game-winning hit, vindicating the Milwaukee Brewers long-term investment.

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Oct 25 • 4:00 PM EDT • Sports • sports.yahoo.com
Scientists Discovered an Amazing Practical Use For The World's Leftover Coffee Grounds

We shouldn't throw it out.

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Oct 25 • 4:00 PM EDT • Science • sciencealert.com
Scientists Discovered an Amazing Practical Use For The World's Leftover Coffee Grounds

We shouldn't throw it out.

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Oct 25 • 4:00 PM EDT • Science • yahoo.com
Photo: Jude Bellingham’s head-turning new boots for Barcelona showdown

Real Madrid star Jude Bellingham has on Sunday evening provided a look at the head-turning footwear that he is set to make use of in El Clásico.The latest edition of Spanish football’s most bitter ...

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Oct 25 • 3:45 PM EDT • Sports • sports.yahoo.com
Primark's Business Doesn't Make Sense

In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot

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Oct 25 • 3:31 PM EDT • Business • finance.yahoo.com
The Politics of Heaven ~ The Imaginative Conservative

The key to understanding Thomas More’s generous dedication to the real but limited good he could do on earth is, as Frank Mitjans makes clear, that More’s constant contemplation of God was the source of his boundless care for the souls surrounding him. Thomas More’s Vocation, by Frank Mitjans

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Oct 25 • 3:20 PM EDT • Politics • theimaginativeconservative.org
Bayern beat Freiburg to reclaim top spot after Kompany illness

Bayern Munich reclaimed top spot in the Bundesliga with a 3-1 win at Freiburg on Sunday, days after coach Vincent Kompany was hospitalised when he collapsed at training.With coach Kompany still in hospital after collapsing on Friday, Englishman Danks was in the dugout.

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Oct 25 • 3:11 PM EDT • Sports • sports.yahoo.com
NZ’s hidden chronic health burden is even bigger than we thought

New research reveals a major gap in how chronic illness is measured, with implications for planning and funding healthcare in New Zealand.

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Oct 25 • 3:10 PM EDT • Health • theconversation.com
Retailers in Paris React to Protests [PHOTOS]

Retailers Assess Cost of Lost Business After Second Round of Protests

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Oct 25 • 3:08 PM EDT • Business • wwd.com
Sky Sports share rumours of unhappy Leeds United star live on air vs Sunderland

Daniel Farke looking unimpressed as Leeds United take on Sunderland at Stadium of Light on 25 October

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Oct 25 • 3:05 PM EDT • Sports • sports.yahoo.com
Dodgers’ De Paula Faces Key Defensive Test

Josue De Paula impressed the Los Angeles Dodgers with his bat during his major-league debut. Can he do the same with his defense?

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Oct 25 • 3:04 PM EDT • Sports • sports.yahoo.com
Supercurrent enables the reading of quantum information without destroying it

One of the fundamental challenges of quantum computing is obtaining information from a quantum bit, or qubit. Unlike a conventional bit, which can be read repeatedly without altering its content, direct ...

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Oct 25 • 3:00 PM EDT • Technology • phys.org
Asher Grunis steps down from leading Submarine Affair commission due to health concerns

Supreme Court President Isaac Amit appointed retired Supreme Court justice Zvi Zylbertal to replace Grunis and lead the commission on Sunday.

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Oct 25 • 2:58 PM EDT • Health • jpost.com
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After arts festival, San Francisco's Mid-Market businesses look for signs of a turnaround
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Oct 25 • 2:54 PM EDT • Business • cbsnews.com
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Nets' Second-Year G Dëmin Bounces Back Against Cavaliers

The Brooklyn Nets got a much-better performance from second-year BYU product Egor Dëmin against the Cleveland Cavaliers. With Mikel Brown Jr. on a minutes restriction, Dëmin needs to play a big role.

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Oct 25 • 2:49 PM EDT • Sports • sports.yahoo.com
Three Premier League talking points

Michael Carrick was pushed to the brink of the sack by Manchester United's latest debacle on Sunday.AFP Sport looks at three talking points from the weekend's action: Walls closing in on Carrick Michael Carrick's future as Manchester United boss was already hanging by a thread before Bournemouth inflicted what is likely to be a brutal last act for the former England midfielder at Old Trafford.

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Oct 25 • 2:36 PM EDT • Sports • sports.yahoo.com
Defender turns striker and scores in Bayern win

Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...

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Oct 25 • 2:27 PM EDT • Sports • sports.yahoo.com
Nigeria widens hunt for possible Ebola cases

Nigeria has widened a hunt for potential Ebola cases, with an additional nine contacts traced, health authorities said Sunday.The initial 44 contacts were health care workers, while the additional nin...

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Oct 25 • 2:26 PM EDT • Health • yahoo.com
MAPPED: The states Trump and top Democrats are targeting before Election Day

With Election Day less than two weeks away, Trump rallied in Florida, Georgia and Michigan as both parties deploy top surrogates to battlegrounds.

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Oct 25 • 2:15 PM EDT • Politics • foxnews.com
Windows 11 is apparently so bad that XBOX would rather cancel hardware than be forced to use the OS

A reported clash between Microsoft's XBOX and Windows teams suggests Windows 11's desktop may no longer be the foundation for Project Helix.

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Oct 25 • 2:14 PM EDT • Technology • windowscentral.com
Olympiacos May Attempt to Sign Genoa Midfield Maestro This Winter

Olympiacos are poised to reignite their pursuit of Morten Frendrup, testing Genoa's resolve after a rejected summer bid for the consistent Danish engine room specialist.

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Oct 25 • 2:01 PM EDT • Sports • sports.yahoo.com
Inside 26-year-old’s club for million-dollar Chattanooga business owners

At 2nd American Restaurant on Thursday night, around 85 entrepreneurs who have scaled their businesses to at least $1 million in annual revenue sat to a family-style meal of beef cheek roast, airline chicken and the restaurant's signature bowl of mashed potatoes.

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Oct 25 • 2:01 PM EDT • Business • timesfreepress.com
Navigating D1 pressure: how student-athletes balance their mental health

Mental health affects everyone, including athletes who have a really good way of hiding it. Research shows that mental health issues affect roughly 39-44% of Division I athletes. Behind game day, good game performance, and navigating life in college, D1 athletes are constantly trying to balance high expectations with their own well-being. It’s not...

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Oct 25 • 1:59 PM EDT • Health • nmsuroundup.com
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine

Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria contracted Ebola.

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Oct 25 • 1:45 PM EDT • Health • seattletimes.com
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine

Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria cont...

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Oct 25 • 1:44 PM EDT • Health • abcnews.com
Knicks Have Clear Advantage Over Magic With Lopsided Injury Report

The New York Knicks look for their first win of the season.

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Oct 25 • 1:36 PM EDT • Sports • sports.yahoo.com
COMMENTARY: Three reasons why Tennessee football imploded against South Carolina

Penalties, brain blips and a hangover conspire to doom Volunteers.

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Oct 25 • 1:33 PM EDT • Sports • sports.yahoo.com
Projections for Cleveland Guardians’ Arbitration Eligible Players

The Cleveland Guardians have several key players arbitration-eligible this offseason.

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Oct 25 • 1:30 PM EDT • Sports • sports.yahoo.com
Steelers Now Postgame: Steelers 16, Saints 10

Pittsburgh Steelers Postgame: Join Alan Saunders and Jobe Morrison after the Steelers’ Week 7 win over the Saints on YouTube, […]

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Oct 25 • 1:18 PM EDT • Sports • sports.yahoo.com
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‘You Can See Everything’ surges with $19.5M at box office; ‘Clayface’ takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

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Oct 25 • 1:17 PM EDT • Entertainment • seattletimes.com
Sunday Open Thread

There is no Jays news and I’ve got nothing to talk about, so lets have an open thread. We had the second great World Series game in a row last night. I like watching baseball (or any sport) when I have no rooting interest. After a season of caring about every Jays game, I like […]

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Oct 25 • 1:17 PM EDT • Sports • sports.yahoo.com
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'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KCBS All News 106.9FM and 740AM

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KNSS Radio

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

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Oct 25 • 1:16 PM EDT • Entertainment • clickorlando.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KMBZ

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

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Oct 25 • 1:16 PM EDT • Entertainment • news4jax.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...

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Oct 25 • 1:16 PM EDT • Entertainment • stamfordadvocate.com
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1

NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...

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Oct 25 • 1:16 PM EDT • Entertainment • usnews.com
What Will It Take for Rockies to Make World Series?

It's been since 2007 for the Colorado Rockies to be a part of the World Series. Is there any hope for a return to the Fall Classic?

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Oct 25 • 1:14 PM EDT • Sports • sports.yahoo.com
Clatsop County health inspections for September

Clatsop County health inspectors recently completed a round of restaurant inspections that yielded overwhelmingly positive results for most local eateries. But one Seaside establishment received a temporary closure after receiving […]

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Oct 25 • 1:10 PM EDT • Health • dailyastorian.com
Argentina Folk Sounds, Controversy: Milo J, Cazzu, Broke Carey

Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside and sharing their history with the world.

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Oct 25 • 1:09 PM EDT • Politics • rollingstone.com
How Argentina’s Folk Sounds Are Shaping a Generation’s Politics and National Pride

Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside, staving off pop homogenization and sharing their history with the world

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Oct 25 • 1:09 PM EDT • Politics • yahoo.com
Carrick ‘not expecting’ Man United crisis talks despite Bournemouth defeat

Michael Carrick said he is ‘not expecting’ imminent talks about his future despite Manchester United’s latest defeat.Carrick’s position as head coach looks under threat after Manchester United...

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Oct 25 • 1:08 PM EDT • Sports • sports.yahoo.com
China Star Entertainment (SEHK:326) Stock Looks Richly Priced As Its 8.6x Run Continues

China Star Entertainment has logged very strong multi year share gains, so the key issue now is whether the current price can be supported by the value of assets on its balance sheet. For anyone looking at the stock today, the immediate question is how that share price lines up against its book value. Over the past 3 years the stock has returned about 8.6x. This puts a lot of weight on whether the underlying equity in the business justifies this kind of move when you compare it with the...

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Oct 25 • 1:06 PM EDT • Entertainment • finance.yahoo.com
Steelers beat Saints to win first NFL game in Paris

The Pittsburgh Steelers defeated the New Orleans Saints 16-10 on Sunday to win the first-ever NFL regular season game in Paris. The low-scoring game had only one touchdown for each team.

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Oct 25 • 1:03 PM EDT • Sports • sports.yahoo.com
3 Cubs Who Will Decline Their Options
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Oct 25 • 1:01 PM EDT • Sports • sports.yahoo.com
'Sound of Music' star Julie Andrews spotted in rare Hamptons outing weeks after turning 91

Julie Andrews, 91, was photographed in the Hamptons wearing a purple raincoat and pink sunglasses in a rare public outing in the coastal city.

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Oct 25 • 1:00 PM EDT • Entertainment • yahoo.com
The Making Of: Addams Family Values, Ocean Software's Attempt to Mix Hollywood & the Legend of Zelda

"Management didn't really understand development or the creative process"

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Oct 25 • 1:00 PM EDT • Technology • timeextension.com
NFL Week 7 Sunday afternoon open thread

Join us at Buffalo Rumblings as we chat all things NFL Week 7 LIVE with like-minded folks in Bills Mafia

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Oct 25 • 12:59 PM EDT • Sports • sports.yahoo.com
Oregon fires offensive coordinator Drew Mehringer after team scored just 10 points in loss to Illinois

Saturday's loss marked the third straight game in which Oregon scored under 20 points.

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Oct 25 • 12:57 PM EDT • Sports • sports.yahoo.com
Broncos Place Linebacker, Running Back On Injured Reserve

The Denver Broncos have a fluid injury situation, with Tyler Badie and Jonah Elliss being placed on injured reserve.

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Oct 25 • 12:57 PM EDT • Sports • sports.yahoo.com
Jay Glazer Shares Jalen Hurts Health Update, NFL And NFLPA Joint Investigation

On "FOX NFL Sunday," Jay Glazer shared the latest on Jalen Hurts' health and said that the NFL and NFLPA are doing a joint investigation.

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Oct 25 • 12:52 PM EDT • Health • foxsports.com
Blanche says Trump isn’t trying to meddle with Alaska election results by suing over Senate race

WASHINGTON (AP) — Attorney General Todd Blanche on Sunday defended the Trump administration's lawsuit to block certification of Alaska's Senate results if Repub

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Oct 25 • 12:51 PM EDT • Politics • wtop.com
Saints Lose Defensive Battle in Paris Against Steelers

A very winnable game that a better team would have won.

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Oct 25 • 12:36 PM EDT • Sports • sports.yahoo.com
Sunday Puzzle: BRB

NPR's Ayesha Rascoe plays the puzzle along with Weekend Edition Puzzlemaster Will Shortz and WUOT listener Jordan Bogdan of Oak Ridge, Tennessee.

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Oct 25 • 12:30 PM EDT • Entertainment • kgou.org
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Lakers 1st-Round Draft Pick Floated as Trade Piece

The Los Angeles Lakers are off to a fast start. Could it be time to weigh trading away some young pieces to boost the rotation? The post Lakers 1st-Round Draft Pick Floated as Trade Piece appeared first on HEAVY.

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Oct 25 • 12:29 PM EDT • Sports • sports.yahoo.com
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Lakers’ Injury Report Rules Out Two Players for Jazz Game

Is Walker Kessler available in his return to Utah?

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Oct 25 • 12:21 PM EDT • Sports • sports.yahoo.com
One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie

Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.

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Oct 25 • 12:17 PM EDT • Entertainment • yahoo.com
Kings' Veterans Praise Rookie Acuff After 33-Point Showing

The Sacramento Kings are yet to get a win, but Darius Acuff Jr. looks like the high-octane guard that the franchise so desperately needs. Coming off a 33-point outburst, how will Acuff play against the Memphis Grizzlies?

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Oct 25 • 12:13 PM EDT • Sports • sports.yahoo.com
Buccaneers vs. Panthers Week 7 inactives: Baker Mayfield returns

The Tampa Bay Buccaneers are set to take on the Carolina Panthers Sunday afternoon in a crucial NFC South matchup at Bank of America Stadium in Charlotte. Tampa Bay received some encouraging news ahead of kickoff as quarterback Baker Mayfield is officially active and will start after missing the previous three games with a dislocated […]

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Oct 25 • 12:05 PM EDT • Sports • sports.yahoo.com
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Data center boom sparks massive power line fights hundreds of miles away

In Cat Kemmerling’s dream, she and her husband Rob are sitting in their pickup truck on a cliff on their West Virginia farm, overlooking the Shenandoah River. The truck is falling backwards over the edge, into the abyss below.

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Oct 25 • 12:00 PM EDT • Politics • cnn.com
Political cartoons for October 25

Sunday's political cartoons include increasing costs, the White House briefing room, and more

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Oct 25 • 12:00 PM EDT • Politics • theweek.com
Connections: Law firms hire attorneys for NWA offices

Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...

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Oct 25 • 11:50 AM EDT • Politics • talkbusiness.net
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Connections: Law firms hire attorneys for NWA offices

Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...

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Oct 25 • 11:50 AM EDT • Business • talkbusiness.net
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Scientists Discover a Plant Compound That Could Help Stop Rheumatoid Arthritis Inflammation

Scientists have identified a plant compound that reduced joint swelling and inflammation in rats with experimental arthritis. The discovery offers a potential new direction for rheumatoid arthritis tr...

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Oct 25 • 11:49 AM EDT • Science • yahoo.com
AI coding agents hijacked using AGENTS.md file in Downloads folder

Researchers found a malicious AGENTS markdown instruction file in a customer's Downloads folder that tricked an AI coding agent into installing a rogue npm package.

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Oct 25 • 11:49 AM EDT • Technology • bleepingcomputer.com
Obama and Trump wage one last battle for even more urgent stakes

Two decades ago, Barack Obama stormed battleground states rebuking a Republican president over a deeply unpopular war and an economy that was crushing working Americans.

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Oct 25 • 11:45 AM EDT • Politics • cnn.com
Game Time Thread: Juventus vs. Lecce

MATCH INFO When: Sunday, Oct. 25, 2026. Where: Stadio Via del Mare, Lecce, Italy. Official kickoff time: 6 p.m. local time in Italy and across Europe, 8 p.m. in the United Kingdom, 1 p.m. Eastern time, 12 p.m. Central time, 10 a.m. Pacific time. (Please note that the fall time change in Italy goes into effect on Sunday, […]

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Oct 25 • 11:45 AM EDT • Sports • sports.yahoo.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Texas Tech Leads 'Bad' Week 8 for Big 12 Unbeatens

The Red Raiders’ playoff dreams hit a wall in Cincinnati as sloppy play and missed opportunities ended their unbeaten run. The Big 12 race is now more open than ever after surprising finishes elsewhere.

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Oct 25 • 11:28 AM EDT • Sports • sports.yahoo.com
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit

As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...

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Oct 25 • 11:08 AM EDT • Politics • yahoo.com
Seattle Mariners Rumors: Zach Neto Gaining Traction as Possible Target

The M's certainly have a need for what Neto can provide.

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Oct 25 • 11:00 AM EDT • Sports • sports.yahoo.com
Wrexham’s Summer Striker Decision Faces Fresh Scrutiny After Blackburn Defeat

Wrexham’s decision to back their current centre-forwards has become a renewed talking point after Saturday’s 2–0 defeat at Blackburn Rovers exposed the gap between attacking activity and a meaningful goal threat.

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Oct 25 • 11:00 AM EDT • Sports • sports.yahoo.com
Scientists Found One of The 'Chunkiest' Squid-Like Creatures Ever Known

A "thick and peculiar" cephalopod.

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Oct 25 • 11:00 AM EDT • Science • sciencealert.com
Evaluating DJ Herz After Bouncing Back from Injury with Nationals

After making his first MLB appearance in nearly two years, what should the Washington Nationals expect from DJ Herz in his third season with the organization?

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Oct 25 • 10:56 AM EDT • Sports • sports.yahoo.com
Grading Iowa Football's Loss To Minnesota

This may have been Iowa's worst quarterback performance since the dreadful 2023 season.

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Oct 25 • 10:30 AM EDT • Sports • sports.yahoo.com
Mavericks 'Very, Very Confident' in Rookie PG Behind Kyrie Irving

Spanish sensation Sergio de Larrea shined with 21 points against San Antonio, proving he can anchor the rotation while Dallas carefully manages Kyrie Irving’s heavy workload.

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Oct 25 • 10:29 AM EDT • Sports • sports.yahoo.com
NFL Trade Deadline Could Dramatically Change The AFC South Landscape

With top stars from the Titans, Colts, and Jaguars hitting the trade block, Houston’s rivals could strip their rosters of veteran talent to fuel a mid-season rebuild.

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Oct 25 • 10:22 AM EDT • Sports • sports.yahoo.com
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Preview

The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...

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Oct 25 • 10:15 AM EDT • Sports • sports.yahoo.com
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean

Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...

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Oct 25 • 10:08 AM EDT • Health • finance.yahoo.com
Silicon Valley software engineer pay ranked against other US cities

Bay Area software engineers retain a 53% pay premium after adjusting for local prices, Levels.fyi found. Taxes aren't included.

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Oct 25 • 10:00 AM EDT • Business • businessinsider.com
Manchester United vs Bournemouth: Live updates from Old Trafford

Under-fire Manchester United manager Michael Carrick is under enormous pressure heading into today’s Premier League clash with Bournemouth on the back of a seven-game run without a win.The boss has ...

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Oct 25 • 10:00 AM EDT • Sports • sports.yahoo.com
Trump touts U.S. oil business making ‘hundreds of billions’

President Trump tells rallygoers in Georgia that the United States’ oil and gas business is making “hundreds of billions of dollars because of what’s happened in the Middle East,” and predicts that prices at the pump will “come way down.”

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Oct 25 • 9:42 AM EDT • Business • nbcnews.com
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Clemson HC Dabo Swinney Waving White Flag on Season

Following a humbling loss to Virginia Tech, Dabo Swinney is recalibrating expectations as the Tigers abandon playoff dreams and fight to salvage a disappointing, sub-par season.

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Oct 25 • 9:36 AM EDT • Sports • sports.yahoo.com
Liverpool host Brighton; Man Utd take on Bournemouth in PL

2026-10-25T13:33:41ZA rundown of today's games...2pm kick-offs:Liverpool vs BrightonManchester United vs BournemouthHull City vs BrentfordCrystal Palace vs Newcastle4:30pm kick-off:Sunderland vs Leeds...

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Oct 25 • 9:33 AM EDT • Sports • sports.yahoo.com
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'All INdiana Politics': Engling, Ballard clash over restoring credibility to Indiana Secretary of State Office

INDIANAPOLIS — On Sunday’s edition of “All INdiana Politics,” Government Reporter Garrett Bergquist sat down with two candidates who are running for secretary of state, Republican Max Engling and independent Greg Ballard. Both candidates outlined contrasting approaches to restore credibility to an office plagued by controversy under outgoing Secretary Diego Morales. They both presented different […]

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Oct 25 • 9:30 AM EDT • Politics • wishtv.com